uto yoshihiro 宇都義浩

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UTO Yoshihiro 宇都義浩

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Researcher Number	20304553
Other IDs
External Links
Affiliation (Current)	2025: 徳島大学, 大学院社会産業理工学研究部(生物資源産業学域), 教授
Affiliation (based on the past Project Information) *help	2017 – 2024: 徳島大学, 大学院社会産業理工学研究部(生物資源産業学域), 教授 2016: 徳島大学, 大学院生物資源産業学研究部, 教授 2016: 徳島大学, 工学部, 准教授 2015 – 2016: 徳島大学, 大学院ソシオテクノサイエンス研究部, 教授 2014 – 2016: 徳島大学, ソシオテクノサイエンス研究部, 教授 … More 2013: 徳島大学, 大学院ソシオテクノサイエンス研究部, 准教授 2013: 徳島大学, 工学部, 准教授 2011 – 2013: 徳島大学, ソシオテクノサイエンス研究部, 准教授 2007 – 2010: The University of Tokushima, Institute of Technolog and science, Guraduate School, Associate Professor 2008: The University of Tokushima, 大学院・ンシオテクノサイエンス研究部, 准教授 2007: 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 准教授 2006: 徳島大学, 大学院ソシオテクノサイエンス研究部, 助教授 2006: 徳島大学, 大学院・ソシオテクノサイエンス研究部, 助教授 2001 – 2005: 徳島大学, 工学部, 助手 Less
Review Section/Research Field	Principal Investigator Radiation science / Basic Section 52040:Radiological sciences-related / Radiation science Except Principal Investigator Digestive surgery / Radiation science / Basic Section 56030:Urology-related / Basic Section 21010:Power engineering-related / Basic Section 50020:Tumor diagnostics and therapeutics-related / Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields / Basic Section 55020:Digestive surgery-related … More / Bio-related chemistry / Tumor therapeutics / Neurosurgery / 医薬分子機能学 / Power engineering/Power conversion/Electric machinery / Environmental conscious materials and recycle / Clinical oncology / Drug development chemistry Less
Keywords	Principal Investigator 放射線増感剤 / 腫瘍移植鶏卵 / 低酸素細胞放射線増感剤 / グルコース / ダサチニブ / アセチルグルコース / 発育鶏卵 / 薬物動態 / 2-ニトロイミダゾール / pifithrin-α … More / 癌 / EGFR自己リン酸化阻害剤 / エルロチニブ / ゲフィチニブ / アセチルグルコース修飾放射線増感剤 / アセチル化グルコース / EGFR / 分子標的薬剤 / アセチルグルコース修飾ゲフィチニブ / 低酸素腫瘍 / 解糖系阻害 / 解糖系酵素 / 放射線腫瘍学 / 固形腫瘍 / 疎水性 / 分子軌道 / マクロファージ活性化 / 糖ハイブリッド / 低酸素腫瘍細胞 / マクロファージ / p53阻害剤 / アポトーシス / 温熱 / ニトロイミダゾール / 放射線防護剤 / p53阻害財 / ナフタレンジイミド / p53タンパク / DNA結合分子 / スレーディングインターカレータ … More Except Principal Investigator 5-アミノレブリン酸 / 個別化医療 / 鶏卵 / PDX / 尿路上皮癌 / 光線力学的治療 / TX-1877 / TX-2068 / パルス電界 / がん / バイオエレクトリクス / ナノ秒パルス電界 / アポトーシス / 光線力学療法 / 効果増強剤 / トランスポーター / 光線力学的療法 / 低酸素 / 放射線 / 外科 / 癌 / Na+/H+交換輸送体5 / 大腸癌 / 腎癌 / 免疫チェックポイント阻害薬 / 癌細胞 / 生体作用 / 小胞体ストレス応答 / 電気生体作用 / がんの診断と治療 / チロシンキナーゼ阻害剤 / チロシンキナーゼ阻害薬 / 薬剤スクリーニング / 薬剤耐性 / 泌尿器癌 / CAM / 腎細胞癌 / 遊走抑制効果 / 浸潤抑制効果 / 殺細胞活性 / UTX-143 / アミロライド / 抗がん剤 / ナフタレンジイミド / c-myc / c-kit / ヒトテロメアDNA / 4本鎖DNAをターゲットとした抗がん剤 / テロメアDNA / 抗癌剤 / 環状ナフタレンジイミド / 4本鎖DNA / ５-アミノレブリン酸 / 効果増強 / 炎症性ｻｲﾄｶｲﾝ / Ｍ１/Ｍ２マクロファージ / 神経再生 / phagocytosis / 炎症性サイトカイン / Ｍ１/Ｍ２様マクロファージ / 脳梗塞 / 脳・神経 / 生物物理理学計算モデル / 最適化 / 放射線感受性 / 生物物理学的計算モデル / 免疫放射線療法 / 時間放射線生物学 / Surgery / Metastasis / Anviogenesis / Sensitizer / Sensitivity / Hypoxia / Radiation / Colorectal cancer / 転移 / 血管新生 / 増感剤 / 感受性 / N-Acetylgalactosamine / Hypoxia Orientation / Macrophage / Hypoxic Cell Radiosensitizer / TX-2073 / GcMAF / 貪食活性 / N-アセチルガラクトサミン / 低酸素指向性 / マクロファージ / 低酸素細胞放射線増感剤 / in vivo / フローサイトメトリー / 発育鶏卵法 / パルス高電界 / がん治療 / パルスパワー / バイオマス / リグノセルロース / リグノセルロース系バイオマス / クルクミン / 中性子 / ボロントレースドラッグ / インターベンショナルラジオロジー（ＩＶＲ） / 耐性細胞 / 増強剤 / ABCG2 / PEPT1 / ALA / 5-ALA / PDT / 膵臓癌 / 有機化学 / Na+/H+交換輸送体 / 鶏胚漿尿膜 / FTY720 / ポリイン / キラリティー / スワインソニン / ブレフェルジン / ナノアセンブリー Less

アセチルグルコース修飾スルファサラジンの分子設計・合成と放射線増感作用の評価Principal Investigator
- Principal Investigator
  
  宇都義浩
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  The University of Tokushima
RCC Precision Medicine Project using PDX models
- Principal Investigator
  
  高橋正幸
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  The University of Tokushima
Development of a novel TKI derivative for enhancing the anticancer potential of 5-aminolevulinic acid-based photodynamic therapy
- Principal Investigator
  
  Endo Yoshio
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Kanazawa University
Design and synthesis of acetylglucose-modified dasatinib and evaluation of radiosensitizing effectPrincipal Investigator
- Principal Investigator
  
  UTO Yoshihiro
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  The University of Tokushima
Experimental research on the biological action of nanosecond pulsed electric fields and its evolving to medical technology
- Principal Investigator
  
  下村直行
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 21010:Power engineering-related
- Research Institution
  The University of Tokushima
Development of a selective inhibitor against Na+/H+ exchange transporter 5 (NHE5), which is a target candidate molecule for gastrointestinal cancer.
- Principal Investigator
  
  Ninomiya Itasu
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Kanazawa University
Development of a next-generation patient-derived cancer model using chicken eggs and establishment of a drug screening method
- Principal Investigator
  
  KANAYAMA Hiroomi
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
- Research Institution
  The University of Tokushima
Elucidation of radiosensitization mechanism of acetylglucose-modified gefitinib and development of novel radiosensitizerPrincipal Investigator
- Principal Investigator
  
  UTO Yoshihiro
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Radiation science
- Research Institution
  The University of Tokushima
Development of novel colon cancer treatment by Na+/H+ exchanger inhibitor
- Principal Investigator
  
  Ninomiya Itasu
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Kanazawa University
Development of chronoradiobiology model in combination of immune cells and radiosensitizer
- Principal Investigator
  
  Oita Masataka
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Radiation science
- Research Institution
  Okayama University
Activation of M2-type macrophages in the late phase of cerebral ischemia promotes neurogenesis with cleaning of the infarct area.
- Principal Investigator
  
  Yagi Kenji
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurosurgery
- Research Institution
  Fukuoka University
  The University of Tokushima
Creation and evaluation of tetraplex DNA specific molecules aiming at anti-cancer drug with low side effect
- Principal Investigator
  
  Takenaka Shigeori
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Bio-related chemistry
- Research Institution
  Kyushu Institute of Technology
Development of radiosensitizers based on antitumor/molecular targeted drugs modified by acetylglucosePrincipal Investigator
- Principal Investigator
  
  Uto Yoshihiro
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Radiation science
- Research Institution
  The University of Tokushima
Development of novel Schiff base derivative for enhancing the anticancer potential of 5-aminolevulinic acid-based photodynamic therapy
- Principal Investigator
  
  Endo Yoshio
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor therapeutics
- Research Institution
  Kanazawa University
Development of production process of high value-added and environmentally friendly products from lignocellulosic biomass
- Principal Investigator
  
  Nakamura Yoshitoshi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Environmental conscious materials and recycle
- Research Institution
  The University of Tokushima
Establishment of Cancer Therapy Using Pulsed High Electric Fields and the Development Based on Acceleration of In Vivo Experiments
- Principal Investigator
  
  Shimomura Naoyuki
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Power engineering/Power conversion/Electric machinery
- Research Institution
  The University of Tokushima
Development of boron trace drug with broad molecule pursuit and destructive power by neutron irradiation
- Principal Investigator
  
  HORI Hitoshi
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Radiation science
- Research Institution
  The University of Tokushima
Development of novel lead compounds with enhancing effect on ALA-based photodynamic therapy
- Principal Investigator
  
  ENDO YOSHIO
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Clinical oncology
- Research Institution
  Kanazawa University
Design of radiosensitizers targeting for glycolysis of hypoxic tumor based on tumor implanted chick embryoPrincipal Investigator
- Principal Investigator
  
  UTO Yoshihiro
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Radiation science
- Research Institution
  The University of Tokushima
Development of multi-functional radiosensitizer based on in vivo radiosensitizing activity using tumor-implant chick embryoPrincipal Investigator
- Principal Investigator
  
  UTO Yoshihiro
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Radiation science
- Research Institution
  The University of Tokushima
低酸素環境を標的とした膵臓癌に対する新たな治療法の開発
- Principal Investigator
  
  MIYAKE Kentaro
- Project Period (FY)
  2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  The University of Tokushima
Design of radiosensitizer and p53-reactivator using hypoxic tumor associated macrophagePrincipal Investigator
- Principal Investigator
  
  UTO Yoshihiro
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Radiation science
- Research Institution
  The University of Tokushima
Development of new chemoradiosensitizing method for colorectal cancer
- Principal Investigator
  
  NISHIOKA Masanori
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  The University of Tokushima
標的分子との空間的相互作用のコントロールを指向したナノアセンブリー薬剤の分子設計
- Principal Investigator
  
  HORI Hitoshi
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Drug development chemistry
- Research Institution
  The University of Tokushima
p53の阻害を介して正常細胞へのダメージを軽減する低酸素細胞放射線増感剤の開発Principal Investigator
- Principal Investigator
  
