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Yanai Kazuhiko  谷内 一彦

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… Alternative Names

谷内 一彦  ヤナイ カズヒコ

YANAI Kazuhiko  谷内 一彦

矢内 一彦  ヤナイ カズヒコ

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Researcher Number 50192787
Other IDs
External Links
Affiliation (Current) 2022: 東北大学, 医学系研究科, 名誉教授
Affiliation (based on the past Project Information) *help 2022: 東北大学, 医学(系)研究科(研究院), 教授
2016 – 2020: 東北大学, 医学系研究科, 教授
2015: 東北大学, 大学院医学系研究科, 教授
2012 – 2015: 東北大学, 医学(系)研究科(研究院), 教授
2011: 東北大学, 医学系研究科, 教授 … More
2007 – 2011: Tohoku University, Graduate School of Medicine, Professor
2006: 東北大学, 大学院医学研究科, 教授
2006: Tohoku University, Graduate School of Medicine, Professor, 大学院医学系研究科, 教授
1999 – 2005: Sch. Of Med., Tohoku Univ., Prof., 大学院・医学系研究科, 教授
2001: 東北大学, 大学院・医学系研究科), 教授
1999: 東北大学, 大学院・医学系研究所, 教授
1998: TOHOKU UNIVERSITY SCHOOL OF MEDICINE,DEPARTMENT OF PHARAMACOLOGY,PROFESSOR, 医学部, 教授
1995 – 1997: Tohoku Univ, Sch. of Med. Assoc. Pro, 医学部, 助教授
1993 – 1994: 東北大学, 医学部, 講師 Less
Review Section/Research Field
Principal Investigator
Applied pharmacology / General pharmacology / General pharmacology / Neurochemistry/Neuropharmacology / 応用薬理学・医療系薬学 / Medium-sized Section 52:General internal medicine and related fields / Radiation science / Neurochemistry/Neuropharmacology / Biological Sciences / 老化(加齢) / Neuroscience in general / Basic Section 48030:Pharmacology-related … More
Except Principal Investigator
… More General pharmacology / Neurochemistry/Neuropharmacology / Biological Sciences / Radiation science / Radiation science / Science and Engineering / Engineering / General pharmacology / General internal medicine (including Psychosomatic medicine) / New fields of law / Psychiatric science / Ophthalmology / 応用薬理学・医療系薬学 / Neurochemistry/Neuropharmacology / Pain science Less
Keywords
Principal Investigator
PET / ヒスタミン / アルツハイマー病 / 分子イメージング / リガンド賦活法 / 抗ヒスタミン薬 / ノックアウトマウス / アセチルコリンエステラーゼ / 痛みの受容 / 神経変性疾患 … More / Histamine / 眠気 / H_2^<15>O / 脳賦活試験 / ヒスタミンH_1受容体 / Alzheimer disease / ヒスタミントランスポーター / 3次元データ収集PET / 脳賦活試験法 / ヒト / スーパーコンピューター / ストレス / 3次元PET / ヒスタミンH1受容体 / ヒスタミンH2受容体 / ダブルノックアウトマウス / ヒスタミンH4受容体 / ヒスタミン受容体 / PMAT / イメージング / トランスレーショナルリサーチ / autoradiography / ヒト脳 / ポジトロン / activation study / うつ病 / histamine / fluorine-18 / モルヒネ / ヒスタミンH-3受容体 / 脳 / 除神経 / 結合実験 / S-メチルチオペラマイド / ヒスタミンH_3受容体 / 受容体占拠率 / 認知機能障害 / 抗ヒスタミン / ^<11>C-ドキセピン / 受容体イメージング / 情動 / ^<11>C-標識薬剤 / 受容体 / 脳機能検査法 / ドパミン / ^<11>C(carbon-11) / ガス相法 / ヨウ化メチル / 脳血流測定法 / Human Brain Mapping / fMRI / Receptor / Neurotransmission / Imaging / 神経伝達物質遊離 / 自動車運転試験 / ブレーキ反応時間 / P-糖タンパク / 遺伝子多型 / 脳血液関門 / P糖タンパク / H_1受容体占拠率 / C11-ドネペジル / フェキソフェナジン / C11-ドキセ / 安全性基準 / 探索的臨床試験 / マイクロドーズ概念 / 産学連携 / 臨床研究の利益相反 / アミロイドAβ蛋白 / ヒスタミンH3受容体 / トリプルノックアウトマウス / 遺伝子型 / メンデルの法則 / 日内リズム / 多重ノックアウトマウス / ヒスチジン脱炭酸酵素(HDC) / 行動薬理学 / プロテオミクス / 性差 / small GTPase Rho / Rac / Dynamin / internalization / H3受容体 / H1受容体占拠率 / 膵ランゲルハンス島β細胞 / 分子イメニジング / 小動物用PET/CT / ヒト臨床研究 / 中枢神経系 / マイクロドーズ / 脳内薬物動態 / アミロイド・イメージング / タウ・イメージング / α-シヌクレイン・イメージング / マーモセット / 小動物用PET / 被ばく線量 / 小動物イメージング / 炭素１１ / フッ素１８ / 薬理学 / 放射線 / 脳・神経・脳神経疾患 / 老化 / 脳神経疾患 / 認知症 / ヒスタミン代謝酵素 / HNMT / 脳の老化 / 局所脳糖代謝率 / 老化促進マウス / ヒスタミンH-1受容体ノックアウトマウス / Histamine H1 receptor / Aging / human / brain / H3 receptor / 高次脳機能 / ヒスタミンH-1受容体 / イメージングプレート / オートラジオグラフィー / Brain function / HistamineH,Receptor / antihistamines / human brain / ^<18>F-標識ヨウ化フルオロベンジル / スーパーコンピュータ / ドパミンD_2受容体 / 脳賦治試験 / 3次元データ再構成法 / ヒスタミン神経系 / ドパミンD2受容体 / ヒスタミンH^1受容体 / 神経伝達 / 薬物受容体 / 3次元 / 3D-PET / Ligand activation / Human brain / gammaCBF / Carbon-11("C) / fluorine-18(^<18>F) / 脳機能検査 / 賦活研究 / Carbon-11(^<11>C) / carbon-11(^<11>C) / carbon-11(C^<11>) / fluorine-18(F^<18>) / H_2O^<15> / Radiopharmaceuticals / receptor occupancy / cognitive function / cerebral blood flow / ligand-activation study / carbon-11 / ポジトロンエミッショントモグラフィー(PET) / 薬効評価 / ^<11>C-ドネペジル / 脳機能賦活試験 / 痛みの受客 / けいれんキンドリング / アレキシサイミア / carbn-11 / ヒスタミンH_1,H_2受容体 / セロトニン / モルセネ / ^<11>C / Knockout mice / drug development / acetylcholine esterase / ^<11>C-donepezil / pain perception / オレキシン / アデノシン / 鎮痛作用 / 遺伝子ノックアウトマウス / 統合失調症 / 痛み / activity stress / 神経性食欲低下症 / ドキセピン / ハロペリドール / 覚醒 / 脳血流量 / Orexins / Adenosine / Pain perception / Antinocicention / gene knockout mice / Schizouhrenia / Positron Emission Tomography(PET) / トランスレーショナル・リサーチ / ヒスタミンH1受容体占拠率 / アミロイドAβ / Acetylcholinesterase / translational research / Molecular imaging / Positron Emission Tomography (PET) / Histamine 1-11 receptors / Antihistamines / amyloid Aβ proteins / 放射性医薬品 / タンパク質 / ミスフォールディング / グリオーシス / タンパク質プローブ / 神経疾患 / BBB透過性ペプチド … More
Except Principal Investigator
PET / ヒスタミン / ノックアウトマウス / ヒスチジン脱炭酸酵素 / H2受容体 / 放射性薬剤 / F-18 / Histamine / H1受容体 / ヒスタミンH1受容体 / メタンフェタミン / アルツハイマー病 / ヒスタミンH3受容体 / Radiopharmaceutical / 神経可塑性 / トランスポーター / 半導体PET / 分子イメージング / 認知 / 老化 / アミロイドβ蛋白 / マイクロリアクター / 標識合成 / ストレス / フルオロデオキシグルコース(FDG) / 学習・記憶 / 痙攣 / Convulsion / ヒスタミンH_3受容体 / ヒスタミンN-メチル基転移酵素 / histamine / histidine decarboxylase / knockout mice / フルオロベンジルハライド / ポジトロン放出核種 / Fluorobenzyl halide / Fluorine-18 / Knock-out mice / 覚醒剤精神病 / GC-MS / 自動合成 / Automated synthesis / 化学的除神経 / 物理的除神経 / 6-ヒドロキシドーパ / 線状体 / NO / NOS / シナプトゾーム / イミプラミン / 自発運動 / ヒスタミン欠陥マウス / 陽電子断層撮影装置 / 放射線 / システム工学 / 医療・福祉 / 核医学 / CT / 半導体検出器 / 放射線計測 / 原子力学 / fMRI / 注意 / 感情 / フッ素-18 / 電気化学的濃縮 / 電気化学 / フッ素イオン / 炎症性発癌 / シメチジン / 骨髄由来抑制細胞 / アゾキシメタン / デキストラン硫酸ナトリウム / 炎症 / 発癌 / ヒスタミン受容体拮抗薬 / カイロプラクティック / ポジトロン断層法(PET) / 代替医療 / 局所脳活動 / 鍼灸治療 / 代替療法 / 局所脳糖代謝 / 医事法学 / 生命科学研究規制 / 研究支援制度 / 国際的研究規制 / 研究不正 / 科学研究規制 / アップ・レギュレーション / クローニング / NMDA受容体 / マイクロダイアリシス / 神経毒 / 初代培養 / Histamine H1 receptor / histamine H3 receptor / upregulation / microdialysis / neurotoxin / NMDA receptor / 加令 / Learning-Memory / Aging / 喘息 / 痴呆 / Histamine H3 receptor / Asthma / Dementia / ヒスタミンN-メチル基転位酵素 / H_3受容体 / ヒスタミン・トランスポーター / ヒスチジン脳炭酸酵素 / ヒスチジン・デカルボキシラーゼ / ヒスタミンN-メチルトランスフェラーゼ / histamine N-methyltranferase / HィイD23ィエD2 receptor / transporter / F^<18>-標識化合物 / 3次元PET / 神経受容体 / 脳賦活試験法 / リガンド賦活法 / 臨床研究 / ^<18>F-標識化合物 / スーパーコンピューター / 3次元データ再構成法 / ^<18>F-標識法 / ^<18>F-標識ヨウ化フルオロベンジル / ドパミンD2受容体 / 眠気 / ドパミンD_2受容体 / ヒスタミンH_1受容体 / Drug development / receptor occupancy / cognitive function / histamine H1 receptors / ligand activation study / carbon-11 / fluorine-18 / ヒスタミンレセプター / fluoroproxyfan / Histamine receptor / positron emitter / Fluoroproxyfan / Radioligand / ヒスチジン脱炭素酵素 / 遺伝子改変動物 / H_1受容体 / H_2受容体 / 脳機能 / H1 receptor / H2 receptor / Histidine decarboxylase / Brain functions / 精神分裂病 / 遺伝子多型 / 逆耐性現象 / Schizophrenia / Polymorphism / 標識合成前駆体 / ボジトロン放出核種 / 標識薬剤合成前駆体 / Labeling precursor / Positron emitter / H3受容体 / 視覚情報処理 / H3 receptor / Visual Processing / 逆耐性 / EphA5受容体 / 画像解析 / 麻酔 / 覚醒剤 / ドパミン / 脳 / MAP / DNAメチル化 / ガングリオシド / ヒト / サル / 受容体 / methamphetamine / sensitization / EphA5 / imaging / anesthesia / トランスジェニックマウス / 遺伝子 / 感染 / アレルギー / 行動 / 肥満細胞 / 胃酸分泌 / 概日リズム / SAGE法 / transgenic mice / gene / infection / allergy / behavior / ミニチュア合成装置 / マイクロリアクタ / 比放射能 / Miniaturized synthesis module / Microreactor / Labeling / 分子プローブ / フルオロメチル / radiopharmaceutical / Molecular probe / Fluoromethyl / ヒスタミン神経系 / マウス / 幼児期 / 非定型抗精神病薬 / 神経新生 / 大気マイクロPIXE / 記憶・学習 / 大気マイクロPUXE / histaminergic neuron system / mice / stress / childhood / learning / memory / atypical anti-psychotics / neurogeneses / in-air micro PIXE / 薬理学 / 疼痛 / TRPVチャネル / 癌 / Pharmacology / Pain / TRPV channel / 空間分解能 / 脳活動 / 筋活動 / 微小構造物 / ポジトロン放出断層法（PET） / 脳微細構造機能イメージング / フルオロデオキシグルコース（FDG） / ポジトロン放出断層法 Less

  • Research Projects

    (59 results)

  • Research Products

    (554 results)

  • Co-Researchers

    (137 People)

  •  ヒスタミン系薬理学研究に残された解決すべき重要な研究課題の解明Principal Investigator

    • Principal Investigator
      谷内 一彦
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 48030:Pharmacology-related
    • Research Institution
      Tohoku University

  •  Development of Fluorine-18 labeled protein PET molecular probes for the application to neurological diseasesPrincipal Investigator

    • Principal Investigator
      谷内 一彦
    • Project Period (FY)
      2020 – 2021
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 52:General internal medicine and related fields
    • Research Institution
      Tohoku University

  •  Development of protein-specific PET molecular imaging in neurodegenerative disordersPrincipal Investigator

    • Principal Investigator
      谷内 一彦
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
    • Review Section
      Medium-sized Section 52:General internal medicine and related fields
    • Research Institution
      Tohoku University

  •  Development of a novel labeling method for affibody by F-18 labeled amino acid and a cell-free protein synthesis systemPrincipal Investigator

    • Principal Investigator
      Yanai Kazuhiko
    • Project Period (FY)
      2016 – 2017
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Applied pharmacology
    • Research Institution
      Tohoku University

  •  Elucidation of neural network disruption mechanisms by protein specific PET imagingPrincipal Investigator

    • Principal Investigator
      Yanai Kazuhiko
    • Project Period (FY)
      2014 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Biological Sciences
    • Research Institution
      Tohoku University

  •  Analysis of histamine system through genetically modified micePrincipal Investigator

    • Principal Investigator
      Yanai Kazuhiko
    • Project Period (FY)
      2014 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      General pharmacology
    • Research Institution
      Tohoku University

  •  Molecular mechanism of brain histamine clearancePrincipal Investigator

    • Principal Investigator
      YANAI Kazuhiko
    • Project Period (FY)
      2014
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      General pharmacology
    • Research Institution
      Tohoku University

  •  Imaging glucose consumption in small structures in the human brain and cancer with a high resolution scanner

    • Principal Investigator
      TASHIRO Manabu
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Radiation science
    • Research Institution
      Tohoku University

  •  The Research Project on Regulation and Support Systems of Biomedical Research.

    • Principal Investigator
      Yonemura Shigeto
    • Project Period (FY)
      2012 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      New fields of law
    • Research Institution
      The University of Tokyo
      Tohoku University

  •  Generation of molecular imaging pharmacology using small primate mamosetsPrincipal Investigator

    • Principal Investigator
      YANAI KAZUHIKO
    • Project Period (FY)
      2012 – 2013
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Applied pharmacology
    • Research Institution
      Tohoku University

  •  Integrated research of histamine system from molecular to wholeanimals and humans using leading-edge technologiesPrincipal Investigator

    • Principal Investigator
      YANAI Kazuhiko
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Applied pharmacology
    • Research Institution
      Tohoku University

  •  Suppressive role of histamine in inflammation-associated tumorigenesis

    • Principal Investigator
      KURAMASU Atsuo
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General pharmacology
    • Research Institution
      Yamaguchi University

  •  Scientific evaluation of therapeutic effects and mechanism of alternative therapies using PET molecular imaging technique.

    • Principal Investigator
      TASHIRO Manabu
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General internal medicine (including Psychosomatic medicine)
    • Research Institution
      Tohoku University

  •  神経創薬に応用可能な神経イメージング基技術の萌芽的開発Principal Investigator

    • Principal Investigator
      谷内 一彦
    • Project Period (FY)
      2009 – 2010
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Neurochemistry/Neuropharmacology
    • Research Institution
      Tohoku University

  •  PETを用いた分子イメージングによる神経変性疾患の病態解明

    • Principal Investigator
      岡村 信行
    • Project Period (FY)
      2008 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Tohoku University

  •  Molecular Neuropharmacology on histamine system : From basic to clinical investigation on unsolved issuesPrincipal Investigator

    • Principal Investigator
      YANAI Kazuhiko
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      General pharmacology
    • Research Institution
      Tohoku University

  •  Development of a microreactor for radiosynthesis of ^<18>F-probes

    • Principal Investigator
      IWATA Ren
    • Project Period (FY)
      2007 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Radiation science
    • Research Institution
      Tohoku University

  •  分子イメージングおよび脳機能イメージングを用いた認知機能障害発現機構の解明

    • Principal Investigator
      岡村 信行
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Tohoku University

  •  多重ヒスタミン受容体関連遺伝子ノックアウトマウス開発による副作用発現予測研究Principal Investigator

    • Principal Investigator
      谷内 一彦
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Applied pharmacology
    • Research Institution
      Tohoku University

  •  The effects of stress exposure in weanling mice on cognitive function and neurogenesis: the role of histaminergic neuron systems

    • Principal Investigator
      SAKURAI Eiko
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurochemistry/Neuropharmacology
    • Research Institution
      Tohoku University

  •  Attempt of Cancer Pain Control with the aid of Anti-TRPV Channel Antibody

    • Principal Investigator
      YANAGISAWA Teruyuki
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pain science
    • Research Institution
      Tohoku University

  •  Development of Semiconductor PET Scanner with the Ultra High Resolutionof less than 1mm FWHM : Next Generation PET

    • Principal Investigator
      ISHII Keizo
    • Project Period (FY)
      2005 – 2009
    • Research Category
      Grant-in-Aid for Specially Promoted Research
    • Review Section
      Science and Engineering
      Engineering
    • Research Institution
      Tohoku University

  •  PETによる分子・機能イメージングを組み合わせたヒトの認知・注意・感情の機能研究

    • Principal Investigator
      岡村 信行
    • Project Period (FY)
      2005
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Tohoku University

  •  トランスレーショナルPET研究の有用性の確立と安全性基準Principal Investigator

    • Principal Investigator
      谷内 一彦
    • Project Period (FY)
      2005
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Radiation science
    • Research Institution
      Tohoku University

  •  A study of the histamine neuron system: Its correlation to newly-discovered hypothalamic peptides.Principal Investigator

    • Principal Investigator
      YANAI Kazuhiko
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Applied pharmacology
    • Research Institution
      Tohoku University

  •  Research for novel ^<18>F-labeled radiopharmaceuticals prepared by [^<18>F]fluoromethylation.

    • Principal Investigator
      IWATA Reni
    • Project Period (FY)
      2004 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Radiation science
    • Research Institution
      Tohoku University

  •  PETと遺伝子多型を組み合わせたヒト脳における薬物透過性と脳機能研究法の開発Principal Investigator

    • Principal Investigator
      谷内 一彦
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Applied pharmacology
    • Research Institution
      Tohoku University

  •  A study of the histamine neuron system : Its correlation to newly-discovered hypothalamic peptides.Principal Investigator

    • Principal Investigator
      YANAI Kazuhiko
    • Project Period (FY)
      2002 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      General pharmacology
    • Research Institution
      Tohoku University

  •  第8回Human Brain Mappingサテライト・シンポジウムの準備Principal Investigator

    • Principal Investigator
      谷内 一彦
    • Project Period (FY)
      2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      応用薬理学・医療系薬学
    • Research Institution
      Tohoku University

  •  Assessment of function of histamine using histidine decarboxylase gene-manupulated mice

    • Principal Investigator
      OHTSU Hiroshi, 渡邉 建彦
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      General pharmacology
    • Research Institution
      Tohoku University

  •  Development of miniaturized synthesis modules for preparation of PET radiopharmaceuticals

    • Principal Investigator
      IWATA Ren
    • Project Period (FY)
      2001 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Radiation science
    • Research Institution
      Tohoku University

  •  リガンド賦活法を用いたヒト脳における神経伝達物質遊離測定法の開発Principal Investigator

    • Principal Investigator
      谷内 一彦
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Neurochemistry/Neuropharmacology
    • Research Institution
      Tohoku University

  •  The new perspectives of knockout mice and positron emission temography in the development and evaluation of drugsPrincipal Investigator

    • Principal Investigator
      YANAI Kazuhiko
    • Project Period (FY)
      2000 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      General pharmacology
    • Research Institution
      Tohoku University

  •  Investigation of mechanism of stimulant-induced psychosis -Imaging study by PET -

    • Principal Investigator
      HISHINUMA Takanori, MIZUGAKI Michinao
    • Project Period (FY)
      2000 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      応用薬理学・医療系薬学
    • Research Institution
      TOHOKU UNIVERSITY

  •  3次元PETと脳賦活試験法を用いた高次脳機能の研究Principal Investigator

    • Principal Investigator
      谷内 一彦
    • Project Period (FY)
      1999
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      Tohoku University

  •  Role of brain histamine on refractory schizophrenia

    • Principal Investigator
      ITO Chihiro, 佐藤 光源
    • Project Period (FY)
      1999 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Psychiatric science
    • Research Institution
      Tohoku University

  •  The development of an efficient, rapid method for [^<18>F] fluorobenzyl iodide as a versatile labeling precursor.

    • Principal Investigator
      IWATA Ren
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Radiation science
    • Research Institution
      Tohoku University

  •  Basic Research for the role and mechanism of histamine in visual procession

    • Principal Investigator
      NAKAGAWA Yoichi
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Ophthalmology
    • Research Institution
      Tohoku University

  •  The development for novel positron-labeled radiopharmaceuticals and their application to measurement of the cerebral functionsPrincipal Investigator

    • Principal Investigator
      YANAI Kazuhiko
    • Project Period (FY)
      1999 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      応用薬理学・医療系薬学
    • Research Institution
      Tohoku University

  •  ヒスチジン脱炭酸酵素遺伝子ノックアウトマウスを用いたヒスタミンと神経可塑性の研究

    • Principal Investigator
      渡邊 建彦
    • Project Period (FY)
      1998
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      Tohoku University

  •  3次元PETと脳賦活試験法を用いた高次脳機能の研究Principal Investigator

    • Principal Investigator
      谷内 一彦
    • Project Period (FY)
      1998
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      Tohoku University

  •  Studies on Brain Histamine Neurons Using Gene-Targetted Mice

    • Principal Investigator
      WATANABE Takehiko
    • Project Period (FY)
      1998 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (A).
    • Research Field
      Neurochemistry/Neuropharmacology
    • Research Institution
      Tohoku University

  •  ヒスタミン受容体および合成酵素のイックアウトマウスを用いた神経可塑性の研究

    • Principal Investigator
      渡邊 建彦
    • Project Period (FY)
      1997
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tohoku University

  •  3次元PETと脳賦活試験法を用いた高次脳機能の研究Principal Investigator

    • Principal Investigator
      谷内 一彦
    • Project Period (FY)
      1997
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tohoku University

  •  ヒスタミン・トランスポーターの阻害剤の開発

    • Principal Investigator
      渡邉 建彦
    • Project Period (FY)
      1997
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      General pharmacology
    • Research Institution
      Tohoku University

  •  ヒスタミンの脳機能における役割の解明--国際学術共同研究をめざして

    • Principal Investigator
      渡邉 建彦
    • Project Period (FY)
      1997
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurochemistry/Neuropharmacology
    • Research Institution
      Tohoku University

  •  Pharmacological PET receptor imaging and its application to drug development

    • Principal Investigator
      WATANABA Takehiko
    • Project Period (FY)
      1997 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (A).
    • Research Field
      General pharmacology
    • Research Institution
      Tohoku University

  •  The development of a new radioligand having a [^<18>F] fluorobenzyl group for functional imaging of neurotransmitters by PET.

