Ishida Seiichi 石田誠一

… Alternative Names

Researcher Number	10270505
Other IDs
Affiliation (Current)	2019: 国立医薬品食品衛生研究所, 薬理部, 室長
Affiliation (based on the past Project Information) *help	2011 – 2016: 国立医薬品食品衛生研究所, 薬理部, 室長 2013: 国立医薬品食品衛生研究所, 薬理部第三室, 室長 2007 – 2009: National Institute of Health Sciences, 薬理部, 室長 2006: 国立医薬品食品衛生研究所, 薬理部, 主任研究官 1996: 癌研究会癌研究所, 遺伝子, 研究員
Review Section/Research Field	Principal Investigator Laboratory medicine Except Principal Investigator Biofunction/Bioprocess / Biofunction/Bioprocess / General pharmacology / Applied pharmacology
Keywords	Principal Investigator CNV / GeneChip / コピー数多型 / ヒトゲノム / 網羅的解析 / gene dosage effect / 遺伝子多型 / 薬剤反応性 / 遺伝子コピー数多型 / 薬物動態関連遺伝子 … More Except Principal Investigator … More

Studies on the evaluation method for chemical compound toxicity to human hepatocytes by using hollow fiber type three dimensional culture module
- Principal Investigator
  
  MATSUSHITA Taku
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biofunction/Bioprocess
- Research Institution
  Sojo University
Expression of drug resisitance phenomena of cancer cells by 3D-culture and its application to development of new assay system for anti-cancer drugs
- Principal Investigator
  
  MATSUSHITA Taku
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biofunction/Bioprocess
- Research Institution
  Sojo University
Proliferation of breast cancer stem cells via NO/cGMP signaling pathway
- Principal Investigator
  
  KANDA Yasunari
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  National Institute of Health Sciences
マイクロRNAによる薬物トランスポーターの発現制御と遺伝子多型影響の解明
- Principal Investigator
  
  斎藤嘉朗
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied pharmacology
- Research Institution
  National Institute of Health Sciences
Development of the Analytical Methods for the Evaluation of Copy Number Variations of Drug Metabolizing Enzyme Related Genes in Japanese PopulationPrincipal Investigator
- Principal Investigator
  
  ISHIDA Seiichi
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  National Institute of Health Sciences
p53癌抑制遺伝子によるヒト発がん抑制の分子機構
- Principal Investigator
  
  土田信夫
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tokyo Medical and Dental University

All 2016 2015 2014 2013 2007 Other

All Journal Article Presentation Book

[Book] How DNA microarray technology contributes to the retinoid evaluations. In "Vitamin A : New Research" (Ed. Lossing IT.)2007
- Author(s)
  Ishida S, Tanabe H, Shinozaki Y, Koyano S, Kagechika H, Shudo K, Ozawa S, Sawada JI, Ohno Y, Inoue K.
- Publisher
  Nova Scientific Publishers, Inc.
- Data Source
  KAKENHI-PROJECT-18590545
[Journal Article] Upregulations of metallothionein gene expressions and tolerance to heavy metal toxicity by three dimensional cultivation of HepG2 cells on VECELL 3-D inserts2016
- Author(s)
  T. Kubo, Y. Kuroda, S. Horiuchi, SR. Kim, Y. Sekino, S. Ishida
- Journal Title
  
  J. Toxicol. Sci.
  
  Volume: 41 Issue: 1 Pages: 147-153
- DOI
  10.2131/jts.41.147
- ISSN
  0388-1350, 1880-3989
- Language
  English
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26420804
[Journal Article] Inflammatory cytokines promote the retrodifferentiation of tumor-derived hepatocyte-like cells to progenitor cells2014
- Author(s)
  H. Dubois-Pot-Schneider, K. Fekir, C. Coulouarn,D. Glaise, C. Aninat, K. Jarnouen, R. Le Guevel, T. Kubo, S. Ishida, F. Morel, A. Corlu
- Journal Title
  
  Hepatology
  
  Volume: 60 Pages: 2077-2090
- DOI
  10.1002/hep.27353
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26420804
[Journal Article] Comparative metabolome analysis of cultured fetal and adult hepatocytes in humans2014
- Author(s)
  S.-R. Kim, T. Kubo, Y. Kuroda, M. Hojyo, T. Matsuo, A. Miyajima, M. Usami, Y. Sekino, T. Matsushita, S. Ishida
- Journal Title
  