  宇都義浩
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Radiation science
- Research Institution
  The University of Tokushima
Design of hypoxic cell radiosensitizer utilized for hypoxia orientation of macrophage
- Principal Investigator
  
  HORI Hitoshi
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  医薬分子機能学
- Research Institution
  The University of Tokushima
DNAに作用するスレーディングインターカレータ型低酸素細胞放射線増感剤の開発Principal Investigator
- Principal Investigator
  
  宇都義浩
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Radiation science
- Research Institution
  The University of Tokushima

[Book] 実験医学「癌と微小環境」(第4章2. ハイポキシアを標的とした抗癌剤)2009
- Author(s)
  宇都義浩
- Publisher
  株式会社羊土社
- Data Source
  KAKENHI-PROJECT-18790892
[Book] 酸素をターゲットとしたがんの治療東京2009
- Author(s)
  堀均, 宇都義浩, 永澤秀子, 中田栄司
- Total Pages
  596
- Publisher
  朝倉書店
- Data Source
  KAKENHI-PROJECT-21791198
[Journal Article] 当院における患者由来PDXモデルを用いた取り組み-個別化医療を目指して-2023
- Author(s)
  大豆本圭、高橋正幸、宇都義浩、上原久典
- Journal Title
  
  泌尿器科外科
  
  Volume: 36 Pages: 906-908
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K08736
[Journal Article] Effects of nanosecond pulsed electric fields application on cancer cell and combination of anticancer drug2022
- Author(s)
  Enomoto Soichiro、Konishi Daisuke、Uto Yoshihiro、Shimomura Naoyuki
- Journal Title
  
  Electrical Engineering in Japan
  
  Volume: - Issue: 2
- DOI
  10.1002/eej.23376
- NAID
  130008123469
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K20929
[Journal Article] Effects of Nanosecond Pulsed Electric Fields Application on Cancer Cell and Combination of Anticancer Drug2021
- Author(s)
  榎本壮一郎, 小西大輔, 宇都義浩, 下村直行
- Journal Title
  
  IEEJ Transactions on Fundamentals and Materials
  
  Volume: 141 Issue: 12 Pages: 657-664
- DOI
  10.1541/ieejfms.141.657
- NAID
  130008123469
- ISSN
  0385-4205, 1347-5533
- Year and Date
  2021-12-01
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K20929
[Journal Article] 鶏卵を用いた次世代患者由来がんモデルの開発2020
- Author(s)
  大豆本圭、金山博臣、上原久典、宇都義浩
- Journal Title
  
  Medical　Science Digest
  
  Volume: 46 Pages: 59-61
- Data Source
  KAKENHI-PROJECT-19K22689
[Journal Article] In vivo drug screening method of radiosensitizers using tumor-bearing chick embryo2019
- Author(s)
  Uto Y, Abe C, Futawaka M, Yamada H, Tominaga M, Endo Y
- Journal Title
  
  Enzymes
  
  Volume: 46 Pages: 113-127
- DOI
  10.1016/bs.enz.2019.08.008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K10480
[Journal Article] Correlation Between Radiosensitizing Activity and the Stereo-structure of the TX-2036 Series of Molecules.2019
- Author(s)
  Ohkura K, Tabata A, Uto Y, Hori H.
- Journal Title
  
  Anticancer Res.
  
  Volume: 39 Issue: 8 Pages: 4479-4483
- DOI
  10.21873/anticanres.13622
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06764, KAKENHI-PROJECT-17K10480
[Journal Article] Immunologicalaspects of Improved Tumor and Normal Tissue Responses Using Biophysical modelling2018
- Author(s)
  Oita M, Udaka M, Aoyama H, Sasaki M, Tominaga M, Uto Y
- Journal Title
  
  Medical Physics
  
  Volume: 6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09998
[Journal Article] Effect of dose rate on antitumor activity in hypoxic cells by using flattening filter free beams2018
- Author(s)
  Hara T, Tominaga M, Yajyu K, Kouzaki R, Yamada H, Sasaki M, Azane S, Uto Y
- Journal Title
  
  International Journal of Radiation Research
  
  Volume: 掲載予定
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09998
[Journal Article] Photodynamic Therapy Mediated by a Novel Chlorin Derivative, TONS 501-Na, in EMT6 cells.2017
- Author(s)
  Osaki T, Sakata I, Uto Y, Azuma K, Murahata Y, Tsuka T, Itoh N, Imagawa T, Okamoto Y.
- Journal Title
  
  Anticancer Res
  
  Volume: 37 Pages: 1723-1728
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09998
[Journal Article] Development of a novel Schiff base derivative for enhancing the anticancer potential of 5-aminolevulinic acid-based photodynamic therapy.2017
- Author(s)
  Shinohara Y, Endo Y, Abe C, Shiba I, Ishizuka M, Tanaka T, Yonemura Y, Ogura SI, Tominaga M, Yamada H, Uto Y.
- Journal Title
  
  Photodiagnosis Photodyn Ther
  
  Volume: 20 Pages: 182-188
- DOI
  10.1016/j.pdpdt.2017.10.014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09998, KAKENHI-PROJECT-16K01935
[Journal Article] Design and Synthesis of Novel Anti-metastatic Hypoxic Cytotoxin TX-2137 Targeting AKT Kinase.2017
- Author(s)
  Shiba I, Kouzaki R, Yamada H, Endo Y, Takino T, Sato H, Kitazato K, Kageji T, Nagahiro S, Uto Y.
- Journal Title
  
  Anticancer Res
  
  Volume: 37 Pages: 3877-3883
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09998
[Journal Article] 1,2,3-Triazolyl esterization of PAK1-blocking propolis ingredients, artepillin C (ARC) and caffeic acid (CA), for boosting their anti-cancer/anti-PAK1 activities along with cell-permeability.2017
- Author(s)
  Takahashi H, Nguyen BCQ, Uto Y, Shahinozzaman M, Tawata S, Maruta H.
- Journal Title
  
  Drug Discov Ther
  
  Volume: 11 Pages: 104-109
- NAID
  130007040206
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09998
[Journal Article] Both triazolyl ester of ketorolac (15K) and YM155 inhibit the embryonic angiogenesis <i>in ovo</i> (fertilized eggs) <i>via</i> their common PAK1-survivin/VEGF signaling pathway2017
- Author(s)
  Ahn MR, Bae JY, Jeong DH, Takahashi H, Uto Y, Maruta H.
- Journal Title
  
  Drug Discoveries & Therapeutics
  
  Volume: 11 Issue: 6 Pages: 300-306
- DOI
  10.5582/ddt.2017.01058
- NAID
  130006308126
- ISSN
  1881-7831, 1881-784X
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09998
[Journal Article] Interactive Analysis of TX-1123 with Cyclo-oxygenase: Design of COX2 Selective TX Analogs.2017
- Author(s)
  Ohkura K, Tatematsu Y, Kawaguchi Y, Uto Y, Hori H.
- Journal Title
  
  Anticancer Res
  
  Volume: 37 Pages: 3849-3854
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09998
[Journal Article] Case Report: A Non-small Cell Lung Cancer Patient Treated with GcMAF, Sonodynamic Therapy and Tumor Treating Fields.2016
- Author(s)
  Inui T, Amitani H, Kubo K, Kuchiike D, Uto Y, Nishikata T, Mette M
- Journal Title
  
  Anticancer Research
  
  Volume: 36 Pages: 3767-70
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09998
[Journal Article] Case Report: GcMAF Treatment in a Patient with Multiple Sclerosis2016
- Author(s)
  Inui T, Katsuura G, Kubo K, Kuchiike D, Chenery L, Uto Y, Nishikata T, Mette M
- Journal Title
  
  Anticancer Research
  
  Volume: 36 Pages: 3771-74
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09998
[Journal Article] Does the biophysical modelling for immunological aspects in radiotherapy precisely predict tumor and normal tissue responses?2016
- Author(s)
  M.Oita, K.Nakata, H.Aoyama, M.Sasaki, M.Tominaga, H.Hoda, Y.Uto
- Journal Title
  
  Medical Physics
  
  Volume: 43 Issue: 6Part24 Pages: 3621-3621
- DOI
  10.1118/1.4956867
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09998
[Journal Article] Macrophages Exhibit a Large Repertoire of Activation States via Multiple Mechanisms of Macrophage-activating Factors.2016
- Author(s)
  Sumiya YU, Inoue T, Ishikawa M, Inui T, Kuchiike D, Kubo K, Uto Y, Nishikata T
- Journal Title
  
  Anticancer Research
  
  Volume: 36 Pages: 3619-23
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09998
[Journal Article] Application of biophysical modelling for normal tissue response with immunological aspects in radiotherapy2016
- Author(s)
  M.Oita, H.Aoyama, M.Sasaki, M.Tominaga, H.Hoda, Y.Uto
- Journal Title
  
  Radiotherapy & Oncology
  
  Volume: 118 Pages: S79-S80
- DOI
  10.1016/s0167-8140(16)30162-1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09998
[Journal Article] Macrophage Activation Mechanisms in Human Monocytic Cell Line-derived Macrophages.2015
- Author(s)
  Yu Sumiya, Mami Ishikawa, Takahiro Inoue, Toshio Inui, Daisuke Kuchiike, Kentaro Kubo, Yoshihiro Uto and Takahito Nishikata
- Journal Title
  
  Anticancer Research
  
  Volume: 35 Pages: 4447-4451
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09998
[Journal Article] Degalactosylated/Desialylated Bovine Colostrum Induces Macrophage Phagocytic Activity Independently of Inflammatory Cytokine Production.2015
- Author(s)
  Yoshihiro Uto, Tomohito Kawai, Toshihide Sasaki, Ken Hamada, Hisatsugu Yamada, Daisuke Kuchiike, Kentaro Kubo, Toshio Inui, Martin Mette, Ken Tokunaga, Akio Hayakawa, Akiteru Go and Tomohiro Oosaki
- Journal Title
  
  Anticancer Research
  
  Volume: 35 Pages: 4487-4492
- Data Source
  KAKENHI-PROJECT-15K09998
[Journal Article] Investigation of Effect of Applied Nanosecond Pulsed Electric Fields on Tumor2015
- Author(s)
  Shuzo Matsubara, Akito Nakagawa, Shota Kuniyasu, Kenji Teranishi, Yoshihiro Uto, and Naoyuki Shimomura
- Journal Title
  
  Proceedings of 2015 IEEE Pulsed Power Conference
  
  Volume: 1 Pages: 374-378
- DOI
  10.1109/ppc.2015.7296945
- Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25289075
[Journal Article] Radiosensitivity uncertainty evaluation for the in vitro biophysical modeling of EMT6 cells.2014
- Author(s)
  Oita M, Uto Y, Tominaga M, Sasaki M, Hara Y, Kishi T, Hori H.
- Journal Title
  
