Naito Kunihiko 内藤邦彦

… Alternative Names

NAITO Kunihiko 内藤邦彦

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Researcher Number	20188858
Other IDs
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Affiliation (based on the past Project Information) *help	2019 – 2021: 東京大学, 大学院農学生命科学研究科(農学部), 教授 2015 – 2017: 東京大学, 大学院農学生命科学研究科(農学部), 教授 2011 – 2015: 東京大学, 農学生命科学研究科, 教授 2010 – 2011: 東京大学, 大学院・農学生命科学研究科, 教授 2007 – 2008: The University of Tokyo, Graduate School of Agricultural and Life Sciences, Professor … More 2005 – 2006: The University of Tokyo, Graduate School of Agricultural and Life Sciences, Associate Professor, 大学院農学生命科学研究科, 助教授 1997 – 2005: 東京大学, 大学院・農学生命科学研究科, 助教授 1997: Tokyo Univ.Fac.Agri.Assoc.Professor, 農学生命科学研究科, 助教授 1994 – 1996: Univ.of Tokyo, Institute of Medical Science, Research associate, 医科学研究所, 助手 1990 – 1991: 東京大学, 医科学研究所, 助手 Less
Review Section/Research Field	Principal Investigator Applied animal science / Applied animal science / Basic Section 42030:Animal life science-related / Animal production science / Basic veterinary science/Basic zootechnical science / Basic veterinary science/Basic zootechnical science / Integrative animal science Except Principal Investigator 畜産学(含草地学) / Applied animal science / Applied animal science / Basic veterinary science/Basic zootechnical science / Basic veterinary science/Basic zootechnical science / Biological Sciences
Keywords	Principal Investigator MPF / Rb / 哺乳類卵 / ブタ卵 / 畜産学 / 応用動物 / Aurora A / APC / サイクリンB / p34^<cdc2> … More / cdh1 / cdc20 / antisense RNA / Mos / 減数分裂 / protein synthesis / タンパク質合成 / fragmentation / 卵成熟 / Wee1B / 成長途上卵 / 遺伝子 / 繁殖 / MAPK / 核移植 / MAPキナーゼ / ＺＧＡ / ＭＰＦ / Bora / Ｃｙｃｌｉｎ　Ａ / BORA / Cyclin B / Cyclin A / 家畜胚 / エクスポーチン / 核輸送 / protein degradation / mammalian oocyte / タンパク質分解 / Cell cycle / Early embryo development / Meiosis / Mammalian ova / 細胞周期 / 初期胚発生 / 哺乳動物卵子 / MRPK / nuclear transfer / enucleation / somatic cell clone / porcine oocytes / 核除去 / 体細胞クローン / matured porcine oocyte / vanadate / caffeine / oocyte aging / p34^<cde2> / 老化 / 豚卵子 / ブタ成熟卵 / バナデイト / カフェイン / 卵の老化 / MAP kinase / cyclin B / oocyte maturation / 成熟促進因子 / 卵子成熟 / 魚卵 / CRISPR/Cas / Cas9 / 魚類卵 / マウス卵 / ZFN / CRISPR / 人工ヌクレアーゼ / MAEL / レトロトランスポゾン / piRNA / PIWI / cAMP依存性キナーゼ(PKA) / AKAP / cAM依存性キナーゼ(PKA) / 発生能 / 蛋白質キナーゼ / 細胞分裂制御機構 / タンパク質キナーゼ / M期促進因子(MPF) / タンパク質キナーゼ細胞分裂制御 / プロテオーム制御因子 / クローン / マウス胚 / SP細胞 / ディファレンシャルディスプレイ / c-mos / 成熟 / 卵子 … More Except Principal Investigator トランスジェニック / loxP / EGFP / 初期胚 / キメラ / 遺伝子発現 / 胚性幹細胞 / Pseudo loxP / Cre / 遺伝子導入 / cre / 異種移植 / 減数分裂 / 受精 / chimera / germ line / マウス / embryonic stem cell / 胚盤胞 / 生殖系列キメラ / キメラ胚 / 体外受精 / histone / reprogramming / gene exuression / embyro / oocyte / 発生 / ヒストン修飾 / ヒストン / リプログラミング / 卵 / RNA interference / Galactose transferase / Medical use-transgenic farm animals / Gene manipulated farm animals / Gene knock down / トランスジェニックブタ / α-1,3-Gal / ブタ卵子 / RNAi / RNA干渉 / ガラクトース転移酵素 / 医療用家畜 / 遺伝子操作家畜 / 遺伝子ノックダウン / Gene transfer / DNA micro injection / Transgenic mice / IoxP / CAG / psedoloxp / Pseudoloxp / Cre酵素 / loxp / DNA顕微注入 / トランスジェニックマウス / Transgeic animals / restriction enzyme / the Dpn I-Bal 31 / DNA microinjection / co-injection / マーカー遺伝子 / マウス胚 / 形質転換家畜 / transgenic embryo / 蛍光胚 / xenotransplantation / pig / LIF / primordial germ cell / germ lne chimera / 血血病抑制因子 / 臓器移植 / ブタ / 始原生殖細胞 / 白血病抑制因子 / 生殖細胞系列 / adenovirus / chimeras / parthenogenesis / endothelin / acrosin / cyclin / fertilization / oocyte maturation / ベータガラクトシダーゼ / メタロチオネイン / 顕微注入 / 胚培養 / レポーター遺伝子 / 卵丘 / 性判別 / 性分化 / アデノウイルスベクター / エンドセリン / 単為発生 / アクロシン / サイクリン / 卵成熟 / mouse / pluripotency / blastocyst / culture / gene targeting / Embryonic stem cell / 内細胞塊 / フィ-ダ-細胞 / 未分化細胞 / 生殖細胞 / フィーダー細胞 / 白血病抑制因子(LIF) / 遺伝子の標的組込み / 生殖系列 / 共培養 / 注入キメラ / 内部細胞塊 / embryo transfer / gene expression / germ line chimera / chimeric embryo / in vitro fertilization / transgenic animal / gamete / 配偶子 / 卵子 / カルシウム / 透明帯 / 胚移植 / 遺伝子導入動物 / 精子 / 過形成 / 酵素 / シグナル伝達 / 上皮細胞 / がん Less

