KATO Takanobu 加藤孝宣

Researcher Number	20333370
Other IDs
External Links
Affiliation (Current)	2025: 国立健康危機管理研究機構, ウイルス第二部, 室長
Affiliation (based on the past Project Information) *help	2016 – 2025: 国立感染症研究所, ウイルス第二部, 室長 2015: 国立感染症研究所, その他部局等, 室長 2009 – 2014: National Institute of Infectious Diseases, ウイルス第二部, 室長 2002 – 2005: 名古屋市立大学, 大学院・医学研究科, 助手 2003: 名古屋市立大学, 医学部, 助手 … More 2003: 名古屋市立大学, 大学院・医学研究科・共同研究センター, 助手 2002 – 2003: 名古屋市立大学, 大学院・医学研究科・共同研究教育センター, 助手 2002: 名古屋市立大学, 医学部臨床分子情報医学, 助手 2001: (財)東京都医学研究機構, 東京都神経科学総合研究所, 研究員 Less
Review Section/Research Field	Principal Investigator Gastroenterology / Basic Section 53010:Gastroenterology-related / Gastroenterology Except Principal Investigator Gastroenterology / Basic Section 49060:Virology-related / Gastroenterology / Virology / Virology
Keywords	Principal Investigator HCV / B型肝炎 / 細胞培養 / HBV / 肝発癌 / インターフェロン / 薬剤感受性 / C型肝炎ウイルス / スクリーニング / ペプトイド … More / 抗菌ペプチド / コア蛋白質 / cccDNA / 遺伝子変異 / 臨床的治癒 / B型慢性肝炎 / プロモーター / B型肝炎ウイルス / HBcr抗原 / 細胞培養モデル / 粒子形成 / HBs抗原 / HCC / HBsAg / 慢性肝炎 / 薬剤耐性 / ウイルス培養実験 / ウイルス増殖モデル / 動物モデル / 慢性感染 / チンパンジー / 感染実験 / ウイルス培養 / 慢性化 / レプリコンシステム / リバビリン / ジエチルニトロサミン / 四塩化炭素 / 化学発癌 / トランスジェニックマウス … More Except Principal Investigator HCV / HCC / 慢性肝炎 / ウイルス / interferon / chronic hepatitis / viral genome replication / virus / インターフェロン / 肝臓癌 / ウイルスゲノム複製 / トランスジェニックマウス / 肝発癌 / ジェノタイプ / ウイルス複製 / 肝細胞がん / B型肝炎ウイルス / マウスモデル / ウイルス発癌 / 肝細胞癌 / 慢性感染 / 発癌 / chronic infection / Hepatitis B virus / 発ガン / 遺伝子型 / 動物モデル / B型肝炎 / リバビリン / レプリコン / Heoatocarcinogenesis / CCL4 / TRANSGENIC MOUSE / 慢性肝障害 / 四塩化炭素 / DNA免疫 / CTL / コア蛋白質 / デングウイルス特異的T細胞 / デングウイルス出血熱 / デングショック症候群 / デング出血熱 / デングウイルス / SAPプロモーター / アルプミンプロモーター / 肝炎モデル / 構造蛋白 / コア蛋白 Less

HBVプレゲノムRNA導入法を用いたHBVライフサイクル評価系の構築Principal Investigator
- Principal Investigator
  
  加藤孝宣
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  National Institute of Infectious Diseases
抗菌ペプトイドを用いた新規B型肝炎治療薬の開発Principal Investigator
- Principal Investigator
  
  加藤孝宣
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  National Institute of Infectious Diseases
Why genotype C HBV causes liver cancer more rapidly than other genotypes?
- Principal Investigator
  
  村松正道
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49060:Virology-related
- Research Institution
  Foundation for Biomedical Research and Innovation at Kobe
  National Institute of Infectious Diseases
Amino Acid Polymorphism in Hepatitis B Virus Associated With Functional CurePrincipal Investigator
- Principal Investigator
  
