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OKUMURA Ken  奥村 謙

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Researcher Number 20185549
Other IDs
External Links
Affiliation (Current) 2025: 弘前大学, 医学研究科, 客員研究員
Affiliation (based on the past Project Information) *help 2016 – 2018: 弘前大学, 医学研究科, 客員研究員
2011 – 2015: 弘前大学, 医学(系)研究科(研究院), 教授
2014: 弘前大学, 大学院医学研究科, 教授
2011: 弘前大学, 医学研究科, 教授
2007 – 2011: Hirosaki University, Hirosaki University, Graduate School of Medicine, Professor … More
1996 – 2006: 弘前大学, 医学部, 教授
1993 – 1995: Kumamoto University, Department of Medicine, Associate professor, 医学部, 助教授
1992: KUMAMOTO UNIVERSITY HOSPITAL, DIVISION OF CARDIOLOGY, ASSOCIATE PROFESSOR, 医学部・附属病院, 助教授
1992: 熊本大学, 医学部附属病院, 助教授
1990 – 1991: 熊本大学, 医学部附属病院, 講師
1989: Kumamoto University, University Hospital, Lecturer, 医学部・附属病院, 講師
1988: Kumamoto University Hospital, 医学部附属病院, 講師
1987: 熊本大学, 医学部・附属病院, 講師
1986: 熊本大学, 医学部附属病院, 助手 Less
Review Section/Research Field
Principal Investigator
Circulatory organs internal medicine / Circulatory organs internal medicine / Cardiovascular medicine
Except Principal Investigator
Circulatory organs internal medicine / Circulatory organs internal medicine / Cardiovascular medicine
Keywords
Principal Investigator
L-arginine / P122蛋白 / Endothelium / 一酸化窒素 / Phospholipase C / Nitric oxide / phospholipase C / 冠攣縮 / 循環器・高血圧 / Rho A … More / phospholipase C-δ1 / coronary spastic angina / Phospholipase C-δ1 / 冠攣縮性狭心症 / slow conduction / エントレインメント / リエントリー / FK409 / Emax / coronary blood flow / nitric oxide / Coronary Circulation / Nitric Oxide / L-アルギニン / adenosine / Coronary circulation / Acetylcholine / アデノシン / 反応性充血 / 冠循環 / アセチルコリン / 内皮由来弛緩因子 / R257H亜型PLC-δ1 / antiarrhythmic drug / entrainment / idiopathic ventricular tachycardia / 遅い伝導部 / 心室性頻拍症 / 抗不整脈剤 / 遅延伝導 / 特発性心室性頻拍症 / intracellular Ca ion / p122 protein / skin fibroblast / vascular smooth muscle / 細胞内カルシウムイオン / 皮膚線維芽細胞 / 血管平滑筋細胞 / P122 protein / small G protein / Acethylcholine / Intracellular calcium / Transgenic mouse / Hypertension / Vasospastic angina / small G蛋白 / catheter ablation / verapamil / reentry / ventricular tachycardia / Caチャネル / 拡張後期電位 / 特発性心室頻拍 / カテーテルアブレーション / ベラパミル / 緩徐伝導 / 心室頻拍 / cyclic GMP / Papaverine / cardiac contractility / サイクリックGMP / パパベリン / 冠血流量 / 心筋収縮性 / reactive hyperemia / oxygen radicals / endothelium / スーパーオキシド / 冠血流 / 内皮 / L-Arginine / Acetylcoline / Endothelin / Endothelium-derived relaxing factor / エンドセリン / N^G-monomethyl-L-arginine / Reactive hyperemia / Lーarginine / Adenosine / Coronary blood flow / N^GーmonomethylーLーarginine / Lーモノメチルアルギニン / Lーアルギニン / phospholipase C / 冠孿縮 / Dhospholipase C … More
Except Principal Investigator
coupling factor 6 / prostacyclin / Coupling factor 6 / mitochondria / Hypertension / Prostacyclin / Vasoconstrictor / Mitochondria / intracellular acidosis / Acidosis / 冠動脈の攣縮 / nitric oxide / receptor / binding assay / microarray / Endothelial cells / Shear stress / colored microspheres / ヒスタミン / アセチルコリン / 狭心症 / 冠攣縮 / 冠攣縮性狭心症 / 心筋梗塞 / PAI / tーPA / fibrinolytic system / stable exertional angina / unstable angina / acute myocardial infarction / acute myocardial ischemia / reactive oxygen species / plasminogen activator inhibitor / tissue plasminogen activator / acidosis / ATP synthase / Angiotensin II / Calcium / c-Src / Vascular smooth muscle cells / hypertension / diabetes / カルシウム感受性 / カルベジロール / カルシウム / inhibitory factor 1 / lamina / inhibitory protein 1 / genomic instability / epigenetics / telomere / autophagy / aging / Atherosclerosis / Acetylcholine / Coronary Artery Spasm / FPA / マグネシウム / 動脈硬化 / one vessel disease / Ca-antagonist / Coronary artery spasm / Angina pectoris / β遮断剤 / 狭心症の発生機序 / 一枝病変 / Ca拮抗剤 / relaxin / neuregulin / estrogen receptor β / asymmetric dimethylarginine / prostaclin / end-stage renal disease / valvular heart disease / myocardial infarction / End-stage renal disease / Ischemic heart disease / 末期腎疾患 / 心臓弁膜症 / Coronary artery disease / Oxidative stress / Ventricualr Remodeling / Matrix metalloproteinase / 梗塞後リモデリング / 冠動脈疾患 / 酸化ストレス / 心室リモデリング / マトリクスメタロプロテアーゼ / Shear atress / regional myocardial blood flow / acidic gelatin hydrogel microspheres / coronary collateral circulation / basic fibroblast growth factor / colored microsphere / 局所心筋血流量 / 酸性ハイドロゲル粒子 / 冠側副血行循環 / 塩基性線維芽細胞増殖因子 / VARIANT ANGINA / MAGNESIUM / FIHRINOPEPTIDE A / ENDITHELIN / CORONARY THROMBOSIS / CORONARY SAPSM / ACUTE MYOCARDIAL INFARCTION / ACETYLCHOLINE / サブスタンスP / 冠循環 / エンドセリン / フィブリノペプチドA / Mg / 冠攣縮硬化 / oxygenーderived free radical / tPAーPAI complex / angina / 血小板由来増殖因子 / 不安定狭心症 / cardiac hypertrophy / ATPase IF1 / HUVEC / HEK293 / IF1 / Antibody / Arteriole / ATP / Microarray / Vascular smooth muscle cell / Efrapeptin / Arachidonic acid / Wister Kyoto rat / Sponteneously hypertensive rat / Spontaneously hypertensive rat / Mesenteric arteriole / 房室結節 / リエントリー / 房室弁輪 / 心房性頻拍 / Salt / Exercise / UCG / Phospholamban / SERCA2 / pressure overload / Congestive heart failure / transgenic mouse / heart failure / hypertrophy / transverse aortic constriction / exercise / WKY / SHR / nitric oxide transgenic mouse / salt Less
  • Research Projects

    (28 results)
  • Research Products

    (258 results)
  • Co-Researchers

    (35 People)
  •  Elucidation of novel mechanism and development of treatment strategy for coronary spastic angina through regulation of calcium sensitization

    • Principal Investigator
      Tomita Hirofumi
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Cardiovascular medicine
    • Research Institution
      Hirosaki University
  •  Elucidation of mechanism for coupling factor 6-induced accelerated aging and identification of its inhibitory protein

    • Principal Investigator
      OSANAI TOMOHIRO
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Cardiovascular medicine
    • Research Institution
      Hirosaki University
  •  Molecular biological approach to the pathogenesis of coronary spastic angina: A study on the role of p122 proteinPrincipal Investigator

    • Principal Investigator
      Okumura Ken
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Cardiovascular medicine
    • Research Institution
      Hirosaki University
  •  Establishment of regulatory system against coupling factor 6-induced vascular damage

    • Principal Investigator
      OSANAI Tomohiro
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Hirosaki University
  •  Molecular biological approach to the pathogenesis of coronary spastic angina: A study on the role of p122 proteinPrincipal Investigator

    • Principal Investigator
      OKUMURA Ken
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Hirosaki University
  •  Analysis of the mechanism and the tachycardia circuit of the atrial tachycardia originating from the atrioventricular annulus

    • Principal Investigator
      YAMABE Hiroshige
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Kumamoto University
  •  Estimation of coupling factor 6-induced vascular damage and utilization for drug discovery

    • Principal Investigator
      OSANAI Tomohiro
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Hirosaki University
  •  Role of novel vasoconstrictor coupling factor 6 in the pathogenesis of cardiac hypertrophy and cardiac failure

    • Principal Investigator
      SASAKI Singo
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Hirosaki University
  •  Clinical and molecular biological approach to the genesis of coronary artery spasm : A study on the role of p122 proteinPrincipal Investigator

    • Principal Investigator
      OKUMURA Ken
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Hirosaki University
  •  Functional analysis of novel vasoconstrictor coupling factor 6 and clarification of mechanism for the genesis of cardiovascular disorders

    • Principal Investigator
      OSANAI Tomohiro
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Hirosaki University
  •  Clinical, Molecular and Biological Studies to the Genesis of Coronary Spastic AnginPrincipal Investigator

    • Principal Investigator
      OKUMURA Ken
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Hirosaki University
  •  Functional analysis of novel vasoconstrictor coupling factor 6 and its role in pathophysiology

    • Principal Investigator
      OSANAI Tomohiro
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Hirosaki University
  •  Molecular and Biological Approaches to the Genesis of Coronary Spastic Angina : With special reference to the intracellular signaling pathway participating coronary artery contractionPrincipal Investigator

    • Principal Investigator
      OKAMURA Ken
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Hirosaki University
  •  The role of matrix metalloproteinase on angiogenesis and ventricular remodeling after acute myocardial infarction

    • Principal Investigator
      MATSUNAGA Toshiro
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Hirosaki University
  •  A study on the role of coupling factor 6 in the pathogenesis of heart disease

    • Principal Investigator
      OSANAI Tomohiro
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Hirosaki University
  •  Role of coupling factor 6 in the pathogenesis of cardiovascular disease

    • Principal Investigator
      OSANAI Tomohiro
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Hirosaki University
  •  A Study on the mechanism and treatment of verapamil-sensitive idiopathic ventricular tachycardiaPrincipal Investigator

    • Principal Investigator
      OKUMURA Ken
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Hirosaki University
  •  A Study on the Effect of Nitric Oxide on Myocardial Oxygen Consumption and Cardiac ContractilityPrincipal Investigator

    • Principal Investigator
      OKUMURA Ken
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      HIROSAKI UNIVERSITY
  •  A study of the effects of intramyocardial delivery of basic fibroblast growth factor-impregnated gelatin hydrogel microspheres on the enhancement of coronary collateral circulation.

    • Principal Investigator
      HANADA Hiroyuki
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      HIROSAKI UNIVERSITY
  •  A Study on the Regulation of CoronaryBlood Flow in the condition of Inhabited Synthesis of Endothelium-Derived Nitric OxidePrincipal Investigator

    • Principal Investigator
      OKUMURA Ken
    • Project Period (FY)
      1996 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Hirosaki University
  •  Role of endothelium-derived nitric oxide on regulation of coronary blood flowPrincipal Investigator

    • Principal Investigator
      OKUMURA Ken
    • Project Period (FY)
      1994 – 1995
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Kumamoto University
  •  A study of the roles of endothelium-derived relaxing factor and endothelin in the regulation of coronary blood flow.In vivo experiments.Principal Investigator

    • Principal Investigator
      OKUMURA Ken
    • Project Period (FY)
      1992 – 1993
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Kumamoto University
  •  PATHOGENESIS AND CLINICAL SIGNIFICANCE OF CORONARY SPASM

    • Principal Investigator
      YASUE Hirofumi
    • Project Period (FY)
      1991 – 1992
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      KUMAMOTO UNIVERSITY HOSPITAL
  •  IN Vivo Study on Coronary Circulation Under Pharmacologic Inhibition of Endothelium-Derived Relaxing FactorPrincipal Investigator

    • Principal Investigator
      OKUMURA Ken
    • Project Period (FY)
      1990 – 1991
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Kumamoto University
  •  The changes of fibrinolytic system and reactive oxygen species production during acute myocardial ischemia

    • Principal Investigator
      OGAWA Hisao
    • Project Period (FY)
      1990 – 1991
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Kumamoto University
  •  Mechanism of idiopathic ventricular tachycardia of the left ventricular origin and the effect of antiarrhythmic agents on it. A study using an entrainment phenomenon.Principal Investigator

    • Principal Investigator
      OKUMURA Ken
    • Project Period (FY)
      1988 – 1989
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Kumamoto University
  •  Study on the Pathogenesis of Coronary Artery Spasm

    • Principal Investigator
      YASUE Hirofumi
    • Project Period (FY)
      1986 – 1988
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Kumamoto University
  •  A Study on Pathogenesis and Treatment of Angina Pectoris

    • Principal Investigator
      YASUE Hirofumi
    • Project Period (FY)
      1985 – 1986
    • Research Category
      Grant-in-Aid for General Scientific Research (A)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Kumamoto University

All 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 Other

All Journal Article Presentation Book

  • [Book] 心房細動の治療と管理Q&A第2版2009

    • Author(s)
      奥村謙
    • Total Pages
      3
    • Data Source
      KAKENHI-PROJECT-20590856
  • [Book] 心房細動の治療と管理Q&A第2版2009

    • Author(s)
      奥村謙
    • Total Pages
      306
    • Publisher
      医学書院
    • Data Source
      KAKENHI-PROJECT-20590856
  • [Book] 頻拍発症機序の解析法(新・心臓病プラクティス13)2009

    • Author(s)
      奥村謙
    • Data Source
      KAKENHI-PROJECT-20590856
  • [Book] 心房細動の治療と管理Q&A第2版2009

    • Author(s)
      奥村謙, 他
    • Total Pages
      306
    • Publisher
      医学書院
    • Data Source
      KAKENHI-PROJECT-20590856
  • [Book] 心臓リズムマネージメントを究める2009

    • Author(s)
      奥村謙, 他
    • Total Pages
      473
    • Publisher
      メジカルビュー社
    • Data Source
      KAKENHI-PROJECT-20590856
  • [Book] 心臓リズムマネージメントを究める2009

    • Author(s)
      奥村謙
    • Publisher
      メジカルビュー社
    • Data Source
      KAKENHI-PROJECT-20590856
  • [Book] 頻拍発症機序の解析法新・心臓病プラクティス132009

    • Author(s)
      奥村謙, 他
    • Total Pages
      519
    • Publisher
      文光堂
    • Data Source
      KAKENHI-PROJECT-20590856
  • [Book] ステップで判読「心電図」2007

    • Author(s)
      奥村 謙
    • Total Pages
      206
    • Publisher
      南江堂
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18590758
  • [Book] シミュレイション内科 : 心筋梗塞・狭心症を探る2006

