Miyoshi Keiko 三好圭子

… Alternative Names

MIYOSHI Keiko 三好圭子

三好圭子ミヨシケイコ

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Researcher Number	20304537
Other IDs
Affiliation (Current)	2025: 徳島大学, 大学院医歯薬学研究部(歯学域), 准教授
Affiliation (based on the past Project Information) *help	2025: 徳島大学, 大学院医歯薬学研究部(歯学域), 准教授 2018 – 2023: 徳島大学, 大学院医歯薬学研究部(歯学域), 准教授 2016 – 2017: 徳島大学, 大学院医歯薬学研究部(歯学系), 准教授 2015: 徳島大学, 大学院医歯薬学研究部, 准教授 2012 – 2014: 徳島大学, ヘルスバイオサイエンス研究部, 講師 … More 2009 – 2011: The University of Tokushima, 大学院・ヘルスバイオサイエンス研究部, 講師 2007: The University of Tokushima, 大学ヘルスバイオサイエンス研究部, 講師 2006: 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 講師 2005: 徳島大学, 大学院ヘルスバイオサイエンス研究部, 助手 2004: 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 助手 2003: 徳島大学, 歯学部, 助手 Less
Review Section/Research Field	Principal Investigator Functional basic dentistry / Basic Section 57010:Oral biological science-related / Basic Section 57020:Oral pathobiological science-related Except Principal Investigator Basic Section 57060:Surgical dentistry-related / Basic Section 57050:Prosthodontics-related / Prosthodontics/ Dental materials science and / Conservative dentistry
Keywords	Principal Investigator ゴーシェ病 / 口腔粘膜線維芽細胞 / 細胞内局在 / SiRNA / マイクロアレイ / 転写因子 / モディファイヤー / 翻訳制御機構 / RNAエピジェネティクス / 遺伝子発現調節機構 … More / 遺伝子構造 / 遺伝子翻訳制御機構 / 遺伝子発現制御機構 / GBA / Cap非依存性IRES依存性翻訳機構 / GBA遺伝子発現調節機構 / エピトランスクリプトーム / RNA修飾 / GCase / 糖脂質分解酵素 / ハイスループット酵素活性測定系 / GCase結合タンパク質 / in cell 酵素活性解析 / SiRNA スクリーニング / GCase活性調節タンパク質 / データマイニング / エクソーム解析 / intact cell GCase assay / モディファイヤー検索 / exome解析 / 疾患特異的口腔粘膜由来iPS細胞 / 口腔粘膜線維芽細胞の特性 / 疾患特異的iPS細胞 / 遺伝学 / 核移行シグナル / Sp6 / 相互作用分子 / 活性-構造相関 / 標的配列 / 転写活性 / 機能ドメイン / SP6 / 転写調節 / 分化制御 / 組織特異性 / アメロゲニン遺伝子 / アメロゲニン / 分化誘導 / SRE-G5 / 器官培養 / MAPK / フォリスタチン / プロモーター解析 / エナメル質形成不全症 / エナメル芽細胞 / 組織特異的発現 / マウス / 最終分化 / DNA array / Protein / 機能的分化 / 顎下腺 … More Except Principal Investigator miRNA / microRNA / マイクロRNA / 金属アレルギー / 発達 / 口腔乾燥 / 器官培養 / 遺伝子 / 再生 / 唾液腺 / バイオマーカー / アレルギー性接触皮膚炎 / アレルギー / 歯科補綴学一般 / ピアス / チタン / パッチテスト / 細胞外基質 / 分化 / クローン / 幹細胞 / 再生医学 Less

RNA修飾解析により紐解くゴーシェ病の新規修飾因子の特定Principal Investigator
- Principal Investigator
  
  三好圭子
- Project Period (FY)
  2025 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 57020:Oral pathobiological science-related
- Research Institution
  The University of Tokushima
RNA修飾による糖脂質分解酵素活性制御機構の解明とゴーシェ病克服への挑戦Principal Investigator
- Principal Investigator
  
