Itoh Hiroshi 伊藤洋志

… Alternative Names

ITOU Hiroshi 伊藤洋志

伊藤洋志イトウヒロシ

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Researcher Number	20362387
Other IDs
Affiliation (Current)	2025: 神戸常盤大学, 保健科学部, 教授
Affiliation (based on the past Project Information) *help	2023: 神戸常盤大学, 保健科学部, 教授 2016 – 2022: 長浜バイオ大学, バイオサイエンス学部, 准教授 2014 – 2015: 京都大学, 医学(系)研究科(研究院), 助教 2013: 京都大学, 医学研究科, 助教 2011: 京都大学, 医学研究科, 助教 2005 – 2006: 京都大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Infectious disease medicine / Basic Section 54030:Infectious disease medicine-related Except Principal Investigator Laboratory medicine / Pediatrics / 膠原病・アレルギー・感染症内科学
Keywords	Principal Investigator 自然免疫 / オートファジー / 好中球 / 細胞死 / IL-8 / 炎症 / 感染症 / 多剤耐性菌 / S100A8/S100A9 / DAMPS … More / ミトコンドリア / S100A8/A9 / 易感染性宿主 / 免疫グロブリン / 貪食 / 易感染宿主 / 殺菌能 … More Except Principal Investigator 微小残存病変 / 新規予後因子 / 好中球 / S100 protein / recombinant protein / regulation / immune function / macrophages / 炎症 / エンドサイトーシス / 核内移行 / 組み換えタンパク質 / 複合体 / NF-kappa B / S100タンパク質 / 免疫複合体 / 難病 / 組換えタンパク質 / 強皮症 / 間質性肺炎 / 炎症性サイトカイン / マクロファージ / 骨髄異形成症候群 / 白血病 / 血液標本 / 遺伝子解析 / フローサイトメトリー / 急性骨髄性白血病 / 臨床血液学 / 遺伝子発現 / 遺伝子変異 / 細胞死 / 白血病幹細胞 / オートファジー / アポトーシス / 難治性血液腫瘍 / 感染症 / DDS / 抗菌薬 Less

Elucidation of mechanisms on regulating neutrophil functions mediated by autocrine through autophagy.Principal Investigator
- Principal Investigator
  
  伊藤洋志
- Project Period (FY)
  2019 – 2024
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 54030:Infectious disease medicine-related
- Research Institution
  Kobe Tokiwa University
  Nagahama Institute of Bio-Science and Technology
High-order mechanism for regulating immune function of macrophages using a new recombinant protein and its clinical application
- Principal Investigator
  
  Ikemoto Masaki
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Nagahama Institute of Bio-Science and Technology
Regulation of neutrophil functions mediated by an autophagy machinery against multi-drug resistant bacterial infectionPrincipal Investigator
- Principal Investigator
  
  Itoh Hiroshi
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Infectious disease medicine
- Research Institution
  Nagahama Institute of Bio-Science and Technology
Development of novel therapies using neutrophil functions mediated by the autophagy machinery against multi-drug resistant bacterial infectionsPrincipal Investigator
- Principal Investigator
  
  ITOH Hiroshi
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Infectious disease medicine
- Research Institution
  Kyoto University
Establishment of new extraction system from bone marrow smear by laser microdissection
- Principal Investigator
  
  ADACHI Souichi
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Laboratory medicine
- Research Institution
  Kyoto University
Development of new tharapy and search for new cell death mechanism in hematologic malignancies
- Principal Investigator
  
  ADACHI Souichi
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pediatrics
- Research Institution
  Kyoto University
Establishment of detection system of MRD by FACS and analysis of leukemic stem cells in AML
- Principal Investigator
  
  ADACHI Souichi
- Project Period (FY)
  2011
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Laboratory medicine
- Research Institution
  Kyoto University
好中球を利用した抗菌薬を感染病巣に到達させる特異的DDSの開発
- Principal Investigator
  
  笹田昌孝
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  Kyoto University

All 2022 2020 2019 2018 2016 2015 2014 2013 2006 Other

All Journal Article Presentation

[Journal Article] Circulating S100A8/A9 is potentially a biomarker that could reflect the severity of experimental colitis in rats2020
- Author(s)
  Kohki Okada, Hiroshi Itoh, Masaki Ikemoto
- Journal Title
  
  Heliyon
  
  Volume: 6 Issue: 2 Pages: e03470-e03470
- DOI
  10.1016/j.heliyon.2020.e03470
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K15786, KAKENHI-PROJECT-17K08999
[Journal Article] Serum S100A8/A9 as a potentially sensitive biomarker for inflammatory bowel diseases2019
- Author(s)
  Kohki Okada, Makoto Okabe, Yuto Kimura, Kohsuke Doi, Hiroshi Itoh, and Masaki Ikemoto
- Journal Title
  
