Nishii Kiyomasa 西井清雅

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NISHII Kiyomasa 西井清雅

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Researcher Number	20264020
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Affiliation (Current)	2025: 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究施設、病院並びに防衛, 解剖学, 教授
Affiliation (based on the past Project Information) *help	2013: 東京大学, 大学院医学系研究科, 助教 2013: 防衛医科大学校, 医学部, 助教 2012: 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究, 医学教育部医学科専門課程, 助教 2012: 防衛医科大学校, 医学教育部医学科専門課程, 助教 2010 – 2011: 防衛医科大学校, 医学教育部・医学科専門課程, 助教 … More 2009: 東大, 医学(系)研究科(研究院), 助教 2008: The University of Tokyo, 大学院・医学系研究科, 助教 2006: Tokyo Medical and Dental University, Assistant Professor(COE), 大学院医歯学総合研究科, COE拠点形成特別研究員 2005: 東京医科歯科大学, 大学院・医歯学総合研究科, COE拠点形成特任教員 2005: 東京医科歯科大学, 大学院・医歯学総合研究科, COE拠点形成特別研究員 2000 – 2004: Faculty of Medical Sciences KYUSHU UNIVERSITY, Reserch Associate, 大学院・医学研究院, 助手 1999: 九州大学, 大学院・医学系研究科, 助手 1995 – 1998: 九州大学, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator General anatomy (including Histology/Embryology) / General anatomy (including Histology/Embryology) Except Principal Investigator General anatomy (including Histology/Embryology) / General anatomy (including Histology/Embryology) / Circulatory organs internal medicine / Nerve anatomy/Neuropathology
Keywords	Principal Investigator MDCK cell / freeze-fracture / RT-PCR / blood-brain barrier / ZO-1 / claudin / tight junction / 心臓 / gene targeting / gap junction … More / connexin / コネキシン / ギャップ結合 / MDCK cells / freeze fracture / clauclin / 画像解析 / 細胞・組織 / 発生・分化 / 組織形成 / 細胞分化 / 可塑性 / Rcc1 / 核-細胞質問輸送 / ノックアウトマウス / Nfatcl / Cx43 / cTnT / Cx45 / heart / lacZ / Cre-loxP system / DADI / RanBP2 / アポトーシス / 細胞周期 / 核膜孔 … More Except Principal Investigator gap junction / connexin / gene targeting / heart / コネキシン / Cx45 / ギャップ結合 / endocardial cushion / Cx43 / confocal laser scanning microscopy / central nervous system / knockout mice / lacZ / GFP / Cx37 / Cx40 / コネキシン45 / RT-PCR / epididymis / freeze fracture / MDCK cell / actin / ZO-1 / claudin / tight junction / cardiac development / Nfatcl / knockout mouse / loxP / Cre / 心臓 / LacZ / electron microscopy / smooth muscle / connexin45 / A-V block / NFATC1 / コネキシン43 / ノックアウトマウス / コネキシン40 / 刺激伝導系 / atrioventricular block / NFATc1 / 心内膜床 / 心発生 / permeability / MDCK / cushion defect / shaer stress / cardiac valve / 心内膜床欠損 / heart development / ELECTRON MICROSCOPY / IMMUNOCYTOCHEMISTRY / STEM CELL / LACZ / KNOCKOUT MOUSE / GAP JUNCTION / CONNEXIN45 / lac Z / immunocytochemistry / stem cell / floxed : Cx mice / embryonic cardiac myocyte / Cx 45 / gap Junction / loxp / gene trageting / connexin 45 / confocal laser scannning microscopy / intestinal motility / NF-ATcl / Cre-loxP system / intestinal pacemaker / phosphorylation / 卵胞 / エナメル形成 / 小腸 / 血管内皮 / 小腸ペースメーカー / 小腸ペースメーカ / リン酸化 / パリティ保障機構 / 伝導障害 / パリティ保証機構 / 洞結節 / ギャップジャンクション / PSD / ＰＳＤ / 高解像度 / ＧＦＰ / イメージング / シナプス / シナプス可塑性 / 二光子顕微鏡 / 超解像顕微鏡 / シナプス後肥厚部 / 分子神経生物学 / Fas / p53 / oligosaccharyltransferase / N-glycosylation / embryonic lethality / Dad1 / apoptosis / 内皮細胞 / 心筋 / ヒス束 / プルキン工線維 / 房室結節 / 洞房結節 Less

Parity check by gap junctions maintains normal cardiac conduction in sinoatrial node
- Principal Investigator
  
  NISHII Akiko
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Tokyo Women's Medical University
Biometric analysis of organogenesisPrincipal Investigator
- Principal Investigator
  
