OZAWA Shogo 小沢正吾

… Alternative Names

小沢正吾オザワショウゴ

小澤正吾オザワショウゴ

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Researcher Number	20185581
External Links
Affiliation (based on the past Project Information) *help	2007 – 2009: 岩手医科大学, 薬学部, 教授 2006: 国立医薬品食品衛生研究所, 薬理部, 室長 1999 – 2001: 国立医薬品食品衛生研究所, 薬理部, 室長 1994: 慶応義塾大学, 医学部, 助手 1993 – 1994: 慶應義塾大学, 医学部, 助手 1990: 慶應義塾大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Environmental pharmacy / 応用薬理学・医療系薬学 Except Principal Investigator 応用薬理学・医療系薬学 / Human pathology / Laboratory medicine
Keywords	Principal Investigator phytoestrogens / estrogen responsiveness / gene expression / detoxification / Sulfotransferase / Drug Metabolizing enzymes / Human / Estrogenicity / 代謝活性化 / 植物エストロゲン … More / エストロゲン応答性 / 遺伝子発現 / 解毒的代謝 / 硫酸転移酵素 / 薬物代謝酵素 / ヒト / 内分泌撹乱作用 / cDNAの発現系 / 癌原性N-ヒドロキシアリールアミン / cDNAクローニング / フェノール硫酸転移酵素 … More Except Principal Investigator 代謝的活性化 / Gene expression / Sulfotransferase / Acetyltransferase / Metabolic activation / Drug metabolizing enzymes / Carcinogenicity / Mutagenicity / Ames test / ベンチジン / サルモネラ菌 / N,O‐アセチル転移反応 / アリルアミン / 異所遺伝子発現 / アセチル化酵素遺伝子 / アセチル化酵素 / Anes試験 / 異種細胞内発現 / 硫酸転移酵素 / アセチル転移酵素 / 代謝活性化 / 薬物代謝酵素 / 発癌性 / 変異原性 / Ames試験 / エピジェネティクス / 薬剤感受性 / ゲノム不安定化 / 癌 / コピー数多型 / ヒトゲノム / 薬剤反応性 / GeneChip / 網羅的解析 / gene dosage effect / 薬物動態関連遺伝子 / 遺伝子多型 / CNV / 遺伝子コピー数多型 / 遺伝的多型 / メフェニトイン / チトクロームP450 / 薬理遺伝学 / 酵素欠損 / 個人差 / 薬物代謝 / 副作用 / 癌原性アリルアミン / 分子クローニング / スルホトランスフェラーゼ / ベンズピレン水酸化 / メフェニトイン水酸化 / 癌原物質 / 遺伝薬理学 / チトクロムPー450 Less

Estimation of the role of genomic instability on drug response and its application for cancer chemotherapy.
- Principal Investigator
  
  HABANO Wataru
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Iwate Medical University
Development of the Analytical Methods for the Evaluation of Copy Number Variations of Drug Metabolizing Enzyme Related Genes in Japanese Population
- Principal Investigator
  
  ISHIDA Seiichi
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  National Institute of Health Sciences
Biochemical and molecular mechanisms of beneficial effects for human health by phytoestrogensPrincipal Investigator
- Principal Investigator
  
  OZAWA Shogo
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Environmental pharmacy
- Research Institution
  National Institute of Health Sciences
癌原物質の活性化を行うヒト肝スルホトランスフェラーゼの構造と遺伝的多型の解析
- Principal Investigator
  
  山添康
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Keio University
薬物代謝酵素の欠損及び多型に起因する副作用発現の分子薬理学的解析
- Principal Investigator
  
  安盛俊雄
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Keio University
フェノール硫酸転移酵素の機能及びその遺伝的欠損と疾患との関連Principal Investigator
- Principal Investigator
  
  小沢正吾
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Keio University
Establishment of high sensitive Salmonella tester strains expressing mammalian acetvltransferase and sulfotransferase
- Principal Investigator
  
  KATO Ryuichi
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Keio University
癌原物質の活性化を行うヒト肝チトクロムPー450の薬理遺伝学差異の研究
- Principal Investigator
  
  KATO Ryuichi
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Keio University

