MATSUO Akinori 松尾明典

Researcher Number	20324585
Other IDs
Affiliation (based on the past Project Information) *help	2010 – 2014: 滋賀医科大学, 分子神経科学研究センター, 助教 2013: 滋賀医科大学, 学内共同利用施設等, 助教 2013: 藤田保健衛生大学, 医学部, 臨床准教授 2011: 滋賀医科大学, 分子神経科学研究センター, 講師 2002 – 2006: Shiga University of Medical Science, Molecular Neurosicence Centere, Researxh Associate, 分子神経科学研究センター, 助手 2003: Molecular Neuroscience Research Center, Assistant Professor, 分子神経学研究センター, 助手 2001: 滋賀医科大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Neurochemistry/Neuropharmacology / Nerve anatomy/Neuropathology Except Principal Investigator Anesthesiology/Resuscitation studies / Nerve anatomy/Neuropathology / Nerve anatomy/Neuropathology / Neurology / Neurochemistry/Neuropharmacology / Laboratory animal science / Nerve anatomy/Neuropathology
Keywords	Principal Investigator PC12 / translocation / GFP / cChAT / pChAT / HEK293 / リン酸化 / トランスロケーション / bChAT / HEK-293 … More / NELL2 / DNAアレー / コリントランスポーター / アセチルコリン合成酵素 … More Except Principal Investigator pChAT / alternative splicing / アルツハイマー病 / アセチルコリン / immunohistochemistry / dorsal root ganglion / nociception / cholinergic neuron / PCR / FRET / memory / learning / acetylcholine / mRNA / 記憶 / 学習 / アミロイドβ / コリン作動性神経 / antibody / cholinergic neurons / alternative splicin / 抗体 / histochemistry / splice variant / choline acetyltransferase / 定量PCR / スプライシング異型 / 蛍光共鳴エネルギー転移 / 組織化学法 / スプライス異型 / コリンアセチル基転位酵素 / choinesterase inhibitor / neurotransmitter / Alzheimer's disease / コリンエステラーゼ阻害薬 / コリンエストラーゼ阻害薬 / 神経伝達物質 / 認知症 / トランスジェニック・マウス / βアミロイド / 神経疾患 / γセクレターゼ / FAM3C / ILEI / アミロイドβ蛋白 / 疾患モデル / 霊長類 / AAVベクター / カニクイザル / アデノ随伴ウイルス / 神経トレース / カベオリン / 海馬 / 内側中隔 / 神経回路網 Less

アセチルコリン合成酵素の細胞核内機能の解明Principal Investigator
- Principal Investigator
  
  松尾明典
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Fujita Health University
  Shiga University of Medical Science
Model animals by nonhuman primate for Alzheimer disease, hyper expression of mutant amyloid precursor protein and formation of senile plaques in the brain
- Principal Investigator
  
  NAKAMURA Shinichiro
- Project Period (FY)
  2011 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Laboratory animal science
- Research Institution
  Shiga University of Medical Science
Development of therapeutic strategy for Alzheimer's disease by targeting amyloid precursor protein C99
- Principal Investigator
  
  NISHIMURA Masaki
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Shiga University of Medical Science
Analysesonthe projection pattern of theseptohippocampal cholinergic pathwayand its degeneratingprocess.
- Principal Investigator
  
  YASUHARA Osamu
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  The University of Shiga Prefecture
Novel cholineacetyltransferase variants (pChAT) in the brain of human and monkey
- Principal Investigator
  
  TOOYAMA Ikuo
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Shiga University of Medical Science
Involvement of cholinergic dorsal root ganglionic neurons in nociception.
- Principal Investigator
  
  AIMI Yoshinari
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  Shiga University of Medical Science
Analysis of intracellular translocation of choline acetyltransferase by bioimagingPrincipal Investigator
- Principal Investigator
  
  MATSUO Akinori
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Shiga University of Medical Science
Analysis of tissue specific expression of ChAT mRNA splice variants by in situ FRET method.
- Principal Investigator
  
  AIMI Yoshinari
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Shiga University of Medical Sciences
Study on novel cholinergic pathways in the brain of patients with Alzheimer's disease
- Principal Investigator
  
  TOOYAMA Ikuo
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Shiga University of Medical Science

All 2012 2011 2007 2005 2004 2003

All Journal Article Presentation

[Journal Article] Human neural stem cells over-expressing choline acetyltransferase restore cognition in rat model of cognitive dysfunction.2012
- Author(s)
  Park, D., Lee, H.J., Joo,S.S.,Bae, D-K., Yang. G., Yang, Y-H., Lim, I., Matsuo, A., Tooyama, I., Kim, Y-B., Kim, S.U.
- Journal Title
  
  Exp. Neurol.
  
