Takahashi Shinichi 高橋慎一

… Alternative Names

TAKAHASHI Shinichi 高橋慎一

高橋慎一タカハシシンイチ

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Researcher Number	20236285
Other IDs
Affiliation (Current)	2025: 埼玉医科大学, 医学部, 教授 2025: 慶應義塾大学, 殿町先端研究教育連携スクエア, 特任教授
Affiliation (based on the past Project Information) *help	2019 – 2023: 慶應義塾大学, 医学部(信濃町), 特任教授 2016 – 2018: 慶應義塾大学, 医学部(信濃町), 准教授 2012 – 2015: 慶應義塾大学, 医学部, 准教授 2007 – 2008: 慶應義塾大学, 医学部, 准教授 2005 – 2006: 慶應義塾大学, 医学部, 助教授
Review Section/Research Field	Principal Investigator Basic Section 52020:Neurology-related / Neurology Except Principal Investigator Neurology
Keywords	Principal Investigator アストログリア / アストロサイト / ミクログリア / ヒトiPSC / 脊髄運動ニューロン / ヒトiPS細胞 / ケトン体 / ペントースリン酸経路 / ロピニロール / 筋萎縮性側索硬化症 … More / トランスクリプトーム / プロテオーム解析 / 体液由来細胞外小胞 / ロピニロール塩酸塩 / グリア細胞 / 14Cグルコース / 代謝コンパートメント / 脳梗塞 / ニューロン / 脳虚血 / ＴＬＲ４ / 一酸化窒素 / 髄鞘イメージング / オリゴデンドロサイト / フマル酸ジメチル / 脳虚血モデル / βヒドロキシ酪酸 / glycolysis / ER stress / TLR4 / LPS / PPP / Keap1/Nrf2 / astroglia / 酸化ストレス / 高血糖 / 認知症 / 糖尿病 … More Except Principal Investigator dimethyl fumarate / Nrf2 / 脳虚血 / 脳神経疾患 / Keap1/Nrf2 / 脳梗塞 / stroke / MCA occlusion / cerebral ischemia / dimethylfumarate / DMF / 脳毛細血管 / 脳血流 / 皮質拡延性抑制 / 片頭痛前兆 / 大脳皮質拡延性抑制 / 脳微小循環 / 片頭痛 Less

ALS運動ニューロン標的iPS細胞創薬から同定された薬物のグリア細胞疾患修飾作用Principal Investigator
- Principal Investigator
  
  高橋慎一
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Keio University
A novel treatment of cerebral infarction with neuroprotective astrocytes induced by inflammatory microgliaPrincipal Investigator
- Principal Investigator
  
  TAKAHASHI Shinichi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Keio University
Drug repositioning for treatment in cerebral ischemia
- Principal Investigator
  
  Abe Takato
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Osaka City University
Novel thherapeutic strategy against ischemic stroke based on glial cell interaction by ketone bodiesPrincipal Investigator
- Principal Investigator
  
  TAKAHASHI Shinichi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Keio University
The new therapy for cerebral infarction by modulating Keap1/Neaf2 system
- Principal Investigator
  
  Abe Takato
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Osaka City University
  Keio University
Astrocytic neuroprotective mechanism against diabetic encephalopathy through metabolic stress responsePrincipal Investigator
- Principal Investigator
  
  TAKAHASHI Shinichi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Keio University
Studies on cortical spreading depression and changes in brain capillary blood flow in acute phase of brain ischemia or aura in acute migraine
- Principal Investigator
  
  SUZUKI Norihiro
- Project Period (FY)
  2005 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurology
- Research Institution
  Keio University

All 2023 2022 2021 2020 2019 2017 2016 2015 2014 2013 2012 2007 2006 Other

All Journal Article Presentation Book

[Book] Psychology and paho-physiological outcomes of eating2021
- Author(s)
  Shinichi Takahashi
- Publisher
  IntechOpen
- Data Source
  KAKENHI-PROJECT-19K08002
[Book] 脳血管の解剖;動脈系、静脈系(井林雪郎編)(ファーマナビゲーター脳卒中編)2006
- Author(s)
  高橋一司, 鈴木則宏
- Publisher
  メディカルビュー社(東京)
- Data Source
  KAKENHI-PROJECT-17390255
[Journal Article] Induced pluripotent stem cells‐based disease modeling, drug screening, clinical trials, and reverse translational research for amyotrophic lateral sclerosis2023
- Author(s)
  Okano Hideyuki、Morimoto Satoru、Kato Chris、Nakahara Jin、Takahashi Shinichi
- Journal Title
  
