Matsukawa Noriyuki 松川則之

Researcher Number	20305543
Other IDs	https://orcid.org/0000-0002-6638-4516
Affiliation (Current)	2025: 名古屋市立大学, 医薬学総合研究院(医学), 教授
Affiliation (based on the past Project Information) *help	2019 – 2024: 名古屋市立大学, 医薬学総合研究院(医学), 教授 2016 – 2018: 名古屋市立大学, 大学院医学研究科, 教授 2015: 名古屋市立大学, 医学部, 教授 2013 – 2015: 名古屋市立大学, 医学(系)研究科(研究院), 教授
Review Section/Research Field	Principal Investigator Basic Section 52020:Neurology-related / Neurology / Psychiatric science Except Principal Investigator Basic Section 59010:Rehabilitation science-related / Basic Section 51030:Pathophysiologic neuroscience-related / Basic Section 58080:Gerontological nursing and community health nursing-related / Neurochemistry/Neuropharmacology / Orthopaedic surgery
Keywords	Principal Investigator HCNP / ＨＣＮＰ / コリン作動性神経 / Ach / 受容体 / アルツハイマー病 / Aβオリゴマー / A beta / hippocampus / acetylcholine … More / 海馬神経活動 / 認知予備能 / 認知機能障害 / 前駆体蛋白 / リン酸化 / HCNP前駆体 / 顆粒空胞変性 / 平野小体 … More Except Principal Investigator ウイルス二重感染法 / 赤核 / 小脳 / DeepLabCut / マーカーレス / ラット / 上肢リーチ運動 / 内包出血モデル / Deep Lab Cut / 上肢巧緻機能 / 脳内出血 / リハビリテーション / 小脳赤核路 / 分化誘導 / ノックアウト / RKIP / 脳梗塞 / 神経幹細胞 / コンディショナルノックアウト / 海馬コリン作動性神経刺激ペプチド / Rafキナーゼ阻害蛋白 / 神経再生 / ”歩行波” / フレイル / センサーチップ / ”なごやどえりゃー体操” / 転倒予防 / 3次元加速度計 / 転倒予防体操 / フレイル予防 / 歩行波 / アンクルウェイト / 神経病理 / 鼻粘膜 / 診断 / 認知症 / アルツハイマー病 / 脳神経疾患 / 低侵襲化 / MRI / 成人脊柱変形 / 低侵襲手術 / パーキンソン病 / 脊柱配列 / 頚椎後弯変形 / 低侵襲脊椎手術 / 脊柱変形 Less

Analysis of motor regulatory system in the recovery of forelimb function by forced-limb use after intracerebral hemorrhage
- Principal Investigator
  
  飛田秀樹
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 59010:Rehabilitation science-related
- Research Institution
  Nagoya City University
Creating a fall prevention program that the elderly can evaluate their walk-style by developing our three-dimensional acceleration sensor
- Principal Investigator
  
  Akatsu Hiroyasu
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 58080:Gerontological nursing and community health nursing-related
- Research Institution
  Nagoya City University
Purification of HCNP receptor for new drug developmentPrincipal Investigator
- Principal Investigator
  
  Matsukawa Noriyuki
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Nagoya City University
脳虚血後の内在性神経幹細胞分化誘導～がん抑制因子RKIPを介して
- Principal Investigator
  
  豊田剛成
- Project Period (FY)
  2019 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Nagoya City University
The resolution of molecular mechanism on connitive reserve by HCNP functionPrincipal Investigator
- Principal Investigator
  
  Matsukawa Noriyuki
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Nagoya City University
multidisciplinary analysis for severe spinal deformity including cervical kyphosis
- Principal Investigator
  
  Mizutani Jun
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Nagoya City University
Determinations of nasal biomarkers for dementia and development of a novel diagnostic method for Alzheimer's disease using nasal samples.
- Principal Investigator
  
  Tooyama Ikuo
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Shiga University of Medical Science
The involvemnt of HCNP precursor in formation of hirano body and granulovascuolar degenerationPrincipal Investigator
- Principal Investigator
  
  Matsukawa Noriyuki
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Psychiatric science
- Research Institution
  Nagoya City University

