TAKAHASHI NOBUHIKO 高橋伸彦

… Alternative Names

TAKAHASHI Nobuhiko 高橋伸彦

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Researcher Number	20372279
Other IDs	https://orcid.org/0000-0003-2028-5405
Affiliation (Current)	2025: 北海道医療大学, 歯学部, 教授
Affiliation (based on the past Project Information) *help	2020 – 2023: 北海道医療大学, 歯学部, 教授 2010 – 2019: 北海道医療大学, 歯学部, 准教授 2013: 北海道医療大学, 歯学部内科学分野, 准教授 2010: Asahikawa Medical College, 歯学部, 准教授 2009: Asahikawa Medical College, 医学部, 客員講師 … More 2007 – 2009: Asahikawa Medical College, Department of General Medicine, Assistant Professor 2007: Asahikawa Medical College, 総合診療部, 助教 2005 – 2006: 旭川医科大学, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator Metabolomics / Basic Section 52010:General internal medicine-related / Laboratory medicine Except Principal Investigator Gastroenterology / Laboratory medicine / Basic Section 52010:General internal medicine-related
Keywords	Principal Investigator 糖代謝異常 / 病態マーカー / 脂肪細胞 / 蛋白質 / タンパク質 / ミトコンドリア / インスリン抵抗性 / 分泌小胞 / 体液診断 / 分泌タンパク質 … More / 病理学 / 核酸 / エクソソーム / 骨格筋細胞 / 臓器特異的病態マーカー / 長鎖非コードRNA / 非コードRNA / 糖尿病 / 第VII因子 / 第VII因子活性化プロテアーゼ / 肥満症 / Lipin / メタボリックシンドローム / ユビキチン・プロテアソーム / インスリン受容体基質 / 代謝異常学 / 脂質代謝 / 糖代謝 … More Except Principal Investigator 血栓マーカー / 希釈プロトロンビン時間 / 直接経口抗凝固薬 / 血栓塞栓症 / claudin / E-cadherin / troglitazone / 血栓症 / 中枢神経 / マイクロアレイ / 迷走神経 / 出血イベント / 確認検査 / Xa阻害薬 / 出血マーカー / 残存抗凝固能 / 出血リスク / 血栓リスク / 確認試験 / 直接Xa阻害薬 / ダビガトラン / エカリン / 直接経口Xa阻害薬 / 新規経口抗凝固薬 / 抗凝固療法 / Pancreas cancer / MEK-ERK signal / cell invasion / PPARgamma / 抗腫瘍作用 / 細胞浸潤 / MEK-ERKシグナル / 膵臓癌 / PPARγ / ループスアントコアグラント / 抗リン脂質抗体症候群 / 交差混合試験 / 抗リン脂質抗体 / ループスアンチコアグラント / 臓器間相互作用 / 脂質代謝 / 糖質代謝 / 小腸モデル / LPS / マウス / TRPV / 脂肪肝 / シグナル伝達 / vanin-1 / 肝脂肪 / 細胞増殖 / TRH / 糖代謝 / hekisokinase / 遺伝子発現 / 肝臓 Less

An exploratory study of extracellular mitochondrial proteins as novel markers of insulin resistance.Principal Investigator
- Principal Investigator
  
  高橋伸彦
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  Health Sciences University of Hokkaido
An exploratory study of extracellular proteins as novel markers of organ-specific glucose dysmetabolism.Principal Investigator
- Principal Investigator
  
  TAKAHASHI Nobuhiko
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  Health Sciences University of Hokkaido
Research on the development of an index for bleeding and thrombosis risk during direct oral anticoagulant treatment
- Principal Investigator
  
  Ohmura Kazumasa
- Project Period (FY)
  2018 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  Health Sciences University of Hokkaido
The investigation of long noncoding RNA in exosome as a marker for glucometabolism in organPrincipal Investigator
- Principal Investigator
  
  Takahashi Nobuhiko
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Health Sciences University of Hokkaido
Development of monitoring tests for residual coagulation activity in novel oral anticoagulants
- Principal Investigator
  
  Ieko Masahiro
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Health Sciences University of Hokkaido
The role of factor seven activating protease in the pathogenesis of obesity-related disorders, and its potential applications as a clinical biomarkerPrincipal Investigator
- Principal Investigator
  
  TAKAHASHI Nobuhiko
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Health Sciences University of Hokkaido
Standardization of the measuring method for lupus anticoagulant (LA)
- Principal Investigator
  
  IEKO Masahiro
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Health Sciences University of Hokkaido
糖・脂質代謝研究に有用なin vitro小腸モデルの構築と臓器間相互作用の解析
- Principal Investigator
  
  YOSHIZAKI Takayuki
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Gastroenterology
- Research Institution
  Kagoshima University
Regulatory mechanisms of lipin, a multifunctional metabolic regulator, and its therapeutic application for metabolic diseasesPrincipal Investigator
- Principal Investigator
  
  TAKAHASHI Nobuhiko
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Metabolomics
- Research Institution
  Asahikawa Medical College
中枢性迷走神経刺激による肝臓で発現する遺伝子発現変化の網羅的解析
- Principal Investigator
  
  OKUMURA Toshikatsu
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Gastroenterology
- Research Institution
  Asahikawa Medical College
肝脂肪過剰蓄積を中枢へ伝達する迷走神経求心路刺激調節機構の解明と治療への応用
- Principal Investigator
  
