Sasaki Takamitsu 佐々木崇光

… Alternative Names

SASAKI Takamitsu 佐々木崇光

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Researcher Number	20382674
Other IDs
Affiliation (Current)	2025: 静岡県立大学, 薬学部, 客員共同研究員
Affiliation (based on the past Project Information) *help	2019 – 2021: 静岡県立大学, 薬学部, 客員共同研究員 2015 – 2018: 静岡県立大学, 薬学部, 講師 2011 – 2014: 東北薬科大学, 薬学部, 助教 2008 – 2010: Tohoku Pharmaceutical University, 薬学部, 助手 2005 – 2006: 東北薬科大学, 薬学部, 助手
Review Section/Research Field	Principal Investigator Medical pharmacy Except Principal Investigator Medical pharmacy / Basic Section 47060:Clinical pharmacy-related / Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related
Keywords	Principal Investigator iPS細胞 / 個人差 / 分子記述子 / P450 / DILI評価系 / cytochrome P450 / インビトロDILI 評価系 / Cytochrome P450 / インビトロ評価系 / DILI … More / 薬剤性肝障害 / CYP3A / 薬物代謝学 / 肝細胞 / レポーター遺伝子 / CYP3A4 / 転写因子 / トランスポーター / HNF / 肝特異的転写因子 / CYP / 肝分化誘導法 / iPS 細胞 / 代謝学 / 薬物動態 / DPD / マイクロRNA / 遺伝子多型 / 抗癌剤代謝酵素 / DHPLC / エピジェネティクス / TPMT … More Except Principal Investigator SNP / 肝臓 / PXR / 核内受容体 / Denaturing HPLC / CYP2D6 / 遺伝子多型 / ヒト腸管 / PPARγ / CYP3A4 / 臓器差 / 酵素誘導 / 薬物代謝酵素 / 腸管 / 1細胞質量分析 / 1細胞分析 / 誘導体化 / １細胞分析 / 質量分析 / メタボロミクス / ミトコンドリア / 種差 / 肝再生 / 肝細胞 / 肝 / 化学物質 / 細胞増殖 / 転写調節 / CAR / 分子間相互作用 / 抗炎症 / 医薬品副作用 / 肝がん / 化学発がん / 肝細胞増殖 / 肝毒性 / Pharmacogenetics / Genetic polymorphism / ファルマコジェネティクス / 蛋白質 / 遺伝子 / 薬剤反応性 / 酵素 / ゲノム / 肝障害 / メルカプトプリン / DHPLC / キサンチンオキシダーゼ Less

Development of mitochondrial mass spectrometry in live single-cell.
- Principal Investigator
  
  Mizuno Hajime
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related
- Research Institution
  University of Shizuoka
Elucidation of the molecular mechanism of CYP3A4 induction in the human intestine and its differences from the liver
- Principal Investigator
  
  Hosaka Takuomi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  University of Shizuoka
Nuclear receptor PXR-mediated hepatocyte proliferation: understanding of its mechanism and human relevance
- Principal Investigator
  
  Yoshinari Kouichi
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  University of Shizuoka
Development of evaluation methods for drug-induced liver injury based on both chemical structure/biological reactivity of drugs and individual factorsPrincipal Investigator
- Principal Investigator
  
  Sasaki Takamitsu
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  University of Shizuoka
Development of a model for the monitoring ontogenic expression of CYP3A by used of secreted reporter-expressing iPS cellsPrincipal Investigator
- Principal Investigator
  
  Sasaki Takamitsu
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  University of Shizuoka
  Tohoku Pharmaceutical University
Efficient generation of functional hepatocytes from human induced pluripotent stem cells and isolation of hepatic progenitor cellsPrincipal Investigator
- Principal Investigator
  
  SASAKI Takamitsu
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Tohoku Pharmaceutical University
Functional characterization of drug metabolizing enzyme genes and variant proteins
- Principal Investigator
  
  HIRATSUKA Masahiro
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Tohoku University
Analysis of epigenetic regulation of drug-metabolizing enzymes catalyzing anticancer drugsPrincipal Investigator
- Principal Investigator
  
  SASAKI Takamitsu
- Project Period (FY)
  2007 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Tohoku Pharmaceutical University
Analysis of genetic polymorphisms in human drug-metabolizing enzyme genes and functions of enzymatic proteins
- Principal Investigator
  
  MIZUGAKI Michinao
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Tohoku Pharmaceutical University
メルカプトプリン投与による肝障害とキサンチンオキシダーゼ(XO)遺伝子多型解析
- Principal Investigator
  
  KONNO Yumiko
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Medical pharmacy
- Research Institution
  Tohoku Pharmaceutical University

[Book] 創薬研究のストラテジー上2011
- Author(s)
  佐々木崇光、永田清
- Publisher
  金芳堂
- Data Source
  KAKENHI-PROJECT-20790142
[Book] 創薬研究のストラテジー上2011
- Author(s)
  佐々木崇光
- Publisher
  金芳堂
- Data Source
  KAKENHI-PROJECT-20790142
[Journal Article] Functional interaction between PXR and YAP in xenobiotic-dependent liver hypertrophy and drug metabolism.2019
- Author(s)
  Abe, T., Shizu, R., Sasaki, T., Shimizu, Y., Hosaka, T., Kodama, S., Matsuzawa, A., Yoshinari, K.
- Journal Title
  
  J. Pharmacol. Exp. Ther.
  
  Volume: 371 Issue: 3 Pages: 590-601
- DOI
  10.1124/jpet.119.258632
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H02567, KAKENHI-PROJECT-17K08418
[Journal Article] Possible involvement of the competition for the transcriptional coactivator glucocorticoid receptor-interacting protein 1 in the inflammatory signal-dependent suppression of PXR-mediated CYP3A induction in?vitro2019
- Author(s)
  Okamura Maya、Shizu Ryota、Hosaka Takuomi、Sasaki Takamitsu、Yoshinari Kouichi
- Journal Title
  
  Drug Metabolism and Pharmacokinetics
  
  Volume: 34 Issue: 4 Pages: 272-279
- DOI
  10.1016/j.dmpk.2019.04.005
- NAID
  50014558515
- Data Source
  KAKENHI-PROJECT-17K08418
[Journal Article] Discriminative models using molecular descriptors for predicting increased serum ALT levels in repeated-dose toxicity studies of rats2018
- Author(s)
  Takeshita Jun-ichi、Nakayama Haruka、Kitsunai Yoko、Tanabe Misako、Oki Hitomi、Sasaki Takamitsu、Yoshinari Kouichi
- Journal Title
  
  Computational Toxicology
  
  Volume: 6 Pages: 64-70
- DOI
  10.1016/j.comtox.2017.05.002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08419, KAKENHI-PROJECT-16K21674
[Journal Article] Screening of Industrial and Agricultural Chemicals for Searching a Mouse PXR Activator Using Cell-Based Reporter Gene Assays2018
- Author(s)
  Ryota Shizu, Makoto Kano, Taiki Abe, Saki Tsuchiya, Yuki Shimizu, Michiko Watanabe, Takuomi Hosaka, Takamitsu Sasaki, Kouichi Yoshinari
- Journal Title
  
  BPB Reports
  
  Volume: 1 Pages: 11-19
- NAID
  130007938427
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08418
[Journal Article] CYP3A4 induction mechanism of polycyclic aromatic hydrocarbons differs from that of rifampicin in PXR binding element2017
- Author(s)
  Yusuke Aratsu、Reo Odagiri、Rie Shoji、Kouki Watanabe、Takeshi Kumagai、Sawako Shindo、Takamitsu Sasaki、Kiyoshi Nagata
- Journal Title
  
  Fundamental Toxicological Sciences
  
  Volume: 4 Issue: 5 Pages: 229-239
- DOI
  10.2131/fts.4.229
- NAID
  130006144718
- ISSN
  2189-115X
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08419
[Journal Article] Effect of health foods on cytochrome P450-mediated drug metabolism2017
- Author(s)
  Sasaki Takamitsu、Sato Yu、Kumagai Takeshi、Yoshinari Kouichi、Nagata Kiyoshi
- Journal Title
  
  Journal of Pharmaceutical Health Care and Sciences
  
  Volume: 3 Issue: 1 Pages: 14-14
- DOI
  10.1186/s40780-017-0083-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08419
[Journal Article] Activation of nuclear receptor CAR by an environmental pollutant perfluorooctanoic acid.2017
- Author(s)
  Abe, T., Takahashi, M., Kano, M., Amaike, Y., Ishii, C., Maeda, K., Kudoh, Y., Morishita, T., Hosaka, T., Sasaki, T., Kodama, S., Matsuzawa, A., Kojima, H., Yoshinari, K.
- Journal Title
  
  Arch. Toxicol.
  
