Takahashi Ichiro 高橋一郎

… Alternative Names

takahashi ichiro 高橋一郎

TAKAHASHI Ichiro 高橋一郎

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Researcher Number	20206791
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Affiliation (Current)	2025: 京都大学, 医学研究科, 研究員
Affiliation (based on the past Project Information) *help	2024: 広島大学, 医系科学研究科(歯), 教授 2019 – 2022: 広島大学, 医系科学研究科(歯), 教授 2006: Hiroshima University, Graduate school of Biomedical science, Professor, 大学院医歯薬学総合研究科, 教授 2004 – 2005: 広島大学, 大学院・医歯薬学総合研究科, 教授 2002: 広島大学, 大学院・医歯薬学総合研究科, 教授 … More 1996 – 2001: 大阪大学, 微生物病研究所, 講師 1995: 大阪大学, 歯学部・口腔細菌学, 助手 1993 – 1995: 大阪大学, 歯学部, 助手 1988 – 1990: 国立予防衛生研究所, 歯科衛生部, 研究員 Less
Review Section/Research Field	Principal Investigator Morphological basic dentistry / Immunology / Biological Sciences / Basic Section 49070:Immunology-related / Basic Section 57020:Oral pathobiological science-related / Immunology Except Principal Investigator Immunology / 小児・社会系歯学 / Social dentistry / General surgery / 病態科学系歯学(含放射線系歯学) / Bacteriology (including Mycology)
Keywords	Principal Investigator 粘膜免疫 / 炎症性腸疾患 / NKG2D / 感染免疫 / perforin-2 / smlt2713 / S. maltophilia / 微生物・細胞内共生 / IL-15 / MICA … More / 粘膜系T細胞 / 胸腺外分化 / サイトカイン / T細胞 / 組織常在マクロファージ / 恒常性 / 炎症制御 / ミトコンドリア / 微生物細胞内共生 / 自然炎症 / マクロファージ / IL-10 / macrophage / immune metabolism / mitochondrial OCR / interleukin-10 / tissue macrophage / mucosal immunology / host microbe symbiosis / inflammatory bowel disease / intraepithelial lymphocytes / mucosal immunity / 腸上皮細胞間リンパ球 / PUBLIC CDR3 MOTIF / CROHN'S DISEASE / INFLAMMATION / EXTRATHYMIC T CELLS / MUCOSAL IMMUNOLOGY / 免疫病 / 炎症 / gut-flora / clonality / mucosal T cells / IBD / Th2 cytokine / ββ T cells / 腸内細菌 / クロナリティ- / beta / TCR beta / PCR-SSCP / Th2系サイトカイン / Bacteroides属 / Th2型サイトカイン / ββT細胞 / ワクチン / 微生物感染 / 免疫制御 / 胸腺外分化Tリンパ球 / NKG2D ligand / ノックアウトマウス / アレルギー / トレランス / 細菌毒素 / 経口ワクチン / 免疫 … More Except Principal Investigator IgA / 粘膜免疫 / Streptococcus mutans / Streptococcus sobrinus / Bacteroides vulgatus / Mucosal immune system / 経口ワクチン / 粘膜アジュバント / 粘膜免疫調節因子 / IL-12 / 粘膜ワクチン / う蝕 / マウス / fimbriae / Porphyromonas gingivalis / Vaccine / Lactic Streptococci / Dental Caries / DNA組換え / ワクチン / 乳酸菌 / 齲蝕 / mice / Protein expression / Gene transfection / HVJ-envelope / TFF peptides / クローニング / TFF3 / トレフォイルファクター / 粘液 / 蛋白発現 / タンパク質発現 / マウス個体 / タンパク発現 / 遺伝子導入 / HVJ-エンベロープ / TFF3ペプチド / enteric flora / elemental diet / mucosal immune system / - mice / TCR α- / inflammatory bowel disease / 腸内細菌叢 / 成分栄養 / 食餌抗原 / TCRα鎖欠損マウス / 炎症性腸疾患 / Mucosal cytokine / mutant CT / Mucosal adjuvant / Secretory IgA / Mucosal vaccine / 粘膜アジュバンド / 経鼻ワクチン / 無毒化変異型CT / 粘膜免疫システム / B-2 cells / B-1 / Peyer's patch / Mucosal T cells / Epithelial cell / Mucosal intranet / 上皮細胞 / γδT細胞 / IL-7R / IL-7 / コレラ毒素 / 上皮細胞間リンパ球 / IL-10 / TCRδ遺伝子欠損マウス / 粘膜系γδT細胞 / 経口免疫寛容 / 粘膜誘導型寛容 / 粘膜免疫機構 / 粘膜細胞間イントラネット / 粘膜細胞間インターネット / 粘膜細胞イントラネット / CMIS独立型 / IL-15 / IL-5 / B-1細胞 / CMIS / パイエル板 / Mucosal Th2 / Mucosal Th1 / Mucosal Adjuvant / Mucosal Modulator / Mucosal Intranet / Mucosal Vaccine / Mucosal Immune System / レベル2 Th2型 / Th2型応答 / Th1型 / IFN-γ遺伝子欠損マウス / 経口免疫 / 無毒化リコンビナントサルモネラ菌 / Th2型細胞 / Th1型細胞 / bacteriocin / Streptococcus sobrinas / dental caries / mutacin / う触 / バクテリオシン / ミュータシン / Tyrosine Protein Phosphorylation / murine B lymphocytes / Host responses / Periodontopathic bacteria / Endotoxin (lipopolysaccharide) / 歯周炎 / シグナル伝達 / HeJマウス / C3H / 線維芽細胞 / 表面抗原 / LPS / 内毒素 / 歯周病原菌 / Porphyromomas gingivalis / チロシンリン酸化反応 / マウスBリンパ球 / 宿主反応 / 歯周病原性細菌 / 細菌内毒素 Less

