Takai Toshiyuki 高井俊行

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TAKAI Toshiyuki 高井俊行

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Researcher Number	20187917
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Affiliation (Current)	2025: 東北大学, 加齢医学研究所, 特任教授
Affiliation (based on the past Project Information) *help	2023 – 2024: 東北大学, 加齢医学研究所, 特任教授 1998 – 2022: 東北大学, 加齢医学研究所, 教授 1993 – 1997: 岡山大学, 工学部, 助教授 1989: Okayama University, Faculty of Engineering Lecturer, 工学部, 講師 1988: 岡山大学, 工学部, 助手
Review Section/Research Field	Principal Investigator Biological Sciences / Immunology / General medical chemistry / General medical chemistry / 生物・生体工学 / Medium-sized Section 50:Oncology and related fields / Medium-sized Section 49:Pathology, infection/immunology, and related fields / Basic Section 49070:Immunology-related / Pathology, Infection/Immunology, and related fields / Immunology / Pathological medical chemistry … More Except Principal Investigator … More Integrative animal science / General medical chemistry / Pathological medical chemistry / Pediatrics / Immunology Less
Keywords	Principal Investigator 免疫制御 / Fcレセプター / アレルギー / 自己免疫疾患 / PIR / 遺伝子ターゲティング / 自己免疫 / 自己抗体 / 免疫抑制 / 遺伝子欠損マウス … More / 制御受容体 / 炎症 / PIR-B / allergy / 自然免疫 / インテグリン / 免疫チェックポイント / Allergy / 自己免疫病 / イムノグロブリン様受容体 / がん免疫 / dendritic cell / Th2 response / GVHD / transplantation / gp49 / NK細胞 / 抗体療法 / immunoregulation / autoimmunity / Ig-like receptor / Gene Targeting / IgG / B細胞 / 制御性受容体 / B-1細胞 / 移植免疫 / 抑制受容体 / 免疫学 / シグナル伝達 / 抗原提示 / 樹状細胞 / マスト細胞 / inhibitory receptor / MHC class I / 細胞分化 / キラーレセプター / 抑制性シグナル / Fc受容体 / ES細胞 / 細胞外マトリクス / 焦点接着斑 / スカベンジャー / フィブロネクチン / アルツハイマー病 / ミクログリア / 免疫調節 / チェックポイント / がん転移 / 細胞外マトリックス / シグナル制御 / 細胞接着 / 免疫制御・移植免疫 / 免疫シグナル伝達 / 免疫寛容・自己免疫 / 免疫記憶 / 免疫抑制受容体 / 病原性プラズマセル / 免疫抑制分子 / 形質細胞 / LILRファミリー / 皮膚筋炎 / 全身性エリテマトーデス / 免疫寛容 / レセプター / Fc receptor / Intravenous immunoglobulin / Autoantibodies / Immunoglobulin / Autoimmune disease / Immune regulation / 糖尿病 / アレルギー・ぜんそく / 膵島炎 / NODマウス / 大量免疫グロブリン療法 / 自己免疫性糖尿病 / IVIG / 免疫グロブリン / gene targeting / IgLR / Model construction_ / FcγRIIB / Autoimmunity / グッドパスチャー症候群 / コラーゲン関節炎 / リウマチ / Immuomodulation / Inhibitory Receptor / Immunoglobulin-like Receptor / INHIBITORY SIGNAL / NK RECEPTOR / IGA / GENE-DEFICIENT MICE / ALLERGY / IMMUNOREGULATION / FC RECEPTOR / GENE TARGETING / NKレセプター / IgA / 遺伝子ターゲテイング / 血小板 / サイトカイン / ヒト単球 / IL-10 / 抑制シグナル / 抗炎症 / B1細胞 / 免疫制御能 / 末梢血Bリンバ球 / γグロブリン製剤 / 末梢血Bリンパ球 / PirB / 抗体産生 / B細胞分化 / 免疫受容体 / プロファイリング / 自然抗体 / 予防診断技術 / ランダムペプチド / マイクロアレイ / 抗体 / 免疫疾患 / がん / 受容体 / TLP9 / Btk / MHCクラスI / リウマチ因子 / 自己抗体産生 / 骨形成 / IgL受容体 / 破骨細胞 / 抑制レセプター / presenile dementia / Schizophrenia / immunoglobulin-like receptor / Oligodendrocyte / Nasu-Hakola disease / DAP12 / ターゲティング / ヒスタミン / アナフィラキシー / mast cell / エフェクター機能 / 免疫制御機構 / ノックアウトマウス … More Except Principal Investigator mRNA / PP2C / TAK1 / IL-1 / SAPK / Th2 / 消化管上皮 / 腸間膜リンパ節 / 寄生虫 / 自然リンパ球 / メモリー応答 / サイトカイン / T細胞 / 小腸 / 樹状細胞 / 2型サイトカイン / 線虫 / Biotin / Acetyl-CoA carboxylase / Metabolic regulation / Fatty acid biosynthesis / アセチルCoAカルボキシラーゼ / 代謝調節調節 / 構造 / メッセンジャ-RNA / ビオチン / アセチルCoAカルボキシラ-ゼ / 代謝調節 / 脂肪酸生合成 / signaling pathway / SAPKシステム / ストレス反応 / プロテインホスファターゼ / 環境ストレス / プロテインホスファターゼ2C / SAPKシグナル伝達路 / ストレス応答 / シグナル伝達路 / LILRB / plasmablast / 免疫グロブリン大量療法 / LILRB4 / 免疫抑制性受容体 / 川崎病 / 細胞外基質 / 白血球浸潤 / 炎症反応 / Fcレセプター / 接着分子 / ケモカイン Less

Innovative elucidation of myeloid immune checkpoint LILRB functionPrincipal Investigator
- Principal Investigator
  
  高井俊行
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 50:Oncology and related fields
- Research Institution
  Tohoku University
Role of immune checkpoint molecules in microglia and Alzheimer's diseasePrincipal Investigator
- Principal Investigator
  
  TAKAI Toshiyuki
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 49:Pathology, infection/immunology, and related fields
- Research Institution
  Tohoku University
Mechanism of LILRB4-mediated immune checkpointPrincipal Investigator
- Principal Investigator
  
  TAKAI Toshiyuki
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49070:Immunology-related
- Research Institution
  Tohoku University
Modulating immunological memory of antibody-producing cellsPrincipal Investigator
- Principal Investigator
  
  TAKAI Toshiyuki
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Research Field
  
  Pathology, Infection/Immunology, and related fields
- Research Institution
  Tohoku University
Identification of molecular characteristics of pathogenic autoantibody-producing cellsPrincipal Investigator
- Principal Investigator
  
  TAKAI Toshiyuki
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Immunology
- Research Institution
  Tohoku University
The role of immunosuppressive receptor LILRB in the pathogenesis of Kawasaki disease, and its application to the therapy.
- Principal Investigator
  
  Kumaki Satoru
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Department of Clinical Research, National Hospital Organization Sendai Medical Center
Platelets convert peripheral blood circulating monocytes to regulatory cells via immunoglobulin G and activating-type Fcg receptors.Principal Investigator
- Principal Investigator
  
  TAKAI Toshiyuki
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Immunology
- Research Institution
  Tohoku University
The role and networks of immune and nonimmune cells in the small intestine in the early stage of gastrointestinal parasite infection.
- Principal Investigator
  
  MORIMOTO Motoko
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Integrative animal science
- Research Institution
  Miyagi University
Novel immune regulation by PirB-related multiple ligandsPrincipal Investigator
- Principal Investigator
  
  TAKAI Toshiyuki
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  General medical chemistry
- Research Institution
  Tohoku University
Elucidation of Regulatory Mechanism of B1 Cells by Human IgG Natural AntibodiesPrincipal Investigator
- Principal Investigator
  
  TAKAI TOSHIYUKI
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Immunology
- Research Institution
  Tohoku University
免疫抑制受容体PIR-Bによる自己応答性の制御Principal Investigator
- Principal Investigator
  
  高井俊行
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tohoku University
Prediction of immune disorders by evaluation of serum IgG reactivity to random peptide libraryPrincipal Investigator
- Principal Investigator
  
  TAKAI Toshiyuki
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  General medical chemistry
- Research Institution
  Tohoku University
免疫抑制受容体PIRーBによる自己応答性の制御Principal Investigator
- Principal Investigator
  
  高井俊行
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tohoku University
Molecular Basis for the Immune Regulatory Receptor SystemPrincipal Investigator
- Principal Investigator
  
  TAKAI Toshiyuki
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Immunology
- Research Institution
  Tohoku University
免疫抑制レセプターgp49B/LILRB4の新機能に関する研究Principal Investigator
- Principal Investigator
  
  高井俊行
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  General medical chemistry
- Research Institution
  Tohoku University
イムノグロブリン様受容体分子郡による破骨細胞分化制御に関する研究Principal Investigator
- Principal Investigator
  
  高井俊行
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  General medical chemistry
- Research Institution
  Tohoku University
Pre-Translational Approaches to the Conquest of Immune Disorders by Targeting Fcγ ReceptorsPrincipal Investigator
- Principal Investigator
  
  TAKAI Toshiyuki
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Immunology
- Research Institution
  Tohoku University
Fc受容体による中枢神経系の制御機構Principal Investigator
- Principal Investigator
  
  高井俊行
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  General medical chemistry
- Research Institution
  Tohoku University
IMMUNE REGULATION BY IMMUNOGLOBULIN-LIKE RECEPTORSPrincipal Investigator
- Principal Investigator
  
  TAKAI Toshiyuki
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Immunology
- Research Institution
  Tohoku University
NK細胞の分化におけるFcR,KAR,gp49の役割に関する研究Principal Investigator
- Principal Investigator
  
  高井俊行
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Review Section
  
  Biological Sciences
- Research Institution
  Tohoku University
Fc受容体を介したIgE,IgGによるマスト細胞機能の調節Principal Investigator
- Principal Investigator
  
  高井俊行
- Project Period (FY)
  2000 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tohoku University
樹状細胞Fcγ受容体へのがん抗原ターゲティングによるがん免疫賦活方法の開発Principal Investigator
- Principal Investigator
  
  高井俊行
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Tohoku University
Development of Autoimmune Disease Models Based on FcyRIIB-Deficient MicePrincipal Investigator
- Principal Investigator
  
  TAKAI Toshiyuki
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Tohoku University
ナチュラルキラー細胞の分化におけるFcR,KAR,gp49の役割に関する研究Principal Investigator
- Principal Investigator
  
  高井俊行
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Review Section
  
  Biological Sciences
- Research Institution
  Tohoku University
炎症のバイオサイエンスの新しい展開
- Principal Investigator
  
  宮坂昌之
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  Osaka University
Analysis of Physiological Roles of Novel Immunoglobulin-Like Receptors, PIRPrincipal Investigator
- Principal Investigator
  
  TAKAI Toshiyuki
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Tohoku University
Molecular mechanism of response of living body to environmental stress
- Principal Investigator
  
  TAMURA Shinri
- Project Period (FY)
  1998 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Tohoku University
Fcレセプター欠損マウスを用いたアレルギーの分子機構の解明とその修復法の開発Principal Investigator
- Principal Investigator
  
  高井俊行
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Okayama University
ANALYSIS OF IGA NETWORK BY GENE TARGETINGPrincipal Investigator
- Principal Investigator
  
  TAKAI Toshiyuki
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  OKAYAMA UNIVERSITY
Fc受容体遺伝子ノックアウトマウスを用いた免疫制御機構の解析Principal Investigator
- Principal Investigator
  
  高井俊行
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Okayama University
遺伝子ターゲティングによるFcγ受容体欠損マウスの作成およびその解析に関する研究Principal Investigator
- Principal Investigator
  
  高井俊行
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  生物・生体工学
- Research Institution
  Okayama University
遺伝子ノックアウト法による免疫グロブリンGFc受容体の機能解析Principal Investigator
- Principal Investigator
  
  高井俊行
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  生物・生体工学
- Research Institution
  Okayama University
Molecular biological study on the regulation of fatty acid biosynthesis
- Principal Investigator
  
  TANABE Tadashi
- Project Period (FY)
  1988 – 1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  National Cardiovascular Center Research Institute