Research for the molecular mechanism of developmental control aimed at improving the developmental potential of livestock embryosPrincipal Investigator
- Principal Investigator
  
  Naito Kunihiko
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 42030:Animal life science-related
- Research Institution
  The University of Tokyo
Research for nuclear-transport-factors functioning in mammalian oocyte meiosisPrincipal Investigator
- Principal Investigator
  
  Naito Kunihiko
- Project Period (FY)
  2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Animal production science
- Research Institution
  The University of Tokyo
Study on practical application of zinc finger nuclease for gene knockout animal productionPrincipal Investigator
- Principal Investigator
  
  Naito Kunihiko
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Integrative animal science
- Research Institution
  The University of Tokyo
Analyses of the involvement of LTR-transposon in meiotic regulation of mammalian oocytes.Principal Investigator
- Principal Investigator
  
  NAITO Kunihiko
- Project Period (FY)
  2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Applied animal science
- Research Institution
  The University of Tokyo
Challenging research for functional analyses of piRNA/PIWI in mammalian female germ cellsPrincipal Investigator
- Principal Investigator
  
  NAITO Kunihiko
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Applied animal science
- Research Institution
  The University of Tokyo
Studies for molecular mechanism of meiotic-competence-acquisition in porcine growing oocytesPrincipal Investigator
- Principal Investigator
  
  NAITO Kunihiko
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Applied animal science
- Research Institution
  The University of Tokyo
Analyses for the mechanism of M-phase regulation in livestock oocytes with special focus on proteome control factors and protein kinases.Principal Investigator
- Principal Investigator
  
  NAITO Kunihiko
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Applied animal science
- Research Institution
  The University of Tokyo
上皮細胞の過形成とがん化の分子機構
- Principal Investigator
  
  CHIDA Kazuhiro
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
Mechanism for the reprogramming of gene expression in the oocytes and preimplantation embryos
- Principal Investigator
  
  AOKI Fugaku
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Applied animal science
- Research Institution
  The University of Tokyo
Analyses for the regulation mechanisms of protein synthesis and degradation which is aimed for the improvement of the availability in live stock oocyte for the developmental technologyPrincipal Investigator
- Principal Investigator
  
  NAITO Kunihiko
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Basic veterinary science/Basic zootechnical science
- Research Institution
  THE UNIVERSITY OF TOKYO
Basic study on development of transgenic farm animals for medical use by using RNA interference
- Principal Investigator
  
  TOJO Hideaki
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Basic veterinary science/Basic zootechnical science
- Research Institution
  The University of Tokyo
哺乳動物のside population細胞核を用いた体細胞クローン作出の高率化Principal Investigator
- Principal Investigator
  
  内藤邦彦
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Applied animal science
- Research Institution
  The University of Tokyo
Analyses for the regulation of mammalian oocyte/early embryo specific cell cycle which is aimed for introduction into somatic cellsPrincipal Investigator
- Principal Investigator
  
  NAITO Hideaki
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Basic veterinary science/Basic zootechnical science
- Research Institution
  The University of Tokyo
Development and use of production method for transgenic animals using Cre/pseudo IoxP system
- Principal Investigator
  
  TOJO Hideaki
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Basic veterinary science/Basic zootechnical science
- Research Institution
  The University of Tokyo
Studies for Production of Porcine Somatic Cell Clone Animals using Molecular GeneticsPrincipal Investigator
- Principal Investigator
  
  NAITO Kunihiko
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Applied animal science
- Research Institution
  THE UNIVERSITY OF TOKYO
Studies on development of transgenic animals for use the in medical science.
- Principal Investigator
  
  TOJO Hidcaki
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (A).
- Research Field
  
  Applied animal science
- Research Institution
  THE UNIVERSITY OF TOKYO
Studies on molecular mechanisms and artificial regulation of maturation and aging of mammalian oocytesPrincipal Investigator
- Principal Investigator
  
  NAITO Kunihiko
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied animal science
- Research Institution
  The University of Tokyo
哺乳動物の卵子成熟を制御する遺伝子の同定と卵細胞質内因子の変化に関する研究Principal Investigator
- Principal Investigator
  
  内藤邦彦
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied animal science
- Research Institution
  The University of Tokyo
Porcine embryonic stem cells forming germ line chimeras
- Principal Investigator
  
  SATO Eimei
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Applied animal science
- Research Institution
  Faculty of Agriculture, Tohoku University
  The University of Tokyo
Study of the cell cycle regulation mechanism in oocyte maturationPrincipal Investigator
- Principal Investigator
  