  Lab Med
  
  Volume: 50 Issue: 4 Pages: 370-380
- DOI
  10.1093/labmed/lmz003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08999
[Journal Article] Establishment of S100A8 Transgenic Rats to Understand Innate Property of S100A8 and Its Immunological Role2018
- Author(s)
  Okada Kohki、Itoh Hiroshi、Kamikubo Yasuhiko、Adachi Souichi、Ikemoto Masaki
- Journal Title
  
  Inflammation
  
  Volume: 41 Issue: 1 Pages: 59-72
- DOI
  10.1007/s10753-017-0664-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09932, KAKENHI-PROJECT-17K15786, KAKENHI-PROJECT-17K08999
[Journal Article] CD68 on rat macrophages binds tightly to S100A8 and S100A9 and helps to regulate the cells' immune functions.2016
- Author(s)
  Okada K, Arai S, Itoh H, Adachi S, Hayashida M, Nakase H, Ikemoto M
- Journal Title
  
  Journal of Leukocyte Biology
  
  Volume: 100 Issue: 5 Pages: 1093-1104
- DOI
  10.1189/jlb.2a0415-170rrr
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09932
[Journal Article] CXCR4 overexpression is a poor prognostic factor in pediatric acute myeloid leukemia with low risk: a report from the Japanese Pediatric Leukemia/Lymphoma Study Group2016
- Author(s)
  Matsuo H, Nakamura N, Tomizawa D, Saito AM, Kiyokawa N, Horibe K, Nishinaka-Arai Y, Tokumasu M, Itoh H, Kamikubo Y, Nakayama H, Kinoshita A, Taga T, Tawa A, Taki T, Tanaka S, Adachi S
- Journal Title
  
  Pediatr Blood Cancer
  
  Volume: 63 Issue: 8 Pages: 1394-1399
- DOI
  10.1002/pbc.26035
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09486, KAKENHI-PROJECT-16K09932, KAKENHI-PROJECT-16K19193
[Journal Article] Intravenous immunoglobulin enhances the killing activity and autophagy of neutrophils isolated from immunocompromised patients against multidrug-resistant bacteria.2015
- Author(s)
  Matsuo H, Itoh H, Kitamura N, Kamikubo Y, Higuchi T, Shiga S, Ichiyama S, Kondo T, Takaori-Kondo A, Adachi S.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 464 Issue: 1 Pages: 94-9
- DOI
  10.1016/j.bbrc.2015.06.004
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25461420, KAKENHI-PROJECT-26670484
[Journal Article] Autocrine pathways involving S100A8 and/or S100A9 that are postulated to regulate the immunological functions of macrophages in rats.2015
- Author(s)
  Okada K, Arai S, Nakase H, Kohno H, Nakamura F, Takeda M, Toda Y, Itoh H, Adachi S, Ikemoto M
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 456 Issue: 1 Pages: 415-420
- DOI
  10.1016/j.bbrc.2014.11.099
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26670484
[Journal Article] Adverse prognostic impact of KIT mutations in childhood CBF-AML: the results of the Japanese Pediatric Leukemia/Lymphoma Study Group AML-05 trial.2015
- Author(s)
  Tokumasu M, Murata C, Shimada A, Ohki K, Hayashi Y, Saito AM, Fujimoto J, Horibe K, Nagao M, Itoh H, Kamikubo Y, Nakayama H, Kinoshita A, Tomizawa D, Taga T, Tawa A, Tanaka S, Heike T, Adachi S
- Journal Title
  
  Leukemia
  
  Volume: 29 Issue: 12 Pages: 2438-2441
- DOI
  10.1038/leu.2015.121
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26461599, KAKENHI-PROJECT-25461420, KAKENHI-PROJECT-25461611, KAKENHI-PROJECT-25670482, KAKENHI-PROJECT-26670484
[Journal Article] Enhancement of neutrophil autophagy by an IVIG preparation against　multi-drug-resistant bacteria as well as drug sensitive strains.2015
- Author(s)
  Itoh H, Matsuo H, Kitamura N, Yamamoto S, Higuchi T, Takematsu H, Kamikubo Y, Kondo T, Yamashita K, Sasada M, Takaori-Kondo A, Adachi S.
- Journal Title
  
  Journal of Leukocyte Biology
  
  Volume: 98 Issue: 1 Pages: 107-117
- DOI
  10.1189/jlb.4a0813-422rrr
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09499, KAKENHI-PROJECT-25461420, KAKENHI-PROJECT-26670484
[Journal Article] Reduced intensity conditioning in allogeneic stem cell transplantation for AML with Down syndrome.2014
- Author(s)
  Muramatsu H, Sakaguchi H, Taga T, Tabuchi K, Adachi S, Inoue M, Kitoh T, Suminoe A, Yabe H, Azuma E, Shioda Y, Ogawa A, Kinoshita A, Kigasawa H, Osugi Y, Koike K, Kawa K, Kato K, Atsuta Y, Kudo K.
- Journal Title
  