  Volume: 印刷中 Issue: 6 Pages: 2365-2374
- DOI
  10.1007/s00204-016-1888-3
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PUBLICLY-15H01168, KAKENHI-PUBLICLY-15H01391, KAKENHI-PROJECT-15H04780, KAKENHI-PROJECT-26293011, KAKENHI-PROJECT-25460195, KAKENHI-PROJECT-15K08791, KAKENHI-PUBLICLY-17H05518, KAKENHI-PROJECT-16K15146
[Journal Article] Construction of the Database of Rat Repeated-dose Toxicity Tests of Pesticides for the Toxicological Characterization of Hepatocyte Hypertrophy2017
- Author(s)
  増田茜、増田雅美、中島宏之、小島弘幸、北村繁幸、浦丸直人、保坂卓臣、佐々木崇光、吉成浩一―
- Journal Title
  
  YAKUGAKU ZASSHI
  
  Volume: 137 Issue: 5 Pages: 611-622
- DOI
  10.1248/yakushi.16-00259
- NAID
  130005631433
- ISSN
  0031-6903, 1347-5231
- Year and Date
  2017-05-01
- Language
  Japanese
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25460195, KAKENHI-PROJECT-16K00559, KAKENHI-PROJECT-17K15493
[Journal Article] Indirubin, a component of Ban-Lan-Gen, activates CYP3A4 gene transcription through the human pregnane X receptor2016
- Author(s)
  Kumagai　T, Aratsu　Y, Sugawara　R, Sasaki T, Miyairi　S, Nagata　K
- Journal Title
  
  Drug Metab Pharmacokinet
  
  Volume: 31 Issue: 2 Pages: 139-145
- DOI
  10.1016/j.dmpk.2016.01.002
- NAID
  50014431254
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460195
[Journal Article] CYP2A13 Genetic Polymorphisms in Relation to the Risk of Bladder Cancer in Japanese Smokers2016
- Author(s)
  Kumondai M, Hosono H, Orikasa K, Yoichi A, Sugimura H, Ozono S, Sugiyama T, Takayama T, Sasaki T, Hirasawa N, Hiratsuka M
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 39 Issue: 10 Pages: 1683-1686
- DOI
  10.1248/bpb.b16-00422
- NAID
  130005598497
- ISSN
  0918-6158, 1347-5215
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460195
[Journal Article] Activation of p38 Mitogen-Activated Protein Kinase by Clotrimazole Induces Multidrug Resistance-Associated Protein 3 Activation through a Novel Transcriptional Element2016
- Author(s)
  Sasaki T, Inami K, Numata Y, Funakoshi K, Yoshida M, Kumagai T, Kanno S, Matsui S, Toriyabe T, Yamazoe Y, Yoshinari K, Nagata K
- Journal Title
  
  J Pharmacol Exp Ther
  
  Volume: 31 Issue: 1 Pages: 102-109
- DOI
  10.1124/jpet.115.231589
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25460195
[Journal Article] Genetic Polymorphisms of CYP2A6 in a Case-Control Study on Bladder Cancer in Japanese Smokers2016
- Author(s)
 Kumondai M, Hosono H, Orikasa K, Yoichi A, Sugimura H, Ozono S, Sugiyama T, Takayama T, Sasaki T, Hirasawa N, Hiratsuka M
- Journal Title
 
 Biological and Pharmaceutical Bulletin
 
 Volume: 39 Issue: 1 Pages: 84-89
- DOI
 10.1248/bpb.b15-00604
- NAID
 130005116502
- ISSN
 0918-6158, 1347-5215
- Language
 English
- Peer Reviewed
- Data Source
 KAKENHI-PROJECT-25460195, KAKENHI-PROJECT-221S0001
[Journal Article] レポーター遺伝子導入培養細胞を用いた健康食品によるCYP1A1/1A2誘導の網羅的評価2016
- Author(s)
  熊谷健, 佐々木崇光, 永田清
- Journal Title
  
  医療薬学
  
  Volume: 42 Pages: 701-708
- NAID
  130006163861
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460195
[Journal Article] Development of a highly reproducible system to evaluate inhibition of cytochrome P450 3A4 activity by natural medicines.2015
- Author(s)
  Sato Y, Sasaki T, Takahashi S, Kumagai T, Nagata K
- Journal Title
  
  J Pharm Pharm Sci
  
  Volume: 18 Issue: 4 Pages: 316-327
- DOI
  10.18433/j3vk5g
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460195
[Journal Article] Simultaneous evaluation of human CYP3A4 and ABCB1 induction by reporter assay in LS174T cells, stably expressing their reporter genes2015
- Author(s)
  Inami K, Sasaki T, Kumagai T, Nagata K
- Journal Title
  
  Biopharm Drug Dispos.
  
  Volume: 36 Issue: 3 Pages: 139-147
- DOI
  10.1002/bdd.1927
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460195
[Journal Article] CYP2A6 genetic polymorphism is associated with decreased susceptibility to squamous cell lung cancer in Japanese smokers2015
- Author(s)
  Hosono H, Kumondai M, Arai T, Sugimura H, Sasaki T, Hirasawa N, Hiratsuka M
- Journal Title
  
  Drug Metab Pharmacokinet
  
  Volume: 30 Issue: 4 Pages: 263-268
- DOI
  10.1016/j.dmpk.2015.04.002
- NAID
  50014429961
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460195, KAKENHI-PROJECT-221S0001
[Journal Article] 培養細胞を用いた健康食品と医薬品との薬物相互作用の薬物相互作用の網羅的調査2015
- Author(s)
  熊谷健、佐々木崇光、佐藤裕、髙橋昌悟、細川正清、頭金正博、松永民秀、大森栄、永田清
- Journal Title
  
  東京都病院薬剤師会雑誌
  
  Volume: 64 Pages: 15-22
- Data Source
  KAKENHI-PROJECT-25460195
[Journal Article] An Efficient Method for Differentiation of Human Induced Pluripotent Stem Cells into Hepatocyte-like Cells Retaining Drug Metabolizing Activity2014
- Author(s)
  Kondo Y, Iwao T, Nakamura K, Sasaki T, Takahashi S, Kamada N, Matsubara T, Gonzalez FJ, Akutsu H, Miyagawa Y, Okita H, Kiyokawa N, Toyoda M, Umezawa A, Nagata K, Matsunaga T, Ohmori S
- Journal Title
  
  Drug Metabolism and Pharmacokinetics
  
  Volume: 29 Issue: 3 Pages: 237-243
- DOI
  10.2133/dmpk.DMPK-13-RG-104
- NAID
  130004463382
- ISSN
  1347-4367, 1880-0920
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390036, KAKENHI-PROJECT-25460195, KAKENHI-PROJECT-25860120
[Journal Article] 調剤薬局来局者を対象とした健康食品の使用実態調査とその情報に基づいたCYP2D6活性阻害評価2014
- Author(s)
  佐々木崇光, 熊谷健, 佐々木瞳, 稲見敬太, 佐藤裕, 髙橋昌悟, 松永民秀, 頭金正博, 細川正清, 大森栄, 永田清
- Journal Title
  
  医療薬学
  
  Volume: 40 Pages: 488-499
- NAID
  130005098367
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460195
[Journal Article] 健康食品と医薬品の併用は薬物相互作用をおこす？2014
- Author(s)
  永田清、熊谷健、佐々木崇光
- Journal Title
  
  医薬品相互作用研究
  
  Volume: 38 Pages: 23-30
- Data Source
  KAKENHI-PROJECT-25460195
[Journal Article] Hepatocyte Nuclear Factor 6 Activates the Transcription of CYP3A4 in Hepatocyte-like Cells Differentiated from Human Induced Pluripotent Stem Cells2013
- Author(s)
 Sasaki T, Takahashi S, Numata Y, Narita M, Tanaka Y, Kondo Y, Matsunaga T, Ohmori S, Nagata K
- Journal Title
 
 Drug Metabolism and Pharmacokinetics
 
 Volume: 28 Issue: 3 Pages: 250-259
- DOI
 10.2133/dmpk.DMPK-12-RG-132
- NAID
 130004463310
- ISSN
 1347-4367, 1880-0920
- Language
 English
- Peer Reviewed
- Data Source
 KAKENHI-PROJECT-22390028, KAKENHI-PROJECT-23790193
[Journal Article] Effects of Hypoxia-inducible Factor-1α Chemical Stabilizer, CoCl2 and Hypoxia on Gene Expression of CYP3As in Human Fetal Liver Cells2012
- Author(s)
 Suzuki E
- Journal Title
 
 Drug Metabolism and Pharmacokinetics
 
 Volume: 27 Issue: 4 Pages: 398-404
- DOI
 10.2133/dmpk.DMPK-11-RG-074
- NAID
 130004463262
- ISSN
 1347-4367, 1880-0920
- Language
 English
- Peer Reviewed
- Data Source
 KAKENHI-PROJECT-22390028, KAKENHI-PROJECT-23790193
[Journal Article] Polycyclic Aromatic Hydrocarbons Activate CYP3A4 Gene Transcription through Human Pregnane X Receptor2012
- Author(s)
  Kumagai T, Suzuki H, Sasaki T, Sakaguchi S, Miyairi S, Yamazoe Y, Nagata K
- Journal Title
  
  Drug Metabolism and Pharmacokinetics
  
  Volume: 27 Issue: 2 Pages: 200-206
- DOI
  10.2133/dmpk.DMPK-11-RG-094
- NAID
  130004463240
- ISSN
  1347-4367, 1880-0920
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590173, KAKENHI-PROJECT-23790193
[Journal Article] Progression Alcoholic and Non-alcoholic Steatohepatitis : Common Metabolic Aspects of Innate Immune System and Oxidative Stress.2011
- Author(s)
  S Sakaguchi, S Takahashi, T Sasaki, T Kumagai, K Nagata
- Journal Title
  