    • Principal Investigator
      IWATA Ren
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Radiation science
    • Research Institution
      Tohoku University

  •  ヒスタミン受容体と神経可塑性:ヒスタミン受容体ノックアウトマウスを用いた研究

    • Principal Investigator
      渡邉 建彦
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tohoku University

  •  ヒスタミンH_3受容体とヒスタミン・トランスポーターの薬理学的研究Principal Investigator

    • Principal Investigator
      谷内 一彦
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General pharmacology
    • Research Institution
      Tohoku University

  •  Neurotransmission in human brains measured by 3D-PETPrincipal Investigator

    • Principal Investigator
      YANAI Kazuhiko
    • Project Period (FY)
      1996 – 1998
    • Research Category
      Grant-in-Aid for international Scientific Research
    • Research Field
      Neurochemistry/Neuropharmacology
    • Research Institution
      Tohoku University

  •  Molecular pharmacology of histamine system

    • Principal Investigator
      WATANABE Takehiko
    • Project Period (FY)
      1996 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      General pharmacology
    • Research Institution
      TOHOKU UNIVERSITY

  •  神経可塑性におけるヒスタミンH3受容体

    • Principal Investigator
      WATANABE Takehiko
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tohoku University

  •  Application of positron-labeled radiopharmaceuticals and 3-D PET to NeurosciencePrincipal Investigator

    • Principal Investigator
      YANAI Kazuhiko
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Neuroscience in general
    • Research Institution
      Tohoku University

  •  Imaging of neurotransmission in humnan brains : Normal and abnormal aging.Principal Investigator

    • Principal Investigator
      YANAI Kazuhiko
    • Project Period (FY)
      1994 – 1995
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      老化(加齢)
    • Research Institution
      Tohoku University of Medicine

  •  新しい技術によるヒスタミンH-3受容体の構造と機能の解明Principal Investigator

    • Principal Investigator
      谷内 一彦
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      General pharmacology
    • Research Institution
      Tohoku University

  •  New perspectives in research for histaminergic functions in CNS

    • Principal Investigator
      WATANABE Takehiko
    • Project Period (FY)
      1993 – 1994
    • Research Category
      Grant-in-Aid for international Scientific Research
    • Research Institution
      Tohoku University

  •  Histamine and learning-memory and convulsion

    • Principal Investigator
      WATANABE Takehiko
    • Project Period (FY)
      1993 – 1994
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Neurochemistry/Neuropharmacology
    • Research Institution
      Tohoku University Medical School

  •  Drug development with histamine H3 receptor as a target

    • Principal Investigator
      WATANABE Takehiko
    • Project Period (FY)
      1993 – 1995
    • Research Category
      Grant-in-Aid for Developmental Scientific Research (B)
    • Research Field
      General pharmacology
    • Research Institution
      Tohoku University

All 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 Other

All Journal Article Presentation Book Patent

  • [Book] ヒスタミンの作用、選択的H1受容体拮抗作用宮地良樹、ファーマーナビゲーター2012
    • Author(s)
      谷内一彦
    • Publisher
      メディカルレビュー社
    • Data Source
      KAKENHI-PROJECT-21390171

  • [Book] PET Studies of Brain Metabolism in Exercise Research. IN : Functional Neuroimaging in Exercise and Sport Sciences2012
    • Author(s)
      Tashiro M, Fujimoto T, Masud MM, Khondkar S, Watanuki S, Yanai K, Itoh M, Ishii K
    • Publisher
      Springer. New York, USA(印刷中)
    • Data Source
      KAKENHI-PROJECT-21590754

  • [Book] ファーマーナビゲーター:抗ヒスタミン薬編2012
    • Author(s)
      宮地良樹、岡本美孝、谷内一彦(編・著)
    • Total Pages
      300
    • Publisher
      メディカルレビュー社
    • Data Source
      KAKENHI-PROJECT-24659255

  • [Book] 抗ヒスタミン薬編2012
    • Author(s)
      宮地良樹、岡本美孝、谷内一彦
    • Publisher
      メディカルレビュー社
    • Data Source
      KAKENHI-PROJECT-21390171

  • [Book] PET Studies of Brain Metabolism in Exercise Research. IN : Functional Neuroimaging in Exercise and Sport Sciences2011
    • Author(s)
      Tashiro M, Fujimoto T, Masud MM, Khondkar S, Watanuki S, Yanai K, Itoh M, Ishii K
    • Publisher
      Springer. New York, USA(印刷中)
    • Data Source
      KAKENHI-PROJECT-21590754

  • [Book] 頸部痛患者におけるカイロプラクティック施術後の局所脳代謝変化2011
    • Author(s)
      小倉毅、田代学、メヘディ・マスード、四月朔日聖一、渋谷勝彦、谷内一彦、山口慶一郎、伊藤正敏
    • Publisher
      日本カイロプラクティック徒手医学会
    • Data Source
      KAKENHI-PROJECT-21590754

  • [Book] Quantitative Analysis of Amyloid β Deposition in Patients with Alzheimer's Disease Using Positr on Emission Tomography. IN : Early Detection and Rehabilitation Technologies for Dementia : Neuroscience and Biomedical Applications2011
    • Author(s)
      Tashiro M, Okamura N, Watanuki S, Furumoto S, Furukawa K, Funaki Y, Iwata R, Kudo Y, Arai H, Watabe H, Yanai K
    • Publisher
      IGI Global. Philadelphia, USA
    • Data Source
      KAKENHI-PROJECT-21590754

  • [Book] Nano-bio-imaging with radiopharmaceuticals and its application to health sciences2011
    • Author(s)
      Tashiro M, Hiraoka K, Watanuki S, Masud MM, Miyake M, Kumagai K, Ogura T, Yanai K
    • Publisher
      Research Publishing Services
    • Data Source
      KAKENHI-PROJECT-21590754

  • [Book] Molecular and functional imaging for drug development and elucidation of disease mechanisms using positron emission tomography (PET)2010
    • Author(s)
      Tashiro M, Fujimoto T, Okamura N, Iwata R, Yanai K
    • Publisher
      Springer Japan
    • Data Source
      KAKENHI-PROJECT-21590754

  • [Book] 特集「ヒスタミンH1受容体拮抗薬の臨床」アレルギーの臨床2010
    • Author(s)
      谷内一彦
    • Total Pages
      1236
    • Publisher
      北隆館
    • Data Source
      KAKENHI-PROJECT-21390171

  • [Book] Molecular and functional imaging for drug development and elucidation of disease mechanisms. Molecular Imaging for Integrated Medical Therapy2010
    • Author(s)
      Tashiro M, Fujitmoto T, Okamura N, Iwata R, Yanai K
    • Publisher
      Springer. New York, USA
    • Data Source
      KAKENHI-PROJECT-21590754

  • [Book] ヒスタミンH1受容体占拠率による脳内移行性評価.In:創薬技術の革新マイクロドーズからPET分子イメージングへの新展開2010
    • Author(s)
      谷内一彦、田代学、古本祥三、吉川雄朗、岡村信行
    • Publisher
      メディカルドゥ社
    • Data Source
      KAKENHI-PROJECT-21590754

  • [Book] Quantitative Analysis of Amyloid β Deposition in Alzheimer's Disease Patients and Healthy Volunteers Using Positron Emission Tomography. In : Early Detection and Rehabilitation Technologies for Dementia : Neuroscience and Biomedical Applications2010
    • Author(s)
      Tashiro M, Okamura N, Watanuki S, Furumoto S, Furukawa K, Funaki Y, Iwata R, Kudo Y, Arai H, Watabe H, Yanai K.
    • Publisher
      (株)複合医工学研究所(印刷中)
    • Data Source
      KAKENHI-PROJECT-21590754

  • [Book] [^<11>C]BF-227 study of patients with protein misfolding diseases. In : Early Detection and Rehabilitation Technologies for Dementia : Neuroscience and Biomedical Applications2010
    • Author(s)
      Okamura N, Furumoto S, Tashiro M, Furukawa K, Arai H, Doh-ura K, Kudo Y, Yanai K.
    • Publisher
      (株)複合医工学研究所(印刷中)
    • Data Source
      KAKENHI-PROJECT-21590754

  • [Book] Inflamm Res2009
    • Author(s)
      Sakurai E, Sakurai E, Watanabe T, Yanai K
    • Publisher
      Uptake of L-histidine and histamine biosynthesis at the blood-brain barrier
    • Data Source
      KAKENHI-PROJECT-19390061

  • [Book] "Nano-Biomedical Engineering 2009 : Proceedings of the Tohoku University Global Centre of Excellence Programme" (Editor : Takami Yamaguchi)2009
    • Author(s)
      Yanai K, Okamura N, Iwata R, Tashiro M.
    • Total Pages
      469
    • Publisher
      Molecular imaging and its application to drug development at Tohoku University.
    • Data Source
      KAKENHI-PROJECT-19390061

  • [Book] Inflamm Res2009
    • Author(s)
      Sakurai E, Kuramasu A, Watanabe T, Yanai K
    • Publisher
      Multiple histamine receptor gene knockout mice and their phenotypes
    • Data Source
      KAKENHI-PROJECT-19390061

  • [Book] Inflamm Res2008
    • Author(s)
      Yanai K, Dai H, Sakurai E, Watanabe T
    • Publisher
      The roles of histamine H1 receptors on cognition
    • Data Source
      KAKENHI-PROJECT-19390061

  • [Book] Future Medical Engineering Based on Bionanotechnology Proceedings of the final symposium of the Tohoku University 21st Century Center of Excellence Program (Ed. M Esashi, K Ishii, N Ohuchi, N Osumi, T Yamaguchi),2006
    • Author(s)
      Hongmei Dai, Eiko Sakurai, Keizo Ishii, Kazuhiko Yanai.
    • Publisher
      Imperial College Press
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18500286

  • [Book] PET Studies of Brain Metabolism in Exercise Research
    • Author(s)
      Tashiro M, Fujimoto T, Masud MM, Khondkar S, Watanuki S, Yanai K, Itoh M, Ishii K
    • Publisher
      Springer
    • Data Source
      KAKENHI-PROJECT-21590754

  • [Journal Article] Synthesis and pharmacokinetic characterisation of a fluorine-18 labelled brain shuttle peptide fusion dimeric affibody2021
    • Author(s)
      Morito Takahiro、Harada Ryuichi、Iwata Ren、Du Yiqing、Okamura Nobuyuki、Kudo Yukitsuka、Yanai Kazuhiko
    • Journal Title

      Scientific Reports

      Volume: 11 Pages: 2588-2588

    • DOI

      10.1038/s41598-021-82037-2

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K21564, KAKENHI-PROJECT-19KK0212, KAKENHI-PROJECT-20H03614

  • [Journal Article] 18F-SMBT-1: A Selective and Reversible PET Tracer for Monoamine Oxidase-B Imaging2021
    • Author(s)
      Harada R, Hayakawa Y, Ezura M, Lerdsirisuk P, Du Y, Ishikawa Y, Iwata R, Shidahara M, Ishiki A, Kikuchi A, Arai H, Kudo Y, Yanai K, Furumoto S, Okamura N
    • Journal Title

      Journal of Nuclear Medicine

      Volume: 62 Pages: 253-258

    • DOI

      10.2967/jnumed.120.244400

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K09789, KAKENHI-PROJECT-20K07879, KAKENHI-PROJECT-20K08043, KAKENHI-PROJECT-18K15357, KAKENHI-PROJECT-19KK0212, KAKENHI-PROJECT-20H03614

  • [Journal Article] タンパク質医薬品開発のためのポジトロン放出核種標識タンパク質2020
    • Author(s)
      原田龍一、盛戸貴裕、谷内一彦
    • Journal Title

      日本薬理学会雑誌

      Volume: 155 Pages: 159-163

    • NAID

      130007839036

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19KK0212

  • [Journal Article] Histamine N-Methyltransferase in the Brain.2019
    • Author(s)
      Yoshikawa Takeo、Nakamura Tadaho、Yanai Kazuhiko
    • Journal Title

      Int J Mol Sci.

      Volume: 20 Pages: 737-737

    • DOI

      10.3390/ijms20030737

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K06886, KAKENHI-PLANNED-26117003

  • [Journal Article] Imaging protein misfolding in the brain using β-Sheet ligands.2019
    • Author(s)
      Harada Ryuichi、Okamura Nobuyuki、Furumoto Shozo、Yanai Kazuhiko
    • Journal Title

      Front Neurosci.

      Volume: 12 Pages: 585-585

    • DOI

      10.3389/fnins.2018.00585

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18H02771, KAKENHI-PROJECT-16K15570, KAKENHI-PROJECT-18K15538, KAKENHI-PLANNED-26117003

  • [Journal Article] ポジトロン放出核種標識タンパク質の新規合成方法の開発2019
    • Author(s)
      原田龍一、盛戸貴裕、谷内一彦
    • Journal Title

      バイオインダストリー

      Volume: 36 Pages: 46-54

    • Data Source
      KAKENHI-PROJECT-19KK0212

  • [Journal Article] Site-Specific Labeling of F-18 Proteins Using a Supplemented Cell-Free Protein Synthesis System and O-2-[18F]Fluoroethyl-L-Tyrosine: [18F]FET-HER2 Affibody Molecule.2019
    • Author(s)
      Yanai Ai、Harada Ryuichi、Iwata Ren、Yoshikawa Takeo、Ishikawa Yoichi、Furumoto Shozo、Ishida Takanori、Yanai Kazuhiko
    • Journal Title

      Mol Imaging Biol.

      Volume: -

    • DOI

      10.1007/s11307-018-1266-z

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16H05383, KAKENHI-PROJECT-18K15538, KAKENHI-PLANNED-26117003

  • [Journal Article] Longitudinal changes in 18F-THK5351 positron emission tomography in corticobasal syndrome.2019
    • Author(s)
      Ezura M, Kikuchi A, Ishiki A, Okamura N, Hasegawa T, Harada R, Watanuki S, Funaki Y, Hiraoka K, Baba T, Sugeno N, Oshima R, Yoshida S, Kobayashi J, Kobayashi M, Tano O, Nakashima I, Mugikura S, Iwata R, Taki Y, Furukawa K, Arai H, Furumoto S, Tashiro M, Yanai K, Kudo Y, Takeda A, Aoki M
    • Journal Title

      European Journal of Neurology

      Volume: 26 Pages: 1205-1211

    • DOI

      10.1111/ene.13966

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K09789, KAKENHI-PROJECT-17K20083, KAKENHI-PROJECT-19KK0212, KAKENHI-PROJECT-16H05385, KAKENHI-PROJECT-17K09318, KAKENHI-PROJECT-17K09744, KAKENHI-PROJECT-17K09745, KAKENHI-PROJECT-18K15538, KAKENHI-PROJECT-18H02771

  • [Journal Article] Targeting metals rescues the phenotyope in an animal model of tauopathy.2018
    • Author(s)
      Sedjahtera Amelia、Gunawan Lydia、Bray Lisa、Hung Lin Wai、Parsons Jack、Okamura Nobuyuki、Villemagne Victor L.、Yanai Kazuhiko、Liu Xiang M.、Chan Jacky、Bush Ashley I.、Finkelstein David I.、Barnham Kevin J.、Cherny Robert A.、Adlard Paul A.
    • Journal Title

      Metallomics.

      Volume: 10 Pages: 1339-1347

    • DOI

      10.1039/c8mt00153g

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18H02771, KAKENHI-PLANNED-26117003

  • [Journal Article] Newly-Developed Positron Emission Mammography (PEM) Device for the Detection of Small Breast Cancer2018
    • Author(s)
      Yanai A, Itoh M, Hirakawa H, Yanai K, Tashiro M, Harada R, Yoshikawa A, Yamamoto S, Ohuchi N, Ishida T.
    • Journal Title

      Tohoku J. Exp. Med.

      Volume: 245 Issue: 1 Pages: 13-19

    • DOI

      10.1620/tjem.245.13

    • NAID

      130006731329

    • ISSN
      0040-8727, 1349-3329
    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K20083, KAKENHI-PROJECT-16H05385, KAKENHI-PROJECT-18K15538, KAKENHI-PLANNED-26117003

  • [Journal Article] Neuroimaging-pathological correlations of [18F]THK5351 PET in progressive supranuclear palsy.2018
    • Author(s)
      Ishiki A, Harada R, Kai H, Sato N, Totsune T, Tomita N, Watanuki S, Hiraoka K, Ishikawa Y, Funaki Y, Iwata R, Furumoto S, Tashiro M, Sasano H, Kitamoto T, Kudo Y, Yanai K, Furukawa K, Okamura N, Arai H.
    • Journal Title

      Acta Neuropathol Commun.

      Volume: 6 Pages: 53-53

    • DOI

      10.1186/s40478-018-0556-7

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K09318, KAKENHI-PROJECT-17K20083, KAKENHI-PROJECT-16H05383, KAKENHI-PROJECT-16H05385, KAKENHI-PROJECT-18H02738, KAKENHI-PROJECT-18H02771, KAKENHI-PROJECT-16K15570, KAKENHI-PROJECT-16H06277, KAKENHI-PROJECT-18K15538, KAKENHI-PLANNED-26117003

  • [Journal Article] Practical microscale one-pot radiosynthesis of 18F-labeled probes2018
    • Author(s)
      Iwata R, Pascali C, Terasaki K, Ishikawa Y, Furumoto S, Yanai K.
    • Journal Title

      Journal of Labelled Compounds and Radiopharmaceuticals

      Volume: 17 Pages: 1-10

    • DOI

      10.1002/jlcr.3618

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K10370, KAKENHI-PROJECT-16H05383, KAKENHI-PLANNED-26117003

  • [Journal Article] Correlations of 18F-THK5351 PET with post-mortem burden of tau and astrogliosis in Alzheimer's disease.2018
    • Author(s)
      Brendel M, Furukawa K, et al.
    • Journal Title

      J. Nucl. Med.

      Volume: 24 Pages: 130-136

    • DOI

      10.2967/jnumed.117.197426

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K09318, KAKENHI-PROJECT-16K15570, KAKENHI-PROJECT-17K20083, KAKENHI-PLANNED-26117003, KAKENHI-PROJECT-26253016, KAKENHI-PROJECT-15H04900, KAKENHI-PROJECT-16H05383, KAKENHI-PROJECT-16H05385, KAKENHI-PROJECT-16H06621, KAKENHI-PROJECT-16H07486, KAKENHI-PROJECT-15K08127

  • [Journal Article] [18F]-THK5351 PET Imaging in Patients With Semantic Variant Primary Progressive Aphasia.2018
    • Author(s)
      Kang JM, Lee SY, Seo S, Jeong HJ, Woo SH, Lee H, Lee YB, Yeon BK, Shin DH, Park KH, Kang H, Okamura N, Furumoto S, Yanai K, Villemagne VL, Seong JK, Na DL, Ido T, Cho J, Lee KM, Noh Y
    • Journal Title

      Alzheimer Dis Assoc Disord.

      Volume: 59 Pages: 210-219

    • DOI

      10.1097/wad.0000000000000216

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-26117003, KAKENHI-PROJECT-15H04900

  • [Journal Article] Histamine elicits glutamate release from cultured astrocytes.2018
    • Author(s)
      Karpati Aniko、Yoshikawa Takeo、Nakamura Tadaho、Iida Tomomitsu、Matsuzawa Takuro、Kitano Haruna、Harada Ryuichi、Yanai Kazuhiko
    • Journal Title

      J Pharmacol Sci.

      Volume: 137 Pages: 122-128

    • DOI

      10.1016/j.jphs.2018.05.002

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K06886, KAKENHI-PROJECT-18J11446, KAKENHI-PROJECT-18K15538, KAKENHI-PLANNED-26117003

  • [Journal Article] Involvement of the Precuneus/Posterior Cingulate Cortex Is Significant for the Development of Alzheimer's Disease: A PET (THK5351, PiB) and Resting fMRI Study.2018
    • Author(s)
      Yokoi Takamasa、Watanabe Hirohisa、Ishigaki Shinsuke、Katsuno Masahisa、Miyao Shinichi、Kato Katsuhiko、Naganawa Shinji、Harada Ryuichi、Okamura Nobuyuki、Yanai Kazuhiko、Yoshida Mari、Sobue Gen （ほか9名）
    • Journal Title

      Front Aging Neurosci

      Volume: 10 Pages: 304-304

    • DOI

      10.3389/fnagi.2018.00304

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K07367, KAKENHI-PROJECT-18K19510, KAKENHI-ORGANIZER-26117001, KAKENHI-PLANNED-26117002, KAKENHI-PLANNED-26117004, KAKENHI-PROJECT-17H04259, KAKENHI-PROJECT-18H02771, KAKENHI-PROJECT-17K16117, KAKENHI-PROJECT-18K15538, KAKENHI-PLANNED-26117003

  • [Journal Article] Distinct roles of small GTPases Rac1 and Rac2 in Histamine H4 receptor-mediated chemotaxis of mast cells2018
    • Author(s)
      Kuramasu Atsuo、Wakabayashi Mie、Inui Makoto、Yanai Kazuhiko
    • Journal Title

      J Pharmacol Exp Ther.

      Volume: 367 Pages: 9-19

    • DOI

      10.1124/jpet.118.249706

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17H04033, KAKENHI-PROJECT-16K15203, KAKENHI-PLANNED-26117003

  • [Journal Article] Heparan sulfate in pancreatic β-cells contributes to normal glucose homeostasis by regulating insulin secretion2018
    • Author(s)
      Matsuzawa T, Yoshikawa T, Iida T, Karpati A, Kitano H, Harada R, Nakamura T, Sugawara A, Yamaguchi Y, Yanai K.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: - Pages: 688-605

    • DOI

      10.1016/j.bbrc.2018.03.213

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26253016, KAKENHI-PROJECT-16K18389, KAKENHI-PROJECT-18K06886, KAKENHI-PROJECT-16H03252, KAKENHI-PROJECT-18J11446, KAKENHI-PROJECT-18K15538, KAKENHI-PLANNED-26117003

  • [Journal Article] Tau imaging with [18 F]THK-5351 in progressive supranuclear palsy.2017
    • Author(s)
      Ishiki A, Harada R, Okamura N, Tomita N, Rowe CC, Villemagne VL, Yanai K, Kudo Y, Arai H, Furumoto S, Tashiro M, Furukawa K.
    • Journal Title

      Eur J Neurol

      Volume: 24 Pages: 130-136

    • DOI

      10.1111/ene.13164

    • Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-26117003, KAKENHI-PROJECT-15H04900, KAKENHI-PROJECT-15K15268, KAKENHI-PROJECT-15K19767, KAKENHI-PROJECT-17K09318, KAKENHI-PROJECT-16H06621

  • [Journal Article] Activated Braf induces esophageal dilation and gastric epithelial hyperplasia in mice2017
    • Author(s)
      Inoue Shin-Ichi、Takahara Shingo、Yoshikawa Takeo、Niihori Tetsuya、Yanai Kazuhiko、Matsubara Yoichi、Aoki Yoko
    • Journal Title

      Human Molecular Genetics

      Volume: 26 Pages: 4715-4727

    • DOI

      10.1093/hmg/ddx354

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K10045, KAKENHI-PROJECT-26253016, KAKENHI-PROJECT-16K18389, KAKENHI-PROJECT-17H04223, KAKENHI-PROJECT-15K19598

  • [Journal Article] The clinical pharmacology of non-sedating antihistamines2017
    • Author(s)
      Yanai K, Yoshikawa T, Yanai A, Nakamura T, Iida T, Leurs R, Tashiro M.
    • Journal Title

      Pharmacol Ther

      Volume: 178 Pages: 148-156

    • DOI

      10.1016/j.pharmthera.2017.04.004

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K20083, KAKENHI-PROJECT-26253016, KAKENHI-PROJECT-16H05385, KAKENHI-PROJECT-16K18389

  • [Journal Article] Applications of tau PET imaging2017
    • Author(s)
      Okamura N, Yanai K.
    • Journal Title

      Nature Reviews Neurology

      Volume: 13 Pages: 197-198

    • DOI

      10.1038/nrneurol.2017.38

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PLANNED-26117003, KAKENHI-PROJECT-15H04900

  • [Journal Article] Histamine Clearance Through Polyspecific Transporters in the Brain.2017
    • Author(s)
      Yoshikawa T and Yanaik
    • Journal Title

      Handb Exp Pharmacol.

