TSUBOUCHI HIDEO 坪内英生

… Alternative Names

坪内英生ツボウチヒデオ

TSUBOUCHI Hideo 坪内英生

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Researcher Number	20283822
Other IDs
External Links
Affiliation (Current)	2023: 東京工業大学, 科学技術創成研究院, 助教
Affiliation (based on the past Project Information) *help	2023: 東京工業大学, その他部局等, 助教 2017 – 2021: 東京工業大学, 科学技術創成研究院, 助教 2016: 基礎生物学研究所, 幹細胞生物学研究室, 特別協力研究員 1996 – 1998: 大阪大学, 大学院・理学研究科, 助手
Review Section/Research Field	Principal Investigator Basic Section 43010:Molecular biology-related / Molecular biology Except Principal Investigator Biological Sciences
Keywords	Principal Investigator 減数分裂 / 相同組換え / シナプトネマ複合体 / 染色体 / 細胞周期 / 染色体構造 / 出芽酵母 / 遺伝学 / DNA傷害修復 / RecA / 分裂酵母 / ＤＮＡ傷害修復 / ＲｅｃＡ … More Except Principal Investigator … More 出芽酵母 / 減数分裂期組換え / DNA二重鎖切断修復 / MRE11, RAD50 & XRS2遺伝子 / MER3遺伝子 / 非相同組換え / Rad51とRad52の相互作用 / RPA / MRE11,RAD50&XRS2遺伝子 / MRE11,RAD50 & XRS2遺伝子 / MRE2とスプライシング / RecA蛋白質のC末ドメイン / 二本鎖DNA結合"gateway"モデル / MRE2遺伝子の機能 / 減数分裂期特異的スプライシング / 交叉型組換え体形成MER3遺伝子 / Rad51-Rad52-RPA複合体 / Rad51とLim15の染色体上の局在 / テロメア領域の組換え / 遺伝的相同組喚え / 組喚えの開始機構 / クロマチン構造変化 / Rad50-Mre11-Xrs2複合体 / 減数分裂期二重鎖切断 / Rad52-RPA複合体 / DNA鎖移行反応 / Rad51,Lim15の染色体上の局在 / Rad51蛋白質 / Lim15(Dmc1)蛋白質 / 組換え開始機構 / 染色体構造 / DNA二重鎖切断 / RecA蛋白のDNA結合領域 / キメラRecA蛋白質 / non-homologous end joining / nuclease activity of Mre11 protein / RecA protein / strand-transfer activity of Rad51 / Rad52 protein / REP protein / initiation of meiotic recombination / processing from DSB ends Less

ナガニシア酵母で解き明かす相同組換え制御機構Principal Investigator
- Principal Investigator
  
  坪内英生
- Project Period (FY)
  2023 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 43010:Molecular biology-related
- Research Institution
  Tokyo Institute of Technology
分裂酵母の二つのRecAホモログRad51とDmc1の機能的相違Principal Investigator
- Principal Investigator
  
  坪内英生
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 43010:Molecular biology-related
- Research Institution
  Tokyo Institute of Technology
Understanding the mechanisms for ensuring timely destruction of the synaptonemal complex during meiosisPrincipal Investigator
- Principal Investigator
  
  TSUBOUCHI Hideo
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Molecular biology
- Research Institution
  Tokyo Institute of Technology
  National Institute for Basic Biology
Study on Genetic Recombination Systems in Eukaryotes
- Principal Investigator
  
  OGAWA Hideyuki
- Project Period (FY)
  1994 – 1998
- Research Category
  
  Grant-in-Aid for Specially Promoted Research
- Review Section
  
  Biological Sciences
- Research Institution
  Iwate College of Nursing
  Osaka University