  Drug Metab.Pharmacokinet. 26
  
  Pages: 30-46
- NAID
  130004463160
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790142
[Journal Article] Association between Cancer Risk and Drug-metabolizing Enzyme Gene (CYP2A6, CYP2A13, CYP4B1, SULT1A1, GSTM1, and GSTT1) Polymorphisms in Cases of Lung Cancer in Japan2011
- Author(s)
  Tamaki, Y., Arai, T., Sugimura, H., Sasaki, T., Honda, M., Muroi, Y., Matsubara, Y., Kanno, S., Ishikawa, M., Hirasawa, N., Hiratsuka, M.
- Journal Title
  
  Drug Metabolism and Pharmacokinetics
  
  Volume: 26 Issue: 5 Pages: 516-522
- DOI
  10.2133/dmpk.DMPK-11-RG-046
- NAID
  130004463215
- ISSN
  1347-4367, 1880-0920
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22659025, KAKENHI-PROJECT-23790193, KAKENHI-PROJECT-221S0001
[Journal Article] Progression of Alcoholic and Non-alcoholic Steatohepatitis: Common Metabolic Aspects of Innate Immune System and Oxidative Stress2011
- Author(s)
  Sakaguchi S, Takahashi S, Sasaki T, Kumagai T, Nagata K
- Journal Title
  
  Drug Metabolism and Pharmacokinetics
  
  Volume: 26 Issue: 1 Pages: 30-46
- DOI
  10.2133/dmpk.DMPK-10-RV-087
- NAID
  130004463160
- ISSN
  1347-4367, 1880-0920
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590173, KAKENHI-PROJECT-23790193
[Journal Article] Functional characterization of genetic polymorphisms identified in the promoter region of the xanthine oxidase gene.2010
- Author(s)
  M Kudo, T Sasaki, M Ishikawa, N Hirasawa, M Hiratsuka
- Journal Title
  
  Drug Metab.Pharmacokinet. 25
  
  Pages: 599-604
- NAID
  10027743970
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790142
[Journal Article] Functional characterization of 26 CYP2B6 allelic variants (CYP2B6.2?CYP2B6.28, except CYP2B6.22).2010
- Author(s)
  Takashi Watanabe, Kanako Sakuyama, Takamitsu Sasaki, Yuya Ishii, Masaaki Ishikawa, Noriyasu Hirasawa, Masahiro Hiratsuka.
- Journal Title
  
  Pharmacogenet. Genom. 20
  
  Pages: 459-462
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590154
[Journal Article] Functional characterization of 26 CYP2B6 allelic variants (CYP2B6.2-CYP2B6.28 expect CYP2B6.22).2010
- Author(s)
  T Watanabe, K Sakuyama, T Sasaki, Y Ishii, M Ishikawa, N Hirasawa, M Hiratsuka
- Journal Title
  
  Pharmacogenet.Genomics. 20
  
  Pages: 459-462
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790142
[Journal Article] Kinetics of 6-thioxanthine metabolism by allelic variants of xanthine oxidase.2010
- Author(s)
  M Kudo, T Sasaki, M Ishikawa, N Hirasawa, M Hiratsuka
- Journal Title
  
  Drug Metab.Pharmacokinet. 25
  
  Pages: 361-366
- NAID
  10027583274
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790142
[Journal Article] Construction of a system that simultaneously evaluates CYP1A1 and CYP1A2 induction in a stable human-derived cell line using a dual reporter plasmid.2010
- Author(s)
  W Sato, H Suzuki, T Sasaki, T Kumagai, S Sakaguchi, M Mizugaki, S Miyairi, Y Yamazoe, K Nagata
- Journal Title
  
  Drug Metab.Pharmacokinet. 25
  
  Pages: 180-189
- NAID
  10027582549
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790142
[Journal Article] Genetic Variations in the HGPRT, ITPA, IMPDH1, IMPDH2, and GMPS genes in Japanese Individuals.2010
- Author(s)
  M Kudo, Y Saito, T Sasaki, H Akasaki, Y Yamaguchi, M Uehara, K Fujikawa, M Ishikawa, N Hirasawa, M Hiratsuka
- Journal Title
  
  Drug Metab.Pharmacokinet. 24
  
  Pages: 557-564
- NAID
  10027119756
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790142
[Journal Article] Malondialdehyde-modified low density lipoprotein (MDA-LDL)-induced cell growth was suppressed by polycyclic aromatic hydrocarbons (PAHs).2010
- Author(s)
  H Suzuki, T Sasaki, T Kumagai, S Sakaguchi, K Nagata
- Journal Title
  
  J.Toxicol.Sci. 35
  
  Pages: 137-147
- NAID
  10026193130
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790142
[Journal Article] Functional characterization of genetic polymorphisms identified in the promoter region of the xanthine oxidase gene.2010
- Author(s)
  Mutsumi Kudo, Takamitsu Sasaki, Masaaki Ishikawa, Noriyasu Hirasawa, Masahiro Hiratsuka.
- Journal Title
  
  Drug Metab. Pharmacokinet. 25
  
  Pages: 599-604
- NAID
  10027743970
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590154
[Journal Article] Kinetics of 6-thioxanthine metabolism by allelic variants of xanthine oxidase.2010
- Author(s)
  Mutsumi Kudo, Takamitsu Sasaki, Masaaki Ishikawa, Noriyasu Hirasawa, Masahiro Hiratsuka.
- Journal Title
  
  Drug Metab. Pharmacokinet. 25
  
  Pages: 361-366
- NAID
  10027583274
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590154
[Journal Article] Genetic variations in the HGPRT, ITPA, IMPDH1, IMPDH2, and GMPS genes in Japanese individuals.2009
- Author(s)
  Mutsumi Kudo, Yuka Saito, Takamitsu Sasaki, Hitomi Akasaki, Yuri Yamaguchi, Moe Uehara, Kiyomi Fujikawa, Masaaki Ishikawa, Noriyasu Hirasawa, Masahiro Hiratsuka.
- Journal Title
  
  Drug Metab. Pharmacokinet. 24
  
  Pages: 557-564
- NAID
  10027119756
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590154
[Journal Article] Functional characterization of 17 CYP2D6 allelic variants (CYP2D6.2, 10, 14A-B, 18, 27, 36, 39, 47-51, 53-55, and 57).2008
- Author(s)
  K Sakuyama, T Sasaki, S Ujiie, K Obata, M Mizugaki, M Ishikawa, M Hiratsuka
- Journal Title
  
  Drug Metab.Dispos. 36
  
  Pages: 2460-2467
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790142
[Journal Article] Functional characterization of 17 CYP2D6 allelic variants (CYP2D6.2, 10, 14A-B, 18, 27, 36, 39, 47-51, 53-55, and 57).2008
- Author(s)
  Kanako Sakuyama, Takamitsu Sasaki, Shuta Ujiie, Kanako Obata, Michinao Mizugaki, Masaaki Ishikawa, Masahiro Hiratsuka.
- Journal Title
  
  Drug Metab. Dispos. 36
  
  Pages: 2460-2467
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590154
[Journal Article] Functional characterization of 23 allelic variants of thiopurine S-methyltransferase gene (TPMT*2-*24).2008
- Author(s)
  S Ujiie, T Sasaki, M Mizugaki, M Ishikawa, M Hiratsuka
- Journal Title
  
  Pharmacogenet.Genomics 18
  
  Pages: 887-893
- NAID
  130005024445
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790142
[Journal Article] Possible relation between the risk of Japanese bladder cancer cases and CYP4B1 genotype2008
- Author(s)
  T Sasaki, M Horikawa, K Orikasa, M Sato, Y Arai, Y Mitachi, M Mizugaki, M Ishikawa, M Hiratsuka
- Journal Title
  
  Jpn.J.Clin.Oncol. 38
  
  Pages: 634-640
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790142
[Journal Article] Functional characterization of 23 allelic variants of thiopurine S-methyltransferase gene (TPMT*2-*24).2008
- Author(s)
  Shuta Ujiie, Takamitsu Sasaki, Michinao Mizugaki, Masaaki Ishikawa, Masahiro Hiratsuka.
- Journal Title
  
  Pharmacogenet. Genom. 18
  
  Pages: 887-893
- NAID
  130005024445
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590154
[Journal Article] Possible relation between the risk of Japanese bladder cancer cases and CYP4B1 genotype2008
- Author(s)
  Takamitsu Sasaki
- Journal Title
  
