Sasaki Yasutsuna 佐々木康綱

… Alternative Names

SASAKI Yasutsuna 佐々木康綱

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Researcher Number	20235279
Affiliation (Current)	2025: 昭和大学, 医学部, 客員教授
Affiliation (based on the past Project Information) *help	2016 – 2018: 昭和大学, 医学部, 教授 2013: 埼玉医科大学, 医学部, 教授 2012 – 2013: 昭和大学, 医学部, 教授 2010 – 2011: 埼玉医科大学, 医学部, 教授 2007 – 2008: 埼玉医科大学, 医学部, 教授 … More 2006: Saitama Medical School, Department of Clinical Oncology, Professor, 臨床腫瘍科, 教授 2005: 埼玉医科大学, 医学部, 教授 2004: 埼玉医学大学, 附属病院, 教授 Less
Review Section/Research Field	Except Principal Investigator Applied pharmacology / Medical pharmacy / Respiratory organ internal medicine / Medical systems
Keywords	Except Principal Investigator 遺伝子多型 / イリノテカン / 薬物動態 / 蛋白結合 / 肝消失型抗がん薬 / 尿毒素 / SN-38 / 塩酸イリノテカン / 個別化医療 / UGT1A1 … More / 遊離形 / イリノテカン塩酸塩 / long-lasting inhibition / indole / 肝代謝型 / 投与設計 / PBPKモデル / 腎機能障害 / 慢性閉塞性肺疾患 / COPD / 発癌 / TNF / EGFR / 腫瘍壊死因子 / 上皮成長因子受容体 / 肺癌 / search / drug adverse reaction / data base / grid computing / individual medicine / polymorphism / anti-cancer drug / pharmacokinetics / 個別化治療 / パスウエイ解析 / CeLLML / SNP / データウエアハウス / シミュレーション / バーチャルフェーズI / テーラーメイド医療 / 化学療法 / 抗がん剤 / がん / 探索 / 薬剤副作用 / データベース / グリッドコンピューティング / 抗癌剤 / 薬物動態解析 / 人種差 / VKORC12 / CYP2C98 / CYP2C9*3 / INR / VKORC1 / CYP2C9 / 応答性 / 個体差 / ワルファリン / ファーマコゲノミクス / トランスポーター / 体内動態 / 腎不全 / 尿毒症物質 / 腎機能 / 排出遅延 / 肝消失型 / 発現低下 / OATP1B1 / 腎機能低下 / 排泄遅延 / ABCC2 / UGTIA1 / 用量調節試験 / 副作用 / 大腸癌 / ゲノム薬理学 / 臨床薬理学 / ヒト組織利用研究 / 薬力 / 緩和医療 / がん疼痛 / UGT2B7 / OPRM1 / ABCB1 / 薬物有害反応 / 薬理遺伝学 / モルヒネ Less

Investigate the role of TNF and EGFR in the onset and progression of lung cancer complicated with COPD
- Principal Investigator
  
  Yamaoka Toshimitsu
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Showa University
Mechanisms of delayed elimination and decreased plasma protein binding of anticancer drugs which are mainly eliminated via the liver in cancer patients with severe renal failure
- Principal Investigator
  
  Fujita Ken-ichi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Showa University
Mechanism for the delayed elimination of SN-38 in cancer patients with severe renal failure and optimal treatment strategy
- Principal Investigator
  
  FUJITA Ken-ichi
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Showa University
  Saitama Medical University
Association of pharmacokinetics or pharmacogenomics with toxicity of erlotinib in patients with advanced non-small cell lung cancer
- Principal Investigator
  
  HIROSE Takashi
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied pharmacology
- Research Institution
  Tokyo National Hospital (Clinical research)
  Showa University
Establishment of pharmacogenetic-based dosing algorithm of warfarin for Asian, Caucasian and African American patients
- Principal Investigator
  
  TAKAHASHI Harumi
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied pharmacology
- Research Institution
  Meiji Pharmaceutical University
Phase I/II study of irinotecan plus infusional 5-fluorouracil/leucovorin (FOLFIRI) in Japanese patients with advanced colorectal cancer and genetic testing for UDP-glucuronosyltransferase (UGT) 1A1*28 and *6.
- Principal Investigator
  
  NAGASHIMA Fumio
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied pharmacology
- Research Institution
  Saitama Medical University
Factors causing interindividual variability in response to morphine
- Principal Investigator
  
  FUJITA Ken-ichi
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied pharmacology
- Research Institution
  Saitama Medical University
Development of clinical genome information systems for pharmacokinetics analysis
- Principal Investigator
  
