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Nakao Hiroshi  中尾 浩史

ORCIDConnect your ORCID iD *help
… Alternative Names

NAKAO Hiroshi  中尾 浩史

中尾 浩史  ナカオ ヒロシ

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Researcher Number 20237217
Other IDs
Affiliation (Current) 2025: 琉球大学, 医学部, 教授
Affiliation (based on the past Project Information) *help 2011 – 2017: 琉球大学, 医学部, 教授
2007 – 2010: Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Associate Professor
2007: 岡山大学, 大学院・歯薬学総合研究科, 准教授
2005 – 2006: Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Associate Professor, 大学院・医歯薬学総合研究科, 助教授
2002 – 2004: 岡山大学, 薬学部, 助教授 … More
2001: 国立小児病院, (小児医療研究センター)・感染症研究部, 研究員
1994: 国立小児病院, 小児医療研究センター・感染症研究部・細菌研究質, 研究員
1993: 国立小児病院, 小児医療研究センター感染症研究部, 研究員 Less
Review Section/Research Field
Principal Investigator
Bacteriology (including Mycology) / Bacteriology (including Mycology)
Except Principal Investigator
Bacteriology (including Mycology)
Keywords
Principal Investigator
siderophore / 鉄 / Vibrio vulnificus / シデロフォア / 腸炎ビブリオ / transcriptional regulation / iron / 転写調節 / ビブリオブニフィカス / 転写制御 … More / 賜炎ビブリオ / 細菌 / 感染症 / 受容体 / モノクローナル抗体 / 病原性 / σ因子 / 遺伝子の多様性 / 志賀毒素 / 腸管出血性大腸菌 … More
Except Principal Investigator
アエロモナス / 大腸菌 / Enterotoxin / Escherichia coli / Protease / Aeromonas / 溶血毒素 / プロテアーゼ / エンテロトキシン / 腸管感染症 / 下痢 / 細菌 / Hemolvsin / Maturation pathway / Bacterial toxin / Enteric infection / カルボキシ末端 / メタロプロテアーゼ / セリンプロテアーゼ / 下痢毒素 / 成熟化過程 / 細菌毒素 / Pathogenicity / Secretion apparatus / Chaperone / Bacteria / 外膜蛋白質 / 成熟化 / タンパク毒素 / 基質 / フーリン / 溶血毒 / 病原性 / 分泌装置 / シャペロン / コロニーハイブリダイゼーション / 毒素原性大腸菌 / 腸管病原性大腸菌 / 病原因子 / 抗生物質 / コレラ / 薬剤感受性 / 国際研究者交流 / 薬剤耐性 / ミャンマー / 下痢症 / 腸管感染菌 Less
  • Research Projects

    (9 results)
  • Research Products

    (36 results)
  • Co-Researchers

    (6 People)
  •  Receptor of vibrioferrin, siderophore of Vibrio parahaemolyticusPrincipal Investigator

    • Principal Investigator
      Nakao Hiroshi
    • Project Period (FY)
      2012 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Bacteriology (including Mycology)
    • Research Institution
      University of the Ryukyus
  •  Analysis of iron-acquire receptor protein of Vibrio parahaemolyticus and development of specific growth inhibitorPrincipal Investigator

    • Principal Investigator
      NAKAO Hiroshi
    • Project Period (FY)
      2008 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Bacteriology (including Mycology)
    • Research Institution
      University of the Ryukyus
      Okayama University
  •  Survey of contamination of enteropathogenic bacteria in Myanmar

    • Principal Investigator
      OKAMOTO Keinosuke
    • Project Period (FY)
      2006 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Bacteriology (including Mycology)
    • Research Institution
      Okayama University
  •  Analysis of Maturation pathway protein toxin of Enteric Bacteria and Studies of Prevention of Diarrhea

    • Principal Investigator
      OKAMOTO Keinosuke
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Bacteriology (including Mycology)
    • Research Institution
      Okayama University
  •  Analysis of secretion and maturation pathway of bacterial proteintoxin and its application to clinical study

