Nishii Akiko 西井明子 (関明子)

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西井明子ニシイアキコ

関明子

NISHII Akiko 西井明子

関明子

西井明子(関明子) ニシイアキコ

SEKI Akiko 関明子

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Researcher Number	80408608
Other IDs
Affiliation (Current)	2025: 東京女子医科大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2022 – 2023: 東京女子医科大学, 医学部, 教授 2020 – 2021: 東京女子医科大学, 医学部, 准教授 2019: 東京女子医科大学, 医学部, 講師 2018: 東京女子医科大学, 医学部, 助教 2009 – 2013: 東京女子医科大学, 医学部, 助教 2007: Tokyo Women's Medical University, 医学部, 助教 2006: 東京女子医科大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Circulatory organs internal medicine / Basic Section 53020:Cardiology-related Except Principal Investigator Medium-sized Section 53:Organ-based internal medicine and related fields / Circulatory organs internal medicine
Keywords	Principal Investigator ギャップジャンクション / コネキシン45 / ゲノム編集 / 電気生理学的性質 / iPS細胞由来心筋細胞 / パリティ保障機構 / 刺激伝導系 / コネキシン / 伝導障害 / ノックアウトマウス … More / パリティ保証機構 / 洞結節 / pHゲーティング / シングルチャネル / 細胞内ループ / ペプタイド / パッチクランプ / コネキシン43 … More Except Principal Investigator 心臓伝導障害 / 光学マッピング / 歯骨格異常 / 進行性心臓伝導障害 / コネキシン / Crispr/cas9ゲノム編集 / Crispr/Cas9ゲノム編集 / 歯骨形成異常 / コネキシン４５ / 胎生致死 / ゲノム編集 / CRISPR/Cas9 / ノックインマウス / コネキシン45 / コネキシン40 / ギャップ結合 / 遺伝子 / 致死性不整脈 / ギャップジャンクション Less

Cx45R75H変異疾患特異的iPS心筋細胞の性質に関する検討Principal Investigator
- Principal Investigator
  
  西井明子 (関明子)
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Tokyo Women's Medical University
Novel pathophysiology underlying cardiac conduction defect due to mutations of gap junction genes
- Principal Investigator
  
  Makita Naomasa
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 53:Organ-based internal medicine and related fields
- Research Institution
  National Cardiovascular Center Research Institute
  Nagasaki University
Parity check by gap junctions maintains normal cardiac conduction in sinoatrial nodePrincipal Investigator
- Principal Investigator
  
  NISHII Akiko
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Tokyo Women's Medical University
Mutations in cardiac gap junction genes and the pathophysiology underlying progressive cardiac conduction defect.
- Principal Investigator
  
  MAKITA Naomasa
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Nagasaki University
コネキシン43細胞内ループペプタイドによるギャップジャンクション標的治療法の研究Principal Investigator
- Principal Investigator
  
  関明子
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Tokyo Women's Medical University

All 2023 2019 2018 2014 2013 2012 2011 2009 2007 2006

All Journal Article Presentation

[Journal Article] Cardiac connexins, mutations and arrhythmias2012
- Author(s)
  Delmar M, Makita N
- Journal Title
  
  Curr Opin Cardiol
  
  Volume: (in press) Issue: 1 Pages: 163-172
- DOI
  10.1161/circep.111.967604
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590921, KAKENHI-PLANNED-22113009, KAKENHI-PLANNED-22136007, KAKENHI-PROJECT-22390040, KAKENHI-PROJECT-23390209, KAKENHI-PROJECT-23591091, KAKENHI-PROJECT-24591038
[Journal Article] A Connexin 40 Mutation Associated with a Malignant Variant of Progressive Familial Heart Block Type-12012
- Author(s)
  Makita N, Seki A, Sumitomo N, et al
- Journal Title
  
  Circ Arrhythm Electrophysiol
  
  Volume: 5 Pages: 163-172
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590921
[Journal Article] A crucial role of activin A-mediated growth hormone suppression in mouse and human heart failure2011
- Author(s)
  Fukushima N, Seki A, et al
- Journal Title
  
  PLoS One
  
  Volume: 6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590921
[Journal Article] A crucial role of activin A-mediated growth hormone suppression in mouse and human heart failure2011
- Author(s)
  Fukushima N, Matsuura K, Akazawa H, Honda A, Nagai T, Takahashi T, Seki A, Murasaki KM, Shimizu T, Okano T, Hagiwara N, Komuro I
- Journal Title
  
