HIRAFUJI Masahiko 平藤雅彦

… Alternative Names

HAMAUE Naoya 平藤雅彦

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Researcher Number	20142987
Other IDs
External Links
Affiliation (Current)	2022: 医療創生大学, 健康医療科学部, 教授
Affiliation (based on the past Project Information) *help	2007 – 2014: 北海道医療大学, 薬学部, 教授 2002 – 2003: 北海道医療大学, 薬学部, 助教授 1995 – 2000: 北海道医療大学, 薬学部, 助教授 1993: Health Sciences University of Hokkaido, FACULTY OF PHARMACEUTICAL SCIENCES, 薬学部, 助教授 1986 – 1992: 東北大学, 歯学部, 助手 1990 – 1991: 東北大学, 歯学部・歯科薬理学講座, 助手 1987: 東北大学, 歯学部・歯科薬理学講座, 助手
Review Section/Research Field	Principal Investigator Functional basic dentistry / Biological pharmacy / Biological pharmacy Except Principal Investigator Applied health science / Functional basic dentistry / 応用薬理学・医療系薬学 / 矯正・小児・社会系歯学 / 小児・社会系歯学
Keywords	Principal Investigator 一酸化窒素 / ラット / 歯髄 / ドコサヘキサエン酸 / 血管平滑筋細胞 / 血管内皮細胞 / docosahexaenoic acid / vascular smooth muscle cells / 歯髄炎 / セロトニン … More / 血小板活性化因子 / 組織障害 / Dental Pulp / Platelet-activating Factor / Endotoxin / 細胞内カルシウム / nitric oxide / エイコサペンタエン酸 / 誘導型NO合成酵素 / シクロオキシゲナーゼ / 一酸化窒素合成酵素 / cyclooxygenase / 血少板活性化因子 / 血管透過性 / プロスタグランジン / コルヒチン / セロトニン(5-HT) / 一酸化窒素(NO) / NO 合成酵素 / 消化管障害 / 抗がん剤 / エンテロクロマフィン細胞 / サブスタンスP / 異味症 / メトトレキサート / 制がん剤誘起性嘔吐 / トリプトファン水酸化酵素 / アラキドン酸代謝 / エンドトキシン / 微小循環障害 / 細胞間相互作用 / Arachidonate Metabolism / Tissue Injury / Microcirculation Disturbance / Cell-cell Interaction / 内毒素 / 循環障害 / 虚血 / 過酸化脂質 / アデニンヌクレオチド / Dental pulp / Microcirculatory disturbance / Ischemia / Lipid peroxides / Adenine mucleotides / カルシウムチャネル / アンギオテンシンII / 高血圧症 / intracellular calcium / calcium channels / 5-hydroxytryptamine / angiotensin II / プロスタグランジンI_2 / シクロオキシゲナーゼ-2 / 遺伝子発現 / 高血圧 / eicosapentaenoic acid / iNOS / prostaglandin I2 / インターロイキン / MAPキナーゼ / 細胞内情報伝達系 / inducible nitric oxide synthase / interleukin-1 / MAP kinase / signal transduction / 歯髄組織 / 血小板活性因子 / アラキドン酸代謝物 / PAF受容体 / PAF / プラキドン酸代謝物 / 炎症PAF受容体 / 細胞内Ca / PAF拮抗体 / PAFの生物検定法 / Pulp Inflammation / PAF Vascular Endothelial Cells / PAF Receptors / PAF Antagonists … More Except Principal Investigator 骨格筋細胞 / 骨吸収 / MCT4 / マーカー / ラット / ビスフォスフォネート / 骨代謝 / 歯の移動 / 骨形成 / 骨芽細胞 / Tooth Movement / Bone Resorption / Bone Formation / PAF / 圧力負荷 / 機械的ストレス / メタボリックシンドローム / 血清 / 糖尿病モデルマウス / 生活習慣病 / バイオマーカー / 抗体 / ミオカイン / 培養骨格筋細胞 / 増殖因子 / 骨格筋 / 擬似的運動負荷 / エネルギー代謝 / サーカディアンリズム / エルカトニン / 薬物感受性 / 時間薬理学 / サ-カディアンリズム / 骨 / circadian rhythm / bone resorption / mineralization / bisphosphonates / elcatonin / chronopharmacology / rat / 矯正学 / Bisphosphonate / Orthodontics / Osteoblast / 嘔吐 / 5-HT / 5-HT受容体 / エンテロクロマフィン細胞 / セロトニン / 脱顆粒 / 制がん剤 / 迷走神経 / Drug-induced emesis / Serotonin / 5-HT3-receptor / Enterochromaffin cell / Ferret / 一酸化窒素 / 歯根膜 / メカニカルストレス / Nitric Oxicide / Periodontal Tissue / Mechanical Stress / 起炎症性物質 / 血小板凝集 / 血管収縮 / 歯髓炎 / アドレナリン / 気道抵抗 / 抗アレルギー薬 / 血小板活性因子 / 肺抵抗 / 抗ヒスタミン薬 / 微小循環 / 歯髄の炎症 / 細胞内Ca / 氣道抵抗 / ビタミンB_1関連物質 / オータコイド / 毛細血管透過性 / 歯髄炎 / 神経性炎症 / 筋弛緩薬 / inflammatory mediators / platelet aggregation / vascular contraction / inflammation of the pulp / adrenaline / pulmonary respiration resistance / 血小板活性化因子 (PAF) / MC3T3-E1 / 血小板活性因子(PAF) / 血小板活性化因子 / Platelet Activating Factor (PAF) Less

