Nagai Kaoru 長井薫

… Alternative Names

NAGAI Kaoru 長井薫

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Researcher Number	20340953
Affiliation (Current)	2025: 京都府立大学, 生命環境科学研究科, 教授
Affiliation (based on the past Project Information) *help	2023 – 2025: 京都府立大学, 生命環境科学研究科, 教授 2018 – 2023: 千里金蘭大学, 生活科学部, 教授 2015 – 2017: 甲子園大学, 栄養学部, 教授 2014: 山梨大学, 総合研究部, 准教授 2012 – 2013: 山梨大学, 医学工学総合研究部, 准教授 … More 2006: 山梨大学, 大学院医学工学総合研究部, 助教授 2004 – 2005: 山梨大学, 大学院・医学工学総合研究部, 助教授 2002 – 2003: 兵庫医科大学, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator Basic Section 38050:Food sciences-related / Eating habits / Eating habits, studies on eating habits Except Principal Investigator Basic Section 38040:Bioorganic chemistry-related / Medium-sized Section 41:Agricultural economics and rural sociology, agricultural engineering, and related fields / Pediatrics / Basic Section 59040:Nutrition science and health science-related / Bioorganic chemistry / Environmental agriculture(including landscape science) / General physiology … More / General physiology / Bioproduction chemistry/Bioorganic chemistry / Biological Sciences / Anesthesiology/Resuscitation studies / Cerebral neurosurgery / General surgery Less
Keywords	Principal Investigator 認知症予防 / 機能性食品 / ミトコンドリア / 脂質 / レシチン / 酸化ストレス / 酪酸 / Hdac / 神経変性疾患 / ヒストン脱アセチル化酵素 … More / ケトン体 / リン脂質 / 大豆イソフラボン / ホスファチジルコリン / ニコチンアミドモノヌクレオチド / 食品機能 / 認知症 / 神経変性疾患予防 / 健康と食生活 … More Except Principal Investigator 神経膠細胞 / 天然物 / バイオレメディエーション / 白色腐朽菌 / MeCP2 / きのこ / 神経細胞保護効果 / 構造決定 / 構造活性相関 / 全合成 / PKA / Astrocyte / 蛋白質修飾 / ニューロン / Rett症候群 / 細胞内カルシウム / アセチルコリン / リグニンリファイナリー / 好気的水素産生 / 阻害剤 / 転写因子 / 食品成分 / 肥満 / 糖・脂質代謝 / ChREBP / 認知症予防 / 生合成 / ステロール / 医薬合成 / グリーン合成 / 菌類 / ワンポット反応 / 神経細胞保護 / 抗認知症薬 / 藻類 / 紅藻 / グリーンケミストリー / 合成 / 神経保護剤 / 抗認知症 / 毒性評価 / シトクロムP450 / 細胞保護 / 生物活性 / 有機化学 / 脂肪酸エステル / 立体特異的環縮小反応 / 絶対配置 / 神経保護効果 / ヘリセノン / 小胞体ストレス / アセトゲニン / ゲラニル-レゾルシノール / 微生物 / 細菌 / ネオニコチノイド / Adenosine A_<2a> receptor / Adenosine / Vesicular transport / Acetylcholine / Striatum / アデノシンA2a受容体 / アデノシン / 小胞輸送 / 線条体 / phosphorylation / glial cell / neuronal cell / DNA methylation / Rett syndrome / mental retardation / epigenetics / ノック / ノックアウトマウス / シナプス / 小児疾患 / 神経細胞 / DNAメチレーション / レット症候群 / 精神発達障害 / ゲノム不活化 / Glutamate release / Glutamate transporter / Protein kinase A / A_<2a> adenosine receptor / Neurotransmission / グルタミン酸放出 / グルタミン酸輸送担体 / 蛋白燐酸化酵素A / アデノシンA_<2a>受容体 / 情報伝達 / 分痔機構 / pleurocybellaziridine / 急性脳症 / スギヒラタケ / キノコ / グリア細胞 / 発生・分化 / 発現制御 / 脳神経疾患 / 神経科学 / 遺伝子 / 精神症状 / 小頭症 / グリア増殖 / 細胞内局在 / リン酸化修飾 / MeCP2蛋白 / P2Y受容体 / GABA放出 / GABA輸送担体 / シナプス外コリン伝達路 / ATP / ChAT / 移植 / 保存 / 臓器 / 蘇生 / 凍結 / 哺乳類細胞 / 遊離糖鎖 Less

