Onizuka Shin 鬼塚信

… Alternative Names

鬼塚信オニヅカシン

ONIZUKA Shin 鬼塚信

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Researcher Number	20264393
Other IDs
Affiliation (Current)	2025: 九州医療科学大学, 社会福祉学部, 教授
Affiliation (based on the past Project Information) *help	2025: 九州医療科学大学, 社会福祉学部, 教授 2022 – 2023: 九州保健福祉大学, 社会福祉学部, 教授 2015 – 2020: 九州保健福祉大学, 保健科学部, 教授 2007 – 2012: University of Miyazaki, 医学部, 助教 2008: University of Miyazaki, 医学科, 助教 … More 2005 – 2006: 宮崎大学, 医学部, 助手 1999 – 2001: 宮崎医科大学, 医学部, 助手 1995: 宮崎医科大学, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator Anesthesiology/Resuscitation studies / Basic Section 55050:Anesthesiology-related / Anesthesiology/Resuscitation studies / Anesthesiology Except Principal Investigator Anesthesiology/Resuscitation studies / Anesthesiology/Resuscitation studies
Keywords	Principal Investigator リドカイン / 局所麻酔薬 / 麻酔薬 / アポトーシス / プロポフォール / セボフルラン / 癌抑制遺伝子 / DNA脱メチル化 / ミトコンドリア / パッチクランプ … More / NF-κB / 癌特異抗原 / CD86 / CD80 / PDL1 / PD1 / 免疫チェックポイント分子 / 免疫記憶 / 免疫寛容 / 移植免疫 / 腫瘍免疫 / 免疫チェックポイント / Th細胞パラダイム / エピジェネティック / リアルタイムPCR / HAPⅡ / メチル化感受性制限酵素 / CpG Methyltransferase / メチル化特異的定量的リアルタイムPCR法 / p53 / リアルタイムPCR法 / DNAドットブロット法 / メチル化DNA特異抗体 / MSP法 / DNAメチル化 / イオントラッピング / 細胞内pH / ミトコンドリア電位 / 脱共役作用 / プロトントラッピング / プロトノフォア / pH勾配 / プロポフオール / 抗癌作用 / Sodium currents / Internal perfusion / Sevoflurane / ナトリウム電流 / ナトリウムチャネル / セボフルレン / 細胞内灌流 / パッチクランプ法 / プロカイン / 細胞内ATP濃度 / 腫瘍特異性 / アルカリ化 / 腫瘍細胞 / 麻酔学 / MED64 / 興奮 / 中枢神経 / 水棲かたつむり / アセチルコリン作動性シナプス / 抑制性シナプス / アセチルコリン / Lvmnaea Stagnalis / Inhibitory synapse / Excitatory synapse / Dopamine / NGF / GABA / Dopamin / RPeD1 / Lymnaea stagnalis / Synapse / 髄腔内投与 / カプサイシン … More Except Principal Investigator Lymnaea stagnalis / リドカイン / シナプス / burst spike / multielectrode / Lidocaine / Lymnaea, stagnalis / 培養細胞 / 水棲カタツムリ / 群発発射 / MED64 / 局所麻酔薬 / 中枢神経節 / 水棲かたつむり / calcium concentration / Sevoflurane / Volatile anesthetics / Respiration / Lymnaea stagnalils / カルシウム濃度 / セボフルラン / 吸入麻酔薬 / 呼吸 / 生理活性 / 神経成長因子 Less

麻酔薬の免疫チェックポイントを介したTh細胞パラダイム誘導による免疫応答の探索Principal Investigator
- Principal Investigator
  
  鬼塚信
- Project Period (FY)
  2025 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55050:Anesthesiology-related
- Research Institution
  Kyushu University of Medical Science
Examination of anesthetics that are advantageous for tumor immunity targeting cancer specific antigens, cancer specific antigensPrincipal Investigator
- Principal Investigator
  