  大平賀子
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Gastroenterology
- Research Institution
  Asahikawa Medical College
Regulation of insulin receptor substrate through ubiquitin-proteasome pathwayPrincipal Investigator
- Principal Investigator
  
  TAKAHASHI Nobuhiko
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Metabolomics
- Research Institution
  Asahikawa Medical College
Molecular mechanism of the PPARγ ligand-induced growth arrest in GI cancers
- Principal Investigator
  
  OKUMURA Toshikatsu
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Asahikawa Medical College
ジアシルグリセロールキーナゼの糖・脂質代謝調節における役割Principal Investigator
- Principal Investigator
  
  高橋伸彦
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Metabolomics
- Research Institution
  Asahikawa Medical College

[Book] 分子消化器病2009
- Author(s)
  高橋伸彦、他
- Publisher
  先端医学社
- Data Source
  KAKENHI-PROJECT-21790857
[Journal Article] Considerations for simultaneous detection of autoantibodies to coagulation factor and lupus anticoagulant2023
- Author(s)
  Ieko Masahiro，Ohmura Kazumasa，Naito Sumiyoshi，Yoshida Mika，Sasaki Hisaomi，Sato Tsuyoshi，Sugawara Norifumi，Takahashi Nobuhiko，Ichinose Akitada
- Journal Title
  
  Exploration of Immunology
  
  Volume: 3 Pages: 286-299
- DOI
  10.37349/ei.2023.00103
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07403
[Journal Article] Characterization of fibrin/fibrinogen degradation products reagents and their utility in critical care patients with enhanced fibrinolysis2021
- Author(s)
  Kumano Osamu、Ieko Masahiro、Komiyama Yutaka、Naito Sumiyoshi、Yoshida Mika、Takahashi Nobuhiko、Ohmura Kazumasa、Hayakawa Mineji
- Journal Title
  
  International Journal of Laboratory Hematology
  
  Volume: 43 Issue: 4 Pages: 813-820
- DOI
  10.1111/ijlh.13428
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07871
[Journal Article] Measurement of coagulation factor antibody levels is useful for diagnosis and determining therapeutic efficacy in hemorrhagic patients with autoantibodies to coagulation factor VIII and factor V: results from a single center in Japan2021
- Author(s)
  Ieko Masahiro、Ohmura Kazumasa、Naito Sumiyoshi、Yoshida Mika、Saito Makoto、Kiyohara Kazuki、Miyazima Shinri、Maeta Takahiro、Ohtsu Akihiro、Shimosegawa Kenji、Takahashi Nobuhiko、Ichinose Akitada
- Journal Title
  
  International Journal of Hematology
  
  Volume: 115 Issue: 1 Pages: 11-20
- DOI
  10.1007/s12185-021-03212-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07871
[Journal Article] Comparative evaluation of reagents for measuring protein S activity: possibility of harmonization2021
- Author(s)
  Ieko M, Hotta T, Watanabe K, Adachi T, Takeuchi S, Naito S, Yoshida M, Ohmura K, Takahashi N, Morishita E, Tsuda H, Kang D
- Journal Title
  
  Int J Hematol.
  
  Volume: 113 Issue: 4 Pages: 530-536
- DOI
  10.1007/s12185-020-03049-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H00530, KAKENHI-PROJECT-18K07442, KAKENHI-PROJECT-19K07871, KAKENHI-PROJECT-18K07486
[Journal Article] The antiphosphatidylserine/prothrombin detection in solid phase assay is largely dependent on the type of samples2020
- Author(s)
  Kumano Osamu、Ieko Masahiro、Yoshida Mika、Naito Sumiyoshi、Ohmura Kazumasa、Takahashi Nobuhiko
- Journal Title
  
  International Journal of Laboratory Hematology
  
  Volume: 42 Issue: 4
- DOI
  10.1111/ijlh.13226
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07871
[Journal Article] Novel assay based on diluted prothrombin time reflects anticoagulant effects of direct oral factor Xa inhibitors: Results of multicenter study in Japan2020
- Author(s)
  Ieko Masahiro、Ohmura Kazumasa、Naito Sumiyoshi、Yoshida Mika、Sakuma Ichiro、Ikeda Kozue、Ono Shouko、Suzuki Takeshi、Takahashi Nobuhiko
- Journal Title
  
  Thrombosis Research
  
  Volume: 195 Pages: 158-164
- DOI
  10.1016/j.thromres.2020.07.020
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07473, KAKENHI-PROJECT-19K07871
[Journal Article] Knockdown of long noncoding RNA dreh facilitates cell surface GLUT4 expression and glucose uptake through the involvement of vimentin in 3T3-L1 adipocytes2020
- Author(s)
  Nobuhiko Takahashi, Atsushi P. Kimura, Kazumasa Ohmura, Sumiyoshi Naito, Mika Yoshida, Masahiro Ieko
- Journal Title
  
  Gene
  
  Volume: 735 Pages: 144404-144404
- DOI
  10.1016/j.gene.2020.144404
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07871
[Journal Article] ラテックス免疫比濁法を用いた新規トロンビン・アンチトロンビン複合体測定試薬における抗プロトロンビン抗体の影響2020
- Author(s)
  吉田竜也、吉田美香、内藤澄悦、大村一将、高橋伸彦、家子正裕
- Journal Title
  
  臨床病理
  
  Volume: 68 Pages: 877-882
- NAID
  40022425533
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07871
[Journal Article] A novel testis-specific long noncoding RNA, Tesra, activates the Prss42/Tessp-2 gene during mouse spermatogenesis2019
- Author(s)
  Satoh Y., Takei N., Kawamura S., Takahashi N., Kotani T., and Kimura A.P.
- Journal Title
  