GX実現に向けた白色腐朽菌の有するユニークな代謝系の全貌解明と有用菌の開発
- Principal Investigator
  
  平井浩文
- Project Period (FY)
  2025 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 41:Agricultural economics and rural sociology, agricultural engineering, and related fields
- Research Institution
  Shizuoka University
Collective Synthesis of Natural Products Associated with Health-Promoting Functions of Mushrooms and Evaluation of Their Biological Activities Aimed at Prevention of Dementia
- Principal Investigator
  
  小林正治
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 38040:Bioorganic chemistry-related
- Research Institution
  Osaka Institute of Technology
食品や代謝産物由来脂質類による神経変性疾患予防とミトコンドリア増強機構の解析Principal Investigator
- Principal Investigator
  
  長井薫
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 38050:Food sciences-related
- Research Institution
  Kyoto Prefectural University
食品成分によるChREBP活性化阻害を介したメタボリックシンドローム予防の解析
- Principal Investigator
  
  崎山晴彦
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Senri Kinran University
白色腐朽菌の環境汚染物質代謝能の意義解明及び汚染環境浄化への発展的応用
- Principal Investigator
  
  平井浩文
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 41:Agricultural economics and rural sociology, agricultural engineering, and related fields
- Research Institution
  Shizuoka University
Development of neuroprotective agents useful for the prevention and improvement of dementia
- Principal Investigator
  
  Kobayashi Shoji
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 38040:Bioorganic chemistry-related
- Research Institution
  Osaka Institute of Technology
食品や代謝産物由来脂質類による神経細胞抗老化および認知症予防に関する基礎的解析Principal Investigator
- Principal Investigator
  
  長井薫
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 38050:Food sciences-related
- Research Institution
  Kyoto Prefectural University
  Senri Kinran University
Study of the neuroprotective function of nutritional molecules via mitochondrial enhancementPrincipal Investigator
- Principal Investigator
  
  Nagai Kaoru
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 38050:Food sciences-related
- Research Institution
  Senri Kinran University
Collective total synthesis of unidentified natural products and structure-activity relationship on prevention of neurodegenerative disorder
- Principal Investigator
  
  Kobayashi Shoji
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bioorganic chemistry
- Research Institution
  Osaka Institute of Technology
Basic analysis for developing dementia preventing foods via regulating epigeneticsPrincipal Investigator
- Principal Investigator
  
  Nagai Kaoru
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Eating habits
- Research Institution
  Koshien University
Microbial degradation and detoxification of neonicotinoides by symbiotic systems of white-rot fungi with bacteria
- Principal Investigator
  
  Hirai Hirofumi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Environmental agriculture(including landscape science)
- Research Institution
  Shizuoka University
The molecular mechanism of Suguhiratake-acute encephalopathy;
- Principal Investigator
  
  KAWAGISHI Hirokazu
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Bioproduction chemistry/Bioorganic chemistry
- Research Institution
  Shizuoka University
Screening of novel therapeutic molecules against neurodegenerative diseases via modulation of Hdac activityPrincipal Investigator
- Principal Investigator
  
  NAGAI Kaoru
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Eating habits, studies on eating habits
- Research Institution
  University of Yamanashi
エピジェネティクス調節から探る小児自閉症の脳病態解明研究
- Principal Investigator
  
  KUBOTA Takeo
- Project Period (FY)
  2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  University of Yamanashi
エピジェネティクスに基づく小児自閉症の神経病態解明のための萌芽的アプローチ
- Principal Investigator
  
  久保田健夫
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Pediatrics
- Research Institution
  University of Yamanashi
Investigation of A Child Disease with Epigenetic Disorder -Rett Syndrome-
- Principal Investigator
  
