Kobayashi Masahisa 小林正久

… Alternative Names

KOBAYASHI Masahisa 小林正久

小林正久コバヤシマサヒサ

Less

Researcher Number	20312019
Other IDs
Affiliation (Current)	2025: 東京慈恵会医科大学, 医学部, 准教授
Affiliation (based on the past Project Information) *help	2009 – 2011: 東京慈恵会医科大学, 医学部, 講師 2007 – 2008: 東京慈恵会医科大学, 医学部, 助教 2003 – 2004: 東京慈恵会医科大学, 医学部, 助手
Review Section/Research Field	Except Principal Investigator Pediatrics
Keywords	Except Principal Investigator 免疫寛容 / 酵素補充療法 / ファブリー病 / 遺伝子治療 / 制御性T細胞 / 免疫応答 / ライソゾーム病 / アナフィラキシー / ポンペ病 / 抗CD3抗体 … More / 抗体 / ポンぺ病 / ライソゾーム蓄積症 / 酵素補充湯療法 / 神経症状 / ケミカルシャペロン / ゴーシェ病 / ムコ多糖症 / 脳血管関門 / HIV-Tat Less

Anti-CD3 antibody induced immune tolerance to infused enzyme in enzyme replacement therapy for lysosomal storage disease
- Principal Investigator
  
  ETO Yoshikatsu
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Jikei University School of Medicine
Immune tolerance induction in enzyme replacement therapy for lysosomal storage diseases
- Principal Investigator
  
  ETO Yoshikatsu
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Jikei University School of Medicine
ゴーシェ病の中枢神経症状発現機序及び治療に関する研究
- Principal Investigator
  
  井田博幸
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Jikei University School of Medicine
脳血管関門を通過する酵素製剤の開発に関する研究
- Principal Investigator
  
  大橋十也
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pediatrics
- Research Institution
  Jikei University School of Medicine

All 2011 2010 2009 2008 Other

All Journal Article Presentation

[Journal Article] Pathology of the First Autopsy Case Diagnosed as Mucolipidosis type III alpha/beta Suggesting Autophagic Dysfunction2011
- Author(s)
  Kobayashi H, Eto Y, et al
- Journal Title
  
  Mol Genet Metab
  
  Volume: 102 Pages: 170-175
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591333
[Journal Article] Minimum requirement of donor cells to reduce the glycolipid storage following bone marrow transplantation in a murine model of Fabry disease2011
- Author(s)
  Yokoi T, Kobayashi H, Shimada Y, Eto Y, Ishige N, Kitagawa T, Otsu M, Nakauchi H, Ida H, Ohashi T
- Journal Title
  
  J Gene Med
  
  Volume: 13 Issue: 5 Pages: 262-8
- DOI
  10.1002/jgm.1566
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591333, KAKENHI-PROJECT-23659533
[Journal Article] Oral administration of recombinant human acid alpha -glucosidase reduces specific antibody formation against enzyme in mouse2011
- Author(s)
  Ohashi T, Iizuka S, Shimada Y, Eto Y, Ida H, Hachimura S, Kobayashi H
- Journal Title
  
  Mol Genet Metab
  
  Volume: 103 Pages: 98-100
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591333
[Journal Article] Neonatal gene transfer using lentiviral vector for murine Pompe disease : long term expression and glycogen reduction.2010
- Author(s)
  Kyosen OS, Iizuka S, Kobayashi H, Kimura T, Fukuda T, Shen JS, Shimada Y, Ida H, Eto Y
- Journal Title
  
  Gene Therapy
  
  Volume: 17 Pages: 521-530
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591333
[Journal Article] Non-invasive high-risk screening for Fabry disease hemizygotesand heterozygotes.2008
- Author(s)
  Kitagawa T, Suzuki K, Ishige N, Ohashi T, Kobayashi M, Eto Y, Tanaka A, Odaka H, Owada M.
- Journal Title
  
  Pediatr Nephrol. 23
  
  Pages: 461-71
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591223
[Journal Article] Clinical manifestations and natural history of Japanese heterozygous females with Fabry disease.2008
- Author(s)
  Kobayashi M, Ohashi T, Sakuma M, Ida H, Eto Y.
- Journal Title
  