  Pediatr Blood Cancer
  
  Volume: 61 Issue: 5 Pages: 925-927
- DOI
  10.1002/pbc.24883
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390273, KAKENHI-PROJECT-24590713, KAKENHI-PROJECT-24791054
[Journal Article] EVI1 overexpression is a poor prognostic factor in pediatric patients with mixed lineage leukemia-AF9 rearranged acute myeloid leukemia.2014
- Author(s)
  Matsuo H, Kajihara M, Tomizawa D, Watanabe T, Saito AM, Fujimoto J, Horibe K, Kodama K, Tokumasu M, Itoh H, Nakayama H, Kinoshita A, Taga T, Tawa A, Taki T, Shiba N, Ohki K, Hayashi Y, Yamashita Y, Shimada A, Tanaka S, Adachi S.
- Journal Title
  
  Haematologica
  
  Volume: 99 Issue: 11 Pages: 225-227
- DOI
  10.3324/haematol.2014.107128
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24390268, KAKENHI-PROJECT-24591407, KAKENHI-PROJECT-25670482, KAKENHI-PROJECT-25893028, KAKENHI-PROJECT-26461598, KAKENHI-PROJECT-26461599, KAKENHI-PROJECT-26670277, KAKENHI-PROJECT-26670484
[Journal Article] Prognostic implications of CEBPA mutations in pediatric acute myeloid leukemia: a report from the Japanese Pediatric Leukemia/Lymphoma Study Group.2014
- Author(s)
  Matsuo H, Kajihara M, Tomizawa D, Watanabe T, Saito AM, Fujimoto J, Horibe K, Kodama K, Tokumasu M, Itoh H, Nakayama H, Kinoshita A, Taga T, Tawa A, Taki T, Tanaka S, Adachi S.
- Journal Title
  
  Blood Cancer J
  
  Volume: 4 Issue: 7 Pages: e226-e226
- DOI
  10.1038/bcj.2014.47
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24591407, KAKENHI-PROJECT-26670277, KAKENHI-PROJECT-26670484
[Journal Article] 薬剤による白血球機能障害2006
- Author(s)
  笹田昌孝, 伊藤洋志, 山下浩平
- Journal Title
  
  血液フロンティア 16(10)
  
  Pages: 1625-1630
- Data Source
  KAKENHI-PROJECT-17659300
[Journal Article] Prognostic implications of CEBPA mutations in pediatric acute myeloid leukemia : A report from the Japanese Pediatric Leukemia/Lymphoma Study Group
- Author(s)
  Matsuo H, Itoh H, Adachi S, et al
- Journal Title
  
  Blood Cancer Journal
  
  Volume: (in press)
- Data Source
  KAKENHI-PROJECT-23390273
[Journal Article] Prognostic implications of CEBPA mutations in pediatric acute myeloid leukemia : A report from the Japanese Pediatric Leukemia/Lymphoma Study Group
- Author(s)
  Matsuo H, Itoh H, Adachi S, et al.
- Journal Title
  