微生物細胞内共生現象の分子機構の生体エネルギー論的展開Principal Investigator
- Principal Investigator
  
  高橋一郎
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49070:Immunology-related
- Research Institution
  Hiroshima University
Molecular basis of host-microbe symbiosis within tissue resident macrophagesPrincipal Investigator
- Principal Investigator
  
  takahashi ichiro
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57020:Oral pathobiological science-related
- Research Institution
  Hiroshima University
A novel mucosal immunomodulator MICA for homeostasis of the mucosal immune systemPrincipal Investigator
- Principal Investigator
  
  TAKAHASHI Ichiro
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  HIROSHIMA UNIVERSITY
The development of the vaccine for periodontal disease with using HVJ-envelope
- Principal Investigator
  
  TSURUDA Keiko
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Social dentistry
- Research Institution
  Hiroshima University
胸腺外分化T細胞の生理的リガンドの探索と感染防御における病因論的役割の解析Principal Investigator
- Principal Investigator
  
  高橋一郎
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Hiroshima University
胸腺外分化T細胞の生理的リガンドの探索と感染防御における病因論的役割の解析Principal Investigator
- Principal Investigator
  
  高橋一郎
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University
Molecular biology of extrathymic T cells for the development of mucosal inflammationPrincipal Investigator
- Principal Investigator
  
  TAKAHASHI Ichiro
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  OSAKA UNIVERSITY
Characterization of Novel Mucosal Modulator for IgA
- Principal Investigator
  
  KIYONO Hiroshi
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Immunology
- Research Institution
  Osaka University
Molecular biology of oligoclonal ββィイD1+ィエD1 T cells in murine inflammatory bowel diseasePrincipal Investigator
- Principal Investigator
  
  TAKAHASHI Ichiro
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  Osaka University
A study of the environmental factors for the development of inflammatory bowel disease
- Principal Investigator
  
  INOUE Yoshifumi
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  Osaka University
Characterization of mucosal intranet formed by γδ/αβ T cells and epithelial cells
- Principal Investigator
  
  KIYONO Hiroshi
- Project Period (FY)
  1997 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (A).
- Research Field
  
  Immunology
- Research Institution
  Osaka University
T細胞受容体欠損マウスを用いた経口免疫寛容の分子メカニズムの解明Principal Investigator
- Principal Investigator
  
  高橋一郎
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Osaka University
Mucosal Vaccines : Vectors and Adjuvants for Novel Th1 and Th2 cells
- Principal Investigator
  
  KIYONO Hiroshi
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Field
  
  Immunology
- Research Institution
  Osaka University
細胞感染に起因する粘膜免疫の細胞生物学的研究Principal Investigator
- Principal Investigator
  
  高橋一郎
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Osaka University
粘膜免疫誘導エピトープのマッピングPrincipal Investigator
- Principal Investigator
  
  高橋一郎
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Osaka University
Development of mutacin MT6223 from Streptococcus sobrinus as an anti-caries agent
- Principal Investigator
  
  HAMADA Shigeyuki
- Project Period (FY)
  1994 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  病態科学系歯学(含放射線系歯学)
- Research Institution
  Osaka University
Bacterial endotoxic substances from periodontopathic bacteria and their effects on host cells
- Principal Investigator
  
  HAMADA Shigeyuki
- Project Period (FY)
  1993 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Osaka University
Development of Anti-Dental Caries Vaccine Using Recombinant Lactic Streptococci
- Principal Investigator
  
  KOGA Toshihiko
- Project Period (FY)
  1988 – 1990
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B).
- Research Field
  