  Anticancer Research
  
  Volume: 34 Pages: 4621-4626
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26461891
[Journal Article] Evaluation of the in vivo antioxidative activity of redox nanoparticles by using a developing chicken egg as an alternative animal model2014
- Author(s)
  Abe C, Uto Y, Kawasaki A, Noguchi C, Tanaka R, Yoshitomi T, Nagasaki Y, Endo Y, Hori H
- Journal Title
  
  J Control Release
  
  Volume: 182 Pages: 67-72
- DOI
  10.1016/j.jconrel.2014.03.015
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591842
[Journal Article] In Vivo Experimental Study of Nanosecond Pulsed Electric Field Effects on Solid Tumors2013
- Author(s)
  Masataka Nagahama, Naoyuki Shimomura, Akito Nakagawa, Kenji Teranishi, Yoshihiro Uto and Hitoshi Hori
- Journal Title
  
  IEEE Transactions on Dielectrics and Electrical Insulation
  
  Volume: 20 Issue: 4 Pages: 1266-1272
- DOI
  10.1109/tdei.2013.6571443
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25289075
[Journal Article] Boron tracedrug design for neutron dynamic therapeutics for LDL2013
- Author(s)
  Hori H, Nazumi Y, Uto Y
- Journal Title
  
  Adv Exp Med Biol
  
  Volume: 789 Pages: 385-9
- DOI
  10.1007/978-1-4614-7411-1_51
- ISBN
  9781461472568, 9781461474111
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659566
[Journal Article] Boron tracedrugs challenge for neutron dynamic therapy2012
- Author(s)
  Hori H, Uto Y, Nakata E
- Journal Title
  
  Anticancer Res
  
  Volume: 32 Pages: 2235-9
- Data Source
  KAKENHI-PROJECT-24659566
[Journal Article] Boron tracedrug : design, synthesis, and pharmacological activity of phenolic BODIPY-containing antioxidants as traceable next-generation drug model2012
- Author(s)
  Nakata E, Koizumi M, Yamashita Y, Uto Y, Hori H
- Journal Title
  
  Adv Exp Med Biol
  
  Volume: 737 Pages: 301-6
- DOI
  10.1007/978-1-4614-1566-4_44
- ISBN
  9781461415657, 9781461415664
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659566
[Journal Article] The novel hypoxic cytotoxin, TX-2098 has antitumor effect in pancreatic cancer ; possible mechanism through inhibiting VEGF and hypoxia inducible factor-1α targeted gene expression2012
- Author(s)
  Kotaro Miyake
- Journal Title
  
  Exp.Cell.Res.
  
  Volume: 24(In press) Issue: 13 Pages: 1554-1563
- DOI
  10.1016/j.yexcr.2012.03.013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390033, KAKENHI-PROJECT-23591842, KAKENHI-PROJECT-24390029
[Journal Article] Synthesis and photophysical properties of new SNARF derivatives as dual emission pH sensors2011
- Author(s)
  Nakata E, Nazumi Y, Yukimachi Y, Uto Y, Maezawa H, Hashimoto T, Okamoto Y, Hori H
- Journal Title
  
  Bioorg Med Chem Lett 21
  
  Pages: 1663-1666
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21791198
[Journal Article] Evaluation of the In vivo Radiosensitizing Activity of Etanidazole Using Tumor-bearing Chick Embryo.2011
- Author(s)
  Abe C, Uto Y, et al.
- Journal Title
  
  Journal of Radiation Research
  
  Volume: 52 Pages: 208-214
- NAID
  10027956760
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21791198
[Journal Article] 発育鶏卵を利用した創薬研究と将来展望2011
- Author(s)
  安部千秋,宇都義浩,遠藤良夫,堀均
- Journal Title
  
  放射線生物研究
  
  Volume: 46 Pages: 221-233
- Data Source
  KAKENHI-PROJECT-23591842
[Journal Article] Evaluation of the in vivo radiosensitizing activity of etanidazole using tumor-bearing chick embryo2011
- Author(s)
  Abe C, Uto Y, Nakae T, Shinmoto Y, Sano K, Nakata H, Teraoka M, Endo Y, Maezawa H, Masunaga S, Nakata E, Hori H.
- Journal Title
  
  Journal of Radiation Research
  
  Volume: 52 Pages: 208-214
- NAID
  10027956760
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591842
[Journal Article] Evaluation of the In vivo Radiosensitizing Activity of Etanidazole Using Tumor-bearing Chick Embryo2011
- Author(s)
  Abe C, Uto Y, Nakae T, Shinmoto Y, Sano K, Nakata H, Teraoka M, Endo Y, Maezawa H, Masunaga S, Nakata E, Hori H
- Journal Title
  
  J Radiat Res
  
  Volume: 52 Pages: 208-14
- NAID
  10027956760
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591842
[Journal Article] Evaluation of the In vivo Radiosensitizing Activity of Etanidazole Using Tumor-bearing Chick Embryo2011
- Author(s)
  Abe C, Uto Y, Nakae T, Shinmoto Y, Sano K, Nakata H, Teraoka M, Endo Y, Maezawa H, Masunaga S, Nakata E, Hori H
- Journal Title
  
  J Radiat Res 52
  
  Pages: 208-214
- NAID
  10027956760
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21791198
[Journal Article] Design of novel hypoxia-targeting IDO hybrid inhibitors conjugated with an unsubstituted L-TRP as an IDO affinity moiety2010
- Author(s)
  Nakashima H, Ikkyu K, Nakashima K, Sano K, Uto Y, Nakata E, Nagasawa H, Sugimoto H, Shiro Y, Nakagawa Y, Hori H
- Journal Title
  
  Adv Exp Med Biol 662
  
  Pages: 415-421
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21791198
[Journal Article] A newly designed cell-permeable SNARF derivative as an effective intracellular pH indicator2010
- Author(s)
  Nakata E, Yukimachi Y, Nazumi Y, Uto Y, Maezawa H, Hashimoto T, Okamoto Y, Hori H
- Journal Title
  
  Chem Commun (Camb) 46
  
  Pages: 3526-3528
- NAID
  110008621031
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21791198
[Journal Article] Medicinal electronomics bricolage design of hypoxia-targeting antineoplastic drugs and invention of boron tracedrugs as innovative future-architectural drugs2010
- Author(s)
  Hori H, Uto Y, Nakata E
- Journal Title
  
  Anticancer Res 30
  
  Pages: 3233-3242
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21791198
[Journal Article] Medicinal electronomics bricolage design of hypoxia-targeting antineoplastic drugs and invention of boron tracedrugs as innovative future-architectural drugs.2010
- Author(s)
  Hori H, Uto Y, et al.
- Journal Title
  
  Anticancer Research
  
  Volume: 30 Pages: 3233-3242
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21791198
[Journal Article] Vitamin D Binding Protein-Macrophage Activating Factor Inhibits HCC in SCID Mice2010
- Author(s)
  Nonaka K, Onizuka S, Ishibashi H, Uto Y, Hori H, Nakayama T, Matsuura N, Kanematsu T, Fujioka H
- Journal Title
  
  J Surg Res in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21791198
[Journal Article] 次世代動物実験系としての腫瘍移植鶏卵の構築と放射線照射による腫瘍成長阻害活性2009
- Author(s)
  安部千秋, 宇都義浩, 遠藤良夫, 新元優也, 中島宏一郎, 佐野圭一郎, 佐々木有紀, 皆巳和賢, 前澤博, 増永慎一郎, 中田栄司, 堀均
- Journal Title
  
  放射線生物研究 44
  
  Pages: 233-241
- Data Source
  KAKENHI-PROJECT-21791198
[Journal Article] Correlation between antiangiogenic activity and antioxidant activity of various components from propolis2009
- Author(s)
  Ahn MR, Kunimasa K, Kumazawa S, Nakayama T, Kaji K, Uto Y, Hori H, Nagasawa H, Ohta T
- Journal Title
  
  Mol Nutr Food Res 53
  
  Pages: 643-651
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21791198
[Journal Article] ハイポキシアを標的とした抗癌剤2009
- Author(s)
  宇都義浩, 中田栄司,永澤秀子, 堀均
- Journal Title
  
  実験医学(増刊) 27巻
  
  Pages: 177-183
- Data Source
  KAKENHI-PROJECT-18790892
[Journal Article] Design of a bioreductively-activated fluorescent pH probe for tumor hypoxia imaging2009
- Author(s)
  Nakata E, Yukimachi Y, Kariyazono H, Im S, Abe C, Uto Y, Maezawa H, Hashimoto T, Okamoto Y, Hori H
- Journal Title
  
  Bioorg Med Chem 17
  
  Pages: 6952-6958
- NAID
  110007594198
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21791198
[Journal Article] A chemical biosynthesis design for an antiatherosclerosis drug by acyclic tocopherol intermediate analogue based on "isoprenomics"2009
- Author(s)
  Yoshihiro Uto
- Journal Title
  
  Advances in experimental medicine and biology 645
  
  Pages: 109-114
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21791198
[Journal Article] A chemical biosynthesis design for an antiatherosclerosis drug by acyclic tocopherol intermediate analogue based on "isoprenomics"2009
- Author(s)
  Uto Y, Koyama D, Otsuki M, Otomo N, Shirai T, Abe C, Nakata E, Nagasawa H, Hori H
- Journal Title
  
  Adv Exp Med Biol 645
  
  Pages: 109-114
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21791198
[Journal Article] Downregulation of matrix metalloprotease-9 and urokinase plasminogen activator by TX-1877 results in decreased tumor growth and metastasis on xenograft model of rectal cancer2009
- Author(s)
  Miyake K, Shimada M, Nishioka M, Sugimoto K, Batmunkh E, Uto Y, Nagasawa H, Hori H,
- Journal Title
  
  Cancer Chemotherapy Pharmacology (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18790892
[Journal Article] Downregulation of matrix metalloprotease-9 and urokinase plasminogen activator by TX-1877 results in decreased tumor growth and metastasis on xenograft model of rectal cancer2009
- Author(s)
  Miyake K, Shimada M, Nishioka M, Sugimoto K, Batmunkh E, Uto Y, Nagasawa H, Hori H
- Journal Title
  
  Cancer Chemother Pharmacol 64
  
  Pages: 885-892
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21791198
[Journal Article] Design of antiangiogenic hypoxic cell radiosensitizers : 2-Nitroimidazoles containing a 2-aminomethylene-4-cyclopentene-1, 3-dione moiety2008
- Author(s)
  Yoshihiro Uto
- Journal Title
  
  Bioorganic & Medicinal Chemistry 16
  
  Pages: 6042-6053
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18790892
[Journal Article] Design of antiangiogenic hypoxic cell radiosensitizers: 2-Nitroimidazoles containing a 2-aminomethylene-4-cyclopentene-1,3-dione moiety2008
- Author(s)
  Uto Y, Nagasawa H, Jin CZ, Nakayama S, Tanaka A, Kiyoi S, Nakashima H, Shimamura M, Inayama S, Fujiwara T, Takeuchi Y, Uehara Y, Kirk KL, Nakata E, Hori H,
- Journal Title
  
