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Onizuka Shin  鬼塚 信

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… Alternative Names

鬼塚 信  オニヅカ シン

ONIZUKA Shin  鬼塚 信

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Researcher Number 20264393
Other IDs
Affiliation (Current) 2025: 九州医療科学大学, 社会福祉学部, 教授
Affiliation (based on the past Project Information) *help 2025: 九州医療科学大学, 社会福祉学部, 教授
2022 – 2023: 九州保健福祉大学, 社会福祉学部, 教授
2015 – 2020: 九州保健福祉大学, 保健科学部, 教授
2007 – 2012: University of Miyazaki, 医学部, 助教
2008: University of Miyazaki, 医学科, 助教 … More
2005 – 2006: 宮崎大学, 医学部, 助手
1999 – 2001: 宮崎医科大学, 医学部, 助手
1995: 宮崎医科大学, 医学部, 助手 Less
Review Section/Research Field
Principal Investigator
Anesthesiology/Resuscitation studies / Basic Section 55050:Anesthesiology-related / Anesthesiology/Resuscitation studies / Anesthesiology
Except Principal Investigator
Anesthesiology/Resuscitation studies / Anesthesiology/Resuscitation studies
Keywords
Principal Investigator
リドカイン / 局所麻酔薬 / 麻酔薬 / アポトーシス / プロポフォール / セボフルラン / 癌抑制遺伝子 / DNA脱メチル化 / ミトコンドリア / パッチクランプ … More / NF-κB / 癌特異抗原 / CD86 / CD80 / PDL1 / PD1 / 免疫チェックポイント分子 / 免疫記憶 / 免疫寛容 / 移植免疫 / 腫瘍免疫 / 免疫チェックポイント / Th細胞パラダイム / エピジェネティック / リアルタイムPCR / HAPⅡ / メチル化感受性制限酵素 / CpG Methyltransferase / メチル化特異的定量的リアルタイムPCR法 / p53 / リアルタイムPCR法 / DNAドットブロット法 / メチル化DNA特異抗体 / MSP法 / DNAメチル化 / イオントラッピング / 細胞内pH / ミトコンドリア電位 / 脱共役作用 / プロトントラッピング / プロトノフォア / pH勾配 / プロポフオール / 抗癌作用 / Sodium currents / Internal perfusion / Sevoflurane / ナトリウム電流 / ナトリウムチャネル / セボフルレン / 細胞内灌流 / パッチクランプ法 / プロカイン / 細胞内ATP濃度 / 腫瘍特異性 / アルカリ化 / 腫瘍細胞 / 麻酔学 / MED64 / 興奮 / 中枢神経 / 水棲かたつむり / アセチルコリン作動性シナプス / 抑制性シナプス / アセチルコリン / Lvmnaea Stagnalis / Inhibitory synapse / Excitatory synapse / Dopamine / NGF / GABA / Dopamin / RPeD1 / Lymnaea stagnalis / Synapse / 髄腔内投与 / カプサイシン … More
Except Principal Investigator
Lymnaea stagnalis / リドカイン / シナプス / burst spike / multielectrode / Lidocaine / Lymnaea, stagnalis / 培養細胞 / 水棲カタツムリ / 群発発射 / MED64 / 局所麻酔薬 / 中枢神経節 / 水棲かたつむり / calcium concentration / Sevoflurane / Volatile anesthetics / Respiration / Lymnaea stagnalils / カルシウム濃度 / セボフルラン / 吸入麻酔薬 / 呼吸 / 生理活性 / 神経成長因子 Less
  • Research Projects

    (13 results)
  • Research Products

    (33 results)
  • Co-Researchers

    (9 People)
  •  麻酔薬の免疫チェックポイントを介したTh細胞パラダイム誘導による免疫応答の探索Principal Investigator

    • Principal Investigator
      鬼塚 信
    • Project Period (FY)
      2025 – 2028
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55050:Anesthesiology-related
    • Research Institution
      Kyushu University of Medical Science
  •  Examination of anesthetics that are advantageous for tumor immunity targeting cancer specific antigens, cancer specific antigensPrincipal Investigator