  鬼塚信
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55050:Anesthesiology-related
- Research Institution
  Kyushu University of Health and Welfare
Elucidation of DNA demethylation mechanism of local anesthetic and its usefulness for anesthesia, cancer treatment, regenerative medicine.Principal Investigator
- Principal Investigator
  
  Shin Onizuka
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55050:Anesthesiology-related
- Research Institution
  Kyushu University of Health and Welfare
Search of optimal anesthetic in cancer patients was evaluated from apoptosis induced cancer cellsPrincipal Investigator
- Principal Investigator
  
  Onizuka Shin
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology
- Research Institution
  Kyushu University of Health and Welfare
局所麻酔薬のDNA脱メチル化による腫瘍細胞増殖抑制および致死機序の解明Principal Investigator
- Principal Investigator
  
  鬼塚信
- Project Period (FY)
  2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  University of Miyazaki
The mechanisms of lidocaine induce apoptosis in cancer cellsPrincipal Investigator
- Principal Investigator
  
  ONIZUKA Shin
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  University of Miyazaki
腫瘍分泌生理活性物質によるシナプス伝達機構の修飾
- Principal Investigator
  
  高崎真弓
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  University of Miyazaki
The mechanism of local anesthetics induced convulsionPrincipal Investigator
- Principal Investigator
  
  ONIZUKA Shin
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  University of Miyazaki
Effects of local anesthetics on the soma and axon in cultured neuron of Lymnaea stagnalis
- Principal Investigator
  
  KASABA Toshiharu
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  University of Miyazaki
Effect of sevoflurane on the voltage-dependent sodium currents in a Lymnaea neuronPrincipal Investigator
- Principal Investigator
  
  ONIZUKA Shin
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  University of Miyazaki
神経成長因子の神経細胞シナプス再構築過程への影響Principal Investigator
- Principal Investigator
  
  鬼塚信
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  宮崎医科大学
Effect of volatile anesthetics on Cultured Neuron of Lymnaea stagnalis
- Principal Investigator
  
  KASABA Toshiharu
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  Miyazaki Medical College
NMDA投与による痛みの慢性化に関する研究Principal Investigator
- Principal Investigator
  
  鬼塚信
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  宮崎医科大学

All 2024 2022 2021 2020 2019 2018 2017 2015 2012 2011 2010 2009 2008

All Journal Article Presentation

[Journal Article] Lidocaine treatment during synapse reformation periods permanently inhibits NGF-induced excitation in an identified reconstructed synapse of Lymnaea stagnalis2012
- Author(s)
  Onizuka S, Shiraishi S, Tamura R, YonahaT, Oda N, Kawasaki Y, Syed NI, ShirasakaT, and Tsuneyoshi I
- Journal Title
  
  J Anesth
  
  Volume: 26 Pages: 45-53
- NAID
  10030449380
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591978
[Journal Article] Clinical dose of lidocaine destroys cell membrane and induces both necrosis and apoptos is inan identified Lymnaea neuron2012
- Author(s)
  Onizuka S, Tamura R, Yonaha T, Oda N, Kawasaki Y, Shirasaka T, Shiraishi S, and Tsuneyoshi I
- Journal Title
  
  J Anesth
  
  Volume: 26 Pages: 54-61
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591978
[Journal Article] Capsaicin indirectly suppresses voltage-gated Na+ currents through TRPV1 in rat dorsal root ganglion neurons2011
- Author(s)
  Onizuka Shin
- Journal Title
  
  nesthesia and analgesia
  
  Volume: 112 Pages: 703-709
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591978
[Journal Article] Local anesthetics depolarize mitochondrial membrane potential by intracellular alkalization in rat dorsal root ganglion neurons.2011
- Author(s)
  Onizuka S, Tamura R, Hosokawa N, Kawasaki Y, Tsuneyoshi I.
- Journal Title
  
  Anesth Analg.
  
