TAKAHASHI Hisaaki 高橋寿明

… Alternative Names

Takahashi Hisaaki 高橋寿明

高橋寿明タカハシヒサアキ

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Researcher Number	20363228
Other IDs
Affiliation (Current)	2025: 北陸大学, 薬学部, 教授
Affiliation (based on the past Project Information) *help	2016 – 2024: 北陸大学, 薬学部, 教授 2015 – 2017: 旭川医科大学, 医学部, 准教授 2011 – 2013: 愛媛大学, 医学(系)研究科(研究院), 講師 2012: 愛媛大学, 医学部附属病院, 講師 2009 – 2011: Ehime University, 大学院・医学系研究科, 講師 … More 2007: Ehime University, 大学院・医学系研究科, 講師 2006: 愛媛大学, 大学院医学系研究科, 講師 2006: 愛媛大学, 大学院医学部研究科, 講師 2005: 愛媛大, 医学部, 助手 2004: 愛媛大学, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator Cerebral neurosurgery / Basic Section 56010:Neurosurgery-related / Neurosurgery Except Principal Investigator Cerebral neurosurgery / Orthopaedic surgery / Medical systems / General physiology
Keywords	Principal Investigator グリオーマ / 腫瘍幹細胞 / Oct-3/4 / 浸潤 / 膠芽腫 / グリオブラストーマ / マイクログリア / 抗体医薬品 / CasMab法 / CD90 … More / 腫瘍血管 / 分子標的治療薬 / cdc2 / 細胞周期 / IDO / TDO / AMPK / 腫瘍免疫 / ABCトランスポーター / DNAメチル化 / テモゾロミド / MGMT / 薬剤耐性 / 化合物スクリーニング / AKT / HIF1 / VEGF / 血管新生 / マトリックスメタロプロテアーゼ / ヘパラナーゼ / 脳梗塞 / 細胞系譜 / トランスジェニックマウス / 遺伝子欠損マウス / アクチン細胞骨格 / LIMキナーゼ … More Except Principal Investigator マイクログリア / BINCs / 脳損傷 / 骨髄 / マクロファージ / 脳梗塞 / アストロサイト / GFAP / 細胞移植 / NG2 / トランスジェニックマウス / oligodendrocyte / astrocyte / transdifferentiation / microglia / 脊髄損傷 / 神経組織再生 / 分化転換 / オリゴデンドロサイト / 神経系前駆細胞 / 神経細胞 / 手術支援 / 可視化 / 蛍光画像 / アミノレブリン酸 / 脳腫瘍 / 光線力学的診断 / nestin / regenerative medicine / NG2コンドロイチン硫酸ブロテオグリカン / NG2コンドロイチン硫酸プロテオグリカン / 多能性幹細胞 / 分化誘導 / サイトカイン / Iba1 / 幹細胞性 / 新規治療法 / パーキンソン病 / 単球 / 神経細胞保護作用 / 分化多能性 / Cre / 脳虚血 / 損傷修復 / HSV-tk / アストログリオーシス / 幹細胞 / NG2プロテオグリカン / Ibal / ProMGB / neuron / spinal cord / regeneration Less

腫瘍血管を特異的に破壊する悪性グリオーマ新規抗体治療薬の開発Principal Investigator
- Principal Investigator
  
  高橋寿明
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  Hokuriku University
Development of molecular-targeted therapeutic drugs for malignant glioma that enable reactivation of tumor immunityPrincipal Investigator
- Principal Investigator
  
  Takahashi Hisaaki
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  Hokuriku University
微弱蛍光の可視化と数値情報の提示によって脳腫瘍切除手術を支援するシステムの構築
- Principal Investigator
  
  竹内文也
- Project Period (FY)
  2015 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical systems
- Research Institution
  Asahikawa Medical College
Development of Oct-3/4 targeting drug for malignant glioma treatmentPrincipal Investigator
- Principal Investigator
  
  Takahashi Hisaaki
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurosurgery
- Research Institution
  Hokuriku University
  Asahikawa Medical College
Oct-3/4 promotes tumor angiogenesis through VEGF production in glioblastomaPrincipal Investigator
- Principal Investigator
  
  HISAAKI Takahashi
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Ehime University
Determination of cell type(s) that should be transplanted into lesion core of the brain for better outcome
- Principal Investigator
  
  TANAKA Junya
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Ehime University
Multipotential stem cell-like nature of bone marrow-derived macrophages accumulated in lesion core of acute and severe brain injuries.
- Principal Investigator
  
  TANAKA Junya
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General physiology
- Research Institution
  Ehime University
Involvement of cancer stem cells in the failure of curative treatmentPrincipal Investigator
- Principal Investigator
  
  TAKAHASHI Hisaaki
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Ehime University
Cre-Loxpシステムを用いたマイクログリアの細胞系譜解析と脳腫瘍研究への応用Principal Investigator
- Principal Investigator
  
  高橋寿明
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Ehime University
トランスジェニックマウスを用いたマイクログリアによる脳損傷修復システムの解明
- Principal Investigator
  
  田中潤也
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Ehime University
脳傷害部位へ遊走するマイクログリアの細胞内分子メカニズムの解明Principal Investigator
- Principal Investigator
  
  高橋寿明
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Ehime University
Development of novel therapeutic means to regenerating spinal cord injury using microglia/macrophages
- Principal Investigator
  
  TANAKA Junya
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  EHIME UNIVERSITY
革命的脊髄損傷治療法の開発:骨髄細胞あるいは末梢血から中枢神経組織を作る
- Principal Investigator
  
  TANAKA Junya
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Ehime University

[Journal Article] Identification of CD44 as a Reliable Biomarker for Glioblastoma Invasion: Based on Magnetic Resonance Imaging and Spectroscopic Analysis of 5-Aminolevulinic Acid Fluorescence2023
- Author(s)
  Inoue Akihiro、Ohnishi Takanori、Nishikawa Masahiro、Watanabe Hideaki、Kusakabe Kosuke、Taniwaki Mashio、Yano Hajime、Ohtsuka Yoshihiro、Matsumoto Shirabe、Suehiro Satoshi、Yamashita Daisuke、Shigekawa Seiji、Takahashi Hisaaki、Kitazawa Riko、Tanaka Junya、Kunieda Takeharu
- Journal Title
  