All 2011 2010 2009 2007

All Journal Article Presentation Book

[Book] How DNA microarray technology contributes to the retinoid evaluations. In "Vitamin A : New Research" (Ed. Lossing IT.)2007
- Author(s)
  Ishida S, Tanabe H, Shinozaki Y, Koyano S, Kagechika H, Shudo K, Ozawa S, Sawada JI, Ohno Y, Inoue K.
- Publisher
  Nova Scientific Publishers, Inc.
- Data Source
  KAKENHI-PROJECT-18590545
[Journal Article] Altered expression of GADD45 genes during the development of chemical-mediated liver hypertrophy and liver tumor promotion in rats2011
- Author(s)
  Ozawa S, Gamou T, Habano W, et al
- Journal Title
  
  The Journal of Toxicological Sciences
  
  Volume: 36 Issue: 5 Pages: 613-623
- DOI
  10.2131/jts.36.613
- NAID
  10029481415
- ISSN
  0388-1350, 1880-3989
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590402
[Journal Article] Super-induced gene expression of the N-methyl-D-aspartate receptor 2C subunit in chemical-induced hypertrophic liver in rats2011
- Author(s)
  Nemoto K, Tanaka T, Ikeda A, Ito S, Mizukami M, Hikida T, Gamou T, Habano W, Ozawa S, Inoue K, Yoshida M, Nishikawa A, Degawa M.
- Journal Title
  
  J Toxicol Sci
  
  Volume: 36(5) Pages: 507-14
- NAID
  10029481028
- Data Source
  KAKENHI-PROJECT-21590402
[Journal Article] Induction of CYP1 family members under low-glucose conditions requires AhR expression and occurs through the nuclear translocation of AhR2011
- Author(s)
  Terashima J, Habano W, Gamou T, Ozawa S.
- Journal Title
  
  Drug Metab Pharmacokinet
  
  Volume: 26(6) Pages: 577-83
- NAID
  130004933497
- Data Source
  KAKENHI-PROJECT-21590402
[Journal Article] Involvement of promoter methylation in the regulation of Pregnane X receptor in colon cancer cells2011
- Author(s)
  Habano W, Gamo T, Terashima J, Sugai T, Otsuka K, Wakabayashi G, Ozawa S.
- Journal Title
  
  BMC Cancer
  
  Volume: 11 Pages: 81-81
- NAID
  130004640031
- Data Source
  KAKENHI-PROJECT-21590402
[Journal Article] Altered expression of GADD45 genes during the development of chemical-mediated liver hypertrophy and liver tumor promotion in rats2011
- Author(s)
  Ozawa S, Gamou T, Habano W, Inoue K, Yoshida M, Nishikawa A, Nemoto K, Degawa M.
- Journal Title
  
  J Toxicol Sci
  
  Volume: 36(5) Pages: 613-23
- NAID
  10029481415
- Data Source
  KAKENHI-PROJECT-21590402
[Journal Article] Induction of CYP1 Family Members under Low-glucose Conditions Requires AhR Expression and Occurs through the Nuclear Translocation of AhR2011
- Author(s)
  Terashima J, Habano W, Gamou T, Ozawa S
- Journal Title
  
  Drug Metabolism and Pharmacokinetics
  
  Volume: 26 Issue: 6 Pages: 577-583
- DOI
  10.2133/dmpk.DMPK-11-RG-054
- NAID
  130004933497
- ISSN
  1347-4367, 1880-0920
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590402
[Journal Article] CYP1B1, but not CYP1A1, is downregulated by promoter methylation in colorectal cancers2009
- Author(s)
  Habano W, Gamo T, Sugai T, Otsuka K, Wakabayashi G, Ozawa S.
- Journal Title
  