    • Principal Investigator
      OKAMOTO Keinosuke
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Bacteriology (including Mycology)
    • Research Institution
      OKAYAMA UNIVERSITY
  •  Identification and characterization of iron-regulated genes required for utilization of a erobactin in Vibrio vulnificusPrincipal Investigator

    • Principal Investigator
      NAKAO Hiroshi
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Bacteriology (including Mycology)
    • Research Institution
      OKAYAMA UNIVERSITY
  •  腸管出血性大腸菌の持つ様々な病原因子遺伝子の多様性に関する研究Principal Investigator

    • Principal Investigator
      中尾 浩史
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Bacteriology (including Mycology)
    • Research Institution
      Okayama University
      National Research Institute for Child Health and Development
  •  腸炎エルシニアST遺伝子発現を正に調節する領域のクローニングと機能の解析Principal Investigator

    • Principal Investigator
      中尾 浩史
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Bacteriology (including Mycology)
    • Research Institution
      National Research Institute for Child Health and Development
  •  yersinia enterocolitica の産生するST遺伝子の研究Principal Investigator

    • Principal Investigator
      中尾 浩史
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Bacteriology (including Mycology)
    • Research Institution
      National Research Institute for Child Health and Development

All 2013 2012 2011 2010 2009 2008 2004 2003

All Journal Article Presentation

  • [Journal Article] The Vibrio parahaemolyticus small RNA ryhB promotes production of the siderophore vibrioferrin by stabilizing the polycistronic mRNA.2013

    • Author(s)
      Tanabe, T., Funahashi, T., Nakao, H., Maki, J., Yamamoto, S.
    • Journal Title

      J. Bacteriol.

      Volume: 195 Issue: 16 Pages: 3692-3703

    • DOI

      10.1128/jb.00162-13

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24590529, KAKENHI-PROJECT-25870987
  • [Journal Article] Characterization of Vibrio parahaemolyticus genes encoding the systems for utilization of enterobactin as a xenosiderophore.2012

    • Author(s)
      Hiroshi Tsujibo
    • Journal Title

      Microbiology

      Volume: 158 Issue: 8 Pages: 2039-2049

    • DOI

      10.1099/mic.0.059568-0

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22580381, KAKENHI-PROJECT-22790140, KAKENHI-PROJECT-23790166, KAKENHI-PROJECT-24580309, KAKENHI-PROJECT-24590529
  • [Journal Article] Inactivation of Vibrio vulnificus hemolysin through mutation of the N-or C-terminus of the lectin-like domain2011

    • Author(s)
      Miyoshi, S., Abe, Y., Senoh, M., Mizuno, T., Maehara, Y., and Nakao, H.
    • Journal Title

      Toxicon

      Volume: 57(6) Pages: 904-908

    • NAID

      120004247121

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590444
  • [Journal Article] Inactivation of Vibrio vulnificus hemolysin through mutation of the N- or C-terminus of the lectin-like domain.2011

    • Author(s)
      Miyoshi, S., Abe, Y., Senoh, M., Mizuno, T., Maehara, Y., Nakao, H.
    • Journal Title

      Toxicon 57(6)

      Pages: 904-908

    • NAID

      120004247121

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590444
  • [Journal Article] The Vibrio parahaemolyticus pvuAl gene(formerly termed psuA) encodes a second ferric vibrioferrin receptor that requires tonB22011

    • Author(s)
      Tanabe, T., Funahashi, T., Okajima, N., Nakao, H., Takeuchi, Y., Miyamoto, K., Tsujibo, H., and Yamamoto, S.
    • Journal Title

      FEMS Microbiol. Lett

      Volume: 324(1) Pages: 73-79

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590444
  • [Journal Article] Assimilation of metal ions bound to porphyrins or phrphyrin-peptides by Vibrio vulnificus2010

    • Author(s)
      Miyoshi, S., Sasaki, T., Kaku, N., Inoue, T., Uozumi, N., Maehara, Y., and Nakao, H.
    • Journal Title

      Biocontrol Sci.