  Japanese Journal of Clinical Oncology 38
  
  Pages: 634-640
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790142
[Presentation] 肝のCYP3A4発現における肝星細胞の役割2021
- Author(s)
  伊豆倉裕翔、保坂卓臣、森田華帆、志津怜太、佐々木崇光、菅野裕一朗、吉成浩一
- Organizer
  日本薬物動態学会第36回年会
- Data Source
  KAKENHI-PROJECT-19K07226
[Presentation] 転写因子TFE3を介したヒト肝細胞におけるCYP3A4の転写調節2021
- Author(s)
  保坂卓臣、勝山早苗、志津怜太、佐々木崇光、菅野裕一朗、吉成浩一
- Organizer
  日本薬物動態学会第36回年会
- Data Source
  KAKENHI-PROJECT-19K07226
[Presentation] ヒト腸管由来LS180細胞でのrosiglitazoneによるCYP3A4誘導機序の解析2021
- Author(s)
  佐々木貴章、保坂卓臣、鶴田聡志、志津怜太、佐々木崇光、菅野裕一朗、吉成浩一
- Organizer
  日本薬物動態学会第36回年会
- Data Source
  KAKENHI-PROJECT-19K07226
[Presentation] ヒト腸管由来細胞でのrosiglitazoneによるCYP3A4誘導機序の解析2020
- Author(s)
  佐々木貴章、保坂卓臣、志津怜太、佐々木崇光、吉成浩一
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-19K07226
[Presentation] Development of mitochondria metabolomics using a novel mitochondria-localized photpaffinity probe2020
- Author(s)
  Hajime Mizuno, Natsumi Tanaka, Takamitsu Sasaki, Iwao Sakane, Eiji Sugiyama, Toshimasa Toyo’oka, Koichi Yoshinari, Shinobu Kudoh, Kenichiro Todoroki
- Organizer
  68th ASMS Conference on Mass Spectrometry
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07028
[Presentation] 化学物質によるPXR活性化のマウス肝発がんへの影響解析2020
- Author(s)
  志津怜太、石村麻衣、信澤純人、保坂卓臣、佐々木崇光、柿崎暁、吉成浩一
- Organizer
  第47回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-19K07226
[Presentation] トコンドリア局在型光反応プローブによる細胞内ミトコンドリア代謝物分析法の開発2020
- Author(s)
  水野初、田中奈津美、佐々木崇光、南哲平、杉山栄二、豊岡利正、吉成浩一、轟木堅一郎
- Organizer
  第68回質量分析総合討論会
- Data Source
  KAKENHI-PROJECT-19K07028
[Presentation] リガンド依存的なタンパク質構造変化に着目したPXR活性化評価系の構築2020
- Author(s)
  西口輝、志津怜太、保坂卓臣、佐々木崇光、菅野裕一朗、吉成浩一
- Organizer
  日本病院薬剤師会東海ブロック・日本薬学会東海支部合同学術大会2020
- Data Source
  KAKENHI-PROJECT-19K07226
[Presentation] ミトコンドリア局在型光反応プローブによる細胞内ミトコンドリア代謝物分析法の開発2020
- Author(s)
  水野初、田中奈津美、佐々木崇光、南哲平、杉山栄二、豊岡利正、吉成浩一、轟木堅一郎
- Organizer
  日本薬学会第１４０年会
- Data Source
  KAKENHI-PROJECT-19K07028
[Presentation] フェノバルビタールによる肝発がんへのPXR活性化の影響2019
- Author(s)
  石村麻衣、志津怜太、曽部圭一郎、江崎香奈子、保坂卓臣、佐々木崇光、吉成浩一
- Organizer
  フォーラム2019衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-17K08418
[Presentation] Interaction between CAR and YAP is a possible underlying mechanism of phenobarbital-dependent hepatocarcinogenesis and its species difference2019
- Author(s)
  Ryota Shizu, Taiki Abe, Keichiro Sobe, Mai Ishimura, Yuto Amaike, Takuomi Hosaka, Takamitsu Sasaki, Kouichi Yoshinari
- Organizer
  Cold Spring Harbor Asia meeting on Liver, Biology, Diseases & Cancer
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08418
[Presentation] 細胞内ミトコンドリア代謝物分析のための新規光反応プローブの開発2019
- Author(s)
  田中奈津美、水野初、佐々木崇光、南哲平、杉山栄二、豊岡利正、吉成浩一、轟木堅一郎
- Organizer
  新アミノ酸分析研究会第9回学術講演会
- Data Source
  KAKENHI-PROJECT-19K07028
[Presentation] 薬物のシトクロムP450反応性と肝障害誘発性の関連性解析2019
- Author(s)
  米川恵理、山崎弘量、清水佑記、佐々木崇光、渡邉美智子、志津怜太、保坂卓臣、竹下潤一、吉成浩一
- Organizer
  第46回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-17K08419
[Presentation] Interaction with YAP is a possible underlying mechanism for CAR-dependent hepatocarcinogenesis2019
- Author(s)
  Ryota Shizu, Taiki Abe, Keiichiro Sobe, Mai Ishimura, Takuomi Hosaka, Takamitsu Sasakim Kouichi Yoshinari
- Organizer
  The 12th International Meeting of the International Society for the Study of Xenobiotics
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08418
[Presentation] 薬物のシトクロムP450反応性に着目した薬剤性肝障害評価2018
- Author(s)
  米川恵理、清水佑記、佐々木崇光、渡邉美智子、志津怜太、保坂卓臣、竹下潤一、吉成浩一
- Organizer
  平成30年度内外環境応答・代謝酵素研究会（鳥取）
- Data Source
  KAKENHI-PROJECT-17K08419
[Presentation] 核内受容体CARおよびPXRによる肝細胞増殖調節におけるYAPの関与2018
- Author(s)
  石村麻衣、天池優斗、阿部太紀、志津怜太、保坂卓臣、佐々木崇光、吉成浩一
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-17K08418
[Presentation] Imazalil activates the nuclear receptor PXR to accelerate CAR-mediated hepatocyte proliferation in mice.2018
- Author(s)
  Shohei Yoshimaru, Ryota Shizu, Satoshi Tsuruta, Yuto Amaike, Makoto Kano, Takuomi Hosaka, Takamitsu Sasaki, Kouichi Yoshinari
- Organizer
  The 8th international congress of Asian Society of Toxicology (ASIATOX)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08418
[Presentation] 核内受容体 CAR の活性化が PPARα 依存的な脂質代謝調節に及ぼす影響2018
- Author(s)
  江崎香奈子、志津怜太、大塚祐多、石井千鶴、保坂卓臣、佐々木崇光、吉成浩一
- Organizer
  日本薬学会第138年会（金沢）
- Data Source
  KAKENHI-PROJECT-17K08419
[Presentation] 核内受容体CARおよびPXRによる肝細胞増殖調節におけるYAPの関与2018
- Author(s)
  石村麻衣、天池優斗、阿部太紀、志津怜太、保坂卓臣、佐々木崇光、吉成浩一
- Organizer
  日本薬学会第138年会（金沢）
- Data Source
  KAKENHI-PROJECT-17K08419
[Presentation] シトクロムP450反応性を利用した肝障害誘発性薬物の判別2018
- Author(s)
  米川恵理、清水佑記、佐々木崇光、渡邉美智子、志津怜太、保坂卓臣、竹下潤一、吉成浩一
- Organizer
  第45回日本毒性学会学術年会（大阪）
- Data Source
  KAKENHI-PROJECT-17K08419
[Presentation] Acceleration of murine hepatocyte proliferation by imazaril through the activation of nuclear receptor PXR2018
- Author(s)
  Shohei Yoshimaru, Ryota Shizu, Satoshi Tsuruta, Yuto Amaike, Makoto Kano, Takuomi Hosaka, Takamitsu Sasaki, Kouichi Yoshinari
- Organizer
  The 22nd North American Meeting of the International Society for the Study of Xenobiotics
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08418
[Presentation] A possible involvement of transcriptional coactivators in the inflammation-dependent downregulation of PXR-mediated CYP3A induction.2018
- Author(s)
  Maya Okamura, Ryota Shizu, Takuomi Hosaka, Takamitsu Sasaki, Kouichi Yoshinari
- Organizer
  2018 International Meeting on 22nd Microsomal Drug Oxidation and 33rd Japanese Society for the Study of Xenobiotics
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08418
[Presentation] 網羅的な化学物質のシトクロムP450阻害活性評価2018
- Author(s)
  佐々木崇光、渡邉美智子、川野拓歩、猿橋ひとみ、小倉瑠衣、志津怜太、保坂卓臣、吉成浩一
- Organizer
  平成30年度内外環境応答・代謝酵素研究会（鳥取）
- Data Source
  KAKENHI-PROJECT-17K08419
[Presentation] インビボ毒性試験データを用いた核内受容体PXRおよびCARの新規機能の探索2017
- Author(s)
  橘内陽子、竹下潤一、佐々木崇光、保坂卓臣、吉成浩一
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-25460195
[Presentation] ラットにおける肝化学発がんと核内受容体活性化の関連性2017
- Author(s)
  田部美紗子、志津怜太、保坂卓臣、佐々木崇光、吉成浩一
- Organizer
  フォーラム2017衛生薬学・環境トキシコロジー（仙台）
- Data Source
  KAKENHI-PROJECT-17K08419
[Presentation] 核内受容体CAR依存的な肝細胞増殖のインビトロ評価系の構築と分子機序の解明2017
- Author(s)
  天池優斗、阿部太紀、保坂卓臣、佐々木崇光、松沢厚、吉成浩一
- Organizer
  第44回日本毒性学会学術年会（横浜）
- Data Source
  KAKENHI-PROJECT-17K08419
[Presentation] CYP26A1遺伝子レポーターを用いたアゾール系化合物によるレチノイン酸の濃度変動の測定2017
- Author(s)
  進藤佐和子、塩谷安奈里、渡辺美智子、佐々木崇光、熊谷健、永田清
- Organizer
  第44回日本毒性学会学術年会（横浜）
- Data Source
  KAKENHI-PROJECT-17K08419
[Presentation] 核内受容体CARを介した肝細胞増殖のインビトロ評価系の構築と機序解析2017
- Author(s)
  吉成浩一、阿部太紀、天池優斗、志津怜太、保坂卓臣、佐々木崇光
- Organizer
  第24回肝細胞研究会
- Data Source
  KAKENHI-PROJECT-17K08418
[Presentation] ラットにおける肝化学発がんと核内受容体活性化の関連性2017
- Author(s)
  田部美紗子、志津怜太、保坂卓臣、鶴田聡志、志津怜太、佐々木崇光、吉成浩一
- Organizer
  平成29年度内外環境応答・代謝酵素研究会（福岡）
- Data Source
  KAKENHI-PROJECT-17K08419
[Presentation] 肝臓と腸管におけるCYP3A4誘導プロファイルの異同解明2017
- Author(s)
  鶴田聡志、保坂卓臣、志津怜太、佐々木崇光、吉成浩一
- Organizer
  第63回日本薬学会東海支部大会（岐阜）
- Data Source
  KAKENHI-PROJECT-17K08419
[Presentation] 化学物質のヒトP450阻害活性とその肝障害発症との関連性2017
- Author(s)
  佐々木崇光、渡邉美智子、清水佑記、櫛田まどか、隠岐仁美、竹下潤一、保坂卓臣、吉成浩一
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-25460195
