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HIROYUKI MIYACHI  宮地 弘幸

… Alternative Names

MIYACHI Hiroyuki  宮地 弘幸

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Researcher Number 20376643
Other IDs
  • ORCIDhttps://orcid.org/0000-0002-3764-688X
Affiliation (based on the past Project Information) *help 2014 – 2015: 岡山大学, 医歯薬学総合研究科, 教授
2011 – 2015: 岡山大学, 医歯(薬)学総合研究科, 教授
2005 – 2006: 東京大学, 分子細胞生物学研究所, 助教授
Review Section/Research Field
Principal Investigator
Drug development chemistry
Except Principal Investigator
医薬分子機能学 / Biological pharmacy
Keywords
Principal Investigator
ピラゾール / フェノキシブタン酸 / FABP4 / FABP3リガンド / FABP3 / イソプラジオチン / 分子動力学シミュレーション法 / 非環状ビス(ビベンジル) / 膜障害 / リカルディン … More / ビス(ビベンジル) / 抗MRSA薬 / MRSA / フェニルプロピオン酸 / NOTCH / secretase / γセクレターゼ / チアゾリジンジオン / プロピオン酸 / PPAR / アルツハイマー … More
Except Principal Investigator
thalidomide / bioprobe / molecular design / enzyme inhibitor / antagonists / steroid hormone / structural development / nuclear receptor / 抗リウマチ活性 / 抗糖尿病活性 / 一酸化窒素 / シクロオキシゲナーゼ阻害剤 / 核内受容体 / エストロゲン / 抗アンドロゲン / レチノイド / 阻害剤 / シクロオキシゲナーゼ / ビタミンD_3 / 生物応答調節剤 / バチェラジン / チュブリン重合阻害剤 / 組胞分化誘導 / アンドロゲンアンタゴニスト / ビタミンDアンタゴニスト / プロテインキナーゼC / プロゲステロン / FXR / アンドロゲン / ビタミンD / ステロイド / PPAR / Farnesoid X Receptor (FXR) / Liver X Receptor (LXR) / 核内受容体リガンド / サリドマイド / 蛍光プローブ / 分子設計 / 酵素阻害剤 / アンタゴニスト / ステロイドホルモン / 構造展開 / 核内レセプター / 化学伝達 / ケトン体 / 塩素イオン / シナプス小胞 / ATP / グルタミン酸 / トランスポーター / 生化学 Less
  • Research Projects

    (5 results)
  • Research Products

    (36 results)
  • Co-Researchers

    (12 People)
  •  宿主脂質動態制御に基づくC型肝炎治療の化学基盤Principal Investigator

    • Principal Investigator
      宮地 弘幸
    • Project Period (FY)
      2015
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Drug development chemistry
    • Research Institution
      Okayama University
  •  ビス(ビベンジル)型天然物は新たな膜障害性抗MRSA薬となり得るか!Principal Investigator

    • Principal Investigator
      宮地 弘幸
    • Project Period (FY)
      2014 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Drug development chemistry
    • Research Institution
      Okayama University
  •  シナプス伝達におけるグルタミン酸充填量制御メカニズムの構造生物学的解明とその応用

    • Principal Investigator
      森山 芳則
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Biological pharmacy
    • Research Institution
      Okayama University
  •  Explolation of gamma-secretase modulator based on metabolic nuclear receptorPrincipal Investigator

    • Principal Investigator
      HIROYUKI MIYACHI
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Drug development chemistry
    • Research Institution
      Okayama University
  •  Design and development of biological response modifiers

    • Principal Investigator
      HASHIMOTO Yuichi
    • Project Period (FY)
      2002 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (S)
    • Research Field
      医薬分子機能学
    • Research Institution
      The University of Tokyo

All 2016 2015 2014 2013 2012 2011 2006 2005 Other

All Journal Article Presentation Patent

  • [Journal Article] Minimum structural requirements for cell membrane leakage-mediated anti-MRSA activity of macrocyclic bis(bibenzyl)s.2016

    • Author(s)
      Fujii K, Morita D, Onoda K, Kuroda T, Miyachi H.
    • Journal Title

      Bioorg. Med. Chem. Lett.