  J Inherit Metab Dis. Jan 21(Online Report)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591223
[Journal Article] Administration of anti-CD3 antibodies modulates the immune response to an infusion of alpha-glucosidase in mice
- Author(s)
  Toya Ohashi, Sayoko Iizuka, Yohta Shimada, Takashi Higuchi, Yoshikatsu Eto, Hiroyuki Ida, Hiroshi Kobayashi
- Volume
  (投稿中)
- Data Source
  KAKENHI-PROJECT-21591333
[Presentation] Anti-CD3 antibody reduces antibody formation and prevents lethal hypersensitivity reaction in enzyme replacement therapy for murinelysosomal storage diseases2011
- Author(s)
  Ohashi T, Iizuka S, Shimada Y, Eto Y, Ida H, Kobayashi H
- Organizer
  11th International Symposium on Lysosomal Storage Diseases
- Place of Presentation
  Madrid
- Data Source
  KAKENHI-PROJECT-21591333
[Presentation] Anti-CD3 antibody reduces antibody formation and prevents lethal hypersensitivity reaction in enzyme replacement therapy for Pompe disease in mouse2011
- Author(s)
  Ohashi T, Iizuka S, Shimada Y, Ida H, Eto Y, Kobayashi H
- Organizer
  Annual Symposium of the Society for the Study of Inborn Errors of Metabolism
- Place of Presentation
  Geneva, Switzerland
- Data Source
  KAKENHI-PROJECT-21591333
[Presentation] Anti-CD3 antibody reduces antibody formation and prevents lethal hypersensitivitv reaction in enzyme replacement therapy for murinelysosomal storage diseases2011
- Author(s)
  Ohashi T, Iizuka S, Shimada Y, Eto Y, Ida H, Kobayashi H
- Organizer
  11th International Symposium on Lysosomal Storage Diseases
- Place of Presentation
  Madrid, Spain(招待講演)
- Data Source
  KAKENHI-PROJECT-21591333
[Presentation] ライソゾーム病酵素補充療法における酵素製剤に対する免疫反応に関する研究2011
- Author(s)
  大橋十也、飯塚佐代子、嶋田洋太、樋口孝、井田博幸、衛藤義勝、小林博司
- Organizer
  第53回日本先天代謝異常学会
- Place of Presentation
  幕張
- Data Source
  KAKENHI-PROJECT-21591333
[Presentation] 日本人Fabry病家系の遺伝子変異についての研究遺伝子変異と臨床病型について2010
- Author(s)
  小林正久、大橋十也、井田博幸、衞藤義勝
- Organizer
  日本先天代謝異常学会総会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-21591333
[Presentation] MPSII型Knockoutマウスでの脳室内酵素治療に関する研究2010
- Author(s)
  樋口孝、清水寛美、河越しほ、福田隆浩、小林博司、井田博幸、大橋十也、平戸徹、西野勝哉、衞藤義勝
- Organizer
  日本先天代謝異常学会総会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-21591333
[Presentation] 抗CD3抗体によるポンペ病酵素補充療法での酵素製剤に対する免疫寛容導入2010
- Author(s)
  大橋十也, 飯塚佐代子, 衛藤義勝, 嶋田洋太, 井田博幸, 小林博司
- Organizer
  第52回日本先天代謝異常学会総会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-21591333
[Presentation] 濾紙血を用いたPompe病スクリーニング法の有用性と問題点2010
- Author(s)
  清水寛美、嶋田洋太、若林太一、小林博司、大橋十也、井田博幸、川井充、衞藤義勝
- Organizer
  日本先天代謝異常学会総会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-21591333
[Presentation] ポンペ病細胞におけるオートファジー活性化の分子機序2010
- Author(s)
  嶋田洋太、西山由梨佳、小林博司、衞藤義勝、井田博幸、大橋十也
- Organizer
  日本先天代謝異常学会総会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-21591333
[Presentation] 新生児MPS VIIマウスへの遺伝子治療におけるレンチウイルスベクタの長期発現2010
- Author(s)
  有賀賢典、小林博司、飯塚佐代子、金城栄子、清水寛美、衞藤義勝、大橋十也、井田博幸
- Organizer
  日本先天代謝異常学会総会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-21591333
[Presentation] ファブリ病モデルマウスに対する骨髄移植におけるキメリズムの決定2010
- Author(s)
  横井貴之、小林博司、衞藤義勝、石毛信之、北川照男、大津真、中内啓光、大橋十也、井田博幸
- Organizer
  日本先天代謝異常学会総会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-21591333
[Presentation] Immune tolerance induction in enzyme replacement therapy for Pompe disease by anti-CD3 antibody and oral enzyme administration2009
- Author(s)
  Ohashi T, Iizuka S, Kobayashi H, Shimada Y, Eto Y, Ida Y
- Organizer
  The 3th Internationl Symposium of Lysosomal Storage Diseases
- Place of Presentation
  Nagoya
- Data Source
  KAKENHI-PROJECT-21591333
[Presentation] Pompe病の酵素補充療法における酵素製剤に対する免疫寛容導入2009
- Author(s)
  大橋十也、飯塚佐代子、嶋田洋太, 小林博司, 衞藤義勝, 井田博幸
- Organizer
  第51回日本先天代謝異常学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-21591333
[Presentation] Immune tolerance induction in enzyme replacement therapy for Pompe disease by anti-CD3 antibody and oral enzyme administration.2009
- Author(s)
  Ohashi T, lizuka S, Kobayashi H, Shimada Y, Eto Y, Ida H.
- Organizer
  The 3^<th> Internationl Symposium of Lysosomal Storage Diseases.
- Place of Presentation
  Nagoya
- Data Source
  KAKENHI-PROJECT-21591333

