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TANASE Sumio  棚瀬 純男

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… Alternative Names

棚瀬 純男  タナセ スミオ

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Researcher Number 20112401
Affiliation (based on the past Project Information) *help 2010: 熊本大学, 大学院・生命科学研究部, 教授
2007: 熊本大学, 医学部, 教授
2003 – 2005: 熊本大学, 医学部, 教授
2003: 熊本大学, 大学院・医学薬学研究部, 助教授
2002: 熊本大学, 医学部, 助教授 … More
1992 – 2000: KUMAMOTO UNIV., SCHOOL OF MEDICINE, ASSISTANT PROFESSOR, 医学部, 助教授
1988 – 1991: Kumamoto University Medical School, 医学部, 講師
1987: 熊本大学, 医学部, 助手 Less
Review Section/Research Field
Principal Investigator
Functional biochemistry / General medical chemistry / Structural biochemistry / 代謝生物化学
Except Principal Investigator
General medical chemistry / 応用薬理学・医療系薬学 / Experimental pathology / 医薬分子機能学 / Biological pharmacy / 物質生物化学 / Laboratory medicine
Keywords
Principal Investigator
Aminotransferase / アミノ基転移酵素 / NMR / Protein engineering / 補酵素 / タンパク質工学 / Catalytic activity / Pyridoxal / Aspartic acid / アスパラギン酸 … More / PCR / 変異酵素 / Induced fit / Amino acid substitution / Enzyme structure / 遺伝子工学 / サブユニット構造 / 酵素構造 / 触媒機能 / アミノ酸残基置換 / ピリドキサール / Aspartate carrier / Mitochondria membrane / オキソグルタル酸-リンゴ酸キャリヤー蛋白 / グルタミン酸-アスパラギン酸キャリヤー蛋白 / トランスポート / オキソグルタル酸ーリンゴ酸キャリヤー蛋白 / グルタミン酸ーアスパラギン酸キャリヤー蛋白 / 再構成 / ミトコンドリア膜 / Vitamin B6 / Coenzyme / Mutant enzyme / Substrate specificity / Alanine / アラニン酸 / ビタミンB6 / 基質特異性 / アラニン / Amino acid substiution / 安定同位体 / Induced Fit / シッフ塩基 / ヒスチジン残基 / 核磁気共鳴 / アミノ基転移 / 部位特異的突然変異 / Genetic engineering / サブユニット間相互作用 / ピリドキサ-ルりん酸 / アスパラギン酸アミノ基転移酵素 … More
Except Principal Investigator
遺伝子工学 / Induced fit / Amino acid substitution / Pyridoxal / 酵素構造 / アスパラギン酸 / 触媒機能 / アミノ基転移酵素 / アルブミン / ERK / Akt / Blood preparation / Functional evaluation / Artificial blood / Molecular design / Site-directed mutagenesis / Albumin preparation / 人工血液 / 血液製剤 / 遺伝子組換え技術 / アルブミン製剤 / fractalkine / PARC / ELC / SLC / LARC / Chemokine / YAC / MCP-3 / LD78 / ケモカイン / サイトカイン / Enzyme structure / Aminotransferase / Catalytic activity / Genetic engineering / ビタミンB6 / アミノ酸残基置換 / ピリドキサール / 変異体 / Stable Isotope / Nuclear Magnetic Resonance (NMR) / Aspartate Aminotransferase (AspAT) / ^<13>C / アスパラギン酸アミノ酸基転移酵素 / 安定同位体 / アスパラギン酸アミノ基転移酵素 / NMR / 核磁気共鳴 / complement C5a receptor / Apoptosis / mouse ES cells / Ribosomal protein S19 / JAK-STAT / 補体C5aレセプター / 補体C5aリセプター / アポトーシス / マウス胚性幹細胞 / S19リボソーム蛋白 / structural property / functional property / pharmacokinetics / long half-life / antioxidant activity / albumin preparation / recombinant / 機能特性 / 構造特性 / 体内動態 / 血中滞留性 / 抗酸化能 / 機能性アルブミン製剤 / 遺伝子組換え体 / Clinical application / 臨床応用 / 機能性評価 / 分子設計 / EST / chromosome 17 / DNA duplication / 遺伝子重複 / ヒト染色体17番 / 遺伝子ファミリー / BAC / fractalking / 染色体17番 / DNA重複 / Database / Silencer / Transcriptional factors / Cytokine / データベース / サイレンサー / 転写調節因子 / Aspartate / Catalytic function / Nuclear magnetic resonace / 核磁気共鳴(NMR) / Aspartic acid / アミノ酸転移酵素 / アミノ酸置換 / X-ray crystallography / Structure and function relationship / Substrate specificity / Aminotransferse / ピリドキサ-ル / X線結晶解析 / 機能構造相関 / 基質特異性 / アカルボース / 血液濾紙 / 新生児マススクリーニング / 酸性マルターゼ / II型糖原病 / 小胞体関連分解 / 化学シャペロン / 遺伝子多型 / 新生児スクリーニング / 酸性α-グルコシダーゼ / ポンペ病 / リソソーム病 / 臓器特異性 / 薬物結合部位 / エスコートプロテイン / ノックダウンレセプター Less
  • Research Projects