  Biology of Reproduction
  
  Volume: 100 Issue: 3 Pages: 833-848
- DOI
  10.1093/biolre/ioy230
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H04317, KAKENHI-PROJECT-17J05929, KAKENHI-PROJECT-16K08939
[Journal Article] Dreh, a long noncoding RNA repressed by metformin, regulates glucose transport in C2C12 skeletal muscle cells2019
- Author(s)
  Nobuhiko Takahashi, Atsushi P. Kimura, Kai Otsuka, Kazumasa Ohmura, Sumiyoshi Naito, Mika Yoshida, Masahiro Ieko
- Journal Title
  
  Life Sciences
  
  Volume: 236 Pages: 116906-116906
- DOI
  10.1016/j.lfs.2019.116906
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07871
[Journal Article] Basic Evaluation of the Newly Developed "Lias Auto P-FDP" Assay and the Influence of Plasmin-α2 Plasmin Inhibitor Complex Values on Discrepancy in the Comparison with "Lias Auto D-Dimer Neo" Assay2018
- Author(s)
  Kumano Osamu、Ieko Masahiro、Komiyama Yutaka、Naito Sumiyoshi、Yoshida Mika、Takahashi Nobuhiko、Ohmura Kazumasa、Hayasaki Junki、Hayakawa Mineji
- Journal Title
  
  Clinical Laboratory
  
  Volume: 64 Issue: 04/2018 Pages: 433-442
- DOI
  10.7754/clin.lab.2017.170902
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08939
[Journal Article] 血栓症の血液バイオマーカー2018
- Author(s)
  家子正裕、大村一将、高橋伸彦
- Journal Title
  
  日本臨床
  
  Volume: 76 Pages: 1529-1535
- Data Source
  KAKENHI-PROJECT-16K08939
[Journal Article] Sarcolipin expression is repressed by endoplasmic reticulum stress in C2C12 myotubes2017
- Author(s)
  Takahashi Nobuhiko、Kimura Atsushi P.、Naito Sumiyoshi、Yoshida Mika、Kumano Osamu、Suzuki Takeshi、Itaya Satoshi、Moriya Mitsuru、Tsuji Masahiro、Ieko Masahiro
- Journal Title
  
  Journal of Physiology and Biochemistry
  
  Volume: 73 Issue: 4 Pages: 531-538
- DOI
  10.1007/s13105-017-0578-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08939, KAKENHI-PROJECT-15K08621
[Journal Article] Profiles of direct oral anticoagulants and clinical usage-dosage and dose regimen differences.2016
- Author(s)
  Ieko M, Naitoh S, Yoshida M, Takahashi N.
- Journal Title
  
  J Intensive Care.
  
  Volume: 10 Issue: 1 Pages: 4-19
- DOI
  10.1186/s40560-016-0144-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K08616, KAKENHI-PROJECT-15K08621
[Journal Article] The production of coagulation factor VII by adipocytes is enhanced by tumor necrosis factor-α or isoproterenol2015
- Author(s)
  N Takahashi, T Yoshizaki, N Hiranaka, O Kumano, T Suzuki, M Akanuma, T Yui, K Kanazawa, M Yoshida, S Naito, M Fujiya, Y Kohgo, M Ieko
- Journal Title
  
  International Journal of Obesity
  
  Volume: 39 Issue: 5 Pages: 747-754
- DOI
  10.1038/ijo.2014.208
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25460696, KAKENHI-PROJECT-26460956, KAKENHI-PROJECT-15K08616
[Journal Article] Index of circulating anticoagulant cut-off value establishment in activated partial thromboplastin time mixing test for lupus anticoagulant diagnosis2013
- Author(s)
  Kumano O, Ieko M, Naito S, Yoshida M, Takahashi N, Aoki T
- Journal Title
  
  J Thromb Haemost
  
  Volume: 11 Pages: 1919-1922
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590684
[Journal Article] Index of circulating anticoagulant cut-off value establishment in activated partial thromboplastin time mixing test for lupus anticoagulant diagnosis.2013
- Author(s)
  Kumano O, Ieko M, Naito S, Yoshida M, Takahashi N, Aoki T.
- Journal Title
  
  J Thromb Haemost.
  
  Volume: 11 Issue: 10 Pages: 1919-1922
- DOI
  10.1111/jth.12345
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590684
[Journal Article] APTT reagent with ellagic acid as activator shows adequate lupus anticoagulant sensitivity in comparison to silica-based reagent2012
- Author(s)
  Kumano O, Ieko M, Naito S, Yoshida M, Takahashi N
- Journal Title
  
  J Thromb Haemost
  
  Volume: 10 Pages: 2338-2343
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590684
[Journal Article] 脂質代謝調節酵素lipin-1のメタボリックシンドロームにおける意義2010
- Author(s)
  土屋慶容、高橋伸彦, 他
- Journal Title
  
  旭川医科大学研究フォーラム
  
  Volume: 10巻 Pages: 102-103
- NAID
  120002063236
- Data Source
  KAKENHI-PROJECT-21790857
[Journal Article] 脂質代謝調節酵素1ipin-1のメタボリックシンドロームにおける意義2010
- Author(s)
  土屋慶容、高橋伸彦、奥村利勝
- Journal Title
  
  旭川医科大学研究フォーラム Vo.10
  
  Pages: 102-103
- Data Source
  KAKENHI-PROJECT-21790857
[Journal Article] 消化管上皮および脂肪細胞におけるlipinの機能と発現解析2009
- Author(s)
  高橋伸彦、藤谷幹浩、高後裕
- Journal Title
  
