IMAI Yoshinori 今井嘉紀

Researcher Number	20270689
Affiliation (based on the past Project Information) *help	2006: 愛媛大学, 大学院医学系研究科, 助教授 2003 – 2005: 愛媛大学, 医学部, 助教授 1999 – 2002: 国立精神・神経センター, 神経研究所・代謝研究部, 室長 1999 – 2001: 国立精神・神経センター, 代謝研究部, 室長 1998: 国立精神, 神経センター・神経研究所代謝研究部, 室長 … More 1996: 国立精神, 神経センター・神経研究所・代謝研究部, 室長 1996: National Institute of Neuroscience, Dept. of Neurochemistry, Section Chief, 神経センター神経研究所・代謝研究部, 室長 1996: 国立精神・神経センター, 代謝研究部, 室長 1995 – 1996: 国立精神神経センター, 神経研究所・代謝研究部, 室長 Less
Review Section/Research Field	Principal Investigator Neurochemistry/Neuropharmacology / Neurochemistry/Neuropharmacology Except Principal Investigator Orthopaedic surgery / Biological Sciences / Neurochemistry/Neuropharmacology / Cerebral neurosurgery
Keywords	Principal Investigator Rac / Iba1 / ミクログリア / 貧食 / 貪食 / アクチン / カルシウム / 活性化 / マクロファージ / activation … More / visualization / actin / phagocytosis / motility / microglia / フィンブリン / 可視化 / 遊走 / Phospholipase C / Macrophage / Phagocytosis / Ruffling / Actin / lba1 / Microglia / ホスフォリパーゼC / ラッフリング / カルシウム結合たんぱく質 / EFハンド / 主要組織適合遺伝子複合体 / 顔面神経切断 … More Except Principal Investigator microglia / ミクログリア / GFAP / P2Y12 / ATP / プラスミノーゲン / トランスジェニックマウス / マイクログリア / BINCs / プラスミノーゲンアクチベータ- / nestin / regenerative medicine / NG2 / transdifferentiation / oligodendrocyte / astrocyte / 神経組織再生 / 分化転換 / オリゴデンドロサイト / 神経系前駆細胞 / 神経細胞 / アストロサイト / NG2コンドロイチン硫酸ブロテオグリカン / NG2コンドロイチン硫酸プロテオグリカン / 細胞移植 / 脊髄損傷 / 多能性幹細胞 / R2Y receptor / G-protein couple / ATP receptor / Ruffling / Chemofcxis / シナプス / P2X7 / P2Y_<12> / Rac / ラッフリング運動 / P2Y_<12>受容体 / 遊走性 / 顔面神経線維 / P2Y受容体 / G蛋白共役務 / ATP受容体 / ラッフリング / 遊走能 / plasminogen activator / plasminogen / Cre / 脳損傷 / 脳虚血 / 損傷修復 / HSV-tk / アストログリオーシス / 骨髄 / マクロファージ / 幹細胞 / 脳梗塞 / NG2プロテオグリカン / Ibal / 顔面神経のアクソトミ- Less

トランスジェニックマウスを用いたマイクログリアによる脳損傷修復システムの解明
- Principal Investigator
  
  TANAKA Junya
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Ehime University
Development of novel therapeutic means to regenerating spinal cord injury using microglia/macrophages
- Principal Investigator
  
  TANAKA Junya
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  EHIME UNIVERSITY
Analysis of Iba1 and Rac in motility and phagocytosis of activated microgliaPrincipal Investigator
- Principal Investigator
  
  IMAI Yoshinori
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Ehime University
Analysis of microglia specific calcium-binding protein, lba1Principal Investigator
- Principal Investigator
  
  IMAI Yoshinori
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  National Canter of Neuroscience, NCNP
Regulation of synapse by microglia
- Principal Investigator
  
  KOHSAKA Shinichi
- Project Period (FY)
  1998 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (B)
- Review Section
  
  Biological Sciences
- Research Institution
  National Center of Neurology and Psychiatry
シナプスの再構築におけるミクログリア由来プロテアーゼの機能的役割に関する研究
- Principal Investigator
  
  NAKAJIMA Kazuyuki
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  National Center of Neurology and Psychiatry
活性化ミクログリアに特異的に発現する新規EFハンドたんぱく質の機能解析Principal Investigator
- Principal Investigator
  
  今井嘉紀
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  National Center of Neurology and Psychiatry
Significance of microglia derived plasmin-generating proteases in the nervous system
- Principal Investigator
  