  Bioorganic & Medicinal Chemistry 16
  
  Pages: 6042-6053
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18790892
[Journal Article] The novel hypoxic cell radiosensitizer, TX-1877 has antitumor activity through suppression of angiogenesis and inhibits liver metastasis on xenograft model of pancreatic cancer2008
- Author(s)
  Miyake K, Shimada M, Nishioka M, Sugimoto K, Batmunkh E, Uto Y, Nagasawa H, Hori H
- Journal Title
  
  Cancer Letters 272
  
  Pages: 325-335
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18790892
[Journal Article] 解糖系代謝のエネルギー源となる単糖に対するがん細胞特異性:糖ハイブリッド低酸素細胞放射線増感剤/制癌剤の分子設計-Pharmacokinetic drug designのすすめ-2008
- Author(s)
  宇都義浩,中江崇,永澤秀子,中田栄司,堀均
- Journal Title
  
  放射線生物研究 43
  
  Pages: 68-79
- NAID
  40015940991
- Data Source
  KAKENHI-PROJECT-18790892
[Journal Article] Synthesis and biological activity of 1-methyl-tryptophan-tirapazamine hybrids as hypoxia-targeting indoleamine 2,3-dioxygenase inhibitors,2008
- Author(s)
  Nakashima H, Uto Y, Nakata E, Nagasawa H, Ikkyu K, Hiraoka N, Nakashima K, Sasaki Y, Sugimoto H, Shiro Y, Hashimoto T, Okamoto Y, Asakawa Y, Hori H
- Journal Title
  
  Bioorganic & Medicinal Chemistry 16
  
  Pages: 8661-8669
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18790892
[Journal Article] Design, synthesis, and radiosensitizing activities of sugar-hybrid hypoxic cell radiosensitizers2008
- Author(s)
  Nakae T, Uto Y, Tanaka M, Shibata H, Nakata E, Tominaga M, Maezawa H,Hashimoto T, Kirk KL, Nagasawa H, Hori H
- Journal Title
  
  Bioorganic & Medicinal Chemistry 16
  
  Pages: 675-682
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18790892
[Journal Article] Effect of molecular chirality and side chain bulkiness on angiogenesis of haloacetylcarbamoyl-2-nitroimidazole compounds2007
- Author(s)
  Ohkura K, Uto Y, Nagasawa H, Hori H
- Journal Title
  
  Anticancer Research 27
  
  Pages: 3693-3700
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18790892
[Journal Article] The role of Gc protein oligosaccharide structure as a risk factor for COPD.2006
- Author(s)
  Kazuto Ohkura
- Journal Title
  
  Anticancer Research 26・6A
  
  Pages: 4073-4078
- Data Source
  KAKENHI-PROJECT-18790892
[Journal Article] Artepillin C isoprenomics : design and synthesis of artepillin C isoprene analogues as lipid peroxidation inhibitor having low mitochondrial toxicity.2006
- Author(s)
  Yoshihiro Uto
- Journal Title
  
  Bioorganic ＆ Medicinal Chemistry 14・16
  
  Pages: 5721-5728
- Data Source
  KAKENHI-PROJECT-16659031
[Journal Article] Artepillin C isoprenomics : design and synthesis of artepillin C analogues as antiatherogenic antioxidants.2006
- Author(s)
  Yoshihiro Uto
- Journal Title
  
  Advances in Experimental Medicine and Biology 578
  
  Pages: 113-118
- Data Source
  KAKENHI-PROJECT-18790892
[Journal Article] Artepillin C isoprenomics : design and synthesis of artepillin C isoprene analogues as lipid peroxidation inhibitor having low mitochondrial toxicity.2006
- Author(s)
  Yoshihiro Uto
- Journal Title
  
  Bioorganic ＆ Medicinal Chemistry 14・16
  
  Pages: 5721-5728
- Data Source
  KAKENHI-PROJECT-18790892
[Journal Article] The role of Gc protein oligosaccharide structure as a risk factor for COPD.2006
- Author(s)
  Kazuto Ohkura
- Journal Title
  
  Anticancer Research 26・6A
  
  Pages: 4073-4078
- Data Source
  KAKENHI-PROJECT-16659031
[Journal Article] The Role of Gc Protein Oligosaccharide Structure as a Risk Factor for COPD,2006
- Author(s)
  Ohkura K, Nagasawa H, Uto Y, Okamura N, Murakami A, Hori H
- Journal Title
  
  Anticancer Research 26
  
  Pages: 4073-4078
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18790892
[Journal Article] Design of Hypoxia-Targeting Drugs as New Cancer Chemotherapeutics2006
- Author(s)
  Nagasawa H, Uto Y, Kirk KL, Hori H
- Journal Title
  
  Biological & pharmaceutical bulletin 29
  
  Pages: 2335-2342
- NAID
  110006148648
- Data Source
  KAKENHI-PROJECT-18790892
[Journal Article] Artepillin C isoprenomics : design and synthesis of artepillin C analogues as antiatherogenic antioxidants.2006
- Author(s)
  Yoshihiro Uto
- Journal Title
  
  Advances in Experimental Medicine and Biology 578
  
  Pages: 113-118
- Data Source
  KAKENHI-PROJECT-16659031
[Journal Article] Artepillin C Isoprenomics : Facile Total Synthesis and Discovery of Amphiphilic Antioxidant2005
- Author(s)
  Yoshihiro Uto
- Journal Title
  
  American Chemical Society Books (in press)
- Data Source
  KAKENHI-PROJECT-16659031
[Journal Article] Artepillin C Isoprenomics : Facile Total Synthesis and Discovery of Amphiphilic Antioxidant2005
- Author(s)
  Yoshihiro Uto
- Journal Title
  
  ACS SYMPOSIUM SERIES 909
  
  Pages: 176-187
- Data Source
  KAKENHI-PROJECT-16659031
[Journal Article] Artepillin C Isoprenomics : Facile Total Synthesis and Discovery of Amphiphilic Antioxidant2005
- Author(s)
  Yoshihiro Uto
- Journal Title
  
  American Chemical Society Books (in press)
- Data Source
  KAKENHI-PROJECT-15790671
[Journal Article] Artepillin C Isoprenomics : Facile Total Synthesis and Discovery of Amphiphilic Antioxidant2005
- Author(s)
  Yoshihiro Uto
- Journal Title
  
  ACS SYMPOSIUM SERIES 909
  
  Pages: 176-187
- Data Source
  KAKENHI-PROJECT-15790671
[Journal Article] Artepillin C Isoprenomics : Facile Total Synthesis and Discovery of Amphiphilic Antioxidant.2005
- Author(s)
  Yoshihiro Uto
- Journal Title
  