[Book] 医学のあゆみ自己免疫病とPirB(245)2013
- Author(s)
  乾匡範,高井俊行
- Data Source
  KAKENHI-PROJECT-24659215
[Book] Clin Calcium 免疫グロプリン様受容体による破骨細胞の分化制御(22(11))2012
- Author(s)
  乾匡範,高井俊行
- Data Source
  KAKENHI-PROJECT-24659215
[Book] Paired immunoglobulin-like receptor(PIR)-Bの自己免疫疾患における役割2011
- Author(s)
  中村晃, 高井俊行
- Publisher
  科学評論社
- Data Source
  KAKENHI-PROJECT-22659057
[Book] 骨髄球系細胞におけるMDL-1/DAP12の機能2011
- Author(s)
  北口公司, 遠藤章太, 乾匡範, 高井俊行
- Publisher
  科学評論社
- Data Source
  KAKENHI-PROJECT-22659057
[Book] Adv Exp Med Biol.640(Fc receptor targeting in the treatment of allergy, autoimmune diseases and cancer.)2008
- Author(s)
  Nakamura A, Kubo T, Takai T
- Data Source
  KAKENHI-PROJECT-20249026
[Journal Article] Gp49B is a pathogenic marker for autoantibody-producing plasma cells in lupus-prone BXSB/Yaa mice2019
- Author(s)
  Wong Yi Li、Su Mei-Tzu、Sugahara-Tobinai Akiko、Itoi So、Kezuka Dai、Endo Shota、Inui Masanori、Takai Toshiyuki
- Journal Title
  
  International Immunology
  
  Volume: 印刷中 Issue: 6 Pages: 397-406
- DOI
  10.1093/intimm/dxz017
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08874, KAKENHI-PROJECT-16H05201, KAKENHI-PROJECT-16J01922, KAKENHI-PROJECT-19H03484
[Journal Article] Augmented ILT3/LILRB4 Expression of Peripheral Blood Antibody Secreting Cells in the Acute Phase of Kawasaki Disease2019
- Author(s)
  Sugahara-Tobinai Akiko、Inui Masanori、Metoki Takaya、Watanabe Yohei、Onuma Ryoichi、Takai Toshiyuki、Kumaki Satoru
- Journal Title
  
  The Pediatric Infectious Disease Journal
  
  Volume: 38 Issue: 4 Pages: 431-438
- DOI
  10.1097/inf.0000000000002259
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08874, KAKENHI-PROJECT-19H03484
[Journal Article] Bone marrow PDGFRa+Sca-1+ enriched mesenchymal stem cells support survival of and antibody production by plasma cells in vitro through IL-6.2018
- Author(s)
  Atsuko Kayaba, Ari Itoh-Nakadai, Kunimichi Niibe, Matsuyuki Shirota, Ryo Funayama, Akiko Sugahara-Tobinai, Yi Li Wong, Masanori Inui, Keiko Nakayama, and Toshiyuki Takai.
- Journal Title
  
  Int Immu
  
  Volume: in press Issue: 6 Pages: 241-253
- DOI
  10.1093/intimm/dxy018
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K19539, KAKENHI-PROJECT-17K15714, KAKENHI-PROJECT-17H04035, KAKENHI-PROJECT-15KK0328, KAKENHI-PROJECT-17K08874, KAKENHI-PROJECT-16K20480
[Journal Article] EXPLORING OF IMMUNE INHIBITORY RECEPTORS THAT CHARACTERIZE PATHOGENIC PLASMA CELLS IN SYSTEMIC LUPUS ERYTHEMATOSUS2017
- Author(s)
  Takai T, Inui M.
- Journal Title
  
  Japanese Journal of Allergology
  
  Volume: 66 Issue: 1 Pages: 27-31
- DOI
  10.15036/arerugi.66.27
- NAID
  130005394544
- ISSN
  0021-4884, 1347-7935
- Language
  Japanese
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16H05201, KAKENHI-PROJECT-26461597
[Journal Article] Tolerogenic immunoreceptor ILT3/LILRB4 paradoxically marks pathogenic auto-antibody-producing plasmablasts and plasma cells in non-treated SLE.2016
- Author(s)
  Inui M, Sugahara-Tobinai A, Fujii H, Itoh-Nakadai A, Fukuyama H, Kurosaki T, Ishii T, Harigae H, Takai T.
- Journal Title
  
  Int Immunol.
  
  Volume: Dec;28(12) Issue: 12 Pages: 597-604
- DOI
  10.1093/intimm/dxw044
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16H05201, KAKENHI-PROJECT-26461597
[Journal Article] Targeting cell surface TLR7 for therapeutic intervention in autoimmune diseases.2015
- Author(s)
  Kanno A, Tanimura N, Ishizaki M, Ohko K, Motoi Y, Onji M, Fukui R, Shimozato T, Yamamoto K, Shibata T, Sano S, Sugahara-Tobinai A, Takai T, Ohto U, Shimizu T, Saitoh S, Miyake K.
- Journal Title
  
  Nat Commun
  
  Volume: 6 Pages: 6119-6119
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26670230
[Journal Article] Immune complexes regulate bone metabolism through FcRγ signaling.2015
- Author(s)
  Nehishi–Koga T, Gober HJ, Sumiya E, Komatsu N, Okamoto K, Sawa S, Suematsu S, Suda T, Sato K, Takai T, Takayanagi H.
- Journal Title
  
  Nat Commun
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26670230
[Journal Article] Platelets convert peripheral blood circulating monocytes to regulatory cells via immunoglobulin G and activating-type Fcγ receptors.2015
- Author(s)
  Inui M, Tazawa K, Kishi Y, Takai T.
- Journal Title
  
  BMC Immunol.
  
  Volume: in press
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24249016
[Journal Article] Human CD43+ B cells are closely related not only to memory B cells phenotypically but also to plasmablasts developmentally in healthy individuals.2015
- Author(s)
  Inui M, Hirota S, Hirano K, Fujii H, Sugahara-Tobinai A, Ishii T, Harigae H, Takai T.
- Journal Title
  
  Int Immunol.
  
  Volume: pii
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24249016
[Journal Article] Immune complexes regulate bone metabolism through FcRγ signalling2015
- Author(s)
  Negishi-Koga T, Gober HJ, Sumiya E, Komatsu N, Okamoto K, Sawa S, Suematsu A, Suda T, Sato K, Takai T, Takayanagi H.
- Journal Title
  
  Nat Commun
  
  Volume: 6 Issue: 1 Pages: 6637-6637
- DOI
  10.1038/ncomms7637
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-25111503, KAKENHI-PROJECT-25670188, KAKENHI-PROJECT-25670228, KAKENHI-PROJECT-15K10488, KAKENHI-PROJECT-26461597, KAKENHI-PROJECT-15K15538, KAKENHI-PROJECT-15H05653, KAKENHI-PROJECT-15F15414, KAKENHI-PROJECT-13J40074, KAKENHI-PROJECT-15H05703
[Journal Article] Human CD43+ B cells are closely related not only to memory B cells phenotypically but also to plasmablasts developmentally in healthy individuals.2015
- Author(s)
  Inui M, Hirota S, Hirano K, Fujii H, Sugahara-Tobinai A, Ishii T, Harigae H, Takai T
- Journal Title
  
  Internationa Immunology
  
  Volume: 27 Issue: 7 Pages: 345-55
- DOI
  10.1093/intimm/dxv009
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09515, KAKENHI-PROJECT-26461597
[Journal Article] Endoplasmic protein Nogo-B (RTN4-B) interacts with GRAMD4 and regulates TLR9-mediated innate immune responses.2015
- Author(s)
  Kimura T, Endo S, Inui M, Saitoh S-i, Miyake K, Takai T.
- Journal Title
  
  J. Immunol.
  
  Volume: in press
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24249016
[Journal Article] Targeting cell surface TLR7 for therapeutic intervention in autoimmune diseases.2015
- Author(s)
  Kanno A, Tanimura N, Ishizaki M, Ohko K, Motoi Y, Onji M, Fukui R, Shimozato T, Yamamoto K, Shibata T, Sano S, Sugahara-Tobinai A, Takai T, Ohto U, Shimizu T, Saitoh S, Miyake K.
- Journal Title
  
  Nat Commun
  
  Volume: 6 Pages: 6119-6119
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24249016
[Journal Article] Endoplasmic protein Nogo-B (RTN4-B) interacts with GRAMD4 and regulates TLR9-mediated innate immune responses.2015
- Author(s)
  Kimura T, Endo S, Inui M, Saitoh S-i, Miyake K, Takai T.
- Journal Title
  
  J. Immunol.
  
  Volume: in press
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26670230
[Journal Article] A DAP12-Dependent Signal Promotes Pro-Inflammatory Polarization in Microglia Following Nerve Injury and Exacerbates Degeneration of Injured Neurons2015
- Author(s)
  Kobayashi M, Konishi H, Takai T, Kiyama H.
- Journal Title
  
  Glia
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26670230
[Journal Article] Endoplasmic Protein Nogo-B (RTN4-B) Interacts with GRAMD4 and Regulates TLR9-Mediated Innate Immune Responses.2015
- Author(s)
  Kimura T, Endo S, Inui M, Saitoh S, Miyake K, Takai T.
- Journal Title
  
  J Immunol.
  
  Volume: 194 Issue: 11 Pages: 5426-5436
- DOI
  10.4049/jimmunol.1402006
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26461597, KAKENHI-PROJECT-26293083
[Journal Article] A DAP12-Dependent Signal Promotes Pro-Inflammatory Polarization in Microglia Following Nerve Injury and Exacerbates Degeneration of Injured Neurons.2015
- Author(s)
  Kobayashi M, Konishi H, Takai T, Kiyama H.
- Journal Title
  
  Glia
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24249016
[Journal Article] Platelets convert peripheral blood circulating monocytes to regulatory cells via immunoglobulin G and activating-type Fc receptors.2015
- Author(s)
  Inui M, Tazawa K, Kishi Y, Takai T.
- Journal Title
  
  BMC Immunol.
  
  Volume: in press
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26670230
[Journal Article] A DAP12-Dependent Signal Promotes Pro-Inflammatory Polarization in Microglia Following Nerve Injury and Exacerbates Degeneration of Injured Neurons.2015
- Author(s)
  Kobayashi M, Konishi H, Takai T, Kiyama H.
- Journal Title
  
  Glia
  
  Volume: 63 Issue: 6 Pages: 1073-1082
- DOI
  10.1002/glia.22802
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26461597, KAKENHI-PROJECT-25830050, KAKENHI-PLANNED-23111007
[Journal Article] Targeting cell surface TLR7 for therapeutic intervention in autoimmune diseases2015
- Author(s)
  Kanno A, Tanimura N, Ishizaki M, Ohko K, Motoi Y, Onji M, Fukui R, Shimozato T, Yamamoto K, Shibata T, Sano S, Sugahara-Tobinai A, Takai T, Ohto U, Shimizu T, Saitoh S, Miyake K.
- Journal Title
  
  Nature Communications
  
  Volume: 6 Issue: 1 Pages: 6119-6119
- DOI
  10.1038/ncomms7119
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-13J40043, KAKENHI-PROJECT-25253032, KAKENHI-PROJECT-25460585, KAKENHI-PROJECT-25670189, KAKENHI-PROJECT-26293083, KAKENHI-PROJECT-26670235, KAKENHI-PROJECT-26461597, KAKENHI-PROJECT-25291010
[Journal Article] Human CD43+ B cells are closely related not only to memory B cells phenotypically but also to plasmablasts developmentally in healthy individuals.2015
- Author(s)
  Inui M*, Hirota S*, Hirano K, Fujii H, Sugahara-Tobinai A, Ishii T, Harigae H, Takai T.
- Journal Title
  
  Int Immunol.
  
  Volume: pii
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26670230
[Journal Article] Immune complexes regulate bone metabolism through FcRγ signaling.2015
- Author(s)
  Nehishi–Koga T, Gober HJ, Sumiya E, Komatsu N, Okamoto K, Sawa S, Suematsu S, Suda T, Sato K, Takai T, Takayanagi H.
- Journal Title
  
  Nat Commun
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24249016
[Journal Article] Platelets convert peripheral blood circulating monocytes to regulatory cells via immunoglobulin G and activating-type Fcγ receptors.2015
- Author(s)
  Inui M, Tazawa K, Kishi Y, Takai T.
- Journal Title
  
  BMC Immunol.
  
  Volume: 16 Issue: 1 Pages: 20-20
- DOI
  10.1186/s12865-015-0086-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26461597, KAKENHI-PROJECT-26670230
[Journal Article] TREM-1 regulates macrophage polarization in ureteral obstruction.2014
- Author(s)
  Lo TH, Tseng KY, Tsao WS, Yang CY, Hsieh SL, Chiu AW, Takai T, Mak TW, Tarng DC, Chen NJ.
- Journal Title
  
  Kidney Int.
  