    (17 results)
  • Research Products

    (2 results)
  • Co-Researchers

    (25 People)
  •  Establishment of newborn screening and molecular basis of chemical chaperone therapy for glycogen storage disease II

    • Principal Investigator
      OKUMIYA Toshika
    • Project Period (FY)
      2007 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Laboratory medicine
    • Research Institution
      Kumamoto University
  •  Regulation of apoptosis by chemotactic human ribosomal protein S19 mutant protein.

    • Principal Investigator
      NISHIURA Hiroshi
    • Project Period (FY)
      2003 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Experimental pathology
    • Research Institution
      Kumamoto University
  •  血清アルブミンの新展開:ノックダウンレセプター及びエスコートプロテインとしての可能性

    • Principal Investigator
      OTAGIRI Masaki
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      応用薬理学・医療系薬学
    • Research Institution
      Kumamoto University
  •  The development of next-generation albumin preparation by mutagenesi s studies

    • Principal Investigator
      OTAGIRI Masaki
    • Project Period (FY)
      2002 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      医薬分子機能学
    • Research Institution
      Kumamoto University
  •  Design and Evaluation of Albumin Mutants for Clinical Application

    • Principal Investigator
      OTAGIRI Masaki
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (B).
    • Research Field
      Biological pharmacy
    • Research Institution
      KUMAMOTO UNIVERSITY
  •  Design and Functional Evaluation of Albumin Mutants for Improving Medicinal Efficacy

    • Principal Investigator
      OTAGIRI Masaki
    • Project Period (FY)
      1998 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (B).
    • Research Field
      応用薬理学・医療系薬学
    • Research Institution
      KUMAMOTO UNIVERSITY
  •  Analysis of substrate specificity of Alanine aminotransferase.Principal Investigator

    • Principal Investigator
      TANASE Sumio
    • Project Period (FY)
      1998 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Structural biochemistry
    • Research Institution
      KUMAMOTO UNIVERSITY
  •  Generation Mechanism of Human Chemokine Gene Family

    • Principal Investigator
      NOMIYAMA Hisayuki
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General medical chemistry
    • Research Institution
      KUMAMOTO UNIVERSITY
  •  Regulation of catalytic activity by the domain-domain interface interaction.Principal Investigator

    • Principal Investigator
      TANASE Sumio
    • Project Period (FY)
      1996 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Functional biochemistry
    • Research Institution
      KUMAMOTO UNIVERSITY
  •  Negative transcriptional regulatory mechanisms of cytokine LD78 which regulates hematopoiesis

    • Principal Investigator
      NOMIYAMA Hisayuki
    • Project Period (FY)
      1994 – 1995
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      General medical chemistry
    • Research Institution
      KUMAMOTO UNIVERSITY
  •  Protein structure for support Shiff's base reactivity of transamination reaction.Principal Investigator

