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KINOSHITA Hiroshi  木下 浩

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KINOSHIMA Hiroshi  木下 浩

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Researcher Number 20294035
Other IDs
Affiliation (based on the past Project Information) *help 2014 – 2015: 大阪大学, 生物工学国際交流センター, 助手
2009 – 2015: 大阪大学, 生物工学国際交流センター, 助教
2003 – 2006: 大阪大学, 生物工学国際交流センター, 助手
1998 – 2000: 大阪大学, 大学院・工学研究科, 助手
Review Section/Research Field
Principal Investigator
Biofunction/Bioprocess
Except Principal Investigator
Living organism molecular science / Applied microbiology / 応用微生物学・応用生物化学 / Functional biochemistry / Biofunction/Bioprocess
Keywords
Principal Investigator
Aspergillus / 二次代謝物質 / 麹菌 / Aspergillus oryzae / 糸状菌 / 異種生産系 / 生合成遺伝子クラスター / Cre-loxP / 生理活性物質
Except Principal Investigator
放線菌 … More / 二次代謝 / Streptomyces / 生理活性物質 / 抗生物質生産 / Virginiae butanolide / オートレギュレーター / Streptomyces virginiae / 信号伝達物質 / 信号伝達 / 休眠遺伝子 / 糸状菌 / Signaling molecules / Secondary metabolism / 破壊珠 / virginiamycin生産 / 破壊株 / レセプター / ブチロラクトンオートレギュレーター / γ-butyrolactone autoregulator / structure determination / Streptomyces coelicolor / Streptomyces hormones / リセプター / antibiotic production / 2D electrophoresis / autoregulator / 2次元電気泳動 / 二次元電気泳動 / 二次代謝誘導 / 二次代謝覚醒 / ホルモン / 覚醒物質 / 休眠生合成系 / 低分子リガンド / 未同定リガンド / オーファンレセプター / TetR型制御因子 / オーファンリセプター / 未知リガンド / オーファン受容体 / クラスター特異的転写因子 / 生合成遺伝子クラスター / 転写活性化因子 / 生合成遺伝子 / 生合成制御 / 生体触媒工学 / 昆虫病原性糸状菌 Less
  • Research Projects

    (8 results)
  • Research Products

    (42 results)
  • Co-Researchers

    (7 People)
  •  Orphan receptors and their ligands in Streptomyces secondary metabolism

    • Principal Investigator
      Nihira Takuya
    • Project Period (FY)
      2012 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Living organism molecular science
    • Research Institution
      Osaka University
  •  Application of biosynthetic genes for fungal secondary metabolites by using Cre-loxp systemPrincipal Investigator

    • Principal Investigator
      KINOSHITA Hiroshi
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Biofunction/Bioprocess
    • Research Institution
      Osaka University
  •  Autoregulator addition strategy to awakening cryptic biosynthetic genes

    • Principal Investigator
      NIHIRA Takuya
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Living organism molecular science
    • Research Institution
      Osaka University
  •  Macrocyclic antibiotics production-platform through biosynthetic engineering

    • Principal Investigator
      NIHIRA Takuya
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Biofunction/Bioprocess
    • Research Institution
      Osaka University
  •  休眠遺伝子の強制発現システムによる糸状菌からの新規生理活性物質の探索

    • Principal Investigator
      NIHIRA Takuya
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Applied microbiology
    • Research Institution
      Osaka University
  •  Clarification of mechanism for antibiotic production regulated by Streptomyces signaling molecules.

    • Principal Investigator
      NIHIRA Takuya
    • Project Period (FY)
      2003 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Applied microbiology
    • Research Institution
      Osaka University
  •  Proteome analysis on the regulation mechanism of antibiotic production

    • Principal Investigator
      NIHIRA Takuya
    • Project Period (FY)
      1998 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (B).
    • Research Field
      Functional biochemistry
    • Research Institution
      Osaka University
  •  Streptomyces hormones and corresponding receptors in antibiotic producing industrial Streptomyces species

    • Principal Investigator
      YAMADA Yasuhiro
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      応用微生物学・応用生物化学
    • Research Institution
      Osaka University

All 2014 2012 2011 2010 2009 2006 2005 2004 Other

All Journal Article Presentation Patent

  • [Journal Article] Efficient and versatile transformation systems in entomopathogenic fungus Lecanicillium species2014

    • Author(s)
      Kei-ichi Ishidoh, Hiroshi Kinoshita, Fumio Ihara, Takuya Nihira
    • Journal Title