  J. Toxicol. Sci.
  
  Volume: 40 Issue: 5 Pages: 438-442
- DOI
  10.2131/jts.39.717
- ISSN
  0388-1350, 1880-3989
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26420804
[Journal Article] Involvement of decreased glutamate receptor subunit GluR2 expression in lead-induced neuronal cell death2013
- Author(s)
  Ishida K., Kotake Y., Miyara M., Aoki K., Sanoh S., Kanda Y., Ohta S.
- Journal Title
  
  J. Toxicol. Sci.
  
  Volume: 38 Issue: 3 Pages: 513-21
- DOI
  10.2131/jts.38.513
- ISSN
  0388-1350, 1880-3989
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590322
[Journal Article] Developing and standardizing experimental protocols using human iPS-derived cells to predict adverse drug reactions in pre-clinical safety studies2013
- Author(s)
  Sekino Y, Sato K, Kanda Y, Ishida S.
- Journal Title
  
  Kokuritsu Iyakuhin Shokuhin Eisei Kenkyusho Hokoku
  
  Volume: 131 Pages: 25-34
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590322
[Presentation] 胎児肝細胞及び成人肝細胞のメタボローム解析と化学物質毒性発現の比較解析（第三報）2016
- Author(s)
  白木明日香, 市川雄大, 稲村恒亮, 水民敬浩, 古水雄志, 石田誠一, 金秀良, 関野祐子, 松下琢
- Organizer
  第29回日本動物実験代替法学会
- Place of Presentation
  九州大学百年講堂福岡県福岡市
- Year and Date
  2016-11-16
- Data Source
  KAKENHI-PROJECT-26420804
[Presentation] 胎児肝細胞及び成人肝細胞のメタボローム解析と化学物質毒性発現の比較解析（第二報）2015
- Author(s)
  市川雄大、松下琢、石井貴晃、古水雄志、金　秀良、石田誠一、宮島敦子、関野祐子
- Organizer
  日本動物実験代替法学会第28回大会
- Place of Presentation
  ワークピア横浜（神奈川県横浜市）
- Year and Date
  2015-12-10
- Data Source
  KAKENHI-PROJECT-26420804
[Presentation] ヒト胎児および成人肝細胞のメタボローム解析による基礎代謝機能と関連する遺伝子発現の比較解析2014
- Author(s)
  金秀良、久保崇、黒田幸恵、北条麻紀、宮島敦子、松下琢、関野祐子、石田誠一
- Organizer
  第58回日本薬学会関東支部大会
- Place of Presentation
  昭和薬科大学（東京都町田市）
- Year and Date
  2014-10-04
- Data Source
  KAKENHI-PROJECT-26420804
[Presentation] Comparative analysis of human fetal hepatocytes and adult hepatocytes by metabolomics and toxicity test2013
- Author(s)
  S.Ishida
- Organizer
  日本薬物動態学会第28回大会
- Place of Presentation
  東京都江戸川区タワーホール船堀
- Year and Date
  2013-10-10
- Data Source
  KAKENHI-PROJECT-23560951
[Presentation] Analysis of Copy Number Variations (CNVs) of Drug Metabolizing Enzyme Related Genes in Japanese2007
- Author(s)
  Ishida S, Tanabe H, Sawada JI, Ozawa S, Nakazawa K.
- Organizer
  8th International ISSX Meeting
- Place of Presentation
  Sendai
- Year and Date
  2007-10-09
- Data Source
  KAKENHI-PROJECT-18590545
[Presentation] 胎児及び成人肝細胞のメタボロームと化学物質毒性発現の比較解析
- Author(s)
  市川雄大、石井貴晃、古水雄志、松下琢、金秀良、石田誠一、宮島敦子、関野裕子
- Organizer
  日本動物実験代替法学会　第29回大会
- Place of Presentation
  横浜国立大学（神奈川県横浜市）
- Year and Date
  2014-12-05 – 2014-12-07
- Data Source
  KAKENHI-PROJECT-26420804
[Presentation] 胎児及び成人肝細胞のメタボロームと化学物質毒性発現の比較解析
- Author(s)
  松下琢, 石井貴晃, 市川雄大, 金秀良, 石田誠一, 宮島敦子, 関野祐子
- Organizer
  日本組織培養学会第 87 回大会
- Place of Presentation
  星陵会館（東京都千代田区）
- Year and Date
  2014-05-29 – 2014-05-30
- Data Source
  KAKENHI-PROJECT-26420804
[Presentation] Comparative analysis of human fetal hepatocytes and adult hepatocytes by metabolomics and toxicity test
- Author(s)
  S. Ishida, S-R. Kim, T. Kubo, Y. Kuroda, M. Hojyo, A. Miyajima, T. Matsushita, Y. Sekino
- Organizer
  日本薬物動態学会第28回大会
- Place of Presentation
  東京都江戸川区タワーホール船堀
- Data Source
  KAKENHI-PROJECT-23560951
[Presentation] ヒト胎児肝細胞と成人肝細胞における基礎代謝機能と関連する遺伝子発現の比較解析
- Author(s)
  石田誠一、金秀良、久保崇、黒田幸恵、北条麻紀、宮島敦子、松下琢、関野祐子
- Organizer
  第41回日本毒性学会学術年会
- Place of Presentation
  神戸コンベンションセンター（兵庫県神戸市）
- Year and Date
  2014-07-02 – 2014-07-04
- Data Source
  KAKENHI-PROJECT-26420804