All 2021 2020 2018 2017

All Journal Article Presentation

[Journal Article] A novel motif of Rad51 serves as an interaction hub for recombination auxiliary factors2021
- Author(s)
  Afshar Negar、Argunhan Bilge、Palihati Maierdan、Taniguchi Goki、Tsubouchi Hideo、Iwasaki Hiroshi
- Journal Title
  
  eLife
  
  Volume: 10
- DOI
  10.7554/elife.64131
- NAID
  120007124436
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02371, KAKENHI-PROJECT-20K15713
[Journal Article] A conserved Ctp1/CtIP C-terminal peptide stimulates Mre11 endonuclease activity2021
- Author(s)
  Zdravkovic Aleksandar、Daley James M.、Dutta Arijit、Niwa Tatsuya、Murayama Yasuto、Kanamaru Shuji、Ito Kentaro、Maki Takahisa、Argunhan Bilge、Takahashi Masayuki、Tsubouchi Hideo、Sung Patrick、Iwasaki Hiroshi
- Journal Title
  
  Proceedings of the National Academy of Sciences USA
  
  Volume: 118 Pages: 1-7
- DOI
  10.1073/pnas.2016287118
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02371, KAKENHI-PROJECT-19H03160, KAKENHI-PROJECT-19K16039, KAKENHI-PROJECT-20K15713, KAKENHI-PROJECT-18K05314, KAKENHI-PROJECT-21K05268
[Journal Article] Two Auxiliary Factors Promote Dmc1-Driven DNA Strand Exchange via Stepwise Mechanisms2020
- Author(s)
  Hideo Tsubouchi1, Bilge Argunhan, Kentaro Ito, Masayuki Takahashi, Hiroshi Iwasaki
- Journal Title
  
  PNAS
  
  Volume: -
- NAID
  120007117440
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H02371
[Journal Article] Draft genome sequence of Naganishia liquefaciens strain N6, isolated from the Japan Trench.2020
- Author(s)
  Han Yong-Woon、Kajitani Rei、Morimoto Hiroya、Palihati Maierdan、Kurokawa Yumiko、Ryusui Rie、Argunhan Bilge、Tsubouchi Hideo、Abe Fumiyoshi、Kajiwara Susumu、Iwasaki Hiroshi、Itoh Takehiko
- Journal Title
  
  Microbiol Resour. Announc.
  
  Volume: 9
- DOI
  10.1128/mra.00827-20
- NAID
  120007124437
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02371, KAKENHI-PROJECT-18K05397, KAKENHI-PROJECT-18H03985, KAKENHI-PROJECT-19H03206, KAKENHI-PROJECT-20K15713
[Journal Article] Cooperative interactions facilitate stimulation of Rad51 by the Swi5-Sfr1 auxiliary factor complex2020
- Author(s)
  Argunhan B, Sakakura M, Afshar N, Kurihara M, Ito K, Maki T, Kanamaru S, Murayama Y, Tsubouchi H, Takahashi M, Takahashi H, Iwasaki H.
- Journal Title
  
  eLife
  
  Volume: 9
- DOI
  10.7554/elife.52566
- NAID
  120007117502
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K05314, KAKENHI-PROJECT-19K16039, KAKENHI-PLANNED-15H05974, KAKENHI-PUBLICLY-18H04626, KAKENHI-PLANNED-18H05426, KAKENHI-PROJECT-18H03985, KAKENHI-PROJECT-18H02393, KAKENHI-PROJECT-19H03160, KAKENHI-PROJECT-17K15061, KAKENHI-PROJECT-18H02371, KAKENHI-PROJECT-20K15713
[Journal Article] Polo is not solo in meiosis2018
- Author(s)
  Argunhan Bilge、Tsubouchi Tomomi、Tsubouchi Hideo
- Journal Title
  
  Cell Cycle
  
  Volume: (17) 3 Pages: 1-2
- DOI
  10.1080/15384101.2017.1411435
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H07422
[Journal Article] Fundamental cell cycle kinases collaborate to ensure timely destruction of the synaptonemal complex during meiosis2017
- Author(s)
  Argunhan B, Leung WK, Afshar N, Terentyev Y, Subramanian VV, Murayama Y, Hochwagen A, Iwasaki H, Tsubouchi T, Tsubouchi H.
- Journal Title
  
