YAMASHITA Hiroshi 山下拓史

… Alternative Names

山下拓史ヤマシタヒロシ

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Researcher Number	20311813
External Links
Affiliation (based on the past Project Information) *help	2010: 広島大学, 病院, 講師 2008: 広島大学, 病院, 講師 2002 – 2005: 広島大学, 大学院・医歯薬学総合研究科, 助手 2003: Hiroshima University, Graduate School of Biomedical Sciences, Research Associate, 大学院・医歯薬総合研究科, 助手 1999 – 2001: 広島大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Neurology / Biological Sciences / Neurology / Neurochemistry/Neuropharmacology Except Principal Investigator Neurology / Neurology
Keywords	Principal Investigator α-synuclein / Fyn / protein tyrosine kinase / Synphilin-1 / SIAH / Parkin / Lewy小体 / パーキンソン病 / ニトロ化 / Pyk2 … More / チロシンリン酸化 / Parkinson病 / protein / gene / neuroscience / neurological disorder / 蛋白質 / 遺伝子 / 神経科学 / 脳神経疾患 / Lewy body / ubiquitin lipase / ubiquitination / Parkinson's disease / ドーパミン / ユビキチン / Siah-1 / α-Synuclein / ユビキチン化 / ユビキチンリガーゼ / synphilin-1 / Peroxynitrite / 重合 / Src family knase / RAFTK / c-Src / tyrosine 125 / phosphorylation / 凝集体形成 / SH-SY5Y細胞 / Protein tyrosine kinase / Golgi装置 / SH3ドメイン / PAP-1 / yeast two-hybrid system / MAP kinase / G蛋白共役型受容体 / PYK2 … More Except Principal Investigator neural stem cell / ischemia / neurogenesis / ノックアウトマウス / 脳梗塞 / シクロオキシゲナーゼ / 海馬 / 神経幹細胞 / 脳虚血 / 神経細胞新生 / 脳神経疾患 / cerebral infarction / ischemic stroke / Neurogenesis / 循環器・高血圧 / 再生医学 / 神経科学 / Musashi1 / Cyclooxygenase-2 / subgranular zone / dentate gyrus / hippocampus / 顆粒下層 / 歯状回 / 動物モデル / 虚血性脳損傷 / 移植・再生医療 / ナトリウム / グルタミン酸輸送蛋白 / L-2-(carboxycyclopropyl)-glycine / グルタミン酸 / 神経細胞死 / 神経変性疾患 / パーキンソン病 / アルツハイマー病 Less

Optimal therapeutic approach on ischemic brain insult using bone marrow stromal cells cultured under simulated microgravity
- Principal Investigator
  
  MATSUMOTO Masayasu
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurology
- Research Institution
  Hiroshima University
Analysis on aggregation formation by novel Lewy body component Siah-1 complementary to ParkinPrincipal Investigator
- Principal Investigator
  
  TAKAHASHI Tetsuya, 山下拓史
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Hiroshima University
OPTIMAL REGULATION OF NEUROGENESIS AND NEURAL STEM CELLS FOR THE TREATMENT OF ISCHEMIC CEREBROVASCULAR DISEASE
- Principal Investigator
  
  MATSUMOTO Masayasu
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurology
- Research Institution
  HIROSHIMA UNIVERSITY
IDENTIFICATION AND CHARACTERIZATION OF A NOVEL UBIQUITIN LIGASE SIAH THAT EXHIBITS COMPLEMENTARY ROLES WITH PARKINPrincipal Investigator
- Principal Investigator
  
  YAMASHITA Hiroshi
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  HIROSHIMA UNIVERSITY
CLINICAL APPLICATIONS OF NEUROGENESIS FOR THE TREATMENT OF ISCHEMIC CEREBROVASCULAR DISEASE
- Principal Investigator
  
  MATSUMOTO Masayuki
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurology
- Research Institution
  HIROSHIMA UNIVERSITY
α-synucleinキナーゼの同定とα-synuclein凝集機序の解析Principal Investigator
- Principal Investigator
  
  山下拓史
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Hiroshima University
α-synucleinの凝集過程におけるα-synucleinキナーゼの役割Principal Investigator
- Principal Investigator
  
  山下拓史
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurology
- Research Institution
  Hiroshima University
神経細胞死予防のためのグルタミン酸・ドーパミン輸送蛋白の研究
- Principal Investigator
  
  中村重信
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Hiroshima University
α-synucleinキナーゼの同定とα-syuclein凝集機序の解析Principal Investigator
- Principal Investigator
  
  山下拓史
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Hiroshima University
神経細胞におけるG蛋白共役型受容体からPYK2を介したシグナル伝達経路の解析Principal Investigator
- Principal Investigator
  
