Tokumitsu Hiroshi 徳光浩

… Alternative Names

TOKUMITSU Hiorshi 徳光浩

TOKUMITSU Hiroshi 徳光浩

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Researcher Number	20237077
Other IDs
Affiliation (Current)	2025: 岡山大学, ヘルスシステム統合科学学域, 教授
Affiliation (based on the past Project Information) *help	2021 – 2025: 岡山大学, ヘルスシステム統合科学学域, 教授 2018 – 2020: 岡山大学, ヘルスシステム統合科学研究科, 教授 2012 – 2017: 岡山大学, 自然科学研究科, 教授 2014: 岡山大学, 自然科学研究, 教授 2007 – 2011: Kagawa University, 医学部, 准教授 … More 2003 – 2006: Kagawa University, Medicine, Associate Professor, 医学部, 助教授 2004: Kagawa University, Signal Transduction Sciences, Associated professor 2000 – 2002: 香川医科大学, 医学部, 助教授 1991 – 1992: Nagoya University, Assistant professor, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator Functional biochemistry / Basic Section 43030:Functional biochemistry-related / Functional biochemistry Except Principal Investigator Metabolomics / Basic Section 49030:Experimental pathology-related / Biofunction/Bioprocess / Bacteriology (including Mycology) / Bacteriology (including Mycology) / General pharmacology / Neurochemistry/Neuropharmacology
Keywords	Principal Investigator CaM-KK / 細胞内カルシウム / CaMKK / カルモデュリン / シグナル伝達 / タンパク質リン酸化酵素 / CREB / 細胞内情報伝達 / STO-609 / Calmodulin … More / タンパク質リン酸化反応 / 細胞内カルシウム情報伝達 / 酵素阻害剤 / calmodulin / Ca2+シグナル伝達 / TIM-063 / 阻害剤 / Numbl / Numb / CaM-KI / Intracellular calcium / MLCK-A / CaM-kinase / CaM-キナーゼ / リン酸化酵素カスケード / リン酸化反応 / AMPK / CaM-キナーゼカスケード / 多量体 / キナーゼ阻害剤 / 基質認識機構 / 分子間相互作用 / 酵素阻害薬 / 細胞内カルシウム信号系 / 精子 / CaMキナーゼカスケード / キナーゼ / 細胞内カルシウムシグナル伝達 / イソプロテレノール / cAMP / HeLa細胞 / PKA / PP1 / PP2A / CaMKKβ / TIM-062 / タンパク質脱リン酸化反応 / Protein phosphorylation / Signal transduction / CaM-kinase cascade / タンパク質リン酸化 / Protein kinase inhibitor / Protein kinase / タンパク質リン酸化酵素阻害剤 / C.elegans / Protein Kinase cascade / Sgnal Transduction / Intracellalr Calcium / 線虫 / 細胞内カルシウ / CaMK Cascade / 特異性 / CaMキナーゼI V / AMPキナーゼ / Signal Transduction / Protein Kinase / CaMK cascade / Wolframin症候群 / MS / LC-MS / WFS1 / 海馬 / 樹状突起 / カルシウム情報伝達 / シナプス / LC-MS/MS / 自己リン酸化 / 変異体 / ATPアナログ / Syndapin I / タンパク質リン酸化反 / LC-MS/ MS / GST / 機能プロテオミクス / PRG-1 / Wolframin / CaM-KIV / SAD-キナーゼ / CaMKKCaM-KIV … More Except Principal Investigator PREB / Clostridium perfringens / glucose / insulin / 糖尿病 / Epsilon-toxin / CaMKIV / グルコース / 膵β細胞 / インスリン / Inversin / 繊毛タンパク / 平面内細胞極性 / 一次繊毛 / 転写調節 / stem cell / IB1 / CaMKK / 脂質ラフト / ε毒素 / Histopathology / MDCK cell / Receptor / Nephrotoxicity / Lipid rafts / プロテインキナ-ゼ / 細胞内情報伝達系 / プロテインキナーゼ / シグナル伝達 / バイオテクノロジー / 転写活性 / 嚢胞腎 / 転写制御 / 繊毛虫 / 形態形成 / 転写活性調節 / 細胞極性 / シスト / 転写 / SRタンパク質 / 変異 / 抗体工学 / AID / DT40 / 細胞工学 / 抗体 / Diabetes mellitus / gene transcription / regeneration / pancreatic beta-cell / 遺伝子転写 / 再生 / Diabetes Mellitus / IB-1 / Sphingomyelin / Ganglioside / Signal transduction / Platelet aggregation / Lipid raft / Alpha-toxin / セラミド / スフィンゴ糖脂質 / 脂質クラフト / イプシロン毒素 / 血小板 / スフィンゴミエリン / ガングリオシド / 血小板凝集 / α毒素 / ウエルシュ菌 / Immunohistochemsitry / 膜孔形成型毒素 / モノクローナル抗体 / 腸性毒素血症 / 構造解析 / ウェルシュ菌 / Immunohistochemistry / Histoparhology / Inhibitor Data Base / Protein Kinase Inhibitor / Protein kinase / 阻害剤デ-タベ-ス / プロテインキナ-ゼ阻害剤 / 阻害剤データベース / プロテインキナーゼ阻害剤 / KN-62 / Protein Kinase / Ca^<2+> binding protein (s) / Protein phosphorylation / Myosin light chain phosphorylation / カルバスクリン / カルギザリン / カルシウム結合蛋白 / カルモデュリンキナ-ゼII / ミオシン脱リン酸化酵素 / KNー62 / Ca^<2+>結合蛋白質 / 蛋白質リン酸化反応 / ミオシン軽鎖リン酸化反応 / GLP-1 / ABCA1 / インスリン分泌 / 糖毒性 / 脂肪毒性 / HDL代謝 / 代謝学 / 分化誘導 / グルコース応答 / 膵β細胞の再生 / 転写因子 / Glucokinase / インスリン遺伝子 / 転写因子PREB / glucokinase / β細胞 / グルコース応答性 / 分子シャペロン / Tetratricopeptide repeat / Calmodulin / S100蛋白質 / カルシウム / 薬理学 / 創薬 / 分子標的薬 / 生体分子 / 神経科学 / バイオケミカルモデュレーション / W-77 / アドリアマイシン / グルタチオン-S-トランスフェラーゼ / P糖蛋白 / 薬剤耐性 / 卵巣癌 Less

新たなカルモデュリン制御リン酸化・脱リン酸化酵素の発見とシグナル伝達解析Principal Investigator
- Principal Investigator
  
  徳光浩
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43030:Functional biochemistry-related
- Research Institution
  Okayama University
Analysis of transcriptional control mechanism by cellular antennas
- Principal Investigator
  
  水津太
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  Kagawa University
Development of inhibitors based on CaMKK-mediated signal transductionPrincipal Investigator
- Principal Investigator
  
  Tokumitsu Hiroshi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 43030:Functional biochemistry-related
- Research Institution
  Okayama University
Regulatory mechanism of transcription by ciliary proteins.
- Principal Investigator
  
  Suizu Futoshi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  Kagawa University
  Hokkaido University
Regulation of CaMKKbeta/AMPK signaling and drug developmentPrincipal Investigator
- Principal Investigator
  
  Tokumitsu Hiroshi
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43030:Functional biochemistry-related
- Research Institution
  Okayama University
Improvement of an animal cell-displaying technology by using a splicing factor
- Principal Investigator
  
  Kanayama Naoki
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biofunction/Bioprocess
- Research Institution
  Okayama University
Phosphorylation-dependent regulatory mechanism of calmoudlin-kinase cascadePrincipal Investigator
- Principal Investigator
  