  NAITO Kunihiko
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Applied animal science
- Research Institution
  The University of Tokyo
Studies on te regulatory mechanisms of gene expression in early embryos
- Principal Investigator
  
  TOYODA Yutaka
- Project Period (FY)
  1992 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (A)
- Research Field
  
  畜産学(含草地学)
- Research Institution
  The University of Tokyo
STUDIES ON DERIVATION AND CULTURE OF EMBRYONIC STEM CELLS
- Principal Investigator
  
  TOYODA Yutaka
- Project Period (FY)
  1991 – 1993
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  畜産学(含草地学)
- Research Institution
  THE UNIVERSITY OF TOKYO
Basic study on the production of transgenic animals through gametes and embryonic stem cells
- Principal Investigator
  
  TOYODA Yutaka
- Project Period (FY)
  1990 – 1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  畜産学(含草地学)
- Research Institution
  The Institute of Medical Science, The University of Tokyo

[Book] 哺乳動物の発生工学2014
- Author(s)
  内藤　邦彦
- Total Pages
  195
- Publisher
  朝倉書店
- Data Source
  KAKENHI-PROJECT-25252056
[Book] 受精と初期発生:日本繁殖生物学会編、繁殖生物学2013
- Author(s)
  内藤邦彦
- Publisher
  インターズー、東京
- Data Source
  KAKENHI-PROJECT-22380147
[Book] 繁殖生物学：受精と初期発生2013
- Author(s)
  内藤　邦彦
- Total Pages
  313
- Publisher
  インターズー
- Data Source
  KAKENHI-PROJECT-22380147
[Book] 卵子の生物学的評価;日本哺乳動物卵子学会編、生命の誕生に向けて2011
- Author(s)
  内藤邦彦、藤井渉、西村鷹則
- Publisher
  近代出版、東京
- Data Source
  KAKENHI-PROJECT-22380147
[Book] 生命の誕生に向けて:卵子の生物学的評価2011
- Author(s)
  内藤邦彦
- Total Pages
  303
- Publisher
  近代出版
- Data Source
  KAKENHI-PROJECT-22380147
[Book] 新動物生殖学:初期胚発生と胚の初期分化2011
- Author(s)
  内藤邦彦
- Total Pages
  203
- Publisher
  朝倉書店
- Data Source
  KAKENHI-PROJECT-22380147
[Book] 初期胚発生と胚の初期分化:佐藤英明編、新動物生殖学2011
- Author(s)
  内藤邦彦
- Publisher
  朝倉書店、東京
- Data Source
  KAKENHI-PROJECT-22380147
[Journal Article] Chd9 mediates highly loosened chromatin structure in growing mouse oocytes2018
- Author(s)
  Ooga Masatoshi、Funaya Satoshi、Hashioka Yuki、Fujii Wataru、Naito Kunihiko、Suzuki Masataka G.、Aoki Fugaku
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 500 Issue: 3 Pages: 583-588
- DOI
  10.1016/j.bbrc.2018.04.105
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K15394, KAKENHI-PROJECT-25252056, KAKENHI-PUBLICLY-16H01215
[Journal Article] Contributions of UBE2C and UBE2S to meiotic progression of porcine oocytes2018
- Author(s)
  Fujioka YA, Onuma A, Fujii W, Sugiura K, Naito K.
- Journal Title
  
  J. Reprod. Dev.
  
  Volume: 64 Issue: 3 Pages: 253-259
- DOI
  10.1262/jrd.2018-006
- NAID
  130007409956
- ISSN
  0916-8818, 1348-4400
- Language
  English
- Data Source
  KAKENHI-PROJECT-25252056, KAKENHI-PROJECT-17H03900
[Journal Article] Efficient mutagenesis by CRISPR/Cas system during meiotic maturation of porcine oocytes2017
- Author(s)
  Onuma A, Fujii W, Sugiura K, Naito K.
- Journal Title
  
  J. Reprod. Dev.
  
  Volume: 63 Issue: 1 Pages: 45-50
- DOI
  10.1262/jrd.2016-094
- NAID
  130005332294
- ISSN
  0916-8818, 1348-4400
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25252056, KAKENHI-PROJECT-15K14884, KAKENHI-PROJECT-26712025
[Journal Article] Efficient generation of genome-modified mice using Campylobacter jejuni-derived CRISPR/Cas.2017
- Author(s)
  Fujii W, Ikeda A, Sugiura K, Naito K.
- Journal Title
  
  International Jornal of Molecular Sciences
  
  Volume: 18 Issue: 11 Pages: 2286-2286
- DOI
  10.3390/ijms18112286
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25252056, KAKENHI-PROJECT-26712025
[Journal Article] Application of dead end-knockout zebrafish to recipients of germ cell transplantation.2017
- Author(s)
  Li Q, Fujii W, Naito K, Yoshizaki G.
- Journal Title
  
  Molecular Reproduction and Development
  
  Volume: 84 Issue: 10 Pages: 1100-1111
- DOI
  10.1002/mrd.22870
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25252056, KAKENHI-PLANNED-25114005
[Journal Article] Analyses of EMI functions on meiotic maturation of porcine oocytes.2016
- Author(s)
  Fujioka YA, Onuma A, Fujii W, Sugiura K, Naito K.
- Journal Title
  