  Volume: 86(6) Issue: 6 Pages: 1174-1186
- DOI
  10.1038/ki.2014.205
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24249016, KAKENHI-PROJECT-26670230
[Journal Article] An ITAM-Syk-CARD9 signaling axis triggers contact hypersensitivity by stimulating IL-1 production in dendritic cells2014
- Author(s)
  Yasukawa. S., Miyazaki, Y., Yoshii, C., Nakaya, M., Ozaki, N., Toda, S., Kuroda, E., Ishibashi, K., Yasuda, T., Natsuaki, Y., Mi-ichi, F., Iizasa, E., Nakahara, T., Yamazaki, M., Kabashima, K., Iwakura, Y., Takai, T., Saito, T., Kurosaki, T., Malissen, B., Ohno, N., Furue, M., Yoshida, H., and Hara, H
- Journal Title
  
  Nature Comm
  
  Volume: 5 Issue: 1 Pages: 3755-3755
- DOI
  10.1038/ncomms4755
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21229007, KAKENHI-PROJECT-24229004, KAKENHI-PROJECT-24249016, KAKENHI-PROJECT-24390256, KAKENHI-PROJECT-24591145, KAKENHI-PROJECT-25460594, KAKENHI-PUBLICLY-26117719, KAKENHI-PROJECT-26670230
[Journal Article] Gp49B-mediated negative regulation of antibody production by memory and marginal zone B cells.2014
- Author(s)
  Fukao S, Haniuda K, Nojima T, Takai T, Kitamura D.
- Journal Title
  
  J Immunol.
  
  Volume: 193 Issue: 2 Pages: 635-644
- DOI
  10.4049/jimmunol.1302772
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-ORGANIZER-24111001, KAKENHI-PROJECT-24249016, KAKENHI-PUBLICLY-25111512, KAKENHI-PUBLICLY-25118730, KAKENHI-PROJECT-25293116, KAKENHI-PROJECT-26670230, KAKENHI-PROJECT-26670239
[Journal Article] Dichotomy in the FcγRIIB deficiency and autoimmune-prone SLAM haplotype clarifies the roles of the Fc receptor in development of autoantibodies and glomerulonephritis.2014
- Author(s)
  Kanari Y, Sugahara–Tobinai A, Takahashi H, Inui M, Nakamura A, Hirose S, Takai T.
- Journal Title
  
  BMC Immunol
  
  Volume: 15 Issue: 1 Pages: 47-47
- DOI
  10.1186/s12865-014-0047-y
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24249016, KAKENHI-PROJECT-24590491, KAKENHI-PROJECT-24590572, KAKENHI-PROJECT-25460601
[Journal Article] Dichotomy in the FcγRIIB deficiency and autoimmune-prone SLAM haplotype clarifies the roles of the Fc receptor in development of autoantibodies and glomerulonephritis.2014
- Author(s)
  Kanari Y, Sugahara–Tobinai A, Takahashi H, Inui M, Nakamura A, Hirose S, Takai T.
- Journal Title
  
  BMC Immunol
  
  Volume: 15 Pages: 47-47
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26670230
[Journal Article] The long-term immunosuppressive effects of disulfide-linked HLA-G dimer in mice with collagen-induced arthritis.2013
- Author(s)
  Kuroki Kら
- Journal Title
  
  Hum Immunol.
  
  Volume: 74 Issue: 4 Pages: 433-438
- DOI
  10.1016/j.humimm.2012.11.060
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22370043, KAKENHI-PROJECT-23770102, KAKENHI-PROJECT-24249016, KAKENHI-PROJECT-24659215, KAKENHI-PROJECT-25709080
[Journal Article] Phenotype conversion from rheumatoid arthritis to systemic lupus erythematosus by introduction of Yaa mutation into FcgRIIB-deficient C57BL/62013
- Author(s)
  Kawano S, Lin Q, Amano H, Kaneko T, Nishikawa K, Tsurui H, Tada N, Nishimura H,Takai T, Shirai T, Takasaki Y and Hirose S
- Journal Title
  
  mice.
  
  Volume: 43 Issue: 3 Pages: 770-778
- DOI
  10.1002/eji.201243057
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590194, KAKENHI-PROJECT-23591450, KAKENHI-PROJECT-24249016, KAKENHI-PROJECT-24590491, KAKENHI-PROJECT-24659215, KAKENHI-PROJECT-25330349, KAKENHI-PROJECT-25461486
[Journal Article] IgG and IgE collaboratively accelerate expulsion of Strongyloides venezuelensis in a primary infection.2013
- Author(s)
  Makoto Matsumoto, Yuki Sasaki, Koubun Yasuda, Toshiyuki Takai, Masamichi Muramatsu, Tomohiro Yoshimoto, Kenji Nakanishi.
- Journal Title
  
  Infection and Immunity
  
  Volume: Vol.81、No.7 Issue: 7 Pages: 2518-2527
- DOI
  10.1128/iai.00285-13
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590384, KAKENHI-PROJECT-23249022, KAKENHI-PROJECT-23790450, KAKENHI-PROJECT-24249016, KAKENHI-PROJECT-24390253, KAKENHI-PROJECT-24659215, KAKENHI-PROJECT-24659226, KAKENHI-PROJECT-25460521
[Journal Article] Role of TREM1-Dap12 in renal inflammation during obstructive nephropathy.2013
- Author(s)
  Stroo I, Tammarro A, Rampanelli E, Blank F, Butter L, Claessen N, Takai T, Colonna M, Leemans J, Florquin S, Dessing MC.
- Journal Title
  
  PLOS ONE
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24249016
[Journal Article] Role of TREM1-Dap12 in renal inflammation during obstructive nephropathy2013
- Author(s)
  Stroo I,Tammarro A,Rampanelli E,Blank F,Butter L,Claessen N,Takai T,Colonna M,Leemans J,Florquin S,Dessing MC.
- Journal Title
  
  PLOS ONE
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659215
[Journal Article] Environmental factors determine DAP12 deficiency to either enhance or suppress immunopathogenic processes.2013
- Author(s)
  Montalvo V, Quigley L, Vistica BP, Boelte KC, Nugent LF, Takai T, McVicar DW, Gery I.
- Journal Title
  
  Immunology
  
  Volume: Dec;140(4) Issue: 4 Pages: 475-482
- DOI
  10.1111/imm.12158
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24249016, KAKENHI-PROJECT-24659215
[Journal Article] Role of TREM1-Dap12 in renal inflammation during obstructive nephropathy.2013
- Author(s)
  Stroo I, Tammarro A, Rampanelli E, Blank F, Butter L, Claessen N, Takai T, Colonna M, Leemans J, Florquin S, Dessing MC.
- Journal Title
  
  PLOS ONE
  
  Volume: 8(12) Issue: 12 Pages: e82498-e82498
- DOI
  10.1371/journal.pone.0082498
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659215
[Journal Article] Intravenous immunoglobulin suppresses IL-10 production by activated B cells in vitro2012
- Author(s)
  Tanaka J
- Journal Title
  
  Open J. Immunol.
  
  Volume: vol. 2 Issue: 04 Pages: 149-160
- DOI
  10.4236/oji.2012.24019
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24249016, KAKENHI-PROJECT-24590572, KAKENHI-PROJECT-24659215
[Journal Article] Regulation of plasmacytoid dendritic cell responses by PIR-B.2012
- Author(s)
  MitsuhashiY,NakamuraA,EndoS,TakedaK,Yabe-WadaT,NukiwaT,TakaiT(correspondenceauthor)
- Journal Title
  
  Blood
  
  Volume: 120 Issue: 16 Pages: 3256-3259
- DOI
  10.1182/blood-2012-03-419093
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590431, KAKENHI-PROJECT-24249016, KAKENHI-PROJECT-24659215
[Journal Article] Deletion of cognate CD8 T-cells by immature dendritic cells: a novel role for perforin, Granzyme A, TREM-1 and TLR72012
- Author(s)
  Zangi L
- Journal Title
  
  Blood
  
  Volume: 120 Issue: 8 Pages: 1647-57
- DOI
  10.1182/blood-2012-02-410803
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24249016, KAKENHI-PROJECT-24659215
[Journal Article] Inhibitory receptor PIR-B is exploited by Staphylococcus aureus for virulence2012
- Author(s)
  Nakayama M, Kurokawa K, Nakamura K, Lee BL, Sekimizu K, Kubagawa H, Hiramatsu K, Yagita H, Okumura K, Takai T, Underhill DM, Aderem A, Ogasawara K.
- Journal Title
  
  J Immunol
  
  Volume: 189 Issue: 12 Pages: 5903-5911
- DOI
  10.4049/jimmunol.1201940
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390370, KAKENHI-PROJECT-23249009, KAKENHI-PROJECT-23390260, KAKENHI-PROJECT-23659291, KAKENHI-PROJECT-24249016, KAKENHI-PROJECT-24590158, KAKENHI-PROJECT-24659215
[Journal Article] Runx1 deficiency in CD4+ T cells causes fatal autoimmune inflammatory lung disease due to spontaneous hyperactivation of cells.2012
- Author(s)
  Wong WF, Tazawa R, （15名略）Nakata K, Takai T, Satake M.
- Journal Title
  
  J Immunol.
  
  Volume: 188(11) Issue: 11 Pages: 5408-5420
- DOI
  10.4049/jimmunol.1102991
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22242001, KAKENHI-PROJECT-22590431, KAKENHI-PROJECT-22590852, KAKENHI-PROJECT-23390219, KAKENHI-PROJECT-23659498, KAKENHI-PROJECT-24249016, KAKENHI-PROJECT-24330219, KAKENHI-PROJECT-24390118, KAKENHI-PROJECT-24659174, KAKENHI-PROJECT-24659215, KAKENHI-PROJECT-24659487
[Journal Article] Mycobacterial hypersensitivity pneumonitis requires TLR9-MyD88 in lung CD11b+ CD11c+ cells2011
- Author(s)
  Daito H, Kikuchi T, Sakakibara T, Gomi K, Damayanti T, Zaini J, Tode N, Kanehira M, Koyama S, Fujimura S, Ebina M, Ishii KJ, Akira S, Takai T, Watanabe A, Nukiwa T
- Journal Title
  
  Eur Respir J
  
  Volume: 38 Issue: 3 Pages: 688-701
- DOI
  10.1183/09031936.00177110
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249052, KAKENHI-PROJECT-22659057, KAKENHI-PROJECT-23390219
[Journal Article] Paired immunoglobulin-like receptor B knockout does not enhance axonal regeneration or locomotor recovery after spinal cord injury.2011
- Author(s)
  Nakamura, Y., Fujita, Y., Ueno, M., Takai, T., Yamashita, T.
- Journal Title
  
  J.Biol.Chem. 286(3)Epub 2010 Nov 18
  
  Pages: 1876-1883
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249026
[Journal Article] An immunoreceptor adapter protein, DAP12, suppresses adaptive immune responses mediated by B lymphocytes.2011
- Author(s)
  Nakano-Yokomizo T, Tahara-Hanaoka S, Nakahashi-Oda C, Nabekura T, Tchao NK, Kadosaki M, Totsuka N, Kurita N, Nakamagoe K, Tamaoka A, Takai T, Yasui T, Kikutani H, Honda S, Shibuya K, Lanier LL, Shibuya A.
- Journal Title
  
  J.Exp.Med. in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249026
[Journal Article] Presumptive role of 129 strain-derived Sle16 locus in rheumatoid arthritis in a new mouse model with Fcy receptor type Iib-deficient C57BL/6 genetic background.2011
- Author(s)
  Sato-Hayashizaki A, Ohtsuji M, Lin Q, Hou R, Ohtsuji N, Nishikawa K, Tsurui H, Sudo K, Ono M, Izui S, Shirai T, Takai T, Nishimura H, Hirose S
- Journal Title
  
  Arthritis & Rheumatism
  
  Volume: 63 Issue: 10 Pages: 2930-2938
- DOI
  10.1002/art.30485
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590194, KAKENHI-PROJECT-22659057, KAKENHI-PROJECT-23591450
[Journal Article] Paired immunoglobulin like receptor-B regulates the suppressive function and fate of myeloid derived suppressor cells.2011
- Author(s)
  Ma G, Pan PY, Eisenstein S, Divino CM, Lowell C, Takai T, Chen SH
- Journal Title
  
  Immunity 34
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249026
[Journal Article] Differential but competitive binding of Nogo and MHCI to PIR-B provides an inhibition of cells2011
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  Matsushita H, et al
- Journal Title
  
  J.Biol.Chem.
  