  KUBOTA Takeo
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pediatrics
- Research Institution
  University of Yamanashi
Vesicular Acetylcholine Release from Astrocytes by Adenosine Signal
- Principal Investigator
  
  YAJIMA Yukio
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General physiology
- Research Institution
  Hyogo College of Medicine
細胞内遊離糖鎖を利用した移植臓器凍結蘇生法の開発
- Principal Investigator
  
  辻本三郎
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  General surgery
- Research Institution
  Hyogo Medical University
神経膠細胞を介したシナプス同調性シナプス外コリン伝達路の多次元解析
- Principal Investigator
  
  NAGATA Tetsu
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Hyogo Medical University
神経膠細胞シナプス外GABA分子伝達回路を標的とした催眠導入法の開発Principal Investigator
- Principal Investigator
  
  長井薫, 佐々木健
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  Hyogo Medical University
Inhibition of Astrocytic Glutamate Transporter and Stimulation of Glutamate Release from Astrocytes Mediated via an A_<2a> Adenosine Receptor/PKA Signaling Pathway
- Principal Investigator
  
  NISHIZAKI Tomoyuki
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General physiology
- Research Institution
  Hyogo College of Medicine

All 2024 2023 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2006 2005 Other

All Journal Article Presentation

[Journal Article] Soy isoflavone daidzein protects Neuro2a cells from NO stress via activation of AMPK-PGC1α pathway followed by mitochondrial enhancement.2023
- Author(s)
  Shogo Ito, Hiroko Sasaki, Takahiro Gotow, Isao Suetake, Kaoru Nagai
- Journal Title
  
  PharmaNutrition
  
  Volume: 24 Pages: 100337-100337
- DOI
  10.1016/j.phanu.2023.100337
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K05465, KAKENHI-PROJECT-22K06174
[Journal Article] Total Synthesis, Structure Revision and Neuroprotective Effect of Hericenones C-H and Their Derivatives2021
- Author(s)
  Kobayashi, S.; Tamura, T.; Koshishiba, M.; Yasumoto, T.; Shimizu, S.; Kintaka, T.; Nagai, K.
- Journal Title
  
  The Journal of Organic Chemistry
  
  Volume: 86 Issue: 3 Pages: 2602-2620
- DOI
  10.1021/acs.joc.0c02681
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K05407
[Journal Article] Total synthesis, structure revision, and neuroprotective effect of Hericenones C-H and their derivatives2021
- Author(s)
  Kobayashi S, Tamura T, Koshishiba M, Yasumoto T, Shimizu S, Kintaka T, Nagai K
- Journal Title
  
  The Journal of Organic Chemistry
  
  Volume: 86 Pages: 2602-2620
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K05542
[Journal Article] 大豆由来リン脂質による認知症予防の可能性2020
- Author(s)
  長井　薫, 伊藤　章悟
- Journal Title
  
  日本食品安全協会会誌
  
  Volume: 15 Pages: 212-218
- Data Source
  KAKENHI-PROJECT-18K05542
[Journal Article] Protective effects of nicotinamide mononucleotide against oxidative stressinduced PC12 cell death via mitochondrial enhancement2020
- Author(s)
  Ito S, Gotow T, Suetake I, Nagai K
- Journal Title
  
  PharmaNutrition
  
  Volume: 11 Pages: 100175-100175
- DOI
  10.1016/j.phanu.2019.100175
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K05542, KAKENHI-PROJECT-18K06095
[Journal Article] Total syntheses and endoplasmic reticulum stress suppressive activities of hericenes A－C and their derivatives2018
- Author(s)
  Kobayashi, S.*; Hamada, Y.; Yasumoto, T.; Hashino, Y.; Masuyama, A.; Nagai, K.*
- Journal Title
  
  Tetrahedron Lett.
  