      Volume: 印刷中

    • DOI

      10.1007/164_2016_13

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26253016, KAKENHI-PROJECT-16K18389

  • [Journal Article] Prediction of the clinical standardized uptake value ratio in amyloid PET imaging using a biomathematical modeling approach towards the efficient development of a radioligand2017
    • Author(s)
      Arakawa Y, Nai Y, Shidahara M, Furumoto S, Seki C, Okamura N, Tashiro M, Kudo Y, Yanai K, Gonda K, Watabe H.
    • Journal Title

      Journal of Nuclear Medicine

      Volume: - Pages: 1285-1292

    • DOI

      10.2967/jnumed.116.183566

    • Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-26117003, KAKENHI-PROJECT-26293133, KAKENHI-PROJECT-15K08687, KAKENHI-PROJECT-15H04900

  • [Journal Article] Histamine N-methyltransferase regulates aggression and the sleep-wake cycle.2017
    • Author(s)
      Naganuma Fumito、Nakamura Tadaho、Yoshikawa Takeo、Iida Tomomitsu、Miura Yamato、Karpati Aniko、Matsuzawa Takuro、Yanai Atushi、Mogi Asuka、Mochizuki Takatoshi、Okamura Nobuyuki、Yanai Kazuhiko
    • Journal Title

      Sci Rep.

      Volume: 7 Pages: 15899-15899

    • DOI

      10.1038/s41598-017-16019-8

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K16753, KAKENHI-PROJECT-26253016, KAKENHI-PROJECT-15H04900, KAKENHI-PROJECT-16K18389

  • [Journal Article] Induced histamine regulates Ni elution from an implanted Ni wire in mice by downregulating neutrophil migration2017
    • Author(s)
      Kishimoto Y, Asakawa S, Sato T, Takano T, Nakajyo T, Mizuno N, Segawa R, Yoshikawa T, Hiratsuka M, Yanai K, Ohtsu H, Hirasawa N.
    • Journal Title

      Exp Dermatol

      Volume: 印刷中 Pages: 868-874

    • DOI

      10.1111/exd.13315

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26253016, KAKENHI-PROJECT-16K18389

  • [Journal Article] JNJ10181457, a histamine H3 receptor inverse agonist, regulates in vivo microglial functions and improves depression-like behaviours in mice2017
    • Author(s)
      Iida Tomomitsu、Yoshikawa Takeo、Karpati Aniko、Matsuzawa Takuro、Kitano Haruna、Mogi Asuka、Harada Ryuichi、Naganuma Fumito、Nakamura Tadaho、Yanai Kazuhiko
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 488 Pages: 534-540

    • DOI

      10.1016/j.bbrc.2017.05.081

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26253016, KAKENHI-PROJECT-16J05282, KAKENHI-PROJECT-16K18389

  • [Journal Article] Characterization of murine polyspecific monoamine transporters.2017
    • Author(s)
      Miura Y, Yoshikawa T, Naganuma F, Nakamura T, Iida T, Karpati A, Matsuzawa T, Mogi A, Harada R, Yanai K.
    • Journal Title

      FEBS Open Bio

      Volume: 9 Pages: 237-248

    • DOI

      10.1002/2211-5463.12183

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26253016, KAKENHI-PROJECT-16J05282

  • [Journal Article] Preclinical Evaluation of [18F]THK-5105 Enantiomers: Effects of Chirality on its Effectiveness as a Tau Imaging Radiotracers2016
    • Author(s)
      Tago T., Furumoto S., Okamura N., Harada R., Adachi H., Ishikawa Y., Yanai K., Iwata R., Kudo Y.
    • Journal Title

      Mol Imaging Biol.

      Volume: 未定 Pages: 258-166

    • DOI

      10.1007/s11307-015-0879-8

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15K15444, KAKENHI-PROJECT-15K19767, KAKENHI-PLANNED-26117003, KAKENHI-PROJECT-14J06908, KAKENHI-PROJECT-25293257, KAKENHI-PROJECT-25293259, KAKENHI-PROJECT-15H04900

  • [Journal Article] A simulated car-driving study on the effects of acute administration of levocetirizine, fexofenadine, and diphenhydramine in healthy Japanese volunteers2016
    • Author(s)
      Inami A, Matsuda R, Grobosch T, Komamura H, Takeda K, Yamada Y, Miyake M, Hiraoka K, Maurer M, Yanai K, Tashiro M.
    • Journal Title

      Hum Psychopharmacol

      Volume: Epub ahead of print Pages: 167-77

    • DOI

      10.1002/hup.2524

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25670525, KAKENHI-PROJECT-15K08127

  • [Journal Article] Synthesis and characterization of 18F-interleukin-8 using a cell-free translation system and 18F-fluoro-L-proline2016
    • Author(s)
      Ryuichi Harada, Shozo Furumoto, Takeo Yoshikawa, Yoichi Ishikawa, Katsutoshi Shibuya, Nobuyuki Okamura, Kiichi Ishiwata, Ren Iwata, Kazuhiko Yanai
    • Journal Title

      J. Nucl. Med. Mol. Imag.

      Volume: 57(4) Pages: 634-639

    • DOI

      10.2967/jnumed.115.162602

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K19767, KAKENHI-PLANNED-26117003, KAKENHI-PROJECT-14J06908, KAKENHI-PROJECT-26253016, KAKENHI-PROJECT-15K15444, KAKENHI-PROJECT-16K18389

  • [Journal Article] Characteristics of Tau and Its Ligands in PET Imaging.2016
    • Author(s)
      Ryuichi Harada, Nobuyuki Okamura, Shozo Furumoto, Tetsuro Tago, Kazuhiko Yanai, Hiroyuki Arai, Yukitsuka Kudo
    • Journal Title

      Biomolecules.

      Volume: 6 Pages: 1-15

    • DOI

      10.3390/biom6010007

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15K19767, KAKENHI-PLANNED-26117003, KAKENHI-PROJECT-15H04900, KAKENHI-PROJECT-14J06908

  • [Journal Article] In vivo visualization of tau deposits in corticobasal syndrome by 18F-THK5351 PET.2016
    • Author(s)
      Kikuchi A, Okamura N, Hasegawa T, Harada R, Watanuki S, Funaki Y, Kobayashi M, Tano O, Baba T, Sugeno N, Oshima R, Yoshida S, Kobayashi J, Ezura M, Hiraoka K, Mugikura S, Takase K, Iwata R, Taki Y, Furukawa K, HArai H, Furumoto S, Tashiro M, Yanai K, Kudo Y, Takeda A，Aoki M.
    • Journal Title

      Neurology.

      Volume: 87 Pages: 2309-2316

    • DOI

      10.1212/wnl.0000000000003375

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PUBLICLY-15H01550, KAKENHI-PLANNED-26117003, KAKENHI-PROJECT-15H04900, KAKENHI-PROJECT-26461263, KAKENHI-PROJECT-15K19767, KAKENHI-PROJECT-26461303, KAKENHI-PROJECT-16K15570

  • [Journal Article] Advances in the development of tau PET radiotracers and their clinical applications2016
    • Author(s)
      Okamura N, Harada R, Furukawa K, Furumoto S, Tago T, Yanai K, Arai H, Kudo Y.
    • Journal Title

      Ageing Research Reviews

      Volume: - Pages: 107-113

    • DOI

      10.1016/j.arr.2015.12.010

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15K15268, KAKENHI-PROJECT-15K19767, KAKENHI-PLANNED-26117003, KAKENHI-PROJECT-14J06908, KAKENHI-PROJECT-15H04900, KAKENHI-PROJECT-16K15570

  • [Journal Article] Structure-Activity Relationship of 2-Arylquinolines as PET Imaging Tracers for Tau Pathology in Alzheimer's Disease.2016
    • Author(s)
      Tetsuro Tago, Shozo Furumoto, Nobuyuki Okamura, Ryuichi Harada, Hajime Adachi, Yoichi Ishikawa, Kazuhiko Yanai, Ren Iwata, and Yukitsuka Kudo
    • Journal Title

      J. Nucl. Med. Mol. Imag.

      Volume: 57(4) Pages: 608-614

    • DOI

      10.2967/jnumed.115.166652

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15K19767, KAKENHI-PLANNED-26117003, KAKENHI-PROJECT-14J06908, KAKENHI-PROJECT-25293259, KAKENHI-PROJECT-15H04900, KAKENHI-PROJECT-16H05383, KAKENHI-PROJECT-16K15570

  • [Journal Article] Dynamic PET Measures of Tau Accumulation in Cognitively Normal Older Adults and Alzheimer's Disease Patients Measured Using [18F] THK-5351.2016
    • Author(s)
      Lockhart SN, Baker SL, Okamura N, Furukawa K, Ishiki A, Furumoto S, Tashiro M, Yanai K, Arai H, Kudo Y, Harada R, Tomita N, Hiraoka K, Watanuki S, Jagust WJ.
    • Journal Title

      PLoS One

      Volume: 11

    • DOI

      10.1371/journal.pone.0158460

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-26117003, KAKENHI-PROJECT-15H04900, KAKENHI-PROJECT-15K08127, KAKENHI-PROJECT-16K15570

  • [Journal Article] Performance evaluation of the small-animal PET scanner ClairvivoPET using NEMA NU 4-2008 Standards.2016
    • Author(s)
      Sato K, Shidahara M, Watabe H, Watanuki S, Ishikawa Y, Arakawa Y, Nai YH, Furumoto S, Tashiro M, Shoji T, Yanai K, Gonda K.
    • Journal Title

      Phys Med Biol.

      Volume: 61 Pages: 696-711

    • DOI

      10.1088/0031-9155/61/2/696

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26253016, KAKENHI-PROJECT-25670525

  • [Journal Article] 18F-THK5351: A Novel PET Radiotracer for Imaging Neurofibrillary Pathology in Alzheimer Disease.2016
    • Author(s)
      Harada R, Okamura N, Furumoto S, Furukawa K, Ishiki A, Tomita N, Tago T, Hiraoka K, Watanuki S, Shidahara M, Miyake M, Ishikawa Y, Matsuda R, Inami A, Yoshikawa T, Funaki Y, Iwata R, Tashiro M, Yanai K, Arai H, Kudo Y
    • Journal Title

      Eur. J. Nucl. Med. Mol. Imag.

      Volume: 57 Pages: 208-214

    • DOI

      10.2967/jnumed.115.164848

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15K08127, KAKENHI-PROJECT-15K15268, KAKENHI-PROJECT-15K19767, KAKENHI-PLANNED-26117003, KAKENHI-PROJECT-26253016, KAKENHI-PROJECT-15H04900, KAKENHI-PROJECT-14J06908, KAKENHI-PROJECT-25670525, KAKENHI-PROJECT-26830041, KAKENHI-PROJECT-25293259, KAKENHI-PROJECT-16H05383

  • [Journal Article] Characterization of the radiolabeled metabolite of tau PET tracer 18F-THK53512016
    • Author(s)
      Harada R, Furumoto S, Tago T, Furukawa K, Ishiki A, Tomita N, Iwata R, Tashiro M, Arai H, Yanai K, Kudo Y, Okamura N.
    • Journal Title

      European Journal of Nuclear Medicine and Molecular Imaging

      Volume: 43 Pages: 2211-2218

    • DOI

      10.1007/s00259-016-3453-y

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PLANNED-26117003, KAKENHI-PROJECT-15H04900, KAKENHI-PROJECT-15K19767, KAKENHI-PROJECT-16K15570

  • [Journal Article] [18F]THK-5117 PET for assessing neurofibrillary pathology in Alzheimer's disease.2015
    • Author(s)
      Harada R, Okamura N, Furumoto S, Furukawa K, Ishiki A, Tomita N, Hiraoka K, Watanuki S, Shidahara M, Miyake M, Ishikawa Y, Matsuda R, Inami A, Yoshikawa T, Tago T, Funaki Y, Iwata R, Tashiro M, Yanai K, Arai H, Kudo Y.
    • Journal Title

      Eur J Nucl Med Mol Imaging

      Volume: -

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PLANNED-26117003

  • [Journal Article] Histamine H3 Receptor in Primary Mouse Microglia Inhibits Chemotaxis, Phagocytosis and Cytokine Secretion2015
    • Author(s)
      Iida T, Yoshikawa T, Matsuzawa T, Naganuma F, Nakamura T, Miura Y, Mohsen AS, Harada R, Iwata R, Yanai K.
    • Journal Title

      Glia.

      Volume: 印刷中 Pages: 1213-1225

    • DOI

      10.1002/glia.22812

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-221S0003, KAKENHI-PROJECT-15K20028, KAKENHI-PROJECT-26253016, KAKENHI-PROJECT-14J07936, KAKENHI-PROJECT-26830041

  • [Journal Article] 11. Longitudinal Assessment of Tau Pathology in Patients with Alzheimer's Disease Using [18F]THK-5117 Positron Emission Tomography.2015
    • Author(s)
      Ishiki, Aiko Okamura, Nobuyuki Furukawa, Katsutoshi Furumoto, Shozo Harada, Ryuichi Tomita, Naoki Hiraoka, Kotaro Watanuki, Shoichi Ishikawa, Yoichi Tago, Tetsuro Funaki, Yoshihito Iwata, Ren Tashiro, Manabu Yanai, Kazuhiko Kudo, Yukitsuka Arai, Hiroyuki
    • Journal Title

      PLoS One.

      Volume: 10 Pages: 1-9

    • DOI

      10.1371/journal.pone.0140311

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15K08127, KAKENHI-PROJECT-15K15268, KAKENHI-PLANNED-26117003, KAKENHI-PROJECT-15H04900, KAKENHI-PROJECT-14J06908, KAKENHI-PROJECT-25670525

  • [Journal Article] Role of histamine H3 receptor in glucagon-secreting αTC1.6 cells.2015
    • Author(s)
      Tadaho Nakamura, Takeo Yoshikawa, Fumito Naganuma, Attyeb Mohsen, Tomomitsu iida, Yamato Miura, Akira Sugawara and Kazuhiko Yanai
    • Journal Title

      FEBS Open Bio.

      Volume: 5 Pages: 36-41

    • DOI

      10.1016/j.fob.2014.12.001

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-14J07936, KAKENHI-PROJECT-25461381, KAKENHI-PLANNED-26117003, KAKENHI-PROJECT-26253016, KAKENHI-PROJECT-26670117, KAKENHI-PROJECT-26830041

  • [Journal Article] [(18)F]THK-5117 PET for assessing neurofibrillary pathology in Alzheimer's disease.2015
    • Author(s)
      Harada R, Furukawa K, et al.
    • Journal Title

      European Journal of Nuclear Medicine and Molecular Imaging

      Volume: 42 Pages: 1052-1061

    • DOI

      10.1007/s00259-015-3035-4

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-24390179, KAKENHI-PROJECT-15K15268, KAKENHI-PROJECT-15K15444, KAKENHI-PLANNED-26117003, KAKENHI-PROJECT-26253016, KAKENHI-PROJECT-15H04900, KAKENHI-PROJECT-25670525, KAKENHI-PROJECT-26830041, KAKENHI-PROJECT-25293257

  • [Journal Article] Amyloid deposits and response to shunt surgery in idiopathic normal-pressure hydrocephalus.2015
    • Author(s)
      Hiraoka, Kotaro Narita, Wataru Kikuchi, Hirokazu Baba, Toru Kanno, Shigenori Iizuka, Osamu Tashiro, Manabu Furumoto, Shozo Okamura, Nobuyuki Furukawa, Katsutoshi Arai, Hiroyuki Iwata, Ren Mori, Etsuro Yanai, Kazuhiko
    • Journal Title

      Journal of the Neurological Sciences

      Volume: 356 Pages: 124-128

    • DOI

      10.1016/j.jns.2015.06.029

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15K08127, KAKENHI-PROJECT-15K15268, KAKENHI-PLANNED-26117003, KAKENHI-PROJECT-26253016, KAKENHI-PROJECT-25670525

  • [Journal Article] Brain histamine H1 receptor occupancy measured by PET after oral administration of levocetirizine, a non-sedating antihistamine.2015
    • Author(s)
      Hiraoka K, Tashiro M, Grobosch T, Maurer M, Oda K, Toyohara J, Ishii K, Ishiwata K, Yanai K.
    • Journal Title

      Expert Opin Drug Saf.

      Volume: 14 Pages: 199-206

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25670525

  • [Journal Article] [(18)F]THK-5117 PET for assessing neurofibrillary pathology in Alzheimer's disease.2015
    • Author(s)
      Harada R, Okamura N, Furumoto S, Furukawa K, Ishiki A, Tomita N, Hiraoka K, Watanuki S, Shidahara M, Miyake M, Ishikawa Y, Matsuda R, Inami A, Yoshikawa T, Tago T, Funaki Y, Iwata R, Tashiro M, Yanai K, Arai H, Kudo Y.
    • Journal Title

      Eur J Nucl Med Mol Imaging

      Volume: 1 Pages: 1-2

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25670525

  • [Journal Article] Insufficient intake of L-histidine reduces brain histamine and causes anxiety-like behaviors in male mice.2015
    • Author(s)
      Takeo Yoshikawa, Tadaho Nakamura, Testuro Shibakusa, Mayu Sugita, Fumito Naganuma, Tomomitsu Iida, Yamato Miura, Attayeb Mohsen, Ryuichi Harada, and Kazuhiko Yanai
    • Journal Title

      J Nutr.

      Volume: 144 Pages: 1637-1641

    • DOI

      10.3945/jn.114.196105

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-14J07936, KAKENHI-PROJECT-221S0003, KAKENHI-PLANNED-26117003, KAKENHI-PROJECT-26253016, KAKENHI-PROJECT-26670117, KAKENHI-PROJECT-26830041

  • [Journal Article] Quantitative kinetic analysis of PET amyloid imaging agents [11C]BF227 and [18F]FACT in human brain.2015
    • Author(s)
      Shidahara M, Watabe H, Tashiro M, Okamura N, Furumoto S, Watanuki S, Furukawa K, Arakawa Y, Funaki Y, Iwata R, Gonda K, Kudo Y, Arai H, Ishiwata K, Yanai K.
    • Journal Title

      Nucl Med Biol

      Volume: 42 Pages: 734-44

    • DOI

      10.1016/j.nucmedbio.2015.05.001

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15K15268, KAKENHI-PROJECT-15K15444, KAKENHI-PLANNED-26117003, KAKENHI-PROJECT-26253016, KAKENHI-PROJECT-25670525, KAKENHI-PROJECT-25293257, KAKENHI-PROJECT-26293133

  • [Journal Article] Brain histamine H1 receptor occupancy measured by PET after oral administration of levocetirizine, a non-sedating antihistamine.2015
    • Author(s)
      Hiraoka K, Tashiro M, Grobosch T, Maurer M, Oda K, Toyohara J, Ishii K, Ishiwata K, Yanai K.
    • Journal Title

      Expert Opin Drug Saf.

      Volume: 14 Pages: 199-206

    • DOI

      10.1517/14740338.2015.989831

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-25861059, KAKENHI-PLANNED-26117003, KAKENHI-PROJECT-26253016, KAKENHI-PROJECT-25670525

  • [Journal Article] Structural abnormality of the hippocampus associated with depressive symptoms in heart failure rats2015
    • Author(s)
      Suzuki H, Sumiyoshi A, Matsumoto Y, Duffy BA, Yoshikawa T, Lythgoe MF, Yanai K, Taki Y, Kawashima R, Shimokawa H.
    • Journal Title

      NeuroImage

      Volume: 105 Pages: 84-92

    • DOI

      10.1016/j.neuroimage.2014.10.040

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-25893010, KAKENHI-PROJECT-26253016, KAKENHI-PROJECT-26830041, KAKENHI-PROJECT-15K19362

  • [Journal Article] Histamine H1 receptor occupancy by the new-generation antipsychotics olanzapine and quetiapine: a positron emission tomography study in healthy volunteers.2015
    • Author(s)
      Sato, Hirotoshi Ito, Chihiro Hiraoka, Kotaro Tashiro, Manabu Shibuya, Katsuhiko Funaki, Yoshihito Yoshikawa, Takeo Iwata, Ren Matsuoka, Hiroo Yanai, Kazuhiko
    • Journal Title

      Psychopharmacol.

      Volume: 232 Pages: 3497-3505

    • DOI

      10.1007/s00213-015-4002-2

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K08127, KAKENHI-PROJECT-26253016, KAKENHI-PROJECT-25670525, KAKENHI-PROJECT-26830041, KAKENHI-PROJECT-25293257

  • [Journal Article] [18F]THK-5117 PET for assessing neurofibrillary pathology in Alzheimer's disease2015
    • Author(s)
      Harada R, Okamura N, Furumoto S, Furukawa K, Ishiki A, Tomita N, Hiraoka K, Watanuki S, Shidahara M, Miyake M, Ishikawa Y, Matsuda R, Inami A, Yoshikawa T, Tago T, Funaki Y, Iwata R, Tashiro M, Yanai K, Arai H, Kudo Y.
    • Journal Title

      Eur J Nucl Med Mol Imaging.

      Volume: 印刷中

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26253016

  • [Journal Article] Noninvasive assessment of Alzheimer’s disease neurofibrillary pathology using 18F-THK5105 PET.2014
    • Author(s)
      Nobuyuki Okamura, Shozo Furumoto, Michelle T. Fodero-Tavoletti, Rachel S. Mulligan, Ryuichi Harada, Paul Yates, Svetlana Pejoska, Yukitsuka Kudo, Colin L. Masters, Kazuhiko Yanai, Christopher C. Rowe, Victor L. Villemagne
    • Journal Title

      Brain

      Volume: 137 Pages: 1762-1771

    • DOI

      10.1093/brain/awu064

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-12J07785, KAKENHI-PROJECT-25670524, KAKENHI-PLANNED-26117003, KAKENHI-PROJECT-26253016

  • [Journal Article] Imaging of amyloid deposition in human brain using positron emission tomography and [18F]FACT: comparison with [11C]PIB.2014
    • Author(s)
      Ito H, Shinotoh H, Shimada H, Miyoshi M, Yanai K, Okamura N, Takano H, Takahashi H, Arakawa R, Kodaka F, Ono M, Eguchi Y, Higuchi M, Fukumura T, Suhara T.
    • Journal Title

      Eur J Nucl Med Mol Imaging

      Volume: 41 Pages: 745-754

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26253016

  • [Journal Article] Pitfalls of voxel-based amyloid PET analyses for diagnosis of Alzheimer's disease: artifacts due to non-specific uptake in the white matter and the skull.2014
    • Author(s)
      Arai A, Kaneta T, Okamura N, Tashiro M, Iwata R, Takanami K, Fukuda H, Takahashi S, Yanai K, Kudo Y, Arai H.
    • Journal Title

      Tohoku J Exp Med.