  Volume: 234 Pages: 521-526
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22500308
[Journal Article] Human neural stem cells overexpressing choline acetyltransferase restore cognition in rat model of cognitive dysfunction2012
- Author(s)
  Park D, Lee HJ, Joo SS, Lim I, Matsuo A, Tooyama I, Kim YB, Kim SU
- Journal Title
  
  Experimental Neurology
  
  Volume: 234(2) Issue: 2 Pages: 521-526
- DOI
  10.1016/j.expneurol.2011.12.040
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23300155
[Journal Article] Human Neural Stem Cells Overexpressing Choline Acetyltransferase Restore Cognitive Function of Kainic Acid-Induced Learning and Memory Deficit Animals2012
- Author(s)
  Park D, Joo SS, Kim TK, Lee SH, Kang H, Lee HJ, Lim I, Matsuo A, Tooyama I, Kim YB, Kim SU
- Journal Title
  
  Cell Transplantaion
  
  Volume: 36(5) Issue: 1 Pages: 365-371
- DOI
  10.3727/096368911x586765
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23300155
[Journal Article] Human neural stem cells overexpressing choline acetyltransferase restore cognitive function of kainic acid-induced learning and momorydeficit animals2012
- Author(s)
  Park, D., Joo, S.S., Kim,T.K.,Lee, S.H., Kang, H., Lee, H.J., Lim,I., Matsuo, A., Tooyama, I., Kim, Y-B., Kim, S.U.
- Journal Title
  
  Cell Transplantation 21
  
  Pages: 365-371
- URL
  http://dx.doi.org/10.3272/096368911X586765
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22500308
[Journal Article] Nuclear choline acetyltransferase activates transcription of a high-affinity choline transporter2011
- Author(s)
  Matsuo, A., Bellier, J-P.,Nishimura, M., Yasuhara, O., Saito, N., Kimura, H.
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 286 Pages: 5836-5845
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22500308
[Journal Article] Nuclear choline acetyltransferase activates transcription of a high-affinity choline transporter2011
- Author(s)
  Matsuo A, Bellier JP, Nishimura M, Yasuhara O, Saito N, Kimura H
- Journal Title
  
  J Biol Chem
  
  Volume: 286(7) Pages: 5836-5845
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23500445
[Journal Article] Nuclear choline acetyltransferase activiates transcription of a high-affinity choline transporter2011
- Author(s)
  Matsuo A, Bellier JP, Yasuhara O, et al.
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 286 Pages: 5836-5845
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22500308
[Journal Article] The production of antibodies that distinguish rat choline acetyltransferase from its splice variant product of a peripheral type.2007
- Author(s)
  Kimura S, Bellier J-P, Matsuo A, Tooyama I, Kimura H
- Journal Title
  
  Neurochemical International 581
  
  Pages: 251-255
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16300111
[Journal Article] The production of antibodies that distinguish rat choline acetyltransferase from its splice variant product of a peripheral type.2007
- Author(s)
  Kimura S, Bellier J-P, Matsuo A, Tooyama I, Kimura H
- Journal Title
  
  Neurochem Internatinal 50
  
  Pages: 251-255
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16300111
[Journal Article] Rat choline acetyltransferase of the peripheral type differs from that of the common type in intracellular translocation.2005
- Author(s)
  Matsuo_A, Bellier JP, Hisano T, Aimi Y, Yasuhara O, Tooyama I, Saito N, Kimura H.
- Journal Title
  
  Neurochemistry International 46・5
  
  Pages: 423-433
- Data Source
  KAKENHI-PROJECT-16591533
[Journal Article] Rat choline acetyltransferase of the peripheral type differs from that of the common type in intracellular translocation.2005
- Author(s)
  Matsuo A., Belliera JP., Hisano T., Aimi Y., Yasuhara O., Tooyama I., Saito N., Kimura H.
- Journal Title
  