    • Author(s)
      奥村 謙
    • Total Pages
      256
    • Publisher
      永井書店
    • Data Source
      KAKENHI-PROJECT-18590758
  • [Book] 狭心症、内科學(杉本恒明ほか編集)2003

    • Author(s)
      奥村 謙
    • Total Pages
      2297
    • Publisher
      朝倉書店
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15590712
  • [Journal Article] Rivaroxaban, a Direct Factor Xa Inhibitor, Ameliorates Hypertensive Renal Damage Through Inhibition of the Inflammatory Response Mediated by Protease-Activated Receptor Pathway2019

    • Author(s)
      Ichikawa H, Shimada M, Narita M, Narita I, Kimura Y, Tanaka M, Osanai T, Okumura K, Tomita H.
    • Journal Title

      Journal of the American Heart Association

      Volume: 8 Issue: 8

    • DOI

      10.1161/jaha.119.012195

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K09489, KAKENHI-PROJECT-19K08530
  • [Journal Article] Blood pressure-independent effect of olmesartan on albuminuria in mice overexpressing renin: Its beneficial role in the ACE2/Ang (1-7)/Mas axis and NADPH oxidase expression.2018

    • Author(s)
      Ichikawa H, Narita I, Narita M, Tanno T, Yokono Y, Kimura Y, Tanaka M, Osanai T, Okumura K, Tomita H
    • Journal Title

      Int Heart J

      Volume: 印刷中

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K09489
  • [Journal Article] Novel anti-aging gene NM_026333 contributes to proton-induced aging via NCX1-pathway2018

    • Author(s)
      Osanai T, Tanaka M, Mikami K, Kitajima M, Tomisawa T, Magota K, Tomita H, Okumura K.
    • Journal Title

      Journal of Molecular and Cellular Cardiology

      Volume: 125 Pages: 174-184

    • DOI

      10.1016/j.yjmcc.2018.10.021

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K09489
  • [Journal Article] Safety and Efficacy of Subcutaneous Cardioverter Defibrillator in Patients at High Risk of Sudden Cardiac Death ― Primary Japanese Experience ―2018

    • Author(s)
      Sasaki S, Tomita H, Tsurugi T, Ishida Y, Shoji Y, Nishizaki K, Kinjo T, Endo T, Nishizaki F,Hanada K, Sasaki K, Horiuchi D, Kimura M, Higuma T, Okamatsu H, Tanaka Y, Koyama J, Okumura K.
    • Journal Title

      Circ J

      Volume: 82 Issue: 6 Pages: 1546-1551

    • DOI

      10.1253/circj.CJ-17-1001

    • NAID

      130006744337

    • ISSN
      1346-9843, 1347-4820
    • Year and Date
      2018-05-25
    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K09489
  • [Journal Article] The relationship of serum eicosapentaenoic acid levels with J-waves in a general population: Analysis of the Iwaki Health Promotion Project.2018

    • Author(s)
      Kimura Y, Yamada, M, Hanada K, Endo T, Narita N, Narita M, Senoo M, Yonekura M, Ichikawa H, Kurauchi S, Nakaji S, Okumura K, Tomita H.
    • Journal Title

      Int Heart J

      Volume: 印刷中

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K09489
  • [Journal Article] Mitochondrial inhibitory factor protein 1 attenuates coupling factor 6-induced?aging signal2018

    • Author(s)
      Osanai Tomohiro、Tanaka Makoto、Mikami Kasumi、Kitajima Maiko、Magota Koji、Tomita Hirofumi、Okumura Ken
    • Journal Title

      Journal of Cellular Biochemistry

      Volume: 印刷中 Issue: 7 Pages: 6194-6203

    • DOI

      10.1002/jcb.26828

    • Data Source
      KAKENHI-PROJECT-16K09489
  • [Journal Article] Impact of Atrial Natriuretic Peptide Value for Predicting Paroxysmal Atrial Fibrillation in Ischemic Stroke Patients.2017

    • Author(s)
      Shiroto H, Tomita H, Hagii J, Metoki N, Fujita A, Kamada T, Takahashi K, Saito S, Sasaki S, Hitomi H, Seino S, Baba Y, Uchizawa T, Iwata M, Matsumoto S, Yasujima M, Okumura K.
    • Journal Title

      J Stroke Cerebrovasc Dis

      Volume: 26 Issue: 4 Pages: 772-778

    • DOI

      10.1016/j.jstrokecerebrovasdis.2016.10.016

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K09489
  • [Journal Article] Enhanced transient receptor potential channel-mediated Ca2+ influx in the cells with phospholipase C-δ1 overexpression: its possible role in coronary artery spasm.2017

    • Author(s)
      Murakami K, Osanai T, Tanaka M, Nishizaki K, Kinjo T, Tanno T, Ishida Y, Suzuki A, Endo T, Tomita H, Okumura K.
    • Journal Title

      Fundam Clin Pharmacol.

      Volume: 印刷中 Issue: 4 Pages: 383-391

    • DOI

      10.1111/fcp.12269

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26461120, KAKENHI-PROJECT-16K09489
  • [Journal Article] Safety and efficacy of contemporary catheter ablation for atrial fibrillation patients with a history of cardioembolic stroke in the era of direct oral anticoagulants.2017

    • Author(s)
      Nishizaki K, Itoh T, Kimura M, Tsushima Y, Shoji Y, Kinjo T, Ishida Y, Sasaki K, Horiuchi D, Sasaki S, Tomita H, Okumura K.
    • Journal Title

      J Cardiol

      Volume: 70 Issue: 1 Pages: 86-91

    • DOI

      10.1016/j.jjcc.2016.10.001

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K09489
  • [Journal Article] Potential roles of the wearable cardioverter-defibrillator in acute phase care of patients at high risk of sudden cardiac death: A single-center Japanese experience.2017

    • Author(s)
      Sasaki S, Shoji Y, Ishida Y, Kinjo T, Tsushima Y, Seno M, Nishizaki F, Itoh T, Izumiyama K, Yokota T, Yokoyama H, Yamada M, Horiuchi D, Kimura M, Higuma T, Tomita H, Okumura K.
    • Journal Title

      J Cardiol.

      Volume: 69 Issue: 1 Pages: 359-363

    • DOI

      10.1016/j.jjcc.2016.08.004

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K09489
  • [Journal Article] Enhanced transient receptor potential channel-mediated Ca2+ influx in the cells with phospholipase C-delta1 overexpression: its possible role in coronary artery spasm.2017

    • Author(s)
      Murakami K, Osanai T, Tanaka M, Nishizaki K, Kinjo T, Tanno T, Ishida Y, Suzuki A, Endo T, Tomita H, Okumura K.
    • Journal Title

      Fundam Clin Pharmacol.

      Volume: 31 Pages: 383-391

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K09151
  • [Journal Article] Modified sympatheticsympathetic nerve regulation in AKAP5-null mice.2016

    • Author(s)
      Han C, Tomita H, Ohba T, Nishizaki K, Ogata Y, Matsuzaki Y, Sawamura D, Yanagisawa T, Osanai T, Imaizumi T, Matsubara A, Adachi T, Ono K, Okumura K, Murakami M.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 469(4) Issue: 4 Pages: 897-902

    • DOI

      10.1016/j.bbrc.2015.12.057

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26461120, KAKENHI-PROJECT-26461675
  • [Journal Article] Olmesartan inhibits cardiac hypertrophy in mice overexpressing renin independently of blood pressure: its beneficial effects on ACE2/Ang(1-7)/Mas axis and NADPH oxidase expression.2016

    • Author(s)
      Tanno T, Tomita H, Narita I, Kinjo T, Nishizaki K, Ichikawa H, Kimura Y, Tanaka M, Osanai T, Okumura K.
    • Journal Title

      J Cardiovasc Pharmacol.

      Volume: 67 Pages: 503-509

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15K09151
  • [Journal Article] Effect of rivaroxaban on prothrombin fragment 1+2 compared with warfarin in patients with acute cardioembolic stroke: Insight from its serial measurement.2016

    • Author(s)
      Hagii J, Tomita H, Metoki N, Tamai Y, Saito S, Shiroto H, Hitomi H, Kamada T, Seino S, Takahashi K, Sasaki S, Yasujima M, Okumura K.
    • Journal Title

      Thromb Res.

      Volume: 148 Pages: 9-14

    • DOI

      10.1016/j.thromres.2016.10.011

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K09489
  • [Journal Article] Reduced residual conduction gaps and favourable outcome in contact force-guided circumferential pulmonary vein isolation.2016

    • Author(s)
      Itoh T, Kimura M, Tomita H, Sasaki S, Owada S, Horiuchi D, Sasaki K, Ishida Y, Kinjo T, Okumura K.
    • Journal Title

      Europace.

      Volume: 18 Issue: 4 Pages: 531-537

    • DOI

      10.1093/europace/euv206

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26461120
  • [Journal Article] Olmesartan Inhibits Cardiac Hypertrophy in Mice Overexpressing Renin Independently of Blood Pressure: Its Beneficial Effects on ACE2/Ang(1-7)/Mas Axis and NADPH Oxidase Expression.2016

    • Author(s)
      Tanno T, Tomita H, Narita I, Kinjo T, Nishizaki K, Ichikawa H, Kimura Y, Tanaka M, Osanai T, Okumura K.
    • Journal Title

      J Cardiovasc Pharmacol.

      Volume: 67 Issue: 6 Pages: 503-509

    • DOI

      10.1097/fjc.0000000000000374

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26461120, KAKENHI-PROJECT-16K09489
  • [Journal Article] Modified sympathetic nerve regulation in AKAP5-null mice.2016

    • Author(s)
      Han C, Tomita H, Ohba T, Nishizaki K, Ogata Y, Matsuzaki Y, Sawamura D, Yanagisawa T, Osanai T, Imaizumi T, Matsubara A, Adachi T, Ono K, Okumura K, Murakami M
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 469 Pages: 897-902

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15K09151
  • [Journal Article] NF-κB-dependent increase in tissue factor expression is responsible for hypoxic podocyte injury.2016

    • Author(s)
      Narita I, Shimada M, Yamabe H, Kinjo T, Tanno T, Nishizaki K, Kawai M, Nakamura M, Murakami R, Nakamura N, Tomita H, Saleem MA, Mathieson PW, Okumura K.
    • Journal Title

      Clin Exp Nephrol.

      Volume: 20 Pages: 679-688

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K09489
  • [Journal Article] NF-κB-dependent increase in tissue factor expression is responsible for hypoxic podocyte injury.2016

    • Author(s)
      Narita I, Shimada M, Yamabe H, Kinjo T, Tanno T, Nishizaki K, Kawai M, Nakamura M, Murakami R, Nakamura N, Tomita H, Saleem MA, Mathieson PW, Okumura K.
    • Journal Title

      Clin Exp Nephrol.

      Volume: 20 Issue: 5 Pages: 679-688

    • DOI

      10.1007/s10157-015-1214-z

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26461120
  • [Journal Article] Mitochondrial Inhibitory Factor Protein 1 Functions as an Endogenous Inhibitor for Coupling Factor 6.2016

    • Author(s)
      Kawai M, Osanai T, Tanaka M, Magota K, Tomita H, Okumura K.
    • Journal Title

      J Cell Biochem

      Volume: 117 Pages: 1680-1687

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15K09151
  • [Journal Article] Catheter ablation of ventricular arrhythmias arising from the basal septum of the right ventricle: characteristics and significance of junctional rhythm appearing during ablation.2016

    • Author(s)
      Sasaki K, Sasaki S, Kimura M, Horiuchi D, Itoh T, Ishida Y, Kinjo T, Tomita H, Okumura K.
    • Journal Title

      J Interv Card Electrophysiol

      Volume: 45 Issue: 2 Pages: 159-167

    • DOI

      10.1007/s10840-015-0095-0

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26461120
  • [Journal Article] Mitochondrial Inhibitory Factor Protein 1 Functions as an Endogenous Inhibitor for Coupling Factor 6.2016

    • Author(s)
      Kawai M, Osanai T, Tanaka M, Magota K, Tomita H, Okumura K.
    • Journal Title

      J Cell Biochem.

      Volume: 117 Issue: 7 Pages: 1680-1687

    • DOI

      10.1002/jcb.25461

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26461120, KAKENHI-PROJECT-16K09489
  • [Journal Article] Enhanced p122RhoGAP/DLC-1 expression can be a cause of coronary spasm.2015

    • Author(s)
      Kinjo T, Tanaka M, Osanai T, Shibutani S, Narita I, Tanno T, Nishizaki K, Ichikawa H, Kimura Y, Ishida Y, Yokota T, Shimada M, Homma Y, Tomita H, Okumura K.
    • Journal Title

      PLOS ONE

      Volume: 10(12) Issue: 12 Pages: e0143884-e0143884

    • DOI

      10.1371/journal.pone.0143884

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26461120, KAKENHI-PROJECT-25860577
  • [Journal Article] CHA2DS2-VASc and HAS-BLED scores and activated partial thromboplastin time for prediction of high plasma concentration of dabigatran at trough.2015

    • Author(s)
      Owada S, Tomita H, Kinjo T, Ishida Y, Itoh T, Sasaki K, Horiuchi D, Kimura M, Sasaki S, Okumura K.
    • Journal Title

      Thorombosis Res.

      Volume: 135 Issue: 1 Pages: 62-67

    • DOI

      10.1016/j.thromres.2014.10.025

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26461120
  • [Journal Article] Enhanced p122RhoGAP/DLC-1 Expression Can Be a Cause of Coronary Spasm2015

    • Author(s)
      Kinjo T, Tanaka M, Osanai T, Shibutani S, Narita I, Tanno T, Nishizaki K, Ichikawa H, Kimura Y, Ishida Y, Yokota T, Shimada M, Homma Y, Tomita H, Okumura K
    • Journal Title

      PLoS One

      Volume: 10

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K09151
  • [Journal Article] Deeply reinverted T wave at 14 days after the onset of first anterior acute myocardial infarction predicts improved left ventricular function at 6 months.2015

    • Author(s)
      Yokoyama H, Tomita H, Nishizaki F, Hanada K, Shibutani S, Yamada M, Abe N, Higuma T, Osanai T, Okumura K
    • Journal Title

      Clin Cardiol

      Volume: 38 Pages: 157-163

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K09151
  • [Journal Article] Plasma Soluble Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 as a Novel Prognostic Biomarker in Patients With ST-Segment Elevation Acute Myocardial Infarction2015

    • Author(s)
      Higuma T, Abe N, Tateyama S, Endo T, Shibutani S, Yokoyama H, Hanada K, Yamada M, Tomita H, Hanada H, Osanai T, Kume N, Okumura K.
    • Journal Title

      Circ J

      Volume: 79 Issue: 3 Pages: 641-648

    • DOI

      10.1253/circj.CJ-14-0904

    • NAID

      130004927094

    • ISSN
      1346-9843, 1347-4820
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26461120
  • [Journal Article] Validation of Risk Scoring System Excluding Female Sex From CHA<sub>2</sub>DS<sub>2</sub>-VASc in Japanese Patients With Nonvalvular Atrial Fibrillation – Subanalysis of the J-RHYTHM Registry –2015

    • Author(s)
      Tomita H, Okumura K, Inoue H, Atarashi H, Yamashita T, Origasa H, Tsushima E, on behalf of the J-RHYTHM Registry Investigators.
    • Journal Title

      Circ J

      Volume: 79 Issue: 8 Pages: 1719-1726

    • DOI

      10.1253/circj.CJ-15-0095

    • NAID

      130005089373

    • ISSN
      1346-9843, 1347-4820
    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26461120
  • [Journal Article] Deeply re-inverted T-wave at 14 days after the onset of first anterior acute myocardial infarction predicts improved left ventricular function at 6 months.2015

    • Author(s)
      Yokoyama H, Tomita H, Nishizaki F, Hanada K, Shibutani S, Yamada M, Abe N, Higuma T, Osanai T, Okumura K.
    • Journal Title

      Clin Cardiol.