All 2021 2020 2019 2017 2016 2015 2014 Other

All Journal Article Presentation Patent

[Journal Article] Reduction of acetylcholine ion the hippocampus of hippocampus cholinergic neurostimulating peptide precursor protein knockout mice2021
- Author(s)
  Kondo-Takuma Y, Mizuno M, Tsuda Y, madokoro Y, Suzuki K, Sato T, takase H, Uchida Y, Adachi KI, Hida H, Borlongan CV, Matsukawa N.
- Journal Title
  
  Sci Rep
  
  Volume: 11(1) Issue: 1
- DOI
  10.1038/s41598-021-01667-8
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07882, KAKENHI-PROJECT-19K16922, KAKENHI-PROJECT-20K07891
[Journal Article] Impairment of the visuospatial working memory in the patients with Parkinson's Disease: an fMRI study.2021
- Author(s)
  Kawashima S, Shimizu Y, Ueki Y, Matsukawa N.
- Journal Title
  
  BMC Neurol.
  
  Volume: 21(1) Issue: 1 Pages: 335-335
- DOI
  10.1186/s12883-021-02366-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K11351, KAKENHI-PROJECT-20K07891
[Journal Article] Possible correlated variation of GABA A receptor α3 expression with hippocampal cholinergic neurostimulating peptide precursor protein in the hippocampus2021
- Author(s)
  Adachi K, Matsukawa N et al.
- Journal Title
  
  Biochem Biophys Res Commun .
  
  Volume: 542 Pages: 80-86
- DOI
  10.1016/j.bbrc.2021.01.010
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07891, KAKENHI-PROJECT-19K16922
[Journal Article] Rapid Progression of White Matter Signal Changes and Frontotemporal Atrophy in Globular Glial Tauopathy2021
- Author(s)
  Ohno Y, Matsukawa N et al.
- Journal Title
  
  J Neuropathol Exp Neurol .
  
  Volume: 80(5) Issue: 5 Pages: 480-483
- DOI
  10.1093/jnen/nlaa151
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07891
[Journal Article] The Feasibility of Mechanical Thrombectomy on Single-Plane Angiosuite: An In-Depth Analysis of Procedure Time2021
- Author(s)
  Inoue H, Oomura M, Nishikawa Y, Mase M, Matsukawa N.
- Journal Title
  
  Cerebrovasc Dis Extra.
  
  Volume: 11 Issue: 3 Pages: 112-117
- DOI
  10.1159/000519555
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07891, KAKENHI-PROJECT-17K16657
[Journal Article] The unsolved mystery of hippocampal cholinergic neurostimulating peptide: A potent cholinergic regulator2021
- Author(s)
  Justin Y Cho, Noriyuki Matsukawa
- Journal Title
  
  Brain Circ.
  
  Volume: 7 Issue: 1 Pages: 29-32
- DOI
  10.4103/bc.bc_14_21
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07891
[Journal Article] Corticobasal syndrome-Pick's disease: A clinicopathological study2020
- Author(s)
  Uchida Y, Yoshida M, Takada K, Tsugu Y, Ueki Y, Matsukawa N.
- Journal Title
  
  J Neurol Sci
  
  Volume: 412 Pages: 116752-116752
- DOI
  10.1016/j.jns.2020.116752
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K11351, KAKENHI-PROJECT-17K09761, KAKENHI-PLANNED-16H06402
[Journal Article] Iron leakage owing to blood?brain barrier disruption in small vessel disease CADASIL2020
- Author(s)
  Uchida Yuto、Kan Hirohito、Sakurai Keita、Arai Nobuyuki、Inui Shohei、Kobayashi Susumu、Kato Daisuke、Ueki Yoshino、Matsukawa Noriyuki
- Journal Title
  
  Neurology
  
  Volume: 95 Issue: 9
- DOI
  10.1212/wnl.0000000000010148
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K11351, KAKENHI-PROJECT-20K07891, KAKENHI-PROJECT-19K17148, KAKENHI-PLANNED-16H06402, KAKENHI-PROJECT-17K15805, KAKENHI-PROJECT-19H01091
[Journal Article] Correlating diffusion-weighted MRI intensity with type 2 pathology in mixed MM-type sporadic Creutzfeldt-Jakob disease.2020
- Author(s)
  Ikeda T, Iwasaki Y, Sakurai K, Akagi A, Riku Y, Mimuro M, Miyahara H, Kitamoto T, Matsukawa N, Yoshida M.
- Journal Title
  
  J Neurol Sci.
  