      Volume: 23 Issue: 9 Pages: 2324-2327

    • DOI

      10.1016/j.bmcl.2016.03.033

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26293027
  • [Journal Article] Riccardin C derivatives cause cell leakage in Staphylococcus aureus.2015

    • Author(s)
      Morita D, Sawada H, Ogawa W, Miyachi H, Kuroda T.
    • Journal Title

      Biochim Biophys Acta.

      Volume: 1848 Issue: 10 Pages: 2057-2064

    • DOI

      10.1016/j.bbamem.2015.05.008

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26293027
  • [Journal Article] Anti-MRSA activity of isoplagiochin-type macrocyclic bis(bibenzyl)s is mediated through cell membrane damage2015

    • Author(s)
      Kenji Onoda, Hiromi Sawada, Daichi Morita, Kana Fujii, Hiroaki Tokiwa, Teruo Kuroda, and Hiroyuki Miyachi
    • Journal Title

      Bio. Med. Chem.

      Volume: 23(13) Issue: 13 Pages: 3309-3316

    • DOI

      10.1016/j.bmc.2015.04.047

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25460157, KAKENHI-PROJECT-26293027
  • [Journal Article] Structure-guideddesign,synthesis and in vitro evaluation of a series of pyrazole-based fatty acid binding protein (FABP) 3 ligands2013

    • Author(s)
      Beniyama Y, Matsuno K, Miyachi H
    • Journal Title

      Bioorg. Med. Chem. Lett

      Volume: 3 Pages: 1662-1666

    • Data Source
      KAKENHI-PROJECT-23590128
  • [Journal Article] Design and synthesis of a series ofα-benzyl phenylpropanoic acid-type peroxisome proliferator-activated receptor (PPAR) gamma partial agonists with improved aqueous solubility2013

    • Author(s)
      Ohashi M, Oyama T, Putranto EW, Waku T, Nobusada H, Kataoka K, Matsuno K, Yashiro M, Morikawa K, Huh NH, Miyachi H
    • Journal Title

      Bioorg Med Chem

      Volume: 21(8) Pages: 2319-2332

    • Data Source
      KAKENHI-PROJECT-23590128
  • [Journal Article] Structure-guided design, synthesis and in vitro evaluation of a series of pyrazole-based fatty acid binding protein (FABP) 3 ligands.2013

    • Author(s)
      Beniyama Y, Matsuno K, Miyachi H.
    • Journal Title

      Bioorg Med Chem Lett.

      Volume: 23 Issue: 6 Pages: 1662-1666

    • DOI

      10.1016/j.bmcl.2013.01.054

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590128
  • [Journal Article] Peroxisome Proliferator-Activated Receptor delta Antagonists Inhibit Hepatitis C Virus RNA Replication2013

    • Author(s)
      Ban S, Ueda Y, Ohashi M, Matsuno K, Ikeda M, Kato N, Miyachi H
    • Journal Title

      Bioorg. Med. Chem. Lett

      Volume: 23(17) Pages: 4774-4778

    • Data Source
      KAKENHI-PROJECT-23590128
  • [Journal Article] Peroxisome proliferator-activated receptor delta antagonists inhibit hepatitis C virus RNA replication.2013

    • Author(s)
      Ban S, Ueda Y, Ohashi M, Matsuno K, Ikeda M, Kato N, Miyachi H.
    • Journal Title

      Bioorg Med Chem Lett.

      Volume: 23 Issue: 17 Pages: 4774-4778

    • DOI

      10.1016/j.bmcl.2013.07.005

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590128
  • [Journal Article] Design, synthesis and in vitro evaluation of a series of a-substituted phenylpropanoic acid PPARy agonists to further investigate the stereochemistry-activity relationship2012

    • Author(s)
      Masao Ohashi, et.al.
    • Journal Title

      Bioorg. Med Chem.