  Volume: 111 Pages: 775-783
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591978
[Journal Article] Lidocaine depolarizes the mitochondrial membrane potential by intracellular alkalization in rat dorsal root ganglion neurons2011
- Author(s)
  Onizuka S, Yonaha T, Tamura R, Kasiwada M, Shirasaka T, Tsuneyoshi I
- Journal Title
  
  J Anesth
  
  Volume: 25 Pages: 229-39
- NAID
  10029022520
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591978
[Journal Article] Lidocaine depolarizes the mitochondrial membrane potential by intracellular alkalization in rat dorsal root ganglion neurons.2011
- Author(s)
  Onizuka S, Yonaha T, Tamura R, Kasiwada M, Shirasaka T, Tsuneyoshi I.
- Journal Title
  
  J Anesth.
  
  Volume: 25 Pages: 229-239
- NAID
  10029022520
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591978
[Journal Article] Local Anesthetics with High Lipophilicity are Toxic, While Local Anesthetics with Low pka Induce More Apoptosis in Human Leukemia Cells2011
- Author(s)
  Onizuka S, YonahaT, TsuneyoshiI
- Journal Title
  
  J Anesthe Clinic Res
  
  Volume: 2 Pages: 116-21
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591978
[Journal Article] Local Anesthetics with High Lipophilicity are Toxic, While Local Anesthetics with Low pka Induce More Apoptosis in Human Leukemia Cells2011
- Author(s)
  Onizuka Shin
- Journal Title
  
  Anesthesia and Clinical Research
  
  Volume: 2 Pages: 116-121
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591978
[Journal Article] Capsaicin indirectly suppresses voltage-gated Na+ currents through TRPV1 in rat dorsal root ganglion neurons2011
- Author(s)
  Onizuka S, Yonaha T, Tamura R, HosokawaN, Kawasaki Y, Kashiwada M, Shirasaka T, Tsuneyoshi I
- Journal Title
  
  Anesth Analg
  
  Volume: 112 Pages: 703-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591978
[Journal Article] Local Anesthetics with High Lipophilicity are Toxic, While Local Anesthetics with Low pka Induce More Apoptosis in Human Leukemia Cells2011
- Author(s)
  Shin Onizuka, Tetsu Yonaha, Isao Tsuneyoshi
- Journal Title
  
  J Anesthe Clinic Res.
  
  Volume: 21 Pages: 11-16
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591978
[Journal Article] Lidocaine depolarizes the mitochondrial membrane potential by intracellular alkalization in rat dorsal root ganglion neurons2011
- Author(s)
  Onizuka Shin
- Journal Title
  
  Journal of anesthesia
  
  Volume: 25 Pages: 229-239
- NAID
  10029022520
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591978
[Journal Article] Local anesthetics depolarize mitochondrial membrane potential by intracellular alkalization in rat dorsal root ganglion neurons2010
- Author(s)
  Onizuka S, Tamura R, Hosokawa N, Kawasaki Y, Tsuneyoshi I
- Journal Title
  
  Anesthesia and analgesia
  
  Volume: 111 Pages: 775-83
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591978
[Journal Article] The effect of lidocaine on cholinergic neurotransmission in an identified reconstructed synapse.2008
- Author(s)
  Onizuka s, Kasaba T, Takasaki M.
- Journal Title
  
  Anesth Analg 107
  
  Pages: 1236-1242
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591807
[Journal Article] The effect of lidocaine on cholinergic neurotransmission in an identified reconstrueted synapse2008
- Author(s)
  Shin Onizuka
- Journal Title
  
  Anesthesia and Analgesia 107
  
  Pages: 1236-1242
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591809
[Journal Article] Lidocaine Increases the Intracellular Na+ Concentration through Na+-K+ ATPase in an Lymnaea Neuron.2008
- Author(s)
  Onizuka S, Kasaba T, Tamura R, Takasaki M
- Journal Title
  
  Anesth Analg 106
  
  Pages: 1465-1472
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591807
[Journal Article] The effect of lidocaine on cholinergic neurotransmission in an identified reconstructed synapse2008
- Author(s)
  Onizuka S, Kasaba T, Takasaki M.
- Journal Title
  