  Volume: 286(29) Issue: 29 Pages: 25739-25747
- DOI
  10.1074/jbc.m110.157859
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-22021004, KAKENHI-PLANNED-22121007, KAKENHI-PROJECT-22370043, KAKENHI-PROJECT-22590431, KAKENHI-PROJECT-22659057, KAKENHI-PUBLICLY-23133501
[Journal Article] Paired immunoglobulin like receptor-B regulates the suppressive function and fate of myeloid derived suppressor cells2011
- Author(s)
  Ma G, Pan PY, Eisenstein S, Divino CM, Lowell C, Takai T, Chen SH
- Journal Title
  
  Immunity
  
  Volume: 34 Issue: 3 Pages: 385-395
- DOI
  10.1016/j.immuni.2011.02.004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22659057
[Journal Article] Transcriptional activation of the Pirb gene in B cells by PU.1 and Runx32011
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  Arita K, et al
- Journal Title
  
  J.Immunol.
  
  Volume: 186(12) Issue: 12 Pages: 7050-7059
- DOI
  10.4049/jimmunol.1001302
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-22021004, KAKENHI-PROJECT-22590431, KAKENHI-PROJECT-22659057
[Journal Article] Myelin suppresses axon regeneration by PIR-B/SHP-mediated inhibition of Trk activity.2011
- Author(s)
  Fujita Y, Endo S, Takai T, Yamashita T.
- Journal Title
  
  EMBO J. 6;30(7)Epub2011 Mar 1.
  
  Pages: 1389-1401
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249026
[Journal Article] Myelin suppresses axon regeneration by PIR-B/SHP-mediated inhibition of Trk activity2011
- Author(s)
  Fujita Y, Endo S, Takai T, Yamashita T
- Journal Title
  
  EMBO J
  
  Volume: 30(7) Pages: 1389-401
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22659057
[Journal Article] Control of pathogenic CD4 T cells and lethal immunopathology by signaling immunoadaptor DAP12 during influenza infection2011
- Author(s)
  McCormick S, Shaler CR, Small CL, Horvath C, Damjanovic D, Brown EG, Aoki N, Takai T, Xing Z
- Journal Title
  
  J Immunol
  
  Volume: 187(8) Issue: 8 Pages: 4280-92
- DOI
  10.4049/jimmunol.1101050
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22659057
[Journal Article] Mycobacterial hypersensitivity pneumonitis requires TLR9 - MyD88 in lungCD11b^+CD11c^+ cells.2011
- Author(s)
  Daito H, Kikuchi T, Sakakibara T, Gomi K, Damayanti T, Zaini J, Tode N, Kanehira M, Koyama S, Fujimura S, Ebina M, Ishii KJ, Akira S, Takai T, Watanabe A, Nukiwa T.
- Journal Title
  
  Eur.Respir.J.
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249026
[Journal Article] An immunoreceptor adapter protein, DAP12, suppresses adaptive immune responses mediated by B lymphocytes2011
- Author(s)
  Nakano-Yokomizo T, Tahara-Hanaoka S, Nakahashi-Oda C, Nabekura T, Tchao NK, Kadosaki M, Totsuka N, Kurita N, Nakamagoe K, Tamaoka A, Takai T, Yasui T, Kikutani H, Honda S, Shibuya K, Lanier LL, Shibuya A
- Journal Title
  
  J. Exp. Med
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22659057
[Journal Article] Interaction between NK cells and dendritic cells generate MHC class II-dressed NK cells to regulate CD4^+ T cells2011
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  Nakayama M, et al
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  Proc.Natl.Acad.Sci.USA
  
  Volume: 108 Issue: 45 Pages: 18360-18365
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  10.1073/pnas.1110584108
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390114, KAKENHI-PROJECT-22659057, KAKENHI-PUBLICLY-23112519, KAKENHI-PROJECT-23300355
[Journal Article] The p75 receptor mediates axon growth inhibition through an association with PIR-B2011
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  Fujita Y, et al
- Journal Title
  
  Cell Death Dis.
  
  Volume: 2 Issue: 9 Pages: e198-e198
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  10.1038/cddis.2011.85
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-22021004, KAKENHI-PROJECT-22659057
[Journal Article] Transcriptional activation of the Pirb gene in B cells by PU.1 and Runx3.2011
- Author(s)
  Arita K, Endo S, Kaifu T, Kitaguchi K, Nakamura A., Ohmori H, Kofu K, Satake M, Takai T.
- Journal Title
  
  J.Immunol. in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249026
[Journal Article] The inhibitory effects of intravenous administration of rabbit IgG on airway inflammation are dependent on Fcgamma receptor IIb on CD11c+ dendritic cells in murine model2010
- Author(s)
  Yamamoto M, Kobayashi K, Ishikawa Y, Nakata K, Funada Y, Kotani Y, Masuda A, Takai T, Azuma T, Yoshida M, Nishimura Y
- Journal Title
  
  Clin. Exp. Immunol
  
  Volume: 162(2) Pages: 315-24
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22659057
[Journal Article] Paired immunoglobulin-like receptor B knockout does not enhance axonal regeneration or locomotor recovery after spinal cord injury2010
- Author(s)
  Nakamura, Y., Fujita, Y., Ueno, M., Takai, T. Yamashita, T.
- Journal Title
  
  Biol. Chem
  
  Volume: 286(3) Pages: 1876-83
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22659057
[Journal Article] Role of PIR-B in Autoimmune Glomerulonephritis.(Review)2010
- Author(s)
  Takai T, Nakamura A, Endo S.
- Journal Title
  
  J.Biomed.Biotech. vol.2011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249026
[Journal Article] Role of PIR-B in Autoimmune Glomerulonephritis2010
- Author(s)
  Takai T, Nakamura A, Endo S.
- Journal Title
  
  J. Biomed. Biotech
  
  Volume: vol.2011 Pages: 275302-275302
- Data Source
  KAKENHI-PROJECT-22659057
[Journal Article] The inhibitory effects of intravenous administration of rabbit IgG on airway inflammation are dependent on Fcgamma receptor IIb on CD11c+ dendritic cells in murine model.2010
- Author(s)
  Yamamoto M, Kobayashi K, Ishikawa Y, Nakata K, Funada Y, Kotani Y, Masuda A, Takai T, Azuma T, Yoshida M, Nishimura Y.
- Journal Title
  
  Clin.Exp.Immunol. 162(2)Epub 2010 Sep 1.
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249026
[Journal Article] TIM1 is an endogenous ligand for LMIR5/CD300b : LMIR5 deficiency ameliorates mouse kidney ischemia/reperfusion injury.2010
- Author(s)
  Yamanishi Y, Kitaura J, Izawa K, Kaitani A, Komeno Y, Nakamura M, Yamazaki S, Enomoto Y, Oki T, Akiba H, Abe T, Komori T, Morikawa Y, Kiyonari H, Takai T, Okumura K, Kitamura T.
- Journal Title
  
  J.Exp.Med. 207(7)Epub 2010 Jun 21.
  
  Pages: 1501-1511
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249026
[Journal Article] Genetic deletion of paired immunoglobulin-like receptor B does not promote axonal plasticity or functional recovery after traumatic brain injury.2010
- Author(s)
  Omoto S, Ueno M, Mochio S, Takai T, Yamashita T.
- Journal Title
  
  J.Neurosci. 30
  
  Pages: 13045-13052
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249026
[Journal Article] Genetic deletion of paired immunoglobulin-like receptor B does not promote axonal plasticity or functional recovery after traumatic brain injury2010
- Author(s)
  Omoto S, Ueno M, Mochio S, Takai T, Yamashita T
- Journal Title
  
  J. Neurosci
  
  Volume: 30 Pages: 13045-13052
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22659057
[Journal Article] TIM1 is an endogenous ligand for LMIR5/CD300b : LMIR5 deficiency ameliorates mouse kidney 1ischemia/reperfusion injury2010
- Author(s)
  Yamanishi Y, Kitaura J, Izawa K, Kaitani A, Komeno Y, Nakamura M, Yamazaki S, Enomoto Y, Oki T, Akiba H, Abe T, Komori T, Morikawa Y, Kiyonari H, Takai T, Okumura K, Kitamura T
- Journal Title
  
  J. Exp. Med
  
  Volume: 207(7) Pages: 1501-11
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22659057
[Journal Article] The study of allergy by Japanese researchers : a historical perspective. (Review)2009
- Author(s)
  Takai T, Karasuyama H
- Journal Title
  
  Int.Immu. 21(12)[Epub ahead of print]
  
  Pages: 1311-1316
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249026
[Journal Article] The study of allergy by Japanese researchers : a historical perspective2009
- Author(s)
  Takai T, et al.
- Journal Title
  
  Int.Immu. 21(12)
  
  Pages: 1311-1316
- NAID
  10027390623
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20060001
[Journal Article] Peroxiredoxin III-deficiency sensitizes macrophages to oxidative stress.2009
- Author(s)
  Li L, Kaifu T, Obinata M, Takai T.
- Journal Title
  
  J.Biochem. 145(4)
  
  Pages: 425-427
- NAID
  10026301912
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249026
[Journal Article] Ectopically expressed PIR-B on T cells constitutively binds to MHC class I and attenuates T helper type 1 responses.2009
- Author(s)
  Imada M, Masuda M, Satoh R, Ito Y, Goto Y, Matsuoka T, Endo S, Nakamura A, Kawamoto H, Takai T
- Journal Title
  
  Int.Immu. 21(10)
  
  Pages: 1151-1161
- NAID
  10027389800
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249026
[Journal Article] Augmented TLR9-induced Btk activation in PIR-B-deficient B-1 cells provokes excessive autoantibody production and autoimmunity.2009
- Author(s)
  Kubo T, Uchida Y, Watanabe Y, Abe M, Nakamura A, Ono M, Akira S, Takai T.
- Journal Title
  
  J.Exp.Med. 206
  
  Pages: 1971-1982
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249026
[Journal Article] The study of allergy by Japanese researchers : a historical perspective.2009
- Author(s)
  Takai T, et al.
- Journal Title
  
  Int.Immu. 21(12)
  
  Pages: 1311-1316
- NAID
  10027390623
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249026
[Journal Article] DAP12-independent Ly49H-mediated NK cell responses against mouse cytomegalovirus.2009
- Author(s)
  Orr MT, Sun JC, Hesslein DG, Arase H, Phillips JH, Takai T, Lanier LL.
- Journal Title
  
  J.Exp.Med. 206
  
  Pages: 807-817
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249026
[Journal Article] MCSF induces macrophage proliferatin and survival through a DAP12-beta-catenin signaling pathway.2009
- Author(s)
  Otero K, Turnbull IR, Poliani L, Vermi W, Aoshi T, Takai T, Stanley SL, Miller M, Colonna M.
- Journal Title
  
  Nat.Immunol. 10(7)
  
  Pages: 734-743
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249026
[Journal Article] Fc receptorγ-chain, a constitutive component of the interleukin-3 receptor, is required for interleukin 3-induced interleukin 4 production in basophils.2009
- Author(s)
  Hida S, Yamasaki S, Sakamoto Y, Takamoto M, Obata K, Takai T, Karasuyama H, Sugane K, Saito T, Taki S.
- Journal Title
  
  Nat.Immunol. 10(2)
  
  Pages: 214-222
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249026
[Journal Article] DAP10 associates with Ly49 receptors but contributes minimally to their expression and function in vivo.2009
- Author(s)
  Tassi I, Le Friec G, Gilfillan S, Takai T, Yokoyama WM, Colonna M.
- Journal Title
  
  Eur.J.Immunol. 39(4)
  
  Pages: 1129-1135
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249026
[Journal Article] Signal adaptor DAP10 associates with MDL-1 and triggers osteoclastogenesis in cooperation with DAP12.2009
- Author(s)
  Inui M, Kikuchi Y, Aoki N, Endo S, Maeda T, Sugahara-Tobinai A, Nakamura A, Kumanogoh A, Colonna M, Takai T.
- Journal Title
  
  Proc Natl Acad Sci USA. 106(12)
  
  Pages: 4816-4821
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249026
[Journal Article] Inhibitory immunoglobulin-like receptors LILRB and PIR-B negatively regulate osteoclast development.2008
- Author(s)
  Mori Y, Tsuji S, Inui M, Sakamoto Y, Endo S, Ito Y, Fujimura S, Koga T, Nakamura A, Takayanagi H, Itoi E, Takai T.
- Journal Title
  
  J.Immunol. 181(7)
  
  Pages: 4742-4751
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249026
[Journal Article] Analysis of mouse LMIR5/CLM7 as an activating receptor: differential regulation of LMIR5/CLM7 in ouse versus human cells.2008
- Author(s)
  Yamanishi Y, Kitaura J, Izawa K, Matsuoka T, Oki T, Lu Y, Shibata F, Yamazaki S, Kumagai H, Nakajima H, Maeda-Yamamoto M, Tybulewicz VLJ, Takai T, Kitamura T.
- Journal Title
  