  Journal of Neurochemistry
  
  Volume: 167 Issue: 5 Pages: 603-614
- DOI
  10.1111/jnc.16005
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15736, KAKENHI-PROJECT-22K07500, KAKENHI-PLANNED-21H05278, KAKENHI-PROJECT-20H00485
[Journal Article] Phase 1/2a clinical trial in ALS with ropinirole, a drug candidate identified by iPSC drug discovery2023
- Author(s)
  Morimoto Satoru、Takahashi Shinichi、Ito Daisuke et al.
- Journal Title
  
  Cell Stem Cell
  
  Volume: 30 Issue: 6 Pages: 766-780.e9
- DOI
  10.1016/j.stem.2023.04.017
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15736, KAKENHI-PROJECT-22K07500, KAKENHI-PROJECT-21K06845, KAKENHI-PROJECT-21K07411, KAKENHI-PLANNED-21H05278, KAKENHI-PROJECT-20H00485, KAKENHI-PROJECT-23K21397
[Journal Article] Metabolic Contribution and Cerebral Blood Flow Regulation by Astrocytes in the Neurovascular Unit2022
- Author(s)
  Takahashi Shinichi
- Journal Title
  
  Cells
  
  Volume: 11 Issue: 5 Pages: 813-813
- DOI
  10.3390/cells11050813
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08002, KAKENHI-PROJECT-22K07500
[Journal Article] Maiden voyage: induced pluripotent stem cell-based drug screening for amyotrophic lateral sclerosis2022
- Author(s)
  Ito Daisuke、Morimoto Satoru、Takahashi Shinichi、Okada Kensuke、Nakahara Jin、Okano Hideyuki
- Journal Title
  
  Brain
  
  Volume: 146 Issue: 1 Pages: 13-19
- DOI
  10.1093/brain/awac306
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07500, KAKENHI-PROJECT-23K21397
[Journal Article] Neuroprotection and Disease Modification by Astrocytes and Microglia in Parkinson Disease2022
- Author(s)
  Takahashi Shinichi、Mashima Kyoko
- Journal Title
  
  Antioxidants
  
  Volume: 11 Issue: 1 Pages: 170-170
- DOI
  10.3390/antiox11010170
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08002, KAKENHI-PROJECT-20K16502, KAKENHI-PROJECT-22K07500
[Journal Article] Lactate and Ketone Bodies Act as Energy Substrates as Well as Signal Molecules in the Brain2021
- Author(s)
  Takahashi Shinichi
- Journal Title
  
  Psychology and paho-physiological outcomes of eating
  
  Volume: -
- DOI
  10.5772/intechopen.97035
- ISBN
  9781839687761, 9781839687778
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08002
[Journal Article] Ropinirole hydrochloride for amyotrophic lateral sclerosis: A single-center, randomized feasibility, double-blind, placebo-controlled trial2021
- Author(s)
  Morimoto Satoru、Takahashi Shinichi、Ito Daisuke、Date Yugaku、Okada Kensuke、Chyi Chai Muh、Nishiyama Ayumi、Suzuki Naoki、Fujimori Koki、Takao Masaki、Hirai Miwa、Kabe Yasuaki、Suematsu Makoto、Jinzaki Masahiro、Aoki Masashi、Fujiki Yuto、Sato Yasunori、Suzuki Norihiro、Nakahara Jin、Okano Hideyuki
- Journal Title
  
  medRxiv
  
  Volume: 2021(Dec)
- DOI
  10.1101/2021.12.05.21267266
- Open Access
- Data Source
  KAKENHI-PROJECT-19K08002
[Journal Article] Neuroprotective Function of High Glycolytic Activity in Astrocytes: Common Roles in Stroke and Neurodegenerative Diseases2021
- Author(s)
  Takahashi Shinichi
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 22 Issue: 12 Pages: 6568-6568
- DOI
  10.3390/ijms22126568
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08002
[Journal Article] Human Astrocytes Model Derived from Induced Pluripotent Stem Cells2020
- Author(s)
  Leventoux Nicolas、Morimoto Satoru、Imaizumi Kent、Sato Yuta、Takahashi Shinichi、Mashima Kyoko、Ishikawa Mitsuru、Sonn Iki、Kondo Takahiro、Watanabe Hirotaka、Okano Hideyuki
- Journal Title
  
  Cells
  
  Volume: 9 Issue: 12 Pages: 2680-2680
- DOI
  10.3390/cells9122680
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08002, KAKENHI-PROJECT-20K16502, KAKENHI-PROJECT-19K16927
[Journal Article] Metabolic compartmentalization between astroglia and neurons in physiological and pathophysiological conditions of neurovascular unit. Neuropathology.2020
- Author(s)
  Shinichi Takahashi
- Journal Title
  