    • Principal Investigator
      鬼塚 信
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55050:Anesthesiology-related
    • Research Institution
      Kyushu University of Health and Welfare
  •  Elucidation of DNA demethylation mechanism of local anesthetic and its usefulness for anesthesia, cancer treatment, regenerative medicine.Principal Investigator

    • Principal Investigator
      Shin Onizuka
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55050:Anesthesiology-related
    • Research Institution
      Kyushu University of Health and Welfare
  •  Search of optimal anesthetic in cancer patients was evaluated from apoptosis induced cancer cellsPrincipal Investigator

    • Principal Investigator
      Onizuka Shin
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Anesthesiology
    • Research Institution
      Kyushu University of Health and Welfare
  •  局所麻酔薬のDNA脱メチル化による腫瘍細胞増殖抑制および致死機序の解明Principal Investigator

    • Principal Investigator
      鬼塚 信
    • Project Period (FY)
      2012
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Anesthesiology/Resuscitation studies
    • Research Institution
      University of Miyazaki
  •  The mechanisms of lidocaine induce apoptosis in cancer cellsPrincipal Investigator

    • Principal Investigator
      ONIZUKA Shin
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Anesthesiology/Resuscitation studies
    • Research Institution
      University of Miyazaki
  •  腫瘍分泌生理活性物質によるシナプス伝達機構の修飾

    • Principal Investigator
      高崎 真弓
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Anesthesiology/Resuscitation studies
    • Research Institution
      University of Miyazaki
  •  The mechanism of local anesthetics induced convulsionPrincipal Investigator

    • Principal Investigator
      ONIZUKA Shin
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Anesthesiology/Resuscitation studies
    • Research Institution
      University of Miyazaki
  •  Effects of local anesthetics on the soma and axon in cultured neuron of Lymnaea stagnalis

    • Principal Investigator
      KASABA Toshiharu
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Anesthesiology/Resuscitation studies
    • Research Institution
      University of Miyazaki
  •  Effect of sevoflurane on the voltage-dependent sodium currents in a Lymnaea neuronPrincipal Investigator

    • Principal Investigator
      ONIZUKA Shin
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Anesthesiology/Resuscitation studies
    • Research Institution
      University of Miyazaki
  •  神経成長因子の神経細胞シナプス再構築過程への影響Principal Investigator

    • Principal Investigator
      鬼塚 信
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Anesthesiology/Resuscitation studies
    • Research Institution
      宮崎医科大学
  •  Effect of volatile anesthetics on Cultured Neuron of Lymnaea stagnalis

    • Principal Investigator
      KASABA Toshiharu
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Anesthesiology/Resuscitation studies
    • Research Institution
      Miyazaki Medical College
  •  NMDA投与による痛みの慢性化に関する研究Principal Investigator

    • Principal Investigator
      鬼塚 信
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Anesthesiology/Resuscitation studies
    • Research Institution
      宮崎医科大学

All 2024 2022 2021 2020 2019 2018 2017 2015 2012 2011 2010 2009 2008

All Journal Article Presentation

  • [Journal Article] Lidocaine treatment during synapse reformation periods permanently inhibits NGF-induced excitation in an identified reconstructed synapse of Lymnaea stagnalis2012

    • Author(s)
      Onizuka S, Shiraishi S, Tamura R, YonahaT, Oda N, Kawasaki Y, Syed NI, ShirasakaT, and Tsuneyoshi I
    • Journal Title

      J Anesth

      Volume: 26 Pages: 45-53

    • NAID

      10030449380

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591978
  • [Journal Article] Clinical dose of lidocaine destroys cell membrane and induces both necrosis and apoptos is inan identified Lymnaea neuron2012