  小児・社会系歯学
- Research Institution
  National Institute of Health

All 2022 2019 2006 2005 2004

All Journal Article Book

[Book] 口腔微生物学・免疫学第2版:第2章8:粘膜免疫2005
- Author(s)
  高橋一郎
- Total Pages
  348
- Publisher
  医歯薬出版
- Data Source
  KAKENHI-PROJECT-16590406
[Journal Article] Oral administration of bovine lactoferrin suppresses the progression of rheumatoid arthritis in an SKG mouse model2022
- Author(s)
  Yanagisawa, A., K. Nagasaki, I. Takahashi, M. Miyauchi, T. Takata, et al.
- Journal Title
  
  PLOS ONE
  
  Volume: 17 (2) Issue: 2 Pages: e0263254-e0263254
- DOI
  10.1371/journal.pone.0263254
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K10088
[Journal Article] Analysis of hypoxia-associated dendritic cells in colitic mice and effects of probiotics on IL-10 production in inflammatory dendritic-cells under hypoxia2019
- Author(s)
  Ogita T, Miyamoto J, Hirabayashi Y, Rossi M, Mazzarella G, Takahashi I, Tanabe S, Suzuki T.
- Journal Title
  
  Beneficial Microbes
  
  Volume: 10 Issue: 7 Pages: 801-810
- DOI
  10.3920/bm2018.0171
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K10088
[Journal Article] Persistent colonization of non-lymphoid tissue-resident macrophages by Stenotrophomonas maltophilia2019
- Author(s)
  Takahashi Ichiro, Hosomi Koji, Nagatake Takahiro, Tobou Hirokazu, Yamamoto Daiki, Hayashi Ikue, Kurashima Yosuke, Sato Shintaro, Shibata Naoko, Goto Yoshiyuki, Maruyama Fumito, Nakagawa Ichiro, Kuwae Asaomi, Abe Akio, Kunisawa Jun, Kiyono Hiroshi
- Journal Title
  
  International Immunology
  
  Volume: 32 Issue: 2 Pages: 133-141
- DOI
  10.1093/intimm/dxz071
- NAID
  120006888456
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07542, KAKENHI-PROJECT-19K10088, KAKENHI-PROJECT-19K22532, KAKENHI-PROJECT-18K17997, KAKENHI-PROJECT-18KK0193, KAKENHI-PROJECT-16H01782, KAKENHI-PROJECT-18H02674, KAKENHI-PROJECT-19H03465, KAKENHI-PROJECT-19H03471, KAKENHI-PROJECT-19H03702, KAKENHI-PROJECT-17K08838, KAKENHI-PROJECT-17K17686, KAKENHI-PROJECT-18H05280, KAKENHI-PROJECT-17J07480, KAKENHI-PROJECT-19H03450
[Journal Article] 粘膜免疫システムの光と影2006
- Author(s)
  高橋一郎
- Journal Title
  
  日本ヘリコバクター学会誌 7
  
  Pages: 62-69
- Data Source
  KAKENHI-PROJECT-16590406
[Journal Article] Secretory IgA immune responses as the mucosal frontline.2006
- Author(s)
  Takahashi, I., Sasaki, A., Kiyono H.
- Journal Title
  
  Proceedings of Hiroshima Conference on Education and Science in Dentistry
  
  Pages: 55-64
- Data Source
  KAKENHI-PROJECT-16590406
[Journal Article] 粘膜免疫システムの光と影2006
- Author(s)
  高橋一郎
- Journal Title
  
  日本ヘリコバクター学会誌 7
  
  Pages: 62-69
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590406
[Journal Article] Yin and yang of the mucosal immune system.2006
- Author(s)
  Takahashi, I.
- Journal Title
  
  Japanese Journal of Helicobacter Research. 7
  
  Pages: 62-69
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590406
[Journal Article] Secretory IgA responses as the mucosal frontline.2006
- Author(s)
  Takahashi, I., Sasaki, A., Kiyono, H.
- Journal Title
  
  Proceedings of Hiroshima Conference on Education and Science. 2006
  
  Pages: 55-64
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590406
[Journal Article] Secretory IgA responses as the mucosal frontline.2006
- Author(s)
  Takahashi, I., Sasaki, A., Kiyono, H.
- Journal Title
  
  Proceedings of Hiroshima Conference on Education and Science Dentistry 2006.
  