  NISHII Kiyomasa
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General anatomy (including Histology/Embryology)
- Research Institution
  National Defense Medical College
Molecular Anatomy of Synaptic Structure
- Principal Investigator
  
  OKABE Shigeo
- Project Period (FY)
  2009 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  The University of Tokyo
核-細胞質間輸送の制御下にあるシナプス可塑性形成機構の可視化Principal Investigator
- Principal Investigator
  
  西井清雅
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General anatomy (including Histology/Embryology)
- Research Institution
  The University of Tokyo
Molecular anatomical research for the role of gap junction proteins in cardiac function.
- Principal Investigator
  
  SHIBATA Yosaburo
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General anatomy (including Histology/Embryology)
- Research Institution
  KYUSHU UNIVERSITY
初期心拍動に異常を示す遺伝子変異マウスの解析Principal Investigator
- Principal Investigator
  
  西井清雅
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General anatomy (including Histology/Embryology)
- Research Institution
  Tokyo Medical and Dental University
  Kyushu University
Morphological and functional analysis of tight junction by overexpression or suppression of tight junction plaque protein ZO-1
- Principal Investigator
  
  INAI Tetsuichiro
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General anatomy (including Histology/Embryology)
- Research Institution
  KYUSHU UNIVERSITY
Molecular Anatomy of Functional Differentination Affected by Combination of Gap Junctions, Connexins
- Principal Investigator
  
  SHIBATA Yosaburo
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General anatomy (including Histology/Embryology)
- Research Institution
  KYUSHU UNIVERSITY
A STUDY OF CELLULAR NETWORKS WITHIN THE CENTRAL NERVOUS SYSTEM BY USING CONNEXIN45 GENE KNOCKOUT-LACZ GENE KNOCKIN MICE.
- Principal Investigator
  
  NAKAMURA Kei-ichiro
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General anatomy (including Histology/Embryology)
- Research Institution
  KURUME UNIVERSITY
  Kyushu University
Molecular Anatomy of Gap Junction Expression Regulation Effect in Conditional Cx Knockout Mice
- Principal Investigator
  
  SHIBATA Yosaburo
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General anatomy (including Histology/Embryology)
- Research Institution
  Kyushu University
Diversity of tight junction protein, claudin, in mouse tissues and significance of binding between claudin and ZO-1Principal Investigator
- Principal Investigator
  
  NISHII Kiyomasa, 稲井哲一朗
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General anatomy (including Histology/Embryology)
- Research Institution
  Kyushu University
心筋に発現するギャップ結合コネキシン蛋白の条件下欠損マウスの作製と、その解析Principal Investigator
- Principal Investigator
  
  西井清雅
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  General anatomy (including Histology/Embryology)
- Research Institution
  Kyushu University
An morphological analysis of the intestinal pacemaker cells by connexin45 knock-out mice
- Principal Investigator
  
  NAKAMURA Kei-ichiro
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General anatomy (including Histology/Embryology)
- Research Institution
  KYUSHU UNIVERSITY
オリゴ糖付加酵素複合体の構成要素DAD1を欠損するマウスの解析
- Principal Investigator
  
  柴田洋三郎
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Kyushu University
ギャップ結合蛋白遺伝子変異マウスの分子解剖学的研究
- Principal Investigator
  
  SHIBATA Yosaburo
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  General anatomy (including Histology/Embryology)
- Research Institution
  KYUSHU UNIVERSITY
ノックインベクターによるコネキシン欠損マウスの作製と、その発現調節の解析Principal Investigator
- Principal Investigator
  
  西井清雅
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  General anatomy (including Histology/Embryology)
- Research Institution
  Kyushu University
心筋細胞間の機能結合形成にいたる分子機構の発現過程にかんする研究
- Principal Investigator
  
  柴田洋三郎
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyushu University
心筋細胞間の機能結合形成にいたる分子機構の発現過程にかんする研究
- Principal Investigator
  
  SHIBATA Yosaburo
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyushu University
ギャップ結合蛋白質コネキシン細胞分化への関与についての検討Principal Investigator
- Principal Investigator
  
  西井清雅
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  General anatomy (including Histology/Embryology)
- Research Institution
  Kyushu University
Molecular anatomy of functional structural expression of gap junctions.
- Principal Investigator
  
  SHIBATA Yosaburo
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  General anatomy (including Histology/Embryology)
- Research Institution
  Kyushu University

All 2014 2013 2012 2011 2010 2008 2006 2004 2003

All Journal Article Presentation

[Journal Article] Targeted disruption of the cardiac troponin T gene causes sarcomere disassembly and defects in heartbeat within the early mouse embryo.2008
- Author(s)
  K. Nishii et al.
- Journal Title
  