  Biomedicines
  
  Volume: 11 Issue: 9 Pages: 2369-2369
- DOI
  10.3390/biomedicines11092369
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K19543, KAKENHI-PROJECT-21K09178, KAKENHI-PROJECT-22K09208, KAKENHI-PROJECT-20K09333
[Journal Article] Generation of CSF1-Independent Ramified Microglia-Like Cells from Leptomeninges In Vitro2020
- Author(s)
  Tanaka J, Takahashi H, Yano H, Nakanishi H.
- Journal Title
  
  Cells
  
  Volume: 10 Issue: 1 Pages: 24-37
- DOI
  10.3390/cells10010024
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K09333, KAKENHI-PROJECT-18K19650, KAKENHI-PROJECT-20K21465
[Journal Article] Significance of Glioma Stem-Like Cells in the Tumor Periphery That Express High Levels of CD44 in Tumor Invasion, Early Progression, and Poor Prognosis in Glioblastoma.2018
- Author(s)
  Masahiro Nishikawa, Akihiro Inoue, Takanori Ohnishi, Shohei Kohno, Shiro Ohue, Shirabe Matsumoto, Satoshi Suehiro, Daisuke Yamashita, Saya Ozaki, Hideaki Watanabe, Hajime Yano, Hisaaki Takahashi, Riko Kitazawa, Junya Tanaka, Takeharu Kunieda
- Journal Title
  
  Stem Cells International
  
  Volume: 23 Pages: 5387041-5387041
- DOI
  10.1155/2018/5387041
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08997, KAKENHI-PROJECT-15K10324
[Journal Article] Truncated CD200 stimulates tumor immunity leading to fewer lung metastases in a novel Wistar rat metastasis model2018
- Author(s)
  Kuwabara Jun、Umakoshi Akihiro、Abe Naoki、Sumida Yutaro、Ohsumi Shota、Usa Eika、Taguchi Kana、Choudhury Mohammed E.、Yano Hajime、Matsumoto Shirabe、Kunieda Takeharu、Takahashi Hisaaki、Yorozuya Toshihiro、Watanabe Yuji、Tanaka Junya
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 496 Issue: 2 Pages: 542-548
- DOI
  10.1016/j.bbrc.2018.01.065
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K10809, KAKENHI-PROJECT-16K20014, KAKENHI-PROJECT-18K16587, KAKENHI-PROJECT-17K16650, KAKENHI-PROJECT-15K10324
[Journal Article] Blood vessels expressing CD90 in human and rat brain tumors2016
- Author(s)
  Akihiro Inoue, Junya Tanaka, Hisaaki Takahashi, Shohei Kohno, Shiro Ohue, Akihiro Umakoshi, Katsuhiro Gotoh, Takanori Ohnishi
- Journal Title
  
  Neuropathology
  
  Volume: 36 Issue: 2 Pages: 168-180
- DOI
  10.1111/neup.12244
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K14351, KAKENHI-PROJECT-15K10324
[Journal Article] Treadmill exercise ameliorates ischemia-induced brain edema while suppressing Na+/H+ exchanger 1 expression2016
- Author(s)
  Ryutaro Nishioka, Kana Sugimoto, Hitomi Aono, Ayano Mise, Mohammed E. Choudhury, Kazuya Miyanishi, Afsana Islam, Takahiro Fujita, Haruna Takeda, Hisaaki Takahashi, Hajime Yano, Junya Tanaka
- Journal Title
  
  Experimental Neurology
  
  Volume: 277 Pages: 150-161
- DOI
  10.1016/j.expneurol.2015.12.016
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K10809, KAKENHI-PROJECT-26861150, KAKENHI-PROJECT-15K14351, KAKENHI-PROJECT-15K10324, KAKENHI-PROJECT-16K10721
[Journal Article] The hypnotic bromovalerylurea ameliorates 6-hydroxydopamine-induced dopaminergic neuron loss while suppressing expression of interferon regulatory factors by microglia2016
- Author(s)
  Hiromi Higaki, Mohammed Emamussalehin Choudhury, Chisato Kawamoto, Keisuke Miyamoto, Afsana Islam, Yurika Ishii, Kazuya Miyanishi, Haruna Takeda, Naoto Seo, Kana Sugimoto, Hisaaki Takahashi, Hajime Yano and Junya Tanaka
- Journal Title
  
  Neurochemistry International
  
  Volume: 99 Pages: 158-168
- DOI
  10.1016/j.neuint.2016.06.013
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K14351, KAKENHI-PROJECT-26861150, KAKENHI-PROJECT-15K10324, KAKENHI-PROJECT-15K10809, KAKENHI-PROJECT-16K10721
[Journal Article] CD200+ and CD 200- macrophages accumulated in ischemic lesions of rat brain: The two populations cannot be classified as either M1 or M2 macrophages2015
- Author(s)
  Shirabe Matsumoto, Junya Tanaka, Hajime Yano, Hisaaki Takahashi, Kana Sugimoto, Shiro Ohue, Akihiro Inoue, Hitomi Aono, Akari Kusakawa, Hideaki Watanabe, Yoshiaki Kumon, Takanori Ohnishi
- Journal Title
  
  Journal of Neuroimmunology
  
  Volume: 282 Pages: 7-20
- DOI
  10.1016/j.jneuroim.2015.03.013
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26462162, KAKENHI-PROJECT-26861150, KAKENHI-PROJECT-15K10324, KAKENHI-PROJECT-15K10809, KAKENHI-PROJECT-15K14351
[Journal Article] miR-340 acts as atumor suppressor in tumorigenesis of human glioma-initiating cells by targeting plasminogen activator, tissue.2015
- Author(s)
  Yamashita D, Kondo T, Ohue S, Takahashi H, Ishikawa M, Matoba R, Suehiro A, Inoue A, Kohno S, Harada H, Tanaka J, Ohnishi T
- Journal Title
  
  Cancer Research
  
  Volume: 75 Pages: 1123-1133
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K10324
[Journal Article] Postnatal interleukin-1beta administration after experimental prolonged febrile seizures enhances epileptogenesis in adulthood2015
- Author(s)
  Fukuda, M, Ishii, E, et al.
- Journal Title
  
  Metab Brain Dis
  
  Volume: in press Issue: 3 Pages: 813-819
- DOI
  10.1007/s11011-014-9648-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26670503, KAKENHI-PROJECT-15K10324, KAKENHI-PROJECT-25461553
[Journal Article] Anti-inflammatory effects of noradrenaline on LPS-treated microglial cells: Suppression of NFκB nuclear translocation and subsequent STAT1 phosphorylation.2015
- Author(s)
  Ishii Y, Yamaizumi A, Kawakami A, Islam A, Choudhury ME, Takahashi H, Yano H, Tanaka J
- Journal Title
  
  Neurochem Int.
  