  Tokumitsu Hiroshi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional biochemistry
- Research Institution
  Okayama University
Therapeutic strategy for lipotoxicity of pancreatic beta-cells
- Principal Investigator
  
  MURAO Koji
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Kagawa University
Comprehensive identification and signal transduction analysis of calmodulin-targets by functional proteomicsPrincipal Investigator
- Principal Investigator
  
  TOKUMITSU Hiroshi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional biochemistry
- Research Institution
  Kagawa University
Identification and characterization of a novel target for CaM-kinase cascadePrincipal Investigator
- Principal Investigator
  
  TOKUMITSU Hiroshi
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional biochemistry
- Research Institution
  Kagawa University
Mechanisms of insulin gene expression and regeneration of pancreatic beta-cell
- Principal Investigator
  
  ISHIDA Toshihiko
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Kagawa University
The development of the molecular target drugs for intracellular calcium signal pathway
- Principal Investigator
  
  KOBAYASHI Ryoji
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Kagawa University
Analysis of calmodulin-kinase cascade by using functional proteomics.Principal Investigator
- Principal Investigator
  
  TOKUMITSU Hiroshi
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional biochemistry
- Research Institution
  Kagawa University
Regeneration of pancreatic beta-cells that secret insulin in response to glucose stimulation
- Principal Investigator
  
  ISHIDA Toshihiko
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Kagawa University
A study on the mechanism underlying the action of Clostridium perfringens alpha- and epsilon-toxins to membrane lipid rafts
- Principal Investigator
  
  OKABE Akinobu
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  KAGAWA UNIVERSITY
  香川大学(医学部)
Determine the molecular mechanism of insulin gene expression for the regeneration of pancreatic islets
- Principal Investigator
  
  ISHIDA Toshihiko
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Kagawa University
  香川大学(医学部)
Physiological function of calcium/calmodulin-dependent protein kinase cascadePrincipal Investigator
- Principal Investigator
  
  TOKUMITSU Hiroshi
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional biochemistry
- Research Institution
  Kagawa University(Faculty of Medicine)
Study on structure biology and molecular pathology of Clostridium perfringens epsilon-toxin
- Principal Investigator
  
  OKABE akinobu
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Kagawa Medical University
Regulation of gene expression mediated by Ca^<2+>/calmodulin-dependent protein kinase cascadePrincipal Investigator
- Principal Investigator
  
  TOKUMITSU Hiroshi
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional biochemistry
- Research Institution
  Kagawa Medical University
卵巣癌細胞における薬剤耐性克服薬の新規開発とその機能
- Principal Investigator
  
  HIDAKA Hiroyoshi
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Nagoya University
The Development of the Strategy for the Presumption of the Tertiary Structure of Protein Kinases by Specific Inhibitors
- Principal Investigator
  
  HIDAKA Hiroyoshi
- Project Period (FY)
  1990 – 1992
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  General pharmacology
- Research Institution
  Nagoya University
Unification and reconstruction of myosin phosphorylation theory on contractile response of smooth muscle and nonmuscle cells.
- Principal Investigator
  
  HIDAKA Hiroyoshi
- Project Period (FY)
  1989 – 1991
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Nagoya University

[Book] Methods Mol Biol.2019
- Author(s)
  Sakane K, Yamaguchi F, Tsuchiya M, Kondo R, Kanayama N, Magari M, Hatano N, Kobayashi R, Tokumitsu H.
- Total Pages
  11
- Publisher
  Humana Press, New York, NY
- ISBN
  9781493990290
- Data Source
  KAKENHI-PROJECT-18K06113
[Journal Article] Development of a novel AAK1 inhibitor via Kinobeads-based screening2024
- Author(s)
  Yoshida Akari、Ohtsuka Satomi、Matsumoto Fumiya、Miyagawa Tomoyuki、Okino Rei、Ikeda Yumeya、Tada Natsume、Gotoh Akira、Magari Masaki、Hatano Naoya、Morishita Ryo、Satoh Ayano、Sunatsuki Yukinari、Nilsson Ulf J.、Ishikawa Teruhiko、Tokumitsu Hiroshi
- Journal Title
  
  Scientific Reports
  
  Volume: 14 Issue: 1 Pages: 3726-3726
- DOI
  10.1038/s41598-024-57051-9
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02429
[Journal Article] Transcriptional, biochemical, and immunohistochemical analyses of CaMKKβ/2 splice variants that co-localize with CaMKIV in spermatids2024
- Author(s)
  Ohtsuka Satomi、Miyai Yumi、Mima Hiroyuki、Magari Masaki、Chiba Yoichi、Suizu Futoshi、Sakagami Hiroyuki、Ueno Masaki、Tokumitsu Hiroshi
- Journal Title
  
  Cell Calcium
  
  Volume: 117 Pages: 102820-102820
- DOI
  10.1016/j.ceca.2023.102820
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K10827, KAKENHI-PROJECT-21K04791, KAKENHI-PROJECT-21H02429
[Journal Article] Rapid detection of calmodulin/target interaction via the proximity biotinylation method2023
- Author(s)
  Nakamura Kento Nlandu、Yamauchi Haruki、Mima Hiroyuki、Chen Yerun、Ohtsuka Satomi、Magari Masaki、Morishita Ryo、Tokumitsu Hiroshi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 659 Pages: 29-33
- DOI
  10.1016/j.bbrc.2023.03.072
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K04791, KAKENHI-PROJECT-21H02429
[Journal Article] PHI-1, an Endogenous Inhibitor Protein for Protein Phosphatase-1 and a Pan-Cancer Marker, Regulates Raf-1 Proteostasis2023
- Author(s)
  Kirkbride Jason A.、Nilsson Garbo Young、Kim Jee In、Takeya Kosuke、Tanaka Yoshinori、Tokumitsu Hiroshi、Suizu Futoshi、Eto Masumi
- Journal Title
  
  Biomolecules
  
  Volume: 13 Issue: 12 Pages: 1741-1741
- DOI
  10.3390/biom13121741
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K06339, KAKENHI-PROJECT-23K06837, KAKENHI-PROJECT-21H02429
[Journal Article] Conformation-Dependent Reversible Interaction of Ca2+/Calmodulin-Dependent Protein Kinase Kinase with an Inhibitor, TIM-0632022
- Author(s)
  Satomi Ohtsuka;Taisei Okumura;Yuna Τabuchi;Tomoyuki Miyagawa;Naoki Kanayama;Masaki Magari;Naoya Hatano;Hiroyuki Sakagami;Futoshi Suizu;Teruhiko Ishikawa;Hiroshi Tokumitsu
- Journal Title
  
  Biochemistry
  
  Volume: 61(7) Issue: 7 Pages: 545-553
- DOI
  10.1021/acs.biochem.1c00796
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03447, KAKENHI-PROJECT-21J10565, KAKENHI-PROJECT-20K05231, KAKENHI-PROJECT-21K04791
[Journal Article] Substrate recognition by Arg/Pro‐rich insert domain in calcium/calmodulin‐dependent protein kinase kinase for target protein kinases2022
- Author(s)
  Kaneshige Riku、Ohtsuka Satomi、Harada Yuhei、Kawamata Issei、Magari Masaki、Kanayama Naoki、Hatano Naoya、Sakagami Hiroyuki、Tokumitsu Hiroshi
- Journal Title
  
  The FEBS Journal
  
  Volume: 289 Issue: 19 Pages: 5971-5984
- DOI
  10.1111/febs.16467
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K05231, KAKENHI-PROJECT-21K04791, KAKENHI-PROJECT-21H02429
[Journal Article] Conformation-Dependent Reversible Interaction of Ca2+/Calmodulin-Dependent Protein Kinase Kinase with an Inhibitor, TIM-0632022
- Author(s)
  Satomi Ohtsuka, Taisei Okumura, Yuna Τabuchi, Tomoyuki Miyagawa, Naoki Kanayama, Masaki Magari, Naoya Hatano, Hiroyuki Sakagami, Futoshi Suizu, Teruhiko Ishikawa, Hiroshi Tokumitsu
- Journal Title
  