  Molecular Reproduction and Development
  
  Volume: 83 Issue: 11 Pages: 983-992
- DOI
  10.1002/mrd.22738
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25252056
[Journal Article] Zygote-mediated generation of genome-modified mice using Streptococcus thermophiles 1-derived CRISPR/Cas system.2016
- Author(s)
  Fujii W, Kakuta S, Yoshioka S, Kyuwa S,Sugiura K,Naito K.
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 477 Issue: 3 Pages: 473-476
- DOI
  10.1016/j.bbrc.2016.06.070
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25252056, KAKENHI-PROJECT-15K14884, KAKENHI-PROJECT-26712025
[Journal Article] Development of a mono-promoter-driven CRISPR/Cas9 system in mammalian cells2015
- Author(s)
  Shin Yoshioka, Wataru Fujii, Tetsuhiro Ogawa, Koji Sugiura, and Kunihiko Naito
- Journal Title
  
  Scientific Reports
  
  Volume: 5 Issue: 1 Pages: 18341-18341
- DOI
  10.1038/srep18341
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K14884, KAKENHI-PROJECT-15J01244, KAKENHI-PROJECT-26712025, KAKENHI-PROJECT-25252056
[Journal Article] Finding of a highly efficient ZFN pair for <i>Aqpep</i> gene functioning in murine zygotes2015
- Author(s)
  Fujii W, Onuma A, Yoshioka S, Nagashima K, Sugiura K, Naito K
- Journal Title
  
  J. Reprod. Dev.
  
  Volume: 61 Issue: 6 Pages: 589-593
- DOI
  10.1262/jrd.2015-087
- NAID
  130005113567
- ISSN
  0916-8818, 1348-4400
- Language
  English
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26712025, KAKENHI-PROJECT-25252056
[Journal Article] Efficient generation of genome-modified mice via offset-nicking by CRISPR/Cas system.2014
- Author(s)
  Fujii W, Onuma A, Sugiura K, Naito K.
- Journal Title
  
  Biochem Biophys Res Comm
  
  Volume: 445 Issue: 4 Pages: 791-794
- DOI
  10.1016/j.bbrc.2014.01.141
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25252056, KAKENHI-PROJECT-25892010
[Journal Article] One-step Generation of Phenotype-expressing Triple-knockout Mice with Heritable Mutated Alleles by the CRISPR/Cas9 System2014
- Author(s)
  Fujii W, Onuma A, Sugiura K, Naito K.
- Journal Title
  
  J. Reprod. Dev.
  
  Volume: 60 Issue: 4 Pages: 324-327
- DOI
  10.1262/jrd.2013-139
- NAID
  130004137824
- ISSN
  0916-8818, 1348-4400
- Language
  English
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25252056, KAKENHI-PROJECT-26712025
[Journal Article] Nakamura K, Fujii W, Tsuboi M, Tanihata J, Teramoto N, Takeuchi S, Naito K, Yamanouchi K, Nishihara M2014
- Author(s)
  Nakamura K, Fujii W, Tsuboi M, Tanihata J, Teramoto N, Takeuchi S, Naito K, Yamanouchi K, Nishihara M
- Journal Title
  
  Scientific Reports
  
  Volume: 4 Issue: 1 Pages: 5635-5635
- DOI
  10.1038/srep05635
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-12J07714, KAKENHI-PROJECT-23228004, KAKENHI-PROJECT-25252056, KAKENHI-PROJECT-25292185, KAKENHI-PROJECT-25860306, KAKENHI-PROJECT-26712025
[Journal Article] Relationships Between the Appearances and Changes of Estrous Signs and the Estradiol-17β Peak, Luteinizing Hormone Surge and Ovulation During the Periovulatory Period in Lactating Dairy Cows Kept in Tie-stalls2014
- Author(s)
  Shimaoka T, Nishimura T, Kano K, Naito K
- Journal Title
  
  J. Reprod. Dev.
  
  Volume: 60 Issue: 2 Pages: 106-114
- DOI
  10.1262/jrd.2013-119
- NAID
  130003390822
- ISSN
  0916-8818, 1348-4400
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22380147
[Journal Article] Cytoplasmic Anchoring of cAMP-Dependent Protein Kinase (PKA) by A-Kinase Anchor Proteins (AKAPs) Is Required for Meiotic Arrest of Porcine Full-Grown and Growing Oocytes2014
- Author(s)
  Nishimura T, Fujii W, Sugiura K, Naito K
- Journal Title
  
  Biol Reprod
  
  Volume: 90 Issue: 3
- DOI
  10.1095/biolreprod.113.114736
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22380147, KAKENHI-PROJECT-25252056
[Journal Article] Analyses of the Involvement of PKA Regulation Mechanism in Meiotic lncon〕petence of Porcine Growing Oocytes.2013
- Author(s)
  Takanori Nishimura
- Journal Title
  
  Biology of Reproduction
  
  Volume: 87 Issue: 3
- DOI
  10.1095/biolreprod.112.101279
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J02886, KAKENHI-PROJECT-11J03140, KAKENHI-PROJECT-22380147
[Journal Article] A-kinase anchor protein 1 (AKAP1) regulates cABP-dependent protein kinase (PKA) localization and is involved in meiotic maturation of porcine oocytes.2013
- Author(s)
  Takanori Nishimura, et al.
- Journal Title
  
  Biology of Reproduction
  
  Volume: 88 Issue: 4
- DOI
  10.1095/biolreprod.112.106351
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J03140, KAKENHI-PROJECT-22380147
[Journal Article] Repeatable Construction Method for Engineered Zinc Finger Nuclease Based on2013
- Author(s)
  Wataru Fujii
- Journal Title
  
  PloS ONE
  
  Volume: 8 Issue: 3 Pages: e59801-e59801
- DOI
  10.1371/journal.pone.0059801
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J02886, KAKENHI-PROJECT-25252056
[Journal Article] Efficient generation of large-scale genome-modified-mice using gRNA and CAS9 endonuclease.2013
- Author(s)
  Fujii W, Kawasaki K, Sugiura K, Naito K.
- Journal Title
  
  Nucleic Acids Res.
  