  OYAMA Hiroshi
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Medical systems
- Research Institution
  The University of Tokyo

[Book] 抗悪性腫瘍薬.医系薬理学改訂2版(遠藤仁,橋本敬太郎,後藤勝年,金井好克編)2005
- Author(s)
  安藤雄一, 佐々木康綱
- Publisher
  中外医学社
- Data Source
  KAKENHI-PROJECT-16200038
[Journal Article] Distinct Afatinib Resistance Mechanisms Identified in Lung Adenocarcinoma Harboring an EGFR Mutation.2017
- Author(s)
  Yamaoka T, Ohmori T, Ohba M, Arata S, Murata Y, Kusumoto S, Ando K, Ishida H, Ohnishi T, Sasaki Y.
- Journal Title
  
  Mol Cancer Res.
  
  Volume: 7 Pages: 915-928
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09590
[Journal Article] The acquired resistant mechanisms for sequential treatment of EGFR-TKI to Met-TKI/EGFR-TKI in a Met amplified EGFR-TKI resistant lung adenocarcinoma cells, harboring EGFR activating mutation.2016
- Author(s)
  64.Yamaoka T., Ohmori T., Ohba M., Arata S., Kishino Y., Murata Y., Kusumoto S., Ishida H., Shirai T., Hirose T., Ohnishi T., and Sasaki Y.
- Journal Title
  
  Mol. Cancer Ther.
  
  Volume: 15 Issue: 12 Pages: 3040-3054
- DOI
  10.1158/1535-7163.mct-16-0313
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460153, KAKENHI-PROJECT-16K09590
[Journal Article] Increased plasma concentrations of unbound SN-38, the active metabolite of irinotecan, in cancer patients with severe renal failure2016
- Author(s)
  Ken-ichi Fujita, Yusuke Masuo, Hidenori Okumura, Yusuke Watanabe, Hiromichi Suzuki, Yu Sunakawa, Ken Shimada, Kaori Kawara, Yuko Akiyama, Masanori Kitamura, Munetaka Kunishima, Yasutsuna Sasaki, Yukio Kato
- Journal Title
  
  Pharmaceutical Research
  
  Volume: 33 Issue: 2 Pages: 269-282
- DOI
  10.1007/s11095-015-1785-0
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26460205, KAKENHI-PROJECT-15H04664, KAKENHI-PROJECT-26860099
[Journal Article] Optimization of cancer chemotherapy on the basis of pharmacokinetics and pharmacodynamics : from patients enrolled in clinical trials to those in the 'real world'2014
- Author(s)
  Fujita K, Sasaki Y
- Journal Title
  
  Drug Metab Pharmacokinet
  
  Volume: 29 Pages: 20-8
- NAID
  130004463350
- URL
  https://www.jstage.jst.go.jp/browse/dmpk/29/0/_contents
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590198
[Journal Article] Optimization of cancer chemotherapy on the basis of pharmacokinetics and pharmacodynamics: from patients enrolled in ‘clinical trials’ to those in the ‘real world’2014
- Author(s)
  Ken-ichi Fujita, Yasutsuna Sasaki
- Journal Title
  
  Drug Metabolism and Pharmacokinetics
  
  Volume: 29 Pages: 20-28
- NAID
  130004463350
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590198
[Journal Article] Direct inhibition and down-regulation by uremic plasma components of hepatic uptake transporter for SN-38, an active metabolite of irinotecan, in humans2014
- Author(s)
  Fujita K, Sasaki Y, Kato Y(他9名)
- Journal Title
  
  Pharm Res
  
  Volume: 31 Issue: 1 Pages: 204-15
- DOI
  10.1007/s11095-013-1153-x
- NAID
  120005385991
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590198, KAKENHI-PROJECT-24390040, KAKENHI-PROJECT-25460092
[Journal Article] Phase I/II study of FOLFIRI in Japanese patients with advanced colorectal cancer.2011
- Author(s)
  Yamashita K, Nagashima F, Fujita K, Yamamoto W, Endo H, Miya T, Narabayashi M, Kawara K, Akiyama Y, Ando Y, Ando M, Sasaki Y.
- Journal Title
  
  Jpn J Clin Oncol 41
  
  Pages: 204-209
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590546
[Journal Article] Naチャネル遺伝子多型と神経障害予測による大腸癌薬物療法の新しい投与法の開発2010
- Author(s)
  佐々木康綱
- Journal Title
  