  Dev. Biol. 322
  
  Pages: 65-73
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590184
[Journal Article] Mode and determination of the initial contraction stage in the mouse embryo heart.2006
- Author(s)
  K.Nishii, Y.Shibata
- Journal Title
  
  Anat.Embryol. (in press)
- Data Source
  KAKENHI-PROJECT-16790126
[Journal Article] Mode and determination of the initial contraction stage in the mouse embryo heart.2006
- Author(s)
  K.Nishii et al.
- Journal Title
  
  Anat.Embry. 211(2)
  
  Pages: 95-100
- Data Source
  KAKENHI-PROJECT-17390052
[Journal Article] Mode and determination of the initial contraction stage in the mouse embryo heart2006
- Author(s)
  K.Nishii, Y.Shibata
- Journal Title
  
  Anat.Embry. 211(2)
  
  Pages: 95-100
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390052
[Journal Article] Mode and determination of the initial contraction stage in the mouse embryo heart.2006
- Author(s)
  K.Nishii, Y.Shibata
- Journal Title
  
  Anat. Embry. 211(2)
  
  Pages: 95-100
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390052
[Journal Article] 消化管壁筋層にみられるギャップ結合による細胞性ネットワーク-消化管運動ベースメーカー系-2004
- Author(s)
  中村桂一郎, 西井清雅, 他
- Journal Title
  
  日本薬理学雑誌 123(3)
  
  Pages: 134-140
- Data Source
  KAKENHI-PROJECT-16790126
[Journal Article] Conduction abnormality in gap junction protein connexin45-deficient embryonic stem cell-derived cardiac myocytes.2004
- Author(s)
  K.Egashira, K.Nishii, et al.
- Journal Title
  
  Anat.Rec. 280A(2)
  
  Pages: 973-979
- Data Source
  KAKENHI-PROJECT-16790126
[Journal Article] Conduction abnormality in gap junction protein connexin45-deficient embryonic stem cell-derived cardiac myocytes.2004
- Author(s)
  K.Egashira, K.Nishii, K.Nakamura, M.Kumai, S.Morimoto, Y.Shibata
- Journal Title
  
  Anat.Rec. 280A(2)
  
  Pages: 973-979
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390057
[Journal Article] ギャップ結合蛋白の多様な発現と機能2004
- Author(s)
  柴田洋三郎, 西井清雅
- Journal Title
  
  細胞The CELL 36(11)
  
  Pages: 26-29
- Data Source
  KAKENHI-PROJECT-16790126
[Journal Article] Mice lacking connexin45 conditionally in cardiac myocytes display embryonic lethality similar to that of germline knockout mice without endocardial cushion defect2003
- Author(s)
  K.Nishii et al.
- Journal Title
  
  Cell Commun.Adhesion 10
  
  Pages: 365-369
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390057
[Journal Article] Mice lacking connexin45 conditionally in cardiac myocytes display embryonic lethality similar to that of germline knockout mice without endocardial cushion defect.2003
- Author(s)
  K.Nishii, M.Kumai, K.Egashira, T.Miwa, K.Hashizume, Y.Miyano, Y.Shibata
- Journal Title
  
