TANASE Sumio 棚瀬純男

… Alternative Names

Researcher Number	20112401
Affiliation (based on the past Project Information) *help	2010: 熊本大学, 大学院・生命科学研究部, 教授 2007: 熊本大学, 医学部, 教授 2003 – 2005: 熊本大学, 医学部, 教授 2003: 熊本大学, 大学院・医学薬学研究部, 助教授 2002: 熊本大学, 医学部, 助教授 … More
Review Section/Research Field	Principal Investigator Functional biochemistry / 代謝生物化学 / Structural biochemistry / General medical chemistry Except Principal Investigator General medical chemistry / 応用薬理学・医療系薬学 / Laboratory medicine / 物質生物化学 / Biological pharmacy / 医薬分子機能学 / Experimental pathology
Keywords	Principal Investigator アミノ基転移酵素 / Aminotransferase / アスパラギン酸 / Aspartic acid / Pyridoxal / Catalytic activity / タンパク質工学 / 補酵素 / Protein engineering / NMR … More Except Principal Investigator 遺伝子工学 / アルブミン / アミノ基転移酵素 / 触媒機能 / アスパラギン酸 / 酵素構造 / Pyridoxal / Amino acid substitution / Induced fit / 変異体 / ピリドキサール / アミノ酸残基置換 / ビタミンB6 / Genetic engineering / Catalytic activity / Aminotransferase / Enzyme structure / サイトカイン / ケモカイン / LD78 / MCP-3 / YAC / Chemokine / LARC / SLC / ELC / PARC / fractalkine / アルブミン製剤 / 遺伝子組換え技術 / 血液製剤 / 人工血液 / Albumin preparation / Site-directed mutagenesis / Molecular design / Artificial blood / Functional evaluation / Blood preparation / Akt / ERK / ノックダウンレセプター / エスコートプロテイン / 薬物結合部位 / 臓器特異性 / リソソーム病 / ポンペ病 / 酸性α-グルコシダーゼ / 新生児スクリーニング / 遺伝子多型 / 化学シャペロン / 小胞体関連分解 / II型糖原病 / 酸性マルターゼ / 新生児マススクリーニング / 血液濾紙 / アカルボース / 基質特異性 / 機能構造相関 / X線結晶解析 / ピリドキサ-ル / Aminotransferse / Substrate specificity / Structure and function relationship / X-ray crystallography / アミノ酸置換 / アミノ酸転移酵素 / Aspartic acid / 核磁気共鳴(NMR) / Nuclear magnetic resonace / Catalytic function / Aspartate / 転写調節因子 / サイレンサー / データベース / Cytokine / Transcriptional factors / Silencer / Database / DNA重複 / 染色体17番 / fractalking / BAC / 遺伝子ファミリー / ヒト染色体17番 / 遺伝子重複 / DNA duplication / chromosome 17 / EST / 分子設計 / 機能性評価 / 臨床応用 / Clinical application / 遺伝子組換え体 / 機能性アルブミン製剤 / 抗酸化能 / 血中滞留性 / 体内動態 / 構造特性 / 機能特性 / recombinant / albumin preparation / antioxidant activity / long half-life / pharmacokinetics / functional property / structural property / S19リボソーム蛋白 / マウス胚性幹細胞 / アポトーシス / 補体C5aリセプター / 補体C5aレセプター / JAK-STAT / Ribosomal protein S19 / mouse ES cells / Apoptosis / complement C5a receptor / 核磁気共鳴 / NMR / アスパラギン酸アミノ基転移酵素 / 安定同位体 / アスパラギン酸アミノ酸基転移酵素 / ^<13>C / Aspartate Aminotransferase (AspAT) / Nuclear Magnetic Resonance (NMR) / Stable Isotope Less

Establishment of newborn screening and molecular basis of chemical chaperone therapy for glycogen storage disease II
- Principal Investigator
  
  OKUMIYA Toshika
- Project Period (FY)
  2007 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Kumamoto University
Regulation of apoptosis by chemotactic human ribosomal protein S19 mutant protein.
- Principal Investigator
  
  NISHIURA Hiroshi
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Kumamoto University
血清アルブミンの新展開:ノックダウンレセプター及びエスコートプロテインとしての可能性
- Principal Investigator
  
  OTAGIRI Masaki
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Kumamoto University
The development of next-generation albumin preparation by mutagenesi s studies
- Principal Investigator
  
  OTAGIRI Masaki
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  医薬分子機能学
- Research Institution
  Kumamoto University
Design and Evaluation of Albumin Mutants for Clinical Application
- Principal Investigator
  
  OTAGIRI Masaki
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Biological pharmacy
- Research Institution
  KUMAMOTO UNIVERSITY
Design and Functional Evaluation of Albumin Mutants for Improving Medicinal Efficacy
- Principal Investigator
  