  Neuropathology
  
  Volume: 40 Issue: 2 Pages: 121-137
- DOI
  10.1111/neup.12639
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08002
[Journal Article] 特集神経疾患のドラッグ･リポジショニング-新時代へ ALS治療薬候補としてのロピニロール塩酸塩2019
- Author(s)
  Shinichi Takahashi, Satoru Morimoto, Hideyuki Okanao
- Journal Title
  
  BRAIN and NERVE
  
  Volume: 71 Issue: 9 Pages: 943-952
- DOI
  10.11477/mf.1416201386
- ISSN
  1344-8129, 1881-6096
- Year and Date
  2019-09-01
- Data Source
  KAKENHI-PROJECT-19K08002
[Journal Article] Ropinirole, a new ALS drug candidate developed using iPSCs.2019
- Author(s)
  Hideyuki Okano, Daisuke Yasuda, Koki Fujimori, Satoru Morimoto, Shinichi Takahashi
- Journal Title
  
  Trends Pharmacol Sci
  
  Volume: 41(2) Issue: 2 Pages: 99-109
- DOI
  10.1016/j.tips.2019.12.002
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08002
[Journal Article] 増大特集 ALS2019 ロピニロール塩酸塩-iPS細胞創薬2019
- Author(s)
  Shinichi Takahashi, Satoru Morimoto, Komei Fukushima, Jin Nakahara, Hideyuki Okano
- Journal Title
  
  BRAIN and NERVE
  
  Volume: 71 Issue: 11 Pages: 1279-1288
- DOI
  10.11477/mf.1416201438
- ISSN
  1344-8129, 1881-6096
- Year and Date
  2019-11-01
- Data Source
  KAKENHI-PROJECT-19K08002
[Journal Article] Ropinirole hydrochloride remedy for amyotrophic lateral sclerosis - Protocol for a randomized, double-blind, placebo-controlled, single-center, and open-label continuation phase I/IIa clinical trial (ROPALS trial) -.2019
- Author(s)
  .Satoru Morimoto, Shinichi Takahashi, Komei Fukushima, Hideyuki Saya, Norihiro Suzuki, Masashi Aoki, Hideyuki Okano, Jin Nakahara
- Journal Title
  
  Regen Ther
  
  Volume: 11 Pages: 143-166
- DOI
  10.1016/j.reth.2019.07.002
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08002
[Journal Article] くも膜下出血後のNVU機能障害と脳循環代謝調節異常．2017
- Author(s)
  高橋愼一
- Journal Title
  
  脳血管攣縮
  
  Volume: 33 Pages: 3-7
- Data Source
  KAKENHI-PROJECT-15K09324
[Journal Article] q-Space Myelin Map imaging for longitudinal analysis of demyelination and remyelination in multiple sclerosis patients treated with fingolimod: A preliminary study2017
- Author(s)
  Mariko Tanikawa, Jin Nakahara, Junichi Hata, Shigeaki Suzuki, Kanehiro Fujiyoshi, Hirokazu Fujiwara, Suketaka Momoshima, Masahiro Jinzaki, Masaya Nakamura, Hideyuki Okano, Shinichi Takahashi, Norihiro Suzuki
- Journal Title
  
  J Neurol Sci
  
  Volume: 15 Pages: 352-357
- DOI
  10.1016/j.jns.2017.01.009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26860982, KAKENHI-PROJECT-15K09324
[Journal Article] Application of q-Space Diffusion MRI for the Visualization of White Matter2016
- Author(s)
  Fujiyoshi K, Hikishima K, Nakahara J, Tsuji O, Hata J, Konomi T, Nagai T, Shibata S, Kaneko S, Iwanami A, Momoshima S, Takahashi S, Jinzaki M, Suzuki N, Toyama Y, Nakamura M, Okano H.
- Journal Title
  
  Journal of Neuroscience
  
  Volume: 36(9) Issue: 9 Pages: 2796-2808
- DOI
  10.1523/jneurosci.1770-15.2016
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462714, KAKENHI-PROJECT-26860982, KAKENHI-PLANNED-26112003, KAKENHI-PROJECT-25670424, KAKENHI-PROJECT-25713035, KAKENHI-PROJECT-15K09324
[Journal Article] A possible role of microglia-derived nitric oxide by lipopolysaccharide in activation of astroglial pentose-phosphate pathway via the Keap1/Nrf2 system2016
- Author(s)
  Takuya Iizumi, Shinichi Takahashi, Kyoko Mashima, Kazushi Minami, Yoshikane Izawa, Takato Abe, Takako Hishiki, Makoto Suematsu, Mayumi Kajimura, Norihiro Suzuki
- Journal Title
  
  Journal of Neuroinflammation
  
  Volume: 13 Issue: 1 Pages: 99-99
- DOI
  10.1186/s12974-016-0564-0
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19522, KAKENHI-PROJECT-15K09324, KAKENHI-PROJECT-16K07066
[Journal Article] アストログリアをターゲットとした脳梗塞治療戦略の構築.2015
- Author(s)
  高橋愼一
- Journal Title
  