  分子消化器病 Vo.6、No.4
  
  Pages: 375-382
- Data Source
  KAKENHI-PROJECT-21790857
[Journal Article] A Jak2 inhibitor, AG490, reverses lipin-1 suppression by INF-α in 313-L1 adipocytes2009
- Author(s)
  Tsuchiya Y, Takahashi N, Yoshizaki T, Tanno S, Ohhira M, Motomua W, Tanno S, Takakusaki K, Kohgo Y, Okumura T.
- Journal Title
  
  Biochem.Biophys.Res.Commun. Vo.382
  
  Pages: 348-352
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790857
[Journal Article] A Jak2 inhibitor, AG490, reverses lipin-1 suppression by TNF-α in 3T3-L1 adipocytes2009
- Author(s)
  Tsuchiya Y, Takahashi N, Yoshizaki T, Tanno S, Ohhira M, Motomua W, Tanno S, Takakusaki K, Kohgo Y, Okumura T
- Journal Title
  
  Biochem. Biophys. Res. Commun. 382
  
  Pages: 348-352
- NAID
  120003203373
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790623
[Journal Article] A diacylglycerol kinase inhibitor, R59022, stimulates glucose transport through a MKK3/6-p38 signaling pathway in skeletal muscle cells.2007
- Author(s)
  Nobuhiko Takahashi, et. al.
- Journal Title
  
  Biochem Biophys Res Commun 360
  
  Pages: 244-250
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790623
[Journal Article] A diacylglycerol kinase inhibitor, R59022, stimulates glucose transport through a MKK3/6-p38 signaling pathway in skeletal muscle cells2007
- Author(s)
  Takahashi N, Nagamine M, Tanno S, Motomura W, Kohgo Y, Okumura T
- Journal Title
  