  Volume: 59 Issue: 18 Pages: 1733-1736
- DOI
  10.1016/j.tetlet.2018.03.065
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K07779, KAKENHI-PROJECT-15K00814
[Journal Article] Bioremediation of the neonicotinoid insecticide clothianidin by the white-rot fungus Phanerochaete sordida2017
- Author(s)
  Toshio Mori, Jianqiao Wang, Yusuke Tanaka, Kaoru Nagai, Hirokazu Kawagishi, Hirofumi Hirai
- Journal Title
  
  Journal of Hazardous Materials
  
  Volume: 321 Pages: 586-590
- DOI
  10.1016/j.jhazmat.2016.09.049
- NAID
  120006501668
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H04618
[Journal Article] Cordyceps militaris improves the survival of Dahl salt-sensitive hypertensive rats possibly via influences of mitochondria and autophagy functions.2017
- Author(s)
  Takakura K(1), Ito S(1), Sonoda J(1), Tabata K, Shiozaki M, Nagai K, Shibata M, Koike M, Uchiyama Y, Gotow T
- Journal Title
  
  Heliyon
  
  Volume: 3 Issue: 11 Pages: e00462-e00462
- DOI
  10.1016/j.heliyon.2017.e00462
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08515, KAKENHI-PROJECT-17K08522, KAKENHI-PROJECT-15K00814
[Journal Article] Bioremediation of the neonicotinoid insecticide clothianidin by the white-rot fungus Phanerochaete sordida.2016
- Author(s)
  Mori T, Wang J, Tanaka Y, Nagai K, Kawagishi H, Hirai H.
- Journal Title
  
  J. Hazard. Mater.
  
  Volume: 321 Pages: 586-590
- NAID
  120006501668
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K00814
[Journal Article] Phytanic acid induces Neuro2a cell death via histone deacetylase activation and mitochondrial dysfunction.2015
- Author(s)
  Nagai K
- Journal Title
  
  Neurotoxicology and Teratology
  
  Volume: 48 Pages: 33-39
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24500972
[Journal Article] Histone deacetylase inhibitory effect of Brazilian propolis and its association with the anti-tumor effect in Neuro2a cells.2014
- Author(s)
  Ishiai S, Tahara W, Yamamoto E, Yamamoto R, Nagai K
- Journal Title
  
  Food Sci. Nutr.
  
  Volume: 2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24500972
[Journal Article] Histone deacetylase inhibitory effect of Brazilian propolis and its association with the anti-tumor effect in Neuro2a cells.2014
- Author(s)
  Ishiai S, Tahara W, Yamamoto E, Yamamoto R, Nagai K.
- Journal Title
  
  Food Science & Nutrition
  
  Volume: 2 Issue: 5 Pages: 565-570
- DOI
  10.1002/fsn3.131
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24500972
[Journal Article] Dilinoleoyl-phsphatidylethalamine from Hericium erinaceum protects against ER stress-dependent Neur2a cell death via protein kinase C pathway.2006
- Author(s)
  Nagai K, et al.
- Journal Title
  
  J Nutr Biochem Epub ahead of print
- Data Source
  KAKENHI-PROJECT-17025019
[Journal Article] A transcriptional repressor MeCP2 causing Rett syndrome is expressed in embryonic non-neuronal cells and controls their growth.2005
- Author(s)
  Nagai K, et al.
- Journal Title
  
  Brain Res Dev Brain Res 157・1
  
  Pages: 103-106
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390330
[Journal Article] A transcriptional represser MeCP2 causing Rett syndrome is expressed in embryonic non-neuronal cells and controls their growth.2005
- Author(s)
  Nagai K, et al.
- Journal Title
  
  Brain Res Dev Brain Res 157・1
  
  Pages: 103-106
- Data Source
  KAKENHI-PROJECT-15390330
[Journal Article] Dilinoleoyl-phsphatidylethalamine from Hericium erinaceum protects against ER stress-dependent Neur2a cell death via protein kinase C pathway.2005
- Author(s)
  Nagai K, et al.
- Journal Title
  
  J Nutr Biochem (Epub ahead of print)
  