      Volume: 20 Issue: 21 Pages: 6375-6383

    • DOI

      10.1016/j.bmc.2012.08.061

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-12J07435, KAKENHI-PROJECT-22249006, KAKENHI-PROJECT-23590128
  • [Journal Article] Design, synthesis and in vitro evaluation of a series ofα-substituted phenylpropanoic acid PPARγagonists to further investigate the stereochemistry-activity relationship2012

    • Author(s)
      Ohashi M, Nakagome I, Kasuga J, Nobusada H, Matsuno K, Makishima M, Hirono S, Hashimoto Y, Miyachi H
    • Journal Title

      Bioorg. Med. Chem

      Volume: 20 Pages: 375-383

    • Data Source
      KAKENHI-PROJECT-23590128
  • [Journal Article] Peroxisome proliferator-activated receptors (PPARs) have multiple binding points2012

    • Author(s)
      Kuwabara N, Oyama T, Tomioka D, Ohashi M, Yanagisawa J, Shimizu T, Miyachi H.
    • Journal Title

      J. Med.Chem.

      Volume: 55 Issue: 2 Pages: 893-902

    • DOI

      10.1021/jm2014293

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590128, KAKENHI-PROJECT-23770105, KAKENHI-PLANNED-23116007
  • [Journal Article] Bidirectional fluorescence properties of pyrene-based peroxisome proliferator-activated receptor (PPAR) α/δ dual agonist.2012

    • Author(s)
      Shintaro Ban 他7名
    • Journal Title

      Bioorganic & Medicinal Chemistry

      Volume: 20 Issue: 11 Pages: 3460-3464

    • DOI

      10.1016/j.bmc.2012.04.015

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22249006, KAKENHI-PROJECT-23247016, KAKENHI-PROJECT-23590128, KAKENHI-PROJECT-24370046
  • [Journal Article] Structure-based design, synthesis, and nonalcoholic steatohepatitis (NASH)-preventive effect of phenylpropanoic acid peroxisome proliferator-activated receptor (PPAR)α-selective agonists2011

    • Author(s)
      Ban S, Kasuga J, Nakagome I, Nobusada H, Takayama F, Hirono S, Kawasaki H, Hashimoto Y, Miyachi H
    • Journal Title

      Bioorg. Med. Chem

      Volume: 19 Pages: 3183-3191

    • Data Source
      KAKENHI-PROJECT-23590128
  • [Journal Article] Design, Synthesis, and Structural Analysis of Phenylpropanoic Acid-Type PPARγ-Selective Agonists : Discovery of Reversed Stereochemistry-Activity Relationship2011

    • Author(s)
      Ohashi M, Oyama T, Nakagome I, Satoh M, Nishio Y, Nobusada H, Hirono S, Morikawa K, Hashimoto Y, Miyachi H
    • Journal Title

      J. Med. Chem

      Volume: 54 Pages: 331-341

    • Data Source
      KAKENHI-PROJECT-23590128
  • [Journal Article] Design and synthesis of substituted phenylpropanoic acid derivatives as human peroxisome proliferators-activated receptor α/σ dual agonists.2006

    • Author(s)
      J.Kasuga, M.Makishima, Y.Hashimoto, H.Miyachi
    • Journal Title

      Bioorganic & Medicinal Chemistry Letters 16・3

      Pages: 554-558

    • Data Source
      KAKENHI-PROJECT-14103018
  • [Journal Article] Novel non-steroidal/non-anilide type androgen antagonists : discovery of 4-substituted pyrrole-2-carboxamides as a new scaffold for androgen receptor ligand.2005

    • Author(s)
      K.Wakabayashi, H.Miyachi, Y.Hashimoto, A.Tanatani
    • Journal Title

      Bioorganic & Medicinal Chemistry 13・8

      Pages: 2837-2846

    • Data Source
      KAKENHI-PROJECT-14103018
  • [Patent] ポリアミンの化学伝達を司るトランスポーターの同定とその利用2015