  Kato Takanobu
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  National Institute of Infectious Diseases
Evaluation of HBsAg-associated hepatocarcinogenesisPrincipal Investigator
- Principal Investigator
  
  KATO TAKANOBU
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  National Institute of Infectious Diseases
Amino Acid Polymorphism in HCHV Core Affects Infectious Virus Production and MHC Class I Molecule ExpressionPrincipal Investigator
- Principal Investigator
  
  KATO Takanobu
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  National Institute of Infectious Diseases
In Vitro Behavior of Hepatitis C Virus JFH-1 Strains with Mutations Emerged after Passage in ChimpanzeesPrincipal Investigator
- Principal Investigator
  
  KATO Takanobu
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  National Institute of Infectious Diseases
HCVレプリコンシステムを用いた薬剤感受性規定領域の検討Principal Investigator
- Principal Investigator
  
  加藤孝宣
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Nagoya City University
Viral genomic region of Hepatitis C Virus which determine viral replication and drug sensitivity
- Principal Investigator
  
  MIYAMOTO Michiko
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Virology
- Research Institution
  Tokyo Metropolitan Organization for Medical Research
Analysis of replication of Hepatitis C Virus using highly efficient replication system
- Principal Investigator
  
  WAKITA Takaji
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Tokyo Metropolitan Organization for Medical Research
デングウイルス感染マウスモデルを用いたデング出血熱の病態解析
- Principal Investigator
  
  YASUI Kotaro
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Virology
- Research Institution
  Tokyo Metropolitan Organization for Medical Research
慢性肝障害モデルマウスを用いたC型肝炎ウイルスによる肝発癌機構の解析Principal Investigator
- Principal Investigator
  
  加藤孝宣
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Nagoya City University
Construction and analysis of viral hepatocarcinogenesis model using HCV transgenic mouse model
- Principal Investigator
  
  WAKITA Takaji
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Tokyo Metropolitan Organization for Medical Research
C型肝炎ウイルストランスジェニックマウスを用いた肝炎及び肝癌発症機構の解析
- Principal Investigator
  
  古坂明弘
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Jikei University School of Medicine

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All Journal Article Presentation

[Journal Article] Antiviral effect of peptoids on hepatitis B virus infection in cell culture2024
- Author(s)
  Murayama Asako、Igarashi Hitomi、Yamada Norie、Aly Hussein Hassan、Molchanova Natalia、Lin Jennifer S.、Nishitsuji Hironori、Shimotohno Kunitada、Muramatsu Masamichi、Barron Annelise E.、Kato Takanobu
- Journal Title
  
  Antiviral Research
  
  Volume: 223 Pages: 105821-105821
- DOI
  10.1016/j.antiviral.2024.105821
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07998, KAKENHI-PROJECT-23K06575, KAKENHI-PROJECT-23K24142
[Journal Article] Amino Acid Polymorphism in Hepatitis B Virus Associated With Functional Cure2021
- Author(s)
  Honda T, Yamada N, Murayama A, Shiina M, Aly HH, Kato A, Ito T, Ishizu Y, Kuzuya T, Ishigami M, Murakami Y, Tanaka T, Moriishi K, Nishitsuji H, Shimotohno K, Ishikawa T, Fujishiro M, Muramatsu M, Wakita T, Kato T.
- Journal Title
  
  Cellular and Molecular Gastroenterology and Hepatology
  
  Volume: 12 Issue: 5 Pages: 1583-1598
- DOI
  10.1016/j.jcmgh.2021.07.013
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08482, KAKENHI-PROJECT-20K08382
[Journal Article] In vivo adaptation of hepatitis C virus in chimpanzees for efficient virus production and evasion of apoptosis2011
- Author(s)
  Saeed M, Shiina M, Date T, Akazawa D, Watanabe N, Murayama A, Suzuki T, Watanabe H, Hiraga N, Imamura M, Chayama K, Choi Y, Krawczynski K, Liang TJ, Wakita T, Kato T
- Journal Title
  