  Volume: 41 Issue: 20 Pages: e187-e187
- DOI
  10.1093/nar/gkt772
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25252056, KAKENHI-PROJECT-25892010
[Journal Article] CDK7 and CCNH are components of CDK-activating kinase and are required for meiotic progression of pig oocytes2011
- Author(s)
  藤井渉
- Journal Title
  
  Biology of Reproduction
  
  Volume: 85 Issue: 6 Pages: 1124-1132
- DOI
  10.1095/biolreprod.111.091801
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J02886, KAKENHI-PROJECT-22380147
[Journal Article] Preimplantation-embryo-specific Cell-cycle Regulation is Attributable to a Low Expression of Retinoblastoma Protein Rather Than Its Phosphorylation2011
- Author(s)
  Egashira A, Kano K, Naito K
- Journal Title
  
  J. Reprod. Dev.
  
  Volume: 57 Issue: 4 Pages: 492-499
- DOI
  10.1262/jrd.10-170O
- NAID
  130000676919
- ISSN
  0916-8818, 1348-4400
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22380147
[Journal Article] Upstream factors regulating the maturation/M-phase promoting factor activity durine oocyte maturation.2010
- Author(s)
  Naito K
- Journal Title
  
  Journal of Mammalian Ova Research
  
  Volume: 27 Pages: 27-34
- Data Source
  KAKENHI-PROJECT-22380147
[Journal Article] Upstream factors regulating the maturation/M-phase promoting factor activity during oocyte maturation.2010
- Author(s)
  Naito K, (他7名, 1番目)
- Journal Title
  
  Journal of Mammalian Ova Research 27
  
  Pages: 27-34
- NAID
  10026350430
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19380155
[Journal Article] Porcine CPEB1 is involved in Cyclin B translation and meiotic resumption in porcine oocytes.2010
- Author(s)
  Nishimura Y, Kano K, Naito K
- Journal Title
  
  Animal Science Jourmal 81(in press)
- NAID
  10027889163
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19380155
[Journal Article] Critical effect of pigWee1B on the regulation of meiotic resumption in porcine immature oocytes.2009
- Author(s)
  Shimaoka T, Naito K, (他2名, 4番目)
- Journal Title
  
  Cell Cycle 8
  
  Pages: 2375-2384
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19380155
[Journal Article] Insufficient amount of Cdc2 and continuous activation of Wee1 B are the cause of meiotic failure in porcine growing oocytes.2009
- Author(s)
  Nishimura T, Naito K, (他2名, 4番目)
- Journal Title
  
  Journal of Reproduction and Development 55
  
  Pages: 553-557
- NAID
  10025616637
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19380155
[Journal Article] Porcine Aurora A accelerates Cyclin B and Mos synthesis and promotes meiotic resumption of porcine oocytes.2009
- Author(s)
  Nishimura Y, Naito K, (他2名, 4番目)
- Journal Title
  
  Animal Reproduction Science 113
  
  Pages: 114-124
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19380155
[Journal Article] 哺乳類卵の減数分裂過程におけるヒストンアセチル化制御について.2008
- Author(s)
  遠藤墾, 内藤邦彦
- Journal Title
  
  動物遺伝育種研究 36
  
  Pages: 167-175
- NAID
  10024932531
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19380155
[Journal Article] Nuclear histone deacetylases are not required for global histone deacetylation during meiotic maturation in porcine oocytes.2008
- Author(s)
  Endo T, Kano K, Naito K
- Journal Title
  
  Biology of Reproduction 78
  
  Pages: 1073-1080
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19380155
[Journal Article] Functions of FZR1 and CDC20, activators of the anaphase-promoting complex (APC), during meiotic maturation of porcine oocytes.2008
- Author(s)
  Yamamuro T, Kano K, Naito K
- Journal Title
  
  Biology of Reproduction 79
  
  Pages: 1202-1209
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19380155
[Journal Article] Mos and the mitogen-activated protein kinase do not show cytostatic factor activity in early mouse embryos.2007
- Author(s)
  Kashima K, Kano K, Naito K
- Journal Title
  
  Journal of Reproduction and Development 53
  
  Pages: 1175-1182
- NAID
  10020172586
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19380155
[Journal Article] Porcine SPDYA2 (RINGO A2) stimulates CDC2 activity and accelerates meiotic maturation of porcine oocytes.2007
- Author(s)
  Kume S, Endo T, Nishimura Y, Kano K, Naito K.
- Journal Title
  
  Biology of Reproduction 76
  
  Pages: 440-447
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17380173
[Journal Article] Meiotic resumption of porcine immature oocytes is prevented by ooplasmic Gs α functions.2007
- Author(s)
  Morikawa M, Naito K, (他5名, 7番目)
- Journal Title
  