  Anesth Analg 107
  
  Pages: 1236-42
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591807
[Journal Article] Lidocaine Increases the Intracellular Na+ Concentration through Na+-K+ ATPase in an Lymnaea Neuron2008
- Author(s)
  Onizuka S, Kasaba T, Tamura R, Takasaki M.
- Journal Title
  
  Anesth Analg 106
  
  Pages: 1465-72
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591807
[Presentation] 抗原提示細胞とTh細胞パラダイムを介した腫瘍免疫に及ぼす麻酔薬の影響2024
- Author(s)
  鬼塚信
- Organizer
  日本麻酔科学会
- Data Source
  KAKENHI-PROJECT-22K09108
[Presentation] 抗原提示細胞とTh細胞パラダイムを介した腫瘍免疫に及ぼす麻酔薬の影響2022
- Author(s)
  鬼塚　信
- Organizer
  第69回日本麻酔科学会（神戸市）
- Data Source
  KAKENHI-PROJECT-22K09108
[Presentation] 麻酔薬は、NF-κBシグナル伝達経路を介して腫瘍免疫に影響を及ぼす。新開発DNA蛍光プローブを用いた検証。2021
- Author(s)
  鬼塚　信
- Organizer
  日本麻酔科学会第68回学術集会
- Data Source
  KAKENHI-PROJECT-18K08839
[Presentation] 麻酔薬は、NF-κBシグナル伝達経路を介して腫瘍免疫に影響を及ぼす。2020
- Author(s)
  鬼塚　信
- Organizer
  日本麻酔科学会第67回学術集会
- Data Source
  KAKENHI-PROJECT-18K08839
[Presentation] 麻酔薬の癌細胞における免疫チェックポイント分子に及ぼす影響2019
- Author(s)
  鬼塚信、白石成二
- Organizer
  日本麻酔科学会
- Data Source
  KAKENHI-PROJECT-18K08839
[Presentation] 局所麻酔薬の DNA脱メチル化機序2018
- Author(s)
  鬼塚　信
- Organizer
  日本麻酔科学会第65回学術集会
- Data Source
  KAKENHI-PROJECT-18K08839
[Presentation] プロポフォールの細胞毒性機序2017
- Author(s)
  鬼塚　信
- Organizer
  日本麻酔科学会
- Data Source
  KAKENHI-PROJECT-15K10527
[Presentation] 麻酔薬および抗がん剤のミトコンドリア遺伝子発現への影響2015
- Author(s)
  鬼塚　信
- Organizer
  日本麻酔科学会
- Place of Presentation
  神戸市国際コンベンションセンター
- Year and Date
  2015-05-29
- Data Source
  KAKENHI-PROJECT-15K10527
[Presentation] 培養腫瘍細胞からの腫瘍致死因子(TNF-α)の分泌2011
- Author(s)
  鬼塚信, 田中信彦, 與那覇哲, 田村隆二, 恒吉勇男
- Organizer
  日本麻酔科学会第58回学術集会
- Place of Presentation
  神戸
- Year and Date
  2011-05-19
- Data Source
  KAKENHI-PROJECT-21591978
[Presentation] リドカインによるミトコンドリア経路のアポトーシス誘発について:腫瘍細胞を用いた検討2010
- Author(s)
  鬼塚信, 山下幸貴, 田村隆二, 恒吉勇男
- Organizer
  日本麻酔科学会第57回学術集会
- Place of Presentation
  福岡
- Year and Date
  2010-06-03
- Data Source
  KAKENHI-PROJECT-21591978
[Presentation] リドカインによるミトコンドリア経路のアポトロシス誘発について:腫瘍細胞を用いた検討2010
- Author(s)
  鬼塚信、山下幸貴、田村隆二、恒吉勇男
- Organizer
  日本麻酵科学会第57回学術集会
- Place of Presentation
  福岡市
- Year and Date
  2010-06-03
- Data Source
  KAKENHI-PROJECT-21591978
[Presentation] 腫瘍細胞分泌液は,ラット脊髄神経節ニューロンにおいて電位依存性ナトリウムチャネルNaV1. 3の発現量を増加する2010
- Author(s)
  鬼塚信, 田中信彦, 與那覇哲, 田村隆二, 恒吉勇男
- Organizer
  九州麻酔科学会第48回大会
- Place of Presentation
  福岡
- Year and Date
  2010-09-25
- Data Source
  KAKENHI-PROJECT-21591978
[Presentation] リドカインはヒト白血病細胞にアポトーシスとネクローシスそれぞれを誘発する2009
- Author(s)
  鬼塚信, 山下幸貴, 田村隆二, 恒吉勇男
- Organizer
  日本麻酔科学会第56回学術集会
- Place of Presentation
  神戸
- Year and Date
  2009-08-18
- Data Source
  KAKENHI-PROJECT-21591978
[Presentation] リドカインの腫瘍細胞増殖抑制および致死機序の解明-細胞周期からのアプローチ2008
- Author(s)
  鬼塚信、田村隆二、三浦弘樹、恒吉勇男
- Organizer
  日本麻酔科学会第55回学術集会
- Place of Presentation
  横浜市
- Year and Date
  2008-06-12
- Data Source
  KAKENHI-PROJECT-19591807
[Presentation] Lidocaine depolarizes the mitochondrial membrane potential by proton trapping in anlymnaes neuron2008
- Author(s)
  Shin Onizuka, Kouki Yamashita, Ryuji Tamura, Isao Tsuneyoshi
- Organizer
  2008 Annual Meeting, American Society of Amesthesiologists
- Place of Presentation
  Orland, USA
- Year and Date
  2008-10-31
- Data Source
  KAKENHI-PROJECT-19591807
[Presentation] Lidocaine depolarizes the mitochondrial membrane potential by proton trapping in anlymnaea neuron.2008
- Author(s)
  Shin Onizuka, Kouki Yamaashita, Ryuji Tamura, Isao Tsuneyoshi
- Organizer
  2008 Annual Meeting, American Society of Anesthesiologists
- Place of Presentation
  アメリカ合衆国
- Data Source
  KAKENHI-PROJECT-19591807