  American Chemical Society Books (in press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370758
[Patent] PDT 効果増強剤WO/2013/1870692013
- Inventor(s)
  遠藤良夫、宇都義浩、堀均、田中徹、石塚昌宏、高橋究
- Industrial Property Rights Holder
  国立大学法人金沢大学、国立大学法人徳島大学、SBIファーマ株式会社(共同出願)
- Industrial Property Rights Type
  特許
- Filing Date
  2013-06-13
- Overseas
- Data Source
  KAKENHI-PROJECT-23501305
[Presentation] Iodine-Hoechst33258の放射線増感効果と作用機序の解析2024
- Author(s)
  宇都義浩、合田萌々花、松本光太郎、富永正英、玉野井冬彦
- Organizer
  第24回菅原・大西記念癌治療増感シンポジウム
- Data Source
  KAKENHI-PROJECT-21K07567
[Presentation] 腎細胞癌免疫微小環境におけるDPP4の役割2024
- Author(s)
  Mitsuki Nishiyama、Kei Daizumoto,Minoru Matsumoto,Risa Tsuruoka,Yoshihiro Uto,Ryotaro Tomida,Yoshito Kusuhara,Tomoya Fukawa,Masayuki Takahashi,Junya Furukawa
- Organizer
  第33回泌尿器科分子・細胞研究会
- Data Source
  KAKENHI-PROJECT-23K08736
[Presentation] 鶏卵モデルを用いた免疫チェックポイント阻害剤の新規スクリーニングモデルの可能性2023
- Author(s)
  大豆本圭、宇都義浩、上原久典、西山美月、冨田諒太郎、布川朋也、高橋正幸
- Organizer
  第82回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-23K08736
[Presentation] Role of DPP4 in the immune microenvironment of renal cell carcinoma2023
- Author(s)
  Mitsuki Nishiyama、Kei Daizumoto,Minoru Matsumoto,Ria Tsuruoka,Yoshihiro Uto,Yutaro Sasaki,Yoshiteru Ueno,Ryotaro Tomida,Yoshito Kusuhara,Tomoya Fukawa,Kunihisa Yamaguchi,Yasuyo Yamamoto,Masayuki Takahashi
- Organizer
  第9回日本泌尿器腫瘍学会
- Data Source
  KAKENHI-PROJECT-23K08736
[Presentation] ABCG2阻害性チロシンキナーゼ阻害剤をリードとする5-アミノレブリン酸を用いるがん光線力学的療法に対する効果増強剤の開発2023
- Author(s)
  遠藤良夫, 宇都　義浩,　篠原　侑成,　安部　千秋, 小幡　徹,　小倉　俊一郎, 米村　豊
- Organizer
  日本薬学会第143年会（札幌、北海道大学）
- Data Source
  KAKENHI-PROJECT-21K07215
[Presentation] Development of a novel TKI derivative for enhancing the anticancer potential of 5-aminolevulinic acid-based photodynamic therapy2023
- Author(s)
  Yoshio Endo, Yoshihiro Uto, Yusei Shinohara, Chiaki Abe, Tohru Obata, Shun-ichiro Ogura, Yutaka Yonemura
- Organizer
  The 82th Annual Meeting of the Japanese Cancer Association
- Data Source
  KAKENHI-PROJECT-21K07215
[Presentation] アセチルグルコース修飾Ceritinibの放射線増感としての創薬研究2022
- Author(s)
  樫原　誉，合田萌々花，宇都義浩，山田久嗣
- Organizer
  2022年日本化学会中国四国支部大会
- Data Source
  KAKENHI-PROJECT-21K07567
[Presentation] Enhancing effect of novel Schiff base derivative combined with tyrosine kinase inhibitor on photodynamic therapy using 5-ALA.2022
- Author(s)
  Yoshio Endo, Yoshihiro Uto, Yusei Shinohara, Chiaki Abe, Tohru Obata, Shun-ichiro Ogura, Yutaka Yonemura
- Organizer
  第81回日本癌学会学術総会（横浜、パシフィコ横浜、会議センター・展示ホール）
- Data Source
  KAKENHI-PROJECT-21K07215
[Presentation] チロシンキナーゼ阻害剤を結合させた新規シッフ塩基による5-アミノレブリン酸を用いるがん光線力学的療法の効果増強2022
- Author(s)
  遠藤良夫、宇都義浩、篠原侑成、安部千秋、小幡徹、小倉俊一郎、米村豊
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-21K07215
[Presentation] Drug discovery of acetyl-glucose-modified Dasatinib as a radiosensitizer2021
- Author(s)
  中内洸希，宇都義浩
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K07567
[Presentation] 発育鶏卵を用いた患者由来の腫瘍組織移植法の検討2020
- Author(s)
  小西大輔、二若真菜、藤原由莉、折村奈美、金山博臣、上原久典、大豆本圭、宇都義浩
- Organizer
  泌尿器科分子細胞研究会
- Data Source
  KAKENHI-PROJECT-19K22689
[Presentation] 発育鶏卵を用いた患者由来がんモデルの開発2020
- Author(s)
  宇都義浩、大豆本圭、福原弥生、上原久典、金山博臣
- Organizer
  日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-19K22689
[Presentation] 医療用直線加速器の高線量率モードX線を増感する抗がん剤の探索2019
- Author(s)
  宇都義浩、羽生紋佳、楠橋由貴、二若真菜、山田久嗣、富永正英、生島仁史
- Organizer
  第25回がん治療増感研究会
- Data Source
  KAKENHI-PROJECT-17K10480
[Presentation] 放射線増感ユニットであるアセチルグルコースを修飾したEGFR阻害剤Erlotinib誘導体の創製2019
- Author(s)
  國枝由香莉、篠原侑成、田中雄也、山花啓梨、藤原由莉、山田久嗣、宇都義浩
- Organizer
  第22回菅原・大西記念癌治療増感シンポジウム
- Data Source
  KAKENHI-PROJECT-17K10480
[Presentation] リニアックの FFFビームに対する新規増感剤の創製2019
- Author(s)
  宇都義浩、小西大輔、折村奈美、山田久嗣、富永正英、生島仁史、大豆本圭、上原久典
- Organizer
  第22回菅原・大西記念癌治療増感シンポジウム
- Data Source
  KAKENHI-PROJECT-17K10480
[Presentation] アセチルグルコースを修飾した放射線増感作用を有する抗腫瘍剤の創薬研究2019
- Author(s)
  國枝由香莉、篠原侑成、田中雄也、山花啓梨、藤原由莉、山田久嗣、宇都義浩
- Organizer
  2019年日本化学会中四国支部大会
- Data Source
  KAKENHI-PROJECT-17K10480
[Presentation] Development of a Novel Acetyl Glucose-modified Gefitinib Derivative for Improvement of Radiosensitizing Effect2019
- Author(s)
  山花啓梨，篠原侑成，羽生紋佳，田中雄也，山田久嗣、宇都義浩
- Organizer
  日本化学会第99春季年会
- Data Source
  KAKENHI-PROJECT-17K10480
[Presentation] Immunologicalaspects of Improved Tumor and Normal Tissue Responses Using Biophysical modelling2018
- Author(s)
  Oita M, Udaka M, Aoyama H, Sasaki M, Tominaga M, Uto Y
- Organizer
  AAPM 2018 60th Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09998
[Presentation] Development of acetylglucose-modified gefitinib derivatives as a novel radiosensitizer2018
- Author(s)
  篠原侑成，宇都義浩
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17K10480
[Presentation] 放射線増感作用の向上を目指したアセチルグルコース修飾Gefitinib誘導体の創製2018
- Author(s)
  宇都義浩，宮本大輔，上崎里砂，羽生紋佳，二若真菜，山田久嗣
- Organizer
  第20回菅原・大西記念癌治療増感シンポジウム
- Data Source
  KAKENHI-PROJECT-17K10480
[Presentation] ウシ初乳由来マクロファージ活性化剤の創製と抗炎症作用機序の解明2017
- Author(s)
  桑田依洋，濱田健，井亀沙紀，青野ゆかり，山田久嗣，Martin Mette，久保健太郎，乾利夫，宇都義浩
- Organizer
  日本化学会第97春季年会
- Place of Presentation
  慶應義塾大学　日吉キャンパス（神奈川県横浜市）
- Year and Date
  2017-03-16
- Data Source
  KAKENHI-PROJECT-15K09998
[Presentation] Development of Sugar-modified Radiosensitizer (TX-2244) Targeting the Glycolytic Metabolism of Tumors2017
- Author(s)
  宮本大輔，篠原侑成，八重和憲，上﨑里砂，羽生紋佳，山田久嗣，富永正英，宇都義浩
- Organizer
  日本化学会第97春季年会
- Place of Presentation
  慶應義塾大学日吉キャンパス（神奈川県横浜市）
- Year and Date
  2017-03-16
- Data Source
  KAKENHI-PROJECT-26461891
[Presentation] Feasibility of dose delivery error detection by a transmission detector for patient - specific QA2017
- Author(s)
  H Honda, K Kubo, R Yamamoto, Y Ishii, H Kanzaki, Y Hamamoto, T Mochizuki, M Oita, M Sasaki, M Tominaga, Y Uto
- Organizer
  ESTRO 36
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09998
[Presentation] ５－アミノレブリン酸を用いるがん光線力学的療法に対する耐性化機構2017
- Author(s)
  遠藤良夫, 宇都義浩, 安部千秋, 小倉俊一郎, 米村豊
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台市、仙台国際センター
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-26430160
[Presentation] マクロファージ活性化因子GcMAFの貪食活性化作用に関する受容体の同定と作用機序の解明2017
- Author(s)
  桑田依洋，濱田健，井亀沙紀，青野ゆかり，山田久嗣，Martin Mette，久保健太郎，乾利夫，宇都義浩
- Organizer
  日本化学会第97春季年会
- Place of Presentation
  慶應義塾大学　日吉キャンパス（神奈川県横浜市）
- Year and Date
  2017-03-16
- Data Source
  KAKENHI-PROJECT-15K09998
[Presentation] 5-アミノレブリン酸を用いるがん光線力学的療法におけるシッフ塩基化合物による効果増強作用2016
- Author(s)
  遠藤良夫, 宇都義浩, 安部千秋, 芝一休, 小倉俊一郎, 米村豊
- Organizer
  日本薬学会第136年会
- Place of Presentation
  横浜、パシフィコ横浜
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-26430160
[Presentation] Study of Effects of Nanosecond Pulsed Electric Fields on Cancer Cell by using in Vivo and Ex Vivo Assay2016
- Author(s)
  Shun Ogura, Shuzo Matsubara, Shouta Kuniyasu, Kenji Teranishi, Yoshihiro Uto, and Naoyuki Shimomura
- Organizer
  2016 IEEE International Power Modulator and High Voltage Conference
- Place of Presentation
  San Francisco, California US
- Year and Date
  2016-07-05
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25289075
[Presentation] Does the biophysical modelling for immunological aspects in radiotherapy precisely predict tumor and normal tissue responses?2016
- Author(s)
  M.Oita, K.Nakata, H.Aoyama, M.Sasaki, M.Tominaga, H.Hoda, Y.Uto
- Organizer
  58th AAPM Annual Meeting
- Place of Presentation
  Walter E. Washington Convention Center（ワシントンDC，アメリカ合衆国）
- Year and Date
  2016-07-31
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09998
[Presentation] Application of biophysical modelling for normal tissue response with immunological aspects in radiotherapy2016
- Author(s)
  M.Oita, H.Aoyama, M.Sasaki, M.Tominaga, H.Hoda, Y.Uto
- Organizer
  International Conference on Translational Research in Radio-Oncology | Physics for Health in Europe (ICTR-PHE) 2016