  Journal of Reproduction and Development 53
  
  Pages: 1151-1157
- NAID
  10020172496
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19380155
[Journal Article] Activities of maturation-promoting factor (MPF) and mitogen-activated protein kinase (MAPK) are not required for the global histone deacetylation observed after germinal vesicle breakdown GVBD in porcine oocytes.2006
- Author(s)
  Endo T, Naito K, Kume S, Nishimura Y, Kashima K, Tojo H.
- Journal Title
  
  Reproduction 131
  
  Pages: 439-447
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17380173
[Journal Article] Study of germinal vesicle requirement for the normal kinetics of Maturation/M-phase Promoting Factor activity during porcine oocyte maturation.2006
- Author(s)
  Sugiura K, Naito K, Endo T, Tojo H.
- Journal Title
  
  Biology of Reproduction 74
  
  Pages: 593-600
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17380173
[Journal Article] Inhibition of mitogen activated protein kinase activity induces parthenogenetic activation but increases cyclin B accumulation during porcine oocyte maturation.2005
- Author(s)
  Takakura I, Naito K, Iwamori N, Yamashita M, Kume S, Tojo H.
- Journal Title
  
  Journal of Reproduction and Development 51
  
  Pages: 617-626
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17380173
[Journal Article] Cyclin A2-CDK2 regulates embryonic gene activation in 1-cell mouse embryos2005
- Author(s)
  Hara KT, Oda S, Naito K, Nagata M, Schultz RM, Aoki F
- Journal Title
  
  Dev. Biol. 286
  
  Pages: 102-113
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17380166
[Journal Article] Changes in histone modifications during in vitro maturation of porcine oocytes2005
- Author(s)
  Endo T, Naito K, Aoki F, Kume S, Tojo H
- Journal Title
  