  Cell Commun. Adhesion 10
  
  Pages: 365-369
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390057
[Presentation] Role of connexins on cardiac arrhythmia2014
- Author(s)
  関　明子、西井　清雅、柴田　洋三郎、小林　靖、萩原　誠久
- Organizer
  第91回日本生理学会大会
- Place of Presentation
  鹿児島大学（鹿児島）
- Invited
- Data Source
  KAKENHI-PROJECT-23591091
[Presentation] 網膜電気シナプスはカルシウム依存転写因子NFATの活性化に必要である2014
- Author(s)
  西井清雅、関明子、David L. Paul、萩原誠久、小林靖
- Organizer
  第119回日本解剖学会総会・全国学術集会
- Place of Presentation
  自治医科大学(下野)(3/27-29)
- Year and Date
  2014-03-29
- Data Source
  KAKENHI-PROJECT-23591091
[Presentation] 網膜電気シナプスはカルシウム依存転写因子NFATの活性化に必要である2014
- Author(s)
  西井　清雅、関　明子、David L. Paul、萩原　誠久、小林　靖
- Organizer
  第119回日本解剖学会総会・全国学術集会
- Place of Presentation
  自治医科大学（下野）
- Data Source
  KAKENHI-PROJECT-23591091
[Presentation] Cx knock-outと不整脈. Role of connexins on cardiac arrhythmia(シンポジウム:心筋ギャップ結合機能調節機構とその病態,招待)2014
- Author(s)
  関明子、西井清雅、柴田洋三郎、小林靖、萩原誠久
- Organizer
  第91回日本生理学会大会
- Place of Presentation
  鹿児島大学(鹿児島)(3/16-18)
- Year and Date
  2014-03-16
- Data Source
  KAKENHI-PROJECT-23591091
[Presentation] Connexin45 conducts essential myocardial functions during heart development.2013
- Author(s)
  西井　清雅、関　明子、熊井　まどか、森本　幸生、三輪　岳志、萩原　誠久、柴田　洋三郎、小林　靖
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  大阪大学（神戸）
- Data Source
  KAKENHI-PROJECT-23591091
[Presentation] Connexin45 conducts essential myocardial functions during heart development2013
- Author(s)
  西井清雅、関明子、熊井まどか、森本幸生、三輪岳志、萩原誠久、柴田洋三郎、小林靖
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  大阪大学(神戸)(12/3-6)
- Year and Date
  2013-12-03
- Data Source
  KAKENHI-PROJECT-23591091
[Presentation] Cx45ギャップ結合によるNFATc転写因子の細胞内局在制御2012
- Author(s)
  西井清雅、関明子、小林靖、柴田洋三郎
- Organizer
  第117回日本解剖学会総会・全国学術集会
- Place of Presentation
  山梨大学(山梨)
- Year and Date
  2012-03-27
- Data Source
  KAKENHI-PROJECT-22590197
[Presentation] Cx45ギャップ結合によるNFATc転写因子の細胞内局在制御2012
- Author(s)
  西井清雅、関明子、小林靖、柴田洋三郎
- Organizer
  第117回日本解剖学会総会・全国学術集会
- Place of Presentation
  甲府
- Year and Date
  2012-03-27
- Data Source
  KAKENHI-PROJECT-22590197
[Presentation] 発生初期心拍動に異常を示す遺伝子変異マウスの心拍動画像解析2011
- Author(s)
  西井清雅、関明子、小林靖、柴田洋三郎
- Organizer
  第88回日本生理学会大会第116回日本解剖学会総会・全国学術集会合同大会
- Place of Presentation
  横浜
- Year and Date
  2011-03-28
- Data Source
  KAKENHI-PROJECT-22590197
[Presentation] 発生初期心拍動に異常を示す遺伝子変異マウスの心拍動画像解析2011
- Author(s)
  西井清雅、関明子、小林靖、柴田洋三郎
- Organizer
  第116回日本解剖学会総会
- Place of Presentation
  パシフィコ横浜(神奈川県)
- Year and Date
  2011-03-28
- Data Source
  KAKENHI-PROJECT-22590197
[Presentation] 胎生初期心拍動に異常を示す遺伝子変異マウスの心拍動パターン解析2010
- Author(s)
  西井清雅、関明子、小林靖、柴田洋三郎
- Organizer
  第33回日本分子生物学会年会
- Place of Presentation
  神戸ポートアイランド(兵庫県)
- Year and Date
  2010-12-08
- Data Source
  KAKENHI-PROJECT-22590197
[Presentation] 胎生初期心拍動に異常を示す遺伝子変異マウスの心拍動パターン解析2010
- Author(s)
  西井清雅、関明子、小林靖、柴田洋三郎
- Organizer
  第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Year and Date
  2010-12-08
- Data Source
  KAKENHI-PROJECT-22590197

1. INAI Tetsuichiro (00264044)

# of Collaborated Projects: 10 results

# of Collaborated Products: 0 results
2. SHIBATA Yosaburo (90037482)

# of Collaborated Projects: 10 results

# of Collaborated Products: 4 results
3. NAKAMURA Kei-ichiro (20172398)

# of Collaborated Projects: 9 results

# of Collaborated Products: 1 results
4. 倉岡晃夫 (30253412)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. OKABE Shigeo (60204012)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. TANAKA Shinji (00529034)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. IWASAKI Hirohide (30342752)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. KONDO Satoru (20301757)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. NISHII Akiko (80408608)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. HIROSE Eiji (40380620)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 関明子

# of Collaborated Projects: 0 results

# of Collaborated Products: 6 results

Nishii Kiyomasa 西井 清雅

NISHII Kiyomasa 西井 清雅

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Biometric analysis of organogenesisPrincipal Investigator

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核-細胞質間輸送の制御下にあるシナプス可塑性形成機構の可視化Principal Investigator

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初期心拍動に異常を示す遺伝子変異マウスの解析Principal Investigator

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Diversity of tight junction protein, claudin, in mouse tissues and significance of binding between claudin and ZO-1Principal Investigator

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心筋に発現するギャップ結合コネキシン蛋白の条件下欠損マウスの作製と、その解析Principal Investigator

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Nishii Kiyomasa 西井清雅

NISHII Kiyomasa 西井清雅