NOGUCHI Naoya 野口直哉

Researcher Number	20333792
External Links
Affiliation (Current)	2025: 東北医科薬科大学, 医学部, 講師
Affiliation (based on the past Project Information) *help	2016 – 2018: 東北大学, 医学系研究科, 非常勤講師 2015: 東北大学, 医学(系)研究科(研究院), 非常勤講師 2012: 仙台市立病院, 耳鼻咽喉科, 医長 2011: Tohoku University, 医学(系)研究科(研究院), その他 2010: 東北大学, 大学院・医学系研究科, 非常勤講師 … More 2007: Tohoku University, Graduate School of Medicine, Assistant Professor 2007: Tohoku University, 大学院・医学系研究科, 助教 2005 – 2006: 東北大学, 大学院医学系研究科, 助手 2002 – 2006: 東北大学, 大学院・医学系研究科, 助手 Less
Review Section/Research Field	Principal Investigator Otorhinolaryngology / Pathological medical chemistry / General medical chemistry / Pathological medical chemistry Except Principal Investigator General medical chemistry / Endocrinology
Keywords	Principal Investigator 細胞内カルシウム / サイクリックADPリボース / 遺伝子欠損マウス / FK506結合蛋白質 / 後迷路性難聴 / 蝸牛神経 / 神経科学 / Hidden hearing loss / 音響性聴覚障害 / マスキング … More / Hidden Hearing Loss / 難聴 / 免疫染色 / マウス内耳 / ヘパラン硫酸 / 制がん剤 / 細胞増殖抑制 / 遺伝子発現抑制 / 増殖因子 / がん / REG遺伝子 / シナプス長期抑圧現象 / 小脳プルキンエ細胞 / 自閉症 / 社会行動 / オキシトシン / CD38 / 耐糖能異常 / インスリン分泌 / 膵β細胞 … More Except Principal Investigator 糖尿病 / CICR / FKBP12.6 / CD38 / Reg receptor / the Reg gene family / pancreatic β-cell / knockout mouse / diabetes mellitus / reeenerative medicine / Reg受容体 / Regファミリー / 膵β細胞 / 遺伝子改変マウス / 移植・再生医療 / 再生医学 / Autism / Social recognition / Splicing / Cyclic ADP-ribose / Ryanodine receptor / FKBP / 発現制御 / 循環器・高血圧 / シグナル伝達 / 遺伝子 / 自閉症 / 社会認識異常 / スプライシング / サイクリックADPリボース / リアノジン受容体 / 新規圧療法 / ATF-2 / PPARγ / 新規降圧療法 / 治療抵抗性高血圧 / CYB11B2遺伝子 / アルドステロン / 分子高血圧学 / 内分泌学 Less

Cochlear synaptopathy in hearing loss due to retrolabyrinthine pathologyPrincipal Investigator
- Principal Investigator
  
  NOGUCHI Naoya
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Tohoku University
Innovation of a novel anti-hypertensive therapy due to the inhibitionof aldosterone synthase (CYP11B2) gene expression
- Principal Investigator
  
  SUGAWARA Akira
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Endocrinology
- Research Institution
  Tohoku University
内耳の形態形成・機能におけるヘパラン硫酸の役割の解明Principal Investigator
- Principal Investigator
  
  野口直哉
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Tohoku University
がん細胞のREG遺伝子の発現を抑制する制がん化合物の検索Principal Investigator
- Principal Investigator
  
  野口直哉
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Tohoku University
Targeted disruption of the Reg protein receptor gene : The relationship of the Reg-Reg receptor system with pancreatic 13-cell replication.
- Principal Investigator
  
  NATA Koji
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Iwate Medical University
  Tohoku University
Regulation of the CD38-cyclic ADP-ribose signal system by tissue-specific slicing of ryanodine receptor
- Principal Investigator
  
  TAKASAWA Shin
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Tohoku University
高次脳機能におけるサイクリックADPリボース情報伝達系の役割の解明Principal Investigator
- Principal Investigator
  
  野口直哉
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Tohoku University
遺伝子欠損マウスを用いたFK506結合蛋白資の生理機能の解明Principal Investigator
- Principal Investigator
  