  Pages: 55-64
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590406
[Journal Article] 粘膜ウクチンの実用化に向けて2005
- Author(s)
  佐々木淳, 岩本めぐみ, 山本健太, 清野宏, 高橋二郎
- Journal Title
  
  臨床と微生物 32
  
  Pages: 283-288
- Data Source
  KAKENHI-PROJECT-16590406
[Journal Article] ストレス誘導タンパクMICA分子による腸管免疫制御2005
- Author(s)
  鶴田圭伊子, 高橋一郎
- Journal Title
  
  BIO Clinica 20
  
  Pages: 494-499
- Data Source
  KAKENHI-PROJECT-16590406
[Journal Article] Colitis in mice lacking the common cytokine receptor gamma chain is mediated by IL-6-producing CD4+ T cells.2005
- Author(s)
  Kai, Y., Takahashi, I., et al.
- Journal Title
  
  Gastroenterology (印刷中)
- Data Source
  KAKENHI-PROJECT-16590406
[Journal Article] Colitis in mice lacking common cytokine receptor gamma chain is mediated by IL-6 producing CD4+T cells.2005
- Author(s)
  Kai, Y., Takahashi, I., et al.
- Journal Title
  
  Gastroenterology 128
  
  Pages: 922-938
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590406
[Journal Article] 粘膜ワクチン2005
- Author(s)
  高橋一郎
- Journal Title
  
  アニムス 10巻
  
  Pages: 28-31
- Data Source
  KAKENHI-PROJECT-16590406
[Journal Article] Colitis in mice lacking common cytokine receptor gamma chain is mediated by IL-6 producing CD4+ T cells.2005
- Author(s)
  Kai, Y., Takahashi, I., et al.
- Journal Title
  
  Gastroenterology 128
  
  Pages: 922-938
- Data Source
  KAKENHI-PROJECT-16590406
[Journal Article] 粘膜ワクチン2005
- Author(s)
  高橋一郎, 柳原琢磨
- Journal Title
  
  日本臨床 63
  
  Pages: 468-473
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590406
[Journal Article] Colitis in mice lacking common cytokine receptor gamma chain is mediated by IL-6 producing CD4+T cells.2005
- Author(s)
  Kai, Y., Takahashi, I., Hiroi, T., Kiyono, H.
- Journal Title
  
  Gastroenterology 128
  
  Pages: 922-938
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590406
[Journal Article] Mucosal vaccine.2005
- Author(s)
  Takahashi, I., Yanagihara, T.
- Journal Title
  
  Nippon Rinsho. 63
  
  Pages: 468-473
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590406
[Journal Article] 予防接種の免疫学2004
- Author(s)
  高橋一郎
- Journal Title
  
  総合臨床 53巻
  
  Pages: 1830-1833
- Data Source
  KAKENHI-PROJECT-16590406
[Journal Article] 経粘膜ワクチン2004
- Author(s)
  高橋一郎
- Journal Title
  
  Biotherapy 18巻
  
  Pages: 43-49
- Data Source
  KAKENHI-PROJECT-16590406

1. KIYONO Hiroshi (10271032)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
2. HIROI Takachika (80228824)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
3. YAMAMOTO Masafumi (80210558)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. HAMADA Shigeyuki (60028777)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. FUJIWARA Taku (00228975)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. 島岡要 (40281133)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. FUJIHASHI Kuhtaro

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. MCGHEE Jerry

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. KIMURA Shigenobu (10177917)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. OOSHIMA Takashi (80116003)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. KWEON Mi-na (80324846)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. INOUE Yoshifumi (10294076)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. TSURUDA Keiko (10112210)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. KOGA Toshihiko (10037541)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. OKAHASHI Nobuo (40150180)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 森崎市治郎 (30116115)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. TANAKA Takaharu

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. OHTA Hirotaka

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. VANCOTT John

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 阿部章夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Takahashi Ichiro 高橋 一郎

takahashi ichiro 高橋 一郎

TAKAHASHI Ichiro 高橋 一郎

Research Projects

Research Products

Co-Researchers

微生物細胞内共生現象の分子機構の生体エネルギー論的展開Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Molecular basis of host-microbe symbiosis within tissue resident macrophagesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

A novel mucosal immunomodulator MICA for homeostasis of the mucosal immune systemPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

胸腺外分化T細胞の生理的リガンドの探索と感染防御における病因論的役割の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

胸腺外分化T細胞の生理的リガンドの探索と感染防御における病因論的役割の解析Principal Investigator

Principal Investigator

Project Period (FY)

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Review Section

Research Institution

Molecular biology of extrathymic T cells for the development of mucosal inflammationPrincipal Investigator

Principal Investigator

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Principal Investigator

Project Period (FY)

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Molecular biology of oligoclonal ββィイD1+ィエD1 T cells in murine inflammatory bowel diseasePrincipal Investigator

Principal Investigator

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Research Institution

Principal Investigator

Project Period (FY)

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Research Field

Research Institution

Principal Investigator

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T細胞受容体欠損マウスを用いた経口免疫寛容の分子メカニズムの解明Principal Investigator

Principal Investigator

Project Period (FY)

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Research Field

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Principal Investigator

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細胞感染に起因する粘膜免疫の細胞生物学的研究Principal Investigator

Takahashi Ichiro 高橋一郎

takahashi ichiro 高橋一郎

TAKAHASHI Ichiro 高橋一郎

[Book] 口腔微生物学・免疫学第2版:第2章8:粘膜免疫2005