  埼玉医科大学雑誌 36
  
  Pages: 125-127
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590546
[Journal Article] UGT1A1*1/*28 and *1/*6 genotypes have no effects on the efficacy and toxicity of FOLFIRI in Japanese patients with advanced colorectal cancer.2010
- Author(s)
  Sunakawa Y, Ichikawa W, Fujita KI, Nagashima F, Ishida H, Yamashita K, Mizuno K, Miwa K, Kawara K, Akiyama Y, Araki K, Yamamoto W, Miya T, Narabayashi M, Ando Y, Hirose T, Saji S, Sasaki Y.
- Journal Title
  
  Cancer Chemother Pharmacol in press
- Data Source
  KAKENHI-PROJECT-20590546
[Journal Article] Association of UGT2B7 and ABCB1 genotypes with morphine-induced adverse drug reactions in Japanese patients with cancer2009
- Author(s)
  FujitaKen-ichi、Ando Yuichi、Yamamoto Wataru、Miya Toshimichi、Endo Hisashi、Sunakawa Yu、Araki Kazuhiro、Kodama Keiji、Nagashima Fumio、Ichikawa Wataru、 Narabayashi Masaru 、Akiyama Yuko 、Kawara Kaori 、Shiomi Mari 、Ogata Hiroyasu 、Iwasa Hiroyasu 、Okazaki Yasushi 、Hirose Takashi 、Sasaki Yasutsuna
- Journal Title
  
  Cancer Chemotherapy and Pharmacology in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590542
[Journal Article] Association of ATP-binding cassette, sub-family C, number 2 (ABCC2) genotype with pharmacokinetics of irinotecan in Japanese patients with metastatic colorectal cancer treated with irinotecan plus infusional 5-fluorouracil/leucovorin (FOLFIRI).2008
- Author(s)
  Fujita K, Nagashima F, Yamamoto W, Endo H, Sunakawa Y, Yamashita K, Ishida H, Mizuno K, Matsunaga M, Araki K, Tanaka R, Ichikawa W, Miya T, Narabayashi M, Akiyama Y, Kawara K, Ando Y, Sasaki Y.
- Journal Title
  
  Biol Pharm Bull 31
  
  Pages: 2137-2142
- NAID
  110006968101
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590546
[Journal Article] Genetic testing for UGT1A1*28 and *6 in Japanese patients who receive irinotecan chemotherapy.2008
- Author(s)
  Akiyama Y, Fujita K, Nagashima F, Yamamoto W, Endo H, Sunakawa Y, Yamashita K, Ishida H, Mizuno K, Araki K, Ichikawa W, Miya T, Narabayashi M, Kawara K, Sugiyama M, Hirose T, Ando Y, Sasaki Y.
- Journal Title
  
  Ann Oncol 19
  
  Pages: 2089-2090
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590546
[Journal Article] Genetic linkage of UGT1A7 and UGT1A9 polymorphisms to UGT1A1^*6 is associated with reduced glucuronidase acitivity for SN-38 in Japanese patients with cancer.2007
- Author(s)
  Fujita K, Ando Y, Nagashima F, Yamamoto W, Eodo H, Araki K, Kodama K, Miya T, Narabayashi M, Sasaki Y
- Journal Title
  
  Cancer Chemother Pharmacol (in press)
- Data Source
  KAKENHI-PROJECT-16200038
[Journal Article] Pharmacogenetic impact of polymorphisms in the coding region of the UGT1A1 gene on SN-38 glucuronidation in Japanese patients with cancer.2006
- Author(s)
  Araki K, Fujita K, Ando Y, Nagashima F, Yamamoto W, Endou H, Miya T, Kodama K, Narabayashi M, Sasaki Y.
- Journal Title
  
  Cancer Sci 97
  
  Pages: 1255-9
- NAID
  10019377373
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16200038
[Journal Article] Novel single nucleotide polymorphism of UGT1A7 gene in Japanese.2006
- Author(s)
  Fujita K, Ando Y, Nagashima F, Yamamoto W, Eodo H, Araki K, Kodama K, Araki K, Miya T, Narabayashi M, Sasaki Y
- Journal Title
  
  Drug Metab Pharmacokinet. 21
  
  Pages: 75-8
- NAID
  10017318038
- Data Source
  KAKENHI-PROJECT-16200038
[Journal Article] Novel single nucleotide polymorphism of UGT1A9 gene in Japanese.2006
- Author(s)
  Fujita K, Ando Y, Nagashima F, Yamamoto W, Eodo H, Araki K, Kodama K, Araki K, Miya T, Narabayashi M, Sasaki Y
- Journal Title
  