An investigation of endocrine factors from cultured skeletal muscle cells and the effect of cell pressurization
- Principal Investigator
  
  IIZUKA Kenji
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied health science
- Research Institution
  Health Sciences University of Hokkaido
Studies on the role of nitric oxide in abnormal intestinal serotonin metabolism using a model rat of intestinal damagePrincipal Investigator
- Principal Investigator
  
  HIRAFUJI Masahiko
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Health Sciences University of Hokkaido
Experimental design of ELISA for quantitative MCT4 analysis and an investigation of signal transduction cascades
- Principal Investigator
  
  IIZUKA Kenji
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied health science
- Research Institution
  Health Sciences University of Hokkaido
メタボリックシンドロームの新たなバイオマーカー開発を目指したMCT4の基礎的検討
- Principal Investigator
  
  IIZUKA Kenji
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Applied health science
- Research Institution
  Health Sciences University of Hokkaido
Intracelluar Signaling Mechanism for Stimulation of iNOS Expression in Vascular Smooth Cells by Docosahexaenoic AcidPrincipal Investigator
- Principal Investigator
  
  HAMAUE Naoya
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Health Sciences University of Hokkaido
Molecular Pharmacological Studies on Effect of Docosahexaenoic Acid on Vascular Cell FunctionsPrincipal Investigator
- Principal Investigator
  
  HIRAFUJI Masahiko
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Health Sciences University of Hokkaido
A study on the role of nitric oxide in the response of periodontal tissue to mechanical stimuli
- Principal Investigator
  
  MITANI Hideo
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  矯正・小児・社会系歯学
- Research Institution
  TOHOKU UNIVERSITY
Effects of Docosahexaenoic Acids on Vascular Cell FunctionsPrincipal Investigator
- Principal Investigator
  
  HIRAFUJI Masahiko
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Health Sciences University of Hokkaido
Studies on mechanism of exocytosis of serotonin from enterochromaffin cell
- Principal Investigator
  
  MINAMI Masaru
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Department of Pharmacology, Faculty of Pharmaceutical Sciences, Health Sciences
Control of orthodontic tooth movements by utilizing the inhibitory effect of bisphosphonates on bone resorption.
- Principal Investigator
  