  Volume: 408 Pages: 116515-116515
- DOI
  10.1016/j.jns.2019.116515
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09761, KAKENHI-PROJECT-19KK0213, KAKENHI-PROJECT-18H02738, KAKENHI-PROJECT-19K22588
[Journal Article] Magnetic Susceptibility Associates with Dopaminergic Deficits and Cognition in Parkinson's Disease.2020
- Author(s)
  Uchida Y, Kan H, Sakurai K, Inui S, Kobayashi S, Akagawa Y, Shibuya K, Ueki Y, Matsukawa N.
- Journal Title
  
  Mov Disord
  
  Volume: in press Issue: 8 Pages: 1396-1405
- DOI
  10.1002/mds.28077
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K11351, KAKENHI-PROJECT-20K07891, KAKENHI-PROJECT-19K17148, KAKENHI-PLANNED-16H06402, KAKENHI-PROJECT-17K15805, KAKENHI-PROJECT-19H01091
[Journal Article] Anatomical Links between White Matter Hyperintensity and Medial Temporal Atrophy Reveal Impairment of Executive Functions.2019
- Author(s)
  Yamanaka T, Uchida Y, Sakurai K, Kato D, Mizuno M, Sato T, Madokoro Y, Kondo Y, Suzuki A, Ueki Y, Ishii F, Borlongan CV, Matsukawa N
- Journal Title
  
  Aging Dis.
  
  Volume: 10(4) Issue: 4 Pages: 711-718
- DOI
  10.14336/ad.2018.0929
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K11351, KAKENHI-PROJECT-17K09761
[Journal Article] Reduced Cholinergic Activity in the Hippocampus of Hippocampal Cholinergic Neurostimulating Peptide Precursor Protein Knockout Mice.2019
- Author(s)
  Madokoro Y, Yoshino Y, Kato D, Sato T, Mizuno M, Kanamori T, Shimazawa M, Hida H, Hara H, Yoshida M, Borlongan CV, Ojika K, Matsukawa N.
- Journal Title
  
  Int J Mol Sci.
  
  Volume: 20(21) Issue: 21 Pages: 1-17
- DOI
  10.3390/ijms20215367
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07882, KAKENHI-PROJECT-17K09761
[Journal Article] Nigrostriatal Dopaminergic Dysfunction And Altered Functional Connectivity In REM Sleep Behaviour Disorder With Mild Motor Impairment2019
- Author(s)
  Yamada G, Ueki Y, Oishi N, Oguri T, Fukui A, Nakayama M, Kandori A, Sano Y, Kan H, Arai N, Sakurai K, Wada I, Matsukawa N
- Journal Title
  
  Front. Neurol.
  
  Volume: 10 Pages: 802-802
- DOI
  10.3389/fneur.2019.00802
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07712, KAKENHI-PROJECT-19K11351, KAKENHI-PROJECT-19K17015, KAKENHI-PLANNED-16H06402, KAKENHI-PROJECT-17K09761
[Journal Article] Hippocampal Cholinergic Neurostimulating Peptide as a Possible Modulating Factor against Glutamatergic Neuronal Disability by Amyloid Oligomers.2017
- Author(s)
  Sato T, Ohi Y, Kato D, Mizuno M, Takase H, Kanamori T, Borlongan CV, Haji A, Matsukawa N
- Journal Title
  
  Cell transplantation
  
  Volume: 26 Issue: 9 Pages: 1542-1550
- DOI
  10.1177/0963689717721232
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09761
[Journal Article] Two brothers homozygous for the TTR V30M both presenting with a phenotype dominated by central nervous complications.2016
- Author(s)
  Uchida Y, Takada K, Tsugu Y, Yamashita T, Ando Y, Kobayashi S, Koike H, Watanabe T, Matsumoto T, Toyoda T, Yamada G, Matsukawa N
- Journal Title
  
  Amyloid
  
  Volume: ２２（４） Pages: 261-2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461777
[Journal Article] Blood-based diagnosis of Alzheimer's disease using fingerprinting metabolomics based on hydrophilic interaction liquid chromatography with mass spectrometry and multivariate statistical analysis2015
- Author(s)
  Koichi Inoue, Hirofumi Tsuchiya, Takahiro Takayama, Hiroyasu Akatsu,Yoshio Hashizume, Takayuki Yamamoto, Noriyuki Matsukawa, Toshimasa Toyo'oka
- Journal Title
  