  山下拓史
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Hiroshima University

All 2008 2006 2004

All Journal Article

[Journal Article] White matter lesions in the brain with frontotemporal lobar degeneration with motor neuron disease : TDP-43-immunopositive inclusions co-localize with p62, but not ubiquitin.2008
- Author(s)
  Hiji M, Takahashi T, Fukuba H, Yamashita H, Kohriyama T, Matsumoto M.
- Journal Title
  
  Acta Neuropathol. 116
  
  Pages: 183-191
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390246
[Journal Article] Synphilin-1 transgenic mice exhibit mild motor impairments.2008
- Author(s)
  Jin HG, Yamashita H, Nakamura T, Fukuba H, Takahashi T, Hiji M, Kohriyama T, Matsumoto M.
- Journal Title
  
  Neurosci Lett. 445
  
  Pages: 12-17
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390246
[Journal Article] Embryonic stem cell-derived neuron models of Parkinson's disease exhibit delayed neuronal death2006
- Author(s)
  Yamashita H, et al.
- Journal Title
  
  J Neurochem in press
- Data Source
  KAKENHI-PROJECT-17590880
[Journal Article] Embryonic stem cell-derived neuron models of Parkinson's disease exhibit delayed neuronal death.2006
- Author(s)
  Yamashita H. et al.
- Journal Title
  
  J Neurochem (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390252
[Journal Article] Embryonic stem cell-derived neuron models of Parkinson's disease exhibit delayed neuronal death2006
- Author(s)
  Yamashita H, et al.
- Journal Title
  
  J Neurochem (in press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390252
[Journal Article] パーキンソン病の病態解明2004
- Author(s)
  山下拓史
- Journal Title
  
  日本臨床 62
  
  Pages: 1594-1596
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590893
[Journal Article] Elucidation of the pathogenesis of Parkinson's disease2004
- Author(s)
  Yamashita H, et al.
- Journal Title
  
  Nippon Rinsho 62
  
  Pages: 1594-1596
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590893

1. MATSUMOTO Masayasu (20192346)

# of Collaborated Projects: 4 results

# of Collaborated Products: 2 results
2. KATAYAMA Sadao (00211160)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. KAWAKAMI Hideshi (70253060)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. TAKAHASHI Tetsuya (00435942)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
5. HATTORI Nobutaka (80218510)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. YUGE Rui (20263676)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. OHTSUKI Toshiho (20418792)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. TAHARA Hidetoshi (00271065)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. KITAGAWA Kazuo (70301257)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 中村重信 (30026843)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 丸山博文 (90304443)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

YAMASHITA Hiroshi 山下 拓史

山下 拓史 ヤマシタ ヒロシ

Research Projects

Research Products

Co-Researchers

Optimal therapeutic approach on ischemic brain insult using bone marrow stromal cells cultured under simulated microgravity

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis on aggregation formation by novel Lewy body component Siah-1 complementary to ParkinPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

OPTIMAL REGULATION OF NEUROGENESIS AND NEURAL STEM CELLS FOR THE TREATMENT OF ISCHEMIC CEREBROVASCULAR DISEASE

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

IDENTIFICATION AND CHARACTERIZATION OF A NOVEL UBIQUITIN LIGASE SIAH THAT EXHIBITS COMPLEMENTARY ROLES WITH PARKINPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

CLINICAL APPLICATIONS OF NEUROGENESIS FOR THE TREATMENT OF ISCHEMIC CEREBROVASCULAR DISEASE

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

α-synucleinキナーゼの同定とα-synuclein凝集機序の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

α-synucleinの凝集過程におけるα-synucleinキナーゼの役割Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

神経細胞死予防のためのグルタミン酸・ドーパミン輸送蛋白の研究

Principal Investigator

Project Period (FY)

Research Category

Research Institution

α-synucleinキナーゼの同定とα-syuclein凝集機序の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

神経細胞におけるG蛋白共役型受容体からPYK2を介したシグナル伝達経路の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] White matter lesions in the brain with frontotemporal lobar degeneration with motor neuron disease : TDP-43-immunopositive inclusions co-localize with p62, but not ubiquitin.2008

Author(s)

Journal Title

Data Source

[Journal Article] Synphilin-1 transgenic mice exhibit mild motor impairments.2008

Author(s)

Journal Title

Data Source

[Journal Article] Embryonic stem cell-derived neuron models of Parkinson's disease exhibit delayed neuronal death2006

Author(s)

Journal Title

Data Source

[Journal Article] Embryonic stem cell-derived neuron models of Parkinson's disease exhibit delayed neuronal death.2006

Author(s)

Journal Title

Description

YAMASHITA Hiroshi 山下拓史

山下拓史ヤマシタヒロシ