  Mol. Reprod. Dev. 71
  
  Pages: 123-128
- NAID
  10015712405
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17380166
[Presentation] ブタ卵成熟、初期胚発生におけるCyclin A(CCNA)の機能解析2021
- Author(s)
  江口諒・淀澤天斗・藤井渉・杉浦幸二・内藤邦彦
- Organizer
  第128回日本畜産学会
- Data Source
  KAKENHI-PROJECT-19H03135
[Presentation] 生殖細胞欠損ニジマスの作出とその代理親魚への応用2018
- Author(s)
  藤原亮・片山直人・藤井渉・内藤邦彦・吉崎悟朗
- Organizer
  平成30年度公益社団法人日本水産学会春季大会
- Data Source
  KAKENHI-PROJECT-25252056
[Presentation] C. jejuni由来CRISPR/Casによるゲノム改変マウスの作製2017
- Author(s)
  藤井渉・池田有沙・杉浦幸二・内藤邦彦
- Organizer
  第123回日本畜産学会
- Data Source
  KAKENHI-PROJECT-25252056
[Presentation] 生殖細胞欠損ヤマメの作出とその代理親魚への応用2017
- Author(s)
  藤原　亮・片山直人・藤井　渉・内藤邦彦・吉崎悟朗
- Organizer
  平成29年度公益社団法人日本水産学会春季大会
- Data Source
  KAKENHI-PROJECT-25252056
[Presentation] ブタ卵母細胞成熟過程における核外移行因子exportin-1の機能解析2016
- Author(s)
  小沼　あすか・藤井　渉・杉浦　幸二・内藤　邦彦
- Organizer
  第121回日本畜産学会
- Place of Presentation
  日本獣医生命科学大学（東京都・武蔵野市）
- Year and Date
  2016-03-28
- Data Source
  KAKENHI-PROJECT-15K14841
[Presentation] Involvement of Chd9 in highly loosened chromatin structure in growing oocytes.2016
- Author(s)
  Ooga M, Fujii W , Naito K, Aoki F.
- Organizer
  International Symposium on “Epigenome Dynamics and Regulation in Germ Cells”
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25252056
[Presentation] ブタ卵母細胞成熟過程における核外移行因子exportin-1の機能解析2016
- Author(s)
  小沼あすか・藤井　渉・杉浦幸二・内藤邦彦
- Organizer
  第121回日本畜産学会
- Place of Presentation
  日本獣医生命科学大学（東京都武蔵野市）
- Year and Date
  2016-03-27
- Data Source
  KAKENHI-PROJECT-25252056
[Presentation] CRISPR/Casシステムを利用したゲノム改変マウス作製法の開発2015
- Author(s)
  藤井渉・杉浦幸二・内藤邦彦
- Organizer
  第16回日本動物遺伝育種学会
- Place of Presentation
  神戸大学（兵庫県神戸市）
- Year and Date
  2015-11-06
- Data Source
  KAKENHI-PROJECT-25252056
[Presentation] ドナーDNA条件がCRISPR/Casによるマウス前核期卵のノックインに与える影響2015
- Author(s)
  永島圭介・藤井　渉・杉浦幸二・内藤邦彦
- Organizer
  第15回東京大学生命科学シンポジウム
- Place of Presentation
  東京大学（東京都文京区）
- Year and Date
  2015-06-27
- Data Source
  KAKENHI-PROJECT-25252056
[Presentation] 生殖細胞欠損サケ科魚類の大量生産を目指したdead end遺伝子のゲノム編集2015
- Author(s)
  片山直人・定家咲子・矢澤良輔・藤井渉・内藤邦彦・吉崎悟朗
- Organizer
  第17回マリンバイオテクノロジー学会
- Place of Presentation
  東京海洋大学（東京都港区）
- Year and Date
  2015-05-30
- Data Source
  KAKENHI-PROJECT-25252056
[Presentation] オフセットニッキング法によるゲノム改変マウスの作製2014
- Author(s)
  藤井　渉・小沼　あすか・杉浦　幸二・内藤　邦彦
- Organizer
  第118回日本畜産学会
- Place of Presentation
  つくば国際会議場（エポカルつくば）（茨城県つくば市）
- Data Source
  KAKENHI-PROJECT-25252056
[Presentation] ブタ卵成熟におけるMASTLの機能解析2013
- Author(s)
  西村鷹則・鈴木真理・杉浦幸二・内藤邦彦
- Organizer
  第116回日本畜産学会
- Data Source
  KAKENHI-PROJECT-22380147
[Presentation] 最適化されたCAS9/gRNAシステムによるゲノム改変マウスの作製2013
- Author(s)
  藤井　渉・川崎　紅・杉浦　幸二・内藤　邦彦
- Organizer
  第106回日本繁殖生物学会
- Place of Presentation
  東京農工大学(東京都府中市）
- Data Source
  KAKENHI-PROJECT-25252056
[Presentation] The regulation mechanism of phosphorylation of CDC2 threonine 161 during porcine oocyte maturation2012
- Author(s)
  Fujii W, Nishimura T, Kano K, Koji Sugiura, K Naito K
- Organizer
  45th SSR Annual Meeting
- Place of Presentation
  (Win the award for 2012 Animal Reproduction in Agriculture Research Fellowship, and a special"Regional Abstract Award")
- Data Source
  KAKENHI-PROJECT-22380147
[Presentation] AKAP-5・AKAP-7αの抑制がブタ成長途上卵の減数分裂を誘起する2012
- Author(s)
  西村鷹則・藤井渉・杉浦幸二・内藤邦彦
- Organizer
  第115回日本畜産学会
- Place of Presentation
  (優秀発表賞受賞)
- Year and Date
  2012-03-28
- Data Source
  KAKENHI-PROJECT-22380147
[Presentation] ブタ卵成熟におけるCDC25の機能解析2012
- Author(s)
  西村鷹則・杉浦幸二・内藤邦彦
- Organizer
  第105回日本繁殖生物学会
- Data Source
  KAKENHI-PROJECT-22380147
[Presentation] ブタ卵成熟過程におけるCDC2 161番スレオニンのリン酸化制御機構2012
- Author(s)
  藤井渉、西村鷹則、加納聖、杉浦幸二、内藤邦彦
- Organizer
  第105回日本繁殖生物学会
- Data Source
  KAKENHI-PROJECT-22380147
[Presentation] ブタ卵母細胞の減数分裂におけるAKAPの機能解析2012
- Author(s)
  西村鷹則・杉浦幸二・内藤邦彦
- Organizer
  第12回東京大学生命科学シンポジウム
- Year and Date
  2012-06-30
- Data Source
  KAKENHI-PROJECT-22380147
[Presentation] Involvement of PKA and AKAP in Meiotic Competence of Porcine Growing Oocytes2011
- Author(s)
  Nishimura T, Fujii W, Kano K, Sugiura K, Naito K
- Organizer
  2nd World Congress Reproductive Biology
- Data Source
  KAKENHI-PROJECT-22380147
[Presentation] ブタ未成熟卵におけるPIWIの存在とGV維持機能2011
- Author(s)
  山田祐子・西村鷹則・藤井渉・加納聖・杉浦幸二・内藤邦彦
- Organizer
  第114回日本畜産学会
- Place of Presentation
  北里大学
- Data Source
  KAKENHI-PROJECT-23658221
[Presentation] ブタ未成熟卵におけるPIWI の存在と GV 維持機能2011
- Author(s)
  山田祐子・西村鷹則・藤井渉・加納聖・杉浦幸二・内藤邦彦
- Organizer
  第114回日本畜産学会
- Year and Date
  2011-08-26
- Data Source
  KAKENHI-PROJECT-23658221
[Presentation] ブタ卵母細胞における減数分裂再開能とPKA局在制御機構の関与2011
- Author(s)
  西村鷹則・加納聖・杉浦幸二・内藤邦彦
- Organizer
  第11回東京大学生命科学シンポジウム
- Year and Date
  2011-05-01
- Data Source
  KAKENHI-PROJECT-22380147
[Presentation] ブタ卵母細胞におけるA-kinase anchoring protein (AKAP)の発現と機能2011
- Author(s)
  西村鷹則・藤井渉・加納聖・杉浦幸二・内藤邦彦
- Organizer
  第52回日本哺乳動物卵子学会
- Place of Presentation
  (学術奨励賞口演部門受賞)
- Year and Date
  2011-05-21
- Data Source
  KAKENHI-PROJECT-22380147
[Presentation] ブタ成長途上卵における減数分裂能欠損の分子機構2010
- Author(s)
  西村鷹則・藤井渉・加納聖・内藤邦彦
- Organizer
  第10回東京大学生命科学シンポジウム
- Year and Date
  2010-05-01
- Data Source
  KAKENHI-PROJECT-22380147
[Presentation] ブタCdk活性化キナーゼ(CAK)の卵成熟過程における関与2010
- Author(s)
  藤井渉・西村鷹則・加納聖・内藤邦彦
- Organizer
  第10回東京大学生命科学シンポジウム
- Year and Date
  2010-05-01
- Data Source
  KAKENHI-PROJECT-22380147
[Presentation] ブタ未成長卵の減数分裂再開能におけるPKA活性制御機構の関与2010
- Author(s)
  西村鷹則・藤井渉・加納聖・内藤邦彦
- Organizer
  第103回日本繁殖生物学会
- Place of Presentation
  (優秀発表賞受賞)
- Data Source
  KAKENHI-PROJECT-22380147
[Presentation] ドナーDNA の状態がCRISPR/Casを用いたマウス前核期卵へのノックインに及ぼす影響
- Author(s)
  永島圭介・藤井　渉・杉浦幸二・内藤邦彦
- Organizer
  第119回日本畜産学会
- Place of Presentation
  宇都宮大学
- Year and Date
  2015-03-28 – 2015-03-30
- Data Source
  KAKENHI-PROJECT-25252056
[Presentation] ブタ卵母細胞の減数分裂過程におけるFBXO5（EMI1）およびFBXO43（EMI2）の関与
- Author(s)
  藤岡良江・藤井　渉・杉浦　幸二・内藤邦彦
- Organizer
  第107回日本繁殖生物学会
- Place of Presentation
  帯広畜産大学
- Year and Date
  2014-08-20 – 2014-08-24
- Data Source
  KAKENHI-PROJECT-25252056
[Presentation] CRISPR/Cas法を用いた筋ジストロフィーモデルラットの作出
- Author(s)
  中村克行・藤井渉・坪井誠也・谷端淳・寺本奈保美・竹内志帆・内藤邦彦・山内啓太郎・西原真杉
- Organizer
  第157回日本獣医学会
- Place of Presentation
  北海道大学
- Year and Date
  2014-09-09 – 2014-09-12
- Data Source
  KAKENHI-PROJECT-25252056
[Presentation] Generation of Dystrophinmutated rats with a CRISPR/Cas system as a new animal model of muscular dystrophy.
- Author(s)
  Nakamura K, Fujii W, Tsuboi M, Tanihata J, Teramoto N, Takeuchi S, Naito K, Yamanouchi K, Nishihara M.
- Organizer
  2014 FASEB Science Research Conferences
- Place of Presentation
  Steamboat Springs, Colorado, USA
- Year and Date
  2014-07-20 – 2014-07-25
- Data Source
  KAKENHI-PROJECT-25252056
[Presentation] CRISPR/Casシステムを用いたブタ卵成熟過程におけるゲノム改変効率の検討
- Author(s)
  小沼あすか・藤井　渉・杉浦幸二・内藤邦彦
- Organizer
  第107回日本繁殖生物学会
- Place of Presentation
  帯広畜産大学
- Year and Date
  2014-08-20 – 2014-08-24
- Data Source
  KAKENHI-PROJECT-25252056
[Presentation] Knockout of dead end gene using zinc finger nuclease in zebrafish
- Author(s)
  Li Q • Fujii W • Naito K • Yoshizaki G
- Organizer
  平成26年度日本水産学会秋季大会
- Place of Presentation
  九州大学箱崎キャンパス
- Year and Date
  2014-09-19 – 2014-09-22
- Data Source
  KAKENHI-PROJECT-25252056