      Volume: 234 Pages: 175-181

    • NAID

      130004694506

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25670525

  • [Journal Article] Pitfalls of voxel-based amyloid PET analyses for diagnosis of Alzheimer's disease: artifacts due to non-specific uptake in the white matter and the skull.2014
    • Author(s)
      Arai A, Kaneta T, Okamura N, Tashiro M, Iwata R, Takanami K, Fukuda H, Takahashi S, Yanai K, Kudo Y, Arai H.
    • Journal Title

      Tohoku J Exp Med

      Volume: 234 Pages: 175-181

    • NAID

      130004694506

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-26117003

  • [Journal Article] Mechanism of the histamine H3 receptor-mediated increase in exploratory locomotor activity and anxiety-like behaviours in mice.2014
    • Author(s)
      Mohsen A, Yoshikawa T, Miura Y, Nakamura T, Naganuma F, Shibuya K, Iida T, Harada R, Okamura N, Watanabe T, Yanai K.
    • Journal Title

      Neuropharmacology.

      Volume: 81 Pages: 188-194

    • DOI

      10.1016/j.neuropharm.2014.02.003

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-24659255, KAKENHI-PROJECT-24790527, KAKENHI-PLANNED-26117003, KAKENHI-PROJECT-26253016, KAKENHI-PROJECT-26670117, KAKENHI-PROJECT-26830041

  • [Journal Article] Coffee treatment prevents the progression of sarcopenia in aged mice in vivo and in vitro2014
    • Author(s)
      Guo Y, Furukawa K, et al.
    • Journal Title

      Exp Gerontol

      Volume: 50 Pages: 1-8

    • DOI

      10.1016/j.exger.2013.11.005

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-24390179, KAKENHI-PROJECT-24659255

  • [Journal Article] The expression and function of histamine H3 Receptor in Pancreatic 13-cells2014
    • Author(s)
      Nakamura T, Yoshikawa T, Noguchi N, Sugawara A, Kasajima A, Sasano H, Yanai K.
    • Journal Title

      Br. J. Pharmacol

      Volume: 171 (1) Pages: 171-85

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24659255

  • [Journal Article] Synthesis and preliminary evaluation of 2-arylhydroxyquinoline derivatives for tau imaging.2014
    • Author(s)
      Tetsuro Tago, Shozo Furumoto, Nobuyuki Okamura, Ryuichi Harada, Yoichi Ishikawa, Hiroyuki Arai, Kazuhiko Yanai, Ren Iwata, Yhkitsuka Kudo
    • Journal Title

      J Labelled Comp Radiopharm.

      Volume: 57 Pages: 18-24

    • DOI

      10.1002/jlcr.3133

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-12J07785, KAKENHI-PROJECT-23390297, KAKENHI-PROJECT-24659255, KAKENHI-PROJECT-25293257, KAKENHI-PROJECT-25461870, KAKENHI-PROJECT-25670523, KAKENHI-PROJECT-25670524

  • [Journal Article] Use of a Benzimidazole Derivative BF-188 in Fluorescence Multispectral Imaging for Selective Visualization of Tau Protein Fibrils in the Alzheimer's Disease Brain2014
    • Author(s)
      Harada R, Okamura N, Furumoto S, Yoshikawa T, Arai H, Yanai K, Kudo Y.
    • Journal Title

      Mol Imaging Biol

      Volume: 16(1) Pages: 19-27

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24659255

  • [Journal Article] Analysis of early phase [11C]BF-227 PET, and its application for anatomical standardization of late-phase images for 3D-SSP analysis.2014
    • Author(s)
      Kaneta T, Okamura N, Arai A, Takanami K, Furukawa K, Tashiro M, Furumoto S, Iwata R, Takahashi S, Arai H, Y anai K, Kudo Y
    • Journal Title

      Jpn J Radiol

      Volume: 32 Issue: 3 Pages: 138-144

    • DOI

      10.1007/s11604-013-0276-7

    • NAID

      50009030775

    • ISSN
      1867-1071, 1867-108X
    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-23390297, KAKENHI-PROJECT-24390179, KAKENHI-PROJECT-24591745, KAKENHI-PROJECT-24659255, KAKENHI-PROJECT-25670524, KAKENHI-PROJECT-25670525, KAKENHI-PROJECT-26253016

  • [Journal Article] In vivo evaluation of a novel tau imaging tracer for Alzheimer's disease.2014
    • Author(s)
      Villemagne L. Victor, Shozo Furumoto, Michelle T. Fodero-Tavoletti, Rachel S. Mulligan, John Hodges, Ryuichi Harada, Paul Yates, Oliver Piguet, Svetlana Pejoska, Vincent Doré, Kazuhiko Yanai, Colin L. Masters, Yukitsuka Kudo, Christopher C. Rowe, Nobuyuki Okamura.
    • Journal Title

      Eur J Nucl Med Mol Imaging.

      Volume: 41 Pages: 18-24

    • DOI

      10.1007/s00259-013-2681-7

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-12J07785, KAKENHI-PROJECT-23390297, KAKENHI-PROJECT-24659255, KAKENHI-PROJECT-25293259, KAKENHI-PROJECT-25670524, KAKENHI-PLANNED-26117003, KAKENHI-PROJECT-26253016

  • [Journal Article] Pitfalls of voxel-based amyloid PET analyses for diagnosis of Alzheimer's disease: artifacts due to non-specific uptake in the white matter and the skull.2014
    • Author(s)
      Arai A, Kaneta T, Okamura N, Tashiro M, Iwata R, Takanami K, Fukuda H, Takahashi S, Yanai K, Kudo Y, Arai H.
    • Journal Title

      Tohoku J Exp Med

      Volume: 234 Pages: 175-181

    • NAID

      130004694506

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26253016

  • [Journal Article] Predominant role of plasma membrane monoamine transporters in monoamine transport in 1321N1, a human astrocytoma-derived cell line.2014
    • Author(s)
      Fumito Naganuma, Takeo Yoshikawa, Tadaho Nakamura, Tomomistu Iida, Ryuichi Harada, Attayeb S. Mohsen, Yamato Miura and Kazuhiko Yanai.
    • Journal Title

      J Neurochem.

      Volume: 129 Pages: 591-601

    • DOI

      10.1111/jnc.12665

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-14J07936, KAKENHI-PROJECT-221S0003, KAKENHI-PROJECT-24659255, KAKENHI-PLANNED-26117003, KAKENHI-PROJECT-26253016, KAKENHI-PROJECT-26670117, KAKENHI-PROJECT-26830041

  • [Journal Article] Non-invasive assessment of Alzheimer's disease neurofibrillary pathology using 18F-THK5105 PET2014
    • Author(s)
      Okamura N, Furumoto S, Fodero-Tavoletti MT, Mulligan RS, Harada R, Yates P, Pejoska S, Kudo Y, Masters CL, Yanai K, Rowe CC, Villemagne VL.
    • Journal Title

      Brain

      Volume: (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24659255

  • [Journal Article] Imaging of amyloid deposition in human brain using positron emission tomography and [18F]FACT : comparison with [ 11C]PIB2014
    • Author(s)
      Ito H, Shinotoh H, Shimada H, Miyoshi M, Yanai K, Okamura N, Takano H, Takahashi H, Arakawa R, Kodaka F, Ono M, Eguchi Y, Higuchi M, Fukumura T, Suhara T.
    • Journal Title

      Eur J Nucl Med Mol Imaging

      Volume: 41(4) Pages: 745-54

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24659255

  • [Journal Article] Tau PET imaging in Alzheimer’s disease.2014
    • Author(s)
      Nobuyuki Okamura, Ryuichi Harada, Shozo Furumoto, Hiroyuki Arai, Kazuhiko Yanai, Yukistsuka Kudo,
    • Journal Title

      Curr Neurol Neurosci Rep.

      Volume: 14 Pages: 500-500

    • DOI

      10.1007/s11910-014-0500-6

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-14J06908, KAKENHI-PROJECT-25670524, KAKENHI-PLANNED-26117003, KAKENHI-PROJECT-26253016

  • [Journal Article] Assessing THK523 selectivity for tau deposits in Alzheimer's disease and non Alzheimer's disease tauopathies2014
    • Author(s)
      Michelle T. Fodero-Tavoletti, Shozo Furumoto, Leanne Taylor, Catriona A McLean, Rachel S Mulligan, Ian Birchall, Ryuichi Harada, Colin L Masters, Kazuhiko Yanai, Yukitsuka Kudo, Christopher C Rowe, Nobuyuki Okamura, Victor L Villemagne
    • Journal Title

      Alzheimers Res Ther

      Volume: 6 Pages: 11-11

    • DOI

      10.1186/alzrt240

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-12J07785, KAKENHI-PROJECT-24659255

  • [Journal Article] ヒスタミンの生理作用 : "善玉"としてのヒスタミン2013
    • Author(s)
      飯田智光、三浦大和、長沼史登、中村正帆、吉川雄朗、谷内一彦
    • Journal Title

      皮膚アレルギーフロンティア

      Volume: vol.11 Pages: 65-70

    • Data Source
      KAKENHI-PROJECT-24659255

  • [Journal Article] Histamine H1 receptor occupancy by the new-generation antidepressants fluvoxamine and mirtazapine: a positron emission tomography study in healthy volunteers.2013
    • Author(s)
      Sato H, Ito C, Tashiro M, Hiraoka K, Shibuya K, Funaki Y, Iwata R, Matsuoka H, Yanai K.
    • Journal Title

      Psychopharmacology (Berl).

      Volume: 230 (2) Pages: 227-234

    • DOI

      10.1007/s00213-013-3146-1

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24659255, KAKENHI-PROJECT-25670525, KAKENHI-PROJECT-25861059

  • [Journal Article] Evaluation of the biodistribution and radiation dosimetry of the 18F-labelled amyloid imaging probe [18F]FACT in humans2013
    • Author(s)
      Shidahara M, Tashiro M, Okamura N, Furumoto S, Furukawa K, Watanuki S, Hiraoka K, Miyake M, Iwata R, Tamura H, Arai H, Kudo Y, Y anai K
    • Journal Title

      EJNMMI Res.

      Volume: 3 Pages: 32-32

    • DOI

      10.1186/2191-219x-3-32

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390297, KAKENHI-PROJECT-24659255, KAKENHI-PROJECT-25293257, KAKENHI-PROJECT-25670525, KAKENHI-PROJECT-25861059

  • [Journal Article] Comparison of the binding characteristics of [18F]THK-523 and other2013
    • Author(s)
      Ryuichi Harada
    • Journal Title

      European Journal of Nuclear Medicine

      Volume: 40 Pages: 125-132

    • DOI

      10.1007/s00259-012-2261-2

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-12J07785, KAKENHI-PROJECT-22390228, KAKENHI-PROJECT-23390235, KAKENHI-PROJECT-23390297, KAKENHI-PROJECT-23591735, KAKENHI-PROJECT-24659255, KAKENHI-PLANNED-23111009

  • [Journal Article] Novel 18F-labeled arylquinoline derivatives for noninvasive imaging of tau pathology in Alzheimer disease.2013
    • Author(s)
      Okamura N, Furumoto S, Harada R, Tago T, Y oshikawa T, Fodero-Tavoletti M, Mulligan RS, Villemagne VL, Akatsu H, Y amamoto T, Arai H, Iwata R, Y anai K, Kudo Y
    • Journal Title

      J Nucl Med.

      Volume: 54 Pages: 1420-1427

    • DOI

      10.2967/jnumed.112.117341

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390297, KAKENHI-PROJECT-24659255, KAKENHI-PROJECT-25670524

  • [Journal Article] Roles played by histamine in strenuous or prolonged masseter muscle activity in mice2013
    • Author(s)
      Yoneda H, Niijima-Yaoita F, Tsuchiya M, Kumamoto H, Watanabe M, Ohtsu H, Yanai K, Tadano T, Sasaki K, Sugawara S, Endo Y.
    • Journal Title

      Clin. Exp. Pharmacol. Physiol.

      Volume: 40 Pages: 848-55

    • DOI

      10.1111/1440-1681.12167

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390439, KAKENHI-PROJECT-24390429, KAKENHI-PROJECT-24592826, KAKENHI-PROJECT-24659255, KAKENHI-PROJECT-24700433, KAKENHI-PROJECT-25670813

  • [Journal Article] 『記録「日本薬理学会・日本臨床薬理学会共催シンポジウム：遺伝子・組織バンクと医療情報の電子化」座長のまとめ』2013
    • Author(s)
      篠栗俊之・谷内一彦
    • Journal Title

      臨床薬理

      Volume: 44巻2号 Pages: 171-172

    • Data Source
      KAKENHI-PROJECT-24243017

  • [Journal Article] Royal jelly prevents the progression of sarcopenia in aged mice in vivo and in vitro.2013
    • Author(s)
      Kaijun Niu, Hui Guo, Yinting Guo, Satoru Ebihara, Masanori Asada, Takashi Ohrui, Katsutoshi Furukawa, Masakazu Ichinose,Kazuhiko Yanai, Yukitsuka Kudo, Hiroyuki Arai, Tatsuma Okazaki, and Ryoichi Nagatomi
    • Journal Title

      J Gerontol A Biol Sci Med Sci

      Volume: (掲載確定) Pages: 1482-1492

    • DOI

      10.1093/gerona/glt041

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23890018, KAKENHI-PROJECT-24300187, KAKENHI-PROJECT-24659255, KAKENHI-PROJECT-24659397

  • [Journal Article] In vitro and in vivo characterization of 2-deoxy-2-18F-fluoro-D-mannose as a tumor-imaging agent for PET.2013
    • Author(s)
      Furumoto S, Shinbo R, Iwata R, Ishikawa Y, Ynai K, Yoshioka T, Fukuda H
    • Journal Title

      J. Nucl. Med. Mol. Imag.

      Volume: 54 Pages: 1354-1361

    • DOI

      10.2967/jnumed.112.113571

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22300345, KAKENHI-PROJECT-24659255, KAKENHI-PROJECT-25293257, KAKENHI-PROJECT-25461870, KAKENHI-PROJECT-25670523

  • [Journal Article] A 18 F-Labeled BF-227 Derivative as a Potential Radioligand for Imaging Dense Amyloid Plaques by Positron Emission Tomography2013
    • Author(s)
      Shozo Furumoto
    • Journal Title

      Mol Imaging Biol.

      Volume: 15 Pages: 497-506

    • DOI

      10.1007/s11307-012-0608-5

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-12J07785, KAKENHI-PROJECT-23390297, KAKENHI-PROJECT-24659255, KAKENHI-PROJECT-25293257, KAKENHI-PROJECT-25461870, KAKENHI-PROJECT-25670523, KAKENHI-PROJECT-25670524, KAKENHI-PROJECT-25670525

  • [Journal Article] Molecular mechanism of histamine clearance by primary human astrocytes.2013
    • Author(s)
      Yoshikawa T, Naganuma F, Iida T, Nakamura T, Harada R, Mohsen A, Kasajima A, Sasano H, Yanai K
    • Journal Title

      Glia

      Volume: 61 Pages: 905-16

    • DOI

      10.1002/glia.22484

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-221S0003, KAKENHI-PROJECT-24659255

  • [Journal Article] 「抗ヒスタミン薬はなぜ眠気を誘発するのか?」「数多く存在する抗ヒスタミン薬はどのように分類して考えればよいのか?」「抗ヒスタミン薬同士の併用は意味があるのか?」2013
    • Author(s)
      長沼史登、谷内一彦
    • Journal Title

      抗ヒスタミン薬 : 達人の処方箋メディカルレビュー社

      Pages: 301-301

    • Data Source
      KAKENHI-PROJECT-24659255

  • [Journal Article] Brain accumulation of amyloid 13 protein visualized by positron emission tomography and BF-227 in Alzheimer's disease patients with or without diabetes mellitus2013
    • Author(s)
      Tomita N, Furukawa K, Okamura N, Tashiro M, Une K, Furumoto S, Iwata R, Y anai K, Kudo Y, Arai H
    • Journal Title

      Geriatr Gerontol Int

      Volume: 13 Pages: 215-21

    • DOI

      10.1111/j.1447-0594.2012.00880.x

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390297, KAKENHI-PROJECT-24659255

  • [Journal Article] Effects of Preceding Stimulation on Brain Activation in Response to Colonic Distention in Humans2013
    • Author(s)
      Hamaguchi T, Kano M, Kanazawa M, Itoh M, Yanai K, Fukudo S.
    • Journal Title

      Psychosom Med

      Volume: 75(5) Pages: 453-62

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24659255

  • [Journal Article] 非鎮静性抗ヒスタミン薬の薬理学的特徴2013
    • Author(s)
      中村正帆、長沼史登、谷内一彦、吉川雄朗
    • Journal Title

      アレルギーの臨床

      Volume: 33 Pages: 22-26

    • Data Source
      KAKENHI-PROJECT-24659255

  • [Journal Article] A F18-Labeled BF-227 Derivative as a Potential Radioligand for Imaging Dense Amyloid Plaques by Positron Emission Tomography.2013
    • Author(s)
      Furumoto S, Okamura N, Furukawa K, Tashiro M, Ishikawa Y, Sugi K, Tomita N, Waragai M, Harada R, Tago T, Iwata R, Yanai K, Arai H, Kudo Y.
    • Journal Title

      Mol Imaging Biol.

      Volume: in press

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24659255

  • [Journal Article] Safety considerations in the management of allergic diseases : focus on antihistamines2012
    • Author(s)
      Yanai K, Rogala B, Chugh K, Paraskakis E, Pampura AN, Boev R
    • Journal Title

      Current Medical Research & Opinion

      Volume: Vol.28 (4)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390171

  • [Journal Article] Cholinergic deficit and response to donepezil therapy in Parkinson's disease with dementia2012
    • Author(s)
      Hiraoka K, Okamura N, Funaki Y, Hayashi A, Tashiro M, Hisanaga K, Fujii T, Takeda A, Yanai K, Iwata R, Mori E.
    • Journal Title

      Eur Neurol

      Volume: 68(3) Pages: 137-43

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24659255

  • [Journal Article] Effects of presence of a familiar pet dog on regional cerebral activity in healthy volunteers : a positron emission tomography study2012
    • Author(s)
      Sugawara A, Masud MM, Yokoyama A, Mizutani W, Watanuki S, Yanai K, Itoh M, Tashiro M
    • Journal Title

      Anthrozoos

      Volume: Vol.25 Pages: 25-34

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590754

  • [Journal Article] [11C] Doxepin binding to histamine H1 receptors in living human brain in association with attentive waking and circadian rhythm2012
    • Author(s)
      Shibuya K, Funaki Y, Hiraoka K, Yoshikawa T, Miyake M, Watanuki S, Shao H, Tashiro M, Yanai K
    • Journal Title

      Frontiers in Systems Neuroscience

      Volume: (印刷中)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590754

  • [Journal Article] Synthesis of [11C]interleukin 8 using a cell-free translation system and L-[11C]methionine.2012
    • Author(s)
      Harada R, Furumoto S, Y oshikawa T, Ishikawa Y, Shibuya K, Okamura N, Iwata R, Y anai K
    • Journal Title

      Nuclear Medicine and Biology

      Volume: 39 Pages: 155-160

    • DOI

      10.1016/j.nucmedbio.2011.07.005

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390297, KAKENHI-PROJECT-23650610, KAKENHI-PROJECT-23791387, KAKENHI-PROJECT-24659255

  • [Journal Article] [(11)C]Doxepin binding to histamine H1 receptors in living human br ain: reproducibility during attenti ve waking and circadian rhythm2012
    • Author(s)
      KatsuhikoShibuya
    • Journal Title

      Front Synt Neurosci

      Volume: 6 Pages: 45-45

    • DOI

      10.3389/fnsys.2012.00045

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23791388, KAKENHI-PROJECT-24659255, KAKENHI-PROJECT-24790527

  • [Journal Article] 日本をリードするPET橋渡し研究拠点 : 東北大学サイクロトロン・ラジオアイソトーフ。センター2012
    • Author(s)
      古本祥三、田代学、岩田錬、谷内一彦
    • Journal Title

      PET Joumal

      Volume: 18 Pages: 4-6

    • Data Source
      KAKENHI-PROJECT-24659255

  • [Journal Article] Cardiac positron-emission tomography images with an amyloid-specific tracer in familial transthyretin-related systemic amyloidosis2012
    • Author(s)
      Furukawa K, Ikeda S, Okamura N, Tashiro M, T omita N, Furumoto S, Iwata R, Y anai K, Kudo Y, Arai H
    • Journal Title

      Circulation

      Volume: 125 Pages: 556-557

    • DOI

      10.1161/circulationaha.111.045237

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390297, KAKENHI-PROJECT-24659255

  • [Journal Article] Anticholinergic activity of antihistamines2012
    • Author(s)
      Yanai K
    • Journal Title

      Clin Neurophysiol

      Volume: 123(4) Pages: 633-4

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390171

  • [Journal Article] Roles of histamine in exercise-induced fatigue : favouring endurance and protecting against exhaustion2012
    • Author(s)
      Niijima-Yaoita F, Tsuchiya M, Ohtsu H, Yanai K, Sugawara S, Endo Y, Tadano T.
    • Journal Title

      Biol Pharm Bull

      Volume: 35(1) Pages: 91-7

    • NAID

      130001872348

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24659255

  • [Journal Article] Rapid biochemical synthesis of (11)C-labeled single chain variable fragment antibody for immuno-PET by cell-free protein synthesis.2012
    • Author(s)
      Matsuda T., Furumoto S., Higuchia K., Yokoyama J., Zhang M.-R., Yanai K., Iwatad R., Kigawa T.
    • Journal Title

      Bioorg Med Chem.