      Volume: 38 Issue: 3 Pages: 157-163

    • DOI

      10.1002/clc.22366

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26461120
  • [Journal Article] Impact of Sex Difference on Severity and Functional Outcome in Patients with Cardioembolic Stroke2015

    • Author(s)
      Tomita H, Hagii J, Metoki N, Saito S, Shiroto H, Hitomi H, Kamada T, Seino S, Takahashi K, Baba Y, Sasaki S, Uchizawa T, Iwata M, Matsumoto S, Shoji Y, Tanno T, Osanai T, Yasujima M, Okumura K.
    • Journal Title

      J Stroke Cerebrovasc Dis

      Volume: 24 Pages: 2613-2618

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K09151
  • [Journal Article] Plasma Soluble Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 as a Novel Prognostic Biomarker in Patients With ST-Segment Elevation Acute Myocardial Infarction.2015

    • Author(s)
      Higuma T, Abe N, Tateyama S, Endo T, Shibutani S, Yokoyama H, Hanada K, Yamada M, Tomita H, Hanada H, Osanai T, Kume N, Okumura K.
    • Journal Title

      Circ J

      Volume: 79 Pages: 641-648

    • NAID

      130004927094

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K09151
  • [Journal Article] Severity and Functional Outcome of Patients with Cardioembolic Stroke Occurring during Non-vitamin K Antagonist Oral Anticoagulant Treatment.2015

    • Author(s)
      Tomita H, Hagii J, Metoki N, Saito S, Shiroto H, Hitomi H, Kamada T, Seino S, Takahashi K, Sasaki S, Yasujima M, Okumura K.
    • Journal Title

      J Stroke Cerebrovasc Dis

      Volume: 24 Pages: 1430-7

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26461120
  • [Journal Article] &ndash; An Analysis of the J-RHYTHM Registry &ndash;2014

    • Author(s)
      Okumura K, Inoue H, Atarashi H, Yamashita T, Tomita H, Origasa H, for the J-RHYTHM Registry Investigators.
    • Journal Title

      Circ J

      Volume: 78 Issue: 7 Pages: 1593-1599

    • DOI

      10.1253/circj.CJ-14-0144

    • NAID

      130003391135

    • ISSN
      1346-9843, 1347-4820
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591077, KAKENHI-PROJECT-26670957
  • [Journal Article] Impact of gender on the prognosis of patients with nonvalvular atrial fibrillation.2014

    • Author(s)
      Inoue H, Atarashi H, Okumura K, Yamashita T, Origasa H, Kumagai N, Sakurai M, Kawamura Y, Kubota I, Matsumoto K, Kaneko Y, Ogawa S, Aizawa Y, Chinushi M, Kodama I, Watanabe E, Koretsune Y, Okuyama Y, Shimizu A, Igawa O, Bando S, Fukatani M, Saikawa T, Chishaki A; J-RHYTHM Registry Investigators.
    • Journal Title

      Am J Cardiol.

      Volume: 113 Issue: 6 Pages: 957-962

    • DOI

      10.1016/j.amjcard.2013.11.057

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591077, KAKENHI-PROJECT-25461043, KAKENHI-PROJECT-26670957
  • [Journal Article] 8-Methyltryptanthrin-induced differentiation of P19CL6 embryonal carcinoma cells into spontaneously beating cardiomyocyte-like cells.2014

    • Author(s)
      Seya K, Yamaya A, Kamachi S, Murakami M, Kitahara H, Kawakami J, Okumura K, Murakami M, Motomura S, Furukawa K.
    • Journal Title

      8-Methyltryptanthrin-induced differentiation of P19CL6 embryonal carcinoma cells into spontaneously beating cardiomyocyte-like cells.

      Volume: 77 Issue: 6 Pages: 1413-9

    • DOI

      10.1021/np500108r

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-25460293, KAKENHI-PROJECT-26461120
  • [Journal Article] High correlation of estimated local conduction velocity with natural logarithm of bipolar electrogram amplitude in the reentry circuit of atrial flutter.2014

    • Author(s)
      Itoh T, Kimura M, Sasaki S, Owada S, Horiuchi D, Sasaki K, Ishida Y, Takahiko K, Okumura K.
    • Journal Title

      J Cardiovasc Electrophysiol.

      Volume: 25 Issue: 4 Pages: 387-394

    • DOI

      10.1111/jce.12329

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591077
  • [Journal Article] Syncope in high-risk cardiomyopathy patients with implantable defibrillators: frequency, risk factors, mechanisms, and association with mortality: results from the multicenter automatic defibrillator implantation trial-reduce inappropriate therapy (MADIT-RIT) study.2014

    • Author(s)
      Ruwald MH, Okumura K, Kimura T, Aonuma K, Shoda M, Kutyifa V, Ruwald AC, McNitt S, Zareba W, Moss AJ.
    • Journal Title

      Circulation.

      Volume: 129 Issue: 5 Pages: 545-552

    • DOI

      10.1161/circulationaha.113.004196

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591077
  • [Journal Article] Prognostic impact of atrial fibrillation in patients with acute myocardial infarction.2014

    • Author(s)
      Tateyama S, Higuma T, Endo T, Shibutani S, Hanada K, Yokoyama H, Yamada M, Abe N, Sasaki S, Kimura M, Okumura K.
    • Journal Title

      Journal of Arrhythmia

      Volume: 30 Issue: 6 Pages: 460-465

    • DOI

      10.1016/j.joa.2013.12.006

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26461120
  • [Journal Article] Coupling factor 6 attenuates CXCR4 expression through the HIF-1α and c-Src pathways and promotes endothelial apoptosis and inflammation.2014

    • Author(s)
      Suzuki A, Osanai T, Tanaka M, Tomita H, Magota K, Okumura K
    • Journal Title

      Hypertens Res

      Volume: 37 Pages: 708-715

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-24591089
  • [Journal Article] Coupling factor 6 attenuates CXCR4 expression through the HIF-1α and c-Src pathways and promotes endothelial apoptosis and inflammation.2014

    • Author(s)
      Suzuki A, Osanai T, Tanaka M, Tomita H, Magota K, Okumura K.
    • Journal Title

      Hypertens Res.

      Volume: 37 Issue: 8 Pages: 708-715

    • DOI

      10.1038/hr.2014.65

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26461120
  • [Journal Article] – A Single-Center Primary Experience –2014

    • Author(s)
      Sasaki S, Tomita H, Shibutani S, Izumiyama K, Higuma T, Itoh T, Sasaki S, Horiuchi D, Kimura M, Okumura K.
    • Journal Title

      Circ J

      Volume: 78 Issue: 12 Pages: 2987-2989

    • DOI

      10.1253/circj.CJ-14-1098

    • NAID

      130004704003

    • ISSN
      1346-9843, 1347-4820
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26461120
  • [Journal Article] Comparison of lesion formation between contact force-guided and non-guided circumferential pulmonary vein isolation: A prospective, randomized study.2014

    • Author(s)
      Kimura M, Sasaki S, Owada S, Horiuchi D, Sasaki K, Itoh T, Ishida Y, Kinjo T, Tomita H, Okumura K.
    • Journal Title

      Heart Rhythm.

      Volume: in press Issue: 6 Pages: 984-991

    • DOI

      10.1016/j.hrthm.2014.03.019

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591077, KAKENHI-PROJECT-26461120
  • [Journal Article] Effect of coupling factor 6 on chemokine receptors in vascular endothelial cells.2014

    • Author(s)
      Suzuki A, Osanai T, Tanaka M, Endo T, Murakami K, Tomita H, Okumura K
    • Journal Title

      Hirosaki Med J

      Volume: 64 Pages: 119-127

    • NAID

      110009838217

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24591089
  • [Journal Article] Re-elevation of T-wave from day 2 to day 4 after successful percutaneous coronary intervention predicts chronic cardiac systolic dysfunction in patients with first anterior acute myocardial infarction.2013

    • Author(s)
      Nishizaki F, Tomita H, Yokoyama H, Higuma T, Abe N, Suzuki A, Endo T, Tateyama S, Ishida Y, Osanai T, Okumura K.
    • Journal Title

      Heart Vessels.

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591077
  • [Journal Article] Re-elevation of T-wave from day 2 to day 4 after successful percutaneous coronary intervention predicts chronic cardiac systolic dysfunction in patients with first anterior acute myocardial infarction2013

    • Author(s)
      Nishizaki F, Tomita H, Yokoyama H, Higuma T, Abe N, Suzuki A, Endo T, Tateyama S, Ishida Y, Osanai T, Okumura K
    • Journal Title

      Heart Vessels

      Volume: 28 Pages: 704-713

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24591089
  • [Journal Article] A case of myeloperoxidase anti-neutrophil cytoplasmic antibody (MPO-ANCA)-associated glomerulonephritis and concurrent membranous nephropathy.2013

    • Author(s)
      Shimada M, Fujita T, Nakamura N, Narita I, Shimaya Y, Murakami R, Yamabe H, Osawa H, Okumura K.
    • Journal Title

      BMC Nephrol.

      Volume: 14 Issue: 1 Pages: 73-73

    • DOI

      10.1186/1471-2369-14-73

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591077
  • [Journal Article] Coupling factor 6 enhances the spontaneous microaggregation of platelets by decreasing cytosolic cAMP irrespective of antiplatelet therapy.2013

    • Author(s)
      Sukekawa T, Osanai T, Nishizaki F, Metoki N, Hagii J, Kamada T, Yasujima M, Tomita H, Magota K, Okumura K.
    • Journal Title

      Hypertens Res

      Volume: 36 Pages: 520-527

    • NAID

      10031189656

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24591089
  • [Journal Article] The long-term survival of a thymic carcinoma patient treated with S-1: a case report and literature review.2013

    • Author(s)
      Tanaka H, Morimoto T, Taima K, Tanaka Y, Nakamura K, Hayashi A, Kurose A, Okumura K, Takanashi S.
    • Journal Title

      Onco Targets Ther.

      Volume: 7 Pages: 87-90

    • DOI

      10.2147/ott.s54843

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591077
  • [Journal Article] Revisit of typical counterclockwise atrial flutter wave in the ECG: electroanatomic studies on the determinants of the morphology.2013

    • Author(s)
      Sasaki K, Sasaki S, Kimura M, Owada S, Horiuchi D, Itoh T, Ishida Y, Okumura K.
    • Journal Title

      Pacing Clin Electrophysiol.

      Volume: 36 Issue: 8 Pages: 978-987

    • DOI

      10.1111/pace.12129

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591077
  • [Journal Article] Cytosolic Ca^<2+>-induced apoptosis in rat cardiomyocytes via mitochondrial NO-cGMP-protein kinase G pathway2013

    • Author(s)
      Seya K, Ono K, Fujisawa S, Okumura K, Motomura S, Furukawa K.
    • Journal Title

      J Pharmacol Exp Ther

      Volume: 344(1) Issue: 1 Pages: 77-84

    • DOI

      10.1124/jpet.112.198176

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22500363, KAKENHI-PROJECT-23591077, KAKENHI-PUBLICLY-23136501
  • [Journal Article] Validation of accuracy of three-dimensional left atrial CartoSoundTM and CT image integration: influence of respiratory phase and cardiac cycle.2013

    • Author(s)
      Kimura M, Sasaki S, Owada S, Horiuchi D, Sasaki K, Itoh T, Ishida Y, Kinjo T, Okumura K.
    • Journal Title

      J Cardiovasc Electrophysiol.

      Volume: 24 Issue: 9 Pages: 10002-10007

    • DOI

      10.1111/jce.12170

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591077
  • [Journal Article] Clinical application of immunocytochemical detection of ALK rearrangement on cytology slides for detection or screening of lung adenocarcinoma2013

    • Author(s)
      Tanaka H, Tone K, Hayashi A, Morimoto T, Taima K, Tanaka Y, Nakagawa H, Takanashi S, Okumura K, Kurose A
    • Journal Title

      Lung Cancer

      Volume: 80 Issue: 3 Pages: 289-292

    • DOI

      10.1016/j.lungcan.2013.03.006

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590472, KAKENHI-PROJECT-23591077
  • [Journal Article] Re-elevation of T-wave from day 2 to day 4 after successful percutaneous coronary intervention predicts chronic cardiac systolic dysfunction in patients with first anterior acute myocardial infarction.2013

    • Author(s)
      Nishizaki F, Tomita H, Yokoyama H, Higuma T, Abe N, Suzuki A, Endo T, Tateyama S, Ishida Y, Osanai T, Okumura K.
    • Journal Title

      Heart Vessels

      Volume: 28 Issue: 6 Pages: 704-713

    • DOI

      10.1007/s00380-012-0313-y

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591077
  • [Journal Article] Acute myocardial infarction cases by a floating thrombus in the ascending aorta: A role of CD34-positive endothelial cells.2013

    • Author(s)
      Nishizaki F, Tomita H, Abe N, Kimura M, Higuma T, Osanai T, Yamauchi S, Daitoku K, Fukuda I, Kamata Y, Okumura K.
    • Journal Title

      Journal of cardiology cases.

      Volume: 8 Issue: 2 Pages: e88-e90

    • DOI

      10.1016/j.jccase.2013.04.003

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591077
  • [Journal Article] Coupling factor 6-induced activation of ecto-F(1)F (o) complex induces insulin resistance, mild glucose intolerance and elevated blood pressure in mice.2012

    • Author(s)
      Osanai T, Tanaka M, Magota K, Tomita H, Okumura K.
    • Journal Title

      Diabetologia

      Volume: 55 Pages: 520-529

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591077
  • [Journal Article] Overexpression of coupling factor 6 attenuates exercise-induced physiological cardiac hypertrophy by inhibiting PI3K/Akt signaling in mice.2012

    • Author(s)
      Sagara S, Osanai T, Izumiyama K, Shibutani S, Hanada K, Yokoyama H, Yamamoto Y, Yokota T, Tomita H, Magota K, Okumura K.
    • Journal Title

      J Hypertens.