  野口直哉
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Tohoku University

All 2012 2011 2010 2008

All Journal Article Presentation

[Journal Article] Identification of a major enzyme for the synthesis and hydrolysis of cyclic ADP-ribose in amphibian cells and evolutional conservation of the enzyme from human to invertebrate2012
- Author(s)
  Ikeda T, Takasawa S, Noguchi N, Nata K, Yamauchi A, Takahashi I, Yoshikawa T, Sugawara A, Yonekura H, Okamoto H.
- Journal Title
  
  Mol Cell Biochem
  
  Volume: 366 Issue: 1-2 Pages: 69-80
- DOI
  10.1007/s11010-012-1284-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591006, KAKENHI-PROJECT-22591096, KAKENHI-PROJECT-23590349, KAKENHI-PROJECT-23659161, KAKENHI-PROJECT-23792017
[Journal Article] All-trans retinoic acid and a novel synthetic retinoid tamibarotene (Am80) differentially regulate CD38 expression in human leukemia HL-60 cells : possible involvement of protein kinase C-{delta}2011
- Author(s)
  Uruno A, Noguchi N, Matsuda K, Nata K, Yoshikawa T, Chikamatsu Y, Kagechika H, Harigae H, Ito S, Okamoto H, Sugawara A.
- Journal Title
  
  J Leukoc Biol
  
  Volume: Epub ahead of print
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591006
[Journal Article] All-trans retinoic acid and a novel synthetic retinoid tamibarotene (Am80) differentially regulate CD38 expression in human leukemia HL-60 cells: possible involvement of protein kinase C-{delta}2011
- Author(s)
  Uruno A, Noguchi N, Matsuda K, Nata K, Yoshikawa T, Chikamatsu Y, Kagechika H, Harigae H, Ito S, Okamoto H, Sugawara A.
- Journal Title
  
  J Leukoc Biol
  
  Volume: 90 Issue: 2 Pages: 235-247
- DOI
  10.1189/jlb.0109025
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591006, KAKENHI-PROJECT-22890014
[Journal Article] Peroxisome proliferator-activated receptor-{gamma} suppresses CYP11B2 expression and aldosterone production2011
- Author(s)
  Uruno A, 他
- Journal Title
  
  J Mol Endcrino
  
  Volume: 46 Issue: 1 Pages: 37-49
- DOI
  10.1677/jme-10-0088
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390259, KAKENHI-PROJECT-22591006
[Journal Article] Up-regulation of REG Iα accelerates tumor progression in pancreatic cancer with diabetes2010
- Author(s)
  Zhou L, Zhang R, Wang L, Shen S, Okamoto H, Sugawara A, Xia L, Wang X, Noguchi N, Yoshikawa T, Uruno A, Yao W, Yuan Y
- Journal Title
  
  Int J Cancer
  
  Volume: 127 Pages: 1795-1803
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591006
[Journal Article] チアゾリジン誘導体はPPARγおよびCa^<2+>/カルモジュリン依存性キナーゼ(CaMK)を介して副腎皮質癌R295R細胞におけるアルドステロン分泌を抑制する2010
- Author(s)
  宇留野晃、松田謙、野口直哉、吉川雄朗、工藤正孝、佐藤文俊、伊藤貞嘉、岡本宏、菅原明
- Journal Title
  
  ACTH related peptides
  
  Volume: 20 Pages: 36-37
- Data Source
  KAKENHI-PROJECT-22591006
[Journal Article] FKBP12.6 disruption impairs glucose-induced insulin secretion2008
- Author(s)
  Noguchi, N
- Journal Title
  
  Biochemical and Biophysical Research Communications (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590255
[Journal Article] FKBP12.6 disruption impairs glucose-induced insulin secretion2008
- Author(s)
  Noguchi N.
- Journal Title
  