  NAKAJIMA Kazuyuki
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  National Institute of Neuroscience

All 2007 2006 2004

All Journal Article

[Journal Article] Expression of CD200 by macrophage-like cells in ischemic core of rat brain after transient middle cerebral artery occlusion2007
- Author(s)
  H Matsumoto, Y Kumon, H Watanabe, T Ohnishi, H Takahashi, Y Imai, J Tanaka
- Journal Title
  
  Neuroscience Letters (In press)
- Data Source
  KAKENHI-PROJECT-17659448
[Journal Article] Antibodies to CD11b, CD68, and lectin label neutrophils rather than microglia in traumatic and ischemic brain lesions2007
- Author(s)
  H Matsumoto, Y Kumon, H Watanabe, T Ohnishi, M Shudou, C Ii, H Takahashi, Y Imai, J Tanaka
- Journal Title
  
  Journal of Neuroscience Research 85
  
  Pages: 994-1029
- Data Source
  KAKENHI-PROJECT-17659448
[Journal Article] Expression of heparanase in nestin-positive reactive astrocytes in ischemic lesions of rat brain after transient middle cerebral artery occlusion2007
- Author(s)
  H Takahashi, H Matsumoto, Y Kumon, T Ohnishi, C Freeman, Y Imai, J Tanaka
- Journal Title
  
  Neuroscience Letters (In press)
- Data Source
  KAKENHI-PROJECT-17659448
[Journal Article] NG2 proteoglycan-expressing microglia as multipotent neural progenitors in normal and pathologic brains2006
- Author(s)
  Akiko Yokoyma, Aiko Sakamoto, Kenji Kameda, Yoshinori Imai, Junya Tanaka
- Journal Title
  
  Glia 53
  
  Pages: 754-768
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390442
[Journal Article] NG2 proteoglycan-expressing microglia as multipotent neural progenitors in normal and pathologic brains2006
- Author(s)
  A Yokoyma, A Sakamoto, K Kameda, Y Imai, J Tanaka
- Journal Title
  
  Glia 53
  
  Pages: 754-768
- Data Source
  KAKENHI-PROJECT-17659448
[Journal Article] NG2 proteoglycan-expressing microglia as multipotent neural progenitors in normal and pathologic brains2006
- Author(s)
  Yokoyma A, Sakamoto A, Kameda K, Imai Y, Tanaka J
- Journal Title
  
  Glia (in press)
- Data Source
  KAKENHI-PROJECT-17659448
[Journal Article] NG2 proteoglycan-expressing microglia as multipotent neural progenitors in normal and pathologic brains2006
- Author(s)
  Yokoyama A, Sakamoto A, Kameda K, Imai Y, Tanaka J
- Journal Title
  
  Glia 53
  
  Pages: 754-768
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390442
[Journal Article] NG2 proteoglycan-expressing microglia as multipotent neural progenitors in normal and pathologic brains2006
- Author(s)
  Yokoyma A, Sakamoto A, Kameda K, Imai Y, Tanaka J
- Journal Title
  
  Glia (in press)
- Data Source
  KAKENHI-PROJECT-16390442
[Journal Article] Crystallization and preliminary X-ray crystallographic analysis of macrophage/microglia-sepcific calcium-binding protein Ibal.2004
- Author(s)
  Yamada, M., Imai, Y., Kohsaka, S., Kamitori S.
- Journal Title
  
  Acta Crystallogr.D Biol.Crystallogr. 60
  
  Pages: 569-571
- Data Source
  KAKENHI-PROJECT-16390442
[Journal Article] Human CD34+cells differentiate into microglia and express recombinant therapeutic protein.2004
- Author(s)
  Asheuer, M., Pflumo, F., Benhamida, S., Dubart-Kupperschmitt, A., Imai, Y., Aubourg, P., Cartier, N.Kupperschmitt, A., Imai,Y.
- Journal Title
  
  Proc.Natl.Acad.Sci.U.S.A. 101
  
  Pages: 3557-3562
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390442
[Journal Article] Human CD34+ cells differntiate into microglia and express recombinant therapeutic protein.2004
- Author(s)
  Asheuer, M., Pflumo, F., Benhamida, S., Dubart-Kupperschmitt, A., Imai, Y., Aubourg, P., Cartier, N.Kupperschmitt, A., Imai, Y., Aubourg, P., Cartier, N.
- Journal Title
  