      Volume: 20 Pages: 6579-6582

    • DOI

      10.1016/j.bmc.2012.09.038

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390228, KAKENHI-PROJECT-23791387, KAKENHI-PROJECT-24659255, KAKENHI-PLANNED-23119005

  • [Journal Article] Roles of histamine in exercise-induced fatigue : favouring endurance and protecting against exhaustion2012
    • Author(s)
      Niijima-Yaoita F, Tsuchiya M, Ohtsu H, Yanai K, Sugawara S, Endo Y, Tadano T
    • Journal Title

      Biol Pharm Bull

      Volume: 35(1) Pages: 91-7

    • NAID

      130001872348

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390171

  • [Journal Article] The hydrophobic amino acids in putative helix 8 in carboxy-terminus of histamine H3 receptor are involved in receptor-G-protein coupling2011
    • Author(s)
      Kuramasu A, Sukegawa J, Sato T, Sakurai E, Watanabe T, Yanagisawa T, Yanai K
    • Journal Title

      Cell Signal

      Volume: 23(11) Pages: 1843-1843

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390171

  • [Journal Article] Brain histamine H1 receptor occupancy of loratadine measured by PET : Comparison of H1 receptor occupancy and proportional impairment ratio2011
    • Author(s)
      Kubo N, Senda M, Ohsumi Y, Sakamoto S, Matsumoto K, Tashiro M, Okamura N, Yanai K
    • Journal Title

      Hum Psychopharmacol

      Volume: 26(2) Pages: 133-139

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390171

  • [Journal Article] The hydrophobic amino acids in putative helix 8 in carboxy-terminus of histamine H(3) receptor are involved in receptor-G-protein coupling2011
    • Author(s)
      Kuramasu A, Sukegawa J, Sato T, Sakurai E, Watanabe T, Yanagisawa T, Yanai K.
    • Journal Title

      Cell Signal

      Volume: Nov ; 23(11) Pages: 1843-9

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590268

  • [Journal Article] A modified method of 3D-SSP analysis for amyloid PET imaging using[^<11>C]BF-2272011
    • Author(s)
      Kaneta T, Okamuia N, Minoshima S, Furukawa K, Tashiro M, Furumoto S, Iwata R, Fukuda H, Takahashi S, Yanai K, Kudo Y, Arai H
    • Journal Title

      Ann Nucl Med

      Volume: 25 Pages: 643-649

    • DOI

      10.1007/s12149-011-0518-7

    • NAID

      10030233510

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590754, KAKENHI-PROJECT-22390228, KAKENHI-PROJECT-23390297

  • [Journal Article] Regional cerebral metabolic changes in patients with neck pain following chiropractic spinal manipulation : [18F] FDG PET Analysis2011
    • Author(s)
      Ogura T, Tashiro M, Masud M, Watanuki S, Shibuya K, Yamaguchi K, Itoh M, Fukuda H, Yanai K
    • Journal Title

      Altern Ther Health Med.

      Volume: 17(確認中) Pages: 12-17

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590754

  • [Journal Article] Positron emission tomography evaluation of sedative properties of antihistamines2011
    • Author(s)
      Yanai K, Zhang D, Tashiro M, Yoshikawa T, Naganuma F, Harada R, Nakamura T, Shibuya K, Okamura N
    • Journal Title

      Expert Opinion on Drug Safety

      Volume: 10(4) Pages: 613-613

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390171

  • [Journal Article] PET Evaluation of Sedative Properties of Antihistamines.2011
    • Author(s)
      Yanai K, et al.
    • Journal Title

      Expert Opinion on Drug Safety

      Volume: (未定,印刷中)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390171

  • [Journal Article] Effects of presence of a familiar pet dog on regional cerebral activity in healthy volunteers : a positron emission tomography study2011
    • Author(s)
      Sugawara A, Masud MM, Yokoyama A, Mizutani W, Watanuki S, Yanai K, Itoh M, Tashiro M
    • Journal Title

      Anthrozoos

      Volume: (未定)(印刷中)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590754

  • [Journal Article] Regional cerebral metabolic changes in patients with neck pain following chiropractic spinal manipulation : [18F] FDG PET Analysis2011
    • Author(s)
      Ogura T, Tashiro M, Masud M, Watanuki S, Shibuya K, Yamaguchi K, Itoh M, Fukuda H, Yanai K
    • Journal Title

      Altern Ther Health Med

      Volume: Vol.17 Pages: 12-14

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590754

  • [Journal Article] Brain histamine H1 receptor occupancy of loratadine measured by PET : Comparison of H1 receptor occupancy and proportional impairment ratio2011
    • Author(s)
      Kubo N, Yanai K, et al
    • Journal Title

      Human Psychopharmacol

      Volume: 26(2) Pages: 133-139

    • DOI

      10.1002/hup.1184

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390171, KAKENHI-PROJECT-21590754

  • [Journal Article] Cerebral metabolic changes in men after chiropractic spinal manipulation for neck pain2011
    • Author(s)
      Ogura T, Tashiro M, Masud M, Watanuki S, Shibuya K, Yamaguchi K, Itoh M, Fukuda H, Yanai K.
    • Journal Title

      Ahern Ther Health Med

      Volume: 17(6) Pages: 12-7

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24659255

  • [Journal Article] Effects of a chicken extract on food-deprived activity stress in rats2011
    • Author(s)
      Lu YQ, He RR, Watanabe H, Abe K, Sakurai E, Yanai K, Kurihara H
    • Journal Title

      Biosci Biotechnol Biochem

      Volume: 74(6) Pages: 1276-1276

    • NAID

      10027556590

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390171

  • [Journal Article] The hydrophobic amino acids in putative helix 8 in carboxy-terminus of histamine H (3) receptor are involved in receptor-G-protein coupling2011
    • Author(s)
      Kuramasu A, Yanai K, et al
    • Journal Title

      Cellular Signalling

      Volume: 23(11) Pages: 1843-1849

    • DOI

      10.1016/j.cellsig.2011.06.021

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390171, KAKENHI-PROJECT-21590267, KAKENHI-PROJECT-23618003

  • [Journal Article] Alpha-fluoromethylhistidine, a histamine synthesis inhibitor, inhibits orexin-induced wakefulness in rats2011
    • Author(s)
      Seki Y, Akanmu MA, Matsuura M, Yanai K, Honda K
    • Journal Title

      Behav. Brain Res

      Volume: 207 Pages: 151-154

    • Data Source
      KAKENHI-PROJECT-21390171

  • [Journal Article] ヒスタミン受容体を理解する2011
    • Author(s)
      谷内一彦、長沼史登、中村正帆、吉川雄朗
    • Journal Title

      DermatologyToday

      Volume: 4 Pages: 4-9

    • Data Source
      KAKENHI-PROJECT-21390171

  • [Journal Article] Interaction of histamine and calcitonin gene-related peptide in the formalininduced pain perception in rats2011
    • Author(s)
      Mobarakeh JI, Torkaman-Boutorabi A, Rahimi AA, Ghasri S, Nezhad RM, Hamzely A, Khoshkholgh Sima B, Takahashi K, Nunoki K, Yanai K
    • Journal Title

      Biomed Res

      Volume: 32(3) Pages: 195-195

    • NAID

      130004470783

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390171

  • [Journal Article] 第二世代抗ヒスタミン薬の薬理学的特徴2011
    • Author(s)
      谷内一彦、長沼史登
    • Journal Title

      日本医事新報

      Volume: 4547 Pages: 57-59

    • Data Source
      KAKENHI-PROJECT-21390171

  • [Journal Article] Next-day Residual Sedative Effect after Nighttime Administration of an OTC Antihistamine Sleepaid, Diphenhydramine, Measured by Positron Emission Tomography2011
    • Author(s)
      Zhang D, Tashiro M, Shibuya K, Okamura N, Funaki Y, Yoshikawa T, Kato M, Yanai K
    • Journal Title

      J. Clin. Psychopharmacol

      Volume: 30(6) Pages: 694-701

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390171

  • [Journal Article] Positron emission tomography evaluation of sedative properties of antihistamines2011
    • Author(s)
      Yanai K, et al
    • Journal Title

      Expert Opin Drug Saf.

      Volume: 10(4) Pages: 613-622

    • DOI

      10.1517/14740338.2011.562889

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390171, KAKENHI-PROJECT-21590754, KAKENHI-PROJECT-23390297

  • [Journal Article] Roles of hypothalamic subgroup histamine and orexin neurons on behavioral responses to sleep deprivation induced by the treadmill method in adolescent rats2011
    • Author(s)
      Xu A, Sakurai E, Kuramasu A, Zhang J, Li J, Okamura N, Zhang D, Yoshikawa T, Watanabe T, Yanai K
    • Journal Title

      J. Pharmacol. Sci

      Volume: 114(4) Pages: 444-444

    • NAID

      10029891159

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390171

  • [Journal Article] Next-day Residual Sedative Effect after Nighttime Administration of an OTC Antihistamine Sleepaid, Diphenhydramine, Measured by Positron Emission Tomography.2010
    • Author(s)
      Zhang D, Yanai K, et al.
    • Journal Title

      J.Clin.Psychopharmacol.

      Volume: 30(6) Pages: 694-701

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390171

  • [Journal Article] 抗ヒスタミン薬の選択2010
    • Author(s)
      片山一郎、谷内一彦、Christpher Alford、Erwin Gelfand、Ian Hindmarch、幸野健、大久保公裕、Torsten Zuberbier
    • Journal Title

      最適な治療の視点からアレルギー・免疫

      Volume: 17 Pages: 456-468

    • Data Source
      KAKENHI-PROJECT-21390171

  • [Journal Article] In vivo detection of prion amyloid plaques using [(11)C]BF-227 PET.2010
    • Author(s)
      Okamura N, Shiga Y, Furumoto S, Tashiro M, Tsuboi Y, Furukawa K, Yanai K, Iwata R, Arai H, Kudo Y, Itoyama Y, Doh-Ura K.
    • Journal Title

      Eur J Nucl Med Mol Imaging. (未定, 印刷中)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590754

  • [Journal Article] Regional cerebral metabolic changes in patients with neck pain following chiropractic spinal manipulation : [18F]FDG PET Analysis2010
    • Author(s)
      Ogura T, Tashiro M, Masud M, Watanuki S, Shibuya K, Yamaguchi K, Itoh M, Fukuda H, Yanai K
    • Journal Title

      Altem Ther Health Med

      Volume: (未定)(印刷中)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590754

  • [Journal Article] Next-day residual sedative effect after nighttime administration of an over-the-counter antihistamine sleep aid, diphenhydramine, measured by positron emission tomography2010
    • Author(s)
      Zhang D, Tashiro M, Shibuya K, Okamura N, Funaki Y, Yoshikawa T, Kato M, Yanai K
    • Journal Title

      J Clin Psychopharmacol

      Volume: 30 Pages: 694-701

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590754

  • [Journal Article] Roles of hypothalamic subgroup histamine and orexin neurons on behavioral responses to sleep deprivation induced by the treadmill method in adolescent rats.2010
    • Author(s)
      Xu A, Yanai K, et al
    • Journal Title

      J.Pharmacol.Sci.

      Volume: 114(4) Pages: 444-453

    • NAID

      10029891159

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390171

  • [Journal Article] Alpha-fluoromethylhistidine, a histamine synthesis inhibitor, inhibits or exin-induced wakefulness in rats.2010
    • Author(s)
      Seki Y, Yanai K, et al.
    • Journal Title

      Behav.Brain Res.In press 2010 (印刷中)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21650088

  • [Journal Article] Amyloid PET in mild cognitive impairment and Alzheimer's disease with BF-227 : comparison to FDG-PET.2010
    • Author(s)
      Furukawa K, Okamura N, Tashiro M, Waragai M, Furumoto S, Iwata R, Yanai K, Kudo Y, Arai H.
    • Journal Title

      J Neurol. (未定, 印刷中)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590754

  • [Journal Article] In vivo visualization of alpha-synuclein deposition by carbon-11-labelled 2-[2-(2-dimethylaminothiazol-5-yl)ethenyl]-6-[2-(fluoro)ethoxy] benzoxazole positron emission tomography in multiple system atrophy2010
    • Author(s)
      Kikuchi A, Takeda A, Okamura N, Tashiro M, Hasegawa T, Furumoto S, Kobayashi M, Sugeno N, Baba T, Miki Y, Mori F, Wakabayashi K, Funaki Y, Iwata R, Takahashi S, Fukuda H, Arai H, Kudo Y, Yanai K, Itoyama Y
    • Journal Title

      Brain

      Volume: 133 Pages: 1772-1778

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590754

  • [Journal Article] In vivo detection of prion amyloid plaques using [(11)C]BF-227 PET2010
    • Author(s)
      Okamura N, Shiga Y, Furumoto S, Tashiro M, Tsuboi Y, Furukawa K, Yanai K, Iwata R, Arai H, Kudo Y, Itoyama Y, Doh-Ura K
    • Journal Title

      Eur J Nucl Med Mol Imaging

      Volume: 37 Pages: 934-941

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590754

  • [Journal Article] In vivo detection of prion amyloid plaques using [(11)C]BF-227 PET2010
    • Author(s)
      N.Okamura, Y.Shiga, S.Furumoto, M.Tashiro, Y.Tsuboi, K.Furukawa, K.Yanai, R.Iwata, H.Arai, Y.Kudo, Y.Itoyama, K.Doh-Ura
    • Journal Title

      Eur.J.Nucl.Med.Mol.Imag (In press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390311

  • [Journal Article] Voxel-based analysis of amyloid positron emission tomography probe[11C]BF-227 uptake in mild cognitive impairment and Alzheimer's disease2010
    • Author(s)
      Shao H, Okamura N, Sugi K, Furumoto S, Furukawa K, Tashiro M, Iwata R, Matsuda H, Kudo Y, Arai H, Fukuda H, Yanai K
    • Journal Title

      Dement Geriatr Cogn Disord

      Volume: 30 Pages: 101-111

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590754

  • [Journal Article] Long-tem performance evaluation of positron emission tomography : analysis and proposal of a maintenance protocol for long-term utilization2010
    • Author(s)
      Watanuki S, Tashiro M, Miyake M, Ishikawa Y, Itoh M, Yanai K, Sakemi Y, Fukuda H, Ishii K
    • Journal Title

      Ann Nucl Med

      Volume: 24 Pages: 461-468

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590754

  • [Journal Article] Roles of hypothalamic subgroup histamine and orexin neurons on behavioral responses to sleep deprivation induced by the treadmill method in adolescent rats2010
    • Author(s)
      Xu A, Sakurai E, Kuramasu A, Zhang J, Li J, Okamura N, Zhang D, Yoshikawa T, Watanabe T, Yanai K.
    • Journal Title

      J Pharmacol Sci

      Volume: 114(4) Pages: 444-53

    • NAID

      10029891159

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590268

  • [Journal Article] Alpha-fluoromethylhistidine, a histamine synthesis inhibitor, inhibits or exin-induced wakefulness in rats.2010
    • Author(s)
      Seki Y, Yanai K, et al.
    • Journal Title

      Behav.Brain Res.In press 2010 (In press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390171

  • [Journal Article]2010
    • Author(s)
      Tashiro M., Fujimoto T, Okamura N, Iwata R, Yanai K.
    • Journal Title

      Molecular and functional imaging for drug development and elucidation of disease mechanisms using positron emission tomography (PET). IN : Molecular Imaging for Integrated Medical Therapy and Drug Development(Ed. KUGE Yuji.)(Springer Japan)

      Pages: 222-234

    • Data Source
      KAKENHI-PROJECT-21590754

  • [Journal Article] 画像バイオマーカーとしての分子イメージングの利用:分子イメージングによる受容体占拠率の解析2010
    • Author(s)
      谷内一彦、吉川雄朗、古本祥三
    • Journal Title

      「創薬研究への分子イメージング応用」遺伝子MOOK18(佐治英郎編集メデイカルドゥ)

      Volume: 18 Pages: 133-139

    • Data Source
      KAKENHI-PROJECT-21650088

  • [Journal Article] In vivo detection of prion amyloid plaques using [(11)C]BF-227 PET2010
    • Author(s)
      N. Okamura, Y. Shiga, S. Furumoto, M. Tashiro, Y. Tsuboi, K. Furukawa, K. Yanai, R. Iwata, H. Arai, Y. Kudo, Y. Itoyama, K. Doh-Ura
    • Journal Title

      Eur.J.Nucl.Med.Mol.Imag. (印刷中)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390311

  • [Journal Article] 脳機能を標的とした新しい痒み治療戦略:痒みイメージング研究の視点から2010
    • Author(s)
      中村正帆、吉川雄朗、谷内一彦
    • Journal Title

      特集「脳とアレルギー」アレルギー・免疫

      Volume: 17(10) Pages: 1868-1868

    • Data Source
      KAKENHI-PROJECT-21390171

  • [Journal Article] Amyloid PET in mild cognitive impairment and Alzheimer's disease with BF-227 : Comparison to FDG-PET2010
    • Author(s)
      K. Furukawa, N. Okamura, M. Tashiro, M. Waragai, S. Furumoto, R. Iwata, K. Yanai; Y. Kudo, H. Arai
    • Journal Title

      J.Neurosurgery (印刷中)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390311

  • [Journal Article] Amyloid PET in mild cognitive impairment and Alzheimer's disease with BF-227 : comparis on to FDG-PET2010
    • Author(s)
      Furukawa K, Okamura N, Tashiro M, Waragai M, Furumoto S, Iwata R, Yanai K, Kudo Y, Arai H
    • Journal Title

      J Neurol

      Volume: 257 Pages: 721-727

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590754

  • [Journal Article] CONGAコンセンサスに準じたレボセチリジンの評価2010
    • Author(s)
      谷内一彦
    • Journal Title

      特集「新規抗ヒスタミン薬レボセチリジン」医薬ジャーナル

      Volume: 46(10) Pages: 2506-2511

    • Data Source
      KAKENHI-PROJECT-21390171

  • [Journal Article] In vivo visualization of {alpha}-synuclein deposition by carbon-11-labelled 2-[2-(2-dimethylaminothiazol-5-yl)ethenyl]-6-[2-(fluoro) ethoxy] benzoxazole positron emission tomography in multiple system atrophy.2010
    • Author(s)
      Kikuchi A, Takeda A, Yanai K, Itoyama Y, et al.
    • Journal Title

      Brain

      Volume: 133 Pages: 1772-1778

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21650088

  • [Journal Article] Amyloid PET in mild cognitive impairment and Alzheimer's disease with BF-227 : Comparison to FDG-PET2010
    • Author(s)
      K.i Furukawa, N.Okamura, M.Tashiro, M.Waragai, S.Furumoto, R.Iwata, K.Yanai, Y.Kudo, H.Arai
    • Journal Title

      J.Neurosurgery (In press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390311

  • [Journal Article] Multiple histamine receptor gene knockout mice and their phenotypes2009
    • Author(s)
      Sakurai E, Kuramasu A, Watanabe T, Yanai K.
    • Journal Title

      Inflamm Res

      Volume: 58 Pages: 41-2

    • Data Source
      KAKENHI-PROJECT-21590268

  • [Journal Article] Dose dependency of brain histamine H(1) receptor occupancy following oral administration of cetirizine hydrochloride measured using PET with [^<11>C]doxepin.2009
    • Author(s)
      Tashiro M, Yanai K, et al.
    • Journal Title

      Hum Psychopharmacol. 24(7)

      Pages: 540-548

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21650088

  • [Journal Article] ncreased Brain Histamine H1 Receptor Binding in Patients with Anorexia Nervosa2009
    • Author(s)
      Yoshizawa M, Tashiro M, Fukudo S, Yanai K, Utsumi A, Kano M, Karahasi M, Endo Y, Morisita J, Sato Y, Adachi M, Itoh M, Hongo M
    • Journal Title

      Biol Psychiatry

      Volume: 65(4) Pages: 329-35

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390171

  • [Journal Article] 抗ヒスタミン薬による運転能力障害に対する認識鼻アレルギーフロンティア2009
    • Author(s)
      谷内一彦、田代学、千葉真
    • Volume
      9(1)
    • Pages
      58-64
    • Data Source
      KAKENHI-PROJECT-21390171

  • [Journal Article] Increased Brain Histamine H1 Receptor Binding in Patients with Anorexia Nervosa2009
    • Author(s)
      Yoshizawa M, Yanai K, et.al.
    • Journal Title

      Biol Psychiatry 65(4)

      Pages: 329-335

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390061

  • [Journal Article] Dose dependency of brain histamine H(1)receptor occupancy following oral administration of cetirizine hydrochloride measured using PET with [11C] doxepin2009
    • Author(s)
      Tashiro M, Kato M, Miyake M, Watanuki S, Funaki Y, Ishikawa Y, Iwata R, Yanai K
    • Journal Title

      Hum Psychopharmacol

      Volume: 24(7) Pages: 540-8

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390171

  • [Journal Article] Histamine responses of large neostriatal interneurons in histamine H1 and H2 receptor knock-out mice2009
    • Author(s)
      Ogawa S, Yanai K, et.al.
    • Journal Title

      Brain Res Bull. 78(4-5)

      Pages: 189-194

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390061

  • [Journal Article] ヒスタミンH1、H2受容体遺伝子欠損マウスの作成と意義2009
    • Author(s)
      谷内一彦、赤池紀生
    • Journal Title

      生体の科学

      Volume: 60(5) Pages: 442-443

    • Data Source
      KAKENHI-PROJECT-21390171

  • [Journal Article] Increased Brain Histamine H1 Receptor Binding in Patients with Anorexia Nervosa2009
    • Author(s)
      Yoshizawa M, Tashiro M, Fukudo S, Yanai K, Utsumi A, Kano M, Karahasi M, Endo Y, Morisita J, Sato Y, Adachi M, Itoh M, Hongo M
    • Journal Title

      Biol Psychiatry 65(4)

      Pages: 329-335

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390061

  • [Journal Article] Histamine responses of large neostriatal interneurons in histamine H1 and H2 receptor knock-out mice2009
    • Author(s)
      Ogawa S, Yanai K, Watanabe T, Wang ZM, Akaike H, Ito Y, Akaike N
    • Journal Title

      Brain Res Bull

      Volume: 78(4-5) Pages: 189-94

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390171

  • [Journal Article] Methamphetamine- and 3,4-Methylenedioxymethamphetamine-Induced Behavioral Changes in Histamine H3-Receptor Knockout Mice.2009
    • Author(s)
      Okuda T, Yanai K, et al.
    • Journal Title

      J.Pharmacol.Sci. 111(2)

      Pages: 167-174

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390171

  • [Journal Article] Long-term performance evaluation of positron emission tomography-analysis and proposal of a maintenance protocol for long-term utilization.2009
    • Author(s)
      Watanuki S, Tashiro M, Miyake M, Ishikawa Y, Itoh M, Yanai K, Sakemi Y, Fukuda H, Ishii K.
    • Journal Title

      Ann Nucl Med. 21

      Pages: 148-156

    • NAID

      10026596410

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590754

  • [Journal Article] 抗ヒスタミン薬の鎮静作用評価に関するPET研究2009
    • Author(s)
      田代学, 谷内一彦.
    • Journal Title

      小児科 50

      Pages: 1463-1476

    • NAID

      40016787949

    • Data Source
      KAKENHI-PROJECT-21590754

  • [Journal Article]2009
    • Author(s)
      Yanai K., Okamura N, Iwata R, Tashiro M
    • Journal Title

      Molecular imaging and its application to drug development at Tohoku University. In : Nano-Biomedical Engineering 2009.(Ed. YAMAGUCHI Takami)(Imperial College Press)

      Pages: 175-183

    • Data Source
      KAKENHI-PROJECT-21590754

  • [Journal Article] 中枢に移行しない第二世代抗ヒスタミン薬:PETによる脳内移行性に関する研究.2009
    • Author(s)
      谷内一彦, 田代学, 岡村信行.
    • Journal Title

      西日本皮膚科 71

      Pages: 3-6

    • Data Source
      KAKENHI-PROJECT-21590754

  • [Journal Article] Methamphetamine- and 3,4-Methylenedioxymethamphetamine-Induced Behavioral Changes in Histamine H3-Receptor Knockout Mice.2009
    • Author(s)
      Okuda T, Yanai K, et al.
    • Journal Title

      J.Pharmacol.Sci. 111(2)

      Pages: 167-174

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21650088

  • [Journal Article] Roles of the histaminergic neurotransmission on methamphetamine-induced locomotor sensitization and reward : a study of receptors gene knockout mice2009
    • Author(s)
      Takino N, Sakurai E, Kuramasu A, Okamura N, Yanai K
    • Journal Title

      Int Rev Neurobiol

      Volume: 85 Pages: 109-16

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390171

  • [Journal Article] 抗ヒスタミン薬と認知機能:dimebonはアルツハイマー病の認知機能を改善する最近の話題2009
    • Author(s)
      谷内一彦、吉川雄朗
    • Journal Title