  Biochem. Biophys. Res. Commun. 360
  
  Pages: 244-250
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790623
[Presentation] 新規経口糖尿病治療薬imegliminは3T3-L1脂肪細胞の糖取り込みを促進する2023
- Author(s)
  高橋伸彦、木村敦、大村一将
- Organizer
  第26回アディポサイエンスシンポジウム
- Data Source
  KAKENHI-PROJECT-22K07403
[Presentation] Imeglimin affects mitochondrial function and DNA content in 3T3-L1 adipocytes2023
- Author(s)
  Nobuhiko Takahashi, Atsushi P. Kimura, Kazumasa Ohmura
- Organizer
  The 15th Scientific Meeting of The Asian Association fot the Study of Diabetes
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07403
[Presentation] イメグリミンは脂肪細胞に作用し, Fibroblast Growth Factor 21の産生・分泌を促進する2023
- Author(s)
  高橋伸彦、木村敦、大村一将
- Organizer
  第66回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-22K07403
[Presentation] 凝固第V因子インヒビター症例における抗凝固因子抗体量測定の意義2021
- Author(s)
  内藤澄悦、家子正裕、吉田美香、大村一将、高橋伸彦、森谷満
- Organizer
  第22回日本検査血液学会学術集会
- Data Source
  KAKENHI-PROJECT-19K07871
[Presentation] 後天性血友病Aにおける抗凝固因子抗体量測定の意義2021
- Author(s)
  吉田美香、家子正裕、内藤澄悦、大村一将、斉藤誠、高橋伸彦
- Organizer
  第22回日本検査血液学会学術集会
- Data Source
  KAKENHI-PROJECT-19K07871
[Presentation] 3T3-L1細胞において長鎖非コードRNA-Drehのノックダウンはvimentinを介したGLUT4の細胞膜発現増加によって糖取り込みを促進する2020
- Author(s)
  高橋伸彦、木村敦、大村一将、内藤澄悦、吉田美香、家子正裕
- Organizer
  第63回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-19K07871
[Presentation] 直接経口抗凝固薬治療中の出血予測因子について2020
- Author(s)
  内藤澄悦、大村一将、家子正裕、吉田美香、鈴木健史、高橋伸彦、小野尚子、佐久間一郎
- Organizer
  第21回日本検査血液学会学術集会
- Data Source
  KAKENHI-PROJECT-19K07871
[Presentation] 中性脂肪合成酵素lipin1の脂肪細胞における役割:炎症とのクロストーク2019
- Author(s)
  高橋伸彦, 吉崎隆之, 内藤澄悦, 吉田美香, 大村一将, 家子正裕
- Organizer
  中性脂肪学会第3回学術集会
- Data Source
  KAKENHI-PROJECT-19K07871
[Presentation] C2C12骨格筋細胞においてlncRNA-AK050349はメトフォルミンによって発現が低下し, その発現低下は糖取り込みを増加させる2019
- Author(s)
  高橋伸彦, 木村敦, 大村一将, 内藤澄悦, 吉田美香, 家子正裕
- Organizer
  第62回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-19K07871
[Presentation] Dilute prothrombin time is associated with the plasma drug concentrations, contributing to be comparable with anticoagulant effects as a measuring test for Direct oral anticoagulants targeted to factor Xa therapy: Results from multicenter study2019
- Author(s)
  Kazumasa Ohmura, Masahiro Ieko, Sumiyoshi Naito, Mika Yoshida, Takeshi Suzuki, Nobuhiko Takahashi, Shoko Ono, Kozue Ikeda, Ichiro Sakuma
- Organizer
  XXXII International Symposium on Technical Innovations in Laboratory Hematology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07473
[Presentation] Measuring the Anticoagulant Effect of Direct Oral Anticoagulants Targeted to Factor Xa Using the Ratio of Inhibited Thrombin Generation based on Dilute Prothrombin Time: Results from Multicenter Study2019
- Author(s)
  Kazumasa Ohmura, Masahiro Ieko, Sumiyoshi Naito, Mika Yoshida, Takeshi Suzuki, Nobuhiko Takahashi, Shoko Ono, Kozue Ikeda, Ichiro Sakuma
- Organizer
  The XXVII Congress of the International Society on Thrombosis and Haemostatis
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07473
[Presentation] LncRNA Drehの発現低下は骨格筋細胞および脂肪細胞でのグルコース取り込みを促進する2019
- Author(s)
  高橋伸彦, 木村敦, 大塚海, 大村一将, 内藤澄悦, 吉田美香, 家子正裕
- Organizer
  第24回アディポサイエンス・シンポジウム
- Data Source
  KAKENHI-PROJECT-19K07871
[Presentation] 抗C1qモノクローナル抗体による流産モデルマウスの検討2018
- Author(s)
  大村一将、奥健志、吉田美香、内藤澄悦、高橋伸彦、渥美達也、家子正裕
- Organizer
  第19回日本検査血液学会学術集会
- Data Source
  KAKENHI-PROJECT-16K08939
[Presentation] The comparison between fibrin monomer complex and soluble fibrin reagents in thrombosis markers from the view of fibrinolysis proceeding situation2018
- Author(s)
  Osamu Kumano、Masahiro Ieko、Yutaka Komiyama、Sumiyoshi Naito、Mika Yohida、Nobuhiko Takahashi、Kazumasa Ohmura、Junki Hayasaki、Mineji Hayakawa
- Organizer
  The 10th Congress of the Asian-Pacific Society on Thrombosis and Hemostasis
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08939
[Presentation] 我が国におけるループスアンチコアグラント関連凝固異常症の6年間の集積とその解析2018
- Author(s)
  吉田美香、家子正裕、内藤澄悦、大村一将、高橋伸彦、森谷満
- Organizer
  第19回日本検査血液学会学術集会
- Data Source
  KAKENHI-PROJECT-16K08939
[Presentation] マウス精巣特異的lncRNA Tesraの発現パターンと転写活性化における機能2018
- Author(s)
  佐藤優衣、武井夏海、川村翔平、高橋伸彦、小谷友也、山本雄広、渡辺健宏、松原伸、佐竹炎、木村敦
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-16K08939
[Presentation] Metforminによって発現が変化する骨格筋細胞内long noncoding RNAに関する検討2018
- Author(s)
  高橋伸彦、木村敦、大村一将、内藤澄悦、吉田美香、家子正裕
- Organizer
  第61回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-16K08939
[Presentation] 直接経口抗凝固薬(DOAC)がクロスミキシンクグテストに及ぼす影響2018
- Author(s)
  内藤澄悦、家子正裕、佐久間一郎、鈴木健史、熊野穣、吉田美香、高橋伸彦、若宮伸隆、森谷満
- Organizer
  第40回日本血栓止血学会学術集会
- Data Source
  KAKENHI-PROJECT-16K08939
[Presentation] MCP-1を指標とした血管内皮細胞におけるFXaによる炎症応答の検討2018