  Volume: 90 Pages: 56-66
- DOI
  10.1016/j.neuint.2015.07.010
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K10324, KAKENHI-PROJECT-15K10809, KAKENHI-PROJECT-15K14351
[Journal Article] The Ameliorative Effects of a Hypnotic Bromvalerylurea in Sepsis2015
- Author(s)
  Kikuchi S, Nishihara T, Kawasaki S, Abe N, Kuwabara J, Choudhury ME, Takahashi H, Yano H, Nagaro T, Watanabe Y, Aibiki M, Tanaka J
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 459 Issue: 2 Pages: 319-326
- DOI
  10.1016/j.bbrc.2015.02.111
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K10324, KAKENHI-PROJECT-15K10809, KAKENHI-PROJECT-15K14351, KAKENHI-PROJECT-15K20343
[Journal Article] Activated microglia in a rat stroke model express NG2 proteoglycan in peri-infarct tissue through the involvement of TGF-β12014
- Author(s)
  Sugimoto K, Nishioka R, Ikeda A, Mise A, Takahashi H, Yano H, Kumon Y, Ohnishi T, Tanaka J
- Journal Title
  
  GLIA
  
  Volume: 62 Pages: 185-198
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592129
[Journal Article] Oct-3/4 promotes tumor angiogenesis through VEGF production in glioblastoma2014
- Author(s)
  Takahashi H, Inoue A,　Kawabe Y, et al.
- Journal Title
  
  Brain Tumor Pathology
  
  Volume: ３２ Issue: 1 Pages: 31-40
- DOI
  10.1007/s10014-014-0203-3
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25861280, KAKENHI-PROJECT-26861150, KAKENHI-PROJECT-15K10324, KAKENHI-PROJECT-15K14351
[Journal Article] Oct-3/4 modulates the drug-resistant phenotype of glioblastoma cells through expression of ATP binding cassette transporter G22014
- Author(s)
  Hosokawa Y, Takahashi H, Inoue A,　et al.
- Journal Title
  
  Biochimica et Biophysica Acta
  
  Volume: １８５０ Issue: 6 Pages: 1197-1205
- DOI
  10.1016/j.bbagen.2015.01.017
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25861280, KAKENHI-PROJECT-26861150, KAKENHI-PROJECT-15K10324, KAKENHI-PROJECT-15K14351
[Journal Article] Expression of MCP-1 and fractalkine on endothelial cells and astrocytes may contribute to the invasion and migration of brain macrophages in ischemic rat brain lesions2013
- Author(s)
  Nari Tei
- Journal Title
  
  J Neurosci Res
  
  Volume: 91 Issue: 5 Pages: 681693-681693
- DOI
  10.1002/jnr.23202
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390037, KAKENHI-PROJECT-22591590, KAKENHI-PROJECT-23592092, KAKENHI-PROJECT-23592129, KAKENHI-PROJECT-23592130, KAKENHI-PROJECT-23659688, KAKENHI-PROJECT-24791507
[Journal Article] Expression of MCP-1 and fractalkine on endothelial cells and astrocytes may contribute to the invasion and migration of brain macrophages in ischemic rat brain lesions2013
- Author(s)
  Nari Tei, Junya Tanaka, Kana Sugimoto, Tasuku Nishihara, Ryutaro Nishioka, Hisaaki Takahashi, Hajime Yano, Shirabe Matsumoto, Shiro Ohue, Hideaki Watanabe, Yoshiaki Kumon, Takanori Ohnishi
- Journal Title
  
  J Neurosci Res
  
  Volume: 91 Pages: 681-693
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659688
[Journal Article] Postnatal interleukin-1βenhances adulthood seizure susceptibility and neuronal cell death after prolonged experimental febrile seizures in infantile rats2013
- Author(s)
  Fukuda M, Hino H, Suzuki Y, Takahashi H, Morimoto T, Ishii E
- Journal Title
  
  Acta Neurologica Belgica
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592129
[Journal Article] Expression of MCP-1 and fractalkine on endothelial cells and astrocytes may contribute to the invasion and migration of brain macrophages in ischemic rat brain lesions2013
- Author(s)
  Nari Tei, Junya Tanaka, Kana Sugimoto, Tasuku Nishihara, Ryutaro Nishioka, Hisaaki Takahashi, Hajime Yano, Shirabe Matsumoto, Shiro Ohue, Hideaki Watanabe, Yoshiaki Kumon, Takanori Ohnishi
- Journal Title
  
  J Neurosci Res
  
  Volume: 91 Pages: 681-693
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390037
[Journal Article] Expression of MCP-1 and fractalkine on endothelial cells and astrocytes may contribute to the invasion and migration of brain macrophages in ischemic rat brain lesions2013
- Author(s)
  Tei N, Tanaka J, Sugimoto K, Nishihara T, Nishioka R, Takahashi H, Yano H, Matsumoto S, Ohue S, Watanabe H, Kumon Y, Ohnishi T
- Journal Title
  
  J Neurosci Res
  
  Volume: 91 Pages: 681-693
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592129
[Journal Article] Anticonvulsive effect of paeoniflorin on experimental febrile seizures in immature rats : possible application for febrile seizures in children2012
- Author(s)
  Hino H, Takahashi H, Suzuki Y, Tanaka J, Ishii E, Fukuda M
- Journal Title
  
  PLoS One
  
  Volume: 7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592129
[Journal Article] Oct-3/4 promotes migration and invasion of glioblastoma cells.2012
- Author(s)
  Kobayashi K, Takahashi H, Inoue A, Harada H, Toshimori S, Kobayashi Y, Goto K, Sugimoto K, Yano H, Ohnishi T, Tanaka J.
- Journal Title
  
  J Cell Biochem
  
  Volume: 113 Pages: 508-517
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390037
[Journal Article] Oct-3/4 promotes migration and invasion of glioblastoma cells2012
- Author(s)
  Kobayashi K
- Journal Title
  