  Biochemical and Biophysical Research Comunication (in press)
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590255
[Presentation] Histamine receptor H3 regulates the functions of pancreatic β-cells2011
- Author(s)
  Nakamura T, Yoshikawa T, Noguchi N, Okamoto H, Sugawara A, Yanai K
- Organizer
  American Diabetes Association 71th Scientific Sessions
- Place of Presentation
  San Diego
- Data Source
  KAKENHI-PROJECT-22591006
[Presentation] Role of heparan sulfate in glucose-induced insulin secretion in MIN6 cells.2010
- Author(s)
  Yoshikawa T, Takayanagi S, Noguchi N, Uruno A, Okamoto H, Sugawara A, Yanai K.
- Organizer
  American Diabetes Association 70th Scientific Sessions
- Place of Presentation
  Orlando, USA
- Year and Date
  2010-06-26
- Data Source
  KAKENHI-PROJECT-22591006
[Presentation] Structural characterization of heparan sulfate in the Ext13 knockout mice and the pancreatic β-cell specific Ext13 knockout mice.2010
- Author(s)
  Kaneiwa T, Yamada S, Sugahara K, Takahashi I, Noguchi N, Nata K, Okamoto H, Sugawara A.
- Organizer
  25th International Carbohydrate Symposium
- Place of Presentation
  Tokyo
- Year and Date
  2010-08-02
- Data Source
  KAKENHI-PROJECT-22591006
[Presentation] Role of heparan sulfate in glucose-induced insulin secretion in mouse pancreatic β-cell line MIN6 cells.2010
- Author(s)
  Yoshikawa T, Takayanagi S, Noguchi N, Zhang D, Ariyama Y, Uruno A, Okamoto H, Sugawara A, Yanai K.
- Organizer
  16th World Congress of Basic and Clinical Pharmacology
- Place of Presentation
  Copenhagen, Denmark
- Year and Date
  2010-07-10
- Data Source
  KAKENHI-PROJECT-22591006

1. TAKASAWA Shin (50187944)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. NATA Koji (90202233)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. SUGAWARA Akira (90270834)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
4. KUDO Masataka (20509583)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. 岡本宏 (60025632)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 香取幸夫 (20261620)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 川瀬哲明 (50169728)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

NOGUCHI Naoya 野口 直哉

Research Projects

Research Products

Co-Researchers

Cochlear synaptopathy in hearing loss due to retrolabyrinthine pathologyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Innovation of a novel anti-hypertensive therapy due to the inhibitionof aldosterone synthase (CYP11B2) gene expression

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

内耳の形態形成・機能におけるヘパラン硫酸の役割の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

がん細胞のREG遺伝子の発現を抑制する制がん化合物の検索Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Targeted disruption of the Reg protein receptor gene : The relationship of the Reg-Reg receptor system with pancreatic 13-cell replication.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Regulation of the CD38-cyclic ADP-ribose signal system by tissue-specific slicing of ryanodine receptor

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

高次脳機能におけるサイクリックADPリボース情報伝達系の役割の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

遺伝子欠損マウスを用いたFK506結合蛋白資の生理機能の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Identification of a major enzyme for the synthesis and hydrolysis of cyclic ADP-ribose in amphibian cells and evolutional conservation of the enzyme from human to invertebrate2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] All-trans retinoic acid and a novel synthetic retinoid tamibarotene (Am80) differentially regulate CD38 expression in human leukemia HL-60 cells : possible involvement of protein kinase C-{delta}2011

Author(s)

Journal Title

Data Source

[Journal Article] All-trans retinoic acid and a novel synthetic retinoid tamibarotene (Am80) differentially regulate CD38 expression in human leukemia HL-60 cells: possible involvement of protein kinase C-{delta}2011

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Peroxisome proliferator-activated receptor-{gamma} suppresses CYP11B2 expression and aldosterone production2011

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Up-regulation of REG Iα accelerates tumor progression in pancreatic cancer with diabetes2010

Author(s)

Journal Title

Data Source

[Journal Article] チアゾリジン誘導体はPPARγおよびCa^<2+>/カルモジュリン依存性キナーゼ(CaMK)を介して副腎皮質癌R295R細胞におけるアルドステロン分泌を抑制する2010

Author(s)

Journal Title

Data Source

[Journal Article] FKBP12.6 disruption impairs glucose-induced insulin secretion2008

NOGUCHI Naoya 野口直哉