  Blood 111
  
  Pages: 688-698
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249026
[Journal Article] Regulation of cytotoxic T lymphocyte triggering by PIR-B on dendritic cells.2008
- Author(s)
  Endo S, Sakamoto Y, Nakamura A, Takai T.
- Journal Title
  
  Proc.Natl.Acad.Sci.USA 105
  
  Pages: 14515-14520
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249026
[Journal Article] Tyrosine kinases Btk and Tec regulate osteoclast differentiation by linking RANK and ITAM signals.2008
- Author(s)
  Shinohara M, Koga T, Okamoto K, Sakaguchi S, Arai K, Yasuda H, Takai T, Kodama T, Morio T, Geha RS, Kitamura D, Kurosaki T, Ellmeier W, Takayanagi H.
- Journal Title
  
  Cell 132(5)
  
  Pages: 794-806
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249026
[Journal Article] Essential role of DAP12 signaling in macrophage programming into a fusion-competent state.2008
- Author(s)
  Helming L, Tomasello E, Kyriakides TR, Martinez FO, Takai T, Gordon S, Vivier E.
- Journal Title
  
  Sci Signal. 1(43)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249026
[Journal Article] A novel regulatory role of gp49B on dendritic cells in T cell priming.2008
- Author(s)
  Kasai S, Inui M, Nakamura K, Kakizaki Y, Endo S, Nakamura A, Ito S, Takai T.
- Journal Title
  
  Eur.J.Immunol. 38
  
  Pages: 2426-2437
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249026
[Journal Article] PIR-B-deficient mice are susceptible to Salmonella infection.2008
- Author(s)
  Torii I, Oka S, Hotomi M, Benjamin WH Jr, Takai T, Kearney JF, Briles DE, Kubagawa H.
- Journal Title
  
  J.Immunol. 181(6)
  
  Pages: 4229-4239
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249026
[Journal Article] Fcγ Receptor Regulation of Citrobacter rodentium Infection.2008
- Author(s)
  Masuda A, Yoshida M, Shiomi H, Ikezawa S, Takagawa T, Tanaka H, Chinzei R, Ishida T, Morita Y, Kutsumi H, Inokuchi H, Wang S, Kobayashi K, Mizuno S, Nakamura A, Takai T, Blumberg RS, Azuma T.
- Journal Title
  
  Infect.Immunity 76
  
  Pages: 1728-1737
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249026
[Journal Article] Comparison of 30 immunity-related genes from thecommon marmoset with orthologues from human and mouse.2008
- Author(s)
  Kohu K, Yamabe E, Matsuzawa A, Onda D, Suemizu H, Sasaki E, Tanioka Y, Yagita H, Suzuki D, Kametani Y, Takai T, Toyoda A, Habu S, Satake M.
- Journal Title
  
  Tohoku J.Exp.Med. 215
  
  Pages: 167-180
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249026
[Journal Article] Fc receptors: their diverse functions in immunity and immune disorders2006
- Author(s)
  Takai T.
- Journal Title
  
  Springer Semin Immunopathol (Review) Dec;28(4)
  
  Pages: 303-304
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17209017
[Journal Article] Fc receptors: their diverse functions in immunity and immune disorders2006
- Author(s)
  Takai T.
- Journal Title
  
  Springer Semin Immunopathol (Review) Dec 28(4)
  
  Pages: 303-304
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17209017
[Journal Article] A novel recognition system for MHC class I molecules constituted by PIR.2005
- Author(s)
  Takai T.
- Journal Title
  
  Adv.Immunol.(Review) 88
  
  Pages: 161-192
- Data Source
  KAKENHI-PROJECT-17659077
[Journal Article] Paired Immunoglobulin-like Receptors and their MHC class I recognition.2005
- Author(s)
  Takai T.
- Journal Title
  
  Immunology (Review) 115(4)
  
  Pages: 433-440
- Data Source
  KAKENHI-PROJECT-17659077
[Journal Article] The src family kinases Hck and Fgr negatively regulate neutrophil and dendritic cell chemokine signaling via PIR-B.2005
- Author(s)
  Zhang H, Meng F, Chu C-L, Takai T, Lowell C
- Journal Title
  
  Immunity 22
  
  Pages: 235-246
- Data Source
  KAKENHI-PROJECT-17209017
[Journal Article] Paired immunoglobulin-like Receptors and their MHC class I Recognition.2005
- Author(s)
  Takai T
- Journal Title
  
  immunology (Review) 115(4)
  
  Pages: 433-440
- Data Source
  KAKENHI-PROJECT-17209017
[Journal Article] Hydronephrosis associated with antiurothelial and antinuclear autontibodies in BALB/c-Fcgr2b-/-Pdcd1-/-mice.2005
- Author(s)
  Okazaki I, Otaka Y, Wang J, Hiai H, Takai T, Ravetch JV, Honjo T
- Journal Title
  
  J. Exp. Med. 202
  
  Pages: 1643-1648
- Data Source
  KAKENHI-PROJECT-17209017
[Journal Article] Pathways participating in activation of mouse uterine natural killer cells during pregnancy.2005
- Author(s)
  Xie X, He H, Colonna M, Seya T, Takai T, Croy BA
- Journal Title
  
  Biol Reprod 73(3)
  
  Pages: 510-518
- Data Source
  KAKENHI-PROJECT-17209017
[Journal Article] Paired Immunoglobulin-like Receptors and their MHC class I recognition2005
- Author(s)
  Takai T.
- Journal Title
  
  Immunology (Review) 115(4)
  
  Pages: 433-440
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17209017
[Journal Article] A novel recognition system for MHC class I molecules constituted by PIR.2005
- Author(s)
  Takai T
- Journal Title
  
  immunology (Review) 88
  
  Pages: 161-192
- Data Source
  KAKENHI-PROJECT-17209017
[Journal Article] Hydronephrosis associated with antiurothelial and antinuclear autoantibodies in BALB/c-Fcgr2b-/-Pdcd1-/- mice.2005
- Author(s)
  Okazaki T, Otaka Y, Wang J, Hiai H, Takai T, Ravetch JV, Honjo T.
- Journal Title
  
  J.Exp.Med. 202
  
  Pages: 1643-1648
- Data Source
  KAKENHI-PROJECT-17659077
[Journal Article] Pathways participating in activation of mouse uterine natural killer cells during pregnancy.2005
- Author(s)
  Xie X, He H, Colonna M, Seya T, Takai T, Croy BA.
- Journal Title
  
  Biol Reprod 73(3)
  
  Pages: 510-518
- Data Source
  KAKENHI-PROJECT-17659077
[Journal Article] Fc receptors and their role in immune regulation and autoimmunity2005
- Author(s)
  Takai T.
- Journal Title
  
  J. Clin. Immunol (Review) 25
  
  Pages: 1-18
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17209017
[Journal Article] A novel recognition system for MHC class I molecules constituted by PIR2005
- Author(s)
  Takai T.
- Journal Title
  
  Adv. Immunol (Review) 88
  
  Pages: 161-192
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17209017
[Journal Article] The src-family kinases Hck and Fgr negatively regulate neutrophil and dendritic cell chemokine signaling via PIR-B.2005
- Author(s)
  Zhang H, Meng F, Chu C-L, Takai T, Lowell C.
- Journal Title
  
  Immunity 22
  
  Pages: 235-246
- Data Source
  KAKENHI-PROJECT-17659077
[Journal Article] DAP12 (KARAP) amplifies inflammation and increases mortality from endotoxemia and septic peritonitis.2005
- Author(s)
  Turnbull R, McDunn JE, Takai T, Townsend RR, Cobb JP, Colonna M
- Journal Title
  
  J. Exp. Med. 202(3)
  
  Pages: 363-369
- Data Source
  KAKENHI-PROJECT-17209017
[Journal Article] DAP12 (KARAP) amplifies inflammation and increases mortality from endotoxemia and septic peritonitis.2005
- Author(s)
  Tumbull IR, McDunn JE, Takai T, Townsend RR, Cobb JP, Colonna M.
- Journal Title
  
  J.Exp.Med. 202(3)
  
  Pages: 363-369
- Data Source
  KAKENHI-PROJECT-17659077
[Journal Article] Immortalized dendritic cell line with efficient cross-priming ability established from transgenic mice harboring the temperature-sensitive SV40 large T-antigen gene.2004
- Author(s)
  Ebihara S, Endo S, Ito K, Ito Y, Akiyama K, Obinata M, Takai T
- Journal Title
  
  J.Biochem. 136
  
  Pages: 321-328
- NAID
  10016202020
- Data Source
  KAKENHI-PROJECT-14207014
[Journal Article] The inhibitory receptor PIR-B negatively regulates neutrophil and macrophage integrin signaling.2004
- Author(s)
  Pereira S, Zhang H, Takai T, Lowell CA.
- Journal Title
  
  J.Immunol. 173(9)
  
  Pages: 5757-5765
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14207014
[Journal Article] Exacerbated graft-versus-host disease in Pirb-/-mice.2004
- Author(s)
  Nakamura A, Kobayashi E, Takai T.
- Journal Title
  
  Nature Immunol. (Published online : 16 May 2004) 5(6)
  
  Pages: 623-629
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14207014
[Journal Article] Possible role of autoantibody in the pathophysiology of GM2 angliosidoses.2004
- Author(s)
  Yamaguchi, A., Katsuyama, K., Nagahama, K., Takai, T., Aoki, I., Yamanaka, S.
- Journal Title
  
  J.Clin.Invest. 113
  
  Pages: 200-208
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14207014
[Journal Article] Exacerbated graft-versus-host disease in Pirb-/- mice.2004
- Author(s)
  Nakamura A, Kobayashi E, Takai T
- Journal Title
  
  Nature Immunol. 5(6)
  
  Pages: 623-629
- Data Source
  KAKENHI-PROJECT-14207014
[Journal Article] Immortalized dendritic cell line with efficient cross-priming ability established from transgenic mice harboring the temperature-sensitive SV40 large T-antigen gene.2004
- Author(s)
  Ebihara S, Endo S, Ito K, Ito Y, Akiyama K, Obinata M, Takai T.
- Journal Title
  
  J.Biochem. 136
  
  Pages: 321-328
- NAID
  10016202020
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14207014
[Journal Article] Costimulatory signals mediated by the ITAM motif cooperate with RANKL for bone homeostasis.2004
- Author(s)
  Koga T*, Inui M*, Inoue K, Kim S, Suematsu A, Kobayashi E, Iwata T, Ohnishi H, Matozaki T, Kodama T, Taniguchi T, Takayanagi H, Takai T (*equal contributor)
- Journal Title
  
  Nature 428
  
  Pages: 758-763
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14207014
[Journal Article] The inhibitory receptor PIR-B negatively regulates neutrophil and macrophage integrin signaling.2004
- Author(s)
  Pereira S, Zhang H, Takai T, Lowell CA
- Journal Title
  
  J.Immunol. 173(9)
  
  Pages: 5757-5765
- Data Source
  KAKENHI-PROJECT-14207014
[Journal Article] Roles of Fcγ RIIB in nasal eosinophilia and IgE production in murine allergic rhinitis.2004
- Author(s)
  Watanabe, T., Okano, M., Hattori, H., Yoshino, T., Ohno, N., Ohta, N., Sugata, Y., Orita, Y., Takai, T., Nishizaki, K.
- Journal Title
  
  Am.J.Respir.Crit.Care Med. (Epub ahead of print, Oct.2,2003) 169
  
  Pages: 105-112
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14207014
[Journal Article] Exacerbated graft-versus-host disease in Pirb-/- mice.2004
- Author(s)
  Nakamura A, Kobayashi E, Takai T.
- Journal Title
  
  Nature Immunol. 5(6)
  
  Pages: 623-629
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14207014
[Journal Article] Contribution of Fcγ receptors to antigen presentation and elicitation of humoral response in vivo.2003
- Author(s)
  Yada, A., Ebihara, S., Matsumura, K., Akiyama, K., Aiba, S., Takai, T.
- Journal Title
  
  Cell.Immunol. 225(1)
  
  Pages: 21-32
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14207014
[Journal Article] Signaling via immunoglobulin Fc receptors induces oligodendrocyte precursor cell differentiation.2003
- Author(s)
  Nakahara, J., Tan-Takeuchi, K., Seiwa, C, Gotoh, M., Kaifu, T., Ujike, A., Inui, M., Yagi, T., Aiso, S., Takai, T., Asou, H.
- Journal Title
  
  Dev.Cell 4(6)
  
  Pages: 841-852
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14207014
[Journal Article] Deregulation of peripheral B cell development in enhanced severity of collagen-induced arthritis in Fcγ RIIB-deficient mice.2003
- Author(s)
  Nakamura, A., Nukiwa, T., Takai, T.
- Journal Title
  