  J Cell Biochem
  
  Volume: 113 Issue: 2 Pages: 508517-508517
- DOI
  10.1002/jcb.23374
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390037, KAKENHI-PROJECT-23592129, KAKENHI-PROJECT-23592130, KAKENHI-PROJECT-23659688
[Journal Article] Oct-3/4 promotes migration and invasion of glioblastoma cells2012
- Author(s)
  Kobayashi K, Takahashi H, Inoue A, Harada H, Toshimori S, Kobayashi Y, Goto K, Sugimoto K, Yano H, Ohnishi T, Tanaka J
- Journal Title
  
  J Cell Biochem
  
  Volume: 113 Pages: 508-517
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659688
[Journal Article] Oct-3/4 promotes migration and invasion of glioblastoma cells2012
- Author(s)
  Kobayashi K, Takahashi H, Inoue A, Harada H, Toshimori S, Kobayashi Y, Goto K, Sugimoto K, Yano H, Ohnishi T, Tanaka J
- Journal Title
  
  J Cell Biochem
  
  Volume: 113(2) Pages: 508-517
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592129
[Journal Article] Oct-3/4 promotes migration and invasion of glioblastoma cells.2012
- Author(s)
  Kobayashi K, Takahashi H, Inoue A, Harada H, Toshimori S, Kobayashi Y, Goto K, Sugimoto K, Yano H, Ohnishi T, Tanaka J.
- Journal Title
  
  J Cell Biochem.
  
  Volume: 113 (2) Pages: 508-517
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592129
[Journal Article] Anticonvulsive effect of paeoniflorin on experimental febrile seizures in immature rats: possible application for febrile seizures in children2012
- Author(s)
  Hitomi Hino, Hisaaki Takahashi, Yuka Suzuki, Junya Tanaka, Eiichi Ishii, Mitsumasa Fukuda
- Journal Title
  
  PLoS ONE
  
  Volume: 7 Issue: 8 Pages: e42920-e42920
- DOI
  10.1371/journal.pone.0042920
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390037, KAKENHI-PROJECT-22591132, KAKENHI-PROJECT-23592129, KAKENHI-PROJECT-23659688
[Journal Article] Subcutaneous injection containing IL-3 and GM-CSF amelioratesstab wound-induced brain injury in rats2011
- Author(s)
  Nishihara T, Michihisa Ochi M, Kana Sugimoto K, Takahashi H, Yano H, Kumon Y, Ohnishi T, Tanaka J
- Journal Title
  
  Experimental Neurology
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390037
[Journal Article] Transient ischemia-induced paresis and complete paraplegia displayed distinct reactions of microglia and macrophages2011
- Author(s)
  NakataT, Kawachi K, Nagashima M, Yasugi T, Izutani H, Ryugo M, Okamura T, Shikata F, Imagawa H, Yano H, Takahashi H, Tanaka J
- Journal Title
  
  Brain Res
  
  Volume: 1420 Pages: 114-124
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659688
[Journal Article] Subcutaneous injection containing IL-3 and GM-CSF ameliorates stab wound-induced brain injury in rats. Tasuku2011
- Author(s)
  Hisaaki Takahashi, Hajime Yano, Yoshiaki Kumon, Takanori Ohnishi, Junya Tanaka.
- Journal Title
  
  Exp Neurol
  
  Volume: 229 Pages: 507-516
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390037
[Journal Article] Transient ischemia-induced paresis and complete paraplegia displayed distinct reactions of microglia and macrophages.2011
- Author(s)
  NakataT, Kawachi K, Nagashima M, Yasugi T, Izutani H, Ryugo M, Okamura T, Shikata F, Imagawa H, Yano H, Takahashi H, Tanaka J.
- Journal Title
  
  Brain Res
  
  Volume: 1420 Pages: 114-124
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390037
[Journal Article] Transient ischemia-induced paresis and complete paraplegia displayed distinct reactions of microglia and macrophages.2011
- Author(s)
  Nakata T, Kawachi K, Nagashima M, Yasugi T, Izutani H, Ryugo M, Okamura T, Shikata F, Imagawa H, Yano H, Takahashi H, Tanaka J.
- Journal Title
  
  Brain Res.
  
  Volume: 1420 Pages: 114-124
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592129
[Journal Article] Subcutaneous injection containing IL-3 and GM-CSF ameliorates stab wound-induced brain injury in rats2011
- Author(s)
  Nishihara, Michihisa Ochi, Kana Sugimoto, Hisaaki Takahashi, Hajime Yano, Yoshiaki Kumon, Takanori Ohnishi, Junya Tanaka
- Journal Title
  
  Exp Neurol
  
  Volume: 229 Pages: 507-516
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659688
[Journal Article] Subcutaneous injection containing IL-3 and GM-CSF ameliorates stab wound-induced brain injury in rats.2011
- Author(s)
  Nishihara T, Ochi M, Sugimoto K, Takahashi H, Yano H, Kumon Y, Ohnishi T, Tanaka J.
- Journal Title
  
  Exp Neurol.
  
  Volume: 229 (2) Pages: 507-516
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592129
[Journal Article] A cytokine mixture of GM‐CSF and IL‐3 that induces a neuroprotective phenotype of microglia leading to amelioration of (6‐OHDA)‐induced Parkinsonism of rats2011
- Author(s)
  Choudhury ME, Sugimoto K, Kubo M, Nagai M, Nomoto M, Takahashi H, Yano H, Tanaka J.
- Journal Title
  
  Brain Behav
  
  Volume: 1 Pages: 26-43
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390037
[Journal Article] A cytokine mixture of GM‐CSF and IL‐3 that induces a neuroprotective phenotype of microglia leading to amelioration of (6‐OHDA)‐induced Parkinsonism of rats2011
- Author(s)
  Choudhury ME, Sugimoto K, Kubo M, Nagai M, Nomoto M, Takahashi H, Yano H, Tanaka J
- Journal Title
  
  Brain Behav
  
  Volume: 1 Pages: 26-43
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659688
[Journal Article] A cytokine mixture of GM-CSF and IL-3 that induces a neuroprotective phenotype of microglia leading to amelioration of (6-OHDA)-induced Parkinsonism of rats.2011
- Author(s)
  Choudhury ME, Sugimoto K, Kubo M, Nagai M, Nomoto M, Takahashi H, Yano H, Tanaka J.
- Journal Title
  
  Brain Behav.
  
  Volume: 1 (1) Pages: 26-43
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592129
[Journal Article] Iba1(+)/NG2(+) macrophage-like cells expressing a variety of neuroprotective factors ameliorate ischemic damage of the brain.2010
- Author(s)
  A.Smirkin, H.Matsumoto, H.Takahashi, A.Inoue, M.Tagawa, S.Ohue, H.Watanabe, H.Yano, Y.Kumon T.Ohnishi, J.Tanaka.
- Journal Title
  
  J Cereb Blood Flow Metab.
  