  Journal of Chromatography B
  
  Volume: 974 Pages: 24-34
- DOI
  10.1016/j.jchromb.2014.10.022
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24590055, KAKENHI-PROJECT-24590061, KAKENHI-PROJECT-25461777
[Journal Article] Simultaneous determination of post-translational racemization and isomerization of N-terminal amyloid-β in Alzheimer's brain tissue by covalent chiral derivatized ultraperformance liquid chromatography tandem mass spectrometry2014
- Author(s)
  Inoue K, Hosaka D, Mochizuki N, Akatsu H, Tsutsumiuchi K, Hashizume Y, Matsukawa N, Yamamoto T, Toyo'oka T
- Journal Title
  
  Anal Chem
  
  Volume: 86(1) Pages: 797-804
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461777
[Journal Article] Comparison of effects of valsartan and amlodipine on cognitive functions and auditory p300 event-related potentials in elderly hypertensive patients2014
- Author(s)
  Katada E, Uematsu N, Takuma Y, Matsukawa N
- Journal Title
  
  Clin Neuropharmacol
  
  Volume: 37(5) Issue: 5 Pages: 129-132
- DOI
  10.1097/wnf.0000000000000042
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461777
[Patent] 遺伝子改変非ヒト動物及びその作製方法2019
- Inventor(s)
  松川則之
- Industrial Property Rights Holder
  松川則之
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2019-084543
- Filing Date
  2019
- Data Source
  KAKENHI-PROJECT-17K09761
[Presentation] 質量分析装置によるアルツハイマー病患者脳中におけるリン酸化HCNPの微量解析
- Author(s)
  松川則之
- Organizer
  認知症学会
- Place of Presentation
  長野県松本文化会館（松本）
- Data Source
  KAKENHI-PROJECT-25461777

1. AKATSU Hiroyyasu (00399734)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
2. INOUE Koichi (30339519)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
3. Mizutani Jun (70326156)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. Tooyama Ikuo (20207533)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. Shimizu Shino (50505592)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. Michikawa Makoto (40270912)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 大塚隆信 (10185316)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 鈴木伸幸 (50551230)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 植木美乃 (40467478)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
10. 梅村淳 (00244567)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 正木克由規 (00365652)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 村上里奈 (10535818)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 明石惠子 (20231805)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 鈴木匡 (20555081)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 渡邊航平 (20630990)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 川出義浩 (20738439)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 望月直樹 (30311426)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 間辺利江 (50723110)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 加藤昇平 (70311032)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 山口知香枝 (70514066)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 大原弘隆 (80285212)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 豊田剛成 (80624014)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 飛田秀樹 (00305525)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
24. 小林憲太 (70315662)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. TOYOOKA Toshimasa

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
26. OISHI Naoya

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Matsukawa Noriyuki 松川 則之

Research Projects

Research Products

Co-Researchers

Analysis of motor regulatory system in the recovery of forelimb function by forced-limb use after intracerebral hemorrhage

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Creating a fall prevention program that the elderly can evaluate their walk-style by developing our three-dimensional acceleration sensor

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Purification of HCNP receptor for new drug developmentPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

脳虚血後の内在性神経幹細胞分化誘導～がん抑制因子RKIPを介して

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The resolution of molecular mechanism on connitive reserve by HCNP functionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

multidisciplinary analysis for severe spinal deformity including cervical kyphosis

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Determinations of nasal biomarkers for dementia and development of a novel diagnostic method for Alzheimer's disease using nasal samples.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The involvemnt of HCNP precursor in formation of hirano body and granulovascuolar degenerationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Reduction of acetylcholine ion the hippocampus of hippocampus cholinergic neurostimulating peptide precursor protein knockout mice2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Impairment of the visuospatial working memory in the patients with Parkinson's Disease: an fMRI study.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Possible correlated variation of GABA A receptor α3 expression with hippocampal cholinergic neurostimulating peptide precursor protein in the hippocampus2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Rapid Progression of White Matter Signal Changes and Frontotemporal Atrophy in Globular Glial Tauopathy2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The Feasibility of Mechanical Thrombectomy on Single-Plane Angiosuite: An In-Depth Analysis of Procedure Time2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The unsolved mystery of hippocampal cholinergic neurostimulating peptide: A potent cholinergic regulator2021

Author(s)

Journal Title

Matsukawa Noriyuki 松川則之