[Presentation] シトクロムP450反応性評価の肝毒性予測への応用2017
- Author(s)
  佐々木崇光
- Organizer
  日本薬物動態学会第32回年会（東京）
- Invited
- Data Source
  KAKENHI-PROJECT-17K08419
[Presentation] A possible role of NF-kB in the anti-inflammatory effects of activated PXR2017
- Author(s)
  Maya Okamura, Taiki Abe, Satoshi Tsuruta, Ryota Shizu, Takuomi Hosaka, Takamitsu Sasaki, Susumu Kodama, Kouichi Yoshinari
- Organizer
  フォーラム2017衛生薬学・環境トキシコロジー（仙台）
- Data Source
  KAKENHI-PROJECT-17K08419
[Presentation] 薬剤性肝障害時の核内受容体 PXR の抗炎症作用における NF-κB の役割2017
- Author(s)
  岡村麻絢、阿部太紀、鶴田聡志、志津怜太、保坂卓臣、佐々木崇光、吉成浩一
- Organizer
  第24回日本免疫毒性学会学術年会（青森）
- Data Source
  KAKENHI-PROJECT-17K08419
[Presentation] Influence of food additives on nuclear receptor PXR2017
- Author(s)
  吉丸祥平、志津怜太、保坂卓臣、佐々木崇光、吉成浩一
- Organizer
  第22回静岡健康・長寿学術フォーラム（静岡）
- Data Source
  KAKENHI-PROJECT-17K08419
[Presentation] PXRの活性化による抗炎症作用の機序解析2017
- Author(s)
  岡村麻絢、阿部太紀、鶴田聡志、保坂卓臣、佐々木崇光、児玉進、吉成浩一
- Organizer
  第44回日本毒性学会学術年会（横浜）
- Data Source
  KAKENHI-PROJECT-17K08419
[Presentation] オボムコイドカラムを用いる光学活性医薬品肝代謝物の高感度LC-MS/MS分析2017
- Author(s)
  工藤悠翔，中村美鈴，轟木堅一郎，佐々木崇光，清水佑記，和田圭右，大槻秀幸，水野初，閔俊哲，吉成浩一，豊岡利正
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-25460195
[Presentation] 結合DNA配列の相違がPXR依存的転写活性化に及ぼす影響2017
- Author(s)
  保坂卓臣、山崎悠里子、曽田勇介、佐々木崇光、吉成浩一
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-25460195
[Presentation] 肝障害誘発性薬物の化学構造的特徴の解析2017
- Author(s)
  清水佑記、佐々木崇光、渡邉美智子、保坂卓臣、竹下潤一、吉成浩一
- Organizer
  第44回日本毒性学会学術年会（横浜）
- Data Source
  KAKENHI-PROJECT-17K08419
[Presentation] CYP3A4遺伝子の新規転写活性化について2017
- Author(s)
  渡辺考樹、小田桐玲王、荒津祐輔、佐々木崇光、進藤佐和子、熊谷健、永田清
- Organizer
  フォーラム2017衛生薬学・環境トキシコロジー（仙台）
- Data Source
  KAKENHI-PROJECT-17K08419
[Presentation] レチノイン酸の低濃度測定可能なCYP26A1遺伝子レポーターアッセイ系の構築2017
- Author(s)
  森謙太、鈴木裕之、塩谷安奈里、佐々木崇光、進藤佐和子、熊谷健、永田清
- Organizer
  フォーラム2017衛生薬学・環境トキシコロジー（仙台）
- Data Source
  KAKENHI-PROJECT-17K08419
[Presentation] Application of cytochrome P450 reactivity assessment to the prediction of livertoxicity of pesticides2017
- Author(s)
  川野拓歩、渡邉美智子、佐々木崇光、隠岐仁美、清水佑記、竹下潤一、志津怜太、保坂卓臣、吉成浩一
- Organizer
  第22回静岡健康・長寿学術フォーラム（静岡）
- Data Source
  KAKENHI-PROJECT-17K08419
[Presentation] Influence of food additives on nuclear receptor PXR2017
- Author(s)
  吉丸祥平、志津怜太、保坂卓臣、佐々木崇光、吉成浩一
- Organizer
  第22回静岡健康・長寿学術フォーラム
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08418
[Presentation] SREBP-2によるCYP3A4の転写制御2017
- Author(s)
  宮嵜靖之、保坂卓臣、志津怜太、佐々木崇光、吉成浩一
- Organizer
  日本薬物動態学会第32回年会（東京）
- Data Source
  KAKENHI-PROJECT-17K08419
[Presentation] 肝毒性予測を指向したシトクロムP450反応性評価による化学物質プロファイリング2017
- Author(s)
  佐々木崇光、渡邉美智子、清水佑記、櫛田まどか、隠岐仁美、竹下潤一、保坂卓臣、吉成浩一
- Organizer
  第24回HAB研究機構学術年会（東京）
- Data Source
  KAKENHI-PROJECT-17K08419
[Presentation] 核内受容体PXRの抗炎症作用におけるNF-κBの寄与の解析2017
- Author(s)
  岡村麻絢、阿部太紀、鶴田聡志、志津怜太、保坂卓臣、佐々木崇光、児玉進、吉成浩一
- Organizer
  フォーラム2017衛生薬学・環境トキシコロジー（仙台）
- Data Source
  KAKENHI-PROJECT-17K08419
[Presentation] 化学物質のP450反応性と反復投与毒性の関連性2017
- Author(s)
  渡邉美智子、佐々木崇光、清水佑記、櫛田まどか、隠岐仁美、竹下潤一、志津怜太、保坂卓臣、吉成浩一
- Organizer
  第63回日本薬学会東海支部大会（岐阜）
- Data Source
  KAKENHI-PROJECT-17K08419
[Presentation] 核内受容体CAR依存的な肝細胞増殖へのYAPの関与2017
- Author(s)
  天池優斗、阿部太紀、志津怜太、保坂卓臣、佐々木崇光、松沢　厚、吉成浩一
- Organizer
  フォーラム2017衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-17K08418
[Presentation] コレステロールレベル調節因子SREBP-2によるCYP3A4の転写制御2017
- Author(s)
  宮嵜靖之、保坂卓臣、志津怜太、佐々木崇光、吉成浩一
- Organizer
  第63回日本薬学会東海支部大会（岐阜）
- Data Source
  KAKENHI-PROJECT-17K08419
[Presentation] 核内受容体CARを介した肝細胞増殖のインビトロ評価系の構築と機序解析2017
- Author(s)
  吉成浩一、阿部太紀、天池優斗、志津怜太、保坂卓臣、佐々木崇光
- Organizer
  第24回肝細胞研究会（旭川）
- Data Source
  KAKENHI-PROJECT-17K08419
[Presentation] 核内受容体CARおよびPXRによる肝細胞増殖調節におけるYAPの関与2017
- Author(s)
  鶴田聡志、保坂卓臣、志津怜太、佐々木崇光、吉成浩一
- Organizer
  日本薬物動態学会第32回年会（東京）
- Data Source
  KAKENHI-PROJECT-17K08419
[Presentation] PPARγはヒト腸管由来LS180細胞におけるCYP3A4誘導の新規制御因子である2017
- Author(s)
  保坂卓臣、鶴田聡志、志津怜太、佐々木崇光、吉成浩一
- Organizer
  平成29年度内外環境応答・代謝酵素研究会（福岡）
- Data Source
  KAKENHI-PROJECT-17K08419
[Presentation] Role of YAP in CAR-mediated proliferation of mouse hepatocytes2017
- Author(s)
  Yuto Amaike, Taiki Abe, Ryota Shizu, Takuomi Hosaka, Takamitsu Sasaki, Atsushi Matsuzawa, Kouichi Yoshinari
- Organizer
  フォーラム2017衛生薬学・環境トキシコロジー（仙台）
- Data Source
  KAKENHI-PROJECT-17K08419
[Presentation] CYP遺伝子発現作用に及ぼす健康食品の影響2017
- Author(s)
  渡邉夢実、熊谷健、佐々木崇光、永田清
- Organizer
  フォーラム2017衛生薬学・環境トキシコロジー（仙台）
- Data Source
  KAKENHI-PROJECT-17K08419
[Presentation] 核内受容体CAR依存的な肝細胞増殖へのYAPの関与2017
- Author(s)
  天池優斗、阿部太紀、志津怜太、保坂卓臣、佐々木崇光、松沢厚、吉成浩一
- Organizer
  フォーラム2017衛生薬学・環境トキシコロジー（仙台）
- Data Source
  KAKENHI-PROJECT-17K08419
[Presentation] 化学物質のヒトシトクロムP450阻害活性の網羅的評価2016
- Author(s)
  渡邉美智子、清水佑記、櫛田まどか、隠岐仁美、保坂卓臣、佐々木崇光、吉成浩一
- Organizer
  平成28年度内外環境応答・代謝酵素研究会
- Place of Presentation
  静岡
- Year and Date
  2016-09-17
- Data Source
  KAKENHI-PROJECT-25460195
[Presentation] 薬物代謝を考慮したPPARαレポーターアッセイ系の構築2016
- Author(s)
  若月綾乃、保坂卓臣、佐々木崇光、吉成浩一
- Organizer
  平成28年度内外環境応答・代謝酵素研究会
- Place of Presentation
  静岡
- Year and Date
  2016-09-17
- Data Source
  KAKENHI-PROJECT-25460195
[Presentation] CYP3A4遺伝子の基本的転写活性化に関わる新規シスエレメントの探索2016
- Author(s)
  小田桐玲生、佐々木崇光、熊谷健、永田清
- Organizer
  平成28年度内外環境応答・代謝酵素研究会
- Place of Presentation
  静岡
- Year and Date
  2016-09-17
- Data Source
  KAKENHI-PROJECT-25460195
[Presentation] 健康食品による薬物代謝P450活性阻害の網羅的評価2016
- Author(s)
  永田清、佐藤裕、熊谷健、佐々木崇光
- Organizer
  フォーラム2016衛生薬学・環境トキシコロジー
- Place of Presentation
  東京
- Year and Date
  2016-09-10
- Data Source
  KAKENHI-PROJECT-25460195
[Presentation] マウスPXRの新規活性化物質の探索2016
- Author(s)
  加納誠人、阿部太紀、保坂卓臣、佐々木崇光、吉成浩一
- Organizer
  平成28年度内外環境応答・代謝酵素研究会
- Place of Presentation
  静岡
- Year and Date
  2016-09-17
- Data Source
  KAKENHI-PROJECT-25460195
[Presentation] ヒト肝P450発現模倣細胞を利用した薬物代謝活性評価系の確立2016
- Author(s)
  佐々木崇光、佐藤裕、熊谷健、吉成浩一、永田清
- Organizer
  第23回HAB研究機構学術年会
- Place of Presentation
  つくば
- Year and Date
  2016-06-01
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460195
[Presentation] 環境汚染物質perfluorocarboxylic acids (PFCAs) によるマウス及びヒトCAR活性化作用2016
- Author(s)
  髙橋美玲、阿部太紀、小島弘幸、保坂卓臣、佐々木崇光、吉成浩一
- Organizer
  第43回日本毒性学会学術年会
- Place of Presentation
  名古屋
- Year and Date
  2016-06-29
- Data Source
  KAKENHI-PROJECT-25460195
[Presentation] CYP26A1レポーター遺伝子発現ウイルスを用いた低濃度下におけるレチノイン酸合成・代謝酵素活性阻害評価系の検討2016
- Author(s)
  塩谷安奈里、渡邊美智子、渡辺郁実、角田駿哉、若生俊也、佐々木崇光、熊谷健、永田清
- Organizer
  平成28年度内外環境応答・代謝酵素研究会
- Place of Presentation
  静岡
- Year and Date
  2016-09-17
- Data Source
  KAKENHI-PROJECT-25460195
[Presentation] 新規マウスPXR活性化物質のセルベーススクリーニング2016
- Author(s)
  清水佑記、渡邉美智子、土屋早希、加納誠人、保坂卓臣、佐々木崇光、吉成浩一
- Organizer
  日本薬物動態学会第31回年会
- Place of Presentation
  松本
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-25460195
[Presentation] PXR stimulates the growth factor-mediated hepatocyte proliferation by inhibiting FOXO-mediated transcription of cell cycle suppressor genes2016
- Author(s)
  Taiki Abe, Ryota Shizu, Satoshi Benoki, Miki Takahashi, Susumu Kodama, Masaaki Miyata, Hosaka Takuomi, Takamitsu Sasaki, Atsushi Matsuzawa, Kouichi Yoshinari
- Organizer
  11th International ISSX Meeting
- Place of Presentation