  Volume: 30 Pages: 603-615
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21791366
[Journal Article] Iba1(+)/NG2(+) macrophage-like cells expressing a variety of neuroprotective factors ameliorate ischemic damage of the brain2010
- Author(s)
  Smirkin, A.Matsumoto, H.Takahashi, H.Inoue, A.Tagawa, M.Ohue, S.Watanabe, H.Yano, H.Kumon, Y.Ohnishi, T.Tanaka, J.
- Journal Title
  
  Journal of Cerebral Blood Flow and Metabolism
  
  Volume: 30 Pages: 603-615
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390037
[Journal Article] Iba1+/NG2+ macrophage-like cells expressing a variety of neuroprotective factors ameliorate ischemic damage of the brain.2010
- Author(s)
  Anna Smirkin, Hiroaki Matsumoto, Hisaaki Takahashi, Akihiro Inoue, Masahiko Tagawa, Shiro Ohue, Hideaki Watanabe, Hajime Yano, Yoshiaki Kumon, Takanori Ohnishi and Junya TanakaJ
- Journal Title
  
  J Cereb Blood Flow Metab
  
  Volume: 30 Pages: 603-615
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390037
[Journal Article] APP/PS1 double mutant mouse and in Alzheimer's disease.2010
- Author(s)
  H.Takahashi, I.Brasnjevic, B.P.Rutten, N.Van Der Kolk, D.P.Perl, C.Bouras, H.W.Steinbusch, C.Schmitz, P.R.Hof, D.L.Dickstein.
- Journal Title
  
  Brain Struct.Funct.
  
  Volume: 214 Pages: 145-160
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21791366
[Journal Article] Cancer stem-like cells of glioblastoma characteristically express MMP-13 and display highly invasive activity2010
- Author(s)
  Inoue A., Takahashi, H., Harada, H., Kohno, S., Ohue, S., Kobayashi, K., Yano, H., Tanaka, J., Ohnishi, T.
- Journal Title
  
  International journal of oncology
  
  Volume: 37 Pages: 1121-1131
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390037
[Journal Article] Cancer stem-like cells of glioblastoma characteristically express MMP-13 and display highly invasive activity.2010
- Author(s)
  A.Inoue, H.Takahashi, H.Harada, S.Kohno, S.Ohue, K.Kobayashi, H.Yano, J.Tanaka, T.Ohnishi.
- Journal Title
  
  International J.Oncology 37
  
  Pages: 1121-1131
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21791366
[Journal Article] Cancer stem-like cells of glioblastoma characteristically express MMP-13 and display highly invasive activity.2010
- Author(s)
  Inoue, A., Takahashi, H., Harada, H., Kohno, S., Ohue, S., Kobayashi, K., Yano, H., Tanaka, J., Ohnishi, T.
- Journal Title
  
  Int J Oncol
  
  Volume: 37 Pages: 1121-1131
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390037
[Journal Article] Cancer stem-like cells of glioblastoma characteristically express MMP-13 and display highly invasive activity.2010
- Author(s)
  A.Inoue, H.Takahashi, H.Harada, S.Kohno, S.Ohue, K.Kobayashi, H.Yano, J.Tanaka, T.Ohnishi.
- Journal Title
  
  International J.Oncology
  
  Volume: 37 Pages: 1121-1131
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21791366
[Journal Article] Hippocampal interneuron loss in an APP/PS1 double mutant mouse and in Alzheimer's disease2010
- Author(s)
  Takahashi H, et al
- Journal Title
  
  Brain Structure Function 214
  
  Pages: 145-160
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21791366
[Journal Article] Iba1(+)/NG2(+) macrophage-like cells expressing a variety of neuroprotective factors ameliorate ischemic damage of the brain.2010
- Author(s)
  A.Smirkin, H.Matsumoto, H.Takahashi, A.Inoue, M.Tagawa, S.Ohue, H.Watanabe, H.Yano, Y.Kumon, T.Ohnishi, J.Tanaka.
- Journal Title
  
  J Cereb Blood Flow Metab. 30
  
  Pages: 603-615
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21791366
[Journal Article] Accumulation of maoophage-like cells expressing NG2 proteoglycan and Ilbal in ischemic core of rat brain after transient middle cerebral artery ocdusion.2008
- Author(s)
  H. Matsumoto, Y. Kumon, H. Watanabe, T. Ohnishi, M. Shukou, M. Chuai, Y. Imai, H. Takahashi, and J. Tanaka
- Journal Title
  
  J. Cereb. Blood Flow Metab. 28
  
  Pages: 149-163
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18791021
[Journal Article] Involvement of Heparanase in Migration of Miaogfal Cells.2008
- Author(s)
  H.Takahashi, H. Matsumoto, A. Smirkin, T. Itai, Y. Nishimura and J. Tanaka
- Journal Title
  
  Biochim. Biophys. Acta 1780
  
  Pages: 709-715
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18791021
[Journal Article] Expression of CD200 by macrophage-like cells in ischemic core of rat brain after transient middle cerebral artery occlusion2007
- Author(s)
  H Matsumoto, Y Kumon, H Watanabe, T Ohnishi, H Takahashi, Y Imai, J Tanaka
- Journal Title
  
  Neuroscience Letters (In press)
- Data Source
  KAKENHI-PROJECT-17659448
[Journal Article] Antibodies to CD11b, CD68, and lectin label neutrophils rather than microglia in traumatic and ischemic brain lesions2007
- Author(s)
  H Matsumoto, Y Kumon, H Watanabe, T Ohnishi, M Shudou, C Ii, H Takahashi, Y Imai, J Tanaka
- Journal Title
  
  Journal of Neuroscience Research 85
  
  Pages: 994-1029
- Data Source
  KAKENHI-PROJECT-17659448
[Journal Article] Expression of heparanase in nestin-positive reactive astrocytes in ischemic lesions of rat brain after transient middle cerebral artery occlusion2007
- Author(s)
  H Takahashi, H Matsumoto, Y Kumon, T Ohnishi, C Freeman, Y Imai, J Tanaka
- Journal Title
  