  脳循環代謝
  
  Volume: 26 Pages: 67-75
- NAID
  130005093694
- Open Access
- Data Source
  KAKENHI-PROJECT-15K09324
[Journal Article] 神経細胞およびグリア細胞におけるケトン体代謝の重要性2015
- Author(s)
  高橋愼一
- Journal Title
  
  Annual Review神経2015
  
  Volume: 6 Pages: 196-203
- Open Access
- Data Source
  KAKENHI-PROJECT-15K09324
[Journal Article] Subsequent vascular events after ischemic stroke: the Japan Statin Treatment Against Recurrent Stroke-Longitudinal.2014
- Author(s)
  Nomura E, Suzuki A, Inoue I, Nakagawara L, Takahashi K, Takahashi T, Manabe Y, Yokota C, Okada K, Nishihara T, Yamamoto Y, Noda K, Takahashi S, Ibayashi S, Takagi M, Kitagawa K, Tanahashi N, Kuriyama M, Hirata K, Hosomi N, Minematsu K, Kobayashi K, Matsumoto M.
- Journal Title
  
  J Stroke Cerebrovasc Dis
  
  Volume: 24(2) Issue: 2 Pages: 473-9
- DOI
  10.1016/j.jstrokecerebrovasdis.2014.09.023
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591276
[Journal Article] Cellular origin and regulation of D- and L-serine in vitro and in vivo models of cerebral ischemia.2014
- Author(s)
  Abe T, Suzuki M, Sasabe J, Takahashi S, Unekawa M, Mashima K, Iizumi T, Hamase K, Konno R, Aiso S, Suzuki N.
- Journal Title
  
  J Cereb Blood Flow Metab
  
  Volume: 34(12) Issue: 12 Pages: 1928-1935
- DOI
  10.1038/jcbfm.2014.164
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24591276, KAKENHI-PROJECT-26350981, KAKENHI-PROJECT-26461279
[Journal Article] Roles and regulation of ketogenesis in cultured astroglia and neurons under hypoxia and hypoglycemia.2014
- Author(s)
  Takahashi S, Iizumi T, Mashima K, Abe T, Suzuki, N.
- Journal Title
  
  ASN Neuro
  
  Volume: 6(5) Issue: 5 Pages: 1-1
- DOI
  10.1177/1759091414550997
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24591276
[Journal Article] Roles of metabolic compartmentalization by astrocytes and neurons in the pathophysiology and treatment of Parkinson’s disease2013
- Author(s)
  Shinichi Takahashi, Morinobu Seki, Norihiro Suzuki
- Journal Title
  
  Brain and Nerve
  
  Volume: 65(2) Pages: 1497-1508
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591276
[Journal Article] Astroglial pentose phosphate pathway rates in response to high-glucose environments.2012
- Author(s)
  Shinichi Takahashi, Yoshikane Izawa, Norihiro Suzuki
- Journal Title
  
  ASN NEURO
  
  Volume: 4(2) Issue: 2
- DOI
  10.1042/an20120002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591276
[Journal Article] Effects of fluctuating glucose concentrations on oxidative metabolism of glucose in cultured neurons and astroglia.2012
- Author(s)
  Shinichi Takahashi, Yoshikane Izawa, Norihiro Suzuki
- Journal Title
  
  Journal of Diabetes Mellitus
  
  Volume: 2(1) Issue: 01 Pages: 19-26
- DOI
  10.4236/jdm.2012.21004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591276
[Journal Article] Astrogliopathy as a loss of astroglial protective function against glycoxidative stress under hyperglycemia2012
- Author(s)
  Shinichi Takahashi, Yoshikane Izawa, Norihiro Suzuki
- Journal Title
  
  Rinsho Shinkeigaku
  
  Volume: 52 Issue: 1 Pages: 41-51
- DOI
  10.5692/clinicalneurol.52.41
- NAID
  130004505025
- ISSN
  0009-918X, 1882-0654
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591276
[Journal Article] Novel mutation of the Notch3 gene in a Japanese patient with CADASIL.2007
- Author(s)
  Oki K, Nagata E, Ishiko A, Tanaka K, Takahashi K, Tabira T, Katayama T, Suzuki N
- Journal Title
  
  Eur J Neurol 14
  
  Pages: 464-466
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390255
[Journal Article] Metabolic properties of astrocytes differentiated from rat neurospheres.2006
- Author(s)
  Abe T, Takahashi S, Suzuki N
- Journal Title
  