      Curr Genet

      Volume: 60 Issue: 2 Pages: 99-108

    • DOI

      10.1007/s00294-013-0399-5

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24560960
  • [Journal Article] Identification and characterization of Penicillium citrinum VeA and LaeA as global regulators for ML-236B production2012

    • Author(s)
      Baba, S., Kinoshita, H., Nihira, T
    • Journal Title

      Current Genetics

      Volume: 58 Issue: 1 Pages: 1-11

    • DOI

      10.1007/s00294-011-0359-x

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21360404
  • [Journal Article] Heterologous expression system in Aspergillus oryzae for fungal biosynthetic gene clusters of secondary metabolites2011

    • Author(s)
      Sakai, K., Kinoshita, H., and Nihira, T.
    • Journal Title

      Appl. Microbiol. Biotechnolo.

      Volume: 93

    • Data Source
      KAKENHI-PROJECT-21360404
  • [Journal Article] Xylaropyrone, a new γ-pyrone from the endophytic fungus Xylaria feejeensis MU182011

    • Author(s)
      Siriwach, R., Kinoshita, H., Kitani, S., Igarashi, Y., Pansuksan, K., Panbangred, W., Nihira, T.
    • Journal Title

      J Antibiotic

      Volume: 64(2) Pages: 217-219

    • NAID

      10030638198

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21360404
  • [Journal Article] Heterologous expression system in Aspergillus oryzae for fungal biosynthetic gene clusters of secondary metabolites2011

    • Author(s)
      Sakai, K., Kinoshita, H., Nihira, T
    • Journal Title

      Appl Microbiol Biotechnol

      Volume: 93 Issue: 5 Pages: 2011-2022

    • DOI

      10.1007/s00253-011-3657-9

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21360404
  • [Journal Article] Identification and characterization of Penicillium citrinum VeA and LaeA as global regulators for ML-236B production2011

    • Author(s)
      Baba, S., Kinoshita, H. and Nihira, T.
    • Journal Title

      Current Genetics

      Volume: 58 Pages: 1-11

    • Data Source
      KAKENHI-PROJECT-21360404
  • [Journal Article] Geranylgeranyl diphosphate synthase genes in entomopathogenic fungi2010

    • Author(s)
      Singkaravanit, S., Kinoshita, H., Ihara, F., Nihira, T
    • Journal Title

      Appl. Microbiol. Biotechnol. In press

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21360404
  • [Journal Article] Characterization of varM encoding type II ABC transporter in Streptomyces virginiae, a virginiamycin M_1 producer2010

    • Author(s)
      Kitani, S., Yamauchi, T., Fukushima, E., Lee, C. K, Fitria Ningsih, Kinoshita, H., and Nihira, T.
    • Journal Title

      Actinomycetologica

      Volume: (In press)

    • NAID

      10027123055

    • Data Source
      KAKENHI-PROJECT-21360404
  • [Journal Article] Ophiosetin, a New Tetramic Acid Derivative from the Mycopathogenic Fungus Elaphocordyceps ophioglossoides2010

    • Author(s)
      Sastia, P. Putri, Kinoshita, H., Ihara, F., Igarashi, Y. and Nihira, T.
    • Journal Title

      J. Antibiotics Nature

      Volume: 63 Pages: 195-198

    • NAID

      10030708189

    • Data Source
      KAKENHI-PROJECT-21360404
  • [Journal Article] Characterization of varM encoding type II ABC transporter in Stre ptomyces virginiae, a virginiamycin M_1 producer.2010

    • Author(s)
      Kitani, S., Yamauchi, T., Fukushima, E., Lee, C.K, Fitria Ningsih, Kinoshita, H., Nihira, T.
    • Journal Title

      Actinomycetologica

      Volume: 24 Pages: 51-57

    • NAID

      10027123055

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21360404
  • [Journal Article] Geranylgeranyl diphosphate synthase genes in entomopathogenic fungi2010

    • Author(s)
      Singkaravanit, S., Kinoshita, H., Ihara, F. and Nihira, T.
    • Journal Title

      Appl. Microbiol. Biotechnol.