  Neuroscience Letters (In press)
- Data Source
  KAKENHI-PROJECT-17659448
[Journal Article] Expression of CD200 by macrophage-like cells in ischemic core of rat brain after transient middle cerebral artery occlusion2007
- Author(s)
  H.Matsumoto, Y.Kumon, H.Watanabe, T.Ohnishi, H.Takahashi, Y.Imai, J.Tanaka
- Journal Title
  
  Neuroscience Letters (In press)
- Data Source
  KAKENHI-PROJECT-18791021
[Journal Article] Antibodies to CD11b, CD68, and lectin label neutrophils rather than microglia in traumatic and ischemic brain lesions.2007
- Author(s)
  H.Matsumoto, Y.Kumona, H.Watanabe, T.Ohnishi, M.Shudou, C.Ii, H.Takahashi, Y.Imai, J.Tanaka
- Journal Title
  
  Journal of Neuroscience Research 85・5
  
  Pages: 994-994
- Data Source
  KAKENHI-PROJECT-18791021
[Journal Article] Expression of CD200 by macophage-like cells in ischemic core of rat brain after transient middle cerebral artery ocdusion.2007
- Author(s)
  H. Matsumoto, Y. Kumon, H. Watanabe, T. Ohnishi, M. Shukou, M. Chuai, Y. Imai, H. Takahashi, and J. Tanaka
- Journal Title
  
  Neuroscience Letters 418
  
  Pages: 44-48
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18791021
[Journal Article] Antibokies to CD11b, CD68, and lectin label neutrophils rather than micoglia in traumatic and ischemic brain lesions.2007
- Author(s)
  H. Matsumoto, Y. Kumon, H. Watanabe, T. Ohnishi, S. Masachika, C. Ii, H. Takahashi, Y. Imai and J. Tanaka
- Journal Title
  
  J. Neurosci. Res. 85
  
  Pages: 994-1009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18791021
[Journal Article] Expression of heparanase in nestin-positive reactive astrocytes in ischemic lesions of rat brain after transient middle cerebral artery ocdusion.2007
- Author(s)
  H.Takahashi, H. Matsumoto. Y. Kumon, T. Ohnishi, C. Freeman, Y. Imai and J. Tanaka
- Journal Title
  
  Neuroscience Letters 417
  
  Pages: 250-254
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18791021
[Journal Article] Expression of heparanase in nestin-positive reactive astrocytes in ischemic lesions of rat brain after transient middle cerebral artery occlusion.2007
- Author(s)
  H.Takahashi, H.Matsumoto, Y.Kumon, T.Ohnishi, C.Freeman, Y.Imai, J.Tanaka
- Journal Title
  
  Neuroscience Letters (In press)
- Data Source
  KAKENHI-PROJECT-18791021
[Journal Article] Molecular cloning and characterization of Nop25, a novel nucleolar RNA binding protein, highly conserved in vertebrate species.2006
- Author(s)
  S.Suzuki, M.Kanno, T.Fujiwara, H.Sugiyama, A.Yokoyama, H.Takahashi, J.Tanaka
- Journal Title
  
  Experimental Cell Research 312・7
  
  Pages: 1031-1031
- Data Source
  KAKENHI-PROJECT-18791021
[Journal Article] Mapping a nucleolar targeting sequence of an RNA binding nucleolar protein, Nop252006
- Author(s)
  Fujiwara, T., Suzuki, S., Kanno, M., Sugiyama, H., Takahashi, H., Tanaka.J.
- Journal Title
  
  Experimental Cell Research 312
  
  Pages: 1703-1712
- Data Source
  KAKENHI-PROJECT-17659448
[Journal Article] Mapping a nucleolar targeting sequence of an RNA binding nucleolar protein, Nop25.2006
- Author(s)
  T.Fujiwara, S.Suzuki, M.Kanno, H.Sugiyama, H.Takahashi, J.Tanaka
- Journal Title
  
  Experimental Cell Research 312・10
  
  Pages: 1703-1703
- Data Source
  KAKENHI-PROJECT-18791021
[Journal Article] Molecular cloning and characterization of Nop25, a novel nucleolar RNA binding protein, highly conserved in vertebrate species2006
- Author(s)
  Suzuki, S., Kanno, M., Fujiwara, T., Sugiyama, H., Yokoyama, A., Takahashi, H., Tanaka, J.
- Journal Title
  
  Experimental Cell Research 312
  
  Pages: 1031-1041
- Data Source
  KAKENHI-PROJECT-17659448
[Journal Article] Regulation of ADF/cofilin phosphorylation and synaptic function by LIM-kinase.2004
- Author(s)
  Y.Meng, H.Takahashi, J.Meng, Y.Zhaing, G.Lu, A.Asrar, T.Nakamura, Z.Jia
- Journal Title
  
  Neuropharmacology 47
  
  Pages: 746-754
- Data Source
  KAKENHI-PROJECT-15659356
[Journal Article] Regulation of ADF/cofilin phosphorylation and synaptic function by LIM-kinase.2004
- Author(s)
  Y.Meng, H.Takahashi, J.Meng, Y Zhang, G.Lu, A.Asrar, T.Nakamura, Z.Jia
- Journal Title
  
  Neuropharmacology 47
  
  Pages: 746-754
- Data Source
  KAKENHI-PROJECT-16390442
[Journal Article] Regulation of ADF/cofilin phosphorylation and synaptic function by LIM-kinase.2004
- Author(s)
  Y.Meng, H.Takahashi, J.Meng, Y Zhang, G.Lu, A.Asrar, T.Nakamura
- Journal Title
  
  Neuropharmacology 47
  
  Pages: 746-754
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390442
[Journal Article] Regulation of ADF/cofilin phosphorylation and synaptic function by LIM-kinase.2004
- Author(s)
  Y.Meng, H.Takahashi, J.Meng, Y Zhang, G.Lu, A.Asrar, T.Nakamura, Z.Jia
- Journal Title
  