    • Principal Investigator
      TANASE Sumio
    • Project Period (FY)
      1994 – 1995
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Functional biochemistry
    • Research Institution
      KUMAMOTO UNIVERSITY
  •  Changes of Active Site Structure with the Binding of Substrate in Aspartate Aminotransferase

    • Principal Investigator
      HIGAKI Tsuyosi
    • Project Period (FY)
      1992 – 1993
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      物質生物化学
    • Research Institution
      Kumamoto University
  •  Subunit Interaction and Function Relationship of Aspartate Aminotransferase.Principal Investigator

    • Principal Investigator
      TANASE Sumio
    • Project Period (FY)
      1991 – 1992
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      代謝生物化学
    • Research Institution
      KUMAMOTO UNIVERSITY
  •  Structure and Function of Aspartate Aminotransferase

    • Principal Investigator
      MORINO Yoshimasa
    • Project Period (FY)
      1990 – 1992
    • Research Category
      Grant-in-Aid for international Scientific Research
    • Research Institution
      KUMAMOTO UNIVERSITY
  •  Function and Structure Relationship of Mammalian Aspartate Aminotransferase.

    • Principal Investigator
      MORINO Yoshimasa
    • Project Period (FY)
      1990 – 1991
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      General medical chemistry
    • Research Institution
      Kumamoto University
  •  NMR STUDY OF ASPARTATE AMINOTRANSFERASE

    • Principal Investigator
      HIGAKI Tsuyoshi
    • Project Period (FY)
      1988 – 1989
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      General medical chemistry
    • Research Institution
      KUMAMOTO UNIVERSITY
  •  Identification and Function of Mitochondrial Aspartate- and Malate-Carrier ProteinsPrincipal Investigator

    • Principal Investigator
      TANASE Sumio
    • Project Period (FY)
      1987 – 1988
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      General medical chemistry
    • Research Institution
      Kumamoto University

All 2005 2004

All Journal Article

  • [Journal Article] S19 ribosomal protein dimer augments metal-induced apoptosis in a mouse fibroblastic cell line by ligation of the C5a receptor.2005

    • Author(s)
      Nishiura H, Tanase S, Shibuya Y, Futa N, Sakamoto T, Higginbottom A, Monk P, Zwirner J, Yamamoto T.
    • Journal Title

      J Cell Biochem. 94

      Pages: 540-543

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590350
  • [Journal Article] Functional analysis of recombinant human serum albumin domains for pharmaceutical applications.2004

    • Author(s)
      Matsushita S, Isima Y, Chuang VTG, Watanabe H, Tanase S, Maruyama T, Otagiri M.
    • Journal Title

      Pharmaceutical Research 21

      Pages: 1924-1932

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370759
  • 1.  HIGAKI Tsuyosi (70128304)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 0 results
  • 2.  OTAGIRI Masaki (80120145)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 1 results
  • 3.  SAKURABA Hitoshi (60114493)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 4.  KAI Hirofumi (30194658)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 5.  MORINO Yoshimasa (30028352)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 6.  NOMIYAMA Hisayuki (00156225)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 7.  MIURA Retsu (70093466)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 8.  KIRSCH J.F.
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 9.  OKUMIYA Toshika (50284435)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  HIROTSU Ken (10047269)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  YANO Takato (40239827)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  HAYASHI Hideyuki (00183913)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  KURAMITSU Seiki (60153368)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  KAGAMIYAMA Hiroyuki (80028555)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  IMAI Teruko (70176478)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  NISHIURA Hiroshi (90284760)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 17.  SHIBUYA Yoko (70094018)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 18.  OGAWA Minetarou (70194454)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  ARAKI Kimi (90211705)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  樋口 泰一 (40046868)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  ARNONE A.
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 22.  METZLER D.E.
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 23.  KUWATA Shigeki
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 24.  NOZAKI Syuei
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 25.  REUSER Arnold JJ
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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