  Blood Cancer Journal
  
  Volume: (in press)
- Data Source
  KAKENHI-PROJECT-24659273
[Presentation] ミトコンドリアタンパク質由来ペプチド「マイトクリプタイド」によるヒト好中球の機能発現の検討2022
- Author(s)
  小森美咲　岡田光貴　伊藤洋志
- Organizer
  第69回日本臨床検査医学会学術集会
- Data Source
  KAKENHI-PROJECT-19K17942
[Presentation] 炎症性腸疾患患者の血清中S100A8/A9の測定意義について-疾患の臨床的重症度との比較を通して2019
- Author(s)
  岡田光貴、伊藤洋志、池本正生
- Organizer
  第68回日本医学検査学会
- Data Source
  KAKENHI-PROJECT-16K09932
[Presentation] 遺伝子組み換えタンパク質によるマクロファージ機能の超制御機構とその臨床応用2018
- Author(s)
  岡田光貴，伊藤洋志，池本正生
- Organizer
  第65回　日本臨床検査医学会学術集会
- Data Source
  KAKENHI-PROJECT-17K08999
[Presentation] 遺伝子組み換えタンパク質によるマクロファージ機能の超制御機構とその臨床応用2018
- Author(s)
  岡田光貴、伊藤洋志、池本正生
- Organizer
  第65回日本臨床検査医学会学術集会
- Data Source
  KAKENHI-PROJECT-16K09932
[Presentation] ヒト前骨髄球性白血病細胞株HL60を用いたオートファジー解析実験系の確立2015
- Author(s)
  伊藤洋志、山本翔、谷村志桜里、上久保靖彦、足立壯一
- Organizer
  第26回日本生体防御学会学術総会
- Place of Presentation
  台東区生涯学習センター　ミレニアムホール
- Year and Date
  2015-07-10
- Data Source
  KAKENHI-PROJECT-26670484
[Presentation] 血液疾患の予後因子をスメア標本より検出するシステムの確立2013
- Author(s)
  松尾英将、池内絢香、志賀修一、土岐力、照井君典、伊藤悦朗、足立壮一
- Organizer
  第8回日本臨床検査学教育学会学術大会
- Place of Presentation
  大阪市
- Data Source
  KAKENHI-PROJECT-24659273
[Presentation] Prognostic impact of KIT mutation in t(8;21) childhood AML : The JPLSG AML-05 trial2013
- Author(s)
  Tokumasu M, Itoh H, Adachi S, et al
- Organizer
  第75回日本血液学会学術集会
- Place of Presentation
  札幌市
- Data Source
  KAKENHI-PROJECT-23390273
[Presentation] Investigation of the clinical significance of CEBPA mutation in child AML : The JPLSG AML-05 study2013
- Author(s)
  Matsuo H, Itoh H, Adachi S, et al
- Organizer
  第75回日本血液学会学術集会
- Place of Presentation
  札幌市
- Data Source
  KAKENHI-PROJECT-23390273
[Presentation] 真菌感染症の治療における好中球の殺菌能の意義
- Author(s)
  北村奈緒子、山本翔、伊藤洋志、足立壯一
- Organizer
  日本Cell Death学会
- Place of Presentation
  東京医科歯科大学鈴木章夫記念講堂（東京都文京区）
- Year and Date
  2014-07-18 – 2014-07-19
- Data Source
  KAKENHI-PROJECT-26670484
[Presentation] 好中球の殺菌能におけるオートファジー機構の役割
- Author(s)
  伊藤洋志、北村奈緒子、山本翔、松尾英将、足立壯一
- Organizer
  日本生体防御学会
- Place of Presentation
  東北大学片平さくらホール（宮城県仙台市青葉区）
- Year and Date
  2014-07-09 – 2014-07-11
- Data Source
  KAKENHI-PROJECT-26670484

1. ADACHI Souichi (10273450)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
2. WATANABE Ken-itirou (20324634)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. IWAMOTO Shoutarou (20456734)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. Ikemoto Masaki (80144385)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
5. 笹田昌孝 (30144364)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. 藤井信孝 (60109014)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 岡田光貴 (80747569)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
8. OHKI Kentaro

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
9. YAMASHITA Kouhei

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 足立壮一

# of Collaborated Projects: 0 results

# of Collaborated Products: 10 results
11. 上久保靖彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 滝智彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
13. 林泰秀

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Itoh Hiroshi 伊藤 洋志

ITOU Hiroshi 伊藤 洋志

伊藤 洋志 イトウ ヒロシ

Research Projects

Research Products

Co-Researchers

Elucidation of mechanisms on regulating neutrophil functions mediated by autocrine through autophagy.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

High-order mechanism for regulating immune function of macrophages using a new recombinant protein and its clinical application

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Regulation of neutrophil functions mediated by an autophagy machinery against multi-drug resistant bacterial infectionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of novel therapies using neutrophil functions mediated by the autophagy machinery against multi-drug resistant bacterial infectionsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Establishment of new extraction system from bone marrow smear by laser microdissection

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of new tharapy and search for new cell death mechanism in hematologic malignancies

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Establishment of detection system of MRD by FACS and analysis of leukemic stem cells in AML

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

好中球を利用した抗菌薬を感染病巣に到達させる特異的DDSの開発

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Circulating S100A8/A9 is potentially a biomarker that could reflect the severity of experimental colitis in rats2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Serum S100A8/A9 as a potentially sensitive biomarker for inflammatory bowel diseases2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Establishment of S100A8 Transgenic Rats to Understand Innate Property of S100A8 and Its Immunological Role2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] CD68 on rat macrophages binds tightly to S100A8 and S100A9 and helps to regulate the cells' immune functions.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] CXCR4 overexpression is a poor prognostic factor in pediatric acute myeloid leukemia with low risk: a report from the Japanese Pediatric Leukemia/Lymphoma Study Group2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Intravenous immunoglobulin enhances the killing activity and autophagy of neutrophils isolated from immunocompromised patients against multidrug-resistant bacteria.2015

Itoh Hiroshi 伊藤洋志

ITOU Hiroshi 伊藤洋志

伊藤洋志イトウヒロシ

[Journal Article] Enhancement of neutrophil autophagy by an IVIG preparation against　multi-drug-resistant bacteria as well as drug sensitive strains.2015