      Volume: 85 Pages: 1463-1472

    • Data Source
      KAKENHI-PROJECT-21360404
  • [Journal Article] Xylaropyrone, a newγ-pyrone from the endophytic fungus Xylaria feejeensis MU182010

    • Author(s)
      Siriwach, R., Kinoshita, H., Kitani, S., Igarashi, Y., Pansuksan, K., Panbangred, W., Nihira, T.
    • Journal Title

      Journal of Antibiotics Nature

      Volume: 64 Pages: 217-219

    • NAID

      10030638198

    • Data Source
      KAKENHI-PROJECT-21360404
  • [Journal Article] Cloning and functional analysis of the second geranylgeranyl diphosphate synthase gene influeicing helvolic acid biosynthesis in Metarhizium anisopliae2010

    • Author(s)
      Singkaravanit, S., Kinoshita, H., Ihara, F., and Nihira, T.
    • Journal Title

      Appl. Microbiol. Biotechnol

      Volume: 87 Pages: 1077-1088

    • Data Source
      KAKENHI-PROJECT-21360404
  • [Journal Article] Identification of mokB involved in monacolin K biosynthesis in Monascus pilosus2009

    • Author(s)
      Sakai, K., Kinoshita, H. and Nihira, T.
    • Journal Title

      Biotechnol. Lett.

      Volume: 31 Pages: 1911-6

    • Data Source
      KAKENHI-PROJECT-21360404
  • [Journal Article] MlcR, a zinc cluster activator protein, is able to bind to a single(A/ T) CGG site of cognate asymmetric motifs in the ML-236B(compactin) biosynthetic gene cluster2009

    • Author(s)
      Baba S, Kinoshita H, Hosobuchi M, and Nihira T.
    • Journal Title

      Mol Genet Genomics

      Volume: 281 Pages: 627-34

    • Data Source
      KAKENHI-PROJECT-21360404
  • [Journal Article] Farinomalein, a Maleimide-bearing Compound from the Entomopathogenic Fungus Paecilomyces farinosus2009

    • Author(s)
      Sastia P. Putri, Kinoshita, H., Ihara, F., Igarashi, Y. and Nihira, T.
    • Journal Title

      J. Natural Products

      Volume: 72 Pages: 1544-6

    • Data Source
      KAKENHI-PROJECT-21360404
  • [Journal Article] MlcR, a zinc cluster activator protein, is able to bind to a single (A/T)CGG site of cognate asymmetric motifs in the ML-236B (compactin) biosynthetic gene cluster.2009

    • Author(s)
      Baba S, Kinoshita H, Hosobuchi M, Nihira T.
    • Journal Title

      Mol Genet Genomics 281

      Pages: 627-634

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21360404
  • [Journal Article] Identification of mokB involved in monacolin K biosynthesis in Monascus pilosus2009

    • Author(s)
      Sakai, K., Kinoshita, H., Nihira, T.
    • Journal Title

      Biotechnol. Lett. 31

      Pages: 1911-1916

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21360404
  • [Journal Article] Development of transformation system in Monascus purureus using an automonous replication vector with aureobasidin A resistance gene.2006

    • Author(s)
      Shimizu, T., Kinoshita, H., Nihira, T.
    • Journal Title

      Biotechnol Lett. 28

      Pages: 115-120

    • Data Source
      KAKENHI-PROJECT-17658042
  • [Journal Article] Cultivation of Entomopathogenic Fungi for the Search of Antibacterial Compounds2005

    • Author(s)
      Si-Young Lee, Ikuo Nakajima, Hiroshi Kinoshita, Fumio Ihara, Takuya Nihira
    • Journal Title

      Mycopathology 160

      Pages: 321-325

    • Data Source
      KAKENHI-PROJECT-17658042
  • [Journal Article] Cloning and functional analysis by gene disruption of a gene encoding a γ-butyrolactone autoregulator receptor from Kitasatospora setae.2004

    • Author(s)
      Choi, S-U., Lee, C-K., Hwang, Y-I., Kinoshita, H., Nihira, T.
    • Journal Title

      J.Bacteriol. 186

      Pages: 3423-3430

    • Data Source
      KAKENHI-PROJECT-15380063
  • [Journal Article] Intergeneric conjugal transfer of plasmid DNA from Escherichia coil to Kitasatospora setae, a bafilomycin B(1) producer.2004

    • Author(s)
      Choi, S-U., Lee, C-K., Hwang, Y-I., Kinoshita, H., Nihira, T.
    • Journal Title

      Arch.Microbiol. 184

      Pages: 294-298

    • Data Source
      KAKENHI-PROJECT-15380063
  • [Journal Article] Cloning and characterization of a gene encoding the γ-butyrolactone autoregulator receptor from Streptomyces clavuligerus.2004

    • Author(s)
      Kim, H-S., Lee, Y-J., Lee, C-K., Choi, S-U., Yeo, S-H., Hwang, Y-L., Yu, T-S., Kinoshita, H., Nihira, T.
    • Journal Title

      Arch.Microbiol. (In press)

    • Data Source
      KAKENHI-PROJECT-15380063
  • [Journal Article] Identification and in vivo functional analysis by gene disruption of ctnR, a positive regulator of citrinin biosynthesis in Monascus purpurea.