  三好圭子
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57010:Oral biological science-related
- Research Institution
  The University of Tokushima
The identification of genes involved in the maintenance and regeneration of salivary gland stem / progenitor cells and application to new xerostomia treatment
- Principal Investigator
  
  山村佳子
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Juntendo University
  The University of Tokushima
Establishment of the new diagnosis biomarkers for metal allergy by analyzing peripheral blood miRNA expression
- Principal Investigator
  
  HOSOKI Maki
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57050:Prosthodontics-related
- Research Institution
  The University of Tokushima
Explore of the GBA translation regulatory mechanism by RNA epigenetics: To find the therapeutic targets for Gaucher diseasePrincipal Investigator
- Principal Investigator
  
  MIYOSHI Keiko
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57010:Oral biological science-related
- Research Institution
  The University of Tokushima
Metal allergy; What is the difference between sensitization and onset? -Identification of specific genes-
- Principal Investigator
  
  HOSOKI Maki
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Prosthodontics/ Dental materials science and
- Research Institution
  The University of Tokushima
Characterization of Gaucher disease by new gene mutation using patient-derived oral mucosa fibroblastsPrincipal Investigator
- Principal Investigator
  
  MIYOSHI Keiko
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional basic dentistry
- Research Institution
  The University of Tokushima
Establishment of disease model system using patient-derived oral mucosa fibroblast-iPSCs and development of new therapyPrincipal Investigator
- Principal Investigator
  
  MIYOSHI Keiko
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional basic dentistry
- Research Institution
  The University of Tokushima
Relationship between transcriptional activity and structure of tooth specific transcription factor Sp6 and identification of its interaction moleculesPrincipal Investigator
- Principal Investigator
  
  MIYOSHI Keiko
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Functional basic dentistry
- Research Institution
  The University of Tokushima
歯原性上皮細胞および歯髄細胞を用いた歯質再建のための細胞療法の開発
- Principal Investigator
  
  松尾敬志
- Project Period (FY)
  2005
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Conservative dentistry
- Research Institution
  The University of Tokushima
エナメル芽細胞の分化、成熟、維持機構の解明Principal Investigator
- Principal Investigator
  
  三好圭子
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Functional basic dentistry
- Research Institution
  The University of Tokushima
口腔乾燥症の治療に向けた唾液腺腺房細胞の分化メカニズムの解明Principal Investigator
- Principal Investigator
  
  三好圭子
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Functional basic dentistry
- Research Institution
  The University of Tokushima

All 2022 2017 2016 2015 2014 2012 2011 2010 Other

All Journal Article Presentation

[Journal Article] miR 155 5p can be involved in acquisition of osseointegration on titanium surface2022
- Author(s)
  Yoshiko Yamamura, Keiko Miyoshi, Yasuhiro Mouri, Yasusei Kudo and Youji Miyamoto
- Journal Title
  
  In Vitro Cellular & Developmental Biology. Animal
  
  Volume: 58 Issue: 8 Pages: 693-701
- DOI
  10.1007/s11626-022-00718-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K10121
[Journal Article] Gene signature of human oral mucosa fibroblasts: comparison with dermal fibroblasts and induced pluripotent stem cells.2015
- Author(s)
  Miyoshi K, Horiguchi T, Tanimura A, Hagita H, Noma T.
- Journal Title
  
  BioMed Res Int.
  
  Volume: 印刷中
- NAID
  120006783219
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24592801
[Journal Article] Gene signature of human oral mucosa fibroblasts: comparison with dermal fibroblasts and induced pluripotent stem cells.2015
- Author(s)
  Miyoshi K, Horiguchi T, Tanimura A, Hagita H, Noma T.
- Journal Title
  
  Biomed Res Int.
  