1. OZAWA Shogo (20185581)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. TANABE Hideyuki (50261178)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
3. MATSUSHITA Taku (10209538)

# of Collaborated Projects: 2 results

# of Collaborated Products: 8 results
4. MATSUMOTO Yoko (00133562)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. KANDA Yasunari (70510387)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
6. 土田信夫 (60089951)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 山下利春 (50167706)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 高橋玲 (60144565)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 山泉克 (70107093)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 横田淳 (10191503)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 斎藤嘉朗 (50215571)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 佐井君江 (20195960)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 古水雄志 (80735829)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
14. 小沢正吾

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Ishida Seiichi 石田 誠一

ISHIDA Seiichi 石田 誠一

石田 誠一 イシダ セイイチ

Research Projects

Research Products

Co-Researchers

Studies on the evaluation method for chemical compound toxicity to human hepatocytes by using hollow fiber type three dimensional culture module

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Expression of drug resisitance phenomena of cancer cells by 3D-culture and its application to development of new assay system for anti-cancer drugs

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Proliferation of breast cancer stem cells via NO/cGMP signaling pathway

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

マイクロRNAによる薬物トランスポーターの発現制御と遺伝子多型影響の解明

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of the Analytical Methods for the Evaluation of Copy Number Variations of Drug Metabolizing Enzyme Related Genes in Japanese PopulationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

p53癌抑制遺伝子によるヒト発がん抑制の分子機構

Principal Investigator

Project Period (FY)

Research Category

Research Institution

[Book] How DNA microarray technology contributes to the retinoid evaluations. In "Vitamin A : New Research" (Ed. Lossing IT.)2007

Author(s)

Publisher

Data Source

[Journal Article] Upregulations of metallothionein gene expressions and tolerance to heavy metal toxicity by three dimensional cultivation of HepG2 cells on VECELL 3-D inserts2016

Author(s)

Journal Title

DOI

ISSN

Language

Data Source

[Journal Article] Inflammatory cytokines promote the retrodifferentiation of tumor-derived hepatocyte-like cells to progenitor cells2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Comparative metabolome analysis of cultured fetal and adult hepatocytes in humans2014

Author(s)

Journal Title

DOI

ISSN

Language

Data Source

[Journal Article] Involvement of decreased glutamate receptor subunit GluR2 expression in lead-induced neuronal cell death2013

Author(s)

Journal Title

DOI

ISSN

Language

Data Source

[Journal Article] Developing and standardizing experimental protocols using human iPS-derived cells to predict adverse drug reactions in pre-clinical safety studies2013

Author(s)

Journal Title

Data Source

[Presentation] 胎児肝細胞及び成人肝細胞のメタボローム解析と化学物質毒性発現の比較解析（第三報）2016

Author(s)

Organizer

Place of Presentation

Year and Date

Ishida Seiichi 石田誠一

ISHIDA Seiichi 石田誠一

石田誠一イシダセイイチ