  Neuropharmacology 47・5
  
  Pages: 746-754
- Data Source
  KAKENHI-PROJECT-16790822
[Presentation] Oct-3/4を介したMGMT遺伝子発現調節とDNMT1の関連性2017
- Author(s)
  井上明宏、高野昌平、大上史朗、高橋寿明、田中潤也、大西丘倫、國枝武治
- Organizer
  第35回　日本脳腫瘍病理学会
- Data Source
  KAKENHI-PROJECT-15K10324
[Presentation] 膠芽腫におけるOct-3/4を介したMGMT遺伝子発現調節とDNMT1の関連性2017
- Author(s)
  井上明宏、高野昌平、西川真弘、末廣諭、高橋寿明、田中潤也、國枝武治
- Organizer
  日本脳神経外科学会第76回学術総会
- Data Source
  KAKENHI-PROJECT-15K10324
[Presentation] 膠芽腫におけるMGMT発現調節機構に対するOct-3/4を介したエピジェネティクスの制御2016
- Author(s)
  井上明宏、大上史朗、岩田真治、河野兼久、高野昌平、大西丘倫、高橋寿明、田中潤也
- Organizer
  日本脳神経外科学会第75回学術総会
- Place of Presentation
  福岡
- Year and Date
  2016-09-29
- Data Source
  KAKENHI-PROJECT-15K10324
[Presentation] Oct-3/4のMGMT発現調節機構への関与2016
- Author(s)
  井上明宏、高野昌平、大上史朗、大西丘倫、高橋寿明、田中潤也
- Organizer
  第34回日本脳腫瘍病理学会
- Place of Presentation
  東京
- Year and Date
  2016-05-27
- Data Source
  KAKENHI-PROJECT-15K10324
[Presentation] 腫瘍幹細胞の病態生理学：腫瘍制御の技術基盤を目指して2015
- Author(s)
  高橋寿明
- Organizer
  日本病態生理学会
- Place of Presentation
  愛媛
- Year and Date
  2015-07-31
- Invited
- Data Source
  KAKENHI-PROJECT-15K10324
[Presentation] Oct-3/4 promotes tumor angiogenesis in glioblastoma through VEGF production2014
- Author(s)
  Hisaaki Takahashi, Yuya Kawabe, Shinji Iwata, Kana Sugimoto, Hajime Yano, Junya Tanaka
- Organizer
  第91回日本生理学会
- Place of Presentation
  鹿児島
- Data Source
  KAKENHI-PROJECT-23592129
[Presentation] Oct-3/4 promotes tumor angiogenesis in glioblastoma through VEGF production2014
- Author(s)
  Takahashi H, Kawabe Y, Iwata S, Sugimoto K, Yano H, Tanaka J
- Organizer
  日本生理学会
- Place of Presentation
  鹿児島
- Data Source
  KAKENHI-PROJECT-23592129
[Presentation] Response of glial cells in and around ischemic lesion of rats that were subjected to transient middle cerebral artery occlusion: the involvement of IL-18 Ayano Mise2013
- Author(s)
  Kana Sugimoto, Ryutaro Nishioka, Hisaaki Takahashi, Hajime Yano, Junya Tanak
- Organizer
  第90回日本生理学会大会
- Place of Presentation
  東京都
- Data Source
  KAKENHI-PROJECT-22390037
[Presentation] Oct-3/4 induces CpG demethylation in the MGMT promoter to induce temozolomide resistance in glioblastoma cells2013
- Author(s)
  Hisaaki Takahashi, Yukako Kobayashi, Kana Sugimoto, Hajime Yano, Junya Tanaka
- Organizer
  第90回　日本生理学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23592129
[Presentation] Invasion of monocytes/macrophages into ischemic lesion of rat brain: involvement of chemokines and their receptors2013
- Author(s)
  Yudai Ohara, Kana Sugimoto, Ryutaro Nishioka, Hisaaki Takahashi, Hajime Yano、Nari Tei, Yoshiaki Kumon, Takanori Ohnishi, Junya Tanaka
- Organizer
  第90回日本生理学会大会
- Place of Presentation
  東京都
- Data Source
  KAKENHI-PROJECT-22390037
[Presentation] Invasion of monocytes/macrophages into ischemic lesion of rat brain: involvement of chemokines and their receptors2013
- Author(s)
  Yudai Ohara, Kana Sugimoto, Ryutaro Nishioka, Hisaaki Takahashi, Hajime Yano、Nari Tei, Yoshiaki Kumon, Takanori Ohnishi, Junya Tanaka
- Organizer
  第90回日本生理学会大会
- Place of Presentation
  東京都
- Data Source
  KAKENHI-PROJECT-23659688
[Presentation] Response of glial cells in and around ischemic lesion of rats that were subjected to transient middle cerebral artery occlusion: the involvement of IL-182013
- Author(s)
  Ayano Mise, Kana Sugimoto, Ryutaro Nishioka, Hisaaki Takahashi, Hajime Yano, Junya Tanaka
- Organizer
  第90回日本生理学会大会
- Place of Presentation
  東京都
- Data Source
  KAKENHI-PROJECT-23659688
[Presentation] Oct-3/4 induces CpG demethylation in MGMT promoter to acquire temozolomide resistance in glioblastoma cells2013
- Author(s)
  Takahashi H, Inoue A, Kobayashi Y, Hosokawa Y, Harada H, Ohnishi T, Sugimoto K, Yano H, Tanaka J
- Organizer
  日本生理学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23592129
[Presentation] Oct-3/4 promotes migration and invasion of glioblastoma cells2012
- Author(s)
  Takahashi H, Kobayashi K, Inoue A, Harada H, Sugimoto K, Yano H, Ohnishi T, Tanaka J
- Organizer
  日本生理学会
- Place of Presentation
  松本
- Data Source
  KAKENHI-PROJECT-23592129
[Presentation] A cytokine mixture containing GM-CSF and IL-3 targeting microglia ameliorates neurological deficits of Parkinson's disease model rats2012
- Author(s)
  Junya Tanaka, Mohammed E. Choudhury, Kana Sugimoto, Hisaaki Takahashi, Hajime Yano
- Organizer
  第89回日本生理学会大会
- Place of Presentation
  松本市
- Data Source
  KAKENHI-PROJECT-22390037
[Presentation] 脳梗塞巣に集積するマクロファージの役割とその治療的利用2012
- Author(s)
  田中潤也、杉本香奈、西原佑、高橋寿明、矢野元
- Organizer
  第22回日本病態生理学会
- Place of Presentation
  大分県由布市
- Data Source
  KAKENHI-PROJECT-23659688
[Presentation] 脳梗塞巣に集積するマクロファージの役割とその治療的利用2012
- Author(s)
  田中潤也、杉本香奈、西原佑、高橋寿明、矢野元
- Organizer
  第22回日本病態生理学会
- Place of Presentation
  大分県由布市
- Data Source
  KAKENHI-PROJECT-22390037
[Presentation] A cytokine mixture containing GM-CSF and IL-3 targeting microglia ameliorates neurological deficits of Parkinson's disease model rats2012
- Author(s)
  Junya Tanaka, Mohammed E. Choudhury, Kana Sugimoto, Hisaaki Takahashi, Hajime Yano
- Organizer
  第89回日本生理学会大会
- Place of Presentation
  大分県由布市
- Data Source
  KAKENHI-PROJECT-23659688
[Presentation] Oct-3/4 promotes migration and invasion of glioblastoma cells2012
- Author(s)
  Hisaaki Takahashi, Kana Kobayashi, Akihiro Inoue, Hironobu Harada, Kana Sugimoto, Hajime Yano, Takanori Ohnishi, Junya Tanaka
- Organizer
  第89回　日本生理学会大会
- Place of Presentation
  長野・松本
- Data Source
  KAKENHI-PROJECT-23592129
[Presentation] 膠芽腫における腫瘍幹細胞の性状解析と浸潤能の検討2010
- Author(s)
  高橋寿明
- Organizer
  Neuro2010 日本神経科学大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-21791366
[Presentation] Generation of ramified microglia and other types of neural cells from leptomeninges2010
- Author(s)
  Kana Sugimoto, Hisaaki Takahashi, Hajime Yano, Junya Tanaka
- Organizer
  Neuro2010
- Place of Presentation
  神戸
- Year and Date
  2010-09-02
- Data Source
  KAKENHI-PROJECT-22390037
[Presentation] Disruption of LIM-Kinase 2 modulates hippocampal neurodege neration by requlating ER-calcium release2009
- Author(s)
  Takahashi H, et al
- Organizer
  36th Congress of the International Union of Physiological Science
- Place of Presentation
  Kyoto (Japan)
- Year and Date
  2009-07-29
- Data Source
  KAKENHI-PROJECT-21791366
[Presentation] Spheres isolated from human glioblastoma promote tumor progression and possess cancer stem cell-like phenotype2009
- Author(s)
  H.Takahashi
- Organizer
  9th European meeting of Glial cells
- Place of Presentation
  フランス(パリ)
- Data Source
  KAKENHI-PROJECT-21791366
[Presentation] Spheres isolated from human glioblastoma promote tumor progression and possess cancer stem cell-like phenotype.2009
- Author(s)
  H.Takahashi, A.Inoue, H.Harada, T.Ohnishi, J.Tanaka
- Organizer
  9th European meeting of Glial cells
- Place of Presentation
  フランス(パリ)
- Data Source
  KAKENHI-PROJECT-21791366
[Presentation] Spheres isolated from human glioblastoma promote tumor progression and possess cancer stem cell-like phenotype2009
- Author(s)
  Takahashi H, et al
- Organizer
  9th European meeting of Glial cells
- Place of Presentation
  Paris (France)
- Year and Date
  2009-09-10
- Data Source
  KAKENHI-PROJECT-21791366
[Presentation] ラット中大脳動脈一時閉塞モデルにおけるヘパラナーゼの発現2007
- Author(s)
  高橋寿明, 松本洋明, Anna Smirkin, 田中潤也
- Organizer
  日本神経科学会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-18791021
[Presentation] 虚血中心部へ浸潤・集積するマイクログリア/マクロファージ系細胞および反応性アストロサイトにおけるヘパラナーゼの機能的関与2007
- Author(s)
  高橋寿明, 田中潤也
- Organizer
  ORIGIN神経科学研究会
- Place of Presentation
  浜松
- Data Source
  KAKENHI-PROJECT-18791021
[Presentation] 脳梗塞およびマイクログリア・マクロファージ系細胞におけるヘパラナーゼ役割2007
- Author(s)
  高橋寿明, 松本洋明, Anna Smirkin, 田中潤也
- Organizer
  ダリア研究会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-18791021