  Biochemistry
  
  Volume: 61 Pages: 545-553
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H02429
[Journal Article] Molecular Mechanisms Underlying Ca2+/Calmodulin-Dependent Protein Kinase Kinase Signal Transduction2022
- Author(s)
  Tokumitsu Hiroshi、Sakagami Hiroyuki
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 23 Issue: 19 Pages: 11025-11025
- DOI
  10.3390/ijms231911025
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H02429
[Journal Article] The immunoreceptor <scp>SLAMF8</scp> promotes the differentiation of follicular dendritic cell‐dependent monocytic cells with B cell‐activating ability2022
- Author(s)
  Magari Masaki、Nishioka Miku、Hari Tomomi、Ogawa Sayaka、Takahashi Kaho、Hatano Naoya、Kanayama Naoki、Futami Junichiro、Tokumitsu Hiroshi
- Journal Title
  
  FEBS Letters
  
  Volume: 596 Issue: 20 Pages: 2659-2667
- DOI
  10.1002/1873-3468.14468
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K05231, KAKENHI-PROJECT-21K04791, KAKENHI-PROJECT-21H02429
[Journal Article] Oligomerization of Ca2+/calmodulin-dependent protein kinase kinase.2022
- Author(s)
  Yusei Fukumoto, Yuhei Harada, Satomi Ohtsuka, Naoki Kanayama, Masaki Magari, Naoya Hatano, Hiroyuki Sakagami, Hiroshi Tokumitsu
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 587 Pages: 160-165
- DOI
  10.1016/j.bbrc.2021.11.105
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H02429, KAKENHI-PROJECT-20K05231
[Journal Article] A temporal Ca<sup>2+</sup> desensitization of myosin light chain kinase in phasic smooth muscles induced by CaMKKβ/PP2A pathways2021
- Author(s)
  Kitazawa Toshio、Matsui Toshiyasu、Katsuki Shuichi、Goto Akira、Akagi Kai、Hatano Naoya、Tokumitsu Hiroshi、Takeya Kosuke、Eto Masumi
- Journal Title
  
  American Journal of Physiology-Cell Physiology
  
  Volume: 321 Issue: 3 Pages: C549-C558
- DOI
  10.1152/ajpcell.00136.2021
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07279, KAKENHI-PROJECT-21H02429, KAKENHI-PROJECT-19K06573
[Journal Article] Development and Characterization of Novel Molecular Probes for Ca2+/Calmodulin-Dependent Protein Kinase Kinase, Derived from STO-609.2020
- Author(s)
  Ohtsuka S, Ozeki Y, Fujiwara M, Miyagawa T, Kanayama N, Magari M, Hatano N, Suizu F, Ishikawa T, and Tokumitsu H.
- Journal Title
  
  Biochemistry
  
  Volume: 59(17) Issue: 17 Pages: 1701-1710
- DOI
  10.1021/acs.biochem.0c00149
- NAID
  120007027579
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03447, KAKENHI-PROJECT-18K02255, KAKENHI-PROJECT-18K06113
[Journal Article] Phosphorylation and dephosphorylation of Ca2+/calmodulin-dependent protein kinase kinase β at Thr144 in HeLa cells2020
- Author(s)
  Takabatake Shota、Fukumoto Yusei、Ohtsuka Satomi、Kanayama Naoki、Magari Masaki、Sakagami Hiroyuki、Hatano Naoya、Tokumitsu Hiroshi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 525 Issue: 1 Pages: 251-257
- DOI
  10.1016/j.bbrc.2020.02.056
- NAID
  120006961125
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K02255, KAKENHI-PROJECT-18K06113
[Journal Article] Regulation of Ca2+/calmodulin-dependent protein kinase kinase β by cAMP signaling.2019
- Author(s)
  Takabatake S, Ohtsuka S, Sugawara T, Hatano N, Kanayama N, Magari M, Sakagami H, Tokumitsu H.
- Journal Title
  
  Biochim Biophys Acta Gen Subj.
  
  Volume: 1863 Issue: 4 Pages: 672-680
- DOI
  10.1016/j.bbagen.2018.12.012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06113, KAKENHI-PROJECT-15H04196
[Journal Article] Interaction of S100A6 with Target Proteins In Vitro and in Living Cells2019
- Author(s)
  Sakane Kyohei、Yamaguchi Fuminori、Tsuchiya Mitsumasa、Kondo Rina、Kanayama Naoki、Magari Masaki、Hatano Naoya、Kobayashi Ryoji、Tokumitsu Hiroshi
- Journal Title
  
  Methods in Molecular Biology
  
  Volume: 1929 Pages: 367-377
- DOI
  10.1007/978-1-4939-9030-6_23
- ISBN
  9781493990290, 9781493990306
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H04196, KAKENHI-PROJECT-19J12975
[Journal Article] Interleukin 34 (IL-34) cell-surface localization regulated by the molecular chaperone 78-kDa glucose-regulated protein facilitates the differentiation of monocytic cells2018
- Author(s)
  Ogawa Sayaka、Matsuoka Yukiko、Takada Miho、Matsui Kazue、Yamane Fumihiro、Kubota Eri、Yasuhara Shiori、Hieda Kentaro、Kanayama Naoki、Hatano Naoya、Tokumitsu Hiroshi、Magari Masaki
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 294 Issue: 7 Pages: 2386-2396
- DOI
  10.1074/jbc.ra118.006226
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K04852, KAKENHI-PROJECT-15H04196
[Journal Article] Ca2＋/calmodulin-dependent protein kinase kinase2018
- Author(s)
  徳光　浩
- Journal Title
  
  生化学
  
  Volume: 90 Issue: 4 Pages: 452-461
- DOI
  10.14952/SEIKAGAKU.2018.900452
- ISSN
  0037-1017
- Year and Date
  2018-08-25
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06113
[Journal Article] Identification and characterization of a centrosomal protein, FOR20 as a novel S100A6 target2017
- Author(s)
  Kyohei Sakane, Miyu Nishiguchi, Miwako Denda, Fuminori Yamagchi, Masaki Magari, Naoki Kanayama, Ryo Morishita, Hiroshi Tokumitsu
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 491 Issue: 4 Pages: 980-985
- DOI
  10.1016/j.bbrc.2017.07.161
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H04196, KAKENHI-PROJECT-16K14783
[Journal Article] SRSF1-3 contributes to diversification of the immunoglobulin variable region gene by promoting accumulation of AID in the nucleus2017
- Author(s)
  Yuka Kawaguchi, Hiroaki Nariki, Naoko Kawamoto, Yuichi Kanehiro, Satoshi Miyazaki, Mari Suzuki, Masaki Magari, Hiroshi Tokumitsu, Naoki Kanayama
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 485 Issue: 2 Pages: 261-266
- DOI
  10.1016/j.bbrc.2017.02.097
- NAID
  120006425839
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H04196, KAKENHI-PROJECT-16K14783
[Journal Article] AMP-activated protein kinase-mediated feedback phosphorylation controls the Ca2+/calmodulin (CaM) dependence of Ca2+/CaM-dependent protein kinase kinase β2017
- Author(s)
  Akihiro Nakanishi, Naoya Hatano, Yuya Fujiwara, Arian Sha'ri, Shota Takabatake, Hiroki Akano, Naoki Kanayama, Masaki Magari, Naohito Nozaki, Hiroshi Tokumitsu
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 292 Issue: 48 Pages: 19804-19813
- DOI
  10.1074/jbc.m117.805085
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H04196, KAKENHI-PROJECT-16K14783
[Journal Article] Differential AMP-activated Protein Kinase (AMPK) Recognition Mechanism of Ca2+/Calmodulin-dependent Protein Kinase Kinase Isoforms.2016
- Author(s)
  Yuya Fujiwara, Yoshinori Kawaguchi, Tomohito Fujimoto, Naoki Kanayama, Masaki Magari, Hiroshi Tokumitsu
- Journal Title
  