  Drug Metab Pharmacokinet. 21
  
  Pages: 79-81
- NAID
  10017318060
- Data Source
  KAKENHI-PROJECT-16200038
[Journal Article] Novel single nucleotide polymorphism of UGT1A7 gene in Japanese.2006
- Author(s)
  Fujita K, Ando Y, Nagashima F, Yamamoto W, Endo H, Kodama K, Araki K, Miya T, Narabayashi M, Sasaki Y.
- Journal Title
  
  Drug Metab Pharmacokinet. 21
  
  Pages: 75-8
- NAID
  10017318038
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16200038
[Journal Article] Novel single nucleotide polymorphism of UGT1A9 gene in Japanese.2006
- Author(s)
  Fujita K, Ando Y, Nagashima F, Yamamoto W, Endo H, Kodama K, Araki K, Miya T, Narabayashi M, Sasaki Y
- Journal Title
  
  Drug Metab Pharmacokinet. 21
  
  Pages: 79-81
- NAID
  10017318060
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16200038
[Journal Article] Novel single nucleotide polymorphism of UGT1A9 gene in Japanese.2006
- Author(s)
  Fujita K, Ando Y, Nagashima F, Yamamoto W, Endo H, Kodama K, Araki K, Miya T, Narabayashi M, Sasaki Y.
- Journal Title
  
  Drug Metab Pharmacokinet. 21
  
  Pages: 79-81
- NAID
  10017318060
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16200038
[Journal Article] Novel single nucleotide polymorphism of UGT1A7 gene in Japanese.2006
- Author(s)
  Fujita K, Ando Y, Nagashima F, Yamamoto W, Endo H, Kodama K, Araki K, Miya T, Narabayashi M, Sasaki Y
- Journal Title
  
  Drug Metab Pharmacokinet. 21
  
  Pages: 75-78
- NAID
  10017318038
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16200038
[Journal Article] Pharmacogenetic impact of polymorphisms in the coding region of the UGT1A1 gene on SN-38 glucuronidation in Japanese patients with cancer.2006
- Author(s)
  Araki K, Fujita K, Ando Y, Nagashima F, Yamamoto W, Endou H, Miya T, Kodama K, Narabayashi M, Sasaki Y
- Journal Title
  
  Cancer Sci. 97
  
  Pages: 1255-1259
- NAID
  10019377373
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16200038
[Journal Article] Gefitinib (Iressa) inhibits the CYP3A4-mediated formation of NPC, but activates that of APC from irinotecan.2005
- Author(s)
  Ken-ichi Fujita, Yuichi Ando, Masaru Narabayashi, Toshimichi Miya, Fumio Nagashima, Wataru Yamamoto, Keiji Kodama, Kazuhiro Araki, Hisashi Endo, Yasutsuna Sasaki.
- Journal Title
  
  Drug Metab Dispos 33
  
  Pages: 1785-1790
- Data Source
  KAKENHI-PROJECT-16200038
[Journal Article] CellMLを基にした薬物動態モデリング2005
- Author(s)
  白潟宏之, 安藤雄一, 倉田正, 佐々木康綱, 小山博史
- Journal Title
  
  第6回日本医療情報学会学術大会論文誌 5(2)
  
  Pages: 24-26
- Data Source
  KAKENHI-PROJECT-16200038
[Journal Article] 抗がん剤のファーマコジェノミクス2004
- Author(s)
  安藤雄一, 佐々木康綱
- Journal Title
  
  血液・腫瘍科 48・2
  
  Pages: 162-166
- Data Source
  KAKENHI-PROJECT-16200038
[Journal Article] Genetic linkage of UGT1A7 and UGT1A9 polymorphisms to UGT1A1*6 is associated with reduced glucuronidase activity for SN-38 in Japanese patients with cancer.
- Author(s)
  Fujita K, Ando Y, Nagashima F, Yamamoto W, Eodo H, Araki K, Kodama K, Miya T, Narabayashi M, Sasaki Y.
- Journal Title
  
  Cancer Chemother Pharmacol (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16200038
[Journal Article] Genetic linkage of UGT1A7 and UGT1A9 polymorphisms to UGT1A1^*6 is associated with reduced glucuronidase activity for SN-38 in Japanese patients with cancer.
- Author(s)
  Fujita K, Ando Y, Nagashima F, Yamamoto W, Eodo H, Araki K, Kodama K, Miya T, Narabayashi M, Sasaki Y
- Journal Title
  