  Neurochem Int. 46
  
  Pages: 423-433
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15500257
[Journal Article] aFGF and pChAT in the rat enteric nervous system.2005
- Author(s)
  K.Nakajima, Y.Aimi, S.Kimura, J.P.Bellier, A.Matsuo, O.Yasuhara, I.Tooyama, H.Kimura.
- Journal Title
  
  Gastrointestinal motility 7
  
  Pages: 38-39
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16591533
[Journal Article] Rat choline acetyltransferase of the peripheral type differs from that of the common type in untracellular translocation.2005
- Author(s)
  A Matsuo, JP Bellier, T Hisano, Y Aimi, O Yasuhara, I Tooyama, N Saito, H Kimura
- Journal Title
  
  Neurochemical International 46
  
  Pages: 423-433
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16300111
[Journal Article] Rat choline acetyltransferase of the peripheral type differs from that of the common type in intracellular translocation.2005
- Author(s)
  Matsuo A., Belliera JP., Hisano T., Aimi Y., Yasuhara O., Tooyama I., Saito N., Kimura H.
- Journal Title
  
  Neurochemistry International 46・5
  
  Pages: 423-433
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15500257
[Journal Article] ラット腸管神経系におけるaFGFとpChATの形態学的研究2005
- Author(s)
  中島恭二, 相見良成, 木村新, ジャンーピエール・ペリエ, 松尾明典, 安原治, 遠山育夫, 木村宏
- Journal Title
  
  消化管運動-目にみえない消化器疾患を追う 7
  
  Pages: 37-39
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16591533
[Journal Article] Rat choline acetyltransferase of the peripheral type differs from that of the common type in untracellular translocation.2005
- Author(s)
  A Matsuo, JP Bellier, T Hisano, Y Aimi, O Yasuhara, I Tooyama, N Saito, H Kimura
- Journal Title
  
  Neurochem International 46
  
  Pages: 423-433
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16300111
[Journal Article] Rat choline acetyltransferase of the peripheral type differs from that of the common type in intracellular translocation.2005
- Author(s)
  A.Matsuo, J.P.Bellier, T.Hisano, Y.Aimi, 0.Yasuhara, I.Tooyama, N.Saito, H.Kimura
- Journal Title
  
  Nuerochem Int 46
  
  Pages: 423-433
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16591533
[Journal Article] Rat cholineacetyltransferase of the peripheral type differs from that of the common type in intracellular translocation.2005
- Author(s)
  A Matsuo, JP Belier, T Hisano, Y Aimi, O Yasuhara, I Tooyama, N Saito, H Kimura
- Journal Title
  
  Neurochemistry International 46・5
  
  Pages: 423-433
- Data Source
  KAKENHI-PROJECT-16300111
[Journal Article] Rat choline acetyltransferase of the peripheral type differs from that of the common type in intracellular translocation.2005
- Author(s)
  A.Matsuo, J.P.Bellier, T.Hisano, Y.Aimi, O.Yasuhara, I.Tooyama, N.Saito, H.Kimura
- Journal Title
  
  Neurochem Int 46
  
  Pages: 423-433
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16591533
[Journal Article] Innervation of rat iris by trigeminal and ciliary neurons expressing pChAT, a novel splice variant of choline acetyltransferase.2004
- Author(s)
  Yasuhara O., Aimi Y., Shibano A., Matsuo_A., Bellier JP., Park M., Tooyama I., Kimura H.
- Journal Title
  
  Journal of Comparative Neurology 472・2
  
  Pages: 232-245
- Data Source
  KAKENHI-PROJECT-15500257
[Journal Article] Innervation of rat iris by trigeminal and ciliary neurons expressing pChAT, a novel splice variant of choline acetyltransferase.2004
- Author(s)
  Yasuhara O., Aimi Y., Shibano A., Matsuo A., Bellier JP., Park M., Tooyama I., Kimura H.
- Journal Title
  
  J Comp Neurol. 472
  
  Pages: 232-245
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15500257
[Journal Article] Genetic risk factors for Alzheimer's disease2004
- Author(s)
  Tooyama I, Matsuo A, Yasuhara O.
- Journal Title
  