  The Journal of biological chemistry
  
  Volume: 291 Issue: 26 Pages: 13802-13808
- DOI
  10.1074/jbc.m116.727867
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H04196, KAKENHI-PROJECT-26440056
[Journal Article] Identification of striated muscle activator of Rho signaling (STARS) as a novel calmodulin target by a newly developed genome-wide screen.2016
- Author(s)
  Yusui Furuya, Miwako Denda, Kyohei Sakane, Tomoko Ogusu, Sumio Takahashi, Masaki Magari, Naoki Kanayama, Ryo Morishita, Hiroshi Tokumitsu
- Journal Title
  
  Cell calcium
  
  Volume: 60 Issue: 1 Pages: 32-40
- DOI
  10.1016/j.ceca.2016.04.004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H04196, KAKENHI-PROJECT-26440056, KAKENHI-PROJECT-26440167
[Journal Article] Oxidative Stress Impairs the Stimulatory Effect of S100 Proteins on Protein Phosphatase 5 Activity2016
- Author(s)
  Yamaguchi F, Tsuchiya M, Shimamoto S, Fujimoto T, Tokumitsu H, Tokuda M, and Kobayashi R
- Journal Title
  
  Tohoku J. Exp. Med.
  
  Volume: 240 Issue: 1 Pages: 67-78
- DOI
  10.1620/tjem.240.67
- NAID
  130006776928
- ISSN
  0040-8727, 1349-3329
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26440056
[Journal Article] Compartmentalized AMPK Signaling Illuminated by Genetically Encoded Molecular Sensors and Actuators2015
- Author(s)
  Miyamoto T, Rho E, Sample V, Akano H, Magari M, Ueno T, Gorshkov K, Chen M, Tokumitsu H, Zhang J, Inoue T
- Journal Title
  
  Cell Reports
  
  Volume: 印刷中 Issue: 4 Pages: 657-670
- DOI
  10.1016/j.celrep.2015.03.057
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26440056
[Journal Article] Analysis of Distinct Roles of CaMKK Isoforms using STO-609-Resistant Mutants in Living Cells.2015
- Author(s)
  Fujiwara Y, Hiraoka Y, Fujimoto T, Kanayama N, Magari M, Tokumitsu H.
- Journal Title
  
  Biochemistry
  
  Volume: 54 Issue: 25 Pages: 3969-3977
- DOI
  10.1021/acs.biochem.5b00149
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26440056, KAKENHI-PROJECT-15H04196, KAKENHI-PROJECT-26650126
[Journal Article] NUMB phosphorylation destabilizes p53 and promotes self-renewal of tumor-initiating cells by a NANOG-dependent mechanism in liver cancer.2015
- Author(s)
  Siddique HR, Feldman DE, Chen CL, Punj V, Tokumitsu H, Machida K.
- Journal Title
  
  Hepatology
  
  Volume: 62 Issue: 5 Pages: 1466-1479
- DOI
  10.1002/hep.27987
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26440056
[Journal Article] Oxidized S100A4 inhibits the activation of protein phosphatase 5 through S100A1 in MKN‑45 gastric carcinoma cells2014
- Author(s)
  Tsuchiya M, Yamaguchi F, Shimamoto S, Fujimoto T, Tokumitsu H, Tokuda M, Kobayashi R
- Journal Title
  
  International Journal of Molecular Medicine
  
  Volume: 34 Issue: 6 Pages: 1713-1719
- DOI
  10.3892/ijmm.2014.1947
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26440056
[Journal Article] S100 proteins modulate protein phosphatase 5 function : a link between Ca^<2+> signal transduction and protein dephosphorylation2012
- Author(s)
  Yamaguchi F, Umeda Y, Shimamoto S, Tsuchiya M, Tokumitsu H, Tokuda M, and Kobayahsi R
- Journal Title
  
  J. Biol. Chem
  
  Volume: (掲載確定)
- Data Source
  KAKENHI-PROJECT-21570143
[Journal Article] Local application of neurotrophins specifies axons through inositol 1, 4, 5-trisphosphate, calcium, and Ca^<2+>/ calmodulin. dependent protein kinases2011
- Author(s)
  Nakamuta S, Funahashi Y, Namba T, Arimura N, Picciotto MR, Tokumitsu H, Soderling TR, Sakakibara A, Miyata T, Kamiguchi H, and Kaibuchi K
- Journal Title
  
  Sci. Signal
  
  Volume: 4
- Data Source
  KAKENHI-PROJECT-21570143
[Journal Article] Identification of a novel CaMKK substrate2011
- Author(s)
  Fujimoto T, Hatano N, Nozaki N, Yurimoto S, Kobayashi R, and Tokumitsu H
- Journal Title
  
  Biochem. Biophys. Res. Comm
  
  Volume: 410 Pages: 45-51
- Data Source
  KAKENHI-PROJECT-21570143
[Journal Article] Exendin-4 regulates GLUT2 expression via the CaMKK/ CaMKIV pathway in a pancreatic beta-cell line2011
- Author(s)
  Chen K, Yu X, Murao K, Imachi H, Li J, Muraoka T, Masugata H, Zhang GX, Kobayashi R, Ishida T, and Tokumitsu H
- Journal Title
  
  Metabolism
  
  Volume: 60 Pages: 579-585
- Data Source
  KAKENHI-PROJECT-21570143
[Journal Article] Generation of Autonomous Activity of Ca^<2+>/ Calmodulin-Dependent Protein Kinase Kinaseβby Autophosphorylation2011
- Author(s)
  Tokumitsu H, Hatano N, Fujimoto T, Yurimoto S, and Kobayashi R
- Journal Title
  
  Biochemistry
  
  Volume: 50 Pages: 8193-8201
- Data Source
  KAKENHI-PROJECT-21570143
[Journal Article] Generation of Autonomous Activity of Ca^<2+>/Calmodulin-Dependent Protein Kinase Kinase β by Autophosphorylation2011
- Author(s)
  Tokumitsu H, et al
- Journal Title
  
  Biochemistry
  
  Volume: 50 Issue: 38 Pages: 8193-8201
- DOI
  10.1021/bi201005g
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21570143, KAKENHI-PROJECT-23501296
[Journal Article] Analysis of CaM-kinase Signaling in Cells2011
- Author(s)
  Wayman GA, Tokumitsu H, Davare MA, and Soderling TR
- Journal Title
  
  Cell Calcium
  
  Volume: 50 Pages: 1-8
- Data Source
  KAKENHI-PROJECT-21570143
[Journal Article] Eya1 controls cell polarity, spindle orientation, cell fate and Notch signaling in distal embryonic lung epithelium2011
- Author(s)
  El-Hashash AH, Turcatel G, Al Alam D, Buckley S, Tokumitsu H, Bellusci S, and Warburton D
- Journal Title
  
  Development
  
  Volume: 138 Pages: 1395-1407
- Data Source
  KAKENHI-PROJECT-21570143
[Journal Article] Identification and characterization of PRG-1 as a neuronal calmodulin-binding protein.2010
- Author(s)
  Tokumitsu, et al.
- Journal Title
  