      Volume: 30 Issue: 4 Pages: 778-786

    • DOI

      10.1097/hjh.0b013e3283505101

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591077
  • [Journal Article] Br-DIF-1 accelerates dimethyl sulphoxide-induced differentiation of P19CL6 embryonic carcinoma cells into cardiomyocytes2012

    • Author(s)
      Seya K, Kanemaru K, Matsuki M, Hongo K, Kitahara H, Kikuchi H, Oshima Y, Kubohara Y, Okumura K, Motomura S, Furukawa KI
    • Journal Title

      British Journal of Pharmacology

      Volume: 165 Issue: 4 Pages: 870-879

    • DOI

      10.1111/j.1476-5381.2011.01541.x

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590090, KAKENHI-PROJECT-23591077
  • [Journal Article] Overexpression of coupling factor 6 attenuates exercise-induced physiological cardiac hypertrophy by inhibiting PI3K/Akt signaling in mice.2012

    • Author(s)
      Sagara S, Osanai T, Itoh T, Izumiyama K, Shibutani S, Hanada K, Yokoyama H, Yamamoto Y, Yokota T, Tomita H, Magota K, Okumura K.
    • Journal Title

      J Hypertens

      Volume: 30 Pages: 778-786

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24591089
  • [Journal Article]2012

    • Author(s)
      山部浩茂、奥村謙、森久健二、古山准二郎、金澤尚徳、星山禎、小川久雄
    • Journal Title

      Heart Rhythm

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590904
  • [Journal Article] Coronary Vasospasm Induced in Transgenic Mouse with the Increased Phospholipase C-δ1 Activity.2012

    • Author(s)
      Shibutani S, Osanai T, Ashitate T, Sagara S, Izumiyama K, Yamamoto Y, Hanada K, Echizen T, Tomita H, Fujita T, Miwa T, Matsubara H, Homma Y, Okumura K.
    • Journal Title

      Circulation

      Volume: 125 Pages: 1027-1036

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24591089
  • [Journal Article] Matrix metalloprotein-9 activation under cell-to-cell interaction between endothelial cells and monocytes: possible role of hypoxia and tumor necrosis factor-α.2012

    • Author(s)
      Yamamoto Y, Osanai T, Nishizaki F, Sukekawa T, Izumiyama K, Sagara S, Okumura K.
    • Journal Title

      Heart Vessels

      Volume: 27 Issue: 6 Pages: 624-633

    • DOI

      10.1007/s00380-011-0214-5

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591077
  • [Journal Article] Thrombin stimulates synthesis of macrophage colony-stimulating factor, granulocyte-macrophage colony-stimulating factor and granulocyte colony-stimulating factor by human proximal tubular epithelial cells in culture2012

    • Author(s)
      Shimaya Y, Nakamura N, et al.
    • Journal Title

      Nephron Extra

      Volume: 2 Issue: 1 Pages: 1-8

    • DOI

      10.1159/000335751

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591015, KAKENHI-PROJECT-23591077
  • [Journal Article] Estrogen attenuates coupling factor 6-induced salt-sensitive hypertension and cardiac systolic dysfunction in mice.2012

    • Author(s)
      Izumiyama K, Osanai T, Sagara S, Yamamoto Y, Itoh T, Sukekawa T, Nishizaki F, Magota K, Okumura K.
    • Journal Title

      Hypertens Res.

      Volume: 35 Issue: 5 Pages: 539-546

    • DOI

      10.1038/hr.2011.232

    • NAID

      10030645838

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591077
  • [Journal Article] Estrogen attenuates coupling factor 6-induced salt-sensitive hypertension and cardiac systolic dysfunction in mice.2012

    • Author(s)
      Izumiyama K, Osanai T, Sagara S, Yamamoto Y, Itoh T, Sukekawa T, Nishizaki F, Magota K, Okumura K.
    • Journal Title

      Hypertens Res.

      Volume: 35 Pages: 539-546

    • NAID

      10030645838

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24591089
  • [Journal Article] Coronary Vasospasm Induced in Transgenic Mouse With Increased Phospholipase C-δ1 Activity.2012

    • Author(s)
      Shibutani S, Osanai T, Ashitate T, Sagara S, Izumiyama K, Yamamoto Y, Hanada K, Echizen T, Tomita H, Fujita T, Miwa T, Matsubara H, Homma Y, Okumura K.
    • Journal Title

      Circulation.

      Volume: 28 Issue: 8 Pages: 1027-1036

    • DOI

      10.1161/circulationaha.111.064303

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591077
  • [Journal Article] Double-stranded RNA induces biphasic STAT1 phosphorylation by both type I IFN-dependent and type I IFN-independent pathways2012

    • Author(s)
      Dempoya J, Matsumiya T, Imaizumi T, Hayakari R, Xing F, Yoshida H, Okumura K, Satoh K
    • Journal Title

      J Virol

      Volume: 86(23) Issue: 23 Pages: 12760-12769

    • DOI

      10.1128/jvi.01881-12

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591259, KAKENHI-PROJECT-23590560, KAKENHI-PROJECT-23591077, KAKENHI-PROJECT-23592081
  • [Journal Article] Coupling factor 6-induced activation of ecto-F(1)F (o) complex induces insulin resistance, mild glucose intolerance and elevated blood pressure in mice.2012

    • Author(s)
      Osanai T, Tanaka M, Magota K, Tomita H, Okumura K.
    • Journal Title

      Diabetologia.

      Volume: 55 Issue: 2 Pages: 520-529

    • DOI

      10.1007/s00125-011-2341-z

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591077
  • [Journal Article] Inhibition of P38 MAP Kinase Attenuates Left Ventricular Hypertrophy and Inhibits Progression of Systolic Dysfunction on Pressure-Overload Induced Pathological Cardiac Hypertrophy in Mice.2011

    • Author(s)
      Hanada K, Osanai T, Sukekawa T, Ohya F, Izumiyama K, Sagara S, Ito T, Yamamoto Y, Sibutani S, Tomita H, Okumura K.
    • Journal Title

      Hirosaki Med J

      Volume: 62 Pages: 18-26

    • NAID

      110008425079

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591077
  • [Journal Article] Nongenomic response to aldosterone.2011

    • Author(s)
      Osanai T, Yamada M, Okumura K.
    • Journal Title

      Hypertension.

      Volume: 58

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591077
  • [Journal Article] Nongenomic response to aldosterone2011

    • Author(s)
      Osanai T, Yamada M, Okumura K
    • Journal Title

      Hypertension

      Volume: 58 Issue: 2

    • DOI

      10.1161/hypertensionaha.111.174680

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591077
  • [Journal Article] Mutation Analysis ABCC9 Gene in Japanese Patients with Coronary Spastic Angina2011

    • Author(s)
      Shibutani S, Osanai T, Oya H, Sagara S, Izumiyama K, Yamamoto Y, Hanada K, Tomita H, Okumura K
    • Journal Title

      Hirosaki Med J

      Volume: 62 Pages: 27-33

    • NAID

      110008425087

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591077
  • [Journal Article] Mutation Analysis ABCC9 Gene in Japanese Patients with Coronary Spastic Angina.2011

    • Author(s)
      Shibutani S, Osanai T, Oya H, Sagara S, Izumiyama K, Yamamoto Y, Hanada K, Tomita H, Okumura K.
    • Journal Title

      Hirosaki Med J.

      Volume: 62 Pages: 27-33

    • NAID

      110008425087

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591077
  • [Journal Article] Effects of pravastatin and rosuvastatin on the generation of adiponectin in the visceral adipose tissue in patients with coronary artery disease.2011

    • Author(s)
      Yokoyama H, Osanai T, Okumura K, et al
    • Journal Title

      Fundam Clin Pharmacol. 25

      Pages: 378-387

    • Data Source
      KAKENHI-PROJECT-20590856
  • [Journal Article] Effects of pravastatin and rosuvastatin on the generation of adiponectin in the visceral adipose tissue in patients with coronary artery disease2011

    • Author(s)
      Yokoyama H, et al
    • Journal Title

      Fundam Clin Pharmacol

      Volume: 25 Issue: 3 Pages: 378-387

    • DOI

      10.1111/j.1472-8206.2010.00847.x

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590946, KAKENHI-PROJECT-23591077
  • [Journal Article] Effects of pravastatin and rosuvastatin on the generation of adiponectin in the visceral adipose tissue in patients with coronary artery disease.2011

    • Author(s)
      Yokoyama H, Okumura K, et al.
    • Journal Title

      Fundam Clin Pharmacol

      Volume: 25 Pages: 378-387

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590856
  • [Journal Article] Inhibition of P38 MAP Kinase Attenuates Left Ventricular Hypertrophy and Inhibits Progression of Systolic Dysfunction on Pressure-Overload Induced Pathological Cardiac Hypertrophy in Mice2011

    • Author(s)
      Hanada K, Osanai T, Sukekawa T, Ohya F, Izumiyama K, Sagara S, Ito T, Yamamoto Y, Sibutani S, Tomita H, Okumura K
    • Journal Title

      Hirosaki Med J

      Volume: 62 Pages: 18-26

    • NAID

      110008425079

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591077
  • [Journal Article] Effects of pravastatin and rosuvastatin on the generation of adiponectin in the visceral adipose tissue in patients with coronary artery disease.2011

    • Author(s)
      Yokoyama H, Saito S, Daitoku K, Fukuda I, Higuma T, Hanada H, Osanai T, Okumura K.
    • Journal Title

      Fundam Clin Pharmacol.

      Volume: 25 Pages: 378-387

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591077
  • [Journal Article] Comparison of the effects of long-acting nifedipine CR and diltiazem R in patients with vasospastic angina : Aomori coronary spastic angina study.2010

    • Author(s)
      Higuma T, Okumura K, et al
    • Journal Title

      J Cardiol

      Volume: 56 Pages: 354-360

    • NAID

      10028189779

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590856
  • [Journal Article] Effects of telmisartan on markers of ventricular remodeling in patients with acute myocardial infarction : comparison with enalapril.2010

    • Author(s)
      Yokota T, Okumura K, et al
    • Journal Title

      Heart Vessels

      Volume: 25 Pages: 460-468

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590856
  • [Journal Article] Novel pro-atherogenic molecule coupling factor 6 is elevated in patients with stroke : a possible linkage to homocysteine.2010

    • Author(s)
      Osanai T, Okumura K, et al
    • Journal Title

      Ann Med. 42

      Pages: 79-86

    • Data Source
      KAKENHI-PROJECT-20590856
  • [Journal Article] Overexpression of coupling factor 6 causes cardiac dysfunction under high salt diet in mice.2010

    • Author(s)
      Ashitate T, Okumura K, et al
    • Journal Title

      J Hypertens

      Volume: 28 Pages: 2243-2251

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590856
  • [Journal Article] Novel pro-atherogenic molecule coupling factor 6 is elevated in patients with stroke : A possible linkage to homocysteine2010

    • Author(s)
      Osanai T, Fujiwara N, Sasaki S, Metoki N, Saitoh G, Tomita H, Nishimura T, Shibitani S, Yokoyama H, Konta Y, Magota K, Okumura K
    • Journal Title

      Ann Med

      Volume: 42 Pages: 79-86

    • Data Source
      KAKENHI-PROJECT-21590946
  • [Journal Article] Effects of telmisartan on markers of ventricular remodeling in patients with acute myocardial infarction : comparison with enalapril.2010

    • Author(s)
      Yokota T, Osanai T, Okumura K, et al
    • Journal Title

      Heart Vessels. 25

      Pages: 460-8

    • Data Source
      KAKENHI-PROJECT-20590856
  • [Journal Article] pl22 Protein Enhances Intracellular Calcium Increase to Acetylcholine . Its Possible Role in the Pathogenesis of Coronary Spastic Angina.2010

    • Author(s)
      Murakami R, Okumura K, et al
    • Journal Title

      Thromb Vase Biol

      Volume: 30 Pages: 1968-1975

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590856
  • [Journal Article] Brain natriuretic peptide is released from human astrocytoma cell line U373MG under hypoxia : A possible role in anti-apoptosis.2010

    • Author(s)
      Katoh C, Okumura K, et al
    • Journal Title

      J Endocrinol

      Volume: 208 Pages: 51-57

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590856
  • [Journal Article] Novel pro-atherogenic molecule coupling factor 6 is elevated in patients with stroke : A possible linkage to homocysteine.2010

    • Author(s)
      Osanai T, Fujiwara N, Sasaki S, Metoki N, Saitoh G, Tomita H, Nishimura T, Shibitani S, Yokoyama H, Konta Y, Magota K, Okumura K
    • Journal Title

      Ann Med. 42

      Pages: 79-86

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590855
  • [Journal Article] p122 Protein Enhances Intracellular Calcium Increase to Acetylcholine. Its Possible Role in the Pathogenesis of Coronary Spastic Angina.2010

    • Author(s)
      Murakami R, Osanai T, Okumura K, et al
    • Journal Title

      Arterioscler Thromb Vasc Biol. 30

      Pages: 1968-1975

    • Data Source
      KAKENHI-PROJECT-20590856
  • [Journal Article] Novel pro-atherogenic molecule-coupling factor 6 is elevated in patients with stroke : a possible linkage to homocysteine.2010

    • Author(s)
      Osanai T, Okumura K, et al
    • Journal Title

      Ann Med

      Volume: 42 Pages: 79-86

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590856
  • [Journal Article] Overexpression of coupling factor 6 causes cardiac dysfunction under high salt diet in mice2010

    • Author(s)
      Ashitate T, Osanai T, Tanaka M, Magota K, Echizen T, Izumiyama K, Yokoyama H, Shibutani S, Hanada K, Tomita H, Okumura K
    • Journal Title

      J Hypertens

      Volume: 28 Pages: 2243-2251

    • Data Source
      KAKENHI-PROJECT-21590946
  • [Journal Article] Overexpression of coupling factor 6 causes cardiac dysfunction under high salt diet in mice.2010

    • Author(s)
      Ashitate T, Osanai T, Tanaka M, Magota K, Echizen T, Izumiyama K, Yokoyama H, Shibutani S, Hanada K, Tomita H, Okumura K
    • Journal Title

      J Hypertens 28

      Pages: 2243-2251

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590855
  • [Journal Article] Effect of pilsicainide on dominant frequency in the right and left atria and pulmonary veins during atrial fibrillation : Association with its atrial fibrillation terminating effect.2009

    • Author(s)
      Horiuchi D, Okumura K, et al
    • Journal Title

      Eur J Pharmacol 608

      Pages: 54-61

    • Data Source
      KAKENHI-PROJECT-20590856
  • [Journal Article] Coupling factor 6 enhances Src-mediated responsiveness to angiotensin II in resistance arterioles and cells2009

    • Author(s)
      Osanai T, Tomita H, Kushibiki M, Yamada M, Tanaka M, Ashitate T, Echizen T, Katoh C, Magota K, Okumura K
    • Journal Title

      Cardiovasc Res

      Volume: 81 Pages: 780-787

    • Data Source
      KAKENHI-PROJECT-21590946
  • [Journal Article] Upregulation of soluble vascular endothelial growth factor receptor type 1 by endogenous prostacyclin inhibitor coupling factor 6 in vascular endothelial cells : a role of acidosis-induced c-Src activation2009

    • Author(s)
      Ken Okumura, et.al.
    • Journal Title

      Hypertens Res 32

      Pages: 182-187

    • NAID

      10024829936

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590856
  • [Journal Article] Upregulation of insulin-like growth factor-1 gene expression in cardiac myocytes by hypoxia : mechanism for its cardioprotective effect.2009