  Nippon Rinsho 62 Suppl
  
  Pages: 46-51
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15500257
[Journal Article] Different mechanisms of corpus callosum atrophy in Alzheimer's disease and vascular dementia.2004
- Author(s)
  Tomimoto H., Lin J-Xi., Matsuo A., Ihara M., Ohtani R., Shibata M., Miki Y., Shibasaki H.
- Journal Title
  
  J Neurol. 251
  
  Pages: 398-406
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15500257
[Journal Article] Topographical and cytopathological lesion analysis of the white matter in Binswanger's disease brains.2004
- Author(s)
  Akiguchi I., Tomimoto H., Wakita H., Kawamoto Y., Matsuo A., Ohnishi K., Watanabe T., Budka H.
- Journal Title
  
  Acta Neuropathologica (Berl). 107
  
  Pages: 563-570
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15500257
[Journal Article] Innervation of rat iris by trigeminal and ciliary neurons expressing pChAT, a novel splice variant of choline acetyltranferase.2004
- Author(s)
  O Yasuhara, Y Aimi, A Shibano, A Matsuo, JP Bellier, M Park, I Tooyama, H Kimura
- Journal Title
  
  Journal Comparative Neurology 472
  
  Pages: 232-245
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16300111
[Journal Article] Topographical and cytopathological lesion analysis of the white matter in Binswanger's disease brains.2004
- Author(s)
  Akiguchi I., Tomimoto H., Wakita H., Kawamoto Y., Matsuo A, Ohnishi K., Watanabe T., Budka H.
- Journal Title
  
  Acta Neuropathol (Berl) 107
  
  Pages: 563-570
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15500257
[Journal Article] Innervation of rat iris by trigeminal and ciliary neurons expressing pChAT, a novel splice variant of choline acetyltranferase.2004
- Author(s)
  O Yasuhara, Y Aimi, A Shibano, A Matsuo, JP Bellier, M Park, I Tooyama, H Kimura
- Journal Title
  
  J Comp Neurol 472
  
  Pages: 232-245
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16300111
[Journal Article] Different mechanisms of corpus callosum atrophy in Alzheimer's disease and vascular dementia.2004
- Author(s)
  Tomimoto H., Lin J-Xi., Matsuo A., Ihara M., Ohtani R., Shibata M., Miki Y, Shibasaki H.
- Journal Title
  
  Journal of Neurology 251
  
  Pages: 398-406
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15500257
[Journal Article] Innervation of rat iris by trigeminal and ciliary neurons expressing pChAT, a novel splice variant of choline acetyltransferase.2004
- Author(s)
  Yasuhara O., Aimi Y., Shibano A., Matsuo A., Bellier JP., Park M., Tooyama I., Kimura H.
- Journal Title
  
  Jounal of Comparative Neurology 472・2
  
  Pages: 232-245
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15500257
[Journal Article] Demonstration of cholinergic ganglion cells in rat retina: expression of an alternative splice variant of choline acetyltransferase.2003
- Author(s)
  Yasuhara O., Tooyama I., Aimi Y., Bellier JP., Hisano T., Matsuo A., Park M., Kimura H.
- Journal Title
  
  J Neurosci. 23
  
  Pages: 2872-2881
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15500257
[Journal Article] Expression of a splice variant of choline acetyltransferase in magnocellular neurons of the tuberomammillary nucleus of rat.2003
- Author(s)
  Kanayama H., Yasuhara O., Matsuo A., Tooyama I., Aimi Y., Bellier J.-P., Nagy J., I., Fukui K., Kimura H.
- Journal Title
  
  Neuroscience 118
  
  Pages: 243-251
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15500257
[Journal Article] Expression of a splice variant of choline acetyltransferase in magnocellular neurons of the tuberomammillary nucleus of rat.2003
- Author(s)
  Kanayama H., Yasuhara O., Matsuo A., Tooyama I., Aimi Y, Bellier J.-P., Nagy J., I., Fukui K., Kimura H.
- Journal Title
  
  Neuroscience 118
  
  Pages: 243-251
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15500257
[Journal Article] Demonstration of Fibroblast Growth Factor Receptor-1 in Rat Adrenal Gland as Revealed by Reverse Transcription-polymerase Chain Reaction and Immunohistochemistry.2003
- Author(s)
  Iwami M., Tooyama I, Kinoshita A., Matsuo A., Oomura Y., Sasaki K., Kimura H.
- Journal Title
  