  PLoS One
  
  Volume: 6 Issue: 12 Pages: e27901-e27901
- DOI
  10.1371/journal.pone.0027901
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21229010, KAKENHI-PROJECT-22390156, KAKENHI-PROJECT-23390213, KAKENHI-PROJECT-23591091
[Journal Article] ギャップジャンクションチャネルの化学的ゲーティング機構: コネキシン43のカルボキシル末端の役割について2007
- Author(s)
  関明子萩原誠久 Steven M Taffet Mario Delmar 笠貫宏
- Journal Title
  
  心電図 27(3)
  
  Pages: 196-203
- NAID
  10019491957
- Data Source
  KAKENHI-PROJECT-18790515
[Journal Article] Effect of charge substitutions at residue his-142 on voltage gating of connexin43 channels.2006
- Author(s)
  Shibayama J, Gutierrez C, Gonzalez D, Kieken F, Seki A, Carrion JR, Sorgen PL, Taffet SM, Barrio LC, Delmar M
- Journal Title
  
  Biophys J. 91(11)
  
  Pages: 4054-4063
- Data Source
  KAKENHI-PROJECT-18790515
[Presentation] ヒトiPS細胞およびIPS心筋細胞におけるコネキシン45変異による影響2023
- Author(s)
  古谷喜幸, 羽山恵美子, 西井明子, 川口奈奈子, 島田光世, 松岡瑠美子, 中西敏雄, 稲井慶
- Organizer
  日本小児循環器学会
- Data Source
  KAKENHI-PROJECT-21K08040
[Presentation] 進行性心臓伝導障害患者の網羅的遺伝子解析とin vitro 機能解析系を用いて明らかになった心臓コネキシン病の分子病態2019
- Author(s)
  石川泰輔, 関明子, 蒔田直昌
- Organizer
  第97回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-18K19550
[Presentation] Cardiac Connexin Syndrome: A New Inherited Cardiac Conduction Disease Entity with Distinct Electrophysiological and Extracardiac Manifestations.2018
- Author(s)
  Ishikawa T., Seki A., Hagiwara N., Makita N.
- Organizer
  第82回日本循環器学会学術大会
- Data Source
  KAKENHI-PROJECT-18K19550
[Presentation] Role of connexins on cardiac arrhythmia2014
- Author(s)
  関　明子、西井　清雅、柴田　洋三郎、小林　靖、萩原　誠久
- Organizer
  第91回日本生理学会大会
- Place of Presentation
  鹿児島大学（鹿児島）
- Invited
- Data Source
  KAKENHI-PROJECT-23591091
[Presentation] 網膜電気シナプスはカルシウム依存転写因子NFATの活性化に必要である2014
- Author(s)
  西井清雅、関明子、David L. Paul、萩原誠久、小林靖
- Organizer
  第119回日本解剖学会総会・全国学術集会
- Place of Presentation
  自治医科大学(下野)(3/27-29)
- Year and Date
  2014-03-29
- Data Source
  KAKENHI-PROJECT-23591091
[Presentation] 網膜電気シナプスはカルシウム依存転写因子NFATの活性化に必要である2014
- Author(s)
  西井　清雅、関　明子、David L. Paul、萩原　誠久、小林　靖
- Organizer
  第119回日本解剖学会総会・全国学術集会
- Place of Presentation
  自治医科大学（下野）
- Data Source
  KAKENHI-PROJECT-23591091
[Presentation] Cx knock-outと不整脈. Role of connexins on cardiac arrhythmia(シンポジウム:心筋ギャップ結合機能調節機構とその病態,招待)2014
- Author(s)
  関明子、西井清雅、柴田洋三郎、小林靖、萩原誠久
- Organizer
  第91回日本生理学会大会
- Place of Presentation
  鹿児島大学(鹿児島)(3/16-18)
- Year and Date
  2014-03-16
- Data Source
  KAKENHI-PROJECT-23591091
[Presentation] Connexin45 conducts essential myocardial functions during heart development.2013
- Author(s)
  西井　清雅、関　明子、熊井　まどか、森本　幸生、三輪　岳志、萩原　誠久、柴田　洋三郎、小林　靖
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  大阪大学（神戸）
- Data Source
  KAKENHI-PROJECT-23591091
[Presentation] Connexin45 conducts essential myocardial functions during heart development2013
- Author(s)
  西井清雅、関明子、熊井まどか、森本幸生、三輪岳志、萩原誠久、柴田洋三郎、小林靖
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  大阪大学(神戸)(12/3-6)
- Year and Date
  2013-12-03
- Data Source
  KAKENHI-PROJECT-23591091
[Presentation] Inhibition of Activin A is the Novel Therapeutic Target for Heart Failure.2011
- Author(s)
  Fukushima N、Matsuura K、Akazawa H、Honda A、Nagai T、Takahashi M、 Seki A、Murasaki K、Shimizu T、Okano M、Hagiwara N、 Komuro I.
- Organizer
  Scientific sessions 2011. American Heart Association
- Place of Presentation
  Orland, Florida, USA
- Data Source
  KAKENHI-PROJECT-23591091
[Presentation] 家族性進行性心臓伝導障害のコネキシン40遺伝子異変と機能解析2009
- Author(s)
  蒔田直昌、住友直方、関明子
- Organizer
  平成21年度生理学研究所研究会
- Place of Presentation
  岡崎
- Year and Date
  2009-11-25
- Data Source
  KAKENHI-PROJECT-21590921
[Presentation] Familial isolated cardiac conduction defect associated with a mutation in the connexin40 gene GJA52009
- Author(s)
  Makita N, Sumitomo N, Seki A, et al
- Organizer
  The 36th Congress of the International Union of Physiological Sciences
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-21590921
[Presentation] 家族性進行性心臓伝導障害に同定されたconnexin40遺伝子GJA5異変の機能異常2009
- Author(s)
  蒔田直昌、住友直方、関明子
- Organizer
  心電学フロンティア2009(第44回理論心電図研究会)
- Place of Presentation
  京都
- Year and Date
  2009-07-03
- Data Source
  KAKENHI-PROJECT-21590921
[Presentation] 家族性進行性心臓伝導障害に同定されたconnexin40遺伝子変異の機能異常2009
- Author(s)
  蒔田直昌、住友直方、関明子
- Organizer
  第8回コネキシン研究会
- Place of Presentation
  福岡
- Year and Date
  2009-11-27
- Data Source
  KAKENHI-PROJECT-21590921