  Pages: 2005-2005
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390330
[Journal Article] A transcriptional repressor MeCP2 causing Rett syndrome is expressed in embryonic non-neuronal cells and controls their growth.2005
- Author(s)
  Nagai K, Miyake K, Kubota T.
- Journal Title
  
  Brain Res Dev Brain Res 157
  
  Pages: 103-106
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390330
[Journal Article] A transcriptional repressor MeCP2 causing Rett syndrome is expressed in embryonic non-neuronal cells and controls their growth.2005
- Author(s)
  Nagai K, et al.
- Journal Title
  
  Brain Res Dev Brain Res 157・1
  
  Pages: 103-106
- Data Source
  KAKENHI-PROJECT-17659311
[Journal Article] A transcriptional repressor MeCP2 causing Rett syndrome is expressed in embryonic non-neuronal cells and controls their growth.2005
- Author(s)
  Nagai K, et al.
- Journal Title
  
  Brain Res Dev Brain Res 157・1
  
  Pages: 103-106
- Data Source
  KAKENHI-PROJECT-17025019
[Journal Article] Dilinoleoyl-phsphatidylethalamine from Hericium erinaceum protects against ER stress-dependent Neur2a cell death via protein kinase C pathway.2005
- Author(s)
  Nagai K, et al.
- Journal Title
  
  Nagai K, et al. Epub ahead of print
- Data Source
  KAKENHI-PROJECT-15390330
[Journal Article] Dilinoleoyl-phsphatidylethalamine from Hericium erinaceum protects against ER stress-dependent Neur2a cell death via protein kinase C pathway.2005
- Author(s)
  Nagai K, Chiba A, Nishino T, Kubota T, Kawagishi H.
- Journal Title
  