    • Inventor(s)
      森山芳則,表 弘志,宮地孝明,日浅未来
    • Industrial Property Rights Holder
      森山芳則,表 弘志,宮地孝明,日浅未来
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2014-544325
    • Filing Date
      2015-03-15
    • Data Source
      KAKENHI-PROJECT-25253008
  • [Patent] アスコルビン酸トランスポーター2014

    • Inventor(s)
      森山芳則,宮地孝明,表篠崎一雄ら
    • Industrial Property Rights Holder
      森山芳則,宮地孝明,表篠崎一雄ら
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2013-155640
    • Filing Date
      2014-08-04
    • Data Source
      KAKENHI-PROJECT-25253008
  • [Patent] 葉緑体へのアスコルビン酸濃縮を司るトランスポーターの同定とその利用2013

    • Inventor(s)
      森山芳則、宮地孝明、表弘志、黒森崇、篠崎一雄
    • Industrial Property Rights Holder
      森山芳則、宮地孝明、表弘志、黒森崇、篠崎一雄
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2013-155640
    • Filing Date
      2013-07-26
    • Data Source
      KAKENHI-PROJECT-25253008
  • [Patent] 置換イソキサゾール誘導体2006

    • Inventor(s)
      宮地弘幸, 貝沼雅彦, 橋本祐一
    • Industrial Property Rights Holder
      国立大学法人東京大学
    • Industrial Property Number
      2006-054501
    • Filing Date
      2006-03-01
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14103018
  • [Patent] 複素環誘導体2006

    • Inventor(s)
      棚谷綾, 宮地弘幸, 中川亜弥, 橋本祐一
    • Industrial Property Rights Holder
      国立大学法人東京大学
    • Industrial Property Number
      2006-021770
    • Filing Date
      2006-01-31
    • Data Source
      KAKENHI-PROJECT-14103018
  • [Presentation] 膜障害性抗MRSA活性を有する 大環状ビス(ビベンジル)型天然物誘導体の活性発現必須構造解析2016

    • Author(s)
      藤井佳那,森田大地,斧田賢嗣,澤田紘実,黒田照夫,宮地弘幸
    • Organizer
      日本薬学会第136年会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2016-03-26
    • Data Source
      KAKENHI-PROJECT-26293027
  • [Presentation] 抗MRSA薬を天然に学び創る2015

    • Author(s)
      宮地 弘幸
    • Organizer
      難治性感染症シンポジウム
    • Place of Presentation
      岡山大学50周年記念館
    • Year and Date
      2015-02-12
    • Invited
    • Data Source
      KAKENHI-PROJECT-26293027
  • [Presentation] マスト細胞における小胞型ポリアミントランスポーターの発現と機能2015

    • Author(s)
      竹内智也,原田結加,日浅未来,宮地孝明,表 弘志,森山芳則
    • Organizer
      日本薬学会第135年会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-25
    • Data Source
      KAKENHI-PROJECT-25253008
  • [Presentation] 膜障害性抗MRSA活性を有する 大環状ビス(ビベンジル)型天然物誘導体の活性発現必須構造解析2015

    • Author(s)
      藤井佳那,森田大地,斧田賢嗣,澤田紘実,黒田照夫,宮地弘幸
    • Organizer
      創薬懇話会
    • Place of Presentation
      グランドエクシブ鳴門 ザ・ロッジ
    • Year and Date
      2015-07-02
    • Data Source
      KAKENHI-PROJECT-26293027
  • [Presentation] 小胞型ポリアミントランスポーターの同定2014

    • Author(s)
      表 弘志,日浅未来,宮地孝明,竹内智也,原田結加,森山佐和子,森山芳則
    • Organizer
      第36回生体膜と薬物の相互作用シンポジウム
    • Place of Presentation
      徳島
    • Year and Date
      2014-11-20
    • Data Source
      KAKENHI-PROJECT-25253008
  • [Presentation] 質量分析による膜タンパク質の構造解析手法の構築2014

    • Author(s)
      河上麻美代,宮地孝明,川上朝子,樹下成信,表弘志,森山芳則
    • Organizer
      日本薬学会第134年会
    • Place of Presentation
      熊本
    • Data Source
      KAKENHI-PROJECT-25253008
  • [Presentation] ショウジョウバエ小胞型ヌクレオチドトランスポーターの同定2014