  Brain Research 1101
  
  Pages: 5-11
- Data Source
  KAKENHI-PROJECT-17390255
[Journal Article] Oxidative metabolism in cultured rat astroglia : effects of reducing the glucose concentration in the culture medium and of D-aspartate or potassium stimulation2006
- Author(s)
  Abe T, Takahashi S, Suzuki N
- Journal Title
  
  J Cereb Blood Flow Metab 26
  
  Pages: 153-160
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390255
[Presentation] Neurovascular unit and stroke (Symposium 34: Novel Treatment Targets for Brain Disorders)2023
- Author(s)
  Shinichi Takahashi
- Organizer
  The 12th World Congress of Microcirculation
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07500
[Presentation] Neurovascular unit and glial cells: glutamate and dopamine2023
- Author(s)
  Shinichi Takahashi
- Organizer
  Neurovascular Unit Conference 2023: US-Japan Joint Workshop on the Neurovascular Unit
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07500
[Presentation] Ropinirole hydrochloride suppresses cholesterol synthetic pathway in ALS spinal motor neurons2023
- Author(s)
  Shinichi Takahashi, Satoru Morimoto, Chris Kato, Shiho Nakamura, Fumiko Ozawa, Daisuke Ito, Yugaku Date, Kensuke Okada, Jin Nakahara, Hideyuki Okano
- Organizer
  Society for Neuroscience 2023 Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07500
[Presentation] A Practical Induction And Evaluation Method Of Human Spinal Motor Neurons To Accelerate Drug Screening For ALS2022
- Author(s)
  Selena Setsu, Satoru Morimoto, Shiho Nakamura, Fumiko Ozawa, Shinichi Takahashi, Hideyuki Okano
- Organizer
  ISSCR 2022 Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07500
[Presentation] Results Of A Randomized Clinical Trial of Ropinirole Hydrochloride For ALS (ROPALS) Based On iPS Cell Drug Discovery.2021
- Author(s)
  Shinichi Takahashi, Satoru Morimoto, Daisuke Ito, Yugaku Date, Kensuke Okada, Chai Muh Chyi, Ayumi Nishiyama, Naoki Suzuki, Miwa Hirai, Yasuaki Kabe, Makoto Suematsu, Masahiro Jinzaki, Masashi Aoki, Yasunori Sato, Jin Nakahara, Norihiro Suzuki, Hideyuki Okano
- Organizer
  第62回日本神経学会学術大会、Late Breakingセッション
- Data Source
  KAKENHI-PROJECT-19K08002
[Presentation] ROPALS trial: phase 1/2a, double-blind, placebo-controlled study of ropinirole hydrochloride for ALS patients based on the iPSC drug repositioning.2021
- Author(s)
  Shinichi Takahashi, Satoru Morimoto, Kensuke Okada, Yugaku Date, Daisuke Ito, Jin Nakahara, Hideyuki Okano
- Organizer
  International Society for Stem Cell Research　(ISSCR) Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08002
[Presentation] ROPALS trial: phase 1/2a, double-blind, placebo-controlled study of ropinirole hydrochloride for ALS patients based on the iPSC drug repositioning.2021
- Author(s)
  Satoru Morimoto, Shinichi Takahashi, Kensuke Okada, Yugaku Date, Daisuke Ito, Jin Nakahara, Hideyuki Okano
- Organizer
  The 44th Annual Meeting of the Japanese Neuroscience Society
- Data Source
  KAKENHI-PROJECT-19K08002
[Presentation] Phase 1/2a, Double-blind, Placebo-controlled Study of Ropinirole Hydrochloride (ROPALS trial) based on the iPSC drug repositioning.2021
- Author(s)
  Shinichi Takahashi, Satoru Morimoto, Kensuke Okada, Yugaku Date, Daisuke Ito, Jin Nakahara, Hideyuki Okano
- Organizer
  American Academy of Neurology 73rd Annual Meeting
- Data Source
  KAKENHI-PROJECT-19K08002
[Presentation] Phase 1/2a, Double-blind, Placebo-controlled Study of Ropinirole Hydrochloride (ROPALS).2021
- Author(s)
  Shinichi Takahashi, Satoru Morimoto, Kensuke Okada, Yugaku Date, Daisuke Ito, Jin Nakahara, Hideyuki Okano
- Organizer
  第62回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-19K08002
[Presentation] Ropinirole hydrochloride identified by iPSC drug discovery for amyotrophic lateral sclerosis: a randomised, double-blind , placebo-controlled phase 1/2Atrial.2021
- Author(s)
  Satoru Morimoto, Shinichi Takahashi, Daisuke Ito, Yugaku Date, Kensuke Okada, Muh Chyi Chai, Ayumi Nishiyama, Naoki Suzuki, Miwa Hirai, Yasuaki Kabe, Makoto Suematsu, Masahiro Jinzaki, Masashi Aoki, Yasunori Sato, Jin Nakahara, Norihiro Suzuki, Hideyuki Okano