  SHINODA Hisashi
- Project Period (FY)
  1992 – 1994
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  Functional basic dentistry
- Research Institution
  TOHOKU UNIVERSITY
STUDIES ON THE MECHANISM OF ENDOTOXIN-INDUCED MICROIRCULATORY DISTURBANCE IN DENTAL PULP TUSSUEPrincipal Investigator
- Principal Investigator
  
  HIRAFUJI Masahiko
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Health Sciences University of Hokkaido
  Tohoku University
Chronopharmacological study on the diurnal rhythms in bone metabolism.
- Principal Investigator
  
  SHINODA Hisashi
- Project Period (FY)
  1990 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Tohoku university
Roles of lipid mediators in the mechanism of dental pulp tissue injury induced by administration of pharmacological agentsPrincipal Investigator
- Principal Investigator
  
  HIRAFUJI Masahiko
- Project Period (FY)
  1990 – 1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Tohoku University
薬物誘発歯髄炎の発現機構における血少板活性化因子の役割に関する分子薬理学的研究Principal Investigator
- Principal Investigator
  
  平藤雅彦
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Tohoku University
Pharmacological Study on the Possible Roles of Platelet-activating Factor (PAF) in Inflammatory Process of the Dental PulpPrincipal Investigator
- Principal Investigator
  
  HIRAFUJI Masahiko
- Project Period (FY)
  1987 – 1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Functional basic dentistry
- Research Institution
  TOHOKU UNIVERSITY
The study on the role of platelet activating factor (PAF) in bone metbolism
- Principal Investigator
  
  HIDEO Mitani
- Project Period (FY)
  1987 – 1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  小児・社会系歯学
- Research Institution
  TOHOKU UNIVERSITY
Studies on increasing sensitivities in pulpal inflammatory reactions by new inflammatory mediator(PAF)
- Principal Investigator
  
  SANJOU Daisuke, OGURA YASUMI
- Project Period (FY)
  1986 – 1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Functional basic dentistry
- Research Institution
  TOHOKU UNIVERSITY

All 2014 2013 2012 2011 2010 2009

All Journal Article Presentation Book

[Book] 進化する運動科学の研究最前線2014
- Author(s)
  森田憲輝、沖田孝一、飯塚健治、平藤雅彦
- Total Pages
  406
- Publisher
  南山堂
- Data Source
  KAKENHI-PROJECT-24500864
[Journal Article] Skeletal muscle is an endocrine organ.2014
- Author(s)
  Iizuka K, Machida T, Hirafuji M
- Journal Title
  
  J Pharmacol Sci.
  
  Volume: 125 Pages: 125-131
- NAID
  130004438635
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24500864
[Journal Article] Extracellular MCT4 is a possible indicator for skeletal muscle MHC fiber type change.2014
- Author(s)
  Iizuka K, Machida T, Hirafuji M
- Journal Title
  
  Ann Clin Lab Sci.
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24500864
[Journal Article] 5-Hydroxytryptamine and its receptors in systemic vascular walls2013
- Author(s)
  Machida T, Iizuka K, Hirafuji M
- Journal Title
  
  Biological & Pharmaceutical Bulletin
  
  Volume: (in press)
- NAID
  130003361525
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590085
[Journal Article] 5-Hydroxytryptamine induces cyclooxygenase-2 in rat vascular smooth muscle cells : Mechanisms involving Src, PKC and MAPK activation2011
- Author(s)
  Machida T, Ohta M, Onoguchi A, Iizuka K, Minami M, Hirafuji M
- Journal Title
  
  European Journal of Pharmacology
  
  Volume: 656 Pages: 19-26
- DOI
  10.1016/j.ejphar.2010.12.044
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590085
[Journal Article] Entacapone, a catechol-0-methyltransferase inhibitor, improves the motor activity and dopamine content of basal gangliain a rat model of Parkinson's disease induced by Japanese encephalitis virus2010
- Author(s)
  Hamaue, N.
- Journal Title
  