  Int J Oncol
  
  Volume: 34(4) Pages: 1085-1
- Data Source
  KAKENHI-PROJECT-21590402
[Presentation] Global DNA methylation analysis in Caco-2 and LS180 colon cancer cells2011
- Author(s)
  Habano W, Gamou T, Terashima J, Ozawa S.
- Organizer
  日本薬物動態学会第26回年会
- Place of Presentation
  広島
- Year and Date
  2011-11-16
- Data Source
  KAKENHI-PROJECT-21590402
[Presentation] Global DNA methylation analysis in Caco-2 and LS180 colon cancer cells2011
- Author(s)
  Habano W, Gamou T, Terashima J, Ozawa S
- Organizer
  日本薬物動態学会第26回年回
- Place of Presentation
  広島国際会議場(広島市)
- Year and Date
  2011-11-16
- Data Source
  KAKENHI-PROJECT-21590402
[Presentation] Involvement of promoter methylation in the regulation of Pregnane X receptor in colon cancer cells2010
- Author(s)
  Habano W, Gamou T, Terashima J, Sugai T, Ozawa
- Organizer
  日本薬物動態学会第25回年会
- Place of Presentation
  さいたま
- Year and Date
  2010-10-08
- Data Source
  KAKENHI-PROJECT-21590402
[Presentation] Methylation of PXR, VDR, and PRMT1 genes and their roles in the regulation of CYP3A4 expression in colon cancer cells2009
- Author(s)
  Habano W, Gamou T, Terashima J, Sugai T, Ozawa
- Organizer
  日本薬物動態学会第24回年会
- Place of Presentation
  京都
- Year and Date
  2009-11-27
- Data Source
  KAKENHI-PROJECT-21590402
[Presentation] Analysis of Copy Number Variations (CNVs) of Drug Metabolizing Enzyme Related Genes in Japanese2007
- Author(s)
  Ishida S, Tanabe H, Sawada JI, Ozawa S, Nakazawa K.
- Organizer
  8th International ISSX Meeting
- Place of Presentation
  Sendai
- Year and Date
  2007-10-09
- Data Source
  KAKENHI-PROJECT-18590545

1. YASUMORI Toshio (70182350)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
2. YAMAZOE Yasushi (00112699)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
3. KATO Ryuichi (40112685)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. NAGATA Kiyoshi (80189133)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. TANABE Hideyuki (50261178)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
6. ISHIDA Seiichi (10270505)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
7. HABANO Wataru (50332979)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
8. 蒲生俊恵 (00464701)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 菅井有 (20187628)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
10. FUJITA Masataka

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

OZAWA Shogo 小沢 正吾

小沢 正吾 オザワ ショウゴ

小澤 正吾 オザワ ショウゴ

Research Projects

Research Products

Co-Researchers

Estimation of the role of genomic instability on drug response and its application for cancer chemotherapy.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of the Analytical Methods for the Evaluation of Copy Number Variations of Drug Metabolizing Enzyme Related Genes in Japanese Population

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Biochemical and molecular mechanisms of beneficial effects for human health by phytoestrogensPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

癌原物質の活性化を行うヒト肝スルホトランスフェラーゼの構造と遺伝的多型の解析

Principal Investigator

Project Period (FY)

Research Category

Research Institution

薬物代謝酵素の欠損及び多型に起因する副作用発現の分子薬理学的解析

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

フェノール硫酸転移酵素の機能及びその遺伝的欠損と疾患との関連Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Establishment of high sensitive Salmonella tester strains expressing mammalian acetvltransferase and sulfotransferase

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

癌原物質の活性化を行うヒト肝チトクロムPー450の薬理遺伝学差異の研究

Principal Investigator

Project Period (FY)

Research Category

Research Institution

[Book] How DNA microarray technology contributes to the retinoid evaluations. In "Vitamin A : New Research" (Ed. Lossing IT.)2007

Author(s)

Publisher

Data Source

[Journal Article] Altered expression of GADD45 genes during the development of chemical-mediated liver hypertrophy and liver tumor promotion in rats2011

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] Super-induced gene expression of the N-methyl-D-aspartate receptor 2C subunit in chemical-induced hypertrophic liver in rats2011

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Induction of CYP1 family members under low-glucose conditions requires AhR expression and occurs through the nuclear translocation of AhR2011

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Involvement of promoter methylation in the regulation of Pregnane X receptor in colon cancer cells2011

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Altered expression of GADD45 genes during the development of chemical-mediated liver hypertrophy and liver tumor promotion in rats2011

OZAWA Shogo 小沢正吾

小沢正吾オザワショウゴ

小澤正吾オザワショウゴ