- Organizer
  ISSCR in Tokyo
- Data Source
  KAKENHI-PROJECT-19K08002
[Presentation] ROPALS trial based on the iPSC drug repositioning for ALS: baseline profiles of trial participants.2020
- Author(s)
  Shinichi Takahashi, Satoru Morimoto, Kensuke Okada, Yugaku Daté, Daisuke Ito, Jin Nakahara, Hideyuki Okano
- Organizer
  第61回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-19K08002
[Presentation] がん関連脳卒中の疾患概念．シンポジウム３「がん関連脳卒中」2020
- Author(s)
  高橋愼一
- Organizer
  第23回日本栓子検出と治療学会
- Data Source
  KAKENHI-PROJECT-19K08002
[Presentation] ROPALS trial based on the iPSC drug repositioning for ALS: baseline profiles of trial participants.2020
- Author(s)
  高橋愼一，森本悟, 岡田健佑，伊達悠岳，伊東大介，中原仁，岡野栄之
- Organizer
  第63回日本脳循環代謝学会学術集会
- Data Source
  KAKENHI-PROJECT-19K08002
[Presentation] Ropinirole Hydrochloride Remedy for Amyotrophic Lateral Sclerosis2019
- Author(s)
  Shinichi Takahashi, Satoru Morimoto, Hideyuki Saya, Hideyuki Okano, Masashi Aoki, Norihiro Suzuki, Jin Nakahara
- Organizer
  AAN 2019 - American Academy of Neurology 71st Annual Meeting
- Data Source
  KAKENHI-PROJECT-19K08002
[Presentation] Study protocol for a phase Ⅰ/Ⅱa, double-blind, placebo-controlled trial of ropinirole for ALS2019
- Author(s)
  Shinichi Takahashi， Satoru Morimoto， Hideyuki Saya， Hideyuki Okano， Masashi Aoki， Norihiro
- Organizer
  第60回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-19K08002
[Presentation] Keap1/Nrf2 System-dependent Astroglial Neuroprotection Against Dopamine2019
- Author(s)
  Shinichi Takahashi, Kyoko Mahima, Kazushi Minami, Yoshikane Izawa, Takato Abe, Naoki Tsukada, Takako Hishiki, Mayumi Kajimura, Norihiro Suzuki
- Organizer
  BRAIN & BRAIN PET 2019
- Data Source
  KAKENHI-PROJECT-19K08002
[Presentation] Phase 1/2a, Double-blind, Placebo-controlled Study with an Open-label Extension of Ropinirole Hydrochloride Extended-Release Tablets (ROPALS trial based on the iPSC drug repositioning)2019
- Author(s)
  Shinichi Takahashi, Satoru Morimoto, Kensuke Okada, Yugaku Daté, Daisuke Ito, Jin Nakahara, Hideyuki Okano
- Organizer
  30th International Symposium on ALS/MND
- Data Source
  KAKENHI-PROJECT-19K08002
[Presentation] Activated microglia enhance astroglial neuroprotective pentose-phosphate pathway through the activation of the Keap1/Nrf2 system by nitric oxide.2017
- Author(s)
  Shinichi Takahashi, Takuya Iizumi, Kyoko Mashima, Kazushi Minami, Yoshikane Izawa, Takato Abe, Takako Hishiki, Makoto Suematsu, Mayumi Kajimura, Norihiro Suzuki
- Organizer
  XXIII World Congress of Neurology (WCN2017) Sept 16-21, 2017, Kyoto, Japan
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09324
[Presentation] 脳血管障害の最近の動向．2017
- Author(s)
  高橋愼一
- Organizer
  日本神経学会　生涯教育講演会（平成29年5月14日、東京医科歯科大学鈴木章夫記念講堂、東京都文京区）
- Invited
- Data Source
  KAKENHI-PROJECT-15K09324
[Presentation] Cytoprotective role of microglia-derived nitric oxide induced by TLR4 stimulation in concert with astroglial pentose-phosphate pathway activation through the Keap1/Nrf2 system.2017
- Author(s)
  Shinichi Takahashi, Takuya Iizumi, Kyoko Mashima, Kazushi Minami, Yoshikane Izawa, Takato Abe, Takako Hishiki, Makoto Suematsu, Mayumi Kajimura, Norihiro Suzuki
- Organizer
  BRAIN & BRAIN PET 2017(28th Symposium on Cerebral Blood Flow, Metabolism and Function/13th Conference on Quantification of Brain Function with PET) April 1-4, 2017, Berlin, Germany
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09324
[Presentation] Neuroprotective effects of dimethyl fumarate on cerebral ischemia-reperfusion injury in mice2017
- Author(s)
  Kazushi Minami, Takato Abe, Naoki Tsukada, Miyuki Unekawa, Shinichi Takahashi, Norihiro Suzuki
- Organizer
  The 8th Korea-Japan Joint Stroke Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09762
[Presentation] 脳血管障害基礎研究の勧め．2017
- Author(s)
  高橋愼一
- Organizer
  第42回日本脳卒中学会総会（STROKE 2017）（平成29年3月26-28日、大阪府立国際会議場、大阪府大阪市）
- Invited
- Data Source
  KAKENHI-PROJECT-15K09324
[Presentation] Neurovascular unitと脳循環代謝：Update．2017
- Author(s)
  高橋愼一
- Organizer