1. TANAKA Junya (70217040)

# of Collaborated Projects: 6 results

# of Collaborated Products: 40 results
2. IMAI Yoshinori (20270689)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
3. SUZUKI Shunji (60372728)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
4. YANO Hajime (00284414)

# of Collaborated Projects: 2 results

# of Collaborated Products: 26 results
5. SUGIMOTO Kana (00581034)

# of Collaborated Projects: 2 results

# of Collaborated Products: 17 results
6. OHNISHI Takanori (70233210)

# of Collaborated Projects: 2 results

# of Collaborated Products: 13 results
7. KUMON Yoshiaki (80127894)

# of Collaborated Projects: 2 results

# of Collaborated Products: 10 results
8. 竹内文也 (30281835)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. 井上明宏 (20593403)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
10. YAMAMOTO Haruyasu (10092446)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. OGATA Tadanori (30291503)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 北間正崇 (50285516)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 鎌田恭輔 (80372374)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. WATANABE Hideaki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. KUNIEDA Takeharu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 石井榮一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 西川真弘

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

TAKAHASHI Hisaaki 高橋 寿明

Takahashi Hisaaki 高橋 寿明

高橋 寿明 タカハシ ヒサアキ

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腫瘍血管を特異的に破壊する悪性グリオーマ新規抗体治療薬の開発Principal Investigator

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Development of molecular-targeted therapeutic drugs for malignant glioma that enable reactivation of tumor immunityPrincipal Investigator

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微弱蛍光の可視化と数値情報の提示によって脳腫瘍切除手術を支援するシステムの構築

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Development of Oct-3/4 targeting drug for malignant glioma treatmentPrincipal Investigator

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Oct-3/4 promotes tumor angiogenesis through VEGF production in glioblastomaPrincipal Investigator

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Determination of cell type(s) that should be transplanted into lesion core of the brain for better outcome

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Multipotential stem cell-like nature of bone marrow-derived macrophages accumulated in lesion core of acute and severe brain injuries.

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Involvement of cancer stem cells in the failure of curative treatmentPrincipal Investigator

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Cre-Loxpシステムを用いたマイクログリアの細胞系譜解析と脳腫瘍研究への応用Principal Investigator

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トランスジェニックマウスを用いたマイクログリアによる脳損傷修復システムの解明

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脳傷害部位へ遊走するマイクログリアの細胞内分子メカニズムの解明Principal Investigator

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Development of novel therapeutic means to regenerating spinal cord injury using microglia/macrophages

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革命的脊髄損傷治療法の開発:骨髄細胞あるいは末梢血から中枢神経組織を作る

Principal Investigator

TAKAHASHI Hisaaki 高橋寿明

Takahashi Hisaaki 高橋寿明

高橋寿明タカハシヒサアキ