  Cancer Chemother Pharmacol (in press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16200038
[Presentation] レゴラフェニブと活性代謝物の体内動態解析とABC輸送担体の関与2016
- Author(s)
  藤田健一，増尾友佑，山崎絵里名，澁谷俊紀，中道範高，佐々木康綱，加藤将夫
- Organizer
  第37回日本臨床薬理学会学術総会
- Place of Presentation
  米子
- Year and Date
  2016-12-01
- Data Source
  KAKENHI-PROJECT-26460205
[Presentation] Mechanism underlying acquisition of dual resistance to EGFR and MET inhibitors by EGFR-mutant lung adenocarcinoma cells2016
- Author(s)
  Yamaoka T, Ohmori T, Ohba M, Kishino Y, Murata Y, Kusumoto S, Ishida H, Ohnishi T, Sasaki Y.
- Organizer
  AACR
- Place of Presentation
  ニューオリンズ・米国
- Year and Date
  2016-04-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09590
[Presentation] EGFR-Mutationを伴う肺腺癌細胞株におけるEGFR-TKIとMET-TKIへの獲得耐性機序2016
- Author(s)
  山岡利光, 大森亨, 大場基, 村田泰規, 楠本壮二郎, 石田博雄, 佐々木康綱
- Organizer
  日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2016-10-07
- Data Source
  KAKENHI-PROJECT-16K09590
[Presentation] Involvement of ABC drug transporters in disposition of active metabolites of tyrosine kinase inhibitor regorafenib2016
- Author(s)
  Erina Yamazaki, Yusuke Masuo, Ken-ichi Fujita, Toshiki Shibutani, Noritaka Nakamichi, Yasutsuna Sasaki, Yukio Kato
- Organizer
  31st Japanese Society for the Study of Xenobiotics annual meeting
- Place of Presentation
  松本
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-26460205
[Presentation] Mechanism underlying acquisition of dual resistance to EGFR and MET inhibitors by EGFR-mutant lung adenocarcinoma cells2016
- Author(s)
  山岡利光, 大森亨, 大場基, 村田泰規, 楠本壮二郎, 石田博雄, 佐々木康綱
- Organizer
  臨床腫瘍学会
- Place of Presentation
  神戸
- Year and Date
  2016-07-28
- Data Source
  KAKENHI-PROJECT-16K09590
[Presentation] Inhibition of human hepatic transporter OATP1B1 by indole metabolites2016
- Author(s)
  Natsumi Seba, Yusuke Masuo, Ken-ichi Fujita, Noritaka Nakamichi, Yasutsuna Sasaki, Yukio Kato
- Organizer
  31st Japanese Society for the Study of Xenobiotics annual meeting
- Place of Presentation
  松本
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-26460205
[Presentation] 極めて腎機能の低下したがん患者におけるイリノテカン塩酸塩の至適投与量の推定2015
- Author(s)
  藤田健一，増尾友祐，奥村英典，佐々木康綱，加藤将夫
- Organizer
  第36回日本臨床薬理学会学術総会
- Place of Presentation
  東京
- Year and Date
  2015-12-09
- Data Source
  KAKENHI-PROJECT-26460205
[Presentation] Appropriate dose of irinotecan in cancer patients with severe renal failure (SRF)2015
- Author(s)
  Ken-ichi Fujita, Yusuke Masuo, Hidenori Okumura, Yasutsuna Sasaki and Yukio Kato
- Organizer
  The 12nd Japanese Society of Medical Oncology annual meeting
- Place of Presentation
  Sapporo
- Year and Date
  2015-07-16
- Data Source
  KAKENHI-PROJECT-26460205
[Presentation] Long-lasting inhibition of organic anion transporting polypeptide (OATP) 1B1 by endogenous uremic toxin indoxyl sulfate2015
- Author(s)
  Tatsuya Kogi, Yusuke Masuo, Ken-ichi Fujita, Masanori Kitamura, Noritaka Nakamichi, Yasutsuna Sasaki, Munetaka Kunishima, Yukio Kato
- Organizer
  30th Japanese Society for the Study of Xenobiotics annual meeting
- Place of Presentation
  Tokyo
- Year and Date
  2015-11-12
- Data Source
  KAKENHI-PROJECT-26460205
[Presentation] OATP1B1-mediated hepatic uptake of SN-38, an active metabolite of irinotecan, and its inhibition by uremic toxins in humans2013
- Author(s)
  Fujita K, Sugiura T, Okumura H, Umeda S, Nakamichi N, Sasaki Y, Kato Y
- Organizer
  114^<th> American Society for Clinical Pharmacology and Therapeutics annual meeting
- Place of Presentation
  Indianapolis
- Data Source
  KAKENHI-PROJECT-23590198
[Presentation] Direct Inhibition and Down-regulation by Uremic Plasma Components of Hepatic Uptake Transporter for SN-38, an Active Metabolite of Irinotecan, in Humans2013
- Author(s)