      日薬理誌

      Volume: 134 Pages: 235-235

    • Data Source
      KAKENHI-PROJECT-21390171

  • [Journal Article] Decreased CSF histamine in narcolepsy with and without low CSF hypocretin-1 in comparison to healthy controls2009
    • Author(s)
      Nishino S, Sakurai E, Nevsimalova S, Yoshida Y, Watanabe T, Yanai K, Mignot E
    • Journal Title

      Sleep 32(2)

      Pages: 175-180

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390061

  • [Journal Article] Enhanced morphine-induced antinociception in histamine H3 receptorgene knockout mice.2009
    • Author(s)
      Mobarakeh JI, Takahashi K, Yanai K.
    • Journal Title

      Neuropharmacology 57(4)

      Pages: 409-414

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390171

  • [Journal Article] Increased brain histamine H1receptor binding in patients with anorexia nervosa.2009
    • Author(s)
      Yoshizawa M, Tashiro M, Fukudo S, Yanai K, Utsumi A, Kano M, Karahasi M, Endo Y, Morisita J, Sato Y, Adachi M, Itoh M, Hongo M
    • Journal Title

      Biol Psychiatry. 65

      Pages: 329-335

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590754

  • [Journal Article] 抗ヒスタミン薬と運転能力低下.2009
    • Author(s)
      田代学, 谷内一彦
    • Journal Title

      日本医事新報 4446

      Pages: 42-45

    • Data Source
      KAKENHI-PROJECT-21590754

  • [Journal Article] Impact of serotonin transporter gene polymorphism on brain activation by colorectal distention.2009
    • Author(s)
      Fukudo S, Kanazawa M, Mizuno T, Hamaguchi T, Kano M, Watanabe S, Sagami Y, Shoji T, Endo Y, Hongo M, Itoyama Y, Yanai K, Tashiro M, Aoki M.
    • Journal Title

      Neuroimage 47

      Pages: 946-951

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590754

  • [Journal Article] Quantitative analysis of donepezil binding to acetylcholinesterase using positron emission tomography and [5-(11)C-methoxy]donepezil.2009
    • Author(s)
      Hiraoka K, Okamura N, Funaki Y, Watanuki S, Tashiro M, Kato M, Hayashi A, Hosokai Y, Yamasaki H, Fujii T, Mori E, Yanai K, Watabe H.
    • Journal Title

      Neuroimage 46

      Pages: 616-623

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590754

  • [Journal Article] Dose dependency of brain histamine H_1 receptor occupancy following oral administration of cetirizine hydrochloride measured using PET with [^<11>C] doxepin2009
    • Author(s)
      M.Tashiro, M.Kato, M.Miyake, S.Watanuki, Y.Funaki, Y.Ishikawa, R.Iwata, K.Yanai
    • Journal Title

      Human Psychopharmacol. 24

      Pages: 540-548

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390311

  • [Journal Article] Roles of the histaminergic neurotransmission on methamphetamine-induced locomotor sensitization and reward : a study of receptors gene knockout mice2009
    • Author(s)
      Takino N, Sakurai E, Kuramasu A, Okamura N, Yanai K.
    • Journal Title

      Int Rev Neurobiol

      Volume: 85 Pages: 109-16

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590268

  • [Journal Article] Impact of serotonin transporter gene polymorphism on brain activation by colorectal distention2009
    • Author(s)
      Fukudo S, Kanazawa M, Mizuno T, Hamaguchi T, Kano M, Watanabe S, Sagami Y, Shoji T, Endo Y, Hongo M, Itoyama Y, Yanai K, Tashiro M, Aoki M
    • Journal Title

      Neuroimage

      Volume: Vol.47 Pages: 946-951

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590754

  • [Journal Article] 中枢に移行しない第二世代抗ヒスタミン薬 : PETによる脳内移行性に関する研究2009
    • Author(s)
      谷内一彦, 田代学, 岡村信行
    • Journal Title

      西日本皮膚科 1巻1号

      Pages: 3-6

    • Data Source
      KAKENHI-PROJECT-19390061

  • [Journal Article] Comparison study of amyloid PET and voxel-based morphometry analysis in mild cognitive impairment and Alzheimer's disease.2009
    • Author(s)
      Waragai M, Okamura N, Furukawa K, Tashiro M, Furumoto S, Funaki Y, Kato M, Iwata R, Yanai K, Kudo Y, Arai H.
    • Journal Title

      J Neurol Sci. 285

      Pages: 100-108

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590754

  • [Journal Article] Methamphetamine-and 3, 4-Methylenedioxymethamphetamine-Induced Behavioral Changes in Histamine H(3)-Receptor Knockout Mice2009
    • Author(s)
      Okuda T, Zhang D, Shao H, Okamura N, Takino N, Iwamura T, Sakurai E, Yoshikawa T, Yanai K
    • Journal Title

      J Pharmacol Sci

      Volume: 111(2) Pages: 167-74

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390171

  • [Journal Article] Histamine responses of large neostriatal interneurons in histamine H1 and H2 receptor knock-out mice2009
    • Author(s)
      Ogawa S, Yanai K, Watanabe T, Wang ZM, Akaike H, Ito Y, Akaike N
    • Journal Title

      Brain Res Bull 78(4-5)

      Pages: 189-194

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390061

  • [Journal Article] Enhanced morphine-induced antinociception in histamine H3 receptor gene knockout mice2009
    • Author(s)
      Mobarakeh JI, Takahashi K, Yanai K
    • Journal Title

      Neuropharmacology

      Volume: 57(4) Pages: 409-14

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390171

  • [Journal Article] 抗ヒスタミン薬の新分類2009
    • Author(s)
      熊谷雄治、Ian Hindmarch、谷内一彦
    • Journal Title

      Not Impairing antihistamine (NIaH)とImpairing antihistamine (IaH)診断と治療

      Volume: 97(1) Pages: 77-186

    • Data Source
      KAKENHI-PROJECT-21390171

  • [Journal Article] Decreased CSF histamine in narcolepsy with and without low CSF hypocretin-1 in comparison to healthy controls2009
    • Author(s)
      Nishino S, Yanai K, et.al.
    • Journal Title

      Sleep 32(2)

      Pages: 175-180

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390061

  • [Journal Article] Dose dependency of brain histamine H1 receptor occupancy following oral administration of cetirizine hydrochloride measured using PET with [11C]doxepin.2009
    • Author(s)
      Tashiro M, Kato M, Miyake M, Watanuki S, Funaki Y, Ishikawa Y, Iwata R, Yanai K.
    • Journal Title

      Human Psychopharmacology 24

      Pages: 540-548

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590754

  • [Journal Article] Comparison study of amyloid PET and voxel-based morphometry analysis in mild cognitive impairment and Alzheimer's disease2009
    • Author(s)
      M. Waragai, N. Okamura, K. Furukawa, M. Tashiro, S. Furumoto, Y. Funaki, M. Kato, R. Iwata, K. Yanai, Y. Kudo, H. Arai
    • Journal Title

      J.Nuerol.Sci. 285巻

      Pages: 100-108

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390311

  • [Journal Article] Dose dependency of brain histamine H(1)receptor occupancy following oral administration of cetirizine hydrochloride measured using PET with[11C] doxepin2009
    • Author(s)
      Tashiro M, Kato M, Miyake M, Watanuki S, Funaki Y, Ishikawa Y, Iwata R, Yanai K
    • Journal Title

      Hum Psychopharmacol

      Volume: Vol.24 Pages: 540-548

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590754

  • [Journal Article] インペアード・パフォーマンス:国際標準に基づく抗ヒスタミン薬の使用法2009
    • Author(s)
      谷内一彦, 田代学
    • Journal Title

      医薬ジャーナル 45

      Pages: 687-693

    • Data Source
      KAKENHI-PROJECT-21590754

  • [Journal Article]2009
    • Author(s)
      Tashiro M, Yanai K.
    • Journal Title

      Potentials of nano-bio-imaging with positron emission tomography and radiopharmaceuticals. In : Nano-Biomedical Engineering 2009. IN : (Ed. YAMAGUCHI Takami)(Imperial College Press)

      Pages: 147-159

    • Data Source
      KAKENHI-PROJECT-21590754

  • [Journal Article] Dose dependency of brain histamine H_1 receptor occupancy following oral administration of cetirizine hydrochloride measured using PET with [^<11>C]doxepin2009
    • Author(s)
      M. Tashiro, M. Kato, M. Miyake, S. Watanuki, Y. Funaki, Y. Ishikawa, R. Iwata, K. Yanai
    • Journal Title

      Human Psychopharmacol 24巻

      Pages: 540-548

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390311

  • [Journal Article] Comparison study of amyloid PET and voxel-based morphometry analysis in mild cognitive impairment and Alzheimer's disease2009
    • Author(s)
      M.Waragai, N.Okamura, K.Furukawa, M.Tashiro, S.Furumoto, Y.Funaki, M.Kato, R.Iwata, K.Yanai, Y.Kudo, H.Arai
    • Journal Title

      J.Nuerol.Sci. 285

      Pages: 100-108

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390311

  • [Journal Article] インペアード・パフォーマンス : 国際標準に基づく抗ヒスタミン薬の使用法2009
    • Author(s)
      谷内一彦, 田代学
    • Journal Title

      医薬ジャーナル 45

      Pages: 687-693

    • Data Source
      KAKENHI-PROJECT-19390061

  • [Journal Article] Decreased CSF histamine in narcolepsy with and without low CSF hypocretin-1 in comparison to healthy controls2009
    • Author(s)
      Nishino S, Sakurai E, Nevsimalova S, Yoshida Y, Watanabe T, Yanai K, Mignot E
    • Journal Title

      Sleep

      Volume: 32(2) Pages: 175-80

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390171

  • [Journal Article] Intrathecal high-dose histamine induces spinally-mediated nociceptive behavioral responses through a polyamine site of NMDA receptors2008
    • Author(s)
      Watanabe C, Orito T, Watanabe H, Mizoguchi H, Yonezawa A, Yanai K, Mobarakeh JI, 0nodera K, Sakurada T, Sakurada S.
    • Journal Title

      Eur J Pharmacol. 581(1-2)

      Pages: 54-63

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18659155

  • [Journal Article] Effects of a sedative antihistamine, D-chlorpheniramine, on regional cerebral perfusion and performance during simulated car driving2008
    • Author(s)
      Tashiro M, Sakurada Y, Mochizuki H, Horikawa E, Maruyama M, Okamura N, Watanuki S, Arai H, Itoh M, Yanai K
    • Journal Title

      Hum Psychopharmacol 23(2)

      Pages: 139-150

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390061

  • [Journal Article] The roles of histamine H (1)receptors on cognition.2008
    • Author(s)
      Yanai K, Dai H, Sakurai E, Watanabe T.
    • Journal Title

      Inflamm Res. Supple1

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18500286

  • [Journal Article] 抗ヒスタミン薬のヒスタミンH1拮抗作用とインペアード・パフォーマンス2008
    • Author(s)
      谷内一彦, 田代学
    • Journal Title

      臨床免疫・アレルギー科 50(1)

      Pages: 46-51

    • Data Source
      KAKENHI-PROJECT-19390061

  • [Journal Article] 序にかえて「脳の核医学分子イメージング」2008
    • Author(s)
      谷内一彦, 須原哲也
    • Journal Title

      臨床放射線 53(7)

      Pages: 845-848

    • Data Source
      KAKENHI-PROJECT-19390061

  • [Journal Article] In vivo visualization of donepezil binding in the brain of patients with Alzheimer's disease2008
    • Author(s)
      N. Okamura, Y. Funaki, M. Tashiro, M. Kato, Y. Ishikawa, M. Maruyama, H. Ishikawa, K. Meguro, R. Iwata, K. Yanai
    • Journal Title

      Brit.J.Clin.Pharmacol. 65巻

      Pages: 472-479

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390311

  • [Journal Article] Brain histamine H1 receptor occupancy of orally administered antihistamines, bepotastine and diphenhydramine, measured by PET with 11C-doxepin2008
    • Author(s)
      Tashiro M, Duan X, Kato M, Miyake M, Watanuki S, Ishikawa Y, Funaki Y, Iwata R, Itoh M, Yanai K
    • Journal Title

      Br J Clin Pharmacol 65(6)

      Pages: 811-21

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390061

  • [Journal Article] The roles of histamine H(1)receptors on cognition.2008
    • Author(s)
      Yanai K, Dai H, Sakurai E, Watanabe T.
    • Journal Title

      Inflamm Res. Mar14;Epub(In press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390061

  • [Journal Article] Brain histamine H_1 receptor occupancy of orally administrated antihistamines, bepotastine and diphendydramine, measured by PET with ^<11>C-doxepin2008
    • Author(s)
      M. Tashiro, X. Duan, M. Kato, M. Miyake, S. Watanuki, Y. Ishikawa, Y. Funaki, R. Iwata, M. Itoh, K. Yanai
    • Journal Title

      Brit.J.Clin.Pharmacol. 65巻

      Pages: 811-821

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390311

  • [Journal Article] The roles of histamine H(1) receptors on cognition2008
    • Author(s)
      Yanai K, Dai H, Sakurai E Watanabe T.
    • Journal Title

      Inflamm Res 14

      Pages: 1-2

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18500286

  • [Journal Article] The roles of histamine H(1)receptors on cognition. Inflamm Res._2008
    • Author(s)
      Yanai K, Dai H, Sakurai E, Watanabe T.
    • Journal Title

      Inflamm Res. Supple1

      Pages: 182-182

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18500286

  • [Journal Article] Effects of a sedative antihistamine, D-chlorpheniramine, on regional cerebral perfusion and performance during simulated car driving. 2008 Mar,;2008
    • Author(s)
      Tashiro M, Sakurada Y, Mochizuki H, Horikawa E, Maruyama M, Okamura N, Watanuki S, Arai H, Itoh M, Yanai K.
    • Journal Title

      Hum Psychopharmacol. Hum Psychopharmacol. 23(2)

      Pages: 139-150

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390061

  • [Journal Article] Imaging amyloid pathology in the living brain2008
    • Author(s)
      Okamura N, Furumoto S, Arai H, Iwata R, Yanai K, Kudo Y
    • Journal Title

      Curr Med Imaging Rev 4

      Pages: 56-62

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390061

  • [Journal Article] Brain histamine H_1 receptor occupancy of orally administrated antihistamines, bepotastine and diphendydramine, measured by PET with ^<11>C-doxepin2008
    • Author(s)
      M. Tashiro, X. Duan, M. Kato, M. Miyake, S. Watanuki, Y. Ishikawa, Y. Funaki, R. Iwata, M. Itoh, K. Yanai
    • Journal Title

      Brit. J. Clin. Pharmacol. 65

      Pages: 811-821

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390311

  • [Journal Article] CLIC4 interacts with histamine H3 receptor and enhances the receptor cell surface expression2008
    • Author(s)
      Maeda K, Haraguchi M, Kuramasu A, Sato T, Ariake K, Sakagami H, Kondo H, Yanai K, Fukunaga K, Yanagisawa T, Sukegawa J
    • Journal Title

      Biochem Biophys Res Commun 369(2)

      Pages: 603-608

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390061

  • [Journal Article] CLIC4 interacts with histamine H3 receptor and enhances the receptor cell surface expression.2008
    • Author(s)
      Maeda K, Haraguchi M, Kuramasu A, Sato T, Ariake K, Sakagami H, Kondo H, Yanai K, Fukunaga K, Yanagisawa T, Sukegawa J.
    • Journal Title

      Biochem Biophys Res Commun. 369(2)

      Pages: 603-608

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390061

  • [Journal Article] アレルギー性皮膚疾患におけるエビデンスに基づいた抗ヒスタミン薬の選択2008
    • Author(s)
      川島眞、江藤隆史、江畑俊哉、大谷道輝、片山一朗、幸野健, 瀧川雅浩, 田邉昇, 中川秀巳, 原田昭太郎, 古川福実 森川昭広 谷内一彦
    • Journal Title

      臨床皮膚科 62(1)

      Pages: 8-15

    • Data Source
      KAKENHI-PROJECT-19390061

  • [Journal Article] Intrathecal high-dose histamine induces spinally-mediated nociceptive behavioral responses through a polyamine site of NMDA receptors2008
    • Author(s)
      Watanabe C, Orito T, Watanabe H, Mizoguchi H, Yonezawa A, Yanai K, Mobarakeh JI, Onodera K, Sakurada T, Sakurada S
    • Journal Title

      Eur J Pharmacol 581(1-2)

      Pages: 54-63

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390061

  • [Journal Article] In vivo visualization of donepezil binding in the brain of patients with Alzheimer's disease2008
    • Author(s)
      Okamura N, Funaki Y, Tashiro M, Kato M, Ishikawa Y, Maruyama M, Ishikawa H, Meguro K, Iwata R, Yanai K
    • Journal Title

      Br J Clin Pharmacol 65

      Pages: 472-479

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390061

  • [Journal Article] Measurement of BrdU in mouse brain by in-air micro PIXE analysis2008
    • Author(s)
      Sakurai E, Yanai K, Ishii K, Oyama R, Sakamaki M, Yamazaki H, Matsuyama S, Kamiya T, Satoh T, Haga J, Oikawa M, Arakawa K
    • Journal Title

      JAEA-Review 2007-060

      Pages: 182-182

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18500286

  • [Journal Article] Agonist-induced internalization of histamine H2 receptor and activation of extracellular signal-regulated kinases are dynamin-dependent2008
    • Author(s)
      Xu AJ, Kuramasu A, Maeda K, Kinoshita K, Takayanagi S, Fukushima Y, Watanabe T, Yanagisawa T, Sukegawa J, Yanai K
    • Journal Title

      J Neurochem 107

      Pages: 208-217

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390061

  • [Journal Article] Blocking histamine H1 improves learning and mnemonic dysfunction in mice with social isolation plus repeated methamphetamine injection2008
    • Author(s)
      Jia F, Mobarakeh JI, Dai H, Kato M, Xu A, Okuda T, Sakurai E, Okamura N, Takahashi K, Yanai K
    • Journal Title

      J Pharmacol Sci 107(2)

      Pages: 167-174

    • NAID

      130000075818

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390061

  • [Journal Article] Measurement of BrdU in mouse brain by in-air micro PIXE analysis2008
    • Author(s)
      Sakurai E. Yanai k, Ishii K, Oyama R, Sakamaki M, Yamazaki H, Matsuyama S, Kamiya T, Satoh T, Haga J, Oikawa M, Arakawa K.
    • Journal Title

      JAEA-Review 182

      Pages: 2007-6

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18500286

  • [Journal Article] Measurement of BrdU in mouse brain by in-air micro PIXE analysis2008
    • Author(s)
      Sakurai E, Yanai k, Ishii K, Oyama R, Sakamaki M, Yamazaki H, Matsuyama S, Kamiya T, Satoh T, Haga J, Oikawa M, Arakawa K
    • Journal Title

      JAEA Review 2007-06

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18500286

  • [Journal Article] 2-(2-[2-Dimethylaminothiazol-5-yl] ethenyl)-6-(2-[fluoro]ethoxy) benzoxazole : A novel PET agent for in vivo detection of dense amyloid plaques in Alzheimer's disease patients.2007
    • Author(s)
      Kudo Y, Yanai K, et al.
    • Journal Title

      J. Nucl. Med. 48(4)

      Pages: 553-561

    • Data Source
      KAKENHI-PROJECT-17390156

  • [Journal Article] The physiological and pathophysiological roles of neuronal histamine : an insight from human positron emission tomography studies.2007
    • Author(s)
      Yanai K et al.
    • Journal Title

      Pharmacol Ther 113

      Pages: 1-15

    • Data Source
      KAKENHI-PROJECT-18019004

  • [Journal Article] In Vivo Evaluation of P-Glycoprotein Modulation of 8 PET Radioligands Used Clinically.2007
    • Author(s)
      Ishiwata K, Yanai K, et al.
    • Journal Title

      J. Nucl. Med. 48

      Pages: 81-87

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17390156

  • [Journal Article] Selective cognitive dysfunction in mice lacking histamine H1 and H2 receptors.2007
    • Author(s)
      Dai H, Kaneko K, Kato H, Fujii S, Jing Y, Sakurai E, Kato M, Okamura N, Kuramasu A, Yanai K.
    • Journal Title

      Neuroscience Research 57(2)

      Pages: 306-313

    • NAID

      10021189206

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390156

  • [Journal Article] First achievement of less than 1 mm FWHM resolution in practical semiconductor animal PET scanner2007
    • Author(s)
      K. Ishii, Y. Kikuchi, S. Matsuyama, Y. Kanai, K. Kotani, T. Ito, H. Yamazaki, Y. Funaki, R. Iwata, M. Itoh, K. Yanai, J. Hatazawa, N. Itoh, N. Tanizaki, D. Amano, M. Yamada, T. Yamaguchi.
    • Journal Title

      Nucl. Instr. Meth. Phys. Res. A576

      Pages: 435-440

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390311

  • [Journal Article] Modified behavioral characteristics following ablation of the voltage-dependent calcium channel beta3 subunit2007
    • Author(s)
      Murakami M, Nakagawasai O, Yanai K, Nunoki K, Tan-No K, Tadano T, Iijima T
    • Journal Title

      Brain Res 1160

      Pages: 102-112

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390061

  • [Journal Article] Selective cognitive dysfunction in mice lacking histamine H1 and H2 receptors2007
    • Author(s)
      Dai H, Kaneko K, Kato H, Fujii S, Jing Y, Sakurai E, Kato M, Okamura N, Kuramasu A, Yanai K.
    • Journal Title

      Neuroscience Research 57(2)

      Pages: 306-313

    • NAID

      10021189206

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18500286

  • [Journal Article] The physiological and pathophysiological roles of neuronal histamine : An insight from human PET studies.2007
    • Author(s)
      Yanai K, Tashiro M.
    • Journal Title

      Pharmacology ＆ Therapeutics 113

      Pages: 1-15

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390156

  • [Journal Article] 2-(2-[2-Dimethylaminothiazol-5-yl]-ethyl)-6-(2-[fluoro]ethoxy]benzoxazole : a novel PET agent for in vivo detection of dense amyloid plaques in Alzhymer's disease patients2007
    • Author(s)
      Y. Kudo, N. Okamura, S. Furumoto, M. Tashiro, K. Furukawa, M. Maruyama, M. Itoh, R. Iwata, K. Yanai, H. Arai
    • Journal Title

      J.Nucl.Med. 48巻

      Pages: 553-561

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390311

  • [Journal Article] Selective cognitive dysfunction in mice lacking histamine H1 and H2 receptors.2007
    • Author(s)
      Dai H, Yanai K, et al.
    • Journal Title

      Neuroscience Research 57(2)

      Pages: 306-313

    • NAID

      10021189206

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17390156

  • [Journal Article] Recent advances in the development of amyloid imaging agents2007
    • Author(s)
      S. Furumoto, N. Okamura, R. Iwata, K. Yanai, Hi. Arai, Y. Kudo
    • Journal Title

      Current Topics in Medicinal Chemistry 7巻

      Pages: 1773-1789

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390311

  • [Journal Article] 抗アレルギー薬、抗精神病薬、抗うつ薬のヒスタミンH1拮抗作用と認知機能2007
    • Author(s)
      谷内一彦、加藤元久
    • Journal Title

      脳21 解説「脳とくすり」 10(1)