  Biochemical Journal
  
  Volume: 431 Pages: 81-91
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21570143
[Journal Article] S100 proteins regulate the interaction of Hsp90 with Cyclophilin 40 and FKBP52 through their tetratricopeptide repeats2010
- Author(s)
  Shimamoto S, Kubota Y, Tokumitsu H, and Kobayashi R
- Journal Title
  
  FEBS Lett
  
  Volume: 584 Pages: 1119-1125
- Data Source
  KAKENHI-PROJECT-21570143
[Journal Article] Inactivation of Ca^<2+>/ calmodulin-dependent protein kinase I by S-glutathionylation of the active-site cysteine residue2010
- Author(s)
  Kambe T, Song T, Takata T, Hatano N, Miyamoto Y, Nozaki N, Naito Y, Tokumitsu H, and Watanabe Y
- Journal Title
  
  FEBS Lett
  
  Volume: 584 Pages: 2478-2484
- Data Source
  KAKENHI-PROJECT-21570143
[Journal Article] Regulation of nuclear localization signal-importin・interaction by Ca^<2+>/ S100A62010
- Author(s)
  Takata M, Shimamoto S, Yamaguchi F, Tokuda M, Tokumitsu H, and Kobayashi R
- Journal Title
  
  FEBS Lett
  
  Volume: 584 Pages: 4517-4523
- Data Source
  KAKENHI-PROJECT-21570143
[Journal Article] Exendin-4 regulates pancreatic ABCA1 transcription via CaMKK/ CaMKIV pathway2010
- Author(s)
  Li J, Murao K, Imachi H, Masugata H, Iwama H, Tada S, Zhang GX, Kobayashi R, Ishida T, and Tokumitsu H
- Journal Title
  
  J. Cell. Mol. Med
  
  Volume: 14 Pages: 1083-1087
- Data Source
  KAKENHI-PROJECT-21570143
[Journal Article] Exendin-4 regulates Glucokinase expression via CaMKK/CaMKIV pathway in pancreatic β cell line2009
- Author(s)
  Murao K, Li J, Imachi H, Muraoka T, Masugata H, Zhang GX, Kobayashi R, Ishida T and Tokumitsu H
- Journal Title
  
  Diabetes, Obesity and Metabolism
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18300123
[Journal Article] Breast cancer cells with stem cell-type markers (CD44+ CD24lo ) are eliminated by Notch and Numb peptide -activated T cells2009
- Author(s)
  Mine T, Matsueda S, Tokumitsu H, Gao H, Danes C, and Ioannides C.G.
- Journal Title
  
  Cancer Immunology Immunotherapy (掲載確定)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19570134
[Journal Article] Exendin-4 regulates glucokinase expression by CaMKK/ CaMKIV pathway in pancreatic beta-cell line2009
- Author(s)
  Murao K, Li J, Imachi H, Muraoka T, Masugata H, Zhang GX, Kobayashi R, Ishida T, and Tokumitsu H
- Journal Title
  
  Diabetes Obes. Metab
  
  Volume: 11 Pages: 939-946
- Data Source
  KAKENHI-PROJECT-21570143
[Journal Article] dentification and Characterization of Wolframin, the Product of the Wolfram Syndrome Gene (WFS1), as a Novel Calmodulin-Binding Protein2009
- Author(s)
  Yurimoto S, Hatano N, Tsuchiya M, Kato K, Fujimoto T, Masaki T, Kobayashi R. and Tokumitsu H
- Journal Title
  
  Biochemistry 48(18)
  
  Pages: 3946-3955
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18300123
[Journal Article] Identification and characterization of wolframin, the product of the wolfram syndrome gene(WFS1), as a novel calmodulin-binding protein2009
- Author(s)
  Yurimoto S, Hatano N, Tsuchiya M, Kato K, Fujimoto T, Masaki T, Kobayashi R, and Tokumitsu H
- Journal Title
  
  Biochemistry
  
  Volume: 48 Pages: 3946-3955
- Data Source
  KAKENHI-PROJECT-21570143
[Journal Article] Breast cancer cells expressing stem cell markers CD44+ CD24 lo are eliminated by Numb-1 peptide-activated T cells2009
- Author(s)
  Mine T, Matsueda S, Li Y, Tokumitsu H, Gao H, Danes C, Wong KK, Wang X, Ferrone S, and Ioannides CG
- Journal Title
  
  Cancer Immunol. Immunother
  
  Volume: 58 Pages: 1185-1194
- Data Source
  KAKENHI-PROJECT-21570143
[Journal Article] The Role of Calcium/Calmodulin-Dependent Protein Kinase Cascade on MIP-1α Gene Expression of ATL Cells2008
- Author(s)
  Matsumoto K, Murao K, Imachi H, Nishiuchi T, Cao WM, Yu X, Li J, Ahmed RA, Iwama H, Kobayashi R, Tokumitsu H, Ishida T
- Journal Title
  
  Experimental Hematology 36
  
  Pages: 390-400
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591054
[Journal Article] 14-3-3 proteins directly regulate Ca2+/calmodulin-dependent protein kinase kinaseαthrough phosphorylation- dependent multisite binding2008
- Author(s)
  Ichimura T, Taoka M, Hozumi Y, Goto K, and Tokumitsu H
- Journal Title
  
  FEBS Letters 582(5)
  
  Pages: 661-665
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19570134
[Journal Article] Activation of SAD Kinase by Ca2+/Calmodulin-dependent Protein Kinase Kinase2008
- Author(s)
  Fujimoto T, Yurimoto S, Hatano N, Nozaki N, Sueyoshi N, Kameshita I, Mizutani A, Mikoshiba K, Kobayashi R, and Tokumitsu H
- Journal Title
  
  Biochemistry 47 (13)
  
  Pages: 4151-4159
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18300123
[Journal Article] Interactions of S100A2 and S100A6 with the tetratricopeptide repeat proteins, Hsp90 /Hsp70-organizing protein and kinesin- light chain2008
- Author(s)
  Shimamoto S, Takata M, Tokuta M, Oohira F, Tokumitsu H, and Kobayashi R
- Journal Title
  
  Journal of Biological Chemistry 83(42)
  
  Pages: 28246-28258
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18300123
[Journal Article] Activation of SAD Kinase by Ca2+/Calmodulin-dependent Protein Kinase Kinase2008
- Author(s)
  Fujimoto T, Yurimoto S, Hatano N, Nozaki N, Sueyoshi N, Kameshita I, Mizutani A, Mikoshiba K, Kobayashi R, and Tokumitsu H
- Journal Title
  
  Biochemistry 47(13)
  
  Pages: 4151-4159
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19570134
[Journal Article] Calmodulin-kinases2008
- Author(s)
  Wayman G. A., Lee Y-S., Tokumitsu H, Silva A, and Soderling T. R.
- Journal Title
  
  Modulators of Neuronal Development and Plasticity Neuron 59(6)
  
  Pages: 914-931
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19570134
[Journal Article] The Role of Calcium/Calmodulin-Dependent Protein Kinase Cascade on MIP-1a Gene Expression of ATL Cells2008
- Author(s)
  Matsumoto K, Murao K, Imachi H, Nishiuchi T, Cao W M, Yu X, Li J, Ahmed R A M, Iwama H, Tokumitsu H, and Ishida T
- Journal Title
  
  Experimental Hematology 36(4)
  
  Pages: 390-400
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19570134
[Journal Article] The Role of Calcium/Calmodulin -Dependent Protein Kinase Cascade on MIP-1a Gene Expression of ATL Cells2008
- Author(s)
  Matsumoto K, Murao K, Imachi H, Nishiuchi T, Cao W M, Yu X, Li J, Ahmed R A M, Iwama H, Kobayashi R, Tokumitsu H, and Ishida T
- Journal Title
  
  Experimental Hematology 36(4)
  