1. MAKITA Naomasa (00312356)

# of Collaborated Projects: 2 results

# of Collaborated Products: 8 results
2. SUMITOMO Naokata (50231379)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
3. NISHII Kiyomasa (20264020)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
4. 柴田恭明 (80253673)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 本荘晴朗 (70262912)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 羽山恵美子 (00349698)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. 古谷喜幸 (10424673)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. 永井敏雄

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 小室一成

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Nishii Akiko 西井 明子 (関 明子)

西井 明子 ニシイ アキコ

関明子

NISHII Akiko 西井 明子

関 明子

西井 明子(関明子) ニシイ アキコ

SEKI Akiko 関 明子

Research Projects

Research Products

Co-Researchers

Cx45R75H変異疾患特異的iPS心筋細胞の性質に関する検討Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Novel pathophysiology underlying cardiac conduction defect due to mutations of gap junction genes

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Parity check by gap junctions maintains normal cardiac conduction in sinoatrial nodePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Mutations in cardiac gap junction genes and the pathophysiology underlying progressive cardiac conduction defect.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

コネキシン43細胞内ループペプタイドによるギャップジャンクション標的治療法の研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Cardiac connexins, mutations and arrhythmias2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A Connexin 40 Mutation Associated with a Malignant Variant of Progressive Familial Heart Block Type-12012

Author(s)

Journal Title

Data Source

[Journal Article] A crucial role of activin A-mediated growth hormone suppression in mouse and human heart failure2011

Author(s)

Journal Title

Data Source

[Journal Article] A crucial role of activin A-mediated growth hormone suppression in mouse and human heart failure2011

Author(s)

Journal Title

DOI

Data Source

[Journal Article] ギャップジャンクションチャネルの化学的ゲーティング機構: コネキシン43のカルボキシル末端の役割について2007

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Effect of charge substitutions at residue his-142 on voltage gating of connexin43 channels.2006

Author(s)

Journal Title

Data Source

[Presentation] ヒトiPS細胞およびIPS心筋細胞におけるコネキシン45変異による影響2023

Author(s)

Organizer

Data Source

[Presentation] 進行性心臓伝導障害患者の網羅的遺伝子解析とin vitro 機能解析系を用いて明らかになった心臓コネキシン病の分子病態2019

Author(s)

Organizer

Data Source

[Presentation] Cardiac Connexin Syndrome: A New Inherited Cardiac Conduction Disease Entity with Distinct Electrophysiological and Extracardiac Manifestations.2018

Author(s)

Organizer

Data Source

[Presentation] Role of connexins on cardiac arrhythmia2014

Nishii Akiko 西井明子 (関明子)

西井明子ニシイアキコ

NISHII Akiko 西井明子

関明子

西井明子(関明子) ニシイアキコ

SEKI Akiko 関明子