  Volume: 2015 Pages: 1-19
- DOI
  10.1155/2015/121575
- NAID
  120006783219
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K11041
[Journal Article] Dissection of morphological and metabolic differentiation of ameloblasts via ectopic SP6 expression2012
- Author(s)
  Muto T, Miyoshi K, Horiguchi T, Noma T
- Journal Title
  
  J Med Invest
  
  Volume: 59 Pages: 59-68
- NAID
  130004465272
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21791805
[Journal Article] Possible linkage of SP6 transcriptional activity with amelogenesis by protein stabilization2011
- Author(s)
  Utami TW, Miyoshi K, Hagita H, Yanuaryska RD, Horiguchi T, Noma T
- Journal Title
  
  J Biomed Biotech
  
  Volume: ID320987 Issue: 1 Pages: 1-10
- DOI
  10.1155/2011/320987
- NAID
  120006783225
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21791805, KAKENHI-PROJECT-23592735
[Journal Article] Isolation and characterization of mouse Specificity Protein 6 promoter2010
- Author(s)
  Wahyudi IA, Horiguchi T, Miyoshi K, Muto T, Utami TW, Hagita H, Noma T
- Journal Title
  
  Indones J Dent Res
  
  Volume: 1(1) Pages: 21-34
- NAID
  120006783224
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21791805
[Journal Article] Dynamic Changes of Sp6 Transgene Expression in Dental Epithelial Cells during Long-term Culture
- Author(s)
  Utami TW, Miyoshi K, Hagita H, Yanuaryska RD, Horiguchi T, Noma T
- Journal Title
  
  Indones J Dent Res
  
  Volume: (in press)
- NAID
  120006783223
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21791805
[Journal Article] Novel genetic linkage of rat Sp6 mutation to amelogenesis imperfecta
- Author(s)
  Muto T*, Miyoshi K*, Hagita H, Horiguchi T, Noma T
- Journal Title
  
  Orphanet J Rare Dis
  
  Volume: (in press)
- NAID
  120006783222
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21791805
[Presentation] 口腔粘膜線維芽細胞の代謝と細胞の特性　～トランスクリプトーム解析からのアプローチ～2017
- Author(s)
  三好圭子
- Organizer
  第１２２回　日本解剖学会総会・全国学術集会
- Place of Presentation
  長崎大学坂本キャンパス（長崎県・長崎市）
- Year and Date
  2017-03-30
- Invited
- Data Source
  KAKENHI-PROJECT-15K11041
[Presentation] GBA 遺伝子5´側バリアントの発現パターン解析2017
- Author(s)
  三好圭子, 萩田浩子, 谷村綾子, 堀口大吾, 野間隆文
- Organizer
  2017 年度生命科学系学会合同年次大会ConBio 2017 （神戸、兵庫）
- Data Source
  KAKENHI-PROJECT-15K11041
[Presentation] 新規異型ゴーシェ病メカニズムの探索2016
- Author(s)
  三好圭子
- Organizer
  平成27年度革新的特色研究シンポジウム「再生医学研究プラットフォームの構築と臨床応用への展開」
- Place of Presentation
  徳島大学（徳島県徳島市）
- Year and Date
  2016-01-27
- Data Source
  KAKENHI-PROJECT-15K11041
[Presentation] 新規異型ゴーシェ病疾患メカニズム解明の試み2015
- Author(s)
  三好圭子
- Organizer
  平成26年度革新的特色研究シンポジウム「再生医学研究プラットフォームの構築と臨床応用への展開」
- Place of Presentation
  徳島大学（徳島県徳島市）
- Year and Date
  2015-03-04
- Data Source
  KAKENHI-PROJECT-24592801
[Presentation] 口腔粘膜線維芽細胞の有用性とiPS 細胞を用いた再生歯科学へのアプローチ2014
- Author(s)
  三好圭子
- Organizer
  第 12 回日本再生歯科医学会学術大会・総会
- Place of Presentation
  徳島大学（徳島県徳島市）
- Year and Date
  2014-08-26
- Data Source
  KAKENHI-PROJECT-24592801
[Presentation] Gaucher disease caused by possible atypical mechanism.
- Author(s)
  Miyoshi K, Horiguchi T, Tanimura A, Hagita H, Toda Y, Kagami S, Mori K, Tsuji D, Itoh K, and Noma T.
- Organizer
  Gordon Research Conference, Lysosomal Diseases
- Place of Presentation
  Galveston, TX, USA
- Year and Date
  2015-03-15 – 2015-03-20
- Data Source
  KAKENHI-PROJECT-24592801
[Presentation] 疾患iPS細胞の樹立と遺伝子変異の同定
- Author(s)
  三好圭子
- Organizer
  平成２５年度革新的特色研究シンポジウム「再生医学研究プラットフォームの構築と臨床応用への展開及び産官学連携推進報告会」
- Place of Presentation
  徳島大学　藤井節郎記念ホール（徳島県）
- Data Source
  KAKENHI-PROJECT-24592801
[Presentation] 皮膚線維芽細胞, iPS細胞との網羅的遺伝子発現の比較解析.
- Author(s)
  三好圭子, 堀口大吾, 谷村綾子，萩田浩子, 野間隆文.
- Organizer
  第14回日本再生医療学会総会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2015-03-19 – 2015-03-21
- Data Source
  KAKENHI-PROJECT-24592801
[Presentation] 口腔粘膜線維芽細胞を用いた疾患iPS細胞の樹立と今後の展望 -口腔から再生医学・再生医療をめざして-
- Author(s)
  三好圭子
- Organizer
  第10回HBS公開シンポジウム「再生医学研究の現状と臨床応用への課題」
- Place of Presentation
  徳島大学　長井記念ホール（徳島県）
- Invited
- Data Source
  KAKENHI-PROJECT-24592801