  Pages: 390-400
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18300123
[Journal Article] Interactions of S100A2 and S100A6 with the tetratricopeptide repeat proteins Hsp90/Hsp70-organizing protein and kinesin-light chain2008
- Author(s)
  Shimamoto S, Takata M, Tokuta M, Oohira F, Tokumitsu H, and Kobayashi R
- Journal Title
  
  Journal of Biological Chemistry 83(42)
  
  Pages: 28246-28258
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19570134
[Journal Article] Knockdown of nuclear Ca^<2+>/calmodulin-dependent protein kinase phosphatase causes developmental abnormalities in zebrafish.2007
- Author(s)
  T.Nimura, N.Sueyoshi, A.Ishida, Y.Yoshimura, M.Ito, H.Tokumitsu, Y.Shigeri, N.Nozaki, I.Kameshita
- Journal Title
  
  Archives of Biochemistry and Biophysics 457(2)
  
  Pages: 205-216
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17570115
[Journal Article] Spatiotemporal expression of four isoforms of Ca^<2+>/calmodulin-dependent protein kinase I in brain and its possible roles in hippocampal dendritic growth.2007
- Author(s)
  A.Kamata, H.Sakagami, H.Tokumitsu, Y.Owada, K.Fukunaga, H.Kondo
- Journal Title
  
  Neuroscience Research 57(1)
  
  Pages: 86-97
- NAID
  10021188190
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17570115
[Journal Article] Distinct developmental expression of two isoforms of Ca2+/calmodulin-dependent protein kinase kinases2007
- Author(s)
  Kamata A, Sakagami H, Tokumitsu H, Sanda M, Owada Y, Fukunaga K, and Kondo H
- Journal Title
  
  Neuroscience Letters 423(2)
  
  Pages: 143-148
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19570134
[Journal Article] Phosphorylation of Numb regulates its interaction with the clathrin-associated adaptor AP-2.2006
- Author(s)
  Hiroshi Tokumitsu et al.
- Journal Title
  
  FEBS Letters 580
  
  Pages: 5797-5801
- NAID
  120007015428
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17570115
[Journal Article] Phosphorylation of Numb regulates its interaction with the clathrin-associated adaptor AP-2.2006
- Author(s)
  H.Tokumitsu, N.Hatano, S.Yokokura, Y.Sueyoshi, N.Nozaki, R.Kobayashi
- Journal Title
  
  FEBS Letters 580(24)
  
  Pages: 5797-5801
- NAID
  120007015428
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17570115
[Journal Article] Phosphorylation of Numb regulates its interaction with the clathrin-associated adaptor AP-2.2006
- Author(s)
  H.Tokumitsu
- Journal Title
  
  FEBS Letters 580
  
  Pages: 5797-5801
- NAID
  120007015428
- Data Source
  KAKENHI-PROJECT-18300123
[Journal Article] Phosphorylation of Numb family proteins. : Possible involvement of Ca^<2+>/calmodulin-dependent protein kinases.2005
- Author(s)
  H.Tokumitsu, N.Hatano, H.Inuzuka, Y.Sueyoshi, S.Yokokura, T.Ichimura, N.Nozaki, R.Kobayashi
- Journal Title
  
  Journal of Biological Chemistry 280(42)
  
  Pages: 35108-35118
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17570115
[Journal Article] Phosphorylation of Numb family proteins. : Possible involvement of Ca^<2+>/calmodulin-dependent protein kinases.2005
- Author(s)
  Hiroshi Tokumitsu et al.
- Journal Title
  
  Journal of Biological Chemistry 280
  
  Pages: 35108-35118
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17570115
[Journal Article] Phosphorylation of Numb family proteins :Possible involvement of Ca^<2+>/calmodulin-dependent protein kinases.2005
- Author(s)
  Hiroshi Tokumitsu et al.
- Journal Title
  
  Journal of Biological Chemistry 280
  
  Pages: 35108-35118
- Data Source
  KAKENHI-PROJECT-17570115
[Journal Article] Role of calcium-calmodulin dependent protein kinase cascade in TRH upregulation of TSH and PRL gene expression.2004
- Author(s)
  Murao K, Imachi H, Yu X, Cao WM, Tokumitsu H, Inuzuka H, Wong NCW, Shupnik MA, Kobayashi R, Ishida T.
- Journal Title
  
  Endocrinology 145
  
  Pages: 4846-4852
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590944
[Journal Article] The role of calcium/calmodulin-dependent protein kinase cascade in glucose upregulation of insulin gene expression.2004
- Author(s)
  Yu X, Murao K, Sayo Y, Imachi H, Cao WM, Ohtsuka S, Niimi M, Tokumitsu H, Inuzuka H, Wong NC, Kobayashi R, Ishida T.
- Journal Title
  
  Diabetes. 53
  
  Pages: 1475-1481
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590944
[Journal Article] Exendin-4 regulates Glucokinase expression via CaMKK/CaMKIV pathway in pancreatic β cell line
- Author(s)
  Murao K, Li J, Imachi H, Muraoka T, Masugata H, Zhang GX, Kobayashi R, Ishida T, Tokumitsu H.
- Journal Title
  