    • Author(s)
      Katoh C, Okumura K, et al
    • Journal Title

      Hirosaki Med J 60

      Pages: 36-44

    • NAID

      110007079178

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590856
  • [Journal Article] Upregulation of insulin-like growth factor-1 gene expression in cardiac myocytes by hypoxia : mechanism for its cardionrotective effect2009

    • Author(s)
      Ken Okumura, et.al.
    • Journal Title

      Hirosaki Medical Journal 60

      Pages: 36-44

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590856
  • [Journal Article] Impairment of calcium-activated potassium channels in endothelium-derived hyperpolarizing factor responses in spontaneously hypertensive rats2009

    • Author(s)
      Ken Okumura, et.al.
    • Journal Title

      Hirosaki Medical Journal 60

      Pages: 86-95

    • NAID

      110007079182

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590856
  • [Journal Article] Upregulation of soluble vascular endothelial growth factor receptor type 1 by endogenous prostacyclin inhibitor coupling factor 6 in vascular endothelial cells : a role of acidosis-induced c-Src activation.2009

    • Author(s)
      Echizen T, Osanai T, Okumura K, et al
    • Journal Title

      Hypertens Res. 32

      Pages: 182-187

    • NAID

      10024829936

    • Data Source
      KAKENHI-PROJECT-20590856
  • [Journal Article] Impact of telmisartan on coronary stenting in patients with acute myocardial infarction compared with enalapril.2009

    • Author(s)
      Yokoyama J, Osanai T, Okumura K, et al
    • Journal Title

      Int J Cardiol 132

      Pages: 114-120

    • Data Source
      KAKENHI-PROJECT-20590856
  • [Journal Article] Coupling factor 6 as a novel vasoactive and proatherogenic peptide in vascular endothelial cells.2009

    • Author(s)
      Osanai T, Okumura K, et al
    • Journal Title

      Naunyn-Schmied Arch Pharmacol 380

      Pages: 205-214

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590856
  • [Journal Article] Upregulation of soluble vascular endothelial growth factor receptor type 1 by endogenous prostacyclin inhibitor coupling factor 6 in the vascular endothelial cells : A role of acidosis-induced c-Src activation2009

    • Author(s)
      Echizen T, Osanai T, Ashitate T,Yokoyama H, Shibutani S, Tanaka M, Tomita H, Koji Magota K, Okumura K.
    • Journal Title

      Hypertens Res. 32

      Pages: 182-187

    • NAID

      10024829936

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590800
  • [Journal Article] Coupling factor 6 as a novel vasoactive and proatherogenic peptide in vascular endothelial cells.2009

    • Author(s)
      Osanai T, Magota K, Okumura K
    • Journal Title

      Naunyn-Schmied Arch Pharmacol 380

      Pages: 205-214

    • Data Source
      KAKENHI-PROJECT-20590856
  • [Journal Article] Effect of pilsicaihide on dominant frequency in the right and left atria and pulmonary veins during atrial fibrillation : Association with its atrial fibrillation terminating effect2009

    • Author(s)
      Ken Okumura, et.al.
    • Journal Title

      Eur J Pharmacol 608

      Pages: 54-61

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590856
  • [Journal Article] Impairment of calcium-activated potassium channels in endothelium-derived hyperpolarizing factor responses in spontaneously hypertensive rats.2009

    • Author(s)
      Hasegawa K, Okumura K, et al
    • Journal Title

      Hirosaki Med J 60

      Pages: 86-95

    • NAID

      110007079182

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590856
  • [Journal Article] Generation and characterization of coupling factor 6-oberexpressing transgenic mice.2009

    • Author(s)
      Ashitate T, Okumura K, et al
    • Journal Title

      Hirosaki Med J 60

      Pages: 18-26

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590856
  • [Journal Article] Coupling factor 6 enhances Src-mediated responsiveness to angiotensin II in resistance arterioles and cells.2009

    • Author(s)
      Osanai T, Tomita H, Kushibiki M, Yamada M, Tanaka M, Ashitate T, Echizen T, Katoh C, Magota K, Okumura K
    • Journal Title

      Cardiovasc Res. 81

      Pages: 780-787

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590855
  • [Journal Article] Coupling factor 6 as a novel vasoactive and proatherogenic peptide in vascular endothelial cells2009

    • Author(s)
      Osanai T, Magota K, Okumura K
    • Journal Title

      Naunyn Schmiedebergs Arch Pharmacol

      Volume: 380 Pages: 205-214

    • Data Source
      KAKENHI-PROJECT-21590946
  • [Journal Article] Upregulation of soluble vascular endothelial growth factor receptor type 1 by endogenous prostacyclin inhibitor coupling factor 6 in vascular endothelial cells : a role of acidosis-induced c-Src activation.2009

    • Author(s)
      Echizen T, Okumura K, et al
    • Journal Title

      Hypertens Res. 32

      Pages: 182-187

    • NAID

      10024829936

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590856
  • [Journal Article] From 4-links to 5-links of "Chain of survival"--Post-resus citation care is critical for good neurological recovery--2009

    • Author(s)
      Hanada H, Okumura K, et al
    • Journal Title

      Circ J 73

      Pages: 1797-1798

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590856
  • [Journal Article] Generation and characterization of coupling factor 6-overexpressing transgenic mice2009

    • Author(s)
      Asitate T, Osanai T, Tanaka M, Magota K, Echizen T, Tomita T, Okumura K
    • Journal Title

      Hirosaki Medical Journal 60

      Pages: 18-26

    • NAID

      110007079176

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590800
  • [Journal Article] Coupling factor 6 as a novel vasoactive and proatherogenic peptide in vascular endothelial cells.2009

    • Author(s)
      Osanai T, Magota K, Okumura K
    • Journal Title

      Naunyn Schmiedebergs Arch Pharmacol. 380

      Pages: 205-214

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590855
  • [Journal Article] Coupling factor 6 enhances Src-mediated responsiveness to angiotensin II in resistance arterioles and cells.2009

    • Author(s)
      Osanai T, Okumura K, et al
    • Journal Title

      Cardiovasc Res 81

      Pages: 780-787

    • Data Source
      KAKENHI-PROJECT-20590856
  • [Journal Article] Impact of telmisartan on coronary stenting in patients with acute myocardial infarction compared with enalapril.2009

    • Author(s)
      Yokoyama J, Okumura K, et al
    • Journal Title

      Int J Cardiol 132

      Pages: 114-120

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590856
  • [Journal Article] Generation and characterization of coupling factor 6-overexpressing transgenic mice2009

    • Author(s)
      Ken Okumura, et.al.
    • Journal Title

      Hirosaki Medical Journal 60

      Pages: 18-26

    • NAID

      110007079176

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590856
  • [Journal Article] Coupling factor 6-induced prostacyclin inhibition is enhanced in vascular smooth muscle cells from spontaneously hypertensive rats2009

    • Author(s)
      Osanai T, Tomita H, Yamada M, Tanaka M, Ashidate T, Echizen T, Katoh C, Magota K, Okumura K
    • Journal Title

      J Hypertens

      Volume: 27 Pages: 1823-1828

    • Data Source
      KAKENHI-PROJECT-21590946
  • [Journal Article] Upregulation of soluble vascular endothelial growth factor receptor type 1 by endogenous prostacyclin inhibitor coupling factor 6 in the vascular endothelial cells : A role of acidosis-induced c-Src activation.2009

    • Author(s)
      Echizen T, Osanai T, Ashitate T, Yokoyama H, Shibutani S, Tanaka M, Tomita H, Koji Magota K, Okumura K
    • Journal Title

      Hypertens Res 32

      Pages: 182-187

    • NAID

      10024829936

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590855
  • [Journal Article] Coupling factor 6-induced prostacyclin inhibition is enhanced in vascular smooth muscle cells from spontaneously hypertensive rats.2009

    • Author(s)
      Osanai T, Tomita H, Yamada M, Tanaka M, Ashidate T, Echizen T, Katoh C, Magota K, Okumura K
    • Journal Title

      J Hypertens 27

      Pages: 1823-1828

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590855
  • [Journal Article] Generation and characterization of coupling factor 6-overexpressing transgenic mice.2009

    • Author(s)
      Asitate T, Osanai T, Tanaka M, Magota K, Echizen T, Tomita T, Okumura K
    • Journal Title

      Hirosaki Medical Journal 60

      Pages: 18-26

    • NAID

      110007079176

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590855
  • [Journal Article] Coupling factor 6 enhances Src-mediated responsiveness to angiotensin II in resistance arterioles and cells2009

    • Author(s)
      Osanai T, Tomita H, Kushibiki M, Yamada M, Tanaka M, Ashitate T, Echizen T, Katoh C, Magota K, Okumura K.
    • Journal Title

      Cardiovasc Res. 81

      Pages: 780-787

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590800
  • [Journal Article] Coupling factor 6 enhances Src-mediated responsiveness to angiotensin II in resistance arterioles and cells2009

    • Author(s)
      Ken Okumura, et.al.
    • Journal Title

      Cardiovasc Res 81

      Pages: 780-787

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590856
  • [Journal Article] Amiodarone Attenuates the Upregulated Matrix Metalloproteinase-2 Activity in a Rat Myocardial Infarction Model.2009

    • Author(s)
      Horiuchi D, Okumura K, et al
    • Journal Title

      Hirosaki Med J 60

      Pages: 45-53

    • NAID

      110007079179

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590856
  • [Journal Article] Vasoconstrictor effect of aldosterone via angiotensin II type 1(AT_1)receptor: Arole of AT_1 receptor dimerization2008

    • Author(s)
      Ken Okumura, et. al.
    • Journal Title

      Cardiovasc Res 77(in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18590758
  • [Journal Article] Decreased plasma and cardiac matrix metalloproteinase activities in patients with coronary artery disease and treated with pravastatin2008

    • Author(s)
      Ken Okumura, et.al.
    • Journal Title

      European J Pharmacol 594

      Pages: 146-151

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590856
  • [Journal Article] Coupling factor 6 downregulates platelet endothelial cell adhesion molecule-1 via c-Src activation and acts as a proatherogenic molecule2008

    • Author(s)
      Kumagai A, Osanai T, Katoh C, Tanaka M, Tomita H, Morimoto T, Murakami R, Magota K, Okumura K.
    • Journal Title

      Atherosclerosis (In press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18590758
  • [Journal Article] Increased Adiponectin synthesis in the visceral adipose tissue in men with coronary artery disease treated with pravastatin : A role of the attenuation of oxidative stress2008

    • Author(s)
      Ken Okumura, et.al.
    • Journal Title

      Atherosclerosis 199

      Pages: 378-383

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590856
  • [Journal Article] Increased Adiponectin synthesis in the visceral adipose tissue in men with coronary artery disease treated with pravastatin: A role of the attenuation of oxidative stress.2008

    • Author(s)
      Ken Okumura, et. al.
    • Journal Title

      Atherosclerosis 199(In press)

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18590758
  • [Journal Article] Increased Adiponectin synthesis in the visceral adipose tissue in men with coronary artery disease treated with pravastatin: A role of the attenuation of oxidative stress2008

    • Author(s)
      Saito S, Fujiwara T, Matsunaga T, Minagawa K, Fukui K, Fukuda I, Osanai T, Okumura K.
    • Journal Title

      Atherosclerosis (In press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18590758
  • [Journal Article] Coupling factor 6 downregulates platelet endothelial cell adhesion molecule-1 via c-Src activation and acts as a proatherogenic molecule2008

    • Author(s)
      Kumagai A, Osanai T, Katoh C, Tanaka M,Tomita H, Morimoto T, Murakami R, Magota K, Okumura K
    • Journal Title

      Atherosclerosis 200

      Pages: 45-50

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590800
  • [Journal Article] Vasoconstrictor effect of aldosterone via angiotensin II type 1(AT_1) receptor : possible role of AT_1 receptor dimerization2008

    • Author(s)
      Ken Okumura, et.al.
    • Journal Title

      Cardiovasc Res 79

      Pages: 169-178

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590856
  • [Journal Article] Coupling factor 6 downregulates platelet endothelial cell adhesion molecule-1 via c-Src activation and acts as a proatherogenic molecule2008

    • Author(s)
      Ken Okumura, et.al.
    • Journal Title

      Atherosclerosis 200

      Pages: 45-50

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590856
  • [Journal Article] Vasoconstrictor effect of aldosterone via angiotensin II type 1 (AT_1) receptor: A role of AT_1 receptor dimerization2008

    • Author(s)
      Ken Okamura, et. al.
    • Journal Title

      Cardiovasc Res 77(in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18590758
  • [Journal Article] Coupling factor 6 downregulates platelet endothelial cell adhesion molecule-l via c-Src activation and as a proatherogenic molecule.2008

    • Author(s)
      Ken Okamura, et. al.
    • Journal Title

      Atherosclerosis 199(In press)

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18590758
  • [Journal Article] Elevated plasma, brain natriuretic peptide levels independent of heart disease in acute ischemic stroke : Correlation with stroke severity2008

    • Author(s)
      Ken Okumura, et.al.
    • Journal Title

      Hypertens Res 31

      Pages: 1695-1702

    • NAID

      10024362177

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590856
  • [Journal Article] Vasoconstrictor effect of aldosterone via angiotensin II type 1 (AT1) receptor: Possible role of AT1 receptor dimerization2008

    • Author(s)
      Yamada M, Kushibiki M, Osanai T, Tomita H, Okumura K.
    • Journal Title

      Cardiovasc Res (In press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18590758
  • [Journal Article] Coupling factor 6 downregulates platelet endothelial cell adhesion molecule-1 via c-Src activation and acts as a proatherogenic molecule.2008

    • Author(s)
      Kumagai A, Osanai T, Katoh C, Tanaka M, Tomita H, Morimoto T, Murakami R, Magota K, Okumura K
    • Journal Title

      Atherosclerosis. 200

      Pages: 45-50

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590855
  • [Journal Article] Fatty Acid Composition of Plasma and Kidney in Rats with Anti-Thy1.1 Nephritis.2007

    • Author(s)
      Ken Okumura, et. al.
    • Journal Title

      In vivo 21

      Pages: 77-80

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18590758
  • [Journal Article] Electrocardiogram reading by step2007

    • Author(s)
      Okumura K.
    • Journal Title

      Nankodo, Tokyo 206

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18590758
  • [Journal Article] Aldosterone cause vasoconstriction in coronary arterioles of rats via angiotensin II type-1 receptor: Influence of hypertension2007

    • Author(s)
      Kushibiki M, Yamada M, Oikawa K, Tomita H, Osanai T, Okumura K.
    • Journal Title

      Eur J Pharmacol 572

      Pages: 182-188

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18590758
  • [Journal Article] Aldosterone causes vasoconstriction in coronary arterioles of rats viaangiotensin II type-1 receptor: Influence of hypertension2007

    • Author(s)
      Ken Okumura, et. al.
    • Journal Title

      Eur J Pharmacol 572

      Pages: 182-188

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18590758
  • [Journal Article] Fatty Acid Composition of Plasma and Kidney in Rats with Anti-Thy1.1 Nephritis2007

