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MIZUGAKI Michinao  水柿 道直

ORCIDConnect your ORCID iD *help
… Alternative Names

水柿 通直

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Researcher Number 60004595
Other IDs
External Links
Affiliation (based on the past Project Information) *help 2006: Tohoku Pharmaceutical University, Clinical Pharmaceutics, Professor, 薬学部, 特任教授
2005: 東北薬科大学, 薬学部, 教授
2002: Tohoku Pharmaceutical University, Professor, 薬学部, 教授
1997 – 2001: Tohoku University, Hospital, Professor, 医学部・附属病院, 教授
1996 – 1997: 東北大学, 医学部, 教授 … More
1996: 東北大学, 医学部附属病院, 教授
1995: Tohoku University Hospital, Phamaceatical Sciences, Professor, 医学部附属病院・薬剤部, 教授
1993 – 1995: Tohoku University School of Medicine, Department of Pharmacy, Professor, 医学部・附属病院, 教授
1994: 東北大学, 医学部附属病院, 教授
1993: 東北大学医学部附属病院, 薬剤部, 教授
1990 – 1992: 東北大学, 医学部附属病院, 教授
1991: 東北大学, 附属病院, 教授
1988 – 1989: Tohoku University Hospital, 医学部付属病院, 教授
1988: 東北大学, 医学部・付属病院薬剤部, 教授
1987: 東北大学, 医学部, 教授
1987: 東北大学, 医学部・薬剤部, 教授
1987: 東北大学, 医学部附属病院薬剤部, 教授
1986 – 1987: 東北大学, 医学部附属病院, 教授
1986: 東北大, 医学部, 教授 Less
Review Section/Research Field
Principal Investigator
Psychiatric science / 応用薬理学・医療系薬学 / Medical pharmacy / Radiation science
Except Principal Investigator
応用薬理学・医療系薬学 / Respiratory organ internal medicine / Circulatory organs internal medicine / Bioorganic chemistry / Cerebral neurosurgery
Keywords
Principal Investigator
エイコサペンタエン酸 / GC / MS / プロスタグランジン / PGI_3 / プロスタサイクリン / 修飾ヌクレオシド / 1-メチルアデノシン / シュードウリジン / モニタリング … More / 体内動態 / CYP2D6 / SNP / Denaturing HPLC / GC@SIM / モノクロ-ナル抗体 / △^<17>-6keto-PGF_<1α> / △ ^<17>ー6ーketoーPGF_<1a> / TXB_3 / Δ^<17>-6-keto-PGF_<1α> / 糖尿病 / 3型PG / DELTA^<17>-2,3-dinor-6-keto PGF_<1α> / 阻害ELISA / 固型腫瘍 / 診断 / 予後判定 / 腫瘍マーカー / コカイン / 麻薬 / ポジトロン / 中毒 / 逆耐性 / cocaine / drug / positron / addiction / biodistribution / sensitization / ロイコトリエン / シクロオキシゲナーゼ / トロンボキサン / 炎症 / 病態 / 血小板活性化因子 / 測定法 / イムノアッセイ / リポキシゲナーゼ / prostaglandin / thromboxane / cyclooxygenase (COX) / 8-isoprostane / leukotriene (LT) / LC-MS / 11beta-PGF_<2alpha> / LTB_4 / 遺伝子多型 / ファルマコジェネティクス / Genetic polymorphism / Pharmacogenetics / ポジトロン標識薬剤の合成 / 11C標識イミプラミン / 11C標識メタンフェタミン / 体内分布 / 脳内分布 / レセプター / 【^(11)C】標識イミプラミン / 【^(11)C】標識メタンフェタミン / syhthesis of ^<11>C-labelled drug / ^<11>C-imipramine / ^<11>C-methamphetamine tissue distribution / regional distribution in brain … More
Except Principal Investigator
GC / GC-MS / モノクローナル抗体 / MS / エイコサペンタエン酸 / ファージディスプレイ / プロスタサイクリン / トロンボキサン / SIM / ECNICIMS / PFB / BDMS / ELISA / PET / プロスタグランジン / Δ^<17>-6-keto-PGF^<1d> / モノクロ-ナル抗体 / マウスモノクローナル抗体 / シュードウリジン / CDRペプチド / 非アドレナリン作動性抑制神経 / Cー線継続末 / カプサイシン / 刺激受容体 / 即時裂アレルギー反応 / VIP / 交感神経 / 気管支平滑筋 / C-fiber受容体 / irritant受容体 / 神経伝達物質 / アルツハイマー病 / 血管性痴呆 / 脳萎縮 / 老年期痴呆 / 11-デヒドロ-トロンボキサンB2 / 2,3-ジノル-6-ケト-PGF1α / 測定法 / 高血圧 / 妊娠中毒症 / 炎症 / トロンボキサン(TXA_2) / プロスタサイクリン(PGI_2) / 11-dehydro-TXB_2 / 2,3-dinor-b-keto PGF_1α / 6,15-diketo-13,14dehydro PGF_1α / RIA法 / EIA法 / 2,3-dinor 6-keto PGF_1α / 6,15-diketo-13,14 dihydro PGF_1α / Prostacyclin / Thromboxane A_2 / 11-dehydro-thromboxane B_2 / 2, 3-dinor-6-keto-prostaglandin F_1alpha / Hypertension / Toxemia of pregnancy / Inflammation / Measurement / GC-SIM / 3型プロスタグランジン / 糖尿病 / 11-dehydro-TXB_3 / 6,15-diketo-13,14-dihydro-PGF_<1α> / 阻害ELISA / 3型PG / prostaglandin / prostacycline / thromboxane / 11-dehydro-TXB2 / 11-dehydro-TXB3 / biodistribution / 20 HETE / 19 HETE / グルクロン酸抱合 / 20-HETE / 19-HETE / PFB-tert-BDMS誘導体 / 20HETE / 19HETE / glucuronide conjugate / ヒト型抗体 / コンビナトリアルライブラリー / ロタウイルス / ファージディスプレイシステム / Phage display system / Human antibodies / Combinatorial libraries / Rotaviruses / シガトキシン / 抗体 / ハプテン / 抗原 / 遺伝子配列 / 合成 / オレフィンメタセシス / 人工抗原 / シガテラ / 抗シガトキシン抗体 / 海産ポリエーテル / コンジュゲート / 免疫 / ciguatoxin / antibody / hapten / antigen / gene / synthesis / olefin metathesis / メタンフェタミン / 逆耐性 / ヒスタミン / EphA5受容体 / 画像解析 / 麻酔 / 覚醒剤 / 覚醒剤精神病 / ドパミン / 脳 / MAP / DNAメチル化 / ガングリオシド / ヒト / サル / 受容体 / methamphetamine / sensitization / Histamine / EphA5 / imaging / anesthesia / イノシトールリン脂質 / 脳虚血 / 〔^3H〕-inositol / シナプトゾーム / ブレインスライス / 虚血脳 / 可逆性 / 脂質代謝 / inositol phospholipid Less
  • Research Projects