    • Author(s)
      加藤百合,宮地孝明,小泉拓也,Bram LARIDON,Patrick CALLAERTS,Koen NORGA,表弘志,森山芳則
    • Organizer
      日本薬学会第134年会
    • Place of Presentation
      熊本
    • Data Source
      KAKENHI-PROJECT-25253008
  • [Presentation] 中枢における新規小胞型ポリアミントランスポーターの発現および機能解析2014

    • Author(s)
      日浅未来,宮地孝明,竹内智也,表 弘志,森山芳則
    • Organizer
      第87回日本生化学会大会
    • Place of Presentation
      京都
    • Year and Date
      2014-10-15
    • Data Source
      KAKENHI-PROJECT-25253008
  • [Presentation] 副腎における小胞型ヌクレオチドトランスポーターのATP濃縮と放出機構2014

    • Author(s)
      宮地孝明,日浅未来,表弘志,森山芳則
    • Organizer
      日本薬学会第134年会
    • Place of Presentation
      熊本
    • Data Source
      KAKENHI-PROJECT-25253008
  • [Presentation] 血小板におけるVNUTを介したヌクレオチド蓄積機構2014

    • Author(s)
      外川奈津子,日浅未来,宮地孝明,表弘志,森山芳則
    • Organizer
      日本薬学会第134年会
    • Place of Presentation
      熊本
    • Data Source
      KAKENHI-PROJECT-25253008
  • [Presentation] 神経細胞における小胞型ヌクレオチドトランスポーターの局在と機能2013

    • Author(s)
      日浅未来, Max Larsson, 澤田啓介, 宮地孝明, 表 弘志, Vidar Gundersen, 森山芳則
    • Organizer
      第86回日本生化学会大会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-25253008
  • [Presentation] 新規NOTCH-sparingγセクレターゼ阻害剤の創製2011

    • Author(s)
      黒住元紀元、西尾淑暢、宮地弘幸、他
    • Organizer
      創薬懇話会2011
    • Place of Presentation
      ダイアモンド瀬戸内マリンホテル
    • Data Source
      KAKENHI-PROJECT-23590128
  • [Presentation] Bis(bibenzyl) 型天然物を先導化合物とした新規膜障害性抗 MRSA 薬の創製

    • Author(s)
      ○斧田賢嗣 ,森田大地 ,澤田紘実 ,石坪江梨花 , 松野研司,常盤広明 ,黒田照夫,宮地弘幸
    • Organizer
      メディシナルケミストリーシンポジウム
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      2014-11-26 – 2014-11-28
    • Data Source
      KAKENHI-PROJECT-26293027
  • [Presentation] Riccardin誘導体の抗菌活性と作用機序の解析

    • Author(s)
      森田大地、澤田紘実、小川和加野、宮地弘幸、黒田照夫
    • Organizer
      日本薬学会第135年会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-25 – 2015-03-28
    • Data Source
      KAKENHI-PROJECT-26293027
  • [Presentation] 構造生物学的構造活性相関に基づく創薬

    • Author(s)
      宮地 弘幸
    • Organizer
      CSJフェスタ
    • Place of Presentation
      タワーホール船堀
    • Year and Date
      2014-10-14 – 2014-10-16
    • Invited
    • Data Source
      KAKENHI-PROJECT-26293027
  • 1.  MATSUNO Kenji (50433214)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 6 results
  • 2.  HASHIMOTO Yuichi (90164798)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 3.  TANATANI Aya (40361654)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 4.  NAGASAWA Kazuo (10247223)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  ENDO Yasuyuki (80126002)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  KAGECHIKA Hiroyuki (20177348)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  森山 芳則 (10150658)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 8 results
  • 8.  井上 剛 (40370134)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  常盤 広明 (10221433)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 10.  黒田 照夫 (80304327)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 6 results
  • 11.  袖岡 幹子 (60192142)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  浦野 泰照 (20292956)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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