1. ETO Yoshikatsu (50056909)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. KOBAYASHI Hiroshi (90266619)

# of Collaborated Projects: 2 results

# of Collaborated Products: 21 results
3. 大橋十也 (60160595)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. 井田博幸 (90167255)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. TAJIMA Asako (00328337)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 津田隆 (50188554)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 衛藤義勝

# of Collaborated Projects: 0 results

# of Collaborated Products: 21 results

Kobayashi Masahisa 小林 正久

KOBAYASHI Masahisa 小林 正久

小林 正久 コバヤシ マサヒサ

Research Projects

Research Products

Co-Researchers

Anti-CD3 antibody induced immune tolerance to infused enzyme in enzyme replacement therapy for lysosomal storage disease

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Immune tolerance induction in enzyme replacement therapy for lysosomal storage diseases

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ゴーシェ病の中枢神経症状発現機序及び治療に関する研究

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

脳血管関門を通過する酵素製剤の開発に関する研究

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Pathology of the First Autopsy Case Diagnosed as Mucolipidosis type III alpha/beta Suggesting Autophagic Dysfunction2011

Author(s)

Journal Title

Data Source

[Journal Article] Minimum requirement of donor cells to reduce the glycolipid storage following bone marrow transplantation in a murine model of Fabry disease2011

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Oral administration of recombinant human acid alpha -glucosidase reduces specific antibody formation against enzyme in mouse2011

Author(s)

Journal Title

Data Source

[Journal Article] Neonatal gene transfer using lentiviral vector for murine Pompe disease : long term expression and glycogen reduction.2010

Author(s)

Journal Title

Data Source

[Journal Article] Non-invasive high-risk screening for Fabry disease hemizygotesand heterozygotes.2008

Author(s)

Journal Title

Data Source

[Journal Article] Clinical manifestations and natural history of Japanese heterozygous females with Fabry disease.2008

Author(s)

Journal Title

Data Source

[Journal Article] Administration of anti-CD3 antibodies modulates the immune response to an infusion of alpha-glucosidase in mice

Author(s)

Volume

Data Source

[Presentation] Anti-CD3 antibody reduces antibody formation and prevents lethal hypersensitivity reaction in enzyme replacement therapy for murinelysosomal storage diseases2011

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] Anti-CD3 antibody reduces antibody formation and prevents lethal hypersensitivity reaction in enzyme replacement therapy for Pompe disease in mouse2011

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] Anti-CD3 antibody reduces antibody formation and prevents lethal hypersensitivitv reaction in enzyme replacement therapy for murinelysosomal storage diseases2011

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] ライソゾーム病酵素補充療法における酵素製剤に対する免疫反応に関する研究2011

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] 日本人Fabry病家系の遺伝子変異についての研究 遺伝子変異と臨床病型について2010

Kobayashi Masahisa 小林正久

KOBAYASHI Masahisa 小林正久

小林正久コバヤシマサヒサ

[Presentation] 日本人Fabry病家系の遺伝子変異についての研究遺伝子変異と臨床病型について2010