  第35回日本神経治療学会　教育講演（平成29年11月15－17日、ソニックシティー大宮、埼玉県さいたま市）
- Invited
- Data Source
  KAKENHI-PROJECT-15K09324
[Presentation] ラット培養アストログリアとミクログリアのNOを介する酸化ストレス相互応答．2017
- Author(s)
  高橋愼一、飯泉琢矢、伊澤良兼、安部貴人、鈴木則宏
- Organizer
  日本神経治療学会　（平成29年11月15－17日、ソニックシティー大宮、埼玉県さいたま市）
- Data Source
  KAKENHI-PROJECT-15K09324
[Presentation] Cytoprotective role of microglia-derived nitric oxide induced by TLR4 stimulation in concert with astroglial pentose-phosphate pathway activation through the Keap1/Nrf2 system2017
- Author(s)
  S. Takahashi, T. Iizumi, K. Mashima, K. Minami, Y. Izawa, T. Abe, T. Hishiki, M. Suematsu, M. Kajimura and N. Suzuki
- Organizer
  Brain 2017
- Place of Presentation
  ベルリン（ドイツ）
- Year and Date
  2017-04-01
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461279
[Presentation] ラット培養アストログリアにおけるミクログリア依存性、非依存性の酸化ストレス応答.2016
- Author(s)
  飯泉琢矢、高橋愼一、馬島恭子、伊澤良兼、安部貴人、鈴木則宏
- Organizer
  第41回日本脳卒中学会総会（STROKE 2016）
- Place of Presentation
  ロイトン札幌（北海道、札幌市）
- Year and Date
  2016-04-14
- Data Source
  KAKENHI-PROJECT-15K09324
[Presentation] Microglia-derived NO activates astroglial pentose-phosphate pathway through the Keap1/Nrf2 system.2016
- Author(s)
  Takuya Iizumi, Shinichi Takahashi, Kyoko Mashima, Yoshikane Izawa, Takato Abe, Norihiro Suzuki
- Organizer
  第57回日本神経学会学術大会
- Place of Presentation
  神戸国際会議場（兵庫県、神戸市）
- Year and Date
  2016-05-18
- Data Source
  KAKENHI-PROJECT-15K09324
[Presentation] Astroglia exert a neuro-protective role in Parkinson’s disease by reducing oxygen stress through dopamine-induced activation of the pentose-phosphate pathway.2016
- Author(s)
  Kyoko Mashima, Shinichi Takahashi, Takuya Iizumi, Takato Abe, Norihiro Suzuki
- Organizer
  20th International Congress of Parkinson's disease and Movement Disorders
- Place of Presentation
  Messe Berlin（Berlin, Germany）
- Year and Date
  2016-06-19
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09324
[Presentation] アストログリアをターゲットとした脳梗塞治療戦略の構築.2015
- Author(s)
  高橋愼一
- Organizer
  第27回日本脳循環代謝学会総会
- Place of Presentation
  富山国際会議場（富山県、富山市）
- Year and Date
  2015-10-29
- Invited
- Data Source
  KAKENHI-PROJECT-15K09324
[Presentation] 脳小血管病（SVD）スペクトラムにおける白質病変の意義とその対応.2015
- Author(s)
  高橋愼一
- Organizer
  第24回日本脳ドック学会総会
- Place of Presentation
  パシフィコ横浜（神奈川県、横浜市）
- Year and Date
  2015-06-06
- Invited
- Data Source
  KAKENHI-PROJECT-15K09324
[Presentation] Metabolic balance of neuron, glia and vessel.2015
- Author(s)
  Shinichi Takahashi
- Organizer
  The XXVIIth International Symposium on Cerebral Blood Flow, Metabolism and Function & XIIth International Conference on Quantification of Brain Function with PET
- Place of Presentation
  バンクーバー（カナダ）
- Year and Date
  2015-06-27
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09324
[Presentation] アストロサイト研究の現状と展望2013
- Author(s)
  高橋愼一
- Organizer
  第25回日本脳循環代謝学会総会
- Place of Presentation
  札幌
- Invited
- Data Source
  KAKENHI-PROJECT-24591276
[Presentation] 脳梗塞急性期治療：Tissue clock と Reperfusion.2012
- Author(s)
  高橋慎一
- Organizer
  日本麻酔科学会第59回学術集会
- Place of Presentation
  神戸
- Invited
- Data Source
  KAKENHI-PROJECT-24591276
[Presentation] アストロサイトとニューロンの代謝からみたパーキンソン病の病態.2012
- Author(s)
  高橋慎一
- Organizer
  第６回　パーキンソン病・運動障害コングレス
- Place of Presentation
  京都
- Invited
- Data Source
  KAKENHI-PROJECT-24591276
[Presentation] MECHANISM REGULATING D-SERINE AND L-SERINE DURING TRANSIENT MIDDLE CEREBRAL ARTERY OCCLUSION IN A MOUSE MODEL
- Author(s)
  T. Abe, J. Sasabe, M. Suzuki, S. Takahashi, M. Unekawa, T. Iizumi, S. Aiso, N. Suzuki.
- Organizer
  World Stroke Congress 2014
- Place of Presentation
  トルコ・イスタンブール・Halic Congress Centeｒ
- Year and Date
  2014-10-22 – 2014-10-25
- Data Source
  KAKENHI-PROJECT-26461279
[Presentation] CBF/Neurovascular Unit; metabolic balance of neuron.
- Author(s)
  Takahashi S.
- Organizer
  The XXVIIth International Symposium on Cerebral Blood Flow, Metabolism and Function & XIIth International Conference on Quantification of Brain Function with PET
- Place of Presentation
  Vancouver, Canada
- Year and Date
  2015-06-27 – 2015-06-30
- Invited
- Data Source
  KAKENHI-PROJECT-24591276