1. KASABA Toshiharu (80145599)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
2. KASHIWADA Masatoshi (20336316)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. 高崎真弓 (30094212)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 白阪哲朗 (00274788)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 田村隆二 (40549060)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 与那覇哲 (70468023)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. HAMAKAWA Toshiro (50253836)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 成尾浩明 (10274797)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. SHIRAISHI Seiji (90216177)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Onizuka Shin 鬼塚 信

鬼塚 信 オニヅカ シン

ONIZUKA Shin 鬼塚 信

Research Projects

Research Products

Co-Researchers

麻酔薬の免疫チェックポイントを介したTh細胞パラダイム誘導による免疫応答の探索Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Examination of anesthetics that are advantageous for tumor immunity targeting cancer specific antigens, cancer specific antigensPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of DNA demethylation mechanism of local anesthetic and its usefulness for anesthesia, cancer treatment, regenerative medicine.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Search of optimal anesthetic in cancer patients was evaluated from apoptosis induced cancer cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

局所麻酔薬のDNA脱メチル化による腫瘍細胞増殖抑制および致死機序の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The mechanisms of lidocaine induce apoptosis in cancer cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

腫瘍分泌生理活性物質によるシナプス伝達機構の修飾

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The mechanism of local anesthetics induced convulsionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Effects of local anesthetics on the soma and axon in cultured neuron of Lymnaea stagnalis

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Effect of sevoflurane on the voltage-dependent sodium currents in a Lymnaea neuronPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

神経成長因子の神経細胞シナプス再構築過程への影響Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Effect of volatile anesthetics on Cultured Neuron of Lymnaea stagnalis

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

NMDA投与による痛みの慢性化に関する研究Principal Investigator

Principal Investigator

Onizuka Shin 鬼塚信

鬼塚信オニヅカシン

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