  Hidenori Okumura, Ken-ichi Fujita, Yusuke Masuo, Tomoko Sugiura, Noritaka Nakamichi, Yusuke Watanabe, Hiromichi Suzuki, Yu Sunakawa, Ken Shimada, Kaori Kawara, Yasutsuna Sasaki, Yukio Kato
- Organizer
  28th Japanese Society for the Study of Xenobiotics annual meeting
- Place of Presentation
  Tokyo
- Data Source
  KAKENHI-PROJECT-23590198
[Presentation] Down-regulation by uremic plasma components of hepatic uptake transporter for SN-38 in humans2013
- Author(s)
  Ken-ichi Fujita, Noritaka Nakamichi, Yu Sunakawa, Ken Shimada, Kaori Kawara, Yasutsuna Sasaki, Yukio Kato
- Organizer
  72nd Japan Cancer Association meeting
- Place of Presentation
  Yokohama
- Data Source
  KAKENHI-PROJECT-23590198
[Presentation] Direct Inhibition and Down-regulation by Uremic Plasma Components of Hepatic Uptake Transporter for SN-38, an Active Metabolite of Irinotecan, in Humans2013
- Author(s)
  Okumura H, Fujita K, Masuo Y, Sugiura T, Nakamichi N, Watanabe Y, Suzuki H, Sunakawa Y, Shimada K, Kawara K, Sasaki Y, Kato Y
- Organizer
  28^<th> Japanese Society for the Study of Xenobiotics annual meeting
- Place of Presentation
  Tokyo
- Data Source
  KAKENHI-PROJECT-23590198
[Presentation] Down-regulation by uremic plasma components of hepatic uptake transporter for SN-38 in humans2013
- Author(s)
  Fujita K, Nakamichi N, Sunakawa Y, Shimada K, Kawara K, Sasaki Y, Kato Y
- Organizer
  72^<nd> Japan Cancer Association meeting
- Place of Presentation
  Yokohama
- Data Source
  KAKENHI-PROJECT-23590198
[Presentation] OATP1B1-mediated hepatic uptake of SN-38, an active metabolite of irinotecan, and its inhibition by uremic toxins in humans2013
- Author(s)
  Ken-ichi Fujita, Tomoko Sugiura, Hidenori Okumura, Saki Umeda, Noritaka Nakamichi, Yasutsuna Sasaki, Yukio Kato
- Organizer
  114th American Society for Clinical Pharmacology and Therapeutics annual meeting
- Place of Presentation
  Indianapolis, USA
- Data Source
  KAKENHI-PROJECT-23590198
[Presentation] Involvement of OATP and inhibition by uremic toxins in hepatic uptake of an anticancer agent SN-38 in humans2012
- Author(s)
  Tomoko Sugiura, Ken-ichi Fujita, Hidenori Okumura, Saki Umeda, Noritaka Nakamichi, Yasutsuna Sasaki, Yukio Kato
- Organizer
  27th Japanese Society for the Study of Xenobiotics annual meeting
- Place of Presentation
  Tokyo
- Data Source
  KAKENHI-PROJECT-23590198
[Presentation] Partial inhibition by uremic toxins of hepatic uptake of an active metabolites SN-38 of irinotecan in humans2012
- Author(s)
  Fujita K, Sugiura T, Nakamichi N, Akiyama Y, Sasaki Y, Kato Y
- Organizer
  71^<st> Japan Cancer Association meeting
- Place of Presentation
  Sapporo
- Data Source
  KAKENHI-PROJECT-23590198
[Presentation] Partial inhibition by uremic toxins of hepatic uptake of an active metabolite SN-38 of irinotecan in humans2012
- Author(s)
  Fujita K, Sugiura T, Umeda S, Okumura H, Nakamichi N, Sasaki Y, Kato Y
- Organizer
  33^<rd> Annual meeting of the Japanese Society of Clinical Pharmacology and Therapeutics
- Place of Presentation
  Naha
- Data Source
  KAKENHI-PROJECT-23590198
[Presentation] Partial inhibition by uremic toxins of hepatic uptake of an active metabolites SN-38 of irinotecan in humans2012
- Author(s)
  Ken-ichi Fujita, Tomoko Sugiura, Noritaka Nakamichi, Yuko Akiyama, Yasutsuna Sasaki, Yukio Kato
- Organizer
  71st Japan Cancer Association meeting
- Place of Presentation
  Sapporo
- Data Source
  KAKENHI-PROJECT-23590198
[Presentation] Characterization of hepatic uptake mechanism for SN-38, an active metabolite of the anticancer agent irinotecan in humans2012
- Author(s)
  Fujita K, Sugiura T, Umeda S, Okumura H, Nakamichi N, Sasaki Y, Kato Y
- Organizer
  The 18^<th> International Society for the Study of Xenobiotics North American Regional meeting
- Place of Presentation
  Dallas
- Data Source
  KAKENHI-PROJECT-23590198