1. ABE Takato (30365233)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
2. ITOH Yoshiaki (90265786)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. OSADA Takashi (30348635)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. IZAWA Yoshikane (90468471)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
5. 森本悟 (00816952)

# of Collaborated Projects: 2 results

# of Collaborated Products: 20 results
6. 馬島恭子 (30812440)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. 岡野栄之 (60160694)

# of Collaborated Projects: 2 results

# of Collaborated Products: 18 results
8. SUZUKI Norihiro (10158975)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
9. ITO Daisuke (80286450)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. TOMITA Yutaka (60276251)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 畝川美悠紀 (10548481)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
12. 中原仁 (60537950)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 渡部博貴 (30422413)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. FUJIYOSHI Kanehiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 阿部貴人

# of Collaborated Projects: 0 results

# of Collaborated Products: 12 results
16. 芝田晋介

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 畑純一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Takahashi Shinichi 高橋 慎一

TAKAHASHI Shinichi 高橋 慎一

高橋 慎一 タカハシ シンイチ

Research Projects

Research Products

Co-Researchers

ALS運動ニューロン標的iPS細胞創薬から同定された薬物のグリア細胞疾患修飾作用Principal Investigator

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A novel treatment of cerebral infarction with neuroprotective astrocytes induced by inflammatory microgliaPrincipal Investigator

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Drug repositioning for treatment in cerebral ischemia

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Novel thherapeutic strategy against ischemic stroke based on glial cell interaction by ketone bodiesPrincipal Investigator

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The new therapy for cerebral infarction by modulating Keap1/Neaf2 system

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Astrocytic neuroprotective mechanism against diabetic encephalopathy through metabolic stress responsePrincipal Investigator

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Studies on cortical spreading depression and changes in brain capillary blood flow in acute phase of brain ischemia or aura in acute migraine

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[Book] Psychology and paho-physiological outcomes of eating2021

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Data Source

[Book] 脳血管の解剖;動脈系、静脈系(井林雪郎編)(ファーマナビゲーター脳卒中編)2006

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[Journal Article] Induced pluripotent stem cells‐based disease modeling, drug screening, clinical trials, and reverse translational research for amyotrophic lateral sclerosis2023

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[Journal Article] Phase 1/2a clinical trial in ALS with ropinirole, a drug candidate identified by iPSC drug discovery2023

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[Journal Article] Metabolic Contribution and Cerebral Blood Flow Regulation by Astrocytes in the Neurovascular Unit2022

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[Journal Article] Maiden voyage: induced pluripotent stem cell-based drug screening for amyotrophic lateral sclerosis2022

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[Journal Article] Neuroprotection and Disease Modification by Astrocytes and Microglia in Parkinson Disease2022

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DOI

Takahashi Shinichi 高橋慎一

TAKAHASHI Shinichi 高橋慎一

高橋慎一タカハシシンイチ

[Journal Article] 特集神経疾患のドラッグ･リポジショニング-新時代へ ALS治療薬候補としてのロピニロール塩酸塩2019