  Hepatology
  
  Volume: 54 Pages: 425-433
- Data Source
  KAKENHI-PROJECT-21590868
[Journal Article] Role of the Endoplasmic Reticulum-associated Degradation(ERAD) Pathway in Degradation of Hepatitis C Virus Envelope Proteins and Production of Virus Particles2011
- Author(s)
  Saeed M, Suzuki R, Watanabe N, Masaki T, Tomonaga M, Muhammad A, Kato T, Matsuura Y, Watanabe H, Wakita T, Suzuki T
- Journal Title
  
  J Biol Chem
  
  Volume: 286 Pages: 37264-37273
- Data Source
  KAKENHI-PROJECT-21590868
[Journal Article] Development of recombinant hepatitis C virus with NS5A from strains of genotypes 1 and 22011
- Author(s)
  Okamoto Y, Masaki T, Murayama A, Munakata T, Nomoto A, Nakamoto S, Yokosuka O, Watanabe H, Wakita T, Kato T
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 410 Pages: 404-409
- Data Source
  KAKENHI-PROJECT-21590868
[Journal Article] Studies on virus kinetics using infectious fluorescence-tagged hepatitis C virus cell culture2011
- Author(s)
  Yamamoto M, Sakamoto N, Nakamura T, Itsui Y, Nakagawa M, Nishimura-Sakurai Y, Kakinuma S, Azuma S, Tsuchiya K, Kato T, Wakita T, Watanabe M
- Journal Title
  
  Hepatol Res
  
  Volume: 41 Pages: 258-269
- Data Source
  KAKENHI-PROJECT-21590868
[Journal Article] Biological properties of purified recombinant HCV particles with an epitope-tagged envelope2010
- Author(s)
  Takahashi H, Akazawa D, Kato T, Date T, Shirakura M, Nakamura N, Mochizuki H, Tanaka-Kaneko K, Sata T, Tan aka Y, Mizokami M, Suzuki T, Wakita T
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 395 Pages: 565-571
- Data Source
  KAKENHI-PROJECT-21590868
[Journal Article] RNA polymerase activity and specific RNA structure are required for efficient HCV replication in cultured cells2010
- Author(s)
  Murayama A, Weng L, Date T, Akazawa D, Tian X, Suzuki T, Kato T, Tanaka Y, Mizokami M, Wakita T, Toyoda T
- Journal Title
  
  PLoS Pathog
  
  Volume: 6
- Data Source
  KAKENHI-PROJECT-21590868
[Journal Article] Characterization of Genotype 2a Hepatitis C Virus Subgenomic Replicon in Comparison with Genotype 1b Replicon.2006
- Author(s)
  M Miyamoto, T Kato, T Date, M Mizokami, T Wakita.
- Journal Title
  
  Intervirology 49
  
  Pages: 37-43
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590653
[Journal Article] Characterization of the replication sensitivity to cyclosporin A among strains of hepatitis C virus2006
- Author(s)
  N Ishii, K Watashi, T Hishiki, K Goto, D Inoue, M Hijikata, T Wakita, N Kato, K Shimotohno
- Journal Title
  
  Journal of Virology (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590396
[Journal Article] Characterization of the replication sensitivity to cyclosporin A among strains of hepatitis C virus2006
- Author(s)
  N Ishii, K Watashi, T Hishiki, K Goto, D Inoue, M Hijikata, T Wakita, N Kato, K Shimotohno
- Journal Title
  
  Journal of Virology (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590653
[Journal Article] Characterization of Genotype 2a Hepatitis C Virus Subgenomic Replicon in Comparison with Genotype 1b Replicon.2006
- Author(s)
  M Miyamoto, T Kato, T Date, M Mizokami, T Wakita.
- Journal Title
  
  Intervirology 49
  
  Pages: 37-43
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590396
[Journal Article] Non-Hepatic Cell Lines HeLa and 293 Cells Support Efficient Replication of Hepatitis C Virus Genotype 2a Subgenomic Replicon.2005
- Author(s)
  T Kato, et al.
- Journal Title
  