- Place of Presentation
  Centre International de Conferences Geneve (CICG, ジュネーブ)
- Year and Date
  2016-02-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09998
[Presentation] 放射線増感ユニットとしてのアセチルグルコースの有用性：アセチルグルコース修飾Gefitinib誘導体の分子設計および放射線増感効果について2016
- Author(s)
  宇都　義浩，伊藤亮輔，八重和憲，宮本大輔，上崎里砂，山田久嗣，富永正英
- Organizer
  第22回癌治療増感研究会
- Place of Presentation
  沖縄県市町村自治会館（沖縄県那覇市）
- Data Source
  KAKENHI-PROJECT-26461891
[Presentation] TrueBeamを用いた低LET放射線の線量率と生物効果の相関について2016
- Author(s)
  宇都義浩, 遠藤秀彰, 八重和憲, 山田久嗣, 原毅弘, 富永正英
- Organizer
  第18回癌治療増感研究シンポジウム
- Place of Presentation
  奈良
- Year and Date
  2016-02-05
- Data Source
  KAKENHI-PROJECT-26461891
[Presentation] Activation of M2 macrophages in the late phase of cerebral ischema may contribute to phagocytosis of infract area and neurogenesis2016
- Author(s)
  Y. Kurashiki, K.T. Kitazato, K. Shimada, K. Yagi, Y. Tada, T. Kinouchi, M. Sumiyoshi, T. Miyamoto, T. Yamaguchi, J. Satomi, Y. Uto, S. Nagahiro
- Organizer
  25th European Stroke Conference
- Place of Presentation
  Italy(Venice)
- Year and Date
  2016-04-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10306
[Presentation] Activation of M2 macrophages in the late phase of cerebral ischema may contribute to phagocytosis of infract area and neurogenesis2016
- Author(s)
  Y. Kurashiki, K.T. Kitazato, K. Shimada, K. Yagi, Y. Tada, T. Kinouchi, M. Sumiyoshi, T. Miyamoto, T. Yamaguchi, J. Satomi, Y. Uto, S. Nagahiro
- Organizer
  25th European Stroke Conference
- Place of Presentation
  Venice, Italy
- Year and Date
  2016-04-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10306
[Presentation] Mechanism of acquired resistance to photodynamic therapy using 5-aminolevulinic acid.2016
- Author(s)
  Yoshio Endo, Uto Yoshihiro, Chiaki Abe, Shun-ichiro Ogura, Yutaka Yonemura
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  横浜市、パシフィコ横浜
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-26430160
[Presentation] シッフ塩基化合物 TX-816による5-アミノレブリン酸を用いるがん光線力学的療法の効果増強2015
- Author(s)
  遠藤良夫, 宇都義浩, 安部千秋, 芝一休, 小倉俊一郎, 米村豊
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸、デザイン・クリエイティブセンター神戸
- Year and Date
  2015-03-27
- Data Source
  KAKENHI-PROJECT-26430160
[Presentation] The effect of dose rate on radiation-induced in vitro antitumor activity by low-LET radiation2015
- Author(s)
  Takehiro Hara, Masahide Tominaga, Hideaki Endo and Yoshihiro Uto
- Organizer
  15th International Congress of Radiation Research
- Place of Presentation
  京都
- Year and Date
  2015-05-25
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461891
[Presentation] Investigation of Effect of Applied Nanosecond Pulsed Electric Fields on Tumor2015
- Author(s)
  Shuzo Matsubara, Akito Nakagawa, Shota Kuniyasu, Kenji Teranishi, Yoshihiro Uto, and Naoyuki Shimomura
- Organizer
  2015 IEEE Pulsed Power Conference
- Place of Presentation
  Austin, Texas US
- Year and Date
  2015-05-31
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25289075
[Presentation] Schiff base derivative TX-816 enhances the effect of photodynamic therapy using 5-aminolevulinic acid2015
- Author(s)
  Yoshio Endo, Uto Yoshihiro, Chiaki Abe, Shun-ichiro Ogura, Yutaka Yonemura, Masashi Kimura
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋、名古屋国際会議場
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-26430160
[Presentation] 超音波による癌治療に対する5-aminolevulinic acidの増感作用の検討2014
- Author(s)
  島千尋,宇都義浩,玉谷大,水木佑輔,遠藤良夫,大久保敬,中西郁夫,石塚昌宏,田中徹,口池大輔,久保健太郎,乾利夫,堀均
- Organizer
  第16回癌治療増感研究シンポジウム
- Place of Presentation
  奈良県文化会館(奈良県)
- Data Source
  KAKENHI-PROJECT-23591842
[Presentation] 超音波による癌治療に対する5-aminolevulinic acidの増感作用の検討2014
- Author(s)
  島　千尋、宇都義浩、玉谷　大、水木佑輔、遠藤良夫、大久保　敬、中西郁夫、石塚昌宏、田中　徹、口池大輔、久保健太郎、乾　利夫、堀　均
- Organizer
  第16回増感シンポジウム
- Place of Presentation
  奈良県文化会館（奈良県奈良市）
- Data Source
  KAKENHI-PROJECT-23591842
[Presentation] ナノ秒パルス電界印加による鶏卵の死亡率の検討2014
- Author(s)
  松原修三, 中川晃登, 國安翔太, 寺西研二, 下村直行, 宇都義浩
- Organizer
  平成26年度電気関係学会四国支部連合大会
- Place of Presentation
  徳島大学工学部(徳島県徳島市)
- Year and Date
  2014-09-13
- Data Source
  KAKENHI-PROJECT-25289075
[Presentation] 腫瘍移植鶏卵モデルを用いた5-aminolevulinic acid およびTin chlorin e6 の超音波増感活性の評価2014
- Author(s)
  玉谷大、宇都義浩、水木佑輔、國安翔太、野口智帆、遠藤良夫、中西郁夫、大久保敬、石塚昌宏、田中徹、口池大輔、久保健太郎、乾利夫、堀均
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本県、熊本市総合体育館
- Data Source
  KAKENHI-PROJECT-23501305
[Presentation] Enhancing efficacy of ALA-PDT by using the Schiff base derivative TX-8162014
- Author(s)
  Yoshio Endo, Uto Yoshihiro, Yutaka Yonemura, Shun-ichiro Ogura, Chiaki Abe, Masashi Kimura
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  横浜、パシフィコ横浜
- Year and Date
  2014-09-27
- Data Source
  KAKENHI-PROJECT-26430160
[Presentation] 発育鶏卵を用いたオオバギ葉抽出物の放射線防護活性の評価2013
- Author(s)
  原毅弘,宇都義浩,中島綾香,福島孝士朗,野口智帆,遠藤良夫,前澤博,富永正英,福本修一,堀均
- Organizer
  第19回癌治療増感研究会
- Place of Presentation
  東京医科歯科大学(東京都)
- Year and Date
  2013-06-08
- Data Source
  KAKENHI-PROJECT-23591842
[Presentation] 低酸素細胞放射線増感剤TX-2244のグルコース取り込み阻害と細胞内薬物動態の解析2013
- Author(s)
  笠井亮平,島千尋,宇都義浩,寺岡瑞絵,前澤博,堀均
- Organizer
  日本薬学会第133年会
- Place of Presentation
  パシフィコ横浜(神奈川県)
- Data Source
  KAKENHI-PROJECT-23591842
[Presentation] 解糖系からみた癌増感のターゲット：糖修飾放射線増感剤のメディシナルケミストリー2013
- Author(s)
  宇都義浩、他
- Organizer
  第15回癌治療増感研究シンポジウム
- Place of Presentation
  奈良市猿沢荘（奈良市）
- Data Source
  KAKENHI-PROJECT-23591842
[Presentation] 解糖系からみた癌増感のターゲット:糖修飾放射線増感剤のメディシナルケミストリー2013
- Author(s)
  宇都義浩,皆巳和賢,原田浩,遠藤良夫,前澤博,増永慎一郎,堀均
- Organizer
  第15回癌治療増感研究シンポジウム
- Place of Presentation
  猿沢荘(奈良県)
- Data Source
  KAKENHI-PROJECT-23591842
[Presentation] 発育鶏卵を用いた5-ALA の超音波増感活性の評価2013
- Author(s)
  宇都義浩, 玉谷大, 遠藤良夫, 石塚昌宏, 田中徹, 堀均
- Organizer
  第3回ポルフィリン-ALA 学会年会
- Place of Presentation
  神奈川県、東京工業大学すずかけ台キャンパスすずかけホール
- Year and Date
  2013-04-27
- Data Source
  KAKENHI-PROJECT-23501305
[Presentation] Boron tracedrug design for neutron dynamic therapeutics for Gc protein as a serum protein-quality-control treatment2013
- Author(s)
  Hitoshi Hori, Ryu Tada, Yoshihiro Uto
- Organizer
  41st Annual Meeting International Society on Oxygen Transport to Tissue
- Place of Presentation
  Dartmouth-Hitchcock Medical Center (USA)
- Data Source
  KAKENHI-PROJECT-24659566
[Presentation] Development of Immunomodulatory Cancer Therapy Based on Gc protein-derived Macrophage Activating Factor (GcMAF)2013
- Author(s)
  宇都義浩、竹内亮太、中川美典、廣田慶司、寺田　弘、鬼塚伸也、久保健太郎、口池大輔、Mette Marty、乾　利夫、遠藤良夫、堀　均
- Organizer
  第7回ナノメディシン国際シンポジウム
- Place of Presentation
  九州工業大学（福岡県北九州市）
- Invited
- Data Source
  KAKENHI-PROJECT-23591842
[Presentation] 発育鶏卵を用いたオオバギ葉抽出物の放射線防護活性の評価2013
- Author(s)
  原　毅弘、宇都義浩、中島綾香、福島孝士朗、野口智帆、遠藤良夫、前澤　博、富永正英、福本修一、堀　均
- Organizer
  第19回癌治療増感研究会
- Place of Presentation
  東京医科歯科大学（東京都文京区）
- Data Source
  KAKENHI-PROJECT-23591842
[Presentation] 発育鶏卵を用いた5-aminolevulinic acid およびTin Chlorin e6 の超音波増感活性と薬物動態の評価2013
- Author(s)
  宇都義浩,玉谷大,河井智仁,遠藤良夫,大久保敬,中西郁夫,石塚昌宏,田中徹,口池大輔,久保健太郎,乾利夫, 堀均
- Organizer
  第17回バイオ治療法研究会
- Place of Presentation
  福岡県、福岡大学病院福大メディカルホール
- Year and Date
  2013-12-07
- Data Source
  KAKENHI-PROJECT-23501305
[Presentation] Development of antimetastatic hypoxic cytotoxin TX-2137 targeting for Akt/protein kinase B2013
- Author(s)
  宇都義浩、遠藤良夫、佐藤　博、堀　　均
- Organizer
  第72回日本癌学会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Data Source
  KAKENHI-PROJECT-23591842
[Presentation] Development of Immunomodulatory Cancer Therapy Based on Gc protein-derived Macrophage Activating Factor (GcMAF)2013
- Author(s)
  宇都義浩,竹内亮太,中川美典,廣田慶司,寺田弘,鬼塚伸也,久保健太郎,口池大輔,Mette Marty,乾利夫,遠藤良夫,堀均
- Organizer
  第7回ナノメディシン国際シンポジウム
- Place of Presentation
  九州工業大学(福岡県)
- Data Source
  KAKENHI-PROJECT-23591842