  Diabetes Obesity & Metabolism
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591054
[Presentation] 近接ビオチン化法を用いた新規 Calmodulin 相互作用キナーゼの同定2023
- Author(s)
  山内陽生、中村謙仁ンランドウ、傳田美和子、杉山修世、大塚里美、曲正樹、森下了、徳光浩
- Organizer
  第64回日本生化学会中国・四国支部例会（松山)
- Data Source
  KAKENHI-PROJECT-21H02429
[Presentation] マウスCaMKKβ スプライシングバリアントの生化学的・組織学的解析2023
- Author(s)
  大塚里美、宮井由美、美馬光志、曲正樹、千葉陽一、水津太、阪上洋行、上野正樹、徳光浩
- Organizer
  第96回日本生化学会大会（福岡）
- Data Source
  KAKENHI-PROJECT-21H02429
[Presentation] CaMKKの基質認識機構の解明と特異的阻害分子開発への応用2022
- Author(s)
  川俣一晟、美馬光志、山内陽生、北前勝哉、山内香奈、大塚里美、曲正樹、金山直樹、徳光浩
- Organizer
  第95回　日本生化学会大会
- Data Source
  KAKENHI-PROJECT-21H02429
[Presentation] キナーゼ阻害剤プロテオミクス法を用いた薬効再評価法の開発2022
- Author(s)
  大塚里美、吉田朱里、波多野直哉、奥村太晟、澤直樹、田邊史子、傳田美和子、金山直樹、曲正樹、森下了、石川彰彦、徳光浩
- Organizer
  第95回　日本生化学会大会
- Data Source
  KAKENHI-PROJECT-21H02429
[Presentation] 新規CaMKK阻害剤TIM-063を用いたDrug-repositioning法の開発2022
- Author(s)
  吉田朱里、大塚里美、泥谷直、田邊史子、森下了、曲正樹、金山直樹、徳光浩
- Organizer
  第63回　日本生化学会中国・四国支部例会
- Data Source
  KAKENHI-PROJECT-21H02429
[Presentation] CaMKK阻害剤(TIM-063)を用いた阻害剤プロテオミクス解析2021
- Author(s)
  大塚里美, 波多野直哉, 奥村太晟, 澤直樹, 田邊史子, 傳田美和子, 金山直樹, 曲正樹, 森下了, 石川彰彦, 徳光浩
- Organizer
  第94回日本生化学大会（横浜・オンライン）
- Data Source
  KAKENHI-PROJECT-21H02429
[Presentation] 新規CaMKK阻害剤結合担体を用いた酵素・阻害剤相互作用解析2021
- Author(s)
  大塚里美, 波多野直哉, 奥村太晟, 澤直樹, 金山直樹, 曲正樹, 石川彰彦, 徳光浩
- Organizer
  第62回日本生化学会中国・四国支部例会（岡山）
- Data Source
  KAKENHI-PROJECT-21H02429
[Presentation] Ca2+/Calmodulin-dependent protein kinase kinase (CaMKK)の多量体形成2021
- Author(s)
  福本侑世, 原田裕平, 波多野直哉, 曲正樹, 金山直樹, 徳光浩
- Organizer
  第62回日本生化学会中国・四国支部例会（岡山）
- Data Source
  KAKENHI-PROJECT-21H02429
[Presentation] CaMKK基質認識におけるArg/Pro領域(RP-domain)の役割2021
- Author(s)
  兼重陸, 川俣一晟, 大塚里美, 波多野直哉, 曲正樹, 金山直樹, 徳光浩
- Organizer
  第94回日本生化学大会（横浜・オンライン）
- Data Source
  KAKENHI-PROJECT-21H02429
[Presentation] 分子プローブとしてのCa2+/calmodulin-dependent protein kinase kinase 新規阻害剤と不活性類縁体の開発2020
- Author(s)
  大塚　里美、尾関　唯、藤原　萌乃、宮川　知之、金山　直樹、曲　正樹、波多野　直哉、石川　彰彦、徳光　浩
- Organizer
  第６１回日本生化学会中国・四国支部例会
- Data Source
  KAKENHI-PROJECT-18K06113
[Presentation] CaMKKβのリン酸化/脱リン酸化による動的制御機構の解明2019
- Author(s)
  高畠　翔太、福本　侑世、金山　直樹、曲　正樹、波多野　直哉、徳光　浩
- Organizer
  第39回　日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18K06113
[Presentation] スプライシング因子の過剰発現及び標的遺伝子配列の操作によるニワトリ B 細胞株における遺伝子変異の増強2018
- Author(s)
  金山直樹, 太田愛美, 西山由美子, 岡知里, 曲正樹, 徳光浩
- Organizer
  第70回日本生物工学会大会
- Data Source
  KAKENHI-PROJECT-15H04196
[Presentation] CaMKKβシグナル伝達のAMPKおよびPKAによるリン酸化制御機構の解明2018
- Author(s)
  大塚里美, 高畠翔太, 金山直樹, 曲正樹, 徳光浩
- Organizer
  第９１回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-18K06113
[Presentation] GRP78により発現制御される濾胞樹状細胞表面のIL-34が単球系細胞の分化に関与する2018
- Author(s)
  小川紗也香, 松岡由希子, 高田美帆, 松井一恵, 山根文寛, 安原詩織, 金山直樹, 波多野直哉, 徳光浩, 曲正樹
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-15H04196
[Presentation] CaMKKβシグナル伝達のAMPKおよびPKAによるリン酸化制御機構の解明2018
- Author(s)
  大塚里美, 高畠翔太, 金山直樹, 曲正樹, 徳光浩
- Organizer
  第91回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-15H04196
[Presentation] AID発現とSHM誘導におけるBCRシグナルの役割2017
- Author(s)
  梶浦雄也、金廣優一、曲正樹、徳光浩、金山直樹
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-15H04196
[Presentation] 抗体遺伝子変異能力を操作できるニワトリB細胞を用いた動物細胞ディスプレイ2017
- Author(s)
  金山直樹, 太田愛美, 西山由美子, 清木俊雄, 植月英智, 川口祐加, 仲尾祐輝, 曲正樹, 徳光浩
- Organizer
  第69回日本生物工学会大会
- Data Source
  KAKENHI-PROJECT-15H04196
[Presentation] スプライシング因子の過剰発現及び標的遺伝子配列の操作によるニワトリB細胞株における遺伝子変異の増強2017
- Author(s)
  太田愛美、西山由美子、曲正樹、徳光浩、金山直樹
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-15H04196
[Presentation] 抗体遺伝子変異の転写関連過程におけるSRSF1-3の役割の解析2017
- Author(s)
  金山直樹、川口祐加、横山和輝、石橋朋之、曲正樹、徳光浩
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-15H04196
[Presentation] SRSF1-3の高度保存領域が抗体遺伝子変異に寄与する2016
- Author(s)
  成木弘明、川口祐加、宮崎誠士、河本奈緒子、横山和輝、徳光浩、曲正樹、金山直樹
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-12-02
- Data Source
  KAKENHI-PROJECT-15H04196
[Presentation] 抗体遺伝子高頻度突然変異におけるssDNA形成へのSRSF1-3の関与の解析2016
- Author(s)
  横山和輝、川口祐加、松山雄磨、河本奈緒子、成木弘明、徳光浩、曲正樹、金山直樹
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-12-02
- Data Source
  KAKENHI-PROJECT-15H04196
[Presentation] スプライシング因子過剰発現による B 細胞株における抗体遺伝子変異の増強2016
- Author(s)
  太田愛美, 西山由美子, 清木俊雄, 植月英智, 川口祐加, 仲尾祐輝, 曲正樹, 徳光浩, 金山直樹
- Organizer
  第68回日本生物工学会大会
- Place of Presentation
  富山国際会議場（富山県富山市）
- Year and Date
  2016-09-29
- Data Source
  KAKENHI-PROJECT-15H04196
[Presentation] 抗体遺伝子変異における転写依存性過程におけるSRSF1-3の役割の解析2016
- Author(s)
  川口祐加、横山和輝、河本奈緒子、成木弘明、松山雄磨、金廣優一、曲正樹、大森斉、徳光浩、金山直樹
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-12-02
- Data Source
  KAKENHI-PROJECT-15H04196
[Presentation] Ca2+/Calmodulin-dependent Protein Kinase Kinaseシグナル伝達機構の茶道原理の解明（基質認識機構）2016
- Author(s)
  藤原侑哉、川口義典、藤本智仁、金山直樹、曲正樹、徳光浩
- Organizer
  第３９回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-26440056
[Presentation] AID発現とSHM誘導におけるBCRシグナルの役割2016
- Author(s)
  梶浦　雄也、金廣　優一、有年　由貴子、曲　正樹、徳光　浩、金山　直樹
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-12-02
- Data Source
  KAKENHI-PROJECT-15H04196
[Presentation] Calmodulin Signal Networkのインターラクトーム解析2015
- Author(s)
  徳光　浩
- Organizer
  第38回日本分子生物学会年会第88回日本生化学会大会　合同大会
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2015-12-01
- Invited
- Data Source
  KAKENHI-PROJECT-26440056
[Presentation] COMPREHENSIVE IDENTIFICATION OF HUMAN CALMODULIN-TARGETS2015
- Author(s)
  Furuya Y, Denda M, Kanayama N, Magari M, Morishita R, Tokumitsu H
- Organizer
  19th International Symposium on Calcium Binding Proteins and Calcium Function In Health and Disease
- Place of Presentation
  ナッシュビル・アメリカ
- Year and Date
  2015-05-30
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26440056
[Presentation] Ca2+/Calmodulin結合型転写因子の網羅的同定2015
- Author(s)
  太尾田　泰成、大西　和貴、古谷　雄穂、傳田　美和子、金山　直樹、曲　正樹、森下　了、徳光　浩
- Organizer
  第38回日本分子生物学会年会第88回日本生化学会大会　合同大会
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-26440056
[Presentation] ANALYSIS OF DISTINCT ROLES OF CAMKK ISOFORMS USING STO-609- RESISTANT MUTANTS IN LIVING CELLS2015
- Author(s)
  Fujiwara Y, Hiraoka Y, Fujimoto T, Kanayama N, Magari M, Tokumitsu H
- Organizer
  19th International Symposium on Calcium Binding Proteins and Calcium Function In Health and Disease
- Place of Presentation
  ナッシュビル・アメリカ
- Year and Date
  2015-05-30
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26440056
[Presentation] ニワトリSRSF1-3の抗体遺伝子変異における機能部位の探索2015
- Author(s)
  155成木弘明, 川口祐加, 宮崎誠士, 河本奈緒子, 横山和輝, 徳光浩, 曲正樹, 金山直樹
- Organizer
  BMB2015
- Place of Presentation
  神戸国際会議場･展示場
- Year and Date
  2015-12-02
- Data Source
  KAKENHI-PROJECT-15H04196
[Presentation] ニワトリB細胞株DT40におけるヒト型抗体の産生増強2015
- Author(s)
  中谷耕治, 檀上悟史, 曲正樹, 徳光浩, 金山直樹
- Organizer
  第67回日本生物工学会大会
- Place of Presentation
  鹿児島市
- Year and Date
  2015-10-27
- Data Source
  KAKENHI-PROJECT-15H04196
[Presentation] CaMKKβによる選択的AMPK活性化の細胞生物学的および生化学的解析2015
- Author(s)
  藤原　侑哉、川口　義典、藤本　智仁、曲　正樹、金山　直樹、徳光　浩
- Organizer
  第38回日本分子生物学会年会第88回日本生化学会大会　合同大会
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-26440056
[Presentation] ニワトリ B 細胞株における BCR シグナル依存性アポトーシスの制御による高親和性抗体の作製2015
- Author(s)
  金山直樹, 古賀舞, 池田美香, 小嶋宏侑, 曲正樹, 徳光浩, 大森斉
- Organizer
  第67回日本生物工学会大会
- Place of Presentation
  鹿児島市
- Year and Date
  2015-10-27
- Data Source
  KAKENHI-PROJECT-15H04196
[Presentation] ヒトCalmodulin標的分子の網羅的同定2014
- Author(s)
  古谷　雄穂, 西口　みゆ, 傳田美和子, 曲正樹，金山直樹，森下　了, 徳光浩
- Organizer
  第８７回日本生化学会大会
- Place of Presentation
  京都
- Year and Date
  2014-10-18
- Data Source
  KAKENHI-PROJECT-26440056
[Presentation] カルモデュリン標的分子の網羅解析から見たカルシウムシグナル伝達の多様性2014
- Author(s)
  徳光　浩
- Organizer
  日本薬学会関東支部会
- Place of Presentation
  東京
- Year and Date
  2014-10-04
- Invited
- Data Source
  KAKENHI-PROJECT-26440056
[Presentation] STO-609抵抗性変異体を用いたCaMKKシグナル伝達の機能解析2014
- Author(s)
  藤原　侑哉, 平岡　佑理, 曲正樹，金山直樹，徳光浩
- Organizer
  第８７回日本生化学会大会
- Place of Presentation
  京都
- Year and Date
  2014-10-17
- Data Source
  KAKENHI-PROJECT-26440056
[Presentation] Identification of a novel target for Ca^<2+>/ CaM-dependent protein kinase kinase by using an ATP analogue2011
- Author(s)
  藤本智仁, 波多野直哉, 野崎直仁, 横倉(揺本)沙紀, 小林良二, 徳光浩
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  京都
- Year and Date
  2011-09-23
- Data Source
  KAKENHI-PROJECT-21570143
[Presentation] Regulatory Mechanism of CaMKK by Autophosphorylation2011
- Author(s)
  徳光浩、横倉(揺本)沙紀、波多野直哉、藤本智仁、小林良二
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  京都
- Year and Date
  2011-09-23
- Data Source
  KAKENHI-PROJECT-21570143
[Presentation] PRG-1(plasticity related gene 1), a novel neuronal calmodulin-binding protein2010
- Author(s)
  徳光浩、波多野直哉、土屋光正、横倉(揺本)沙紀、藤本智仁、小原直樹、小林良二、阪上洋行
- Organizer
  第33回日本分子生物学会年会・第83回日本生化学会大会,合同大会
- Place of Presentation
  神戸
- Year and Date
  2010-12-09
- Data Source
  KAKENHI-PROJECT-21570143
[Presentation] PRG-1 (plasticity related gene 1), a novel neuronal calmodulin-binding protein2010
- Author(s)
  Tokumitsu, et al.
- Organizer
  第33回日本分子生物学会年会・第83回日本生化学会大会
- Place of Presentation
  神戸ポートアイランド(兵庫県)
- Year and Date
  2010-12-09
- Data Source
  KAKENHI-PROJECT-21570143
[Presentation] Ca^<2+>/ calmodulin-dependent protein kinae kinase ca utilize GTP as a phosphate donor2010
- Author(s)
  藤本智仁、小林良二、徳光浩
- Organizer
  第33回日本分子生物学会年会・第83回日本生化学会大会,合同大会
- Place of Presentation
  神戸
- Year and Date
  2010-12-10
- Data Source
  KAKENHI-PROJECT-21570143