  Journal of Virology 79
  
  Pages: 592-596
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590396
[Journal Article] C型肝炎ウイルス培養細胞感染系の確立2005
- Author(s)
  加藤孝宣, 他
- Journal Title
  
  ウイルス 55(2)
  
  Pages: 287-296
- NAID
  10017102684
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590396
[Journal Article] Production of Infectious Hepatitis C Virus in Tissue Culture from a Cloned Viral Genome2005
- Author(s)
  T Wakita, T Pietschmann, T Kato, T Date, M Miyamoto, Z Zhao, K Murthy, A Habermann, H-G Krausslich, M Mizokami, R Bartenschlager, T J Liang
- Journal Title
  
  Nat Med. 11
  
  Pages: 791-796
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590653
[Journal Article] Robust Hepatitis C Virus Infection in Vitro2005
- Author(s)
  J Zhong, P Gastaminza, G Cheng, S Kapadia, T Kato, DR Burton, SF Wieland, S Uprichard, T Wakita, FV Chisari
- Journal Title
  
  PNAS 2005 102
  
  Pages: 9294-9299
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590396
[Journal Article] C型肝炎ウイルス培養細胞感染系の確立2005
- Author(s)
  加藤孝宣, 他
- Journal Title
  
  ウイルス 55(2)
  
  Pages: 287-296
- NAID
  10017102684
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590653
[Journal Article] Characterisation of the E-138 (Glu/Lys) mutation in Japanese encephalitis virus using a stable full-length infectious cDNA clone2005
- Author(s)
  Zhao Z, Date T, Li Y, Kato T, Miyamoto M, Yasui K, Wakita T.
- Journal Title
  
  J.Gen.Virol. 86
  
  Pages: 2209-2220
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590396
[Journal Article] Non-Hepatic Cell Lines HeLa and 293 Cells Support Efficient Replication of Hepatitis C Virus Genotype 2a Subgenomic Replicon.2005
- Author(s)
  T Kato, T Date, M Miyamoto, Z Zho, M Mizokami, T Wakita
- Journal Title
  
  Journal of Virology 79
  
  Pages: 592-596
- Data Source
  KAKENHI-PROJECT-16590653
[Journal Article] Detection of Anti-Hepatitis C Virus Effects of Interferon and Ribavirin by a Sensitive Replicon System2005
- Author(s)
  T Kato, T Date, M Miyamoto, M Sugiyama, Y Tanaka, E Orito, T Ohno, K Sugihara, I Hasegawa, K Fujiwara, K Ito, A Ozasa, M Mizokami, T Wakita.
- Journal Title
  
  Journal of Clinical Microbiology 43
  
  Pages: 5679-5684
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590653
[Journal Article] Detection of Anti-Hepatitis C Virus Effects of Interferon and Ribavirin by a Sensitive Replicon System2005
- Author(s)
  T Kato, T Date, M Miyamoto, M Sugiyama, Y Tanaka, E Orito, T Ohno, K Sugihara, I Hasegawa, K Fujiwara, K Ito, A Ozasa, M Mizokami, T Wakita.
- Journal Title
  
  Journal of Clinical Microbiology 43
  
  Pages: 5679-5684
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590396
[Journal Article] Robust Hepatitis C Virus Infection in Vitro2005
- Author(s)
  J Zhong, P Gastaminza, G Cheng, S Kapadia, T Kato, DR Burton, SF Wieland, S Uprichard, T Wakita, FV Chisari
- Journal Title
  
  PNAS 2005 102
  
  Pages: 9294-9299
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590653
[Journal Article] Characterisation of the E-138 (Glu/Lys) mutation in Japanese encephalitis virus using a stable full-length infectious cDNA clone2005
- Author(s)
  Zhao Z, Date T, Li Y, Kato T, Miyamoto M, Yasui K, Wakita T.
- Journal Title
  
  J.Gen.Virol. 86
  
  Pages: 2209-2220
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590653
[Journal Article] Non-Hepatic Cell Lines HeLa and 293 Cells Support Efficient Replication of Hepatitis C Virus Genotype 2a Subgenomic Replicon.2005
- Author(s)
  T Kato, et al.
- Journal Title
  