[Presentation] Development of antimetastatic hypoxic cytotoxin TX-2137 targeting for Akt/protein kinase B2013
- Author(s)
  Yoshihiro Uto, Yoshio Endo, Hiroshi Sato, Hitoshi Hori
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  神奈川県、パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-23501305
[Presentation] Boron tracedrug design for neutron dynamic therapeutics for Gc protein as a serum protein-quality- control treatment2013
- Author(s)
  堀均,多田竜,宇都義浩
- Organizer
  41st Annual Meeting International Society on Oxygen Transport to Tissue
- Place of Presentation
  Dartmouth College (Hanover, NH, USA)
- Data Source
  KAKENHI-PROJECT-24659566
[Presentation] Development of antimetastatic hypoxic cytotoxin TX-2137 targeting for Akt/protein kinase B2013
- Author(s)
  宇都義浩,遠藤良夫,佐藤博,堀均
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜(神奈川県)
- Data Source
  KAKENHI-PROJECT-23591842
[Presentation] HIF-1/GFP発現系を利用した腫瘍移植鶏卵における低酸素領域の解析と放射線による分布変化の観察2012
- Author(s)
  宇都義浩,田中大地,野口智帆,原田浩,遠藤良夫,前澤博,増永慎一郎,堀均
- Organizer
  第18回癌治療増感研究会
- Place of Presentation
  大阪大学(大阪府)
- Year and Date
  2012-06-09
- Data Source
  KAKENHI-PROJECT-23591842
[Presentation] HIF-1/GFP発現系を利用した腫瘍移植鶏卵における低酸素領域の解析と放射線による分布変化の観察2012
- Author(s)
  宇都義浩、他
- Organizer
  第18回国際癌治療増感研究会
- Place of Presentation
  大阪大学銀杏会館（大阪府）
- Data Source
  KAKENHI-PROJECT-23591842
[Presentation] 腫瘍移植鶏卵における低酸素腫瘍の同定とetanidazoleのin vivo放射線増感活性の評価2012
- Author(s)
  田中大地,宇都義浩,安部千秋,遠藤良夫,前澤博,原田浩,増永慎一郎,堀均
- Organizer
  日本薬学会第132年会
- Place of Presentation
  北海道大学(北海道)
- Data Source
  KAKENHI-PROJECT-23591842
[Presentation] Boron tracedrug design for neutron dynamic therapeutics for LDL2012
- Author(s)
  堀均,中田栄司,宇都義浩
- Organizer
  40st Annual Meeting International Society on Oxygen Transport to Tissue
- Place of Presentation
  NOVOTEL (Bruges, Belgium)
- Data Source
  KAKENHI-PROJECT-24659566
[Presentation] 腫瘍移植鶏卵における低酸素腫瘍の同定とetanidazoleのin vivo放射線増感活性の評価2012
- Author(s)
  田中大地，宇都義浩，安部千秋，遠藤良夫，前澤博，原田浩，増永慎一郎，堀　均
- Organizer
  日本薬学会第132年会
- Place of Presentation
  北海道大学（北海道）
- Data Source
  KAKENHI-PROJECT-23591842
[Presentation] Evaluation of the In vivo Radiosensitizing Activity of Etanidazole Using Tumor-bearing Chick Embryo2011
- Author(s)
  安部千秋，宇都義浩，遠藤良夫，前澤博，増永慎一郎，堀　均
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場（愛知県）
- Data Source
  KAKENHI-PROJECT-23591842
[Presentation] 放射線増感活性における糖要求性からみたアセチル化グルコースハイブリッド放射線増感剤TX-2244のメディシナルケミストリー2011
- Author(s)
  宇都義浩, 中江崇, 金園剛行, 村井絵美, 佐野圭一郎, 寺岡瑞絵, 富永正英, 前澤博, 堀均
- Organizer
  第13回癌治療増感研究シンポジウム
- Place of Presentation
  奈良市
- Year and Date
  2011-02-11
- Data Source
  KAKENHI-PROJECT-21791198
[Presentation] 発育鶏卵を用いた低酸素細胞放射線増感剤およびラジカル含有ナノ粒子のin vivo評価法の開発2011
- Author(s)
  宇都義浩
- Organizer
  バイオインダストリー協会大学発・選り抜きセミナー徳島大学研究者との集い・第3回東京編(招待講演)
- Place of Presentation
  バイオインダストリー協会（東京都）
- Data Source
  KAKENHI-PROJECT-23591842
[Presentation] 発育鶏卵を用いた低酸素細胞放射線増感剤およびラジカル含有ナノ粒子のin vivo評価法の開発2011
- Author(s)
  宇都義浩
- Organizer
  バイオインダストリー協会大学発・選り抜きセミナー徳島大学研究者との集い・第3回東京編
- Place of Presentation
  バイオインダストリー協会(東京都)
- Year and Date
  2011-12-20
- Data Source
  KAKENHI-PROJECT-23591842
[Presentation] Evaluation of the In vivo Radiosensitizing Activity of Etanidazole Using Tumor-bearing Chick Embryo2011
- Author(s)
  安部千秋,宇都義浩,遠藤良夫,前澤博,増永慎一郎,堀均
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場(愛知県)
- Data Source
  KAKENHI-PROJECT-23591842
[Presentation] In vivo antioxidative activity of radical-containing-nanoparticle (RNP) in fertilized chicken egg assay2011
- Author(s)
  Uto Y, Abe C, Yoshitomi T, Nagasaki Y, Endo Y, Nakata E, Hori H
- Organizer
  International Conference on Biomaterials Science 2011
- Place of Presentation
  つくば市
- Year and Date
  2011-03-16
- Data Source
  KAKENHI-PROJECT-21791198
[Presentation] Development of an in vivo screening system for radiosensitizers and antioxidants using a chick embryo model2011
- Author(s)
  宇都義浩
- Organizer
  4th Japan-Korea Joint Symposium on Bio-microsensing Technology(招待講演)
- Place of Presentation
  九州工業大学（福岡県）
- Data Source
  KAKENHI-PROJECT-23591842
[Presentation] Development of an in vivo screening system for radiosensitizers and antioxidants using a chick embryo model2011
- Author(s)
  宇都義浩
- Organizer
  4th Japan-Korea Joint Symposium on Bio-microsensing Technology
- Place of Presentation
  九州工業大学(福岡県)
- Year and Date
  2011-10-28
- Data Source
  KAKENHI-PROJECT-23591842
[Presentation] Systems biology-based drug design of sugar-hybrid hypoxic cell radiosensitizers using the tumor-implantable chick embryo model2010
- Author(s)
  Uto Y, Abe C, Nakae T, Endo Y, Tominaga M, Maezawa H, Nakata E, Hori H
- Organizer
  PACIFICHEM 2010
- Place of Presentation
  ホノルル市
- Year and Date
  2010-12-19
- Data Source
  KAKENHI-PROJECT-21791198
[Presentation] 腫瘍移植鶏卵モデルによる糖ハイブリッド放射線増感剤のin vivo放射線増感活性の評価2010
- Author(s)
  宇都義浩, 他
- Organizer
  第16回国際癌治療増感研究会
- Place of Presentation
  県民文化ホール未来会館(岐阜)
- Year and Date
  2010-06-19
- Data Source
  KAKENHI-PROJECT-21791198
[Presentation] ストレス発育鶏卵モデルを用いたラジカル含有ナノ粒子TEMPO-RNPのin vivo抗酸化活性評価2010
- Author(s)
  宇都義浩, 安部千秋, 吉冨徹, 長崎幸夫, 遠藤良夫, 中田栄司, 堀均
- Organizer
  第63回日本酸化ストレス学会
- Place of Presentation
  横浜市
- Year and Date
  2010-06-24
- Data Source
  KAKENHI-PROJECT-21791198
[Presentation] 癌免疫療法の確立を目指したマクロファージ活性化因子(GcMAF)前駆物質GcXの創製2010
- Author(s)
  宇都義浩, 山本将太, 竹内亮太, 中川美典, 廣田慶司, 寺田弘, 鬼塚伸也, 中田栄司, 堀均
- Organizer
  第14回バイオ治療法研究会学術集会
- Place of Presentation
  福岡市
- Year and Date
  2010-12-11
- Data Source
  KAKENHI-PROJECT-21791198
[Presentation] 抗酸化剤と酸化ストレスの新しい評価法2010
- Author(s)
  宇都義浩
- Organizer
  第7回学際物質戦略イニシアチブバイオGPワークショップ
- Place of Presentation
  つくば市
- Year and Date
  2010-03-13
- Data Source
  KAKENHI-PROJECT-21791198
[Presentation] システムバイオロジー構築のためのフィチルキノールの合成と抗酸化活性評価2010
- Author(s)
  宇都義浩, 山下洋平, 田中涼, 中田栄司, 堀均
- Organizer
  第21回ビタミンE研究会
- Place of Presentation
  東京都
- Year and Date
  2010-01-22
- Data Source
  KAKENHI-PROJECT-21791198
[Presentation] Systems biology-based drug design of sugar-hybrid hypoxic cell radiosen sitizers using the tumor-implantable chick embryo model.2010
- Author(s)
  Uto Y, et al.
- Organizer
  PACIFICHEM 2010
- Place of Presentation
  ハワイコンベンションセンタ(ホノルル)
- Year and Date
  2010-12-19
- Data Source
  KAKENHI-PROJECT-21791198
[Presentation] Prenylated acylphloroglucinol derivatives : Isoprenomics-based design, syntheses and antioxidative activities2010
- Author(s)
  Uto Y, Tanaka R, Ohnaka K, Ohta Y, Yazaki K, Umemoto N, Nakata E, Hori H
- Organizer
  International Society on Oxygen Transport to Tissue 2010
- Place of Presentation
  アスコナ(スイス)
- Year and Date
  2010-07-19
- Data Source
  KAKENHI-PROJECT-21791198
[Presentation] SAR analysis of electron-rich polyyne analogues of FTY720 based on in vivo chick embryo antiangiogenic assay2010
- Author(s)
  Uto Y, Abe C, Nakata E, Hori H
- Organizer
  第69回日本癌学会学術総会
- Place of Presentation
  大阪市
- Year and Date
  2010-09-22
- Data Source
  KAKENHI-PROJECT-21791198
[Presentation] 腫瘍移植鶏卵モデルによる糖ハイブリッド放射線増感剤のin vivo放射線増感活性の評価2010
- Author(s)
  宇都義浩, 安部千秋, 中江崇, 村井絵美, 遠藤良夫, 富永正英, 前澤博, 増永慎一郎, 中田栄司, 堀均
- Organizer
  第16回国際癌治療増感研究会
- Place of Presentation
  岐阜市
- Year and Date
  2010-06-19
- Data Source
  KAKENHI-PROJECT-21791198
[Presentation] 腫瘍移植鶏卵モデルによる糖ハイブリッド低酸素細胞放射線増感剤TX-2244の腫瘍移行2009
- Author(s)
  中江崇,宇都義浩,安部千秋,新元優也,金園剛行,中島宏一郎,佐野圭一郎,富永正英,前澤博,増永慎一郎,遠藤良夫,中田栄司,堀均
- Organizer
  日本薬学会第129年会
- Data Source
  KAKENHI-PROJECT-18790892
[Presentation] 腫瘍移植鶏卵を用いて薬物動態を考慮した糖ハイブリッド放射線増感剤のドラッグデザイン2009
- Author(s)
  宇都義浩, 安部千秋, 遠藤良夫, 前澤博, 中田栄司, 堀均
- Organizer
  第68回日本癌学会学術総会
- Place of Presentation
  横浜市
- Year and Date
  2009-10-01
- Data Source
  KAKENHI-PROJECT-21791198
[Presentation] 鶏胚異種移植腫瘍モデルを基盤とした糖ハイブリッド低酸素細胞放射線増感剤の創製2009