    • Author(s)
      Shimizu, T., Kinoshita, H., Nihira, T.
    • Journal Title

      Appl. Environ. Microbiol (submitted)

    • Data Source
      KAKENHI-PROJECT-17658042
  • [Patent] 紅麹菌由来生理活性物質生産誘導因子の同定およびその応用2006

    • Inventor(s)
      仁平卓也, 木下浩
    • Industrial Property Rights Holder
      大阪大学
    • Industrial Property Number
      2006-229434
    • Filing Date
      2006-08-25
    • Data Source
      KAKENHI-PROJECT-17658042
  • [Presentation] Characterization of argB gene from Lecanicillium sp. HF6272012

    • Author(s)
      Nguyen Nhu Ha Vy, Keiichi Ishido, Hiroshi Kinoshita, Takuya Nihira
    • Organizer
      第64回生物工学会大会
    • Place of Presentation
      神戸国際会議場
    • Data Source
      KAKENHI-PROJECT-24560960
  • [Presentation] 昆虫病原性糸状菌Lecanicillium sp.における宿主ベクター系の構築およびku80遺伝子の破壊2011

    • Author(s)
      石堂圭一, 木下浩, 井原史雄, 仁平卓也
    • Organizer
      日本生物工学会2011年度大会
    • Place of Presentation
      東京
    • Year and Date
      2011-09-27
    • Data Source
      KAKENHI-PROJECT-21360404
  • [Presentation] laeA異種発現によるCordyceps militarisの二次代謝活性化2011

    • Author(s)
      木下浩, Rina Rachmawati, 井原史雄, 仁平卓也
    • Organizer
      第11回糸状菌分子生物学コンファレンス
    • Place of Presentation
      東京
    • Year and Date
      2011-11-17
    • Data Source
      KAKENHI-PROJECT-21360404
  • [Presentation] 昆虫病原性糸状菌Lecanicillium sp.における宿主ベクター系の構築2011

    • Author(s)
      石堂圭一, 木下浩, 井原史雄, 仁平卓也
    • Organizer
      日本農芸化学会2011年度大会
    • Place of Presentation
      京都
    • Year and Date
      2011-03-26
    • Data Source
      KAKENHI-PROJECT-21360404
  • [Presentation] ポスターNew chromone derivative produced by endophytic fungus Daldinia sp. MU41 isolated from Thai medicinal plant Tinospora crispa2010

    • Author(s)
      Ratklao SIRIWACH, Hiroshi KINOSHITA, Kanoktip PANSUKSAN, Watanalai PANBANGRED, Yasuhiro IGARASHI, Takuya NIHIRA
    • Organizer
      日本生物工学会2010年度大会
    • Place of Presentation
      宮崎
    • Year and Date
      2010-10-28
    • Data Source
      KAKENHI-PROJECT-21360404
  • [Presentation] 麹菌Aspergillus oryzaeを宿主とするテレキノンA異種生産系の構築2010

    • Author(s)
      木下浩, 酒井香奈絵, 仁平卓也
    • Organizer
      第10回糸状菌分子生物学コンファレンス
    • Place of Presentation
      広島
    • Year and Date
      2010-11-19
    • Data Source
      KAKENHI-PROJECT-21360404
  • [Presentation] Isolation of a new tetramic acid derivative, ophiosetin from the entomopathogenic fungus Elaphocordyceps ophioglossoides by chemical screening.2010

    • Author(s)
      Prama PUTRI Sastia, Hiroshi KINOSHITA, Fumio IHARA, Yasuhiro IGARASHI, Takuya NIHIRA
    • Organizer
      日本農芸化学会2010年度大会
    • Place of Presentation
      東京
    • Year and Date
      2010-03-28
    • Data Source
      KAKENHI-PROJECT-21360404
  • [Presentation] Identification of a novel bioactive compound produced by endophytic fungi isolated from Thai medicinal plant.2010

    • Author(s)
      Ratklao SIRIWACH, Hiroshi KINOSHITA, Kanoktip PANSUKSAN, Watanalai PANBANGRED, Yasuhiro IGARASHI, Takuya NIHIRA
    • Organizer
      日本農芸化学会2010年度大会
    • Place of Presentation
      東京
    • Year and Date
      2010-03-28
    • Data Source
      KAKENHI-PROJECT-21360404
  • [Presentation] 昆虫病原性糸状菌Verticillium lecaniiが生産する環状リポペプチド新規類縁体の単離及び構造解析2010