  Journal of Virology 79
  
  Pages: 592-596
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590653
[Journal Article] Detection of Anti-Hepatitis C Virus Effects of Interferon and Ribavirin by a Sensitive Replicon System2005
- Author(s)
  T Kato, et al.
- Journal Title
  
  Journal of Clinical Microbiology 43
  
  Pages: 5679-84
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590396
[Journal Article] Non-Hepatic Cell Lines HeLa and 293 Cells Support Efficient Replication of Hepatitis C Virus Genotype 2a Subgenomic Replicon.2005
- Author(s)
  T Kato, T Date, M Mivamoto, Z Zhao, M Mizokami, T Wakita
- Journal Title
  
  J Virol 79
  
  Pages: 592-596
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590396
[Journal Article] Detection of Anti-Hepatitis C Virus Effects of Interferon and Ribavirin by Sensitive Replicon System2005
- Author(s)
  T Kato, et al.
- Journal Title
  
  Journal of Clinical Microbiology 43
  
  Pages: 5679-84
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590653
[Journal Article] Non-Hepatic Cell Lines HeLa and 293 Cells Support Efficient Replication of Hepatitis C Virus Genotype 2a Subgenomic Replicon.2005
- Author(s)
  T Kato, T Date, M Mivamoto, Z Zhao, M Mizokami, T Wakita
- Journal Title
  
  J Virol 79
  
  Pages: 592-596
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590653
[Journal Article] Production of Infectious Hepatitis C Virus in Tissue Culture from a Cloned Viral Genome2005
- Author(s)
  T Wakita, T Pietschmann, T Kato, T Date, M Miyamoto, Z Zhao, K Murthy, A Habermann, H-G Krausslich, M Mizokami, R Bartenschlager, T J Liang
- Journal Title
  
  Nat Med. 11
  
  Pages: 791-796
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590396
[Journal Article] Non-Hepatic Cell Lines HeLa and 293 Cells Support Efficient Replication of Hepatitis C Virus Genotype 2a Subgenomic Replicon.2005
- Author(s)
  T Kato, T Date, M Miyamoto, Z Zho, M Mizokami, T Wakita
- Journal Title
  
  Journal of Virology 79
  
  Pages: 592-596
- Data Source
  KAKENHI-PROJECT-16590396
[Journal Article] Detection of Anti-Hepatitis C Virus Effects of Interferon and Ribavirin by a Sensitive Replicon System2005
- Author(s)
  T Kato, et al.
- Journal Title
  
  Journal of Clinical Microbiology 43
  
  Pages: 5679-5684
- Data Source
  KAKENHI-PROJECT-16590653
[Journal Article] Genotype 2a Hepatitis C Virus Subgenomic Replicon Can Replicate in HepG2 and IMY-N9 cells2004
- Author(s)
  Date T, Kato T, Miyamoto M, Zhao Z, Yasui K, Mizokami M, Wakita T
- Journal Title
  
  Journal of Biological Chemistry 279
  
  Pages: 22371-22376
- Data Source
  KAKENHI-PROJECT-16590396
[Journal Article] Difference of Hepatitis C Virus Core Protein Processing between Genotypes 1 and 2.2004
- Author(s)
  T Kato, et al.
- Journal Title
  
  Hapatology Research 30
  
  Pages: 204-209
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590653
[Journal Article] Regulation of Hepatitis C Virus Replication by Interferon Regulatory Facctor-12004
- Author(s)
  Kanazawa N, Kurosaki M, Sakamoto N, Enomoto N, Itsui Y, Yamashiro T, Tanabe Y, Maekawa S, Nakagawa M, Chen C-H, Oshima S, Nakamura T, Kato T, Wakita T, Watanabe M
- Journal Title
  
  J Virol 78
  
  Pages: 9713-9720
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590396
[Journal Article] Genotype 2a Hepatitis C Virus Subgenomic Replicon Can Replicate in HepG2 and IMY-N9 cells2004
- Author(s)
  Date T, Kato T, Miyamoto M, Zhao Z, Yasui K, Mizokami M, Wakita T
- Journal Title
  