- Author(s)
  中江崇, 宇都義浩, 安部千秋, 金園剛行, 新元優也, 佐野圭一郎, 中田栄司, 遠藤良夫, 富永正英, 前澤博, 橋本敏弘, 増永慎一郎, 堀均
- Organizer
  創薬懇話会2009
- Place of Presentation
  岐阜市
- Year and Date
  2009-12-10
- Data Source
  KAKENHI-PROJECT-21791198
[Presentation] イソプレノミクスを基盤としたプレニル化フェニルプロパノイドの分子設計と発育鶏卵を用いたin ovo抗酸化活性の評価2009
- Author(s)
  宇都義浩, 安部千秋, 山下洋平, 田中涼, 遠藤良夫, 中田栄司, 堀均
- Organizer
  第62回日本酸化ストレス学会学術集会
- Place of Presentation
  福岡市
- Year and Date
  2009-06-11
- Data Source
  KAKENHI-PROJECT-21791198
[Presentation] メチル化グルコース・糖ハイブリッド低酸素細胞放射線増感剤の分子設計2009
- Author(s)
  金園剛行,宇都義浩,中江崇,柴田明奈,中島宏一郎,佐野圭一郎,富永正英,前澤博,中田栄司,堀均
- Organizer
  日本薬学会第129年会
- Place of Presentation
  京都市
- Data Source
  KAKENHI-PROJECT-18790892
[Presentation] Pharmacokinetic drug design of sugar-hybrid radiosensitizers using the tumor implant chick embryo model2009
- Author(s)
  宇都義浩
- Organizer
  第68回日本癌学会学術総会
- Place of Presentation
  横浜市
- Year and Date
  2009-10-02
- Data Source
  KAKENHI-PROJECT-21791198
[Presentation] 腫瘍移植鶏卵を用いたin ovo放射線増感活性評価系の確立2009
- Author(s)
  新元優也,宇都義浩,遠藤良夫,安部千秋,中島宏一郎,佐野圭一郎,佐々木有紀,皆巳和賢,前澤博,増永慎一郎,中田栄司,堀均
- Organizer
  日本薬学会第129年会
- Place of Presentation
  京都市
- Data Source
  KAKENHI-PROJECT-18790892
[Presentation] 腫瘍移植鶏卵モデルによる糖ハイブリッド放射線増感剤の薬物動態解析2009
- Author(s)
  宇都義浩, 中江崇, 安部千秋, 新元優也, 佐野圭一郎, 遠藤良夫, 富永正英, 前澤博, 中田栄司, 堀均
- Organizer
  第15回国際癌治療増感研究会
- Place of Presentation
  京都市
- Year and Date
  2009-06-20
- Data Source
  KAKENHI-PROJECT-21791198
[Presentation] マクロファージ活性化に関わるGalNAcの結合様式2009
- Author(s)
  辻祐亮,宇都義浩,中田栄司,永澤秀子,河野悠介,藤田秀司,千葉一裕,堀均
- Organizer
  日本薬学会第129年会
- Place of Presentation
  京都市
- Data Source
  KAKENHI-PROJECT-18790892
[Presentation] 腫瘍移植鶏卵を用いたin ovo放射線増感活性評価系の確立2009
- Author(s)
  宇都義浩,安部千秋,新元優也,中江崇,中島宏一郎,佐野圭一郎,遠藤良夫,皆巳和賢,前澤博,増永慎一郎,中田栄司,堀均
- Organizer
  第11回癌治療増感研究シンポジウム
- Place of Presentation
  奈良市
- Data Source
  KAKENHI-PROJECT-18790892
[Presentation] ニトロイミダゾールアセトアミド誘導体による低酸素放射線増感効果2008
- Author(s)
  皆巳和賢,宇都義浩,中江崇,中田栄司,永澤秀子,堀均,前澤博
- Organizer
  第10回癌治療増感研究シンポジウム
- Place of Presentation
  奈良市
- Data Source
  KAKENHI-PROJECT-18790892
[Presentation] 2-アミノメチレン-4-シクロペンテン-1,3-ジオン構造を有する抗血管新生低酸素細胞放射線増感剤の創製2008
- Author(s)
  堀均,宇都義浩,永澤秀子,島村真里子,稲山誠一,上原至雅
- Organizer
  第67回日本癌学会学術総会
- Place of Presentation
  名古屋市
- Data Source
  KAKENHI-PROJECT-18790892
[Presentation] 低酸素細胞に対するニトロイミダゾールアセトアミド誘導体の放射線増感効果2008
- Author(s)
  皆巳和賢,宇都義浩,中江崇,中田栄司,永澤秀子,堀均,前澤博
- Organizer
  第47回日本医学放射線学会生物部会学術大会
- Place of Presentation
  高知市
- Data Source
  KAKENHI-PROJECT-18790892
[Presentation] がんによるグルコースの高い取り込みを利用した糖ハイブリッド低酸素細胞放射線増感剤の分子設計2008
- Author(s)
  中島宏一郎,中江崇,柴田明奈,田中智子,宇都義浩,富永正英,前澤博,中田栄司,永澤秀子,堀均
- Organizer
  日本薬学会第128年会
- Place of Presentation
  横浜市
- Data Source
  KAKENHI-PROJECT-18790892
[Presentation] マクロファージ活性化因子GcMAFの糖鎖構造部位をミミックしたGalNAc-Thrデンドリマーの分子設計2008
- Author(s)
  柴田明奈,中江崇,滝口公康,宇都義浩,中田栄司,永澤秀子,堀均
- Organizer
  日本薬学会第128年会
- Place of Presentation
  横浜市
- Data Source
  KAKENHI-PROJECT-18790892
[Presentation] 腫瘍移植鶏卵を用いたin vivo放射線増感活性評価モデルの開発2008
- Author(s)
  宇都義浩,遠藤良夫,前澤博,永澤秀子,堀均
- Organizer
  第67回日本癌学会学術総会,
- Data Source
  KAKENHI-PROJECT-18790892
[Presentation] 次世代動物実験系としての腫瘍移植鶏卵の構築と放射線照射による腫瘍成長阻害活性2008
- Author(s)
  宇都義浩,中江崇,佐々木有紀,安部千秋,中島宏一郎,新元優也,佐野圭一郎,遠藤良夫,皆巳和賢,前澤博,中田栄司,永澤秀子,堀均,
- Organizer
  第14回癌治療増感研究会
- Place of Presentation
  鈴鹿市
- Data Source
  KAKENHI-PROJECT-18790892
[Presentation] 直腸癌に対する低酸素細胞放射線増感剤TX-1877の放射線増感作用と抗腫瘍効果に関する基礎的研究2007
- Author(s)
  三宅講太朗,西岡将規,杉本光司,宮谷知彦,宇都義浩,永澤秀子,堀均,島田光生
- Organizer
  第66回日本癌学会学術総会
- Place of Presentation
  横浜市
- Data Source
  KAKENHI-PROJECT-18790892
[Presentation] 解糖系基質と低酸素細胞放射線増感剤のハイブリッド分子設計2007
- Author(s)
  宇都義浩
- Organizer
  第66回日本癌学会学術総会
- Place of Presentation
  横浜市パシフイコ横浜
- Year and Date
  2007-10-04
- Data Source
  KAKENHI-PROJECT-18790892
[Presentation] 低酸素腫瘍移行性糖ハイブリッド放射線増感剤の創製2007
- Author(s)
  田中智子,宇都義浩,富永正英,中江崇,村上綾,永澤秀子,堀均
- Organizer
  第9回癌治療増感研究シンポジウム
- Place of Presentation
  奈良市
- Data Source
  KAKENHI-PROJECT-18790892
[Presentation] 解糖系基質と低酸素細胞放射線増感剤のハイブリッド分子設計2007
- Author(s)
  宇都義浩,堀均,永澤秀子
- Organizer
  第66回日本癌学会学術総会
- Place of Presentation
  横浜市
- Data Source
  KAKENHI-PROJECT-18790892
[Presentation] 低酸素がん選択的ハイブリッド型放射線増感剤の創製2007
- Author(s)
  宇都義浩,富永正英,中江崇,田中智子,村上綾,佐々木有紀,柴田明奈,中島宏一郎,中田栄司,永澤秀子,堀均
- Organizer
  第13回癌治療増感研究会
- Place of Presentation
  前橋市
- Data Source
  KAKENHI-PROJECT-18790892
[Presentation] Non-secosteroidal Vitamin D mimicを用いたGc-Proteinのアフィニティーカラムの作成2007
- Author(s)
  荒井健,宇都義浩,岡村菜摘子,滝口公康,村上綾,永澤秀子,堀均
- Organizer
  第127年会日本薬学会
- Place of Presentation
  富山市
- Data Source
  KAKENHI-PROJECT-18790892
[Presentation] マクロファージ活性化に関わるGc proteinの糖ペプチド構造解析2007
- Author(s)
  滝口公康,荒井健,辻祐亮,永澤秀子,宇都義浩,中田栄司,鬼塚伸也,野中孝一,藤岡ひかる,堀均
- Organizer
  第11回バイオ治療法研究会学術集会
- Place of Presentation
  福岡市
- Data Source
  KAKENHI-PROJECT-18790892
[Presentation] 膵臓癌に対する低酸素細胞放射線増感剤TX-1877誘導体の放射線増感作用と抗腫瘍効果に関する基礎的研究2006
- Author(s)
  三宅講太朗,西岡将規,永澤秀子,宇都義浩,堀均,島田光生
- Organizer
  第65回日本癌学会学術総会
- Place of Presentation
  横浜市
- Data Source
  KAKENHI-PROJECT-18790892
[Presentation] 細胞表面を構成するsugar scaffoldに基づくハイブリッド型低酸素細胞放射線増感剤の創製2006
- Author(s)
  中江崇,宇都義浩,村綾,田中彩子,堀均,永澤秀子
- Organizer
  第4回次世代を担う有機化学シンポジウム
- Place of Presentation
  大阪市
- Data Source
  KAKENHI-PROJECT-18790892
[Presentation] 多機能性糖タンパク質Gc protein及びその糖ペプチドの構造解析2006
- Author(s)
  滝口公康,宇都義浩,岡村菜摘子,村上綾,永澤秀子,鬼塚伸也,野中孝一,藤岡ひかる,堀均
- Organizer
  第10回バイオ治療法研究会学術集会
- Place of Presentation
  東京都
- Data Source
  KAKENHI-PROJECT-18790892
[Presentation] マクロファージ活性化能を有する糖ハイブリッド低酸素細胞放射線増感剤の創製2006
- Author(s)
  宇都義浩,永澤秀子,堀均
- Organizer
  第65回日本癌学会学術総会
- Place of Presentation
  横浜市
- Data Source
  KAKENHI-PROJECT-18790892
[Presentation] Effects of Applied Ultrashort Pulsed Electric Fields on Solid Tumor
- Author(s)
  Akito Nakagawa, Masataka Nagahama, Kenji Teranishi, Yoshihiro Uto, and Naoyuki Shimomura
- Organizer
  2014 IEEE International Power Modulator and High Voltage Conference
- Place of Presentation
  Santa Fe Convention Center(NM, USA)
- Year and Date
  2014-06-01 – 2014-06-05
- Data Source
  KAKENHI-PROJECT-25289075
[Presentation] EFFECT OF APPLIED NANOSECOND PULSED ELECTRIC FIELDS ON TUMOR CELLS
- Author(s)
  Shuzo Matsubara, Akito Nakagawa, Shouta Kuniyasu, Youhei Kawasaki,Kenji Teranishi, Yoshihiro Uto and Naoyuki Shimomura
- Organizer
  20th IEEE Pulsed Power Conference
- Place of Presentation
  Hilton Austin Hotel(TX, USA)
- Year and Date
  2015-05-31 – 2015-06-04
- Data Source
  KAKENHI-PROJECT-25289075
[Presentation] 極短パルス電界の固形腫瘍への効果に関する研究
- Author(s)
  中川晃登, 永濱匡高, 寺西研二, 宇都義浩, 下村直行
- Organizer
  平成25年度電気関係学会四国支部連合大会
- Place of Presentation
  徳島大学（徳島県）
- Data Source
  KAKENHI-PROJECT-25289075
[Presentation] 発育鶏卵を用いた5-ALAの超音波増感活性の評価
- Author(s)
  宇都義浩, 玉谷　大, 遠藤良夫, 石塚昌宏, 田中　徹, 堀　均
- Organizer
  第3回ポルフィリン-ALA学会年会
- Place of Presentation
  横浜、東京工業大学　すずかけ台キャンパス　すずかけホール
- Data Source
  KAKENHI-PROJECT-23501305

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uto yoshihiro 宇都 義浩

UTO Yoshihiro 宇都 義浩

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アセチルグルコース修飾スルファサラジンの分子設計・合成と放射線増感作用の評価Principal Investigator

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Design and synthesis of acetylglucose-modified dasatinib and evaluation of radiosensitizing effectPrincipal Investigator

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Elucidation of radiosensitization mechanism of acetylglucose-modified gefitinib and development of novel radiosensitizerPrincipal Investigator

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Development of radiosensitizers based on antitumor/molecular targeted drugs modified by acetylglucosePrincipal Investigator

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uto yoshihiro 宇都義浩

UTO Yoshihiro 宇都義浩