- Author(s)
  大村一将、内藤澄悦、吉田美香、高橋伸彦、家子正裕
- Organizer
  第65回日本臨床検査医学会学術集会
- Data Source
  KAKENHI-PROJECT-16K08939
[Presentation] 第19回日本検査血液学会学術集会2018
- Author(s)
  熊野穣、家子正裕、小宮山豊、内藤澄悦、吉田美香、高橋伸彦、大村一将、早崎淳貴、早川峰司
- Organizer
  救急領域における線溶亢進検体を用いたリアスオートP-FDP試薬の反応性評価
- Data Source
  KAKENHI-PROJECT-16K08939
[Presentation] 凝固因子活性低下を伴うループスアンチコアグラント症例における凝固因子インヒビター量の確認の意義2017
- Author(s)
  吉田美香, 内藤澄悦, 大村一将, 高橋伸彦, 家子正裕
- Organizer
  第18回日本検査血液学会学術集会
- Data Source
  KAKENHI-PROJECT-16K08939
[Presentation] 経口直接Xa阻害薬療法おける抗凝固効果の確認に関する検討2017
- Author(s)
  1.鈴木健史, 家子正裕, 高橋伸彦，内藤澄悦，吉田美香，熊野穣，畑中大希，末武司，小宮山豊，佐久間一郎
- Organizer
  第18回日本検査血液学会学術集会
- Data Source
  KAKENHI-PROJECT-15K08621
[Presentation] 遺伝性血栓性素因の検査における現状と問題点2017
- Author(s)
  家子正裕, 内藤澄悦, 吉田美香, 高橋伸彦, 津田博子
- Organizer
  第39回日本血栓止血学会学術集会
- Data Source
  KAKENHI-PROJECT-16K08939
[Presentation] New evaluation test for direct oral factor Xa inhibitors using diluted prothrombin time2017
- Author(s)
  Naito S, Ieko M, Suzuki T, Yoshida M, Omura K, Takahashi N, Moriya M, Wakamiya N, Sakuma I
- Organizer
  The 29th World Congress of World Association of Societies of Pathology and Laboratory Medicine
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08621
[Presentation] lupus anticoagulant 陽性症例に認められる凝固因子インヒビター活性の確認2017
- Author(s)
  内藤澄悦, 家子正裕, 吉田美香, 鈴木健史, 高橋伸彦, 若宮伸隆, 森谷満
- Organizer
  第39回日本血栓止血学会学術集会
- Data Source
  KAKENHI-PROJECT-16K08939
[Presentation] 身体活動量に着目した２型糖尿病患者における筋肉量減少因子の検討2017
- Author(s)
  日野里恵, 金森麻衣, 澤田篤史, 姫野陽子, 長谷佳子, 横田広子, 板谷利, 森谷満, 高橋伸彦, 井出肇, 辻昌宏
- Organizer
  第51回日本糖尿病学会北海道地方会
- Data Source
  KAKENHI-PROJECT-16K08939
[Presentation] 経口直接Xa阻害薬療法における抗凝固効果の確認に関する検討2017
- Author(s)
  鈴木健史, 家子正裕, 高橋伸彦, 内藤澄悦, 吉田美香, 熊野穣, 畑中大希, 末武司, 小宮山豊, 佐久間一郎
- Organizer
  第18回日本検査血液学会学術集会
- Data Source
  KAKENHI-PROJECT-16K08939
[Presentation] Fibrin Monomer complex and diluted prothrombin time as a marker for thrombotic tendency in anti-Xa DOAC therapy.2017
- Author(s)
  Suzuki T, Ieko M, Naito S, Yoshida M, Komiyama Y, Hatanaka D, Kumano O, Suetake T, Takahashi N, Sakuma I
- Organizer
  The 26th International Society on Thrombosis and Haemostasis Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08621
[Presentation] インスリン長時間暴露による骨格筋および脂肪細胞内long noncoding RNAの変化2017
- Author(s)
  高橋伸彦, 木村敦, 内藤澄悦, 吉田美香, 家子正裕
- Organizer
  第60回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-16K08939
[Presentation] 小胞体ストレスはC2C12筋管細胞においてsarcolipin遺伝子発現を低下させる2016
- Author(s)
  高橋伸彦、内藤澄悦、吉田美香、熊野穣、鈴木健史、板谷利、森谷満、辻昌宏、家子正裕
- Organizer
  第58回日本糖尿病学会年次学術集会
- Place of Presentation
  京都市
- Year and Date
  2016-05-19
- Data Source
  KAKENHI-PROJECT-25460696
[Presentation] エドキサバン療法における希釈プロトロンビン時間を用いた残存凝固能（RITG）の測定2016
- Author(s)
  内藤済悦、家子正裕、佐久間一郎、鈴木健史、熊野穣、吉田美香、高橋伸彦、四倉昭彦、ほか
- Organizer
  第38回日本血栓止血学会
- Place of Presentation
  奈良市
- Year and Date
  2016-06-16
- Data Source
  KAKENHI-PROJECT-15K08621
[Presentation] Edoxaban服用者における血栓マーカーを用いたRatio of Inhibited Thrombin Generationの評価2016
- Author(s)
  鈴木健史、家子正裕、佐久間一郎、熊野穣、内藤済悦、吉田美香、高橋伸彦、四倉昭彦、ほか
- Organizer
  第38回日本血栓止血学会
- Place of Presentation
  奈良市
- Year and Date
  2016-06-16
- Data Source
  KAKENHI-PROJECT-15K08621
[Presentation] 経口Xa阻害薬における抗凝固効果の新たな確認試験2016
- Author(s)
  内藤済悦、家子正裕、佐久間一郎、鈴木健史、熊野穣、吉田美香、高橋伸彦、四倉昭彦、ほか
- Organizer
  第36回日本臨床検査医学会
- Place of Presentation
  神戸市
- Year and Date
  2016-09-01
- Data Source
  KAKENHI-PROJECT-15K08621
[Presentation] 直接経口抗凝固薬の抗凝固効果から有用性と限界を探る2016
- Author(s)
  家子正裕、内藤済悦、吉田美香、高橋伸彦
- Organizer
  第37回日本臨床薬理学会
- Place of Presentation
  米子市
- Year and Date
  2016-12-01
- Invited
- Data Source
  KAKENHI-PROJECT-15K08621
[Presentation] Adipocytes secrete coagulation factor VII2015
- Author(s)
  Nobuhiko Takahashi, Takayuki Yoshizaki, Natsumi Hiranaka, Osamu Kumano, Takeshi Suzuki, Mika Yoshida, Sumiyoshi Naito, Mikihiro Fujiya, Yutaka Kohgo, Masahiro Ieko.
- Organizer
  The 8th Asia-Oceania Conference on Obesity
- Place of Presentation
  名古屋市
- Year and Date
  2015-10-02
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460696
[Presentation] THP-1マクロファージはlipopolysaccharide刺激によって血液凝固第VII因子を分泌する2015
- Author(s)
  高橋伸彦、吉崎隆之、熊野穣、鈴木健史、吉田美香、内藤澄悦、森谷満、辻宏昌、高後裕、家子正裕
- Organizer
  第58回日本糖尿病学会年次学術集会
- Place of Presentation
  下関市
- Year and Date
  2015-05-22
- Data Source
  KAKENHI-PROJECT-25460696
[Presentation] 凝固第VII因子は脂肪細胞より分泌され、肥満症の病態マーカーの可能性を有する2014
- Author(s)
  高橋伸彦, 吉崎隆之, 平中奈津弥, 熊野穣, 鈴木健史, 吉田美香, 内藤澄悦, 高後裕, 家子正裕
- Organizer
  第15回日本検査血液学会学術集会
- Place of Presentation
  仙台国際センター (宮城県仙台市)
- Year and Date
  2014-07-21
- Data Source
  KAKENHI-PROJECT-25460696
[Presentation] 肥満症、糖尿病と血液凝固異常2014
- Author(s)
  高橋伸彦
- Organizer