      Volume: 15 Pages: 1-6

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590444
  • [Journal Article] Assimilation of metal ions bound to porphyrins or phrphyrin-peptides by Vibrio vulnificus.2010

    • Author(s)
      Miyoshi, S., Sasaki, T., Kaku, N., Inoue, T., Uozumi, N., Maehara, Y., Nakao, H.
    • Journal Title

      Biocontrol Sci. 15

      Pages: 1-6

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590444
  • [Journal Article] Identification and Characterization of Genes Required for Utilization of Desferri-Ferrichrome and Aerobactin in Vibrio parahaemolyticus. Biological & Pharmaceutical Bulletin 322009

    • Author(s)
      Funahashi, T., Tanabe, T., Shiuchi, K., Nakao, H. and Yamamoto, S.
    • Journal Title

      Biol. Pharm. Bull

      Volume: 32(3) Pages: 359-365

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590444
  • [Journal Article] Identification and Characterization of Genes Required for Utilization of Desferri-Ferrichrome and Aerobactin in Vibrio parahaemolyticus.2009

    • Author(s)
      Funahashi, T., Tanabe, T., Shiuchi, K., Nakao, H., Yamamoto, S.
    • Journal Title

      Biological & Pharmaceutical Bulletin 32, Biol.Pharm.Bull. 32(3)

      Pages: 359-365

    • NAID

      110007122740

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590444
  • [Journal Article] Modulation of Vibrio mimicus hemolysin through limited proteolysis by an endogenous metalloprotease2009

    • Author(s)
      Mizuno, T., Sultan, S. Z., Kaneko, Y., Yoshimura, T., Maehara, Y., Nakao, H., Tsuchiya, T., Shinoda, S., Miyoshi, S.
    • Journal Title

      FEBS Journal

      Volume: 276 Pages: 825-834

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590444
  • [Journal Article] Modulation of Vibrio mimicus hemolysin through limited proteolysis by an endogenous metalloprotease.2009

    • Author(s)
      Mizuno, T., Sultan, S.Z., Kaneko, Y., Yoshimura, T., Maehara, Y., Nakao, H., Tsuchiya, T., Shinoda, S., Miyoshi, S.
    • Journal Title

      FEBS Journal 276

      Pages: 825-834

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590444
  • [Journal Article] Identification and transcriptional organization of a gene cluster involved in biosynthesis and trasport of acinetobactin, a siderophore produced by Acinetebacter baumannii ATCC19606T.2004

    • Author(s)
      Mihara K., Tanabe T., Yamakawa Y., Funahashi T., Nakao H., Narimatsu S., Yamamoto S.
    • Journal Title

      Microbiology-SGM 158

      Pages: 2587-2597

    • Data Source
      KAKENHI-PROJECT-15590386
  • [Journal Article] Identification and characterization of two contiguous operons required for aerobactin transport and biosynthesis in Vibrio mimicus.2004

    • Author(s)
      Moon, Y.-H., Tanabe, T., Funahashi, T., Shiuchi, K., Nakao, H., Yamamoto, S.
    • Journal Title

      Microbiol. Immunol. 48

      Pages: 389-398

    • NAID

      10012919607

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15590386
  • [Journal Article] Identification and characterization of two contiguous operons required for aerobactin transport and biosynthesis in Vibrio mimicus.2004

    • Author(s)
      Moon, Y.-H., Tanabe, T., Funahashi, T., Shiuchi, K., Nakao, H., Yamamoto
    • Journal Title

      Microbiol.Immunol. 48

      Pages: 389-398

    • NAID

      10012919607

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590386
  • [Journal Article] Identification and transcriptional organization of a gene cluster involved in biosynthesis and trasport of acinetobactin, a siderophore produced by Acinetobacter baumannii ATCC19606T.2004

    • Author(s)
      Mihara K., Tanabe T., Yamakawa Y., Funahashi T., Nakao H., Narimatsu S., Yamamoto S.
    • Journal Title

      Microbiology-SGM 150

      Pages: 2587-2597

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15590386
  • [Journal Article] Identification and characterization of two contiguous operons required for aerobactin transport and biosynthesis in Vibrio mimicus.2004