    • Author(s)
      Kumasaka R, Nakamura N, Yamabe H, Osawa H, Shirato K, Shimada M, Murakami R, Fujita T, Okumura K, Hamazaki K, Hamazaki T.
    • Journal Title

      In vivo 21

      Pages: 77-80

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18590758
  • [Journal Article] Therapeutic challenge to adiposity of the heart2007

    • Author(s)
      Ken Okumura, et. al.
    • Journal Title

      Circ Res 100

      Pages: 1106-1108

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18590758
  • [Journal Article] Therapeutic challenge to adiposity of the heart2007

    • Author(s)
      Osanai T, Okumura K.
    • Journal Title

      Circ Res 100

      Pages: 1106-1108

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18590758
  • [Journal Article] Extracellular matrix remodeling as a cause of persistent atrial fibrillation: Another therapeutic target2007

    • Author(s)
      Okumura K.
    • Journal Title

      J Cardiovasc Electrophysiol 18

      Pages: 1083-1085

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18590758
  • [Journal Article] Hypoxic conditions stimulate the production of angiogenin and vascular endothelial growth factor by human renal proximal tubular epithelial cells in culture.2006

    • Author(s)
      Ken Okumura, et al.
    • Journal Title

      Nephrology Dialysis Transplantation 21・6

      Pages: 1489-1495

    • Data Source
      KAKENHI-PROJECT-18590758
  • [Journal Article] Effects of amiodarone on electrical and structural remodeling induced in a canine rapid pacing-induced persistent atrial fibrillation model.2006

    • Author(s)
      Ken Okumura, et al.
    • Journal Title

      European Journal of Pharmacology 536・1

      Pages: 148-153

    • Data Source
      KAKENHI-PROJECT-18590758
  • [Journal Article] Effect of vasoconstrictor coupling factor 6 on gene expression profile in human vascular endothelial cells : enhanced release of asymmetric dimethylarginine.2006

    • Author(s)
      Ken Okumura, et al.
    • Journal Title

      Journal of Hypertension 24・3

      Pages: 489-497

    • Data Source
      KAKENHI-PROJECT-18590758
  • [Journal Article] Mutational analysis of Kir6.1 in Japanese patients with coronary spastic angina.2006

    • Author(s)
      Ken Okumura, et al.
    • Journal Title

      International Journal of Molecular Medicine 18・4

      Pages: 589-591

    • Data Source
      KAKENHI-PROJECT-18590758
  • [Journal Article] Increased level of pericardial insulin-like growth factor-1 in patients with left ventricular dysfunction and advanced heart failure.2006

    • Author(s)
      Ken Okumura, et al.
    • Journal Title

      Journal of the American College of Cardiology 48・7

      Pages: 1387-1395

    • Data Source
      KAKENHI-PROJECT-18590758
  • [Journal Article] Increased pericardial fluid level of matrix metalloproteinase-9 activity in patients with acute myocardial Infarction : possible role in the development of cardia rupture.2006

    • Author(s)
      Ken Okumura, et al.
    • Journal Title

      Circulation Journal 70・6

      Pages: 673-678

    • Data Source
      KAKENHI-PROJECT-18590758
  • [Journal Article] Nocturnal blood pressure decrease is associated with increased regional cerebral blood flow in patients with a history of ischemic stroke.2005

    • Author(s)
      Fujiwara N, Okumura K, et al.
    • Journal Title

      J Hyperten 23

      Pages: 1055-1060

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15590712
  • [Journal Article] Tumor necrosis factor a as an endogenous stimulator for circulating coupling factor 6.2004

    • Author(s)
      Sasaki S, Okumura K, et al.
    • Journal Title

      Cardiovasc Res 62

      Pages: 578-586

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15590712
  • [Journal Article] Tumor necrosis factor a as an endogenous stimulator for circulating coupling factor 6.2004

    • Author(s)
      Sasaki S, Okumura K, et al.
    • Journal Title

      Cardiovasc Res 62・3

      Pages: 578-586

    • Data Source
      KAKENHI-PROJECT-15590712
  • [Journal Article] Nicorandil improves cardiac function and clinical outcome in patients with acute myocardial infarction undergoing primary percutaneous coronary intervention : Role of inhibitory effect on reactive oxygen species formation.2004

    • Author(s)
      Ono H, Okumura K, et al.
    • Journal Title

      Am Heart J 148

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15590712
  • [Journal Article] Effect of shear stress on asymmetric dimethylarginine release from vascular endothelial cells.2003

    • Author(s)
      Osanai T, Okumura K, et al.
    • Journal Title

      Hypertension 42

      Pages: 985-990

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15590712
  • [Journal Article] Plasma concentration of coupling factor 6 and cardiovascular events in patients with end-stage renal disease.2003

    • Author(s)
      Osanai T, Okumura K, et al.
    • Journal Title

      Kidney International 64・6

      Pages: 2291-2297

    • Data Source
      KAKENHI-PROJECT-15590712
  • [Journal Article] Effect of allopurinol pretreatment on free radical generation after primary coronary angioplasty for acute myocardial infarction.2003

    • Author(s)
      Guan W, Okumura K, et al.
    • Journal Title

      J Cardiovasc Pharmacol 41

      Pages: 699-705

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15590712
  • [Journal Article] High plasma level of asymmetric dimethylarginine in patients with acutely exacerbated congestive heart failure : role in reduction of plasma nitric oxide level.2003

    • Author(s)
      Saitoh M, Okumura K, et al.
    • Journal Title

      Heart Vessels 18

      Pages: 177-182

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15590712
  • [Journal Article] Plasma concentration of coupling factor 6 and cardiovascular events in patients with end-stage renal disease.2003

    • Author(s)
      Osanai T, Okumura K, et al.
    • Journal Title

      Kidney International 64

      Pages: 2291-2297

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15590712
  • [Journal Article] Comparison of the effects of losartan and angiotensin converting enzyme inhibitor on nocturnal blood pressure in patients with stroke.2003

    • Author(s)
      Fujiwara N, Okumura K, et al.
    • Journal Title

      International Congress Series 1251

      Pages: 111-117

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15590712
  • [Journal Article] Effect of shear stress on asymmetric dimethylarginine release from vascular endothelial cells.2003

    • Author(s)
      Osanai T, Okumura K, et al.
    • Journal Title

      Hypertension 42・5

      Pages: 985-990

    • Data Source
      KAKENHI-PROJECT-15590712
  • [Journal Article] Circulating coupling factor 6 in human hypertension : role of reactive oxcygen species.2003

    • Author(s)
      Osanai T, Okumura K, et al.
    • Journal Title

      J Hypertens 21

      Pages: 2323-2328

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15590712
  • [Journal Article] Phospholipase C activity is enhanced in skin fibroblasts obtained from patients with essential hypertension.2003

    • Author(s)
      Kosugi T, Okumura K, et al.
    • Journal Title

      J Hypertens 21

      Pages: 583-590

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15590712
  • [Journal Article] Correlation of oxidative stress with activity of matrix metalloproteinase in patients with coronary artery disease.2003

    • Author(s)
      Kameda K, Okumura K, et al.
    • Journal Title

      Eur Heart J 24

      Pages: 2180-2185

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15590712
  • [Journal Article] Correlation of oxidative stress with activity of matrix metalloproteinase in patients with coronary artery disease.2003

    • Author(s)
      Kameda K, Okumura K, et al.
    • Journal Title

      Eur Heart J 24・24

      Pages: 2180-2185

    • Data Source
      KAKENHI-PROJECT-15590712
  • [Journal Article] Enhanced activity of variant phospholipase C δ1 protein (R257H) detected in patients with coronary artery spasm.2002

    • Author(s)
      Nakano T, Okumura K, et al.
    • Journal Title

      Circulation 105

      Pages: 2024-2029

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15590712
  • [Journal Article] Enhanced activity of variant phospholipase C δ1 protein (R257H) detected in patients with coronary artery spasm.2002

    • Author(s)
      Nakano T, Okumura K, et al.
    • Journal Title

      Circulation 105・17

      Pages: 2024-2029

    • Data Source
      KAKENHI-PROJECT-15590712
  • [Journal Article] Effect of losartan on nocturnal blood pressure in patients with stroke : comparison with angiotensin converting enzyme inhibitor.2002

    • Author(s)
      Okuguchi T, Okumura K, et al.
    • Journal Title

      Am J Hyperten 15

      Pages: 998-1002

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15590712
  • [Journal Article] Mitochondorial coupling factor 6 as an endogenous inhibitor of prostacyclin synthesis and an endogenous vasoconstrictor.2002

    • Author(s)
      Osanai T, Okumura K, et al.
    • Journal Title

      International Congress Series 1244

      Pages: 131-141

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15590712
  • [Journal Article] Relationship between salt intake, Nitric Oxide and Asymmetric Dimethylarginine and its relevance to patients with end-stage renal disease.2002

    • Author(s)
      Osanai T, Okumura K, et al.
    • Journal Title

      Blood Purif 20

      Pages: 466-468

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15590712
  • [Journal Article] Cross talk between prostacyclin and nitric oxide under shear in smooth muscle cell. Role in monocyte adhesion.2001

    • Author(s)
      Osanai T, Okumura K, et al.
    • Journal Title

      Am J Physiol 281

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15590712
  • [Journal Article] Intramyocardial delivery of basic fibroblast growth factor-impregnated gelatin hydrogel microspheres enhances collateral circulation to infracted canine myocardium.2001

    • Author(s)
      Yamamoto T, Okumura K, et al.
    • Journal Title

      Jpn Circ J 65

      Pages: 439-444

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15590712
  • [Journal Article] Nitric oxide donor FK409 and 8-bromoguanosine-cyclic monophosphate attenuate cardiac contractility assessed by Emax.2001

    • Author(s)
      Hiraga H, Okumura K, et al.
    • Journal Title

      Fundam Clin Pharmacol 15

      Pages: 125-134

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15590712
  • [Journal Article] Mitochondrial coupling factor 6 as a potent endogenous vasoconstrictor.2001

    • Author(s)
      Osanai T, Okumura K, et al.
    • Journal Title

      J Clin Invest 108

      Pages: 1023-1030

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15590712
  • [Journal Article] Plasma levels of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 are increased in the coronary circulation in patients with acute coronary syndrome.2001

    • Author(s)
      Inokubo Y, Okumura K, et al.
    • Journal Title

      Am Heart J 141

      Pages: 211-217

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15590712
  • [Journal Article] Enhanced Phospholipase C Activity in the Cultured Skin Fibroblast Obtained From Patients With Coronary Spastic Angina : Possible Role for Enhanced Vasoconstrictor Response.2000

    • Author(s)
      Okumura K, et al.
    • Journal Title

      J Am Coll Cardiol 36

      Pages: 1847-1582

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15590712
  • [Journal Article] Enhanced Phospholipase C Activity in the Cultured Skin Fibroblast Obtained From Patients With Coronary Spastic Angina : Possible Role for Enhanced Vasoconstrictor Response.2000

    • Author(s)
      Okumura K, et al.
    • Journal Title

      J Am Coll Cardiol 36・6

      Pages: 1847-1852

    • Data Source
      KAKENHI-PROJECT-15590712
  • [Journal Article] Enhanced Phospholipase C Activity in the Cultured Skin Fibroblast Obtained From Patients With Coronary Spastic Angina : Possible Role for Enhanced Vasoconstrictor Response.2000

    • Author(s)
      Okumura K, et al.
    • Journal Title

      J Am Con Cardiol 36

      Pages: 1847-1852

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590712
  • [Presentation] p122RhoGAP/DLC-1 Overexpression Enhances Intracellular Calcium Concentration and Causes Coronary Spasm: Potential Role for Coronary Spastic Angina.2019

    • Author(s)
      工藤奈津美, 木村嘉宏, 花田賢二, 加藤朋, 對馬迪子, 外山佑一, 横野良和, 妹尾麻衣子, 成田憲紀, 成田真人, 米倉学, 市川博章, 長内智宏, 奥村謙, 富田泰史
    • Organizer
      第83回日本循環器学会学術集会
    • Data Source
      KAKENHI-PROJECT-16K09489
  • [Presentation] β-Arrestin 1 Negatively Regulates Intracellular Calcium Concentration in Acetylcholine M3 Receptor: Its Possible Role in Coronary Spastic Angina.2019

    • Author(s)
      妹尾麻衣子, 花田賢二, 成田真人, 成田憲紀, 加藤朋, 工藤奈津美, 横野良和, 野坂匡史, 奥村謙, 長内智宏, 富田泰史
    • Organizer
      第83回日本循環器学会学術集会
    • Data Source
      KAKENHI-PROJECT-16K09489
  • [Presentation] Rivaroxaban ameliorates hypertensive renal damage through inhibition of protease-activated receptor pathways in mice overexpressing renin2018

    • Author(s)
      市川博章、成田真人、横野良和、加藤朋、木村嘉宏、妹尾麻衣子、成田憲紀、工藤奈津美、田中真実、長内智宏、奥村謙、富田泰史.
    • Organizer
      第82日本循環器学会学術集会
    • Data Source
      KAKENHI-PROJECT-16K09489
  • [Presentation] Experimental Study for Elucidating Mechanism of Coronary Spasm Using iPSC; Role of p122 RhoGAP/DLC-1 and Phospholipase C.2018

    • Author(s)
      田中真実, 長内智宏, 奥村謙, 富田泰史.
    • Organizer
      第82日本循環器学会学術集会
    • Data Source
      KAKENHI-PROJECT-16K09489
  • [Presentation] A direct factor Xa inhibitor, rivaroxaban, attenuates cardiac hypertrophy and fibrosis in renin-overexpressing hypertensive mice.2018

    • Author(s)
      Narita M, Hanada K, Yokono Y, Narita N, Senoo M, Kimura Y, Ichikawa H, Shimada M, Tanaka M, Osanai T, Okumura K, Tomita H.
    • Organizer
      European Society of Cardiology Congress 2018
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K09489
  • [Presentation] p122RhoGAP/DLC-1 Overexpression Enhances Intracellular Calcium Concentration in Response to Acetylcholine in Isolated Vascular Smooth Muscle Cells.2018

    • Author(s)
      Kimura Y, Hanada K, Senoo M, Narita N, Narita M, Yonekura M, Ichikawa H, Tanaka M, Osanai T, Okumura K, Tomita H.
    • Organizer
      第82日本循環器学会学術集会
    • Data Source
      KAKENHI-PROJECT-16K09489
  • [Presentation] Involvement of Beta-arrestin-mediated Signaling in Acetylcholine M3 Receptor: Its Possible Role in Coronary Spastic Angina.2018

    • Author(s)
      Senoo M, Hanada K, Ichikawa H, Kimura Y, Narita M, Narita N, Kato T, Kudo N, YokonoY, Tanaka M, Osanai T, Okumura K, Tomita H.
    • Organizer
      第82日本循環器学会学術集会
    • Data Source
      KAKENHI-PROJECT-16K09489
  • [Presentation] p122RhoGAP/DLC-1 Overexpression Enhances Intracellular Calcium Concentration and Causes Coronary Spasm: Potential Role for Coronary Spastic Angina.2018