  第12回日本検査血液学会北海道支部総会
- Place of Presentation
  北海道大学学友会会館フラテホール (北海道札幌市)
- Year and Date
  2014-06-14
- Invited
- Data Source
  KAKENHI-PROJECT-25460696
[Presentation] 3T3-L1脂肪細胞はイソプロテレノール刺激によって血液凝固第VII因子を分泌する2014
- Author(s)
  高橋伸彦、吉崎隆之、平中奈津弥、熊野穣、鈴木健史、吉田美香、内藤澄悦、高後裕、家子正裕
- Organizer
  第57回日本糖尿病学会年次学術集会
- Place of Presentation
  大阪国際会議場 (大阪府大阪市)
- Year and Date
  2014-05-23
- Data Source
  KAKENHI-PROJECT-25460696
[Presentation] 脂肪細胞は血液凝固第VII因子を分泌する2014
- Author(s)
  高橋伸彦
- Organizer
  第35回日本肥満学会
- Place of Presentation
  シーガイアコンベンションセンター (宮崎県宮崎市)
- Year and Date
  2014-10-25
- Data Source
  KAKENHI-PROJECT-25460696
[Presentation] Lupus anticoagulants 検出におけるCross Mixing Testの新たな判定方法の評価と有用性2013
- Author(s)
  内藤済悦、家子正裕、吉田美香、森川千鶴、鈴木健史、高橋伸彦、伊藤喜久
- Organizer
  第35回　日本血栓止血学会
- Place of Presentation
  山形市
- Data Source
  KAKENHI-PROJECT-23590684
[Presentation] Lupus anticoagulants検出におけるCross Mixing Testの新たな判定方法の評価と有用性2013
- Author(s)
  内藤澄悦, 家子正裕, 吉田美香, 森川千鶴、鈴木健史、高橋伸彦、伊藤喜久
- Organizer
  第35回日本血栓止血学会学術集会
- Place of Presentation
  山形
- Year and Date
  2013-05-31
- Data Source
  KAKENHI-PROJECT-23590684
[Presentation] スコアリングを用いたCross Mixing TestによるLupus anticoagulantの検出2013
- Author(s)
  内藤澄悦, 家子正裕, 吉田美香, 森川千鶴, 鈴木健史, 高橋伸彦, 伊藤喜久
- Organizer
  第13回TTMフォーラム
- Place of Presentation
  東京
- Year and Date
  2013-03-09
- Data Source
  KAKENHI-PROJECT-23590684
[Presentation] APTTによるLA感度の指標に用いられるICAのカットオフ値の検討2013
- Author(s)
  熊野穣, 家子正裕, 内藤澄悦, 吉田美香, 高橋伸彦, 青木隆
- Organizer
  第47回日本臨床検査医学会北海道支部総会
- Place of Presentation
  札幌
- Year and Date
  2013-09-21
- Data Source
  KAKENHI-PROJECT-23590684
[Presentation] ループスアンチコアグラントの責任抗体に関する検討2013
- Author(s)
  吉田美香、内藤済悦、高橋伸彦、家子正裕
- Organizer
  第14回　日本検査血液学会
- Place of Presentation
  東京都
- Data Source
  KAKENHI-PROJECT-23590684
[Presentation] ループスアンチコアグラントの責任抗体に関する検討2013
- Author(s)
  吉田美香, 内藤澄悦, 高橋伸彦, 家子正裕
- Organizer
  第14回日本検査血液学会学術集会
- Place of Presentation
  東京
- Year and Date
  2013-07-27
- Data Source
  KAKENHI-PROJECT-23590684
[Presentation] 交差混合試験の新たな判定方法によるLA検出の評価と有用性2012
- Author(s)
  内藤澄悦、家子正裕、吉田美香、森川千鶴、鈴木健史、高橋伸彦、伊藤喜久
- Organizer
  第56回日本臨床検査医学会学術集会
- Place of Presentation
  京都市
- Data Source
  KAKENHI-PROJECT-23590684
[Presentation] 交差混合試験の新たな判定方法によるLA検出の評価と有用性2012
- Author(s)
  内藤澄悦, 家子正裕, 吉田美香, 森川千鶴, 鈴木健史, 高橋伸彦, 伊藤喜久
- Organizer
  第59回日本臨床検査医学会学術集会
- Place of Presentation
  京都
- Year and Date
  2012-11-30
- Data Source
  KAKENHI-PROJECT-23590684
[Presentation] β2GPI依存性抗カルジオリピン抗体(aCL)によるLA活性測定法の基礎的検討2012
- Author(s)
  鈴木健史, 家子正裕, 油井知雄, 岡和也, 内藤澄悦, 吉田美香, 高橋伸彦
- Organizer
  第34回日本血栓止血学会学術集会
- Place of Presentation
  東京
- Year and Date
  2012-06-08
- Data Source
  KAKENHI-PROJECT-23590684
[Presentation] 血漿サンプルの残存血小板がループスアンチコアグラント測定に及ぼす影響について2012
- Author(s)
  吉田美香, 内藤澄悦, 鈴木健史, 高橋伸彦, 家子正裕
- Organizer
  第12回TTMフォーラム
- Place of Presentation
  東京
- Year and Date
  2012-03-10
- Data Source
  KAKENHI-PROJECT-23590684
[Presentation] b2GPI依存性抗カルジオリピン抗体によるLA活性測定方法の基礎的検討2012
- Author(s)
  鈴木健史、家子正裕、由井知雄、岡　和也、内藤澄悦、吉田美香、高橋伸彦
- Organizer
  第34回日本血栓止血学会学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23590684
[Presentation] 3T3-L1脂肪細胞においてlipin-1遺伝子発現のknock downはMCP-1遺伝子発現上昇を引き起こす2011
- Author(s)
  高橋伸彦、吉崎隆之、高後裕、家子正裕
- Organizer
  第54回日本糖尿病学会年次学術集会
- Place of Presentation
  札幌市
- Year and Date
  2011-05-21
- Data Source
  KAKENHI-PROJECT-21790857
[Presentation] Lipin-1, a multifunctional metabolic regulator, is suppressed by TNF-α via Jak2 pathway in 3T3-L1 adipocytes2010
- Author(s)
  高橋伸彦
- Organizer
  第15回アディポサイエンス研究会シンポジウム
- Place of Presentation
  千里阪急ホテル(大阪府)
- Year and Date
  2010-08-21
- Data Source
  KAKENHI-PROJECT-21790857
[Presentation] Lipin-1, a multifunctional metabolic regulator, is suppressed by TNF-α via Jak2 pathway in 3T3-L1 adipocytes2010
- Author(s)
  高橋伸彦、土屋慶容、高後裕、家子正裕
- Organizer
  第15回アディポサイエンス研究会シンポジウム
- Place of Presentation
  大阪市
- Year and Date
  2010-08-21
- Data Source
  KAKENHI-PROJECT-21790857
[Presentation] TNF-αは3T3-L1脂肪細胞のlipin-1遺伝子発現を低下させる-Jak2経路の検証-2010
- Author(s)
  土屋慶容、高橋伸彦、高後裕
- Organizer
  第53回日本糖尿病学会年次学術集会
- Place of Presentation
  岡山市
- Year and Date
  2010-05-27
- Data Source
  KAKENHI-PROJECT-21790857
[Presentation] 3T3-L1脂肪細胞は血液凝固第VII因子を産生･分泌する
- Author(s)
  高橋伸彦、吉崎隆之、平中奈津弥、熊野穣、吉田美香、内藤澄悦、高後裕、家子正裕
- Organizer
  第47回日本糖尿病学会北海道地方会
- Place of Presentation
  札幌市
- Data Source
  KAKENHI-PROJECT-25460696
[Presentation] Expression of coagulant factor VII is induced by TNF-alpha in 3T3-L1 adipocytes
- Author(s)
  高橋伸彦、吉崎隆之、平中奈津弥、赤沼正康、吉田美香、内藤澄悦、熊野穣、高後裕、家子正裕
- Organizer
  第18回アディポサイエンスシンポジウム
- Place of Presentation
  大阪市
- Data Source
  KAKENHI-PROJECT-25460696