    • Author(s)
      石堂圭一、五十嵐康弘、木下浩、井原史雄、仁平卓也
    • Organizer
      日本農芸化学会2010年度大会
    • Place of Presentation
      東京
    • Year and Date
      2010-03-28
    • Data Source
      KAKENHI-PROJECT-21360404
  • [Presentation] Metarhizium anisopliaeにおけるヘルボル酸生合成に必須なゲラニルゲラニル二リン酸生合成酵素遺伝子の同定2010

    • Author(s)
      木下浩、Singkarabanit Suthitar、井原史雄、仁平卓也
    • Organizer
      日本農芸化学会2010年度大会
    • Place of Presentation
      東京
    • Year and Date
      2010-03-29
    • Data Source
      KAKENHI-PROJECT-21360404
  • [Presentation] 「伝統的発酵微生物の新しい利用展開」糸状菌休眠遺伝子群の有効利用2010

    • Author(s)
      仁平卓也, 木下浩
    • Organizer
      日本生物工学会2010年度大会
    • Place of Presentation
      宮崎
    • Year and Date
      2010-10-27
    • Data Source
      KAKENHI-PROJECT-21360404
  • [Presentation] ポスターAntimicrobial and antioomycete activities of the novel antibiotic farinomalein2010

    • Author(s)
      Sastia PRAMA PUTRI, Hiroshi KINOSHITA, Masayasu KATO, Takuya NIHIRA
    • Organizer
      日本生物工学会2010年度大会
    • Place of Presentation
      宮崎
    • Year and Date
      2010-10-28
    • Data Source
      KAKENHI-PROJECT-21360404
  • [Presentation] Isolation of novel bioactive compounds from entomopathogenic fungi by chemical screening : Sastia Prama PUTRI2009

    • Author(s)
      Hiroshi KINOSHITA, F IHARA, Yasuhiro IGARASHI, Takuya NIHIRA
    • Organizer
      第9回糸状菌分子生物学コンファレンス
    • Place of Presentation
      東京
    • Year and Date
      2009-11-18
    • Data Source
      KAKENHI-PROJECT-21360404
  • [Presentation] Monacolin K生合成におけるZn(II) 2Cys6タイプ転写制御因子MokHの機能解析2009

    • Author(s)
      酒井香奈江, 木下浩, 仁平卓也
    • Organizer
      第9回糸状菌分子生物学コンファレンス
    • Place of Presentation
      東京
    • Year and Date
      2009-11-19
    • Data Source
      KAKENHI-PROJECT-21360404
  • [Presentation] Utilization of entomopathogenic fungi for the control of plant pathogenic oomycetes2009

    • Author(s)
      Sastia Prama Putri, Hiroshi Kinoshita, Fumio Ihara, Yasuhiro Igarashi, Takuya Nihira
    • Organizer
      42nd annual meeting of the Society of Invertebrate Pathology(SIP)
    • Place of Presentation
      Utha
    • Year and Date
      2009-08-19
    • Data Source
      KAKENHI-PROJECT-21360404
  • [Presentation] 遺伝子工学的手法による昆虫病原性糸状菌の二次代謝活性化2009

    • Author(s)
      森椙愛子, 小川孝, 木下浩, 仁平卓也
    • Organizer
      第61回日本生物工学会大会
    • Place of Presentation
      名古屋
    • Year and Date
      2009-09-24
    • Data Source
      KAKENHI-PROJECT-21360404
  • [Presentation] 昆虫病原性糸状菌ゲノムへのランダム遺伝子挿入による新規二次代謝物質の取得

    • Author(s)
      佐藤巧規、木下 浩、井原史雄、仁平卓也
    • Organizer
      日本農芸化学会
    • Place of Presentation
      岡山大学
    • Year and Date
      2015-03-27 – 2015-03-29
    • Data Source
      KAKENHI-PROJECT-24560960
  • 1.  NIHIRA Takuya (70144441)
    # of Collaborated Projects: 7 results
    # of Collaborated Products: 38 results
  • 2.  KITANI Shigeru (10379117)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 4 results
  • 3.  YAMADA Yasuhiro (00011891)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 4.  SEKI Tatsuji (50029245)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  KAWASAKI Hiroko (30251482)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  五十嵐 康弘 (20285159)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  SAWADA Hidekazu
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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※ この処理は、研究者本人だけが実行できます。

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