  J Nutr Biochem Oct 27;[Epub ahead of print]
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390330
[Presentation] 高活性リグニン分解菌Phanerochaete sordida YK-624によるネオニコチノイド系殺虫剤imidaclothiz代謝機構の解析2024
- Author(s)
  松浦瑠夏、殷茹、呉静、長井薫、森智夫、河岸洋和、平井浩文
- Organizer
  日本農芸化学会　2024年度大会
- Data Source
  KAKENHI-PROJECT-21H04744
[Presentation] 高活性リグニン分解菌Phanerochaete sordida YK-624株によるloxoprofen分解機構の解析2024
- Author(s)
  殷茹、呉静、長井薫、森智夫、河岸洋和、平井浩文
- Organizer
  日本農芸化学会　2024年度大会
- Data Source
  KAKENHI-PROJECT-21H04744
[Presentation] 高活性リグニン分解菌Phanerochaete sordida YK-624株による loxoprofen代謝機構の解明2023
- Author(s)
  殷茹、呉静、長井薫、森智夫、河岸洋和、平井浩文
- Organizer
  第68回リグニン討論会
- Data Source
  KAKENHI-PROJECT-21H04744
[Presentation] 不飽和脂肪酸エステルを有する天然物誘導体の神経細胞保護効果に関する研究2021
- Author(s)
  越柴瑞穂、小森純、竹林尚志、長井薫、小林正治
- Organizer
  第65回香料・テルペンおよび精油化学に関する討論会
- Data Source
  KAKENHI-PROJECT-21K05407
[Presentation] ヤマブシタケに由来するゲラニル-レゾルシノール類の全合成，構造訂正，および神経細胞保護効果2021
- Author(s)
  小林正治、田村朋葵、越柴瑞穂、安本健志、清水智志、長井薫
- Organizer
  第63回天然有機化合物討論会
- Data Source
  KAKENHI-PROJECT-21K05407
[Presentation] Synthesis of mushroom-derived linoleate-containing geranyl-resorcylates and their neuroprotective effects against ER stress-dependent cell death2021
- Author(s)
  Mizuho Koshishiba, Tomoki Tamura, Kaoru Nagai, Shoji Kobayashi
- Organizer
  The International Chemical Congress of Pacific Basin Societies 2021 (Pacifichem 2021)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K05407
[Presentation] Total synthesis, structure revision, and neuroprotective effect of geranyl-resorcylates derived from Hericium erinaceus2021
- Author(s)
  Shoji Kobayashi, Tomoki Tamura, Mizuho Koshishiba, Kaoru Nagai
- Organizer
  The International Chemical Congress of Pacific Basin Societies 2021 (Pacifichem 2021)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K05407
[Presentation] ジリノレオイルホスファチジルコリン(DLPC)によるミトコンドリア増強を介したNeuro2a細胞に対する酸化ストレスからの保護効果2020
- Author(s)
  長井薫、加留部真紀、中嶋新菜、八木夏海、山内加奈恵
- Organizer
  日本農芸化学会2020年度大会
- Data Source
  KAKENHI-PROJECT-18K05542
[Presentation] リノール酸エステルを含むヘリセノン類の合成と小胞体ストレス誘導神経細胞死に対する細胞保護効果2020
- Author(s)
  越柴瑞穂、田村朋葵、長井薫、小林正治
- Organizer
  日本化学会第100春季年会2020
- Data Source
  KAKENHI-PROJECT-17K07779
[Presentation] 酸化ストレスに対するダイゼインのAMPK活性化を介したミトコンドリア機能亢進作用による神経細胞保護効果2020
- Author(s)
  伊藤章吾、長井薫
- Organizer
  日本農芸化学会2020年度大会
- Data Source
  KAKENHI-PROJECT-18K05542
[Presentation] Soy isoflavone daidzein but not genistein protects Neuro2a cells from oxidative stress via AMPK and mitochondrial enhancement2019
- Author(s)
  Shogo Ito, Kaoru Nagai
- Organizer
  Annual Meeting of Society for Neuroscience
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K05542
[Presentation] ヤマブシタケに由来するゲラニル-レゾルシノール類の合成と神経細胞保護効果に関する構造活性相関研究2019
- Author(s)
  小林正治、田村朋葵、濱田彬希、越柴瑞穂、益山新樹、長井薫
- Organizer
  第63回香料・テルペンおよび精油化学に関する討論会
- Data Source
  KAKENHI-PROJECT-17K07779
[Presentation] Protective effects of nicotinamide mononucleotide against oxidative stress induced PC12 cell death via mitochondrial enhancement2019
- Author(s)
  Shogo Ito, Kaoru Nagai
- Organizer
  Annual Meeting of Society for Neuroscience
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K05542
[Presentation] NMN(ニコチンアミドモノヌクレオチド)のPC12細胞におけるミトコンドリア機能亢進を介した酸化ストレスからの細胞保護効果2018
- Author(s)
  伊藤章悟、長井薫
- Organizer
  平成30年度日本農芸化学会大会
- Data Source
  KAKENHI-PROJECT-15K00814
[Presentation] NMNのPC12細胞におけるミトコンドリア機能亢進を介した酸化ストレスからの細胞保護効果2017
- Author(s)
  伊藤章悟、長井薫
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-15K00814
[Presentation] 白色腐朽菌Phanerochaete sordida YK-624株によるクロチアニジンの分解2016
- Author(s)
  田中佑典、王剣橋、長井薫、森智夫、河岸洋和、平井浩文
- Organizer
  第66回日本木材学会大会
- Place of Presentation
  名古屋大学（愛知県名古屋市）
- Year and Date
  2016-03-27
- Data Source
  KAKENHI-PROJECT-15H04618
[Presentation] Cyto-protective and toxic effects of Cordyceps militaris and cordycepin on rat CNS neurons and PC12 cells.2016
- Author(s)
  2.Tabata K, Ito S, Sonoda J, Takakura K, Nagai K, Shiozaki M, Shibata M, Koike M, Uchiyama Y, Gotow T
- Organizer
  Annual Meeting of Society for Neuroscience
- Place of Presentation
  San Diego Convention Center
- Year and Date
  2016-11-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K00814
[Presentation] 高活性リグニン分解菌Phanerochaete sordida YK-624株によるネオニコチノイド系殺虫剤の分解及び無毒化2016
- Author(s)
  田中佑典、王剣橋、長井薫、森智夫、河岸洋和、平井浩文