    • Author(s)
      Onizuka S, Tamura R, Yonaha T, Oda N, Kawasaki Y, Shirasaka T, Shiraishi S, and Tsuneyoshi I
    • Journal Title

      J Anesth

      Volume: 26 Pages: 54-61

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591978
  • [Journal Article] Capsaicin indirectly suppresses voltage-gated Na+ currents through TRPV1 in rat dorsal root ganglion neurons2011

    • Author(s)
      Onizuka Shin
    • Journal Title

      nesthesia and analgesia

      Volume: 112 Pages: 703-709

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591978
  • [Journal Article] Local anesthetics depolarize mitochondrial membrane potential by intracellular alkalization in rat dorsal root ganglion neurons.2011

    • Author(s)
      Onizuka S, Tamura R, Hosokawa N, Kawasaki Y, Tsuneyoshi I.
    • Journal Title

      Anesth Analg.

      Volume: 111 Pages: 775-783

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591978
  • [Journal Article] Lidocaine depolarizes the mitochondrial membrane potential by intracellular alkalization in rat dorsal root ganglion neurons2011

    • Author(s)
      Onizuka S, Yonaha T, Tamura R, Kasiwada M, Shirasaka T, Tsuneyoshi I
    • Journal Title

      J Anesth

      Volume: 25 Pages: 229-39

    • NAID

      10029022520

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591978
  • [Journal Article] Lidocaine depolarizes the mitochondrial membrane potential by intracellular alkalization in rat dorsal root ganglion neurons.2011

    • Author(s)
      Onizuka S, Yonaha T, Tamura R, Kasiwada M, Shirasaka T, Tsuneyoshi I.
    • Journal Title

      J Anesth.

      Volume: 25 Pages: 229-239

    • NAID

      10029022520

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591978
  • [Journal Article] Local Anesthetics with High Lipophilicity are Toxic, While Local Anesthetics with Low pka Induce More Apoptosis in Human Leukemia Cells2011

    • Author(s)
      Onizuka S, YonahaT, TsuneyoshiI
    • Journal Title

      J Anesthe Clinic Res

      Volume: 2 Pages: 116-21

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591978
  • [Journal Article] Local Anesthetics with High Lipophilicity are Toxic, While Local Anesthetics with Low pka Induce More Apoptosis in Human Leukemia Cells2011

    • Author(s)
      Onizuka Shin
    • Journal Title

      Anesthesia and Clinical Research

      Volume: 2 Pages: 116-121

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591978
  • [Journal Article] Capsaicin indirectly suppresses voltage-gated Na+ currents through TRPV1 in rat dorsal root ganglion neurons2011

    • Author(s)
      Onizuka S, Yonaha T, Tamura R, HosokawaN, Kawasaki Y, Kashiwada M, Shirasaka T, Tsuneyoshi I
    • Journal Title

      Anesth Analg

      Volume: 112 Pages: 703-9

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591978
  • [Journal Article] Local Anesthetics with High Lipophilicity are Toxic, While Local Anesthetics with Low pka Induce More Apoptosis in Human Leukemia Cells2011

    • Author(s)
      Shin Onizuka, Tetsu Yonaha, Isao Tsuneyoshi
    • Journal Title

      J Anesthe Clinic Res.

      Volume: 21 Pages: 11-16

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591978
  • [Journal Article] Lidocaine depolarizes the mitochondrial membrane potential by intracellular alkalization in rat dorsal root ganglion neurons2011

    • Author(s)
      Onizuka Shin
    • Journal Title

      Journal of anesthesia

      Volume: 25 Pages: 229-239

    • NAID

      10029022520

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591978
  • [Journal Article] Local anesthetics depolarize mitochondrial membrane potential by intracellular alkalization in rat dorsal root ganglion neurons2010

    • Author(s)
      Onizuka S, Tamura R, Hosokawa N, Kawasaki Y, Tsuneyoshi I
    • Journal Title