[Presentation] Partial inhibition by uremic toxins of hepatic uptake of an active metabolite SN-38 of irinotecan in humans2012
- Author(s)
  Ken-ichi Fujita, Tomoko Sugiura, Saki Umeda, Hidenori Okumura, Noritaka Nakamichi, Yasutsuna Sasaki, Yukio Kato
- Organizer
  33rd Annual meeting of the Japanese Society of Clinical Pharmacology and Therapeutics
- Place of Presentation
  Naha
- Data Source
  KAKENHI-PROJECT-23590198
[Presentation] Characterization of hepatic uptake mechanism for SN-38, an active metabolite of the anticancer agent irinotecan in humans2012
- Author(s)
  Ken-ichi Fujita, Tomoko Sugiura, Saki Umeda, Hidenori Okumura, Noritaka Nakamichi, Yasutsuna Sasaki, Yukio Kato
- Organizer
  The 18th International Society for the Study of Xenobiotics North American Regional meeting
- Place of Presentation
  Dallas, USA
- Data Source
  KAKENHI-PROJECT-23590198
[Presentation] Involvement of OATP and inhibition by uremic toxins in hepatic uptake of an anticancer agent SN-38 in humans2012
- Author(s)
  Sugiura T, Fujita K, Okumura H, Umeda S, Nakamichi N, Sasaki Y, Kato Y
- Organizer
  27^<th> Japanese Society for the Study of Xenobiotics annual meeting
- Place of Presentation
  Tokyo
- Data Source
  KAKENHI-PROJECT-23590198
[Presentation] 転移性結腸・直腸がん一次治療の臨床及び経済的評価2011
- Author(s)
  安島秀友、緒方宏泰、藤田健一、高橋晴美、佐々木康綱
- Organizer
  第2回日本アプライド・セラピューティクス学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23590652
[Presentation] Comparison of clinical outcome and overall costs for first-line FOLFIRI and modified FOLFOX62011
- Author(s)
  Ajima H, Ogata H, Fujita K, Sunakawa Y, Mizono K, Ishida H, Yamashita K, Nakayama H, Kawara K, Takahashi H and Sasaki Y
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-23590652
[Presentation] ssociation of pharmacokinetics or pharmacogenomics with toxicity of erlotinib in patients with advanced NSCLC
- Author(s)
  Takashi Hirose, Ken-ichi Fujita, Sojiro Kusumoto, Takao Shirai, Tomohide Sugiyama, Masanao Nakashima, Tohru Ohmori, Yasutsuna Sasaki, Atsuhisa Tamura , Ken Ohta
- Organizer
  第12回臨床腫瘍学会
- Data Source
  KAKENHI-PROJECT-23590648
[Presentation] 極めて腎機能が低下したがん患者において，SN-38の血漿蛋白結合は低下し遊離形濃度が顕著に上昇する．
- Author(s)
  藤田健一，増尾友祐，奥村英典，砂川優，嶋田顕，河原香織，秋山祐子，佐々木康綱，加藤将夫
- Organizer
  第35回日本臨床薬理学会学術総会
- Place of Presentation
  松山
- Year and Date
  2015-03-05 – 2015-03-07
- Data Source
  KAKENHI-PROJECT-26460205
[Presentation] Change in plasma protein binding of SN-38, an active metabolite of irinotecan, in cancer patients with severe renal failure (SRF).
- Author(s)
  Ken-ichi Fujita, Hidenori Okumura, Yusuke Masuo, Yu Sunakawa, Ken Shimada, Kaori Kawara, Yuko Akiyama, Yasutsuna Sasaki, Yukio Kato
- Organizer
  The 39th European Society for Medical Oncology annual meeting
- Place of Presentation
  Madrid
- Year and Date
  2014-09-27 – 2014-09-30
- Data Source
  KAKENHI-PROJECT-26460205
[Presentation] 非小細胞肺癌に対するエルロチニブの毒性に影響を与える薬物動態、薬理遺伝学的検討
- Author(s)
  廣瀬敬, 藤田健一, 楠本壮二郎, 白井崇生, 村田泰則, 大木康成, 杉山智英, 石田博雄, 中嶌賢尚, 山岡利光, 奥田健太郎, 大西司, 大森亨, 佐々木康綱, 田村厚久, 大田健
- Organizer
  第54回日本呼吸器学会
- Data Source
  KAKENHI-PROJECT-23590648
[Presentation] 尿毒症物質による肝膜輸送体OATP1B1の阻害様式．
- Author(s)
  小木達也，増尾友佑，藤田健一，北村正典，奥村英典，中道範隆，佐々木康綱，国嶋崇隆，加藤将夫
- Organizer
  第36回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  徳島
- Year and Date
  2014-11-20 – 2014-11-21
- Data Source
  KAKENHI-PROJECT-26460205
[Presentation] Optimization of the dose of irinotecan in cancer patients with severe renal failure (SRF) based on physiologically-based pharmacokinetic (PBPK) model.
- Author(s)
  Ken-ichi Fujita, Yusuke Masuo, Hidenori Okumura, Yasutsuna Sasaki and Yukio Kato
- Organizer
  116th American Society for Clinical Pharmacology and Therapeutics annual meeting
- Place of Presentation
  New Orlearns
- Year and Date
  2015-03-05 – 2015-03-07
- Data Source
  KAKENHI-PROJECT-26460205