- Organizer
  第61回リグニン討論会
- Place of Presentation
  京都大学宇治キャンパス（京都府、宇治市）
- Year and Date
  2016-10-27
- Data Source
  KAKENHI-PROJECT-15H04618
[Presentation] Histone deacetylase inhibitor MS-275 protects Neuro2a cells from endoplasmic reticulum stress via mitochondrial enhancement.2016
- Author(s)
  Nagai K, Shirazawa H.
- Organizer
  Annual Meeting of Society for Neuroscience
- Place of Presentation
  San Diego Convention Center
- Year and Date
  2016-11-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K00814
[Presentation] アントシアニンのヒストン脱アセチル化を介した神経細胞保護および神経突起伸長作用2014
- Author(s)
  名取　貴光, 長井　薫
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  国立京都国際会館(京都府京都市)
- Year and Date
  2014-10-18
- Data Source
  KAKENHI-PROJECT-24500972
[Presentation] Phytanic acid induces Neuro2a cell death via histone deacetylase activation.2014
- Author(s)
  Nagai K
- Organizer
  Annual Meeting of Society for Neuroscience
- Place of Presentation
  Washington DC (USA)
- Year and Date
  2014-11-16
- Data Source
  KAKENHI-PROJECT-24500972
[Presentation] フィタン酸はヒストン脱アセチル化酵素(Hdac)活性化とミトコンドリア障害を介しNeuro2a細胞に細胞死を誘導する2014
- Author(s)
  長井　薫, 名取　貴光
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  国立京都国際会館(京都府京都市)
- Year and Date
  2014-10-18
- Data Source
  KAKENHI-PROJECT-24500972
[Presentation] フィタン酸によるヒストン脱アセチル化酵素活性化作用2013
- Author(s)
  長井　薫
- Organizer
  日本農芸化学会2013年度大会
- Place of Presentation
  東北大学川内北キャンパス(宮城県)
- Data Source
  KAKENHI-PROJECT-24500972
[Presentation] ブラジル産プロポリス抽出物による小胞体ストレスからのNeuro2a細胞保護効果2013
- Author(s)
  石合　忍, 田原　渉, 山本　悦子, 山本　倫大, 長井　薫
- Organizer
  日本農芸化学会2013年度大会
- Place of Presentation
  東北大学川内北キャンパス(宮城県)
- Data Source
  KAKENHI-PROJECT-24500972
[Presentation] ブラジル産プロポリスによるヒストン脱アセチル化酵素活性制御と神経保護作用2012
- Author(s)
  石合　忍, 田原　渉, 山本　倫大, 長井　薫
- Organizer
  第35回日本神経科学会大会
- Place of Presentation
  名古屋国際会議場(愛知県)
- Data Source
  KAKENHI-PROJECT-24500972
[Presentation] Neuroprotective effect of Brazilian propolis extract via regulating Hdac activities.2012
- Author(s)
  Ishiai S, Tahara W, Yamamoto R, Nagai K.
- Organizer
  Annual Meeting of Society for Neuroscience
- Place of Presentation
  Ernest N. Memorial Convention Center (New Orleans, USA)
- Data Source
  KAKENHI-PROJECT-24500972
[Presentation] ポリフェノール類によるヒストン脱アセチル化酵素(Hdac)活性制御と神経機能調節
- Author(s)
  名取　貴光, 長井　薫
- Organizer
  日本農芸化学会2014年度大会
- Place of Presentation
  明治大学生田キャンパス (神奈川県川崎市)
- Data Source
  KAKENHI-PROJECT-24500972
[Presentation] フィタン酸はヒストン脱アセチル化酵素を活性化しNeuro2a細胞への小胞体ストレスを強める
- Author(s)
  長井　薫
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  パシフィコ横浜 (神奈川県横浜市)
- Data Source
  KAKENHI-PROJECT-24500972
[Presentation] Relationship of histone deacetylation and natural product-derived pigments exhibit anti-inflammatory activity and neuroprotective effects
- Author(s)
  名取　貴光, 長井　薫
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  パシフィコ横浜 (神奈川県横浜市)
- Data Source
  KAKENHI-PROJECT-24500972
[Presentation] Chemical Investigation of the Food-Poisoning Epidemics Caused by the Mushroom Pleurocybella porrigens
- Author(s)
  Tomohiro Suzuki, Saori Omae, Motohiro Fujita, Tomohiro Asakawa, Toshiyuki Wakimoto, Kaoru Nagai, Hirofumi Hirai, Toshiyuki Kan, Hirokazu Kawagishi
- Organizer
  13th International Conference on the Chemistry of Antibiotics and other bioactive compounds (ICCA)
- Place of Presentation
  富士ビューホテル（山梨県）
- Data Source
  KAKENHI-PROJECT-24248021
[Presentation] Protective effect of Brazilian propolis and its major component Artepillin C on endoplasmic reticulum stress induced Neuro2a cell death.
- Author(s)
  Ishiai S, Tahara W, Yamamoto R, Nagai K
- Organizer
  Annual Meeting of Society for Neuroscience
- Place of Presentation
  San Diego Convention Center (San Diego, USA)
- Data Source
  KAKENHI-PROJECT-24500972
[Presentation] Phytanic acid enhances histone deacetylase activity and vulnerability to endoplasmic reticulum stress in Neuro2a cells.
- Author(s)
  Nagai K
- Organizer
  Annual Meeting of Society for Neuroscience
- Place of Presentation
  San Diego Convention Center (San Diego, USA)
- Data Source
  KAKENHI-PROJECT-24500972
[Presentation] フィタン酸によるヒストン脱アセチル化酵素活性化を介したNeuro2a細胞に対する毒性作用
- Author(s)
  長井　薫
- Organizer
  日本農芸化学会2014年度大会
- Place of Presentation
  明治大学生田キャンパス (神奈川県川崎市)
- Data Source
  KAKENHI-PROJECT-24500972