  The EMBO Journal
  
  Volume: 36 Pages: 2488-2509
- DOI
  10.15252/embj.201695895
- NAID
  120007117670
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-INTERNATIONAL-15K21761, KAKENHI-PUBLICLY-16H01404, KAKENHI-PROJECT-16H06160, KAKENHI-PROJECT-16H07422, KAKENHI-PLANNED-15H05974
[Journal Article] Exiting prophase I: no clear boundary2017
- Author(s)
  Tsubouchi Hideo、Argunhan Bilge、Tsubouchi Tomomi
- Journal Title
  
  Current Genetics
  
  Volume: 64 Pages: 423-427
- DOI
  10.1007/s00294-017-0771-y
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H07422
[Presentation] クリプトコッカス酵母をモデルとした相同組換え研究の新展開2020
- Author(s)
  坪内英生
- Organizer
  日本遺伝学会第91回大会
- Invited
- Data Source
  KAKENHI-PROJECT-18H02371
[Presentation] BRCA2を持つ担子菌Naganishia liquefaciens(ナガニシア酵母)を用いた相同組換え機構の解析2020
- Author(s)
  坪内英生、Palihati Maierdan、Bakenova Omirgul、青木陸登、今井健人、梶谷嶺、韓龍雲、伊藤武彦、岩﨑博史
- Organizer
  酵母遺伝学フォーラム　第 53 回研究報告会
- Data Source
  KAKENHI-PROJECT-18H02371
[Presentation] 減数分裂期特異的に形成される高次染色体構造を解消するメカニズム2017
- Author(s)
  坪内英生
- Organizer
  第24回DNA複製・組換え・修復ワークショップ
- Data Source
  KAKENHI-PROJECT-16H07422

1. OGAWA Hideyuki (70028207)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. SHINOHARA Akira (00252578)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. SHIBATA Takehiko (70087550)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. OGAWA Tomoko (80028208)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. ARGUNHAN Bilge (30792759)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
6. TSUBOUCHI Tomomi (70754505)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
7. ITOH Takehiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. MURAYAMA Yasuto

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
9. 阿部文快

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 岩崎博史

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
11. 金丸周司

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
12. 伊藤健太郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
13. 高橋栄夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

TSUBOUCHI HIDEO 坪内 英生

坪内 英生 ツボウチ ヒデオ

TSUBOUCHI Hideo 坪内 英生

Research Projects

Research Products

Co-Researchers

ナガニシア酵母で解き明かす相同組換え制御機構Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

分裂酵母の二つのRecAホモログRad51とDmc1の機能的相違Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Understanding the mechanisms for ensuring timely destruction of the synaptonemal complex during meiosisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study on Genetic Recombination Systems in Eukaryotes

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] A novel motif of Rad51 serves as an interaction hub for recombination auxiliary factors2021

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] A conserved Ctp1/CtIP C-terminal peptide stimulates Mre11 endonuclease activity2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Two Auxiliary Factors Promote Dmc1-Driven DNA Strand Exchange via Stepwise Mechanisms2020

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Draft genome sequence of Naganishia liquefaciens strain N6, isolated from the Japan Trench.2020

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Cooperative interactions facilitate stimulation of Rad51 by the Swi5-Sfr1 auxiliary factor complex2020

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Polo is not solo in meiosis2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Fundamental cell cycle kinases collaborate to ensure timely destruction of the synaptonemal complex during meiosis2017

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Exiting prophase I: no clear boundary2017

Author(s)

Journal Title

DOI

Data Source

[Presentation] クリプトコッカス酵母をモデルとした相同組換え研究の新展開2020

Author(s)

Organizer

Data Source

[Presentation] BRCA2を持つ担子菌Naganishia liquefaciens(ナガニシア酵母)を用い た相同組換え機構の解析2020

Author(s)

TSUBOUCHI HIDEO 坪内英生

坪内英生ツボウチヒデオ

TSUBOUCHI Hideo 坪内英生

[Presentation] BRCA2を持つ担子菌Naganishia liquefaciens(ナガニシア酵母)を用いた相同組換え機構の解析2020