      Anesthesia and analgesia

      Volume: 111 Pages: 775-83

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591978
  • [Journal Article] The effect of lidocaine on cholinergic neurotransmission in an identified reconstructed synapse.2008

    • Author(s)
      Onizuka s, Kasaba T, Takasaki M.
    • Journal Title

      Anesth Analg 107

      Pages: 1236-1242

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19591807
  • [Journal Article] The effect of lidocaine on cholinergic neurotransmission in an identified reconstrueted synapse2008

    • Author(s)
      Shin Onizuka
    • Journal Title

      Anesthesia and Analgesia 107

      Pages: 1236-1242

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20591809
  • [Journal Article] Lidocaine Increases the Intracellular Na+ Concentration through Na+-K+ ATPase in an Lymnaea Neuron.2008

    • Author(s)
      Onizuka S, Kasaba T, Tamura R, Takasaki M
    • Journal Title

      Anesth Analg 106

      Pages: 1465-1472

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19591807
  • [Journal Article] The effect of lidocaine on cholinergic neurotransmission in an identified reconstructed synapse2008

    • Author(s)
      Onizuka S, Kasaba T, Takasaki M.
    • Journal Title

      Anesth Analg 107

      Pages: 1236-42

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19591807
  • [Journal Article] Lidocaine Increases the Intracellular Na+ Concentration through Na+-K+ ATPase in an Lymnaea Neuron2008

    • Author(s)
      Onizuka S, Kasaba T, Tamura R, Takasaki M.
    • Journal Title

      Anesth Analg 106

      Pages: 1465-72

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19591807
  • [Presentation] 抗原提示細胞とTh細胞パラダイムを介した腫瘍免疫に及ぼす麻酔薬の影響2024

    • Author(s)
      鬼塚信
    • Organizer
      日本麻酔科学会
    • Data Source
      KAKENHI-PROJECT-22K09108
  • [Presentation] 抗原提示細胞とTh細胞パラダイムを介した腫瘍免疫に及ぼす麻酔薬の影響2022

    • Author(s)
      鬼塚 信
    • Organizer
      第69回日本麻酔科学会(神戸市)
    • Data Source
      KAKENHI-PROJECT-22K09108
  • [Presentation] 麻酔薬は、NF-κBシグナル伝達経路を介して腫瘍免疫に影響を及ぼす。 新開発DNA蛍光プローブを用いた検証。2021

    • Author(s)
      鬼塚 信
    • Organizer
      日本麻酔科学会第68回学術集会
    • Data Source
      KAKENHI-PROJECT-18K08839
  • [Presentation] 麻酔薬は、NF-κBシグナル伝達経路を介して腫瘍免疫に影響を及ぼす。2020

    • Author(s)
      鬼塚 信
    • Organizer
      日本麻酔科学会第67回学術集会
    • Data Source
      KAKENHI-PROJECT-18K08839
  • [Presentation] 麻酔薬の癌細胞における免疫チェックポイント分子に及ぼす影響2019

    • Author(s)
      鬼塚信、白石成二
    • Organizer
      日本麻酔科学会
    • Data Source
      KAKENHI-PROJECT-18K08839
  • [Presentation] 局所麻酔薬の DNA脱メチル化機序2018

    • Author(s)
      鬼塚 信
    • Organizer
      日本麻酔科学会第65回学術集会
    • Data Source
      KAKENHI-PROJECT-18K08839
  • [Presentation] プロポフォールの細胞毒性機序2017

    • Author(s)
      鬼塚 信
    • Organizer
      日本麻酔科学会
    • Data Source
      KAKENHI-PROJECT-15K10527
  • [Presentation] 麻酔薬および抗がん剤のミトコンドリア遺伝子発現への影響2015

    • Author(s)
      鬼塚 信
    • Organizer
      日本麻酔科学会
    • Place of Presentation
      神戸市国際コンベンションセンター
    • Year and Date
      2015-05-29
    • Data Source
      KAKENHI-PROJECT-15K10527
  • [Presentation] 培養腫瘍細胞からの腫瘍致死因子(TNF-α)の分泌2011