  Brain Research
  
  Volume: 1309 Pages: 110-115
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590085
[Journal Article] Entacapone, a catecholO-methyltransferase inhibitor, improves the motor activity and dopamine content of basal ganglia in a rat model of Parkinson's disease induced by Japanese encephalitis virus2010
- Author(s)
  Hamaue, N, Ogata A, Terado M, Tsuchida S, Yabe I, Sasaki H, Hirafuji M, Togashi H, Aoki T
- Journal Title
  
  Brain Research
  
  Volume: 1309 Pages: 110-115
- DOI
  10.1016/j.brainres.2009.10.055
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590085
[Presentation] 圧力負荷がヒト培養骨格筋細胞の増殖と乳酸代謝に及ぼす作用2014
- Author(s)
  飯塚健治、町田拓自、平藤雅彦
- Organizer
  第87回　日本薬理学会年会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-24500864
[Presentation] 制がん剤投与によるラット pica 発現における回腸サブスタン P 動態の役割2013
- Author(s)
  町田拓自、加藤夏希、加藤信太郎、関谷沙希、伊藤舞、飯塚健治、平藤雅彦
- Organizer
  第86回日本薬理学会年会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-22590085
[Presentation] メトトレキサート投与による遅延性嘔吐発現における末梢サブスタンス P の役割2013
- Author(s)
  高塚千恵、町田麻衣子、町田拓自、平藤雅彦
- Organizer
  日本医療薬学会第23回年会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-22590085
[Presentation] 嘔吐誘発に関連する末梢および中枢のセロトニン、サブスタンス P 動態に及ぼす抗がん剤の影響2013
- Author(s)
  工藤冴、丸山康介、高木美奈子、町田拓自、飯塚健治、平藤雅彦
- Organizer
  日本薬学会北海道支部第140回例会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-22590085
[Presentation] ラット回腸での 5-HT、サブスタン P 代謝に及ぼすシクロホスファミド及び5-フルオロウラシル投与の影響2012
- Author(s)
  町田拓自、紙谷章基久、平野めぐみ、加藤信太郎、加藤夏希、浜上尚也、飯塚健治、平藤雅彦
- Organizer
  第16回活性アミンに関するワークショップ
- Place of Presentation
  札幌
- Year and Date
  2012-08-24
- Data Source
  KAKENHI-PROJECT-22590085
[Presentation] ラットにおける回腸 5-HT、サブスタン P 代謝、異味症発現に及ぼす 5-フルオロウラシル投与の影響2012
- Author(s)
  町田拓自、平野めぐみ、加藤信太郎、浜上尚也、飯塚健治、平藤雅彦
- Organizer
  第63回日本薬理学会北部会
- Place of Presentation
  新潟
- Year and Date
  2012-09-14
- Data Source
  KAKENHI-PROJECT-22590085
[Presentation] 各種制癌剤投与によるラット腸管におけるサブスタンス P 動態について2012
- Author(s)
  加藤夏希、加藤信太郎、関谷沙希、伊藤舞、町田拓自、飯塚健治、平藤雅彦
- Organizer
  日本薬学会北海道支部第138回例会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-22590085
[Presentation] シクロフォスファミドはラットパイカ行動及び回腸セロトニン代謝異常を誘導する2011
- Author(s)
  紙谷章基久、平野めぐみ、町田拓自、浜上尚也、飯塚健治、平藤雅彦
- Organizer
  第84回日本薬理学会年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-22590085
[Presentation] シクロホスファミド投与によるラット回腸セロトニン代謝亢進機序の検討2011
- Author(s)
  深井雄太、紙谷章基久、加藤信太郎、佐々木彩加、町田拓自、飯塚健治、平藤雅彦
- Organizer
  日本薬学会北海道支部第136回例会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-22590085
[Presentation] シスプラチン及びシクロホスファミド投与によるラット回腸での遅延性 5-HT、サブスタン P 代謝及び炎症反応の比較検討2011
- Author(s)
  町田拓自、紙谷章基久、平野めぐみ、加藤信太郎、浜上尚也、飯塚健治、平藤雅彦
- Organizer
  第62回日本薬理学会北部会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-22590085
[Presentation] Role of nitric oxide in methotrexate-induced abnormal 5-hydroxytryptamine metabolism and damage in the rat small intestine2010
- Author(s)
  Hirafuji M, Takano Y, Hirano M, Kamiya A, Machida T, Hamaue N, Iizuka K
- Organizer
  16th World Congress on Basic and Clinical Pharmacology
- Place of Presentation
  Copenhagen (Denmark)
- Data Source
  KAKENHI-PROJECT-22590085
[Presentation] シスプラチン投与によるラット回腸での遅延性 5-HT 代謝亢進機序の検討2010
- Author(s)
  紙谷章基久、平野めぐみ、小原祐介、町田拓自、浜上尚也、飯塚健治、平藤雅彦
- Organizer
  第61回日本薬理学会北部会
- Place of Presentation
  札幌
- Year and Date
  2010-09-10
- Data Source
  KAKENHI-PROJECT-22590085
[Presentation] エネルギー代謝指標としてのMCT4の有用性についての基礎的検討2010
- Author(s)
  飯塚健治、森田憲輝、町田拓自、平藤雅彦
- Organizer
  第38回薬物活性シンポジウム
- Place of Presentation
  札幌市教育文化会館
- Year and Date
  2010-11-12
- Data Source
  KAKENHI-PROJECT-21500690
[Presentation] 圧力負荷, 糖並びにインスリンがラットL6骨格筋細胞のMCT4に与える作用2009
- Author(s)
  須郷俊介, 飯塚健治, 森田憲輝, 町田拓自, 平藤雅彦
- Organizer
  第129回日本薬学会
- Place of Presentation
  国立京都国際会館
- Year and Date
  2009-03-28
- Data Source
  KAKENHI-PROJECT-19650191