    (22 results)
  • Co-Researchers

    (36 People)
  •  Analysis of genetic polymorphisms in human drug-metabolizing enzyme genes and functions of enzymatic proteinsPrincipal Investigator

    • Principal Investigator
      MIZUGAKI Michinao
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Medical pharmacy
    • Research Institution
      Tohoku Pharmaceutical University
  •  Investigation of mechanism of stimulant-induced psychosis -Imaging study by PET -Principal Investigator

    • Principal Investigator
      HISHINUMA Takanori, 水柿 道直
    • Project Period (FY)
      2000 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      応用薬理学・医療系薬学
    • Research Institution
      TOHOKU UNIVERSITY
  •  A Study on Designed Hapten Aimed at Anti-ciguatoxin Monoclonal Antibody

    • Principal Investigator
      HIRAMA Masahiro
    • Project Period (FY)
      1998 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (B).
    • Research Field
      Bioorganic chemistry
    • Research Institution
      Tohoku University
  •  抗体のCDR領域に由来する機能性ペプチド分子の作製とがん治療への応用

    • Principal Investigator
      ITOH Kunihiko
    • Project Period (FY)
      1997
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Akita University
  •  Preparation and Clinical application of Human Monoclonal Antibodies using Phage Display System.

    • Principal Investigator
      ITOH Kunihiko
    • Project Period (FY)
      1996 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      応用薬理学・医療系薬学
    • Research Institution
      Akita University
  •  尿中トメチルアデノシンとシュードウリジンの固形腫瘍の予後判定への応用Principal Investigator

    • Principal Investigator
      水柿 道直
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tohoku University
  •  Arachibonate cascade and physiologicalPrincipal Investigator

    • Principal Investigator
      MIZUGAKI Michinao
    • Project Period (FY)
      1995 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      応用薬理学・医療系薬学
    • Research Institution
      Tohoku University
  •  尿中1-メチルアデノシンとシュードウリジンの固形腫瘍の予後判定への応用Principal Investigator

    • Principal Investigator
      水柿 道直
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tohoku University
  •  Development of HETE Analysis by means of mass Spectrometry

    • Principal Investigator
      OHYAMA Yoshiharu
    • Project Period (FY)
      1994 – 1995
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      応用薬理学・医療系薬学
    • Research Institution
      Tohoku University
  •  エイコサペンタエン酸誘導体の構造と栄養学的意義との関連性の検討Principal Investigator

    • Principal Investigator
      水柿 道直
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tohoku University
  •  Development of microdetermination of 3-series prostanoid and the study of the physiological significance in diseases

    • Principal Investigator
      HISHINUMA Takanori
    • Project Period (FY)
      1993 – 1994
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      応用薬理学・医療系薬学
    • Research Institution
      TOHOKU UNIVERSITY
  •  エイコサペンタエン酸誘導体の構造と栄養学的意義との関連性の検討Principal Investigator

    • Principal Investigator
      水柿 道直
    • Project Period (FY)
      1992
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tohoku University
  •  3型プロスタノイドの超微量定量を目的としたモノクローナル抗体の作製

    • Principal Investigator
      菱沼 隆則
    • Project Period (FY)
      1991 – 1992
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      応用薬理学・医療系薬学
    • Research Institution
      Tohoku University
  •  Standardization and problems to measure prostanoids in the biological fluid.