1. IEKO Masahiro (50250436)

# of Collaborated Projects: 5 results

# of Collaborated Products: 48 results
2. OKUMURA Toshikatsu (60281903)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
3. Ohmura Kazumasa (10803637)

# of Collaborated Projects: 3 results

# of Collaborated Products: 20 results
4. 木村敦 (90422005)

# of Collaborated Projects: 3 results

# of Collaborated Products: 13 results
5. YOSHIZAKI Takayuki (70515189)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
6. KUMAGAI kyoko

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. TSUCHIYA Yoshihiro (00516990)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
8. TANNO Satoshi (30333686)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 大平賀子 (30447106)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 吉崎由美子 (80452936)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. HIRANAKA Natsumi

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
12. JURAKU Hiroko

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 康東天

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

TAKAHASHI NOBUHIKO 高橋 伸彦

TAKAHASHI Nobuhiko 高橋 伸彦

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An exploratory study of extracellular mitochondrial proteins as novel markers of insulin resistance.Principal Investigator

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An exploratory study of extracellular proteins as novel markers of organ-specific glucose dysmetabolism.Principal Investigator

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Research on the development of an index for bleeding and thrombosis risk during direct oral anticoagulant treatment

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The investigation of long noncoding RNA in exosome as a marker for glucometabolism in organPrincipal Investigator

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Development of monitoring tests for residual coagulation activity in novel oral anticoagulants

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The role of factor seven activating protease in the pathogenesis of obesity-related disorders, and its potential applications as a clinical biomarkerPrincipal Investigator

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Standardization of the measuring method for lupus anticoagulant (LA)

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糖・脂質代謝研究に有用なin vitro小腸モデルの構築と臓器間相互作用の解析

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Regulatory mechanisms of lipin, a multifunctional metabolic regulator, and its therapeutic application for metabolic diseasesPrincipal Investigator

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中枢性迷走神経刺激による肝臓で発現する遺伝子発現変化の網羅的解析

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肝脂肪過剰蓄積を中枢へ伝達する迷走神経求心路刺激調節機構の解明と治療への応用

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Regulation of insulin receptor substrate through ubiquitin-proteasome pathwayPrincipal Investigator

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Molecular mechanism of the PPARγ ligand-induced growth arrest in GI cancers

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TAKAHASHI NOBUHIKO 高橋伸彦

TAKAHASHI Nobuhiko 高橋伸彦