1. SHINODA Hisashi (80014025)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
2. OGURA YASUMI (60091667)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
3. MACHIDA Takuji (90433424)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
4. IGARASHI Kaoru (70202851)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
5. MITANI Hideo (50014220)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
6. IIZUKA Kenji (10344467)

# of Collaborated Projects: 3 results

# of Collaborated Products: 6 results
7. HAMAUE Naoya (70221504)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
8. SANJOU Daisuke (70013943)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. ONODERA Kenji (40133988)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. ENDO Yasuo (50005039)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. MINAMI Masaru (00142711)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. ENDO Toru (80194041)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. YAJIMA Toshihiko (10018749)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. SAEKI Shunichi (60271954)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 足立晴紀 (50241641)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. ISHIGURO Tsuneo

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 町田拓目

# of Collaborated Projects: 0 results

# of Collaborated Products: 18 results

HIRAFUJI Masahiko 平藤 雅彦

HAMAUE Naoya 平藤 雅彦

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Studies on the role of nitric oxide in abnormal intestinal serotonin metabolism using a model rat of intestinal damagePrincipal Investigator

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Intracelluar Signaling Mechanism for Stimulation of iNOS Expression in Vascular Smooth Cells by Docosahexaenoic AcidPrincipal Investigator

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Molecular Pharmacological Studies on Effect of Docosahexaenoic Acid on Vascular Cell FunctionsPrincipal Investigator

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Effects of Docosahexaenoic Acids on Vascular Cell FunctionsPrincipal Investigator

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STUDIES ON THE MECHANISM OF ENDOTOXIN-INDUCED MICROIRCULATORY DISTURBANCE IN DENTAL PULP TUSSUEPrincipal Investigator

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Roles of lipid mediators in the mechanism of dental pulp tissue injury induced by administration of pharmacological agentsPrincipal Investigator

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薬物誘発歯髄炎の発現機構における血少板活性化因子の役割に関する分子薬理学的研究Principal Investigator

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HIRAFUJI Masahiko 平藤雅彦

HAMAUE Naoya 平藤雅彦