  Proc.Natl.Acad.Sci.U.S.A. 101
  
  Pages: 3557-3562
- Data Source
  KAKENHI-PROJECT-16390442
[Journal Article] Human CD34+ cells differntiate into microglia and express recombinant therapeutic protein.2004
- Author(s)
  Asheuer, M., Pflumo, F., Benhamida, S, Dubart-Kupperschmitt, A., Imai, Y., Aubourg, P., Cartier, N.Kupperschmitt, A., Imai, Y.
- Journal Title
  
  Proc.Natl.Acad.Sci.U.S.A 101
  
  Pages: 3557-3562
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390442
[Journal Article] マイクログリア特異的たんぱく質Iba1と単量体Gたんぱく質Racの機能相関2004
- Author(s)
  今井嘉紀
- Journal Title
  
  愛媛医学 23
  
  Pages: 6-11
- Data Source
  KAKENHI-PROJECT-15500276
[Journal Article] Macrophage/microglia-specific protein Ibal binds to fimbrin and enhances actin-bundling activity of fimbrin.2004
- Author(s)
  Ohsawa, K., Imai, Y., Sasaki, Y., Kanazawa, H., Kohsaka, S.
- Journal Title
  
  J.Neurochem. 88
  
  Pages: 844-856
- Data Source
  KAKENHI-PROJECT-16390442
[Journal Article] Macrophage/microglia-specific protein lbal binds to fimbrin and enhances2004
- Author(s)
  Ohsawa, K., Imai, Y., Sasaki, Y., Kanazawa, H., Kohsaka, S.
- Journal Title
  
  J.Neurochem. 88
  
  Pages: 844-856
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390442
[Journal Article] Macrophage/microglia-specific protein Iba1 binds to fimbrin and enhances.2004
- Author(s)
  Ohsawa, K., Imai, Y., Sasaki, Y., Kanazawa, H., Kohsaka, S.
- Journal Title
  
  J.Neurochem. 88
  
  Pages: 844-856
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390442

1. NAKAJIMA Kazuyuki (50175494)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
2. TANAKA Junya (70217040)

# of Collaborated Projects: 2 results

# of Collaborated Products: 8 results
3. SUZUKI Shunji (60372728)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. KOHSAKA Shinichi (50112686)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. 高橋寿明 (20363228)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
6. AKAZAWA Chihiro (80291160)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. YAMAMOTO Haruyasu (10092446)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. OGATA Tadanori (30291503)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

IMAI Yoshinori 今井 嘉紀

Research Projects

Research Products

Co-Researchers

トランスジェニックマウスを用いたマイクログリアによる脳損傷修復システムの解明

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of novel therapeutic means to regenerating spinal cord injury using microglia/macrophages

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of Iba1 and Rac in motility and phagocytosis of activated microgliaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of microglia specific calcium-binding protein, lba1Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Regulation of synapse by microglia

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

シナプスの再構築におけるミクログリア由来プロテアーゼの機能的役割に関する研究

Principal Investigator

Project Period (FY)

Research Category

Research Institution

活性化ミクログリアに特異的に発現する新規EFハンドたんぱく質の機能解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Significance of microglia derived plasmin-generating proteases in the nervous system

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Expression of CD200 by macrophage-like cells in ischemic core of rat brain after transient middle cerebral artery occlusion2007

Author(s)

Journal Title

Data Source

[Journal Article] Antibodies to CD11b, CD68, and lectin label neutrophils rather than microglia in traumatic and ischemic brain lesions2007

Author(s)

Journal Title

Data Source

[Journal Article] Expression of heparanase in nestin-positive reactive astrocytes in ischemic lesions of rat brain after transient middle cerebral artery occlusion2007

Author(s)

Journal Title

Data Source

[Journal Article] NG2 proteoglycan-expressing microglia as multipotent neural progenitors in normal and pathologic brains2006

Author(s)

Journal Title

Description

Data Source

[Journal Article] NG2 proteoglycan-expressing microglia as multipotent neural progenitors in normal and pathologic brains2006

Author(s)

Journal Title

Data Source

[Journal Article] NG2 proteoglycan-expressing microglia as multipotent neural progenitors in normal and pathologic brains2006

Author(s)

Journal Title

Data Source

[Journal Article] NG2 proteoglycan-expressing microglia as multipotent neural progenitors in normal and pathologic brains2006

Author(s)

Journal Title

Description

IMAI Yoshinori 今井嘉紀