  Busan
- Year and Date
  2016-06-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460195
[Presentation] インビトロにおけるマウス肝細胞のCAR依存的な細胞増殖2016
- Author(s)
  天池優斗、阿部太紀、保坂卓臣、佐々木崇光、吉成浩一
- Organizer
  平成28年度内外環境応答・代謝酵素研究会
- Place of Presentation
  静岡
- Year and Date
  2016-09-17
- Data Source
  KAKENHI-PROJECT-25460195
[Presentation] ヒト肝細胞でのCYP3A4誘導予測におけるインシリコモデルとヒトPXRレポーターアッセイの比較2016
- Author(s)
  保坂卓臣、永井美香、佐々木崇光、今野芳浩、吉成浩一
- Organizer
  日本薬物動態学会第31回年会
- Place of Presentation
  松本
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-25460195
[Presentation] Environmental pollutants PFCAs are phenobarbital-like indirect human and mouse CAR activators2016
- Author(s)
  Mirei Takahashi, Taiki Abe, Hiroyuki Kojima, Takuomi Hosaka, Takamitsu Sasaki, Kouichi Yoshinari
- Organizer
  11th International ISSX Meeting
- Place of Presentation
  Busan
- Year and Date
  2016-06-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460195
[Presentation] マウスPXRの新規活性化物質の探索2016
- Author(s)
  加納誠人、阿部太紀、保坂卓臣、佐々木崇光、吉成浩一
- Organizer
  フォーラム2016衛生薬学・環境トキシコロジー
- Place of Presentation
  東京
- Year and Date
  2016-09-10
- Data Source
  KAKENHI-PROJECT-25460195
[Presentation] 肝障害性化学物質のヒトシトクロムP450阻害活性2016
- Author(s)
  渡邉美智子、清水佑記、櫛田まどか、隠岐仁美、竹下潤一、保坂卓臣、佐々木崇光、吉成浩一
- Organizer
  フォーラム2016衛生薬学・環境トキシコロジー
- Place of Presentation
  東京
- Year and Date
  2016-09-10
- Data Source
  KAKENHI-PROJECT-25460195
[Presentation] 分子記述子と階層的クラスタリングを利用したラット肝毒性のインシリコ予測の試み2016
- Author(s)
  吉成浩一、中山晴香、橘内陽子、隠岐仁美、保坂卓臣、佐々木崇光、竹下潤一
- Organizer
  第29回日本動物実験代替法学会
- Place of Presentation
  福岡
- Year and Date
  2016-11-16
- Data Source
  KAKENHI-PROJECT-25460195
[Presentation] オボムコイドカラムとLC-MS/MSを組み合せた光学活性医薬品の肝代謝物網羅的解析2016
- Author(s)
  工藤悠翔、中村美鈴、轟木健一郎、佐々木崇光、清水佑記、和田圭右、大槻秀幸、水野初、閔俊哲、吉成浩一、豊岡利正
- Organizer
  日本分析化学会年会第65年会
- Place of Presentation
  札幌
- Year and Date
  2016-09-14
- Data Source
  KAKENHI-PROJECT-25460195
[Presentation] New approach for the prediction of repeated-dose toxicity using in vitro and in silico methods in combination with in vivo toxicity database2016
- Author(s)
  Kouichi YOSHINARI, Hitomi OKI, Takamitsu Sasaki, Takuomi Hosaka, Jun-ichi TAKESHITA
- Organizer
  ICCA-LRI and NIHS Workshop
- Place of Presentation
  淡路島
- Year and Date
  2016-06-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460195
[Presentation] 核内受容体PXRと臓器サイズ制御シグナルHippo pathwayのクロストーク2016
- Author(s)
  阿部太紀、保坂卓臣、佐々木崇光、児玉進、松沢厚、吉成浩一
- Organizer
  第43回日本毒性学会学術年会
- Place of Presentation
  名古屋
- Year and Date
  2016-06-29
- Data Source
  KAKENHI-PROJECT-25460195
[Presentation] 薬物代謝酵素シトクロムP450阻害活性を指標とした化学物質の生物学的プロファイリング2016
- Author(s)
  渡邉美智子、清水佑記、櫛田まどか、隠岐仁美、竹下潤一、保坂卓臣、佐々木崇光、吉成浩一
- Organizer
  第29回日本動物実験代替法学会
- Place of Presentation
  福岡
- Year and Date
  2016-11-16
- Data Source
  KAKENHI-PROJECT-25460195
[Presentation] 腸管由来LS180細胞とヒト肝細胞におけるCYP3A4誘導の比較2016
- Author(s)
  鶴田聡志、保坂卓臣、佐々木崇光、吉成浩一
- Organizer
  平成28年度内外環境応答・代謝酵素研究会
- Place of Presentation
  静岡
- Year and Date
  2016-09-17
- Data Source
  KAKENHI-PROJECT-25460195
[Presentation] 多環芳香族炭化水素によるCYP2D6発現誘導機構の解析2016
- Author(s)
  稲見敬太、佐々木崇光、熊谷健、吉成浩一、永田清
- Organizer
  平成28年度内外環境応答・代謝酵素研究会
- Place of Presentation
  静岡
- Year and Date
  2016-09-17
- Data Source
  KAKENHI-PROJECT-25460195
[Presentation] Activation of p38 MAPK by clotrimazole enhances the transctiption of human MRP3 through a novel transcriptional element2016
- Author(s)
  Takamitsu Sasaki, Keita Inami, Takeshi Kumagai, Kouichi Yoshinari, Kiyoshi Nagata
- Organizer
  11th International ISSX Meeting
- Place of Presentation
  Busan
- Year and Date
  2016-06-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460195
[Presentation] ラット反復投与毒性試験データを用いた肝細胞肥大の毒性学的特徴の解明2016
- Author(s)
  増田茜、増田雅美、保坂卓臣、佐々木崇光、吉成浩一
- Organizer
  第43回日本毒性学会学術年会
- Place of Presentation
  名古屋
- Year and Date
  2016-06-29
- Data Source
  KAKENHI-PROJECT-25460195
[Presentation] 新規マウスPXR活性化物質の探索2016
- Author(s)
  加納誠人、阿部太紀、保坂卓臣、佐々木崇光、吉成浩一
- Organizer
  第43回日本毒性学会学術年会
- Place of Presentation
  名古屋
- Year and Date
  2016-06-29
- Data Source
  KAKENHI-PROJECT-25460195
[Presentation] レチノイン酸代謝酵素CYP26の活性阻害評価系構築2015
- Author(s)
  新井　悠、佐々木崇光、稲見敬太、佐藤　裕、熊谷　健、吉成浩一、永田　清
- Organizer
  第54回日本薬学会東北支部大会
- Place of Presentation
  岩手
- Year and Date
  2015-09-26
- Data Source
  KAKENHI-PROJECT-25460195
[Presentation] Profiles of immune cells and reproduction of immune-mediated drug-induced injury2015
- Author(s)
  Fujisaka Y, Kondo Y, Sasaki T, Kogure T, Inoue J, Nakagome Y, Wakui Y, Iwata T, Morosawa T, Umetu T, Suzuki H, Yamaguchi H, Mano N, Nagata K, Shimosegawa T
- Organizer
  American College of Gastroenterology 2015 annual scientific meeting
- Place of Presentation
  Honolulu
- Year and Date
  2015-10-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460195
[Presentation] Construction of cell evaluation systems that mimic the P450 activity in human hepatocytes2015
- Author(s)
  Sato Y, Sasaki T, Arai Y, Kumagai T, Nagata K
- Organizer
  30 th, JSSX annual meeting
- Place of Presentation
  Tokyo
- Year and Date
  2015-11-12
- Data Source
  KAKENHI-PROJECT-25460195
[Presentation] レポーター遺伝子導入細胞株を用いた健康食品によるCYP1A1/1A2誘導の網羅的評価2015
- Author(s)
  永田　清、佐々木崇光、熊谷　健
- Organizer
  フォーラム2015　衛生薬学・環境トキシコロジー
- Place of Presentation
  神戸
- Year and Date
  2015-09-17
- Data Source
  KAKENHI-PROJECT-25460195
[Presentation] Profiles of immune in peripheral blood and reproduction of immune-mediated drug-induced injury in vitro2015
- Author(s)
  Fujisaka Y, Kondo Y, Kogure T, Inoue J, Nakagome Y, Iwata T, Morosawa T, Umetu T, Suzuki H, Yamaguchi H, Sasaki T, Mano N, Nagata K, Shimosegawa T
- Organizer
  第19回日本肝臓学会
- Place of Presentation
  東京
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-25460195
[Presentation] 薬物代謝酵素発現細胞及び誘導評価細胞を用いた薬物性肝障害研究について2015
- Author(s)
  佐々木崇光、熊谷　健、永田　清
- Organizer
  第42回日本毒性学会学術年会
- Place of Presentation
  金沢
- Year and Date
  2015-06-29
- Invited
- Data Source
  KAKENHI-PROJECT-25460195
[Presentation] サイクリン依存性キナーゼ1(Cdk1)がCYP2D6及びCYP3A4遺伝子発現に及ぼす影響の解析2015
- Author(s)
  稲見敬太、佐々木崇光、中島菜月、小野　緑、熊谷　健、永田　清
- Organizer
  平成27年度内外環境応答・代謝酵素研究会
- Place of Presentation
  旭川
- Year and Date
  2015-07-18
- Data Source
  KAKENHI-PROJECT-25460195
[Presentation] 板藍根含有成分のCYP1A1/1A2遺伝子発現誘導に及ぼすPXRの影響2014
- Author(s)
  熊谷　健、清松孝行、佐々木崇光、永田　清
- Organizer
  創薬研究センターシンポジウム
- Place of Presentation
  東北薬科大学（宮城県仙台市）
- Year and Date
  2014-06-14
- Data Source
  KAKENHI-PROJECT-25460195
[Presentation] AhRを介さない多環芳香族炭化水素によるCYP誘導機構の解明2014
- Author(s)
  稲見敬太、佐々木崇光、菅野秀一、熊谷　健、永田　清
- Organizer
  創薬研究センターシンポジウム
- Place of Presentation
  東北薬科大学（宮城県仙台市）
- Year and Date
  2014-06-14
- Data Source
  KAKENHI-PROJECT-25460195
[Presentation] アデノウイルスを用いた新規CYP3A4活性阻害実験系の開発と健康食品による薬物代謝活性阻害評価2014
- Author(s)
  佐藤　裕、髙橋昌悟、佐々木崇光、熊谷　健、永田　清
- Organizer
  創薬研究センターシンポジウム
- Place of Presentation
  東北薬科大学（宮城県仙台市）
- Year and Date
  2014-06-14
- Data Source
  KAKENHI-PROJECT-25460195
[Presentation] Hepatic differentiation of human induced pluripotent stem cells by using factors involved in liverfunction and development2013
- Author(s)