      Pages: 85-90

    • Data Source
      KAKENHI-PROJECT-19390061

  • [Journal Article] 脳内に移行する抗ヒスタミン薬の小児に与える影響2007
    • Author(s)
      谷内一彦、岡村信行、田代学
    • Journal Title

      小児科 48(10)

      Pages: 1435-1443

    • NAID

      40015635049

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390061

  • [Journal Article] The physiological and pathophysiological roles of neuronal histamine : An insight from human PET studies.2007
    • Author(s)
      Yanai K, Tashiro M.
    • Journal Title

      Pharmacology ＆ Therapeutics (2007) 113

      Pages: 1-15

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17390156

  • [Journal Article] Selective cognitive dysfunction in mice lacking histamine H1 and H2 receptors2007
    • Author(s)
      Dai H, Kaneko K, Kato H, Fujii S, Jing Y, Sakurai E. Kato M, Okamura N, Kuramasu A, Yanai K.
    • Journal Title

      Neuroscience Research 57 (2)

      Pages: 306-13

    • NAID

      10021189206

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18500286

  • [Journal Article] Correlation between alexithymia and hypersensitivity to visceral stimulation in human.2007
    • Author(s)
      Kano M, Yanai K, et al.
    • Journal Title

      Pain (In press)

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17390156

  • [Journal Article] First achievement of less than 1 mm FWHM resolution in practical semiconductor animal PET scanner.2007
    • Author(s)
      K.Ishii, K.Yanai, et al.
    • Journal Title

      Nuclear Instruments and Methods in Physics Research A (In press)

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17390156

  • [Journal Article] The physiological and pathophysiological roles of neuronal histamine: An insight from human PET studies2007
    • Author(s)
      Yanai K, Tashiro M
    • Journal Title

      Pharmacology & Therapeutics 113

      Pages: 1-15

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390061

  • [Journal Article] Neural correlates of perceptual difference between itching and pain: A human fMRI study2007
    • Author(s)
      Mochizuki H, Sadato H, Saito D. N., Toyoda H, Tashiro M, Okamura N, Yanai K
    • Journal Title

      Neuroimage 36

      Pages: 706-717

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390061

  • [Journal Article] 2-(2-[2-Dimethylaminothiazol-5-yl]ethyl)-6-(2-[fluoro]ethoxy]benzo xazole : a novel PET agent for in vivo detection of dense amyloid plaques in Alzhymer' s disease patients.2007
    • Author(s)
      Y.Kudo, N.Okamura, S.Furumoto, M.Tashiro, K.Furukawa, M.Maruyama, M.Itoh, R.Iwata, K.Yanai, H.Arai
    • Journal Title

      J. Nucl. Med. 48

      Pages: 553-561

    • Data Source
      KAKENHI-PROJECT-16390332

  • [Journal Article] 2-(2-[2-Dimethylaminothiazol-5-yl]ethenyl)-6-(2-[fluoro]ethoxy) benzoxazole : A novel PET agent for in vivo detection of dense amyloid plaques in Alzheimer′s disease patients.2007
    • Author(s)
      Kudo Y, Yanai K, et al.
    • Journal Title

      J. Nucl. Med. 48(4)

      Pages: 553-561

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17390156

  • [Journal Article] Brain activity associated with dual-task management differs depending on the combinations of response modalities2007
    • Author(s)
      Mochizuki H, Tashiro M, Gyoba J, Suzuki M, Okamura N, Itoh M, Yanai K
    • Journal Title

      Brain Res 1172C

      Pages: 82-92

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390061

  • [Journal Article] Evaluation of the binding characteristics of[18F]fluoroproxyfan in the rat brain for in vivo visualization of histamine H_3 receptor2007
    • Author(s)
      Y. Funaki, K. Sato, M. Kato, Y. Ishikawa, R. Iwata, and K. Yanai.
    • Journal Title

      Nucl. Med. Biol. 34

      Pages: 981-987

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390311

  • [Journal Article] Recent advances in the development of amyloid imaging agents2007
    • Author(s)
      Furumoto S, Okamura N, Iwata R, Yanai K, Arai H, Kudo Y
    • Journal Title

      Curr Top Med Chem 7(18)

      Pages: 1773-1789

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390061

  • [Journal Article] In Vivo Evaluation of P-Glycoprotein Modulation of 8 PET Radioligands Used Clinically.2007
    • Author(s)
      Ishiwata K, Kawamura K, Yanai K, Hendrikse H.N.
    • Journal Title

      J Nucl Med 48

      Pages: 81-87

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390156

  • [Journal Article] Evaluation of the binding characteristics of [(18)F] fluoroproxyfan in the rat brain for in vivo visualization of histamine H(3) receptor.2007
    • Author(s)
      Funaki Y, Sato K, Kato M, Ishikawa Y, Iwata R, Yanai K.
    • Journal Title

      Nucl Med Biol. 34(8)

      Pages: 981-987

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18659155

  • [Journal Article] The physiological and pathophysiological roles of neuronal histamine : an insight from human positron emission tomography studies.2007
    • Author(s)
      Yanai K
    • Journal Title

      Pharmacol Ther. 113(1)

      Pages: 1-15

    • Data Source
      KAKENHI-PROJECT-18500286

  • [Journal Article] First achievement of less than 1 mm FWHM resolution in practical semiconductor animal PET scanner2007
    • Author(s)
      K. Ishii, Y. Kikuchi, S. Matsuyama, Y. Kanai, K. Kotani, T. Ito, H. Yamazaki, Y. Funaki, R. Iwata, M. Itoh, K. Yanai, J. Hatazawa, N. Itoh, N. Tanizaki, D. Amano, M. Yamada, T. Yamaguchi
    • Journal Title

      Nucl.Instr.Meth.Phys.Res. A576巻

      Pages: 435-440

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390311

  • [Journal Article] Correlation between alexithymia and hypersensitivity to visceral stimulation in human2007
    • Author(s)
      Kano M, Hamaguchi T, Itoh M, Yanai K, Fukudo S
    • Journal Title

      Pain 132(3)

      Pages: 252-263

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390061

  • [Journal Article] Evaluation of the binding characteristics of [(18)F]fluoroproxyfan in the rat brain for in vivo visualization of histamine H(3) receptor2007
    • Author(s)
      Funaki Y, Sato K, Kato M, Ishikawa Y, Iwata R, Yanai K
    • Journal Title

      Nucl Med Biol 34(8)

      Pages: 981-987

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390061

  • [Journal Article] Neural correlates of perceptual difference between itching and pain : A human fMRI study.2007
    • Author(s)
      Mochizuki H, Yanai K, et al.
    • Journal Title

      Neuroimage (In press)

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17390156

  • [Journal Article] Selective cognitive dysfunction in mice lacking histamine H1 and H2 receptors.2007
    • Author(s)
      Dai H, Kaneko K, Kato H, Fujii S, Jing Y, Sakurai E, Kato M, Okamura N, Kuramasu A, Yanai K.
    • Journal Title

      Neuroscience Research 57(2)

      Pages: 306-313

    • NAID

      10021189206

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18659155

  • [Journal Article] First achievement of less than 1mm FWHM resolution in practical semiconductor animal PET scanner2007
    • Author(s)
      K. Ishii, Y. Kikuchi, S. Matsuyama, Y. Kanai, K. Kotani, T. Ito, H. Yamazaki, Y. Funaki, R. Iwata, M. Itoh, K. Yanai, J. Hatazawa, N. Itoh, et al., (他17名)
    • Journal Title

      Nuclear Instruments and Methods in Physics Research A576

      Pages: 435-440

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17002010

  • [Journal Article] 5-yl]ethenyl)-6-(2-[fluoro]ethoxy)benz oxazole : A novel PET agent for in vivo detection of dense amyloid plaques in Alzheimer's disease patients.2007
    • Author(s)
      Kudo Y, Okamura N, Furumoto S, Tashiro M, Furukawa K, Maruyama M, Itoh M, Iwata R, Yanai K, Arai H. 2-(2-[2-Dimethylaminothiazol-
    • Journal Title

      J.Nucl.Med. 48(4)

      Pages: 553-561

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390156

  • [Journal Article] 2-(2-[2-Dimethylaminothiazol-5-yl]ethyl)-6-(2-[fluoro]ethoxy]benzoxazole : a novel PET agent for in vivo detection of dense amyloid plaques in Alzhymer's disease patients.2007
    • Author(s)
      Y.Kudo, N.Okamura, S.Furumoto, M.Tashiro, K.Furukawa, M.Maruyama, M.Itoh, R.Iwata, K.Yanai, H.Arai
    • Journal Title

      J.Nucl.Med. 48

      Pages: 553-561

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16390332

  • [Journal Article] The physiological and pathophysiological roles of neuronal histamine : An insight from human PET studies2007
    • Author(s)
      K.Yanai
    • Journal Title

      Pharmacology ＆ Therapeutics 113(1)

      Pages: 1-15

    • Data Source
      KAKENHI-PROJECT-17002010

  • [Journal Article] PETによる分子・機能イメージングを組み合わせた脳機能研究2007
    • Author(s)
      鈴木美穂, 岡村信行, 谷内一彦
    • Journal Title

      認知神経科学 9(1)

      Pages: 62-65

    • Data Source
      KAKENHI-PROJECT-19390061

  • [Journal Article] Neural correlates of perceptual difference between itching and pain : A human fMRI study.2007
    • Author(s)
      Mochizuki H, Sadato H, Saito D.N., Toyoda H, Tashiro M, Okamura N, Yanai K.
    • Journal Title

      Neuroimage (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390156

  • [Journal Article] Evaluation of the binding characteristics of [^<18>F]fluoro-proxyfan in the rat brain for in vivo visualization of histamine H_3 receptor2007
    • Author(s)
      Y. Funaki, K. Sato, M. Kato, Y. Ishikawa, R. Iwata, K. Yanai
    • Journal Title

      Nucl.Med.Biol. 34巻

      Pages: 981-987

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390311

  • [Journal Article] First achievement of less than 1 mm FWHM resolution in practical semiconductor animal PET scanner.2007
    • Author(s)
      K.Ishii, Y.Kikuch, S.Matsuyama, Y.Kanai, K.Kotani, T.Ito, H.Yamazaki, Y.Funaki, R.Iwata, M.Itoh, K.Yanai, J.Hatazawa, N.Itoh, N.Tanizaki, D.Amano, M.Yamada, T.Yamaguchi.
    • Journal Title

      Nuclear Instruments and Methods in Physics Research A (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390156

  • [Journal Article] 2-(2-[2-Dimethylaminothiazol-5-yl] ethyl)-6-(2-[fluoro]ethoxy]benzoxazole : a novel PET agent for in vivo detection of dense amyloid plaques in Alzhymer's disease patients.2007
    • Author(s)
      Y.Kudo, N.Okamura, S.Furumoto, M.Tashiro, K.Furukawa, M.Maruyama, M.Itoh, R.Iwata, K.Yanai, H.Arai.
    • Journal Title

      J. Nucl. Med. 48

      Pages: 553-561

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16390332

  • [Journal Article] 2-(2-[2-Dimethylaminothiazol-5-yl]ethyl)-6-(2-[fluoro]ethoxy]benzoxazole: anovel PET agent for in vivo detection of dense amyloid plaques in Alzhymer's disease patients2007
    • Author(s)
      Y. Kudo, N. Okamura, S. Furumoto, M. Tashiro, K. Furukawa, M. Maruyama, M. Itoh, R. Iwata, K. Yanai and H. Arai.
    • Journal Title

      J. Nucl. Med. 48

      Pages: 553-561

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390311

  • [Journal Article] In Vivo Evaluation of P-Glycoprotein Modulation of 8 PET Radioligands Used Clinically2007
    • Author(s)
      Ishiwata K, Kawamura K, Yanai K, Hendrikse H.N
    • Journal Title

      J Nucl Med 48

      Pages: 81-87

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390061

  • [Journal Article] ヒスタミン受容体の分子イメージング2007
    • Author(s)
      田代学、谷内一彦
    • Journal Title

      BRAIN AND NERVE 59(3)

      Pages: 221-231

    • Data Source
      KAKENHI-PROJECT-19390061

  • [Journal Article] Selective cognitive dysfunction in mice lacking histamine H1 and H2 receptors.2007
    • Author(s)
      Dai H, Yanai K, et al.
    • Journal Title

      Neuroscience Research 57(2)

      Pages: 306-313

    • NAID

      10021189206

    • Data Source
      KAKENHI-PROJECT-18659155

  • [Journal Article] Correlation between alexithymia and hypersensitivity to visceral stimulation in human.2007
    • Author(s)
      Kano M, Hamaguchi T, Itoh M, Yanai K, Fukudo S.
    • Journal Title

      Pain (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390156

  • [Journal Article] Selective cognitive dysfunction in mice lacking histamine H1 and H2 receptors2007
    • Author(s)
      Dai H, Kaneko K, Kato H, Fujii S, Jing Y, Sakurai E, Kato M, Okamura N, Kuramasu A, Yanai K
    • Journal Title

      Neuroscience Research 57(2)

      Pages: 306-313

    • NAID

      10021189206

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390061

  • [Journal Article] Effects of histamine H3 antagonists and donepezil on learning and mnemonic deficits induced by pentylenetetrazol kindling in weanling mice.2006
    • Author(s)
      Jia FY, Yanai K, et al.
    • Journal Title

      Neuropharmacology 50(4)

      Pages: 404-411

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17390156

  • [Journal Article] Brain histamine H1 receptor occupancy of orally-administered antihistamines measured by positron emission tomography with ^<11>C-doxepin in a placebo-controlled crossover study-design in healthy volunteers : a comparison of olopatadine and ketotifen.2006
    • Author(s)
      Tashiro M, Yanai K, et al.
    • Journal Title

      Br. J. Clin. Pharmacol. 61(1)

      Pages: 16-26

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17390156

  • [Journal Article] Effects of histamine H3 antagonists and donepezil on learning and mnemonic deficits induced by pentylenetetrazol kindling in weanling mice.2006
    • Author(s)
      FY Jia, M.Kato, H.Dai, AJ Xu, T.Okuda, E.Sakurai, N.Okamura, T.W.Lovenberg, A.Barbier, N.I.Carruthers, K.Iinuma, K.Yanai.
    • Journal Title

      Neuropharmacology 50(4)

      Pages: 404-411

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390156

  • [Journal Article] Enhanced antinociceptive effects of morphine in histamine H2 receptor gene knockout mice.2006
    • Author(s)
      Mobarakeh J I, Yanai K, et al.
    • Journal Title

      Neuropharmacology 51(3)

      Pages: 612-622

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17390156

  • [Journal Article] Evidence for the presence of histamine uptake into the synaptosomes of rat brain.2006
    • Author(s)
      Sakurai E, Yanai K, et al.
    • Journal Title

      Pharmacology 78(2)

      Pages: 72-80

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17390156

  • [Journal Article] Effects of Histamine H3 antagonists and Donepezil on Learning and Mnemonic Deficits Induced by Pentylenetetrazol Kindling in Weanling Mice2006
    • Author(s)
      Jia F, Kato M, Dai H, Xu A, Okuda T, Sakurai E. Okamura N, Lovenberg TW, Barbier A, Carruthers NI, Iinuma K, Yanai K.
    • Journal Title

      Neurophamacology 50 (4)

      Pages: 404-411

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18500286

  • [Journal Article] Brain histamine H1 receptor occupancy of orally-administered antihistamines measured by positron emission tomography with 11C-doxepin in a placebo-controlled crossover study-design in healthy volunteers : a comparison of olopatadine and ketotifen.2006
    • Author(s)
      Tashiro M, Mochizuki H, Sakurada Y, Ishii K, Oda K, Kimura Y, Sasaki T, Ishiwata K, Yanai K.
    • Journal Title

      Br.J.Clin.Pharmacol. 61(1)

      Pages: 16-26

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390156

  • [Journal Article] Effects of Histamine H3 antagonists and Donepezil on Learning and Mnemonic Deficits Induced by Pentylenetetrazol Kindling in Weanling Mice2006
    • Author(s)
      Jia F, Kato M, Dai H, Xu A, Okuda T, Sakurai E, Okamura N, Lovenberg TW, Barbier A, Carruthers NI, Iinuma K, Yanai K,
    • Journal Title

      Neurophamacology, 50(4)

      Pages: 404-411

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18500286

  • [Journal Article] Development of an In-Air ON/OFF Axis STIM System for Quantitative Elemental Mapping.2006
    • Author(s)
      K. Inomata, K. Ishii, H. Yamazaki, S. Matsuyama, Y. Kikuchi, Y. Watanabe, A. Ishizaki, R. Oyama, Y. Kawamura, T. Yamaguchi, G. Momose, E. Sakurai, K. Yanai, T. Kamiya, T. Sakai, T. Satoh, M. Oikawa, K. Arakawa,
    • Journal Title

      International Jounal of PIXE 16(3&4)

      Pages: 149-156

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18500286

  • [Journal Article] Brain histamine H_1 receptor occupancy of orally-administered antihistamines measured by positron emission tomography with ^<11>C-doxepin in a placebe-controlled crossover study-desing in healthy volunteers : a comparison of olopatadine and ketotifen.2006
    • Author(s)
      Tashiro M, Yanai K, et al.
    • Journal Title

      Br.J.Clin.Pharmacol. 61・1

      Pages: 16-26

    • Data Source
      KAKENHI-PROJECT-17390156

  • [Journal Article] Evidence for presence of histamine uptake into the synaptosomes of rat brain, 2006;:2006
    • Author(s)
      Sakurai E, Sakurai E, Oreland L, Nishiyama S, Kato M, Watanabe T, Yanai K.
    • Journal Title

      Pharmacol. 78(2)

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18500286

  • [Journal Article] Effects of histamine H3 antagonists and donepezil on learning and mnemonic deficits induced by pentylenetetrazol kindling in weanling mice.2006
    • Author(s)
      FY Jia, K.Yanai, et al.
    • Journal Title

      Neuropharmacology 50・4

      Pages: 404-411

    • Data Source
      KAKENHI-PROJECT-17390156

  • [Journal Article] Evidence for presence of histamine uptake into the synaptosomes of rat brain2006
    • Author(s)
      Sakurai E. Sakurai E, Oreland L, Nishiyama S, Kato M, Watanabe T, Yanai K.
    • Journal Title

      Pharmacol 78 (2)

      Pages: 72-80

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18500286

  • [Journal Article] Enhanced antinociceptive effects of morphine in histamine H2 receptor gene knockout mice.2006
    • Author(s)
      Mobarakeh JI, Yanai K. et al.
    • Journal Title

      Neuropharmacology 51(3)

      Pages: 612-622

    • Data Source
      KAKENHI-PROJECT-18659155

  • [Journal Article] Evidence for the presence of histamine uptake into the synaptosomes of rat brain.2006
    • Author(s)
      Sakurai E, Yanai K, et al.
    • Journal Title

      Pharmacology 78(2)

      Pages: 72-80

    • Data Source
      KAKENHI-PROJECT-18659155

  • [Journal Article] Effects of histamine H3 antagonists and donepezil on learning and mnemonic deficits induced by pentylenetetrazol kinding in weanling mice.2006
    • Author(s)
      FY Jia, K.Yanai, et al.
    • Journal Title

      Neuropharmacology 50(4)

      Pages: 404-411

    • Data Source
      KAKENHI-PROJECT-18659155

  • [Journal Article] Brain histamine H1 receptor occupancy of orally-administered antihistamines measured by positron emission tomography with ^<11>C-doxepin in a placebo-controlled crossover study-design in healthy volunteers : a comparison of olopatadine and ketotifen.2006
    • Author(s)
      Tashiro M, Yanai K, et al.
    • Journal Title

      Br.J.Clin.Pharmacol. 61・1

      Pages: 16-26

    • Data Source
      KAKENHI-PROJECT-17639014

  • [Journal Article] Enhanced antinociceptive effects of morphine in histamine H2 receptor gene knockout mice.2006
    • Author(s)
      Mobarakeh J I, Takahashi K, Sakurada S, Kuramasu A, Yanai K.
    • Journal Title

      Neuropharmacology 51(3)

      Pages: 612-622

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390156

  • [Journal Article] Development of an In-Air ON/OFF Axis STIM System for Quantitative Elemental Mapping2006
    • Author(s)
      K. Inomata, K. Ishii, H. Yamazaki, S. Matsuyama, Y. Kikuchi, Y. Watanabe, A. Ishizaki, R. Oyama, Y. Kawamura, T. Yamaguchi, G Momose, E. Sakurai. K. Yanai, T. Kamiya, T. Sakai, T. Satoh, M. Oikawa, K. Arakawa
    • Journal Title

      International Jounal of PIXE 16 (3 & 4)

      Pages: 149-156

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18500286

  • [Journal Article] Effects of histamine H3 antagonists and donepezil on learning and mnemonic deficits induced by pentylenetetrazol kindling in weanling mice.2006
    • Author(s)
      FY Jia, K.Yanai, et al.
    • Journal Title

      Neuropharmacology 50・4

      Pages: 404-411

    • Data Source
      KAKENHI-PROJECT-17639014

  • [Journal Article] Evidence for the presence of histamine uptake into the synaptosomes of rat brain.2006
    • Author(s)
      Sakurai E, Sakurai E, Oreland L, Nishiyama S, Kato M, Watanabe T, K. Yanai.
    • Journal Title

      Pharmacology 78(2)

      Pages: 72-80

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390156

  • [Journal Article] A PET study of histamine H1 receptors in the schizophrenic patients assessed by [^<11>C]doxepin.2005
    • Author(s)
      Iwabuchi K, Yanai K, et al.
    • Journal Title

      Eur Neuropsychopharmacol. 15(2)

      Pages: 185-191

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14370027

  • [Journal Article] Effects of activation of central nervous histamine receptors in cardiovascular regulation ; studies in H1 and H2 receptor gene knockout mice2005
    • Author(s)
      Suzuki H, J.I.Mobarakeh, Nunoki Sukegawa J, Watanabe H, Kuramasu A, Watanabe T, Yanai K, Yanagisawa T.
    • Journal Title

      Naunyn Schmiedebergs Arch Pharmacol. 371(2)

      Pages: 99-106

    • NAID

      120000787414

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370027

  • [Journal Article] Blockage of histamine H1 receptor attenuates social isolation-induced disruption of pre-pulse inhibition : A study in H1 receptor gene knockout mice.2005
    • Author(s)
      Dai H, Yanai K, et al.
    • Journal Title

      Psychopharmacology 183・3

      Pages: 285-293

    • Data Source
      KAKENHI-PROJECT-17390156

  • [Journal Article] Effects of fexofenadine and hydroxyzine on brake reaction time.2005
    • Author(s)
      Tashiro M, Yanai K, et al.
    • Journal Title

      Hum.Psychopharmacol. 20

      Pages: 501-509

    • Data Source
      KAKENHI-PROJECT-17639014

  • [Journal Article] A PET study of histamine H1 receptors in the schizophrenic patients assessed by [^<11>C]doxepin.2005
    • Author(s)
      Iwabuchi K, Ito C, Tashiro M, Mochizuki H, Kato M, Kano M, Ishii K, Ishiwata K, Itoh M, Iwata R, Matsuoka H, Sato M, Yanai K.
    • Journal Title

      Eur.Neuropsychopharmacol. 15(2)

      Pages: 185-191

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370027

  • [Journal Article] Effects of activation of central nervous histamine receptors in cardiovascular regulation ; studies in H1 and H2 receptor gene knockout mice.2005
    • Author(s)
      Suzuki H, Yanai K, et al.
    • Journal Title

      Naunyn Schmiedebergs Arch Pharmacol. 371(2)