  Journal of Biological Chemistry 279
  
  Pages: 22371-22376
- Data Source
  KAKENHI-PROJECT-16590653
[Journal Article] Difference of Hepatitis C Virus Core Protein Processing between Genotypes 1 and 2.2004
- Author(s)
  T Kato, et al.
- Journal Title
  
  Hepatology Research 30
  
  Pages: 204-209
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590396
[Journal Article] Genotype 2a Hepatitis C Virus Subgenomic Replicon Can Replicate in HepG2 and IMY-N9 cells2004
- Author(s)
  Date T, Kato T.Mivamoto M, Zhao Z, Yasui K, Mizokami M, Wakita T.
- Journal Title
  
  Journal of Biological Chemistry 279
  
  Pages: 22371-22376
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590653
[Journal Article] Difference of Hepatitis C Virus Core Protein Processing between Genotypes 1 and 2.2004
- Author(s)
  T Kato, M Miyamoto, T Date, A Furusaka, M Mizokami, T Wakita
- Journal Title
  
  Hepatology Research 30
  
  Pages: 204-209
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590396
[Journal Article] Genotype 2a Hepatitis C Virus Subgenomic Replicon Can Replicate in HepG2 and IMY-N9 cells2004
- Author(s)
  Date T, Kato T.Mivamoto M, Zhao Z, Yasui K, Mizokami M, Wakita T.
- Journal Title
  
  Journal of Biological Chemistry 279
  
  Pages: 22371-22376
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590396
[Journal Article] Regulation of Hepatitis C Virus Replication by Interferon Regulatory Facctor-12004
- Author(s)
  Kanazawa N, Kurosaki M, Sakamoto N, Enomoto N, Itsui Y, Yamashiro T, Tanabe Y, Maekawa S, Nakagawa M, Chen C-H, Oshima S, Nakamura T, Kato T, Wakita T, Watanabe M
- Journal Title
  
  J Virol 78
  
  Pages: 9713-9720
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590653
[Journal Article] Difference of Hepatitis C Virus Core Protein Processing between Genotypes 1 and 2.2004
- Author(s)
  T Kato, M Miyamoto, T Date, A Furusaka, M Mizokami, T Wakita
- Journal Title
  
  Hepatology Research 30
  
  Pages: 204-209
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590653
[Journal Article] In Vivo Adaptation of Hepatitis C Virus for Efficient Virus Production and Evasion of Apoptosis
- Author(s)
  Saeed M, Kato T, et al.
- Journal Title
  