  J.Autoimmu. 20
  
  Pages: 227-236
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14207014
[Journal Article] Increased susceptibility to LPS-induced endotoxin shock in secretory leukoprotease inhibitor (SLPI)-deficient mice.2003
- Author(s)
  Nakamura, A., Mori, Y., Hagiwara, K., Suzuki, T., Sakakibara, T., Kikuchi, T., Igarashi, T., Ebina, M., Miyazaki, J., Takai, T., Nukiwa, T.
- Journal Title
  
  J.Exp.Med. 197
  
  Pages: 669-674
- NAID
  120004898439
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14207014
[Journal Article] Osteopetrosis and thalamic hypomyelinosis with synaptic degeneration in DAP12-deficient mice.2003
- Author(s)
  Kaifu, T.*, Nakahara, J.*, Inui, M.*, Mishima, K., Momiyama, T., Kaji, M., Sugahara, A., Koito, H., Ujike-Asai, A., Nakamura, A., Kanazawa, K., Tan-Takeuchi, K., Iwasaki, K., Yokoyama, W.M., Kudo, A., Fujiwara, M., Asou, H., Takai, T.(*equal contributor)
- Journal Title
  
  J.Clin.Invest. 111(3)
  
  Pages: 323-332
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14207014
[Journal Article] Targeting of platelet integrin αIIbβ3 determines systemic reaction and bleeding in murine thrombocytopenia regulated by activating and inhibitory FcgRs2003
- Author(s)
  Nieswandt, B., Bergmeier, W., Schulte, V., Takai, T., Baumann, U., Schmidt, R.E., Zirngibl, H., Bloch, W, Gessner, J.E.
- Journal Title
  
  Int.Immunol. 15
  
  Pages: 341-349
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14207014
[Journal Article] Fc receptors as potential targets for treatment of allergy, autoimmune disease and cancer.2003
- Author(s)
  Takai, T., Nakamura, A., Akiyama, K.
- Journal Title
  
  Current Drug Target5-Immune, Endocrine & Metabolic Disorders.(Review) 3
  
  Pages: 187-197
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14207014
[Journal Article] FcgRIIB deficiency with Fas mutation is sufficient for the development of systemic autoimmune disease.2003
- Author(s)
  Yajima K, Nakamura A, Sugahara A, Takai T.
- Journal Title
  
  Eur.J.Immunol. 33
  
  Pages: 1020-1029
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14207014
[Journal Article] Transient neutrophil inflammation after allergen challenge is dependent on specific antibodies and Fc receptors.2003
- Author(s)
  Taube C, Takeda K, Dakhama A, Rha Y, Joetham A, Park J.-W, Ballhorn A, Takai T, Benchich KR, Nick JA, Gelfand EW.
- Journal Title
  
  J.Immunol. 170
  
  Pages: 4301-4309
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14207014
[Journal Article] Contribution of Fc γ receptors to antigen presentation and elicitation of humeral response in vivo.2003
- Author(s)
  Yada, A., Ebihara, S., Matsumura, K., Akiyama, K., Aiba, S., Takai, T.
- Journal Title
  
  Cell.Immunol. 225(1)
  
  Pages: 21-32
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14207014
[Journal Article] Targeting of apoptotic tumor cells to Fcγ receptors provides efficient and versatile vaccination against tumors by dendritic cells.2003
- Author(s)
  Akiyama K, Ebihara S, Yada, A., Matsumura, K., Aiba, S., Nukiwa, T., Takai, T.
- Journal Title
  
  J.Immunol. 170(4)
  
  Pages: 1641-1648
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14207014
[Journal Article] Targeting of apoptotic tumor cells to Fcγ receptors provides efficient and versatile vaccination against tumors by dendritic cells.2003
- Author(s)
  Akiyama K, Ebihara S, Yada, A., Matsumura, K., Aiba, S., Nukiwa, T., Takai T.
- Journal Title
  
  J.Immunol. 170(4)
  
  Pages: 1641-1648
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14207014
[Journal Article] Fc receptors as potential targets for treatment of allergy, autoimmune disease and cancer.2003
- Author(s)
  Takai, T., Nakamura, A., Akiyama, K.
- Journal Title
  
  Current Drug Targets-Immune, Endocrine & Metabolic Disorders. 3
  
  Pages: 187-197
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14207014
[Journal Article] Deregulation of peripheral B cell development in enhanced severity of collagen-induced arthritis in FcγRIIB-deficient mice.2003
- Author(s)
  Nakamura, A., Nukiwa, T., Takai, T.
- Journal Title
  
  J.Autoimmu. 20
  
  Pages: 227-236
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14207014
[Journal Article] The pre-B cell receptor signaling for apoptosis is negatively regulated by FcgRIIB.2002
- Author(s)
  Kato I, Takai T, Kudo A.
- Journal Title
  
  J.Immunol. 168
  
  Pages: 629-634
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14207014
[Journal Article] Roles of Fc receptors in autoimmunity.2002
- Author(s)
  Takai T.
- Journal Title
  
  Nature Rev.Immunol. 2
  
  Pages: 580-592
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14207014
[Journal Article] Impaired dendritic cell maturation and increased TH2 responses in PIR-B-/- mice.2002
- Author(s)
  Ujike, A., Takeda, K., Nakamura, A., Ebihara, S., Akiyama, K., Takai, T.
- Journal Title
  
  Nature Immunol. 3
  
  Pages: 542-548
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14207014
[Journal Article] Impaired dendritic cell maturation and increased TH2 responses in PIR-B-/-mice.2002
- Author(s)
  Ujike, A., Takeda, K., Nakamura, A., Ebihara, S., Akiyama, K., Takai, T.
- Journal Title
  
  Nature Immunol. 3
  
  Pages: 542-548
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14207014
[Journal Article] The control effect of histamine on the body temperature and respiratory function in IgE-dependent systemic anaphylaxis.2002
- Author(s)
  Makabe-Kobayashi Y, Hori Y, Adachi T, Ishigaki-Suzuki S, Kikuchi Y, Kagaya Y, Shirato K, Nagy A, Ujike A, Takai T, Watanabe T, Ohtsu H.
- Journal Title
  