    • Author(s)
      Kudo N, Kimura Y, Hanada K, Kato T, Tsushima M, Toyama Y, Yokono Y, Senoo M, Narita N, Narita M, Yonekura M, Ichikawa H, Tanaka M, Osanai T, Okumura K, Tomita H.
    • Organizer
      American Heart Association Scientific Sessions 2019
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K09489
  • [Presentation] Inhibitory Effects of Rivaroxaban, a Direct Factor Xa Inhibitor, on Cardiac Hypertrophy and Fibrosis in Renin-Overexpressing Hypertensive Mice.2018

    • Author(s)
      Narita M, Hanada K, Yokono Y, Senoo M, Narita N, Kudo N, Kato T, Nozaka M, Kawamura Y, Tanaka M, Shimada M, Osanai T, Okumura K, Tomita H.
    • Organizer
      American Heart Association Scientific Sessions 2019
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K09489
  • [Presentation] Carvedilol Suppresses Coronary Spasm in A-Kinase Anchoring Protein 150 Knockout Mice: Its Novel Therapeutic Role in Coronary Spastic Angina.2018

    • Author(s)
      Narita N, Hanada K, Kawamura Y, Nozaka M, Kato T, Kudo N, Yokono Y, Senoo M, Narita M, Tanaka M, Osanai T, Okumura K, Tomita H.
    • Organizer
      American Heart Association Scientific Sessions 2019
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K09489
  • [Presentation] Disruption of A-kinase anchoring protein 150 causes coronary spasm through enhanced calcium sensitization: a potential role of microRNA-30b2017

    • Author(s)
      Nishzaki K, Tomita H, Senoo M, Narita N, Narita M, Yonekura M, Ichikawa H, Kimura Y, Tanaka M, Osanai T, Okumura K.
    • Organizer
      AHA Scientific Session 2016
    • Place of Presentation
      ニューオリンズ(米国)
    • Year and Date
      2017-11-12
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K09489
  • [Presentation] p122RhoGAP/DLC-1 Overexpression Enhances Intracellular Calcium Concentration in Response to Acetylcholine in Isolated Vascular Smooth Muscle Cells2017

    • Author(s)
      Kimura Y, Hanada K, Senoo M, Narita N, Narita M, Yonekura M, Ichikawa H, Tanaka M, Okumura K, Tomita H.
    • Organizer
      American Heart Association (AHA) Scientific Sessions 2017
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K09489
  • [Presentation] 第Xa因子阻害薬リバーロキサバンの高血圧性腎障害保護作用の検討2017

    • Author(s)
      市川博章、島田美智子、成田真人、木村嘉宏、妹尾麻衣子、成田憲紀、米倉学、田中真実、長内智宏、奥村謙、富田泰史.
    • Organizer
      第40回日本高血圧学会総会
    • Data Source
      KAKENHI-PROJECT-16K09489
  • [Presentation] A Direct Factor Xa Inhibitor, Rivaroxaban, Attenuates Cardiac Hypertrophy and Fibrosis in Renin-overexpressing Hypertensive Mice.2017

    • Author(s)
      Narita M, Ichikawa H, Kimura Y, Senoo M, Yonekura M, Narita N, Hanada K, Shimada M, Tanaka M, Osanai T, Okumura K, Tomita H.
    • Organizer
      American Heart Association (AHA) Scientific Sessions 2017
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K09489
  • [Presentation] p122RhoGAP/DLC-1 Overexpression Enhances Intracellular Calcium Concentration in Response to Acetylcholine in Isolated Vascular Smooth Muscle Cells2017

    • Author(s)
      Kimura Y, Tomita H, Okumura K,et al.
    • Organizer
      第81回日本循環器学会学術集会
    • Place of Presentation
      金沢フォーラス(石川県・金沢市)
    • Data Source
      KAKENHI-PROJECT-26461120
  • [Presentation] Trend of Anticoagulation Therapy in Patients with Non-valvular Atrial Fibrillation in a Japanese Local Region: Analysis Using the “Kokuho Database”2017

    • Author(s)
      成田 憲紀、富田 泰史、奥村 謙
    • Organizer
      第81回日本循環器学会学術集会
    • Place of Presentation
      ANA クラウンプラザホテル金沢(石川県・金沢市)
    • Data Source
      KAKENHI-PROJECT-26461120
  • [Presentation] A Direct Factor Xa Inhibitor, Rivaroxaban, Attenuates Cardiac Hypertrophy and Fibrosis in Renin-overexpressing Hypertensive Mice.2017

    • Author(s)
      成田真人、市川博章、木村嘉宏、妹尾麻衣子、米倉学、成田憲紀、花田賢二、島田美智子、田中真実、長内智宏、奥村謙、富田泰史.
    • Organizer
      第40回日本高血圧学会総会
    • Data Source
      KAKENHI-PROJECT-16K09489
  • [Presentation] Rivaroxaban ameliorates hypertensive renal damage through inhibition of protease-activated receptor pathways in mice overexpressing renin2017

    • Author(s)
      Ichikawa H, Tomita H, Narita M, Nishizaki K, Kimura Y, Senoo M, Narita N, Yonekura M, Tanaka M, Osanai T, Okumura K.
    • Organizer
      第81回日本循環器学会学術集会
    • Place of Presentation
      石川県立音楽堂(石川県、金沢市)
    • Year and Date
      2017-03-17
    • Data Source
      KAKENHI-PROJECT-16K09489
  • [Presentation] Possible Involvement of Epidermal Growth Factor Receptor Transactivation in Acetylcholine Muscarinic M3 Receptor Signaling in Coronary Spasm2017

    • Author(s)
      Senoo M, Hanada K, Okumura K, et al.
    • Organizer
      第81回日本循環器学会学術集会
    • Place of Presentation
      金沢市教育プラザ(石川県・金沢市)
    • Data Source
      KAKENHI-PROJECT-26461120
  • [Presentation] Possible involvement of epidermal growth factor receptor transactivation in acetylcholine muscarinic M3 receptor signaling in coronary spasm2017

    • Author(s)
      Senoo M, Hanada K, Nishizaki K, Ichikawa H, Kimura Y, Narita N, Narita M, Yonekura M, Tanaka M, Osanai T, Okumura K, Tomita H.
    • Organizer
      第81回日本循環器学会学術集会
    • Place of Presentation
      石川県立音楽堂(石川県、金沢市)
    • Year and Date
      2017-03-17
    • Data Source
      KAKENHI-PROJECT-16K09489
  • [Presentation] Rivaroxaban, a direct factor Xa inhibitor, ameliorates angiotensin II-induced renal damage through inhibition of protease-activated receptor pathway-mediated inflammatory response.2017

    • Author(s)
      Ichikawa H, Shimada M, Narita M, Kimura Y, Senoo M, Narita N, Yonekura M, Tanaka M, Osanai T, Okumura K, Tomita H.
    • Organizer
      American Heart Association (AHA) Scientific Sessions 2017
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K09489
  • [Presentation] A direct factor Xa inhibitor, rivaroxaban, attenuates cardiac hypertrophy and fibrosis in renin-overexpressing hypertensive mice2017

    • Author(s)
      Narita M, Tomita H, Okumura K.
    • Organizer
      第81回日本循環器学会学術集会
    • Place of Presentation
      石川県立音楽堂(石川県、金沢市)
    • Year and Date
      2017-03-17
    • Data Source
      KAKENHI-PROJECT-16K09489
  • [Presentation] Carvedilol suppresses ST segment elevation in A-kinase anchoring protein 150 knockout mice: its novel therapeutic role in coronary spastic angina.2017

    • Author(s)
      Narita N, Hanada K, Ichikawa H, Kimura Y, Senoo M, Narita M, Yonekura M, Tanaka M, Osanai T, Okumura K, Tomita H.
    • Organizer
      American Heart Association (AHA) Scientific Sessions 2017
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K09489
  • [Presentation] Experimental Study for Elucidating Mechanism of Coronary Spasm Using Ipsc-derived Smooth Muscle Cells; Role of P122 Rhogap / Dlc-1 and Phospholipase C2017

    • Author(s)
      Tanaka M, Osanai T, Okumura K, Tomita H.
    • Organizer
      American Heart Association (AHA) Scientific Sessions 2017
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K09489
  • [Presentation] Disruption of A-kinase anchoring protein 150 induces coronary spasm through enhancement of calcium sensitization: a potential role of microRNA-30b2017

    • Author(s)
      Nishzaki K, Narita N, Senoo M, Narita M, Yonekura M, Kimura Y, Ichikawa H, Tanaka M, Osanai T, Okumura K.
    • Organizer
      第81回日本循環器学会学術集会
    • Place of Presentation
      石川県立音楽堂(石川県、金沢市)
    • Year and Date
      2017-03-17
    • Data Source
      KAKENHI-PROJECT-16K09489
  • [Presentation] p122RhoGAP/DLC-1 overexpression enhances intracellular calcium concentration in response to acetylcholine in isolated vascular smooth muscle cells2017

    • Author(s)
      Kimura Y, Tomita H, Hanada K, Senoo M, Narita N, Narita M, Yonekura M, Ichikawa H, Nishizaki K, Tanaka M, Osanai T, Okumura K.
    • Organizer
      第81回日本循環器学会学術集会
    • Place of Presentation
      石川県立音楽堂(石川県、金沢市)
    • Year and Date
      2017-03-17
    • Data Source
      KAKENHI-PROJECT-16K09489
  • [Presentation] Disruption of A-kinase Anchoring Protein 150 Induces Coronary Spasm through Enhancement of Calcium Sensitization: A Potential Role of microRNA-30b2017

    • Author(s)
      Nishizaki K, Tomita H, Okumura K, et al.
    • Organizer
      第81回日本循環器学会学術集会
    • Place of Presentation
      金沢フォーラス(石川県・金沢市)
    • Data Source
      KAKENHI-PROJECT-26461120
  • [Presentation] Disruption of A-kinase Anchoring Protein 150 Causes Coronary Spasm Through Enhanced Calcium Sensitization: A Potential Role of Microrna-30b2016

    • Author(s)
      Nishizaki K, Tomita H, Okumura K, et al.
    • Organizer
      AHA2016
    • Place of Presentation
      New Orleans, LA
    • Year and Date
      2016-11-11
    • Data Source
      KAKENHI-PROJECT-26461120
  • [Presentation] Enhanced p122RhoGAP/DLC-1 Expression can be a Cause of Coronary Spasm2016

    • Author(s)
      金城貴彦、田中真実、長内智宏、澁谷修司、石田祐司、丹野倫宏、西崎公貴、市川博章、木村嘉宏、富田泰史、奥村謙
    • Organizer
      第80回日本循環器学会学術集会
    • Place of Presentation
      仙台国際センター(宮城県、仙台市)
    • Year and Date
      2016-03-20
    • Data Source
      KAKENHI-PROJECT-26461120
  • [Presentation] Coupling factor 6 accelerates aging by synchronizing primary aging hallmarks such as telomere attrition and a blocking effect of ATPase inhibitory factor 12016

    • Author(s)
      Tomohiro Osanai, Kei Izumiyama, Makoto Tanaka, Hirofumi Tomita, Akihiro Kobayashi, Ken Okumura
    • Organizer
      AHA Scientific Sessions 2016
    • Place of Presentation
      New Orleans, Louisiana, USA
    • Year and Date
      2016-11-12
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K09151
  • [Presentation] Disruption of A-kinase Anchoring Protein 150 Induces Coronary Spasm through Enhancement of Calcium Sensitization2016

    • Author(s)
      西崎公貴、富田泰史、市川博章、木村嘉宏、金城貴彦、丹野倫宏、田中真実、長内智宏、奥村謙
    • Organizer
      第80回日本循環器学会学術集会
    • Place of Presentation
      仙台国際センター(宮城県、仙台市)
    • Year and Date
      2016-03-20
    • Data Source
      KAKENHI-PROJECT-26461120
  • [Presentation] Coupling factor 6 is an endogenous stimulator for atherosclerosis through salt-sensitive hypertension and type 2 diabetes2015

    • Author(s)
      Tomohiro Osanai, Makoto Tanaka, Kei Izumiyama, Hirofumi Tomita, Ken Okumura
    • Organizer
      17TH International Congress on Atherosclerosis
    • Place of Presentation
      Amsterdam, Netherland
    • Year and Date
      2015-05-23
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K09151
  • [Presentation] 食塩はcoupling factor 6と同様に細胞内酸性化を介して老化スイッチをオンする2015

    • Author(s)
      長内智宏、泉山圭、富田泰史、奥村謙
    • Organizer
      第38回日本高血圧学会
    • Place of Presentation
      ひめぎんホール(愛媛県松山市)
    • Year and Date
      2015-10-09
    • Data Source
      KAKENHI-PROJECT-15K09151
  • [Presentation] Coronary Vasospasm Induced in Transgenic Mouse With Overexpression of p122RhoGAP/DLC12015

    • Author(s)
      Takahiko Kinjo, Makoto Tanaka, Tomohiro Osanai, Ikuyo Narita, Tomohiro Tannno, Kimitaka Nishizaki, Shuji Shibutani, Yuji Ishida, Hirofumi Tomita, Yoshimi Homma, and Ken Okumura
    • Organizer
      AHA2015
    • Place of Presentation
      オーランド市(アメリカ合衆国)
    • Year and Date
      2015-11-07
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26461120
  • [Presentation] Enhanced Trpc Channel-Mediated Ca2+ Influx in the Cells With Phospholipase C-δ1 Overexpression2014

    • Author(s)
      Murakami K, Okumura K.
    • Organizer
      AHA2014
    • Place of Presentation
      McCormick Place, Chicago, Illinois
    • Year and Date
      2014-11-16
    • Data Source
      KAKENHI-PROJECT-26461120
  • [Presentation] Plaque Erosion, Compared to Plaque Rupture, is Associated With Better Outcomes After Primary Percutaneous Coronary Intervention in Patients With STsegment Elevation Myocardial Infarction.2014

    • Author(s)
      Higumt T, Okumura K.
    • Organizer
      AHA2014
    • Place of Presentation
      McCormick Place, Chicago, Illinois
    • Year and Date
      2014-11-19
    • Data Source
      KAKENHI-PROJECT-26461120
  • [Presentation] Chronic Nuclear Acidosis Defines Aging and Lifespan by Histone 4 Lysine 5 Acetylation in Mice2014

    • Author(s)
      Osanai T, Okumura K.
    • Organizer
      AHA2014
    • Place of Presentation
      McCormick Place, Chicago, Illinois
    • Year and Date
      2014-11-19
    • Data Source
      KAKENHI-PROJECT-26461120
  • [Presentation] Coronary Vasospasm Induced in Transgenic Mouse With Vascular Smooth Muscle- Specific Overexpression of p122RhoGAP/ DLC1.2014