  OTAGIRI Masaki
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  KUMAMOTO UNIVERSITY
Analysis of substrate specificity of Alanine aminotransferase.Principal Investigator
- Principal Investigator
  
  TANASE Sumio
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Structural biochemistry
- Research Institution
  KUMAMOTO UNIVERSITY
Generation Mechanism of Human Chemokine Gene Family
- Principal Investigator
  
  NOMIYAMA Hisayuki
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  KUMAMOTO UNIVERSITY
Regulation of catalytic activity by the domain-domain interface interaction.Principal Investigator
- Principal Investigator
  
  TANASE Sumio
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional biochemistry
- Research Institution
  KUMAMOTO UNIVERSITY
Negative transcriptional regulatory mechanisms of cytokine LD78 which regulates hematopoiesis
- Principal Investigator
  
  NOMIYAMA Hisayuki
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  KUMAMOTO UNIVERSITY
Protein structure for support Shiff's base reactivity of transamination reaction.Principal Investigator
- Principal Investigator
  
  TANASE Sumio
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Functional biochemistry
- Research Institution
  KUMAMOTO UNIVERSITY
Changes of Active Site Structure with the Binding of Substrate in Aspartate Aminotransferase
- Principal Investigator
  
  HIGAKI Tsuyosi
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  物質生物化学
- Research Institution
  Kumamoto University
Subunit Interaction and Function Relationship of Aspartate Aminotransferase.Principal Investigator
- Principal Investigator
  
  TANASE Sumio
- Project Period (FY)
  1991 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  代謝生物化学
- Research Institution
  KUMAMOTO UNIVERSITY
Structure and Function of Aspartate Aminotransferase
- Principal Investigator
  
  MORINO Yoshimasa
- Project Period (FY)
  1990 – 1992
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  KUMAMOTO UNIVERSITY
Function and Structure Relationship of Mammalian Aspartate Aminotransferase.
- Principal Investigator
  
  MORINO Yoshimasa
- Project Period (FY)
  1990 – 1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Kumamoto University
NMR STUDY OF ASPARTATE AMINOTRANSFERASE
- Principal Investigator
  
  HIGAKI Tsuyoshi
- Project Period (FY)
  1988 – 1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  KUMAMOTO UNIVERSITY
Identification and Function of Mitochondrial Aspartate- and Malate-Carrier ProteinsPrincipal Investigator
- Principal Investigator
  
  TANASE Sumio
- Project Period (FY)
  1987 – 1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Kumamoto University

All 2005 2004

All Journal Article

[Journal Article] S19 ribosomal protein dimer augments metal-induced apoptosis in a mouse fibroblastic cell line by ligation of the C5a receptor.2005
- Author(s)
  Nishiura H, Tanase S, Shibuya Y, Futa N, Sakamoto T, Higginbottom A, Monk P, Zwirner J, Yamamoto T.
- Journal Title
  
  J Cell Biochem. 94
  
  Pages: 540-543
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590350
[Journal Article] Functional analysis of recombinant human serum albumin domains for pharmaceutical applications.2004
- Author(s)
  Matsushita S, Isima Y, Chuang VTG, Watanabe H, Tanase S, Maruyama T, Otagiri M.
- Journal Title
  
  Pharmaceutical Research 21
  
  Pages: 1924-1932
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370759

1. HIGAKI Tsuyosi (70128304)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
2. OTAGIRI Masaki (80120145)

# of Collaborated Projects: 4 results

# of Collaborated Products: 1 results
3. SAKURABA Hitoshi (60114493)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. KAI Hirofumi (30194658)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. MORINO Yoshimasa (30028352)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. NOMIYAMA Hisayuki (00156225)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. MIURA Retsu (70093466)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. KIRSCH J.F.

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. OKUMIYA Toshika (50284435)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. HIROTSU Ken (10047269)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. YANO Takato (40239827)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. HAYASHI Hideyuki (00183913)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. KURAMITSU Seiki (60153368)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. KAGAMIYAMA Hiroyuki (80028555)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. IMAI Teruko (70176478)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. NISHIURA Hiroshi (90284760)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
17. SHIBUYA Yoko (70094018)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
18. OGAWA Minetarou (70194454)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. ARAKI Kimi (90211705)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 樋口泰一 (40046868)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. ARNONE A.

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. METZLER D.E.

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. KUWATA Shigeki

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. NOZAKI Syuei

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. REUSER Arnold JJ

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

TANASE Sumio 棚瀬 純男

棚瀬 純男 タナセ スミオ

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Analysis of substrate specificity of Alanine aminotransferase.Principal Investigator

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Regulation of catalytic activity by the domain-domain interface interaction.Principal Investigator

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Protein structure for support Shiff's base reactivity of transamination reaction.Principal Investigator

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Subunit Interaction and Function Relationship of Aspartate Aminotransferase.Principal Investigator

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TANASE Sumio 棚瀬純男

棚瀬純男タナセスミオ