    • Author(s)
      Moon, Y.-H., Tanabe, T., Funahashi, T., Shiuchi, K., Nakao, H., Yamamoto, S.
    • Journal Title

      Microbiol.Immunol. 48

      Pages: 389-398

    • NAID

      10012919607

    • Data Source
      KAKENHI-PROJECT-15590386
  • [Journal Article] Identification of genes required for biosynthesis and uansport of the siderophore Vibrioferrin in Vibrio parahaemolyticus.2003

    • Author(s)
      Tanabe, T., Funahashi, T., Nakao, H., Miyoshi, S., Shinoda, S., Yamamoto, S.
    • Journal Title

      J.Bacteriol. 185

      Pages: 6938-6949

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590386
  • [Journal Article] An iron-regulated gene required for utilization of aerobactin as an exogenous siderophore in Vibrio parahaemolyticus.2003

    • Author(s)
      Funahashi, T., Tanabe, T., Aso, H., Nakao, H., Fujii, Y., Okamoto, K., Narimatsu, S., Yamamoto, S.
    • Journal Title

      Microbiology 149

      Pages: 1217-1225

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15590386
  • [Journal Article] Identification of genes required for biosynthesis and transport of the siderophore Vibrioferrin in Vibrio parahaemolyticus.2003

    • Author(s)
      Tanabe, T., Funahashi, T., Nakao, H., Miyoshi, S., Shinoda, S., Yamamoto, S.
    • Journal Title

      J.Bacteriol. 185

      Pages: 6938-6949

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15590386
  • [Presentation] 腸炎ビブリオの鉄獲得系と生体内増殖能の検討2012

    • Author(s)
      中尾浩史、高橋栄造、田邊知孝、三好伸一、岡本敬の介、山本重雄
    • Organizer
      及び抗ビブリオフェリン受容体モノクローナル抗体の作成第85回日本細菌学会総会
    • Place of Presentation
      長崎
    • Data Source
      KAKENHI-PROJECT-20590444
  • [Presentation] 腸炎ビブリオの鉄獲得系と生体内増殖能の検討、及び抗ビブリオフェリ・ン受容体モノクローナル抗体の作成Vibrioferrin is associated with growth of Vibrio parahaemolyticus in vivo2012

    • Author(s)
      中尾浩史, 他
    • Organizer
      第85回日本細菌学会総会(長崎)
    • Place of Presentation
      長崎ブリックホール
    • Year and Date
      2012-03-29
    • Data Source
      KAKENHI-PROJECT-20590444
  • [Presentation] Vibrio mimicusヘモリジンの成熟化に関与する菌体外プロテアーゼ2010

    • Author(s)
      水野環、前原陽子、中尾浩史、三好伸一
    • Organizer
      第57回毒素シンポジウム
    • Place of Presentation
      愛知・長浜
    • Data Source
      KAKENHI-PROJECT-20590444
  • [Presentation] ヒト抗菌ペプチドのビブリオ属細菌に対する影響ヒト抗菌ペプチドのビブリオ属細菌に対する影響2010

    • Author(s)
      池原寛人, 前原陽子, 中尾浩史, 三好伸一
    • Organizer
      第63回日本細菌学会中国・四国支部総会
    • Place of Presentation
      愛媛・松山
    • Data Source
      KAKENHI-PROJECT-20590444
  • [Presentation] 腸炎ビブリオのvibrioferrinを介する鉄獲得系と病原性2010

    • Author(s)
      山科竜一、山田真人、田邊知孝、高橋栄造、山本重雄、岡本敬の介、三好伸一、中尾浩史
    • Organizer
      第63回日本細菌学会中国・四国支部総会
    • Place of Presentation
      愛媛・松山
    • Data Source
      KAKENHI-PROJECT-20590444
  • [Presentation] 腸炎ビブリオの産生するシデロフォア, vibrioferrinと病原性2009

    • Author(s)
      山田真人、高橋栄造、岡本敬の介、田邊知孝、山本重雄、中尾浩史
    • Organizer
      第129回日本薬学会年会
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-20590444
  • [Presentation] ビブリオ・バルニフィカスの金属プロテアーゼ遺伝子に関する研究2009