  J.Allergy Clin.Immunol. 110
  
  Pages: 298-303
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14207014
[Patent] 抗ヒト免疫抑制性受容体ＬＩＬＲＢ４モノクローナル抗体又はその抗体断片，免疫チェックポイント阻害剤，免疫チェックポイント関連疾患の治療剤及びヒト免疫抑制性受容体ＬＩＬＲＢ４の測定方法2021
- Inventor(s)
  高井俊行，蘇美慈，遠藤章太
- Industrial Property Rights Holder
  東北大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2021-048355
- Filing Date
  2021
- Data Source
  KAKENHI-PROJECT-19H03484
[Patent] 免疫チェックポイントB4-B4L1阻害剤，当該免疫チェックポイント関連疾患（がんや自己免疫疾患など）の治療剤，（中略）及びB4L1またはその部分タンパク質を検出する方法2020
- Inventor(s)
  高井俊行，乾匡範，蘇美慈，遠藤章太
- Industrial Property Rights Holder
  東北大学
- Industrial Property Rights Type
  特許
- Filing Date
  2020
- Overseas
- Data Source
  KAKENHI-PROJECT-19H03484
[Patent] 免疫チェックポイントB4-B4リガンド（B4L1）阻害剤，当該免疫チェックポイント関連疾患（がんや自己免疫疾患など）の治療剤，（中略）及びB4L1またはその部分タンパク質を検出する方法2019
- Inventor(s)
  高井俊行，乾　匡範，蘇　美慈，遠藤章太
- Industrial Property Rights Holder
  高井俊行，乾　匡範，蘇　美慈，遠藤章太
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2019-148423
- Filing Date
  2019
- Data Source
  KAKENHI-PROJECT-17K19539
[Patent] 免疫チェックポイントB4-B4リガンド（B4L1）阻害剤，当該免疫チェックポイント関連疾患（がんや自己免疫疾患など）の治療剤，（中略）及びB4L1またはその部分タンパク質を検出する方法2019
- Inventor(s)
  高井俊行，乾　匡範，蘇　美慈，遠藤章太
- Industrial Property Rights Holder
  高井俊行，乾　匡範，蘇　美慈，遠藤章太
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2019-148423
- Filing Date
  2019
- Data Source
  KAKENHI-PROJECT-19H03484
[Patent] 炎症性疾患のマーカー2016
- Inventor(s)
  高井俊行，石井智徳，藤井博司，乾　匡範
- Industrial Property Rights Holder
  高井俊行，石井智徳，藤井博司，乾　匡範
- Industrial Property Rights Type
  特許
- Filing Date
  2016-07-29
- Data Source
  KAKENHI-PROJECT-16H05201
[Presentation] 川崎病患者に対する免疫グロブリン大量療法前後における抑制性受容体LILRB発現の変化について.2016
- Author(s)
  久間木悟、乾匡範、飛内章子、三浦舞子、目時嵩也、渡邊庸平、大沼良一、野口理恵、貴田岡節子、高井俊行.
- Organizer
  第36回日本川崎病学会
- Place of Presentation
  横浜
- Year and Date
  2016-10-01
- Data Source
  KAKENHI-PROJECT-26461597
[Presentation] Expression of gp49B on plasma cells from autoimmune-prone mice and its relevance to progression of autoimmune disease.2016
- Author(s)
  Wong YiLi、Inui M、Takai T
- Organizer
  第45回日本免疫学会学術集会
- Place of Presentation
  沖縄コンベンションセンター（沖縄・宜野湾）
- Year and Date
  2016-12-06
- Data Source
  KAKENHI-PROJECT-16H05201
[Presentation] Nogo positively regulates TLR signal pathway and inflammatory gene expression in macrophages2013
- Author(s)
  Kimura T,Inui M,Takai T.
- Organizer
  Frontiers in Immunology and Inflammation : From Molecules to Disease
- Place of Presentation
  Tokyo
- Data Source
  KAKENHI-PROJECT-24659215
[Presentation] Negative regulation of autoantibody production by a B cell inhibitory receptor FcγRIIB2013
- Author(s)
  Toshiyuki Takai,Yasuyoshi Kanari,Akiko Sugahara-Tobinai
- Organizer
  NIH-Tohoku University-JSPS Symposium
- Place of Presentation
  Gonryo Hall,Sendai
- Data Source
  KAKENHI-PROJECT-24659215
[Presentation] Regulation of TLR signaling by a reticulon family protein Nogo in macrophages2012
- Author(s)
  Kimura T,Inui M,Takai T.
- Organizer
  The Annual Meeting of the japanese Society for Immunology
- Place of Presentation
  Kobe
- Year and Date
  2012-12-05
- Data Source
  KAKENHI-PROJECT-24659215
[Presentation] Negative Regulation of Autoantibody Production by a B Cell Inhibitory Receptor,FcgRIIB,Centennial of Hashimoto Disease Symposium2012
- Author(s)
  Toshiyuki Takai
- Organizer
  International Symposium II : Autoimmune Diseases-Etiology and Therapeutics
- Place of Presentation
  ACROS Fukuoka
- Year and Date
  2012-12-03
- Data Source
  KAKENHI-PROJECT-24659215
[Presentation] Regulatory effects of IgG on B cell functions2012
- Author(s)
  高井俊行
- Organizer
  RCAI Workshop
- Place of Presentation
  RCAI, Yokohama
- Year and Date
  2012-03-23
- Data Source
  KAKENHI-PROJECT-22659057
[Presentation] Update understanding of the mechanism of action of IVIG2012
- Author(s)
  Toshiyuki Takai
- Organizer
  10th Kawasaki Disease Symposium
- Place of Presentation
  Kyoto
- Year and Date
  2012-02-08
- Data Source
  KAKENHI-PROJECT-22659057
[Presentation] Update understanding of the mechanism of action of IVIG2012
- Author(s)
  Toshiyuki Takai
- Organizer
  10^<th> Kawasaki Disease Symposium
- Place of Presentation
  京都(招待講演)
- Year and Date
  2012-02-08
- Data Source
  KAKENHI-PUBLICLY-22021004
[Presentation] Update understanding of the mechanism of action of IVIG2012
- Author(s)
  Toshiyuki Takai
- Organizer
  10^<th> Kawasaki Disease Symposium
- Place of Presentation
  京都(招待講演)
- Year and Date
  2012-02-08
- Data Source
  KAKENHI-PROJECT-22659057
[Presentation] Regulation of TLR9 and autoimmunity by PirB, a multiligand inhibitory receptor2011
- Author(s)
  Toshiyuki Takai
- Organizer
  Second CSI/JSI/KAI Joint Symposium on Immunology
- Place of Presentation
  大阪(招待講演)
- Year and Date
  2011-12-06
- Data Source
  KAKENHI-PUBLICLY-22021004
[Presentation] Intravenous Immunoglobulin inhibits autoantibody production by B-1 cells2011
- Author(s)
  Tanaka J, Nakano A, Itoh Y and Takai T
- Organizer
  10th World Congress on Inflammation
- Place of Presentation
  Paris, France
- Year and Date
  2011-06-26
- Data Source
  KAKENHI-PROJECT-22659057
[Presentation] 免疫制御受容体PIR-Bによる自己免疫の制御2011
- Author(s)
  高井俊行
- Organizer
  第2回愛媛大学プロテオ医学研究センターシンポジウム(招待講演)
- Place of Presentation
  愛媛
- Year and Date
  2011-02-06
- Data Source
  KAKENHI-PROJECT-20249026
[Presentation] 抗体療法とFcレセプター2011
- Author(s)
  高井俊行
- Organizer
  第31回日本川崎病学会・学術集会ランチョンセミナー2
- Place of Presentation
  はまぎんホール・ヴィアマーレ横浜市
- Year and Date
  2011-10-01
- Data Source
  KAKENHI-PROJECT-22659057
[Presentation] Regulation of TLR9 and autoimmunity by PirB, a multiligand inhibitory receptor2011
- Author(s)
  Toshiyuki Takai
- Organizer
  Second CSI/JSI/KAI Joint Symposium on Immunology
- Place of Presentation
  大阪(招待講演)
- Year and Date
  2011-12-06
- Data Source
  KAKENHI-PROJECT-22659057
[Presentation] NogoおよびMHCクラスIによるPIR-Bへの競合的結合によるマスト細胞の制御について2011
- Author(s)
  篠崎夏子, 乾匡範, 遠藤章太, 坂本譲, 北口公司, 高井俊行
- Organizer
  第61回日本アレルギー学会秋季学術大会
- Place of Presentation
  東京
- Year and Date
  2011-11-11
- Data Source
  KAKENHI-PROJECT-22659057
[Presentation] Fcγ receptor targeting-How ITIM receptors regulate2011
- Author(s)
  Toshiyuki Takai
- Organizer
  Bio-Rheumatology International Congress (BRIC)
- Place of Presentation
  幕張(招待講演)
- Year and Date
  2011-11-15
- Data Source
  KAKENHI-PUBLICLY-22021004
[Presentation] Targeting Fc receptors2011
- Author(s)
  Toshiyuki Takai
- Organizer
  第32回日本炎症・再生医学会
- Place of Presentation
  京都(招待講演)
- Year and Date
  2011-06-02
- Data Source
  KAKENHI-PUBLICLY-22021004
[Presentation] 抗体療法とFcレセプター2011
- Author(s)
  高井俊行
- Organizer
  第31回日本川崎病学会・学術集会
- Place of Presentation
  横浜(招待講演)
- Year and Date
  2011-10-01
- Data Source
  KAKENHI-PUBLICLY-22021004
[Presentation] Fc受容体と免疫疾患について2011
- Author(s)
  高井俊行
- Organizer
  第16回シェーグレン症候群セミナー特別講演
- Place of Presentation
  東京(招待講演)
- Year and Date
  2011-06-04
- Data Source
  KAKENHI-PROJECT-22659057
[Presentation] Fcγ receptor targeting-How ITIM receptors regulate2011
- Author(s)
  Toshiyuki Takai
- Organizer
  Bio-Rheumatology International Congress (BRIC)
- Place of Presentation
  幕張(招待講演)
- Year and Date
  2011-11-15
- Data Source
  KAKENHI-PROJECT-22659057
[Presentation] NogoおよびMHC class IによるPIR-Bを介した新たなマスト細胞の制御機構2011
- Author(s)
  乾匡範, 篠崎夏子, 遠藤章太, 高井俊行
- Organizer
  第61回日本アレルギー学会秋季学術大会
- Place of Presentation
  東京
- Year and Date
  2011-11-11
- Data Source
  KAKENHI-PROJECT-22659057
[Presentation] 制御性受容体PIR-Bによる自己免疫の制御2011
- Author(s)
  高井俊行
- Organizer
  愛媛大学プロテオ医学研究センター学術シンポジウム
- Place of Presentation
  愛媛県松山市
- Year and Date
  2011-02-06
- Data Source
  KAKENHI-PUBLICLY-22021004
[Presentation] Fc受容体と免疫疾患について2011
- Author(s)
  高井俊行
- Organizer
  第16回シェーグレン症候群セミナー
- Place of Presentation
  東京
- Year and Date
  2011-06-04
- Data Source
  KAKENHI-PROJECT-22659057
[Presentation] 制御性受容体PIR・Bによる自己免疫の制御2011
- Author(s)
  高井俊行
- Organizer
  愛媛大学プロテオ医学研究センター学術シンボジウム
- Place of Presentation
  愛媛県松山市
- Year and Date
  2011-02-06
- Data Source
  KAKENHI-PROJECT-20249026
[Presentation] 静注用免疫グロブリンはB-1細胞からの自己抗体産生を抑制する2011
- Author(s)
  田中純, 仲野篤史, 伊藤由美, 高井俊行
- Organizer
  第32回日本炎症・再生医学会
- Place of Presentation
  京都
- Year and Date
  2011-06-03
- Data Source
  KAKENHI-PROJECT-22659057
[Presentation] 制御性受容体PIR・Bによる自己免疫の制御2011
- Author(s)
  高井俊行
- Organizer
  愛媛大学プロテオ医学研究センター学術シンポジウム
- Place of Presentation
  愛媛県松山市
- Year and Date
  2011-02-06
- Data Source
  KAKENHI-PROJECT-22659057
[Presentation] Targeting Fc receptors2011
- Author(s)
  Toshiyuki Takai
- Organizer
  第32回日本炎症・再生医学会
- Place of Presentation
  京都
- Year and Date
  2011-06-02
- Data Source
  KAKENHI-PROJECT-22659057
[Presentation] Targeting Fc receptors2011
- Author(s)
  Toshiyuki Takai
- Organizer
  第32回日本炎症・再生医学会
- Place of Presentation
  京都(招待講演)
- Year and Date
  2011-06-02
- Data Source
  KAKENHI-PROJECT-22659057
[Presentation] Fcγ receptor targeting . How ITIM receptors regulate2011
- Author(s)
  Toshiyuki Takai
- Organizer
  Bio-Rheumatology International Congress (BRIC)Tokyo/The 8th GARN Meeting Locomotor Science 1 . Recent Topics of RA
- Place of Presentation
  Hilton Tokyo Bay Hotel
- Year and Date
  2011-11-15
- Data Source
  KAKENHI-PROJECT-22659057
[Presentation] 抗体療法とFcレセプター2011
- Author(s)
  高井俊行
- Organizer
  第31回日本川崎病学会・学術集会
- Place of Presentation
  横浜(招待講演)
- Year and Date
  2011-10-01
- Data Source
  KAKENHI-PROJECT-22659057
[Presentation] Differential but competitive binding of Nogo and MHC class I to PIR-B regulates LPS-activated mast cells2011
- Author(s)
  Shinozaki N, Inui M, Endo S, Sakamoto Y, Kitaguchi K, Kuroki K, Maenaka K, Takai T
- Organizer
  2011 The annual meeting of the Japanese society for immunology
- Place of Presentation
  Chiba
- Year and Date
  2011-11-29
- Data Source
  KAKENHI-PROJECT-22659057
[Presentation] Transcriptional activation of the PIR-B gene in B cells by PU. 1 and Runx32011
- Author(s)
  Kitaguchi K, Arita K, Endo S, Kaifu T, Nakamura A, Takai T
- Organizer
  2011 The annual meeting of the Japanese society for immunology
- Place of Presentation
  Chiba
- Year and Date
  2011-11-28
- Data Source
  KAKENHI-PROJECT-22659057
[Presentation] A suppressive effect of IVIg on B1 cell activation and production of natural antibodies2011
- Author(s)
  Hirano K, Tanaka J, Sakamoto Y, Looi CY, Nakano A, Itoh Y, Takai T
- Organizer
  The annual meeting of the Japanese society for immunology
- Place of Presentation
  Chiba
- Year and Date
  2011-11-27
- Data Source
  KAKENHI-PROJECT-22659057
[Presentation] Regulation of TLR9 and autoimmunity by PirB, a multiligand inhibitory receptor2011
- Author(s)
  Toshiyuki Takai
- Organizer
  Second CSI/JSI/KAI Joint Symposium on Immunology"Regulation of Immune Responses in Health and Diseases
- Place of Presentation
  Osaka
- Year and Date
  2011-12-06
- Data Source
  KAKENHI-PROJECT-22659057
[Presentation] Fc受容体と免疫疾患について2011
- Author(s)
  高井俊行
- Organizer
  第16回シェーグレン症候群セミナー特別講演
- Place of Presentation
  東京(招待講演)
- Year and Date
  2011-06-04
- Data Source
  KAKENHI-PUBLICLY-22021004
[Presentation] Regulation of TLR9 activation and autoantibody production in B-1 cells by PIR-B, an MHC class I receptor.2010
- Author(s)
  高井俊行
- Organizer
  8th German-Japanese Symposium.
- Place of Presentation
  Cuxhaven, Germany
- Year and Date
  2010-09-30
- Data Source
  KAKENHI-PUBLICLY-22021004
[Presentation] Regulation of TLR9 activation and autoantibody production in B-1 cells by PIR-B, an MHC class I receptor2010
- Author(s)
  高井俊行
- Organizer
  8th German-Japanese Symposium.
- Place of Presentation
  Cuxhaven, Germany
- Year and Date
  2010-09-28
- Data Source
  KAKENHI-PROJECT-22659057
[Presentation] 自己免疫疾患におけるIVIG療法の作用機序の最新知見2010
- Author(s)
  高井俊行
- Organizer
  献血ベニロン-I発売30周年記念講演会(招待講演)
- Place of Presentation
  ヒルトンホテル大阪大阪
- Year and Date
  2010-06-19
- Data Source
  KAKENHI-PROJECT-20249026
[Presentation] Regulation of autoimmunity by PIR-B.2010
- Author(s)
  高井俊行
- Organizer
  Asian Aging Core for Longevity 2010
- Place of Presentation
  Jeju Island, Korea
- Year and Date
  2010-08-25
- Data Source
  KAKENHI-PUBLICLY-22021004
[Presentation] 自己免疫疾患におけるIVIG療法の作用機序の最新知見2010
- Author(s)
  高井俊行
- Organizer
  献血ベニロン-I発売30周年記念講演会(招待講演)
- Place of Presentation
  帝国ホテル東京
- Year and Date
  2010-07-10
- Data Source
  KAKENHI-PROJECT-20249026
[Presentation] A regulatory role of PIR-B in plasmacytoid dendritic cells2010
- Author(s)
  Y.Mitsuhashi, A.Nakamura, T.Nukiwa, T.Takai.
- Organizer
  14th International Congress of Immunology (Kobe)(ポスター発表[PP-095-15])
- Year and Date
  2010-08-25
- Data Source
  KAKENHI-PROJECT-20249026
[Presentation] Regulation of autoimmunity by PIR-B.2010
- Author(s)
  高井俊行
- Organizer
  Asian Aging Core for Longevity 2010
- Place of Presentation
  Jeju island,Korea
- Year and Date
  2010-08-25
- Data Source
  KAKENHI-PROJECT-22659057
[Presentation] 抑制性受容体による免疫制御機構の解析2010
- Author(s)
  高井俊行
- Organizer
  日本薬学会第130年会(招待講演)
- Place of Presentation
  岡山
- Year and Date
  2010-03-28
- Data Source
  KAKENHI-PROJECT-20249026
[Presentation]2010
- Author(s)
  高井俊行
- Organizer
  免疫制御受容体による自己抗体の産生制御(招待講演)株式会社ベネシス
- Place of Presentation
  大阪
- Year and Date
  2010-12-13
- Data Source
  KAKENHI-PROJECT-20249026
[Presentation] A regulatory role of PIR-B in plasmacytoid dendritic cells2010
- Author(s)
  Nakamura A, Mitsuhashi M, Takai T
- Organizer
  The 5th International Symposium of Institute Network
- Place of Presentation
  Kanazawa
- Year and Date
  2010-06-24
- Data Source
  KAKENHI-PROJECT-20249026
[Presentation] (Invited) : Regulation of TLR9 activation and autoantibody production in B-1 cells by PIR-B, an MHC class I receptor.2010
- Author(s)
  高井俊行
- Organizer
  8th German-Japanese Symposium.
- Place of Presentation
  Hotel Strandperle, Cuxhaven, Germany
- Data Source
  KAKENHI-PROJECT-20249026
[Presentation] Kinetic analysis of the association between PIR-B and its related molecules in B cells.2010
- Author(s)
  Y.Sakamoto, Y.Watanabe, A.Nakamura, T.Takai.
- Organizer
  14th International Congress of Immunology (Kobe)(ポスター発表[PP-052-15])
- Year and Date
  2010-08-25
- Data Source
  KAKENHI-PROJECT-20249026
[Presentation] Regulation of TLR9 activation and autoantibody production in B-1 cells by PIR-B, an MHC class I receptor.2010
- Author(s)
  高井俊行
- Organizer
  8th German-Japanese Symposium.
- Place of Presentation
  Cuxhaven, Germany
- Year and Date
  2010-09-28
- Data Source
  KAKENHI-PROJECT-20249026
[Presentation] (Invited) : Regulation of autoimmunity by PIR-B.2010
- Author(s)
  高井俊行
- Organizer
  Asian Aging Core for Longevity, 2010
- Place of Presentation
  Neighborhood Hotel in Jeju, Jeju Island, Korea
- Data Source
  KAKENHI-PROJECT-20249026
[Presentation] Regulation of autoimmunity by PIR-B.2010
- Author(s)
  高井俊行
- Organizer
  Asian Aging Core for Longevity 2010
- Place of Presentation
  Jeju Island, Korea
- Year and Date
  2010-08-25
- Data Source
  KAKENHI-PROJECT-20249026
[Presentation] Regulation of cytotoxic T lymphocyte triggering by PIR-B on dendritic cells.2009
- Author(s)
  高井俊行
- Organizer
  2009 4th Medical Biotech Forum
- Place of Presentation
  Dalian, China
- Year and Date
  2009-08-10
- Data Source
  KAKENHI-PROJECT-20249026
[Presentation] (Invited Speaker and Chair of the session Track 6-3) : Regulation of cytotoxic T lymphocyte triggering by PIR-B on dendritic cells.2009
- Author(s)
  高井俊行
- Organizer
  In : Tumor Immunology and Immunotherapy. 2009 4th Medical Biotech Forum
- Place of Presentation
  Dalian, China
- Year and Date
  2009-08-10
- Data Source
  KAKENHI-PROJECT-20249026
[Presentation] Augmented TLR9-induced Btk activation in PIR-B-deficient B-1 cells provokes excessive rheumatoid factor production and autoimmunity.2009
- Author(s)
  高井俊行
- Organizer
  BIT's Life Sciences' 2nd Annual Protein and Peptide Conference(PepCon 2009)
- Place of Presentation
  Seoul, South Korea
- Year and Date
  2009-04-03
- Data Source
  KAKENHI-PROJECT-20249026
[Presentation] 免疫抑制性レセプターPIR-Bによるアレルギー制御2009
- Author(s)
  高井俊行, 中村晃
- Organizer
  第59回日本アレルギー学会秋季学術大会
- Place of Presentation
  秋田市
- Year and Date
  2009-10-29
- Data Source
  KAKENHI-PROJECT-20249026
[Presentation] Rheumatoid Factor(RF)Production Is Regulated by PIR-B on B-1 Cells and its Excessive Elevation Can Link to Autoimmunity.2009
- Author(s)
  高井俊行
- Organizer
  BIT's 1^<st> Annual International Congress of Antibody-2009
- Place of Presentation
  Beijing, China
- Year and Date
  2009-05-22
- Data Source
  KAKENHI-PROJECT-20249026
[Presentation] Regulation of cytotoxic T lymphocyte triggering by PIR-B on dendritic cells2009
- Author(s)
  高井俊行
- Organizer
  2009 4th Medical Biotech Forum
- Place of Presentation
  Dalian, China
- Year and Date
  2009-08-10
- Data Source
  KAKENHI-PROJECT-20060001
[Presentation] Rheumatoid Factor (RF) Production Is Regulated by PIR-B on B-1 Cells and its Excessive Elevation Can Link to Autoimmunity.2009
- Author(s)
  Toshiyuki Takai, Tomohiro Kubo, Yuki Uchida, Yuko Watanabe, Masahiro Abe, Akira Nakamura
- Organizer
  BIT's I^<st> Annual International Congress of Antibody-2009
- Place of Presentation
  Beijing, China
- Year and Date
  2009-05-22
- Data Source
  KAKENHI-PROJECT-20249026
[Presentation] Rheumatoid Factor(RF)Production Is Regulated by PIR-B on B-1 Cells and its Excessive Elevation Can Link to Autoimmunity2009
- Author(s)
  高井俊行
- Organizer
  BIT's 1^<st> Annual International Congress of Antibody-2009
- Place of Presentation
  Beijing, China
- Year and Date
  2009-05-22
- Data Source
  KAKENHI-PROJECT-20060001
[Presentation] Augmented TLR9-induced Btk activation in PIR-B-deficient B-1 cells provokes excessive rheumatoid factor production and autoimmunity.2009
- Author(s)
  高井俊行
- Organizer
  BIT's Life Sciences' 2nd Annual Protein and Peptide Conference (PepCon 2009))
- Place of Presentation
  Seoul, South Korea
- Year and Date
  2009-04-03
- Data Source
  KAKENHI-PROJECT-20249026
[Presentation] Augmented TLR9-induced Btk activation in PIR-B-deficient B-1 cells provokes excessive rheumatoid factor production and autoimmunity2009
- Author(s)
  高井俊行
- Organizer
  BIT's Life Sciences' 2nd Annual Protein and Peptide Conference(PepCon 2009)
- Place of Presentation
  Seoul, South Korea
- Year and Date
  2009-04-03
- Data Source
  KAKENHI-PROJECT-20060001
[Presentation] 免疫抑制性レセプターPIR-Bによるアレルギー制御2009
- Author(s)
  高井俊行
- Organizer
  第59回日本アレルギー学会秋季学術大会
- Place of Presentation
  秋田市
- Year and Date
  2009-10-29
- Data Source
  KAKENHI-PROJECT-20060001
[Presentation] 新しい自己認識レセプターPIRによる免疫制御と疾患2005
- Author(s)
  高井俊行
- Organizer
  日本分子生物学会年会
- Place of Presentation
  福岡市
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17209017
[Presentation] A novel target recognition mechanism by NK cells by activating CD200 receptor2005
- Author(s)
  Ishikawa T, Shiratori K, Arase, Takai T
- Organizer
  Annual Meeting of the Japanese Society for Immunology
- Place of Presentation
  Yokohama
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17209017
[Presentation] Involvement of Fcy receptors in the autoimmune type I diabetes of NOD mice2005
- Author(s)
  Inoue Y, Nakamura A, Takai T
- Organizer
  Annual Meeting of the Japanese Society for Immunology
- Place of Presentation
  Yokohama
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17209017
[Presentation] Enhanced MHC class I-restricted antigen presentation by Paired immunoglobulin-like receptor (PIR) -B deficient dendritic cell.2005
- Author(s)
  Endo S, Nakamura A, Takai T
- Organizer
  第35回目本免疫学会総会・学術集会
- Place of Presentation
  パシフィコ横浜
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17209017
[Presentation] Plexin-Al utilizes the Trem-2/DAP12 receptor complex as a co-receptor in the immune system.2005
- Author(s)
  Takegahara N, Kumanogoh A, Takamatsu H, Takai T, Kikutani H
- Organizer
  第35回日本免疫学会総会・学術集会
- Place of Presentation
  パシフィコ横浜
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17209017
[Presentation] NK細胞の活性化CD200レセプターを介した新たな標的細胞認識機構2005
- Author(s)
  石川哲、白鳥行大、荒瀬規子、高井俊行
- Organizer
  第35回日本免疫学会総会・学術集会
- Place of Presentation
  パシフィコ横浜
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17209017
[Presentation] Immunre diseases regulated by a novel self-recognizing receptor, PIR2005
- Author(s)
  Takai T
- Organizer
  Annual Meeting of the Molecular Biology Society of Japan
- Place of Presentation
  Fukuoka
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17209017
[Presentation] Plexin-A1 utilizes the Trem-2/DAP12 receptor complex as a co-receptor in the immune system2005
- Author(s)
  Takegahara N, Kumanogoh A, Takamatsu H, Takai T, Kikutani H
- Organizer
  Annual Meeting of the Japanese Society for Immunology
- Place of Presentation
  Yokohama
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17209017
[Presentation] Involvement of F_cγ receptors in the autoimmune type I diabetes of NOD mice.2005
- Author(s)
  Inoue Y, Nakamura A, Takai T
- Organizer
  第35回日本免疫学会総会・学術集会
- Place of Presentation
  パシフィコ横浜
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17209017
[Presentation] Enhanced MHC class I-restricted antigen presentation by Paired immunoglobulin-like receptor (PIR)-B deficient dendritic cell2005
- Author(s)
  Endo S, Nakamura A, Takai T
- Organizer
  Annual Meeting of the Japanese Society for Immunology
- Place of Presentation
  Yokohama
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17209017
[Presentation] Negative Regulation of Autoantibody Production by a B Cell Inhibitory Receptor, FcγRIIB
- Author(s)
  Toshiyuki Takai
- Organizer
  Centennial of Hashimoto Disease Symposium
- Place of Presentation
  Fukuoka
- Invited
- Data Source
  KAKENHI-PROJECT-24659215
[Presentation] Negative Regulation of Autoantibody Production by a B Cell Inhibitory Receptor, FcγRIIB
- Author(s)
  Toshiyuki Takai
- Organizer
  Centennial of Hashimoto Disease Symposium
- Place of Presentation
  Fukuoka
- Invited
- Data Source
  KAKENHI-PROJECT-24249016