  Hepatology
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590868
[Presentation] B型慢性肝炎患者における機能的治癒（Functional Cure）予測因子としてのコアI97L変異の可能性2022
- Author(s)
  本多隆, 加藤孝宣, 石上雅敏
- Organizer
  第108回消化器病学会総会
- Data Source
  KAKENHI-PROJECT-19K08482
[Presentation] B型慢性肝炎患者における機能的治癒(Functional Cure)症例の特徴とコアI97L変異の関係2022
- Author(s)
  本多隆, 加藤孝宣, 石上雅敏
- Organizer
  第58回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-19K08482
[Presentation] Functional cureに関与するコア領域のアミノ酸変異がHBVライフサイクルに与える影響の解析2021
- Author(s)
  加藤孝宣、山田典栄、本多　隆
- Organizer
  第57回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-19K08482
[Presentation] Amino Acid Polymorphism in Hepatitis B Virus Associated with Natural Clearance of HBV DNA and HBsAg.2020
- Author(s)
  2.Takashi Honda, Norie Yamada, Asako Murayama, Asuka Kato, Takanori Ito, Yoji Ishizu, Teiji Kuzuya, Masatoshi Ishigami, Yoshiki Murakami, Tetsuya Ishikawa, Mitsuhiro Fujishiro, Takanobu Kato.
- Organizer
  AASLD The Liver Meeting 2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08482
[Presentation] HCV core領域アミノ酸70/91変異株を用いた反応機序の解析2013
- Author(s)
  藤田めぐみ、加藤孝宣、村山麻子、山田典枝、脇田隆字、朝比奈靖浩、坂本直哉
- Organizer
  第４９回日本肝臓学会総会
- Place of Presentation
  京王プラザホテル
- Data Source
  KAKENHI-PROJECT-24591000
[Presentation] HCV Core領域アミノ酸70/91変異株を用いた反応機序の解析2013
- Author(s)
  藤田めぐみ，加藤孝宣，村山麻子，山田典栄，朝比奈靖浩，坂本直哉
- Organizer
  第49回日本肝臓学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24591000
[Presentation] Substitution of amino acid 70/91 in the hepatitis C core region affects infectious virus production and cell surface expression of MHC Class I.2013
- Author(s)
  Megumi Tasaka-Fujita, Nao-Sugiyama, Wonseok Kang, Asako Murayama, Naoya Sakamoto, Takaji Wakita, Eui-cheoul Shin, Takanobu Kato.
- Organizer
  The 64th Annual Meeting of the American Association for the Study of Liver Diseases
- Place of Presentation
  Washington DC
- Data Source
  KAKENHI-PROJECT-24591000
[Presentation] HCV genotype 1b株キメラウイルスを用いたHCV core領域アミノ酸70/91変異株の解析2012
- Author(s)
  藤田めぐみ、脇田隆字、加藤孝宣
- Organizer
  第４８回日本肝臓学会総会
- Place of Presentation
  ホテル日航金沢
- Data Source
  KAKENHI-PROJECT-24591000
[Presentation] HCV JFH-1株のチンパンジー感染実験で得られた適応変異株の機能解析2011
- Author(s)
  加藤孝宣、椎名正明、脇田隆字
- Organizer
  第15回日本肝臓学会大会
- Place of Presentation
  福岡
- Year and Date
  2011-10-20
- Data Source
  KAKENHI-PROJECT-21590868
[Presentation] C型肝炎ウイルスの生体内での感染様式と培養細胞での増殖能2010
- Author(s)
  加藤孝宣, 他
- Organizer
  第45回日本肝臓学会総会
- Place of Presentation
  山形
- Data Source
  KAKENHI-PROJECT-21590868
[Presentation] C型肝炎ウイルスJFH-1株患者血清のチンパンジーへの感染実験2010
- Author(s)
  加藤孝宣, Saeed Mohsan,脇田隆字
- Organizer
  第58回日本ウイルス学会学術集会
- Place of Presentation
  徳島
- Data Source
  KAKENHI-PROJECT-21590868
[Presentation] HCVの増殖適応変異とその意義2010
- Author(s)
  加藤孝宣,岡本有加,村山麻子,政木隆博,脇田隆字
- Organizer
  第58回日本ウイルス学会学術集会
- Place of Presentation
  徳島
- Data Source
  KAKENHI-PROJECT-21590868
[Presentation] Hepatitis C virus JFH-1 strain that adapted in vivo acquired abilities for efficient virus production and anti-apoptosis2010
- Author(s)
  Saeed M, Kato T, et al.
- Organizer
  The 16th International Symposium on HCV and Related Viruses
- Place of Presentation
  Yokohama, Japan
- Year and Date
  2010-09-11
- Data Source
  KAKENHI-PROJECT-21590868
[Presentation] C型肝炎ウイルスの生体内での感染様式と培養細胞での増殖能2009
- Author(s)
  加藤孝宣,伊達朋子,脇田隆字
- Organizer
  第45回日本肝臓学会総会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-21590868
[Presentation] Dynamic profile of gene expression in the liver during hepatitis C virus(HCV) JFH1 infection in chimpanzees2009
- Author(s)
  Youkyung Choi, Takanobu Kato, Takaji Wakita, Jake Liang, Krzyaztof Krawczynski
- Organizer
  16^<th> International Meeting on Hepatitis C Virus and Related Viruses
- Place of Presentation
  Nice, France
- Data Source
  KAKENHI-PROJECT-21590868
[Presentation] In vitro behavior of hepatitis C virus JFH-1 strains with mutations emerged after passage in chimpanzees2009
- Author(s)
  Mohsan Saeed, Takanobu Kato, Youkyung Choi, Krzyaztof Krawczynski, Jake Liang, Takaji Wakita
- Organizer
  16^<th> International Meeting on Hepatitis C Virus and Related Viruses
- Place of Presentation
  Nice, France
- Data Source
  KAKENHI-PROJECT-21590868
[Presentation] C型肝炎ウイルスの複製増殖に関与するウイルス遺伝子領域の検討2009
- Author(s)
  村山麻子,加藤孝宣,脇田隆字
- Organizer
  第45回日本肝臓学会総会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-21590868
[Presentation] Specific RNA structures and mutations implicated for HCV RNA replication and virus particle formation in cultured cells2009
- Author(s)
  Asako Murayama, Tomoko Date, Daisuke Akazawa, Takanobu Kato, Tetsuro Suzuki, and Takaji Wakita
- Organizer
  The Liver Meeting 2009, AASLD's 60th Annual Meeting
- Place of Presentation
  Boston, MA
- Data Source
  KAKENHI-PROJECT-21590868
[Presentation] C型肝炎ウイルスの複製増殖に関与するウイルス遺伝子変異および遺伝子構造の解析2009
- Author(s)
  村山麻子,伊達朋子,赤澤大輔,加藤孝宣,鈴木哲朗,豊田哲也,脇田隆字
- Organizer
  第57回日本ウイルス学会学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-21590868