1. KOBAYASHI Ryoji (00020917)

# of Collaborated Projects: 10 results

# of Collaborated Products: 21 results
2. MURAO Koji (20291982)

# of Collaborated Projects: 6 results

# of Collaborated Products: 4 results
3. HATANO Naoya (10332280)

# of Collaborated Projects: 4 results

# of Collaborated Products: 11 results
4. ISHIDA Toshihiko (50159737)

# of Collaborated Projects: 4 results

# of Collaborated Products: 4 results
5. 曲正樹 (50359882)

# of Collaborated Projects: 4 results

# of Collaborated Products: 49 results
6. HIDAKA Hiroyoshi (80100171)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
7. WATANABE Masato (30220924)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
8. IMACHI Hitomi (80380187)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
9. TOKUDA masaki (10163974)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. HAGIWARA Masatoshi (10208423)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
11. OKABE akinobu (20093677)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
12. MIYATA shigeru (90314913)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
13. MATSUSHITA osamu (00209537)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
14. OHNISHI Hiroaki (90223891)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
15. Suizu Futoshi (90431379)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
16. OHMORI Koji (00263913)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. TAMAI Eiji (40333512)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. YOSHITAKA Sayo (20343311)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. Kanayama Naoki (70304334)

# of Collaborated Projects: 1 results

# of Collaborated Products: 23 results
20. 平田徳幸 (40595956)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 松岡達臣 (90209510)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 石川彰彦 (10263617)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
23. 渡辺泰男 (10273228)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 江藤真澄 (20232960)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
25. 山川けいこ (20855704)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. 十亀陽一郎 (60769850)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. HARTSHORNE David J.

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. KIMURA Yoshishige

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. SAJI Ikutaro

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
30. UENO Masaki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
31. 千葉陽一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
32. 松井利康

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Tokumitsu Hiroshi 徳光 浩

TOKUMITSU Hiorshi 徳光 浩

TOKUMITSU Hiroshi 徳光 浩

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新たなカルモデュリン制御リン酸化・脱リン酸化酵素の発見とシグナル伝達解析Principal Investigator

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Development of inhibitors based on CaMKK-mediated signal transductionPrincipal Investigator

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Regulation of CaMKKbeta/AMPK signaling and drug developmentPrincipal Investigator

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Phosphorylation-dependent regulatory mechanism of calmoudlin-kinase cascadePrincipal Investigator

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Comprehensive identification and signal transduction analysis of calmodulin-targets by functional proteomicsPrincipal Investigator

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Identification and characterization of a novel target for CaM-kinase cascadePrincipal Investigator

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Analysis of calmodulin-kinase cascade by using functional proteomics.Principal Investigator

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Tokumitsu Hiroshi 徳光浩

TOKUMITSU Hiorshi 徳光浩

TOKUMITSU Hiroshi 徳光浩