1. INUI Masanori (80443985)

# of Collaborated Projects: 3 results

# of Collaborated Products: 11 results
2. ENDO Shota (70466580)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
3. 中村晃 (20344723)

# of Collaborated Projects: 2 results

# of Collaborated Products: 13 results
4. 小野栄夫 (20302218)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. Kumaki Satoru (20311566)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. TAMURA Shinri (20124604)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. KOBAYASHI Takayasu (10221970)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. HIRAGA Akira (80134047)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. TANABE Tadashi (60025624)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. YOKOYAMA Chieko (90200914)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. MORIMOTO Motoko (30250301)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 宮坂昌之 (50064613)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 松島綱治 (50222427)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 義江修 (10166910)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 長澤丘司 (80281690)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 木全弘治 (10022641)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 柳川右千夫 (90202366)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 海部知則 (90343037)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
19. Itou Ari

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. Su Mei-Tzu

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
21. IMADA Masaru

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 今田勝

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. SAKAKIBARA Tomohiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. NAKAYAMA Masafumi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
25. TSURUI Hiromichi

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
26. FUJII Hiroshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
27. KAI Katsunori

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
28. 海老名雅仁

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
29. 菊地利明

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
30. 貫和敏博

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
31. 小笠原康悦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
32. 澤新一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
33. 黒崎知博

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
34. 松本真琴

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
35. 中西憲司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
36. 田澤立之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
37. 中田光

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Takai Toshiyuki 高井 俊行

TAKAI Toshiyuki 高井 俊行

Research Projects

Research Products

Co-Researchers

Innovative elucidation of myeloid immune checkpoint LILRB functionPrincipal Investigator

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Role of immune checkpoint molecules in microglia and Alzheimer's diseasePrincipal Investigator

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Mechanism of LILRB4-mediated immune checkpointPrincipal Investigator

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Modulating immunological memory of antibody-producing cellsPrincipal Investigator

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Identification of molecular characteristics of pathogenic autoantibody-producing cellsPrincipal Investigator

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The role of immunosuppressive receptor LILRB in the pathogenesis of Kawasaki disease, and its application to the therapy.

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Platelets convert peripheral blood circulating monocytes to regulatory cells via immunoglobulin G and activating-type Fcg receptors.Principal Investigator

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The role and networks of immune and nonimmune cells in the small intestine in the early stage of gastrointestinal parasite infection.

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Novel immune regulation by PirB-related multiple ligandsPrincipal Investigator

Principal Investigator

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Elucidation of Regulatory Mechanism of B1 Cells by Human IgG Natural AntibodiesPrincipal Investigator

Principal Investigator

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免疫抑制受容体PIR-Bによる自己応答性の制御Principal Investigator

Principal Investigator

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Review Section

Research Institution

Prediction of immune disorders by evaluation of serum IgG reactivity to random peptide libraryPrincipal Investigator

Principal Investigator

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Research Institution

免疫抑制受容体PIRーBによる自己応答性の制御Principal Investigator

Principal Investigator

Project Period (FY)

Takai Toshiyuki 高井俊行

TAKAI Toshiyuki 高井俊行