  Acta Histochem.Cytochem. 36
  
  Pages: 353-359
- NAID
  110003144290
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15500257
[Journal Article] Demonstration of cholinergic ganglion cells in rat retina : expression of an alternative splice variant of choline acetyltransferase.2003
- Author(s)
  Yasuhara O., Tooyama I., Aimi Y, Bellier JP., Hisano T., Matsuo A., Park M., Kimura H.
- Journal Title
  
  Journal of Neuroscience 23
  
  Pages: 2872-2881
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15500257
[Presentation] Immunohistochemical localization of the GTP cyclohydrolase feedback regulatory protein (GFRP) in the rat brainstem.2012
- Author(s)
  Bellier JP, Yasuhara O, Ding WG, Matsuo A, Tooyama I
- Organizer
  14th International Congress of Histochemistry and Cytochemistry (ICHC 2012)
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-24500407
[Presentation] uclearcholine acetyltransferase activates transcription of a high-affinity choline transporter2011
- Author(s)
  Matsuo, A., Bellier, J-P.,Nishimura, M., Saito, N., Yasuhara, O., Kimura, H.
- Organizer
  8th IBROWorldCongressof Neuroscience
- Place of Presentation
  Florence, Italy
- Year and Date
  2011-07-14
- Data Source
  KAKENHI-PROJECT-22500308
[Presentation] Nuclear choline acetyltransferase activates transcription of a high-affinity choline transporter.2011
- Author(s)
  Matsuo A, et al.
- Organizer
  The 8th IBRO World Congress of Neuroscience
- Place of Presentation
  Florence
- Data Source
  KAKENHI-PROJECT-23500445
[Presentation] Nuclear choline acetyltransferase activates transcription of a high-affinity choline transporter2011
- Author(s)
  Matsuo A, Bellier JP, Nishimura M, Yasuhara O, Saito N, Kimura H
- Organizer
  The 8th IBRO World Congress of Neuroscience
- Place of Presentation
  Florence
- Data Source
  KAKENHI-PROJECT-23500445

1. AIMI Yoshinari (20231756)

# of Collaborated Projects: 3 results

# of Collaborated Products: 14 results
2. YASUHARA Osamu (80239772)

# of Collaborated Projects: 2 results

# of Collaborated Products: 8 results
3. NISHIMURA Masaki (40322739)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
4. TOOYAMA Ikuo (20207533)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
5. MATSUDA Wakoto (80444446)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. FRUTA Takahiro (60314184)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. NAKAMURA Shinichiro (50307980)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. OKADA Takashi (00326823)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. SAITO Naoaki (60178499)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
10. KIMURA Hiroshi (40079736)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
11. 岡田尚巳 (00326828)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

MATSUO Akinori 松尾 明典

Research Projects

Research Products

Co-Researchers

アセチルコリン合成酵素の細胞核内機能の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Model animals by nonhuman primate for Alzheimer disease, hyper expression of mutant amyloid precursor protein and formation of senile plaques in the brain

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of therapeutic strategy for Alzheimer's disease by targeting amyloid precursor protein C99

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysesonthe projection pattern of theseptohippocampal cholinergic pathwayand its degeneratingprocess.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Novel cholineacetyltransferase variants (pChAT) in the brain of human and monkey

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Involvement of cholinergic dorsal root ganglionic neurons in nociception.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of intracellular translocation of choline acetyltransferase by bioimagingPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of tissue specific expression of ChAT mRNA splice variants by in situ FRET method.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study on novel cholinergic pathways in the brain of patients with Alzheimer's disease

Principal Investigator

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[Journal Article] Human neural stem cells over-expressing choline acetyltransferase restore cognition in rat model of cognitive dysfunction.2012

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[Journal Article] Human neural stem cells overexpressing choline acetyltransferase restore cognition in rat model of cognitive dysfunction2012

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[Journal Article] Human Neural Stem Cells Overexpressing Choline Acetyltransferase Restore Cognitive Function of Kainic Acid-Induced Learning and Memory Deficit Animals2012

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[Journal Article] Human neural stem cells overexpressing choline acetyltransferase restore cognitive function of kainic acid-induced learning and momorydeficit animals2012

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[Journal Article] Nuclear choline acetyltransferase activates transcription of a high-affinity choline transporter2011

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MATSUO Akinori 松尾明典