1. FUJITA Ken-ichi (60281820)

# of Collaborated Projects: 6 results

# of Collaborated Products: 37 results
2. OKAZAKI Yasushi (80280733)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
3. KATO Yukio (30251440)

# of Collaborated Projects: 2 results

# of Collaborated Products: 26 results
4. Yamaoka Toshimitsu (40384359)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
5. ANDO Yuichi (10360083)

# of Collaborated Projects: 2 results

# of Collaborated Products: 15 results
6. 大森亨 (10276529)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
7. OGATA Hiroyasu (70133626)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. NAGASHIMA Fumio (70348209)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
9. HIROSE Takashi (40307038)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
10. TAKAHASHI Harumi (20211344)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
11. SHIOMI Mari (30300768)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. NANJHO Shuji (70328615)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. OYAMA Hiroshi (30194640)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
14. ONOGI Yuzo (90233593)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. KOIDE Daisuke (50313143)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 足立満 (10095870)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 荒田悟 (20159502)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
18. 本間まゆみ (20527171)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 楠本壮二郎 (30465091)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
20. 中嶌賢尚 (90365768)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. LEE T.M. Michael

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. CAVALLARI Larisa H

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 大場基

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Sasaki Yasutsuna 佐々木 康綱

SASAKI Yasutsuna 佐々木 康綱

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[Book] 抗悪性腫瘍薬.医系薬理学 改訂2版(遠藤仁,橋本敬太郎,後藤勝年,金井好克編)2005

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[Journal Article] Distinct Afatinib Resistance Mechanisms Identified in Lung Adenocarcinoma Harboring an EGFR Mutation.2017

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[Journal Article] The acquired resistant mechanisms for sequential treatment of EGFR-TKI to Met-TKI/EGFR-TKI in a Met amplified EGFR-TKI resistant lung adenocarcinoma cells, harboring EGFR activating mutation.2016

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[Journal Article] Increased plasma concentrations of unbound SN-38, the active metabolite of irinotecan, in cancer patients with severe renal failure2016

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[Journal Article] Optimization of cancer chemotherapy on the basis of pharmacokinetics and pharmacodynamics : from patients enrolled in clinical trials to those in the 'real world'2014

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[Journal Article] Optimization of cancer chemotherapy on the basis of pharmacokinetics and pharmacodynamics: from patients enrolled in ‘clinical trials’ to those in the ‘real world’2014

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[Journal Article] Direct inhibition and down-regulation by uremic plasma components of hepatic uptake transporter for SN-38, an active metabolite of irinotecan, in humans2014

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Sasaki Yasutsuna 佐々木康綱

SASAKI Yasutsuna 佐々木康綱

[Book] 抗悪性腫瘍薬.医系薬理学改訂2版(遠藤仁,橋本敬太郎,後藤勝年,金井好克編)2005

[Journal Article] UGT1A11/28 and 1/6 genotypes have no effects on the efficacy and toxicity of FOLFIRI in Japanese patients with advanced colorectal cancer.2010

[Journal Article] Genetic testing for UGT1A128 and 6 in Japanese patients who receive irinotecan chemotherapy.2008