  Sasaki T
- Organizer
  International Symposium for Neurosciences
- Place of Presentation
  仙台
- Year and Date
  2013-02-26
- Data Source
  KAKENHI-PROJECT-23790193
[Presentation] 多環芳香族炭化水素によるCYP2D6およびCYP3A4の発現調節機構の解析2013
- Author(s)
  稲見敬太、佐々木崇光、熊谷　健、菅野秀一、永田　清
- Organizer
  2013年度P450、UGT、SULT研究会
- Place of Presentation
  宮崎
- Data Source
  KAKENHI-PROJECT-25460195
[Presentation] MRP3遺伝子発現誘導に関与するMAPK経路の解析2013
- Author(s)
  稲見敬太、、佐々木崇光、沼田喜弘、船越広大、新井　悠、菅野秀一、熊谷　健、永田　清
- Organizer
  創薬研究センターシンポジウム
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-25460195
[Presentation] CYP3A4遺伝子発現誘導に及ぼす健康食品の影響2013
- Author(s)
  熊谷　健、中澤洋一、工藤裕太、齋藤雄大、竹屋里恵、笠原　彩、佐々木崇光、永田　清
- Organizer
  フォーラム2013衛生薬学・環境トキシコロジー
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-25460195
[Presentation] Pharmacokinetic function of hepatocyte-like cells differentiated from human iPS cells2013
- Author(s)
  Kondo Y, Iwao T, Ogihara R, Sasaki T, Nagata K, Kurose K, Horikawa T, Niwa T, Yamaori S, Ohmori S, Nakamura K, Matsunaga T
- Organizer
  28th JSSX annual meeting
- Place of Presentation
  Tokyo
- Data Source
  KAKENHI-PROJECT-25460195
[Presentation] CYP2D6活性阻害評価系の構築と健康食品の使用実態調査に基づいた薬物相互作用の解析2013
- Author(s)
  佐々木瞳、佐々木崇光、稲見敬太、熊谷　健、永田　清
- Organizer
  第23回日本医療薬学会年会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-25460195
[Presentation] 肝分化iPS細胞へのLETF同時導入によるCYP3A4発現影響2013
- Author(s)
  佐藤　裕、高橋昌悟、佐々木崇光、松永民秀、永田　清
- Organizer
  2013年度P450、UGT、SULT研究会
- Place of Presentation
  宮崎
- Data Source
  KAKENHI-PROJECT-25460195
[Presentation] 健康食品である板藍根のCYP3A4発現誘導に及ぼす影響2013
- Author(s)
  熊谷　健、菅原亮輔、三浦真知、佐々木崇光、宮入伸一、永田　清
- Organizer
  創薬研究センターシンポジウム
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-25460195
[Presentation] 新規P450活性阻害実験系の開発と健康食品による薬物代謝活性阻害評価2013
- Author(s)
  佐藤　裕、髙橋昌悟、石橋幸奈、根本あゆみ、齋藤詩奈子、角間元美、榊　聡美、伏見　彩、佐々木崇光、熊谷　健、永田　清
- Organizer
  フォーラム2013衛生薬学・環境トキシコロジー
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-25460195
[Presentation] Hepatic differentiation of human induced pluripotent stem cells by using factors involved in liver function and development2013
- Author(s)
  Takamitsu Sasaki
- Organizer
  International Symposium for Neurosciences
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-23790193
[Presentation] Identification of a novel transactivation region of the MRP3 gene2012
- Author(s)
  Sasaki T, Numata Y, Narita M, Matsui S, Toriyabe T, Yamazoe Y, Nagata K
- Organizer
  International Symposium on PPF Molecular Pharmacokinetics
- Place of Presentation
  一橋記念講堂（東京都）
- Data Source
  KAKENHI-PROJECT-23790193
[Presentation] MicroRNA enhances the expression of CYP genes in HepG2 cells and hepatocyte-like cells differentiatedfromhumaninducedpluripotentstemcells2012
- Author(s)
  Sasaki T
- Organizer
  27 th, JSSX annual meeting
- Place of Presentation
  千葉
- Data Source
  KAKENHI-PROJECT-23790193
[Presentation] 肝特異的転写因子 HNF-6 による薬物代謝酵素発現誘導:新規薬物代謝研究ツールを志向した肝分化 iPS 細胞樹立への応用2012
- Author(s)
  佐々木崇光
- Organizer
  第1回東北薬科大学創薬研究センターシンポジウム
- Place of Presentation
  仙台
- Year and Date
  2012-05-19
- Data Source
  KAKENHI-PROJECT-23790193
[Presentation] Identification of a novel transactivation region of the MRP3 gene2012
- Author(s)
  Sasaki T
- Organizer
  International Symposium on PPF Molecular Pharmacokinetics
- Place of Presentation
  東京
- Year and Date
  2012-01-17
- Data Source
  KAKENHI-PROJECT-23790193
[Presentation] MicroRNA enhances the expression of CYP genes in HepG2 cells and hepatocyte-like cells differentiated from human induced pluripotent stem cells2012
- Author(s)
  Takamitsu Sasaki
- Organizer
  27 th, JSSX annual meeting
- Place of Presentation
  千葉
- Data Source
  KAKENHI-PROJECT-23790193
[Presentation] 肝特異的転写因子HNF-6による薬物代謝酵素発現誘導：新規薬物代謝研究ツールを志向した肝分化iPS細胞樹立への応用2012
- Author(s)
  佐々木崇光
- Organizer
  第1回東北薬科大学創薬研究センターシンポジウム
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-23790193
[Presentation] Hepatocyte nuclear factor-6 enhances expression of CYP3A4 in HepG2 cells and hepatocyte-like cells differentiated from human induced pluripotent stem cells2011
- Author(s)
  Sasaki T, Tanaka Y, Takahashi S, Kumagai T, Sakaguchi S, Matsunaga T, Nagata K
- Organizer
  日本薬物動態学会第26回年会
- Place of Presentation
  広島国際会議場（広島市）
- Data Source
  KAKENHI-PROJECT-23790193
[Presentation] Hepatocyte nuclear factor-6 enhances expression of CYP3A4 in HepG2 cells and hepatocyte-like cells differentiated from human induced pluripotent stem cells2011
- Author(s)
  Sasaki T
- Organizer
  26 th, JSSX annual meeting
- Place of Presentation
  広島
- Data Source
  KAKENHI-PROJECT-23790193
[Presentation] 板藍根によるCYP3A4活性誘導の検討2011
- Author(s)
  菅原亮輔、熊谷健、三浦真知、高橋昌悟、佐々木崇光、坂口修平、宮入伸一、永田清
- Organizer
  第50回日本薬学会東北支部大会
- Place of Presentation
  東北薬科大学（仙台市）
- Data Source
  KAKENHI-PROJECT-23790193
[Presentation] 凍結P450発現アデノウイルス感染細胞を用いた薬物代謝評価系の構築2011
- Author(s)
  安藤寛美、佐藤裕、高橋昌悟、佐々木崇光、永田清
- Organizer
  第50回日本薬学会東北支部大会
- Place of Presentation
  東北薬科大学（仙台市）
- Data Source
  KAKENHI-PROJECT-23790193
[Presentation] iPS細胞を用いた肝分化誘導法の検討2011
- Author(s)
  山田健太、佐々木崇光、高橋昌悟、松永民秀、永田清
- Organizer
  第50回日本薬学会東北支部大会
- Place of Presentation
  東北薬科大学（仙台市）
- Data Source
  KAKENHI-PROJECT-23790193
[Presentation] Indirubin, a compornent of Ban-Lan-Gen, activates CYP3A4 gene transcription through human pregnane X receptor2011
- Author(s)
  Kumagai T, Sugawara R, Miura M, Sasaki T, Miyairi S, Nagata K
- Organizer
  日本薬物動態学会第26回年会
- Place of Presentation
  広島国際会議場（広島市）
- Data Source
  KAKENHI-PROJECT-23790193
[Presentation] チオプリンS-メチルトランスフェラーゼ(TPMT)における発現調節因子の解析2009
- Author(s)
  佐々木崇光
- Organizer
  第4回東北薬科大学ハイテク・リサーチ・シンポジウム
- Place of Presentation
  仙台
- Year and Date
  2009-05-29
- Data Source
  KAKENHI-PROJECT-20790142
[Presentation] チオプリンS-メチルトランスフェラーゼ(TPMT)遺伝子多型によるバリアント酵素の機能解析2009
- Author(s)
  佐々木崇光
- Organizer
  第4回東北薬科大学ハイテク・リサーチ・シンポジウム
- Place of Presentation
  仙台
- Year and Date
  2009-05-29
- Data Source
  KAKENHI-PROJECT-20790142
[Presentation] A novel evaluation system for inhibition of CYP3A4 activity by dietary supplements.
- Author(s)
  Sato Y, Takahashi S, Sasaki T, Kumagai T, Nagata K
- Organizer
  19th North American ISSX Meeting and 29th JSSX Meeting
- Place of Presentation
  San Francisco (USA)
- Year and Date
  2014-10-19 – 2014-10-23
- Data Source
  KAKENHI-PROJECT-25460195
[Presentation] Cyclin-dependent kinase 1 involved in regulation of CYP2D6 expression.
- Author(s)
  Inami K, Sasaki T, Kanno S, Kumagai T, Nagata K
- Organizer
  19th North American ISSX Meeting and 29th JSSX Meeting
- Place of Presentation
  San Francisco (USA)
- Year and Date
  2014-10-19 – 2014-10-23
- Data Source
  KAKENHI-PROJECT-25460195
[Presentation] Effect of Ban-Lan-Gen on transactivation of the CYP1A1 and CYP1A2 genes A novel evaluation system for inhibition of CYP3A4 activity by dietary supplements
- Author(s)
  Kumagai T, Kiyomatsu T , Sasaki T, Nagata K
- Organizer
  19th North American ISSX Meeting and 29th JSSX Meeting
- Place of Presentation
  San Francisco (USA)
- Year and Date
  2014-10-19 – 2014-10-23
- Data Source
  KAKENHI-PROJECT-25460195