    • Author(s)
      Kinjo T, Okumura K.
    • Organizer
      AHA2014
    • Place of Presentation
      McCormick Place, Chicago, Illinois
    • Year and Date
      2014-11-16
    • Data Source
      KAKENHI-PROJECT-26461120
  • [Presentation] Enhanced TRP C Channel Mediated Ca2+ Influx may be Involved in the Drug Resistant Coronary Spasm Induced by Enhanced Phospholipase C-δ12013

    • Author(s)
      村上和男、奥村謙, 他
    • Organizer
      第78回日本循環器学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2013-03-23
    • Data Source
      KAKENHI-PROJECT-23591077
  • [Presentation] Altered Expression and Phosphorylation of L -type Calcium Channel in the Coronary Spastic Angina Mouse Model and the Effects of Diltiazem2013

    • Author(s)
      石田祐司、奥村謙, 他
    • Organizer
      第78回日本循環器学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2013-03-23
    • Data Source
      KAKENHI-PROJECT-23591077
  • [Presentation] Variant SUR2B Protein (R1546H) Detected in a Patient with Multivessel Coronary Artery Spasm2013

    • Author(s)
      澁谷修司、奥村謙, 他
    • Organizer
      第78回日本循環器学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2013-03-23
    • Data Source
      KAKENHI-PROJECT-23591077
  • [Presentation] Altered expression and phosphorylation levels of L-type calcium channel play a critical role in the mouse model of coronary spastic angina2013

    • Author(s)
      Ishida Y, Okumura K, et al.
    • Organizer
      米国心臓病学会(AHA2013)
    • Place of Presentation
      アメリカ合衆国(ダラス)
    • Year and Date
      2013-11-17
    • Data Source
      KAKENHI-PROJECT-23591077
  • [Presentation] Coupling factor 6 affects lifespan by reduced autophagy irrespectively of blood pressure.2012

    • Author(s)
      Tomohiro Osanai, Ken Okumura
    • Organizer
      アメリカ心臓協会学会 (AHA) 2012
    • Place of Presentation
      ロサンゼルス, カリフォルニア
    • Data Source
      KAKENHI-PROJECT-24591089
  • [Presentation] Coupling factor 6は細胞内酸性化を介してAutophagyを障害し細胞老化とLifespanの短縮を惹起する2012

    • Author(s)
      長内智宏、泉山圭、祐川誉徳、奥村謙
    • Organizer
      第35回日本高血圧学会総会
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PROJECT-24591089
  • [Presentation] Coupling factor 6は細胞内酸性化を介してRac1を活性化し食塩感受性高血圧とインスリン抵抗性を惹起する2011

    • Author(s)
      長内智宏、泉山圭、相楽繁樹、山本祐子、奥村謙
    • Organizer
      第34回日本高血圧学会総会
    • Place of Presentation
      宇都宮
    • Data Source
      KAKENHI-PROJECT-21590946
  • [Presentation] Coupling factor 6 induces tissue acidosis and thereby salt-sensitive hypertension with diabetes by Rac1 activation and insulin receptor inactivation2011

    • Author(s)
      Osanai T, Okumura K
    • Organizer
      Scientific Sessions 2011 (American Heart Association)
    • Place of Presentation
      Orland (USA)
    • Data Source
      KAKENHI-PROJECT-21590946
  • [Presentation] Coronary Vasospasm Induced In Transgenic Mice With Variant Phospholipase C-δ1(R257H)2010

    • Author(s)
      Shibutani S, Ken Okumura, et al
    • Organizer
      第74回アメリカ心臓病学会
    • Place of Presentation
      Orange County Convention Center Orlando, Fla.
    • Year and Date
      2010-11-15
    • Data Source
      KAKENHI-PROJECT-20590856
  • [Presentation] 頻発する心室性期外収縮へのアプローチ2010

    • Author(s)
      奥村謙
    • Organizer
      第74回日本循環器学会総会・学術集会
    • Place of Presentation
      国立京都国際会館
    • Year and Date
      2010-03-07
    • Data Source
      KAKENHI-PROJECT-20590856
  • [Presentation] 新規の細胞内pH調節機構F_1F_o complexはcoupling factor 6で活性化され血圧並びに糖代謝を調節する2010

    • Author(s)
      長内智宏、渋谷修司、花田賢二、泉山圭、相楽繁樹、山本祐子、奥村謙
    • Organizer
      第33回日本高血圧学会総会
    • Place of Presentation
      福岡
    • Data Source
      KAKENHI-PROJECT-21590946
  • [Presentation] Interaction between coupling factor 6 and ecto F1Fo complex induces hypertension and diabetes by tissue acidosis2010

    • Author(s)
      Osanai T, Okumura K
    • Organizer
      Scientific Sessions 2010 (American Heart Association)
    • Place of Presentation
      Chicago (USA)
    • Data Source
      KAKENHI-PROJECT-21590946
  • [Presentation] 新規の細胞内pH調節機構F_1F_o complexはcoupling factor 6で活性化され血圧並びに糖代謝を調節する2010

    • Author(s)
      長内智宏、渋谷修司、花田賢二、泉山圭、相楽繁樹、山本祐子、奥村謙
    • Organizer
      第33回日本高血圧学会総会
    • Place of Presentation
      福岡
    • Data Source
      KAKENHI-PROJECT-20590855
  • [Presentation] Coronary Vasospasm Induced In Transgenic Mice With Variant Phospholipase C-δ1(R257H).2010

    • Author(s)
      Shibutani S, Okumura K, et al
    • Organizer
      アメリカ心臓病学会(AHA)
    • Place of Presentation
      フロリダ
    • Year and Date
      2010-11-15
    • Data Source
      KAKENHI-PROJECT-20590856
  • [Presentation] 新規の昇圧物質coupling factor 6 はcSrcの活性化を介してangiotensin IIの収縮反応を亢進させる2009

    • Author(s)
      長内智宏、櫛引基、山田雅大、奥村謙
    • Organizer
      第32回日本高血圧学会総会
    • Data Source
      KAKENHI-PROJECT-21590946
  • [Presentation] Coupling factor 6 enhances the action of angiotensin II and causes insulin resistance in mice.2009

    • Author(s)
      長内智宏, 奥村謙
    • Organizer
      Scientific Sessions 2009 (American Heart Association)
    • Place of Presentation
      Orland (USA)
    • Data Source
      KAKENHI-PROJECT-20590855
  • [Presentation] Coupling factor 6 enhances the action of angiotensin II and causes insulin resistance in mice2009

    • Author(s)
      Osanai T, Okumura K
    • Organizer
      Scientific Sessions 2009 (American Heart Association)
    • Place of Presentation
      Orland (USA)
    • Data Source
      KAKENHI-PROJECT-21590946
  • [Presentation] Management of Atrial Fibrillation : Medical or Ablation2009

    • Author(s)
      奥村謙
    • Organizer
      第57回日本心臓病学会学術集会(第12回JCC-ACCジョイントシンポジウム)
    • Place of Presentation
      ロイトン札幌
    • Year and Date
      2009-09-20
    • Data Source
      KAKENHI-PROJECT-20590856
  • [Presentation] 新規の昇圧物質coupling factor 6はcSrcの活性化を介してangiotensin IIの収縮反応を亢進させる2009

    • Author(s)
      長内智宏、櫛引基、山田雅大、奥村謙
    • Organizer
      第32回日本高血圧学会総会
    • Data Source
      KAKENHI-PROJECT-20590855
  • [Presentation] カテーテルアブレーションの進歩-3次元マッピングの有用性について2009

    • Author(s)
      奥村謙
    • Organizer
      第107回日本循環器学会九州地方会
    • Place of Presentation
      宮崎県農協会館
    • Year and Date
      2009-12-05
    • Data Source
      KAKENHI-PROJECT-20590856
  • [Presentation] P122 protein, a positive regulator for phospholipase C-δ1, is upregulated and involved in enhanced calcium signaling in human coronary spasm2008

    • Author(s)
      Ken Okumura, et.al.
    • Organizer
      2008年米国心臓病学会(AHA)
    • Place of Presentation
      米国ニューオリンズ
    • Year and Date
      2008-11-10
    • Data Source
      KAKENHI-PROJECT-20590856
  • [Presentation] Overexpression of coupling factor 6 links hypertension to diabetes by c-Src-mediated signaling pathway in mice.2008

    • Author(s)
      Osanai T, Tanaka M, Echizen T, Ashitate T, Tomita H, Okumura K.
    • Organizer
      Scientific Sessions 2008 (American Heart Association)
    • Place of Presentation
      New Orleans (USA)
    • Data Source
      KAKENHI-PROJECT-20590855
  • [Presentation] Overexpression of coupling factor 6 links hypertension to diabetes by c-Src-mediated signaling pathway in mice2008

    • Author(s)
      Tomohiro Osanai, Makoto Tanaka,Takashi Echizen, Toshihiro Ashitate,Hirofumi Tomita, Ken Okumura
    • Organizer
      Scientific Sessions 2008(American Heart Association)
    • Place of Presentation
      NewOrleans (USA)
    • Data Source
      KAKENHI-PROJECT-19590800
  • [Presentation] 高血圧と糖尿病の病態形成における細胞内酸性化の意義 : Coupling factor 6過剰発現マウスを用いた解析2008

    • Author(s)
      長内智宏、芦立俊宗、越前 崇、山田雅大、奥村謙
    • Organizer
      第31回日本高血圧学会総会
    • Data Source
      KAKENHI-PROJECT-19590800
  • [Presentation] 高血圧と糖尿病の病態形成における細胞内酸性化の意義:Coupling factor 6過剰発現マウスを用いた解析2008

    • Author(s)
      長内智宏、芦立俊宗、越前崇、山田雅大、奥村謙
    • Organizer
      第31回日本高血圧学会総会
    • Data Source
      KAKENHI-PROJECT-20590855
  • [Presentation] Interaction between coupling factor 6 and ecto F1Fo complex induces hypertension and diabetes by tissue acidosis.2008

    • Author(s)
      長内智宏, 奥村謙
    • Organizer
      Scientific Sessions 2008 (American Heart Association)
    • Place of Presentation
      Chicago (USA)
    • Data Source
      KAKENHI-PROJECT-20590855
  • [Presentation] P122 Protein a positive regulator for phospholipase C-δ1, is upregulated and involved in enhanced calcium signaling in human coronary spasm.2008

    • Author(s)
      Okumura K, et al
    • Organizer
      アメリカ心臓病学会(AHA)
    • Place of Presentation
      ニューオリンズ
    • Year and Date
      2008-11-10
    • Data Source
      KAKENHI-PROJECT-20590856
  • [Presentation] p122 protein, a positive regulator for phospholipase C-δ1, is up-regulated human coronary spasm by-228G-A variant for the promoter2007

    • Author(s)
      Ken Okumura, et. al.
    • Organizer
      Scientific Sessions 2007, American Heart Association
    • Place of Presentation
      Orlando, FL, U. S. A.
    • Year and Date
      2007-11-06
    • Data Source
      KAKENHI-PROJECT-18590758
  • [Presentation] Coupling factor 6 activatesc-src by intracellular acidosis and enhances calcium signaling in resistance arterioles vascular smooth muscle cells2007

    • Author(s)
      Tomohiro Osanai, Makoto Tanaka,Hirofumi Tomita, Masahiro Yamada, Reiichi Murakami, Toshihiro Ashitate, Takashi Echizen, Chisato Katoh, Hiroaki Yokoyama, Ken Okumura
    • Organizer
      Scientific Session 2007 (American Heart Association)
    • Place of Presentation
      Orland(USA)
    • Data Source
      KAKENHI-PROJECT-19590800
  • [Presentation] 新規の昇圧物質coupling factor 6の細胞内情報伝達機構とカルシウムシグナル2007

    • Author(s)
      長内智宏、芦立俊宗、斎藤 新、奥村謙
    • Organizer
      第30回日本高血圧学会総会
    • Data Source
      KAKENHI-PROJECT-19590800
  • [Presentation] p122 protein, a positive regulator for phospholipase C-δ1, is up-regulated human coronary spasm by-228G-A variant for the promoter2007

    • Author(s)
      Ken Okumura, et. al.
    • Organizer
      Scientific Sessions 2007, American Heart Association
    • Place of Presentation
      Orlando, FL, U.S.A.
    • Year and Date
      2007-11-06
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18590758
  • [Presentation] Altered expression and phosphorylation levels of L-type calcium channel play a critical role in the mouse model of coronary spastic angina.

    • Author(s)
      Ishida Y, Okumura K.
    • Organizer
      2013年米国心臓病学会議 (AHA2013)
    • Place of Presentation
      アメリカ合衆国(ダラス)
    • Data Source
      KAKENHI-PROJECT-23591077
  • [Presentation] Coupling factor 6は核内酸性化による核膜ラミナ構造異常を介して老化・寿命を規定する

    • Author(s)
      長内智宏、泉山圭、山田雅大、樋熊拓未、富田泰史、奥村謙
    • Organizer
      第37回日本高血圧学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2014-10-17 – 2014-10-19
    • Data Source
      KAKENHI-PROJECT-24591089
  • [Presentation] Chronic nuclear acidosis defines aging and lifespan by histone 4 lysine 5 acetylation in mice.

    • Author(s)
      Osanai T, Okumura K
    • Organizer
      Scientific Sessions 2014 (American Heart Association)
    • Place of Presentation
      Chicago (USA)
    • Year and Date
      2014-11-15 – 2014-11-19
    • Data Source
      KAKENHI-PROJECT-24591089
  • 1.  OSANAI Tomohiro (00169278)
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    # of Collaborated Products: 106 results
  • 2.  YASUE Hirofumi (40174502)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 0 results
  • 3.  OGAWA Hisao (50177135)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 1 results
  • 4.  FUJII Hiromi (40199295)
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  • 5.  MATSUYAMA Koshi (00190546)
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  • 6.  SASAKI Singo (20344591)
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    # of Collaborated Products: 1 results
  • 7.  YAMABE Hiroshige (20419641)
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  • 8.  MATSUYAMA Kouzaburo (20229587)
    # of Collaborated Projects: 1 results
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  • 9.  KUGIYAMA Kiyotaka (00225129)
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    # of Collaborated Products: 0 results
  • 10.  HANADA Hiroyuki (20250615)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  IWASA Atsushi (70312486)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  KAMADA Takaatsu (90281930)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  MATSUNAGA Toshiro (40344593)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  HORIO Yutaka (50157070)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  Tomita Hirofumi (00431437)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 32 results
  • 16.  KOYAMA Junjiro
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 17.  MORIHISA Kenji
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 18.  KANAZAWA Hisanori
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 19.  HOSHIYAMA Tadashi
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 20.  高岡 恭治
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  NAKAMURA Natsuki
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 22.  ROKUTANDA Manabu
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 23.  TAKAOKA Kyoji
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 24.  SEYA Kazuhiko
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 25.  NAKAMURA Norio
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 26.  大島 吉輝
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 27.  久保原 禅
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 28.  村上 学
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 29.  古川 賢一
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 30.  尾野 恭一
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 31.  黒瀬 顕
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 32.  今泉 忠淳
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 33.  松宮 朋穂
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 34.  吉田 秀見
    # of Collaborated Projects: 0 results
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  • 35.  佐藤 敬
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