    • Principal Investigator
      ABE Keishi
    • Project Period (FY)
      1991 – 1993
    • Research Category
      Grant-in-Aid for Developmental Scientific Research (B)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      TOHOKU UNIVERSITY
  •  The study of the addiction using positron-labeled cocainePrincipal Investigator

    • Principal Investigator
      MIZUGAKI Michinao
    • Project Period (FY)
      1990 – 1991
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Psychiatric science
    • Research Institution
      Tohoku University
  •  エイコサペンタエン酸誘導体の構造と生物活性との相関(栄養学的意義の再検討)Principal Investigator

    • Principal Investigator
      水柿 道直
    • Project Period (FY)
      1989
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tohoku University
  •  エイコサペンタエン酸誘導体の構造と生物活性との相関(栄養学的意義の再検討)Principal Investigator

    • Principal Investigator
      水柿 道直
    • Project Period (FY)
      1988 – 1990
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tohoku University
  •  エイコサペンタエン酸誘導体の構造と生物活性との相関(栄養学的意義の再検討)Principal Investigator

    • Principal Investigator
      水柿 道直
    • Project Period (FY)
      1988
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tohoku University
  •  老人(老年期)痴呆の画像解析ーPET・MR-CT(MRI)・X-CTによる定量的計測を中心にー

    • Principal Investigator
      MATSUZAWA Taiju
    • Project Period (FY)
      1987
    • Research Category
      Grant-in-Aid for General Scientific Research (A)
    • Research Institution
      Tohoku University
  •  Inositol phospholipid metabolism in cerebral ischemia

    • Principal Investigator
      KATAKURA Ryuichi, 今泉 茂樹
    • Project Period (FY)
      1987 – 1988
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Cerebral neurosurgery
    • Research Institution
      TOHOKU UNIVERSITY
  •  未知の気道拡張性神経活性物質の検出および同定・合成に関する研究

    • Principal Investigator
      井上 洋西
    • Project Period (FY)
      1986 – 1988
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Respiratory organ internal medicine
    • Research Institution
      Tohoku University
  •  Synthesis and biodistribution of ^<11>C-imipramine and ^<11>C-methamphetaminePrincipal Investigator

    • Principal Investigator
      MIZUGAKI Michinao
    • Project Period (FY)
      1986 – 1987
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Radiation science
    • Research Institution
      TOHOKU UNIVERSITY
  • 1.  HISHINUMA Takanori (20199003)
    # of Collaborated Projects: 12 results
    # of Collaborated Products: 0 results
  • 2.  OHYAMA Yoshiharu (30233290)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 3.  EDO Kiyoto (40125505)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 4.  石橋 正兀
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 5.  YAMAMOTO Syuzo (50025607)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 6.  MUROTA Seiitsu (50072989)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 7.  OUTI Kazuo (20006357)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 8.  ITOH Kunihiko (90221770)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 9.  SUZUKI Toshio (20108559)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 10.  MATSUZAWA Taiju (10006108)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 11.  SATO Mitsumoto (70033321)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 12.  ABE Keishi (60004777)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 13.  KATORI Makoto (50050365)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 14.  KATAKURA Ryuichi (70152676)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 15.  SHIMIZU Takao (80127092)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  OMATA Ken (50194634)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  HIRAMA Masahiro (30165203)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  OGURI Hiroki (80311546)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  TOMIOKA Yoshihisa (00282062)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  YANAI Kazuhiko (50192787)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  ITO Masatoshi (00125501)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 22.  IDO Tatsuo (80134063)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 23.  NUMACHI Yotaro (00261636)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 24.  HIRATSUKA Masahiro (50282140)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 25.  KONNO Yumiko (90364413)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 26.  SASAKI Takamitsu (20382674)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 27.  ENDO Masao (40004668)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 28.  MOTOMIYA Masakichi (20006092)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 29.  井上 洋西 (40133962)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 30.  飛田 渉 (10142944)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 31.  無江 季次 (40004882)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 32.  石井 慶造 (00134065)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 33.  武田 俊平 (00006115)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 34.  小暮 久也 (20133936)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 35.  今泉 茂樹 (30160039)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 36.  石田 名香雄
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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