1. NISHIZAKI Tomoyuki (00221474)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
2. HIRAI Hirofumi (70322138)

# of Collaborated Projects: 4 results

# of Collaborated Products: 7 results
3. YAJIMA Yukio (10068489)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. KUBOTA Takeo (70293511)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
5. Kobayashi Shoji (30374903)

# of Collaborated Projects: 3 results

# of Collaborated Products: 8 results
6. NAGATA Tetsu (60131588)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. KAWAGISHI Hirokazu (70183283)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
8. 太城力良 (20107048)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. 一瀬博文 (00432948)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. 亀井一郎 (90526526)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
11. KAN Toshiyuki (10221904)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
12. MORITA Tatsuya (90332692)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. ENDOH Kazushi (70176791)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. KOHSAKA Shin-ichi (50112686)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. ITOH Masayuki (50243407)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. GOTO Yu-ichi (20225668)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. YAMAMOTO Satoshi (60220464)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 辻本三郎 (00144254)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 有田憲生 (80159508)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 佐々木健 (20340979)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 王培玉 (10283201)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 鈴木智大 (10649601)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 森智夫 (80536516)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
24. 崎山晴彦 (30508958)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. 藤原範子 (10368532)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. 鎌田洋一 (20152837)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. 八木千鶴 (20425086)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. 江口裕伸 (60351798)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. 長尾遼 (30633961)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
30. 小野晶子 (60975473)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
31. 柴田昌宏

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Nagai Kaoru 長井 薫

NAGAI Kaoru 長井 薫

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食品や代謝産物由来脂質類による神経変性疾患予防とミトコンドリア増強機構の解析Principal Investigator

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食品や代謝産物由来脂質類による神経細胞抗老化および認知症予防に関する基礎的解析Principal Investigator

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Study of the neuroprotective function of nutritional molecules via mitochondrial enhancementPrincipal Investigator

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Basic analysis for developing dementia preventing foods via regulating epigeneticsPrincipal Investigator

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Screening of novel therapeutic molecules against neurodegenerative diseases via modulation of Hdac activityPrincipal Investigator

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Nagai Kaoru 長井薫

NAGAI Kaoru 長井薫