    • Author(s)
      鬼塚信, 田中信彦, 與那覇哲, 田村隆二, 恒吉勇男
    • Organizer
      日本麻酔科学会第58回学術集会
    • Place of Presentation
      神戸
    • Year and Date
      2011-05-19
    • Data Source
      KAKENHI-PROJECT-21591978
  • [Presentation] リドカインによるミトコンドリア経路のアポトーシス誘発について:腫瘍細胞を用いた検討2010

    • Author(s)
      鬼塚信, 山下幸貴, 田村隆二, 恒吉勇男
    • Organizer
      日本麻酔科学会第57回学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2010-06-03
    • Data Source
      KAKENHI-PROJECT-21591978
  • [Presentation] リドカインによるミトコンドリア経路のアポトロシス誘発について:腫瘍細胞を用いた検討2010

    • Author(s)
      鬼塚信、山下幸貴、田村隆二、恒吉勇男
    • Organizer
      日本麻酵科学会第57回学術集会
    • Place of Presentation
      福岡市
    • Year and Date
      2010-06-03
    • Data Source
      KAKENHI-PROJECT-21591978
  • [Presentation] 腫瘍細胞分泌液は,ラット脊髄神経節ニューロンにおいて電位依存性ナトリウムチャネルNaV1. 3の発現量を増加する2010

    • Author(s)
      鬼塚信, 田中信彦, 與那覇哲, 田村隆二, 恒吉勇男
    • Organizer
      九州麻酔科学会第48回大会
    • Place of Presentation
      福岡
    • Year and Date
      2010-09-25
    • Data Source
      KAKENHI-PROJECT-21591978
  • [Presentation] リドカインはヒト白血病細胞にアポトーシスとネクローシスそれぞれを誘発する2009

    • Author(s)
      鬼塚信, 山下幸貴, 田村隆二, 恒吉勇男
    • Organizer
      日本麻酔科学会第56回学術集会
    • Place of Presentation
      神戸
    • Year and Date
      2009-08-18
    • Data Source
      KAKENHI-PROJECT-21591978
  • [Presentation] リドカインの腫瘍細胞増殖抑制および致死機序の解明-細胞周期からのアプローチ2008

    • Author(s)
      鬼塚信、田村隆二、三浦弘樹、恒吉勇男
    • Organizer
      日本麻酔科学会第55回学術集会
    • Place of Presentation
      横浜市
    • Year and Date
      2008-06-12
    • Data Source
      KAKENHI-PROJECT-19591807
  • [Presentation] Lidocaine depolarizes the mitochondrial membrane potential by proton trapping in anlymnaes neuron2008

    • Author(s)
      Shin Onizuka, Kouki Yamashita, Ryuji Tamura, Isao Tsuneyoshi
    • Organizer
      2008 Annual Meeting, American Society of Amesthesiologists
    • Place of Presentation
      Orland, USA
    • Year and Date
      2008-10-31
    • Data Source
      KAKENHI-PROJECT-19591807
  • [Presentation] Lidocaine depolarizes the mitochondrial membrane potential by proton trapping in anlymnaea neuron.2008

    • Author(s)
      Shin Onizuka, Kouki Yamaashita, Ryuji Tamura, Isao Tsuneyoshi
    • Organizer
      2008 Annual Meeting, American Society of Anesthesiologists
    • Place of Presentation
      アメリカ合衆国
    • Data Source
      KAKENHI-PROJECT-19591807
  • 1.  KASABA Toshiharu (80145599)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 2.  KASHIWADA Masatoshi (20336316)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 3.  高崎 真弓 (30094212)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  白阪 哲朗 (00274788)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  田村 隆二 (40549060)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  与那覇 哲 (70468023)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  HAMAKAWA Toshiro (50253836)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  成尾 浩明 (10274797)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  SHIRAISHI Seiji (90216177)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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