1. CHIDA Kazuhiro (00192188)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
2. AOKI Fugaku (20175160)

# of Collaborated Projects: 6 results

# of Collaborated Products: 2 results
3. TOJO Hidcaki (20041668)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
4. KYUWA Shigeru (30177943)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
5. Kikuchi Kazuhiro (20360456)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
6. TOYODA Yutaka (90050418)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
7. SATO Eimei (80093243)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
8. YAMANOUCHI Keitarou (70272440)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. Yoshizaki Goro (70281003)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
10. Sugiura Koji (20595623)

# of Collaborated Projects: 1 results

# of Collaborated Products: 14 results
11. KATAGIRI Takuya (70126100)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. IBA Hideo (60111449)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. IWAKURA Yoichirou (10089120)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. SHIOTA Kunio (80196352)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. NARUSE Katsutoshi (50291323)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 甲斐知恵子 (10167330)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 中山直樹 (80227967)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 浜田博司 (00208589)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 小野寺節 (90012781)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. MIKI Keisaburou

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 藤井渉

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
22. 大我政敏

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Naito Kunihiko 内藤 邦彦

NAITO Kunihiko 内藤 邦彦

Research Projects

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Research for the molecular mechanism of developmental control aimed at improving the developmental potential of livestock embryosPrincipal Investigator

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Research for nuclear-transport-factors functioning in mammalian oocyte meiosisPrincipal Investigator

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Study on practical application of zinc finger nuclease for gene knockout animal productionPrincipal Investigator

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Analyses of the involvement of LTR-transposon in meiotic regulation of mammalian oocytes.Principal Investigator

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Challenging research for functional analyses of piRNA/PIWI in mammalian female germ cellsPrincipal Investigator

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Studies for molecular mechanism of meiotic-competence-acquisition in porcine growing oocytesPrincipal Investigator

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Analyses for the mechanism of M-phase regulation in livestock oocytes with special focus on proteome control factors and protein kinases.Principal Investigator

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Analyses for the regulation mechanisms of protein synthesis and degradation which is aimed for the improvement of the availability in live stock oocyte for the developmental technologyPrincipal Investigator

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哺乳動物のside population細胞核を用いた体細胞クローン作出の高率化Principal Investigator

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Analyses for the regulation of mammalian oocyte/early embryo specific cell cycle which is aimed for introduction into somatic cellsPrincipal Investigator

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Naito Kunihiko 内藤邦彦

NAITO Kunihiko 内藤邦彦