1. WAKITA Takaji (40280789)

# of Collaborated Projects: 6 results

# of Collaborated Products: 24 results
2. MIYAMOTO Michiko (40190821)

# of Collaborated Projects: 5 results

# of Collaborated Products: 14 results
3. YASUI Kotaro (90073080)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. 古坂明弘 (00266678)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 溝上雅史 (40166038)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 村松正道 (20359813)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 五十川正記 (50723201)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 塩田智之 (80616144)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

KATO Takanobu 加藤 孝宣

Research Projects

Research Products

Co-Researchers

HBVプレゲノムRNA導入法を用いたHBVライフサイクル評価系の構築Principal Investigator

Principal Investigator

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Review Section

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抗菌ペプトイドを用いた新規B型肝炎治療薬の開発Principal Investigator

Principal Investigator

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Review Section

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Why genotype C HBV causes liver cancer more rapidly than other genotypes?

Principal Investigator

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Review Section

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Amino Acid Polymorphism in Hepatitis B Virus Associated With Functional CurePrincipal Investigator

Principal Investigator

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Review Section

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Evaluation of HBsAg-associated hepatocarcinogenesisPrincipal Investigator

Principal Investigator

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Amino Acid Polymorphism in HCHV Core Affects Infectious Virus Production and MHC Class I Molecule ExpressionPrincipal Investigator

Principal Investigator

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In Vitro Behavior of Hepatitis C Virus JFH-1 Strains with Mutations Emerged after Passage in ChimpanzeesPrincipal Investigator

Principal Investigator

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Research Institution

HCVレプリコンシステムを用いた薬剤感受性規定領域の検討Principal Investigator

Principal Investigator

Project Period (FY)

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Research Institution

Viral genomic region of Hepatitis C Virus which determine viral replication and drug sensitivity

Principal Investigator

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Research Institution

Analysis of replication of Hepatitis C Virus using highly efficient replication system

Principal Investigator

Project Period (FY)

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デングウイルス感染マウスモデルを用いたデング出血熱の病態解析

Principal Investigator

Project Period (FY)

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Research Institution

慢性肝障害モデルマウスを用いたC型肝炎ウイルスによる肝発癌機構の解析Principal Investigator

Principal Investigator

Project Period (FY)

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Research Institution

Construction and analysis of viral hepatocarcinogenesis model using HCV transgenic mouse model

Principal Investigator

Project Period (FY)

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KATO Takanobu 加藤孝宣