1. NOMA Takafumi (40189428)

# of Collaborated Projects: 4 results

# of Collaborated Products: 5 results
2. HOSOKI Maki (10228421)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. 堀口大吾 (70304532)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
4. 井上美穂 (20271059)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. 松香芳三 (90243477)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. 萩田浩子 (30512123)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. 毛利安宏 (80464353)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
8. 松尾敬志 (30173800)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 西川啓介 (10202235)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 宮城麻友 (20625719)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 田島登誉子 (80335801)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 大島正充 (00548307)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 山村佳子 (00581406)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
14. 宮本洋二 (20200214)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
15. 工藤保誠 (50314753)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results

Miyoshi Keiko 三好 圭子

MIYOSHI Keiko 三好 圭子

三好 圭子 ミヨシ ケイコ

Research Projects

Research Products

Co-Researchers

RNA修飾解析により紐解くゴーシェ病の新規修飾因子の特定Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

RNA修飾による糖脂質分解酵素活性制御機構の解明とゴーシェ病克服への挑戦Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The identification of genes involved in the maintenance and regeneration of salivary gland stem / progenitor cells and application to new xerostomia treatment

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Establishment of the new diagnosis biomarkers for metal allergy by analyzing peripheral blood miRNA expression

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Explore of the GBA translation regulatory mechanism by RNA epigenetics: To find the therapeutic targets for Gaucher diseasePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Metal allergy; What is the difference between sensitization and onset? -Identification of specific genes-

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Characterization of Gaucher disease by new gene mutation using patient-derived oral mucosa fibroblastsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Establishment of disease model system using patient-derived oral mucosa fibroblast-iPSCs and development of new therapyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Relationship between transcriptional activity and structure of tooth specific transcription factor Sp6 and identification of its interaction moleculesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

歯原性上皮細胞および歯髄細胞を用いた歯質再建のための細胞療法の開発

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

エナメル芽細胞の分化、成熟、維持機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

口腔乾燥症の治療に向けた唾液腺腺房細胞の分化メカニズムの解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] miR 155 5p can be involved in acquisition of osseointegration on titanium surface2022

Author(s)

Miyoshi Keiko 三好圭子

MIYOSHI Keiko 三好圭子

三好圭子ミヨシケイコ

[Presentation] 口腔粘膜線維芽細胞の代謝と細胞の特性　～トランスクリプトーム解析からのアプローチ～2017