    • Author(s)
      加藤景三、王継有、前原陽子、中尾浩史、三好伸一
    • Organizer
      第48回日本薬学会中国四国支部学術大会
    • Place of Presentation
      徳島
    • Data Source
      KAKENHI-PROJECT-20590444
  • [Presentation] 腸炎ビブリオにおける外因性シデロフォアferrichrome及びaerobactin輸送系の解析2009

    • Author(s)
      舟橋達也、田邊知孝、氏内圭一、中尾浩史、山本重雄
    • Organizer
      第129回日本薬学会年会
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-20590444
  • [Presentation] 腸炎ビブリオの産生するシデロフォア, vibrioferrin と病原性2009

    • Author(s)
      山田真人, 高橋栄造, 岡本敬の介, 田邊知孝, 山本重雄, 中尾浩史
    • Organizer
      日本薬学会第129年会
    • Place of Presentation
      京都
    • Year and Date
      2009-03-27
    • Data Source
      KAKENHI-PROJECT-18406014
  • [Presentation] Vibrio mimicusの産生する毒素活性化作用を有する新規プロテアーゼ2009

    • Author(s)
      水野環、前原陽子、中尾浩史、土屋友房、三好伸一
    • Organizer
      第82回日本細菌学会総会
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PROJECT-20590444
  • [Presentation] ビブリオ・バルニフィカス金属プロテアーゼの無細胞系での合成2009

    • Author(s)
      三浦迫、前原陽子、中尾浩史、三好伸一
    • Organizer
      第48回日本薬学会中国四国支部学術大会
    • Place of Presentation
      徳島
    • Data Source
      KAKENHI-PROJECT-20590444
  • [Presentation] Vibrio mimicus金属プロテアーゼの発現制御2009

    • Author(s)
      李涛、前原陽子、中尾浩史、土屋友房、三好伸一
    • Organizer
      第129回日本薬学会年会
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-20590444
  • [Presentation] 腸炎ビブリオのシデロフォア, vibrioferrinを介する鉄獲得系と病原性2009

    • Author(s)
      山田真人、田邊知孝、高橋栄造、山本重雄、岡本敬の介、三好伸一、中尾浩史
    • Organizer
      第48回日本薬学会中国四国支部学術大会
    • Place of Presentation
      徳島
    • Data Source
      KAKENHI-PROJECT-20590444
  • [Presentation] 腸炎ビブリオのvibrioferrinを介する鉄獲得系の分子遺伝学的研究2009

    • Author(s)
      田邊知孝、舟橋達也、中尾浩史、山本重雄
    • Organizer
      第129回日本薬学会年会
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-20590444
  • [Presentation] Vibrio vulnificus NCIMB 2137株の分泌するセリンプロテアーゼの精製と性状の解析2008

    • Author(s)
      王継有、前原陽子、中尾浩史、土屋友房、三好伸一
    • Organizer
      第47回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
    • Place of Presentation
      岡山
    • Data Source
      KAKENHI-PROJECT-20590444
  • [Presentation] Vobrio vulnificus溶血毒素の活性発現におけるC末端アミノ酸残基の効果2008

    • Author(s)
      阿部祐樹, 妹尾充敏, 中尾浩史, 三好伸一
    • Organizer
      第47回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
    • Place of Presentation
      岡山
    • Data Source
      KAKENHI-PROJECT-20590444
  • [Presentation] Vibrio mimicusのトランスポゾン変異株の単離と解析2008

    • Author(s)
      李涛、前原陽子、中尾浩史、土屋友房、三好伸一
    • Organizer
      第47回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
    • Place of Presentation
      岡山
    • Data Source
      KAKENHI-PROJECT-20590444
  • 1.  OKAMOTO Keinosuke (70131183)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 1 results
  • 2.  MIYOSHI Shin-ichi (60182060)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 3.  TAKAHASHI Eizo (70379733)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 1 results
  • 4.  YAMANAKA Hiroyasu (30202386)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 5.  YAMAMOTO Shigeo (40033229)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 8 results
  • 6.  TSUJIBO Hiroshi
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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