1. HIRATSUKA Masahiro (50282140)

# of Collaborated Projects: 3 results

# of Collaborated Products: 6 results
2. Yoshinari Kouichi (60343399)

# of Collaborated Projects: 3 results

# of Collaborated Products: 46 results
3. Hosaka Takuomi (30611579)

# of Collaborated Projects: 3 results

# of Collaborated Products: 44 results
4. 志津怜太 (50803912)

# of Collaborated Projects: 3 results

# of Collaborated Products: 40 results
5. KONNO Yumiko (90364413)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. 永田清 (80189133)

# of Collaborated Projects: 2 results

# of Collaborated Products: 40 results
7. MIZUGAKI Michinao (60004595)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. Mizuno Hajime (30457288)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
9. 松沢厚

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Sasaki Takamitsu 佐々木 崇光

SASAKI Takamitsu 佐々木 崇光

Research Projects

Research Products

Co-Researchers

Development of mitochondrial mass spectrometry in live single-cell.

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Elucidation of the molecular mechanism of CYP3A4 induction in the human intestine and its differences from the liver

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Nuclear receptor PXR-mediated hepatocyte proliferation: understanding of its mechanism and human relevance

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Development of evaluation methods for drug-induced liver injury based on both chemical structure/biological reactivity of drugs and individual factorsPrincipal Investigator

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Development of a model for the monitoring ontogenic expression of CYP3A by used of secreted reporter-expressing iPS cellsPrincipal Investigator

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Efficient generation of functional hepatocytes from human induced pluripotent stem cells and isolation of hepatic progenitor cellsPrincipal Investigator

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Functional characterization of drug metabolizing enzyme genes and variant proteins

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Analysis of epigenetic regulation of drug-metabolizing enzymes catalyzing anticancer drugsPrincipal Investigator

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Analysis of genetic polymorphisms in human drug-metabolizing enzyme genes and functions of enzymatic proteins

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メルカプトプリン投与による肝障害とキサンチンオキシダーゼ(XO)遺伝子多型解析

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[Book] 創薬研究のストラテジー上2011

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[Book] 創薬研究のストラテジー上2011

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[Journal Article] Functional interaction between PXR and YAP in xenobiotic-dependent liver hypertrophy and drug metabolism.2019

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[Journal Article] Possible involvement of the competition for the transcriptional coactivator glucocorticoid receptor-interacting protein 1 in the inflammatory signal-dependent suppression of PXR-mediated CYP3A induction in?vitro2019

Author(s)

Sasaki Takamitsu 佐々木崇光

SASAKI Takamitsu 佐々木崇光