      Pages: 99-106

    • NAID

      120000787414

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14370027

  • [Journal Article] Blockage of histamine H1 receptor attenuates social isolation-induced disruption of pre-pulse inhibition : A study in H1 receptor gene knockout mice.2005
    • Author(s)
      Dai H, Yanai K, et al.
    • Journal Title

      Psychopharmacology 183(3)

      Pages: 285-293

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17390156

  • [Journal Article] A PET study of histamine H1 receptors in schizophrenic patients assessed by [^<11>C] doxepin2005
    • Author(s)
      K.Iwabuchi, C.Ito, M.Tashiro, H.Mochizuki, M.Kato, M.Kano, K.Ishii, K.Ishiwata, M.Itoh, R.Iwata, H.Matsuoka, M.Sato, K.Yanai.
    • Journal Title

      Eur.Neuropsychopharmacol. 15

      Pages: 185-191

    • Data Source
      KAKENHI-PROJECT-16390332

  • [Journal Article] A PET study of histamine Hi receptors in the schizophrenic patients assessed by [^<11>C]doxepin.2005
    • Author(s)
      Iwabuchi K, Yanai K et al.
    • Journal Title

      Eur Neuropsychopharmacol. 15・2

      Pages: 185-191

    • Data Source
      KAKENHI-PROJECT-17639014

  • [Journal Article] Blockage of histamine H1 receptor attenuates social isolation-induced disruption of pre-pulse inhibition : A study in H1 receptor gene knockout mice.2005
    • Author(s)
      Dai H, Yanai K, et al.
    • Journal Title

      Psychopharmacology 183・3

      Pages: 285-293

    • Data Source
      KAKENHI-PROJECT-17639014

  • [Journal Article] Enhanced antinociception by intracerebroventricularly and intrathecally-administered orexin A and B in mice.2005
    • Author(s)
      J.I.Mobarakeh, K.Yanai, et al.
    • Journal Title

      Peptides 26(5)

      Pages: 767-777

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14370027

  • [Journal Article] Blockage of histamine H1 receptor attenuates social isolation-induced disruption of pre-pulse inhibition : A study in H1 receptor gene knockout mice.2005
    • Author(s)
      Dai H, Okuda T, Sakurai E, Kuramasu A, Kato M, Jia FY, Xu AJ, Iinuma K, Sato I, Yanai K.
    • Journal Title

      Psychopharmacology 183(3)

      Pages: 285-293

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390156

  • [Journal Article] Effects of fexofenadine and hydroxyzine on brake reaction time.2005
    • Author(s)
      Tashiro M, Yanai K, et al.
    • Journal Title

      Hum.Psychopharmacol. 20

      Pages: 501-509

    • Data Source
      KAKENHI-PROJECT-17390156

  • [Journal Article] Enhanced antinociception by intracerebroventricularly and intrathecally-administered orexin A and B in mice.2005
    • Author(s)
      J.I.Mobarakeh, K.Takahashi, S.Sakurada, S.Nishino, H.Watanabe, M.Kato, K.Yanai
    • Journal Title

      Peptides 26(5)

      Pages: 767-777

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370027

  • [Journal Article] Quinoline and benzimidazole derivatives candidate probes for in vivo imaging of tau pathology in Alzheimer's disease.2005
    • Author(s)
      Okamura N, Suemoto T, Furumoto S, Suzuki M; Shimadzu H, Akatsu H, Yamamoto T, Fujiwara H, Nemoto M, Maruyama M, Arai H, Yanai K, Sawada T, Kudo Y.
    • Journal Title

      J Neurosci. 25(47)

      Pages: 10857-10862

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390156

  • [Journal Article] Quinoline and benzimidazole derivatives : candidate probes for in vivo imaging of tau pathology in Alzheimer's disease.2005
    • Author(s)
      Okamura N, Yanai K, et al.
    • Journal Title

      J.Neurosci. 25・47

      Pages: 10857-10862

    • Data Source
      KAKENHI-PROJECT-17639014

  • [Journal Article] Quinoline and benzimidazole derivatives : candidate probes for in vivo imaging of tau pathology in Alzheimer's disease.2005
    • Author(s)
      Okamura N, Yanai K, et al.
    • Journal Title

      J.Neurosci. 25・47

      Pages: 10857-10862

    • Data Source
      KAKENHI-PROJECT-17390156

  • [Journal Article] Quinoline and benzimidazole derivatives : candidate probes for in vivo imaging of tau pathology in Alzheimer's disease.2005
    • Author(s)
      Okamura N, Yanai K, et al.
    • Journal Title

      J Neurosci. 25(47)

      Pages: 10857-10862

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17390156

  • [Journal Article] A PET study of histamine H1 receptors in the schizophrenic patients assessed by [^<11>C]doxepin.2005
    • Author(s)
      Iwabuchi K, Yanai K. et al.
    • Journal Title

      Eur Neuropsychopharmacol. 15・2

      Pages: 185-191

    • Data Source
      KAKENHI-PROJECT-17390156

  • [Journal Article] Central effects of fexofenadine and cetirizine : measurement of psychomotor performance, subjective sleepiness, and brain histamine H_1-receptor occupancy using ^<11>C-doxepin positron emission tomography.2004
    • Author(s)
      M.Tashiro, Y.Sakurada, K.Iwabuchi, H.Mochizuki, M.Kato, M.Aoki, Y.Funaki, M.Itoh, R.Iwata, D.F.Wong, K.Yanai
    • Journal Title

      J.Clinic.Pharmacol. 44

      Pages: 890-900

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16390332

  • [Journal Article] Simplified PET measurement for evaluating histamine H1 receptors in human brains using [^<11>C]doxepin.2004
    • Author(s)
      Mochizuki H, Kimura Y, Ishii K, Oda K, Sasaki T, Tashiro M, Yanai K, Ishiwata K.
    • Journal Title

      Nucl.Med.Biol. 31(8)

      Pages: 1005-1011

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370027

  • [Journal Article] Drug interaction between methamphetamine and antihistamines : behavioral changes and tissue concentration of methamphetamine in rats.2004
    • Author(s)
      Okuda T, Ito Y, Nakagawa N, Hishinuma T, Tsukamoto H, Iwabuchi K, Watanabe T, Kitaichi K, Goto J, Yanai K.
    • Journal Title

      Eur.J.Pharmacol. 505

      Pages: 135-144

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370027

  • [Journal Article] Evaluation of in vivo selective binding of [^<11>C]doxepin to histamine Hi receptors in five animal species.2004
    • Author(s)
      K.Ishiwata, K.Kawamura, W.-F.Wang, H.Tsukada, N.Harada, H.Mochizuki, Y.Kimura, K.Ishii, R.Iwata, K.Yanai
    • Journal Title

      Nucl.Med.Biol. 31

      Pages: 493-502

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16390332

  • [Journal Article] The anorectic effect of neurotensin is mediated via a histamine H1 receptor in mice.2004
    • Author(s)
      Ohinata K, Yanai K, et al.
    • Journal Title

      Peptides 12

      Pages: 2135-2138

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14370027

  • [Journal Article] Evaluation of in vivo selective binding of [^<11>C]doxepin to histamine H_1 receptors in five animal species2004
    • Author(s)
      K.Ishiwata, K.Kawamura, W.-F.Wang, H.tsukada, N.Harada, H.Mochizuki, Y.Kimura, K.Ishii, R.Iwata, K.Yanai
    • Journal Title

      Nucl.Med.Biol. 31

      Pages: 493-502

    • Data Source
      KAKENHI-PROJECT-16390332

  • [Journal Article] Central effects of fexofenadine and cetirizine : measurement of psychomotor performance, subjective sleepiness, and brain histamine H_1-receptor occupancy using ^<11>C-doxepin positron emission tomography2004
    • Author(s)
      M.Tashiro, Y.Sakurada, K.Iwabuchi, H.Mochizuki, M.Kato, M.Aoki, Y.Funaki, M.Itoh, R.Iwata, D.F.Wong, K.Yanai
    • Journal Title

      J.Clinic.Pharmacol 44

      Pages: 890-900

    • Data Source
      KAKENHI-PROJECT-16390332

  • [Journal Article] Evaluation of in vivo selective binding of [^<11>C]doxepin to histamine H_1 receptors in five animal species2004
    • Author(s)
      K.Ishiwata, K.Kawamura, W.-F.Wang, H.tsukada, N.Harada, H.Mochizuki, Y.Kimura, K.Ishii, R.Iwata, K.Yanai
    • Journal Title

      Nucl. Med. Biol. 31

      Pages: 493-502

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16390332

  • [Journal Article] The anorectic effect of neurotensin is mediated via a histamine H1 receptor in mice.2004
    • Author(s)
      Ohinata K, Shimano T, Yamauchi R, Sakurada S, Yanai K, Yoshikawa M.
    • Journal Title

      Peptides 12

      Pages: 2135-2138

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370027

  • [Journal Article] Central effeicts of fexofenadine and cetirizine : measurement of psychomotor performance, subjective sleepiness, and brain histamine H_1-receptor occupancy using ^<11>C-doxepin positron emission tomography2004
    • Author(s)
      M.Tashiro, Y.Sakurada, K.Iwabuchi, H.Mochizuki, M.Kato, M.Aoki, Y.Funaki, M.Itoh, R.Iwata, D.F.Wong, K.Yanai
    • Journal Title

      J. Clinic. Pharmacol 44

      Pages: 890-900

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16390332

  • [Journal Article] Simplified PET measurement for evaluating histamine H1 receptors in human brains using [^<11>C]doxepin.2004
    • Author(s)
      Mochizuki H, Yanai K, et al.
    • Journal Title

      Nucl.Med.Biol. 31(8)

      Pages: 1005-1011

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14370027

  • [Journal Article] Drug interaction between methamphetamine and antihistamines : behavioral changes and tissue concentration of methamphetamine in rats.2004
    • Author(s)
      Okuda T, Yanai K, et al.
    • Journal Title

      Eur.J.Pharmacol.(2004) 505

      Pages: 135-144

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14370027

  • [Journal Article] ^<18>F-THK523 : a novel in vivo tau imaging ligand for Alzheimer's disease.
    • Author(s)
      Fodero-Tavoletti MT, Yanai K, Villemagne VL, et al
    • Journal Title

      Brain

      Volume: 134 Pages: 1089-1100

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21650088

  • [Journal Article] The safety of newer antihistamines : Evaluation of their sedative properties by positron emission tomography
    • Author(s)
      Yanai K, Zhang D, Tashiro M, Shibuya K, Naganuma, Harada R, Nakamura T, Yoshikawa T, Okamura N
    • Journal Title

      Expert Opinion on Drug Safety

      Volume: 2011(未定)(印刷中)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590754

  • [Journal Article] Brain histamine H1 receptor occupancy of loratadine measured by PET : Comparison of H1 receptor occupancy and proportional impairment ratio
    • Author(s)
      Kubo N, Senda M, Osumi Y, Sakamoto S, Matsumoto K, Tashiro M, Okamura N, Yanai K
    • Journal Title

      Human Psychopharmacol

      Volume: 2011(未定)(印刷中)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590754

  • [Patent] ポジトロン放出核種標識タンパク質合成方法2017
    • Inventor(s)
      原田龍一、谷内一彦、岩田錬、古本祥三、谷内亜衣
    • Industrial Property Rights Holder
      原田龍一、谷内一彦、岩田錬、古本祥三、谷内亜衣
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2017-219798
    • Filing Date
      2017
    • Data Source
      KAKENHI-PROJECT-16K15314

  • [Patent] ポジトロン放出核種標識タンパク質合成方法2017
    • Inventor(s)
      原田龍一、谷内一彦、岩田錬、古本祥三、谷内亜衣
    • Industrial Property Rights Holder
      原田龍一、谷内一彦、岩田錬、古本祥三、谷内亜衣
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2017-219798
    • Filing Date
      2017
    • Data Source
      KAKENHI-PLANNED-26117003

  • [Patent] ポジトロン標識たんぱく質の合成方法2009
    • Inventor(s)
      谷内一彦、岩田錬、加藤元久、大貫哲也、古本祥三
    • Industrial Property Rights Holder
      谷内一彦、岩田錬、加藤元久、大貫哲也、古本祥三
    • Industrial Property Number
      2009-116379
    • Filing Date
      2009-05-25
    • Data Source
      KAKENHI-PROJECT-21650088

  • [Patent] アミロイドβ蛋白が蓄積する疾患の画像診断プローブ2006
    • Inventor(s)
      工藤幸司, 谷内一彦ほか
    • Industrial Property Rights Holder
      東北大学
    • Industrial Property Number
      2006-047064
    • Filing Date
      2006-02-23
    • Data Source
      KAKENHI-PROJECT-17639014

  • [Patent] アミロイドβ蛋白が蓄積する疾患の画像診断プローブ2006
    • Inventor(s)
      工藤幸司, 谷内一彦, ほか
    • Industrial Property Rights Holder
      東北大学
    • Industrial Property Number
      2006-047064
    • Filing Date
      2006-02-23
    • Data Source
      KAKENHI-PROJECT-17390156

  • [Presentation] Amyloid, tau and reactive astrocytosis imaging in aging and Alzheimer’s disease2021
    • Author(s)
      Victor L Villemagne Ryuichi Harada, Vincent Dore, Shozo Furumoto, Rachel Mulligan, Yukitsuka Kudo, Samantha Burnham, Natasha Krishnadas, Kun Huang, Kazuhiko Yanai, Christopher C Rowe, and Nobuyuki Okamura
    • Organizer
      ADPD2021
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19KK0212

  • [Presentation] 18F標識タンパク質による脳内分子イメージング手法の開発2021
    • Author(s)
      盛戸貴裕、原田 龍一、岩田 練、堵 怡青、岡村 信行、工藤 幸司、谷内 一彦
    • Organizer
      第94回日本薬理学会年会
    • Data Source
      KAKENHI-PROJECT-20K21564

  • [Presentation] Evaluation of the novel 18F-labeled PET tracer SMBT-1 for imaging astrogliosis in healthy elderly controls and in Alzheimer’s disease2020
    • Author(s)
      Victor L Villemagne Ryuichi Harada, Vincent Dore, Shozo Furumoto, Rachel Mulligan, Yukitsuka Kudo, Samantha Burnham, Natasha Krishnadas, Kun Huang, Kazuhiko Yanai, Christopher C Rowe, and Nobuyuki Okamura
    • Organizer
      AAIC2020
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19KK0212

  • [Presentation] 非天然アミノ酸の導入技術によるタンパク質RI標識法の開発2020
    • Author(s)
      盛戸貴裕、原田 龍一、岩田 練、谷内 一彦
    • Organizer
      第71回日本薬理学会北部会
    • Data Source
      KAKENHI-PROJECT-20K21564

  • [Presentation] Assessing Abe-a, tau, and reactive astrocytosis in aging and AD2020
    • Author(s)
      Victor L Villemagne, Ryuichi Harada, Kazuhiko Yanai, et al.
    • Organizer
      HUMAN AMYLOID IMAGING CONFERENCE 2020（マイアミ）
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19KK0212

  • [Presentation] Preclinical characterization of [18F]THK-5562, a novel tau PET tracer with little off-target binding2020
    • Author(s)
      Harada R, Lerdsirisuk P, Du Y, Ezura M, Shimizu Y, Morito T, Arai H, Yanai K,Kudo Y, Furumoto S, Okamura N
    • Organizer
      HUMAN AMYLOID IMAGING CONFERENCE 2020（マイアミ）
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19KK0212

  • [Presentation] Development and Identification of [18F]SNFT-1 (THK-5562), a Promising Candidate for Selective Tau PET Tracer in Alzheimer’s Disease2020
    • Author(s)
      Pradith Lerdsirisuk, Ryuichi Haradac, Yuki Shimizub, Yiqing Du, Yoichi Ishikawa, Ren Iwata, Kazuhiko Yanai, Yukitsuka Kudo, Nobuyuki Okamurab, Shozo Furumoto
    • Organizer
      EANM2020
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19KK0212

  • [Presentation] Discovery and evaluation of a novel tau PET tracer [F-18]THK-5562 for Alzheimer's disease2020
    • Author(s)
      Du Y, Harada R, Lerdsirisuk P, Ezura M, Shimizu Y, Morito T, Arai H, Kudo Y, Furumoto S, Yanai K
    • Organizer
      第93回日本薬理学会（横浜）
    • Data Source
      KAKENHI-PROJECT-19KK0212

  • [Presentation] 脳内PETイメージングに向けたBBB透過性ペプチド融合affibodyの薬物動態2019
    • Author(s)
      盛戸貴裕、原田龍一、堵 怡青、岩田錬、古本祥三、谷内一彦
    • Organizer
      第70回日本薬理学会北部会（札幌）
    • Data Source
      KAKENHI-PROJECT-19KK0212

  • [Presentation] Radiolabeled proteins for the development of biopharmaceuticals2019
    • Author(s)
      原田龍一、谷内一彦
    • Organizer
      第92回日本薬理学会年会
    • Data Source
      KAKENHI-PLANNED-26117003

  • [Presentation] Imaging-autopsy correlation of 18F-THK5351 in typical and atypical cases of progressive supranuclear palsy.2018
    • Author(s)
      Harada R, Ishiki A, Kai H, Furukawa K, Furumoto S, Tashiro M, Kitamoto T, Kudo Y, Yanai K, Arai H, Okamura N.
    • Organizer
      The 11th Human Amyloid Imaging (HAI) meeting
    • Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-26117003

  • [Presentation] Structure-binding relationship of quinoline derivatives on monoamine oxidase B.2018
    • Author(s)
      Okamura N, Harada R, Furumoto S, Arai H, Yanai K, Kudo Y.
    • Organizer
      The 11th Human Amyloid Imaging (HAI) meeting
    • Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-26117003

  • [Presentation] フェルラ酸誘導体による ミスフォールディング蛋白質の凝集抑制2018
    • Author(s)
      原田龍一、岡村信行、谷内一彦
    • Organizer
      第69回日本薬理学会北部会
    • Invited
    • Data Source
      KAKENHI-PLANNED-26117003

  • [Presentation] [18F]THK-5351のoff-target bindingの解析：画像病理相関症例を含めて2017
    • Author(s)
      原田龍一、石木愛子、甲斐英朗、佐藤直美、古川勝敏、冨田尚希、古本祥三、笹野公伸、工藤幸司、北本哲之、谷内一彦 、荒井啓行 、岡村信行
    • Organizer
      第36回日本認知症学会
    • Data Source
      KAKENHI-PLANNED-26117003

  • [Presentation] Characterizing the “off-target” binding of 18F-THK5351 in Alzheimer’s disease: correlation between ante-mortem and post-mortem findings.2017
    • Author(s)
      Harada R, Ishiki A, Furumoto S, Furukawa K, Tashiro M, Arai H, YanaiK, Kudo Y, Okamura N
    • Organizer
      11th Human Amyloid Imaging
    • Place of Presentation
      Miami, USA
    • Year and Date
      2017-01-11
    • Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-26117003

  • [Presentation] 新規遺伝子ノックアウトマウスを用いた脳内ヒスタミンクリアランス系の解明2017
    • Author(s)
      吉川雄朗、谷内一彦
    • Organizer
      第90回日本薬理学会年会
    • Place of Presentation
      長崎（ブリックホール）
    • Year and Date
      2017-03-15
    • Data Source
      KAKENHI-PROJECT-26253016

  • [Presentation] Successful reduction of off-target binding of quinoline derivatives as tau-selective PET tracers.2017
    • Author(s)
      Harada R, Hayakawa Y, Ezura M, Furumoto S, Iwata R, Arai H, Yanai K, Kudo Y, Okamura N.
    • Organizer
      AAIC 2017
    • Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-26117003

  • [Presentation] 骨格筋におけるヘパラン硫酸の役割について2017
    • Author(s)
      吉川雄朗、茂木明日香、松澤拓郎、三浦大和、中村正帆、谷内一彦
    • Organizer
      第68回日本薬理学会北部会
    • Data Source
      KAKENHI-PROJECT-26253016

  • [Presentation] タウイメージング18F-THK5351 PETの画像病理相関解析2017
    • Author(s)
      原田龍一、石木愛子、甲斐英朗、佐藤直美、古川勝敏、冨田尚希、谷内一彦、岡村信行、工藤幸司、荒井啓行
    • Organizer
      第28回日本老年医学会東北地方会
    • Data Source
      KAKENHI-PLANNED-26117003

  • [Presentation] 脳内ヒスタミン神経系の過剰な興奮はH2受容体を介してマウスの攻撃性を増加させる2017
    • Author(s)
      吉川雄朗、飯田智光、長沼史登、中村正帆、岡村信行、谷内一彦
    • Organizer
      第39回日本生物学的精神医学会・第47回日本神経精神薬理学会合同年会
    • Data Source
      KAKENHI-PROJECT-26253016

  • [Presentation] 時間分解蛍光法用ランタニド錯体標識βシートリガンドの開発2017
    • Author(s)
      原田龍一、岡村信行、古本祥三、吉川雄朗、工藤幸司、谷内一彦
    • Organizer
      第90回日本薬理学会
    • Place of Presentation
      長崎新聞文化ホール(長崎）
    • Data Source
      KAKENHI-PLANNED-26117003

  • [Presentation] CHARACTERIZATION OF 18F-BF227 IN A MOUSE MODEL VIA STEREOTAXIC INJECTION OF α-SYNUCLEIN AGGREGATES2017
    • Author(s)
      Michael E.J. Stouthandel, Ryuichi Harada, Yoshimi Hayakawa, Takeo Yoshikawa, Shozo Furumoto, Yukitsuka Kudo, Nobuyuki, Okamura, Kazuhiko Yanai
    • Organizer
      第90回日本薬理学会
    • Place of Presentation
      長崎新聞文化ホール(長崎）
    • Data Source
      KAKENHI-PLANNED-26117003

  • [Presentation] THE EFFECT OF H3 RECEPTOR ANTAGONIST ON NEUROPATHIC PAIN2017
    • Author(s)
      T Nakamura, T Matsuzawa, M Mogilevskaya, A Mogi, T Yoshikawa, F Naganuma, N Okamura, K Yanai
    • Organizer
      Histamine 2017
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26253016

  • [Presentation] 神経障害性疼痛に対するヒスタミンH3受容体拮抗薬の効果2017
    • Author(s)
      吉川雄朗、松澤拓郎、茂木明日香、Maria Mogilevskaya、中村正帆、谷内一彦
    • Organizer
      第90回日本薬理学会年会
    • Place of Presentation
      長崎（ブリックホール）
    • Year and Date
      2017-03-15
    • Data Source
      KAKENHI-PROJECT-26253016

  • [Presentation] [18F]THK-5351のアルツハイマー病患者における画像病理相関解析2017
    • Author(s)
      原田龍一、石木愛子、甲斐英朗、佐藤直美、古本祥三、笹野公伸、工藤幸司、北本哲之、谷内一彦、荒井啓行、岡村信行
    • Organizer
      第57回 日本核医学会学術総会
    • Data Source
      KAKENHI-PLANNED-26117003

  • [Presentation] ヒスタミン3型受容体インバースアゴニストはミクログリア機能を抑制しうつ様行動を改善する2017
    • Author(s)
      飯田智光、吉川雄朗、谷内一彦
    • Organizer
      第21回日本ヒスタミン学会
    • Data Source
      KAKENHI-PROJECT-26253016

  • [Presentation] Distinct patterns of [18F]THK-5351 retention in AD and non-AD tauopathies.2016
    • Author(s)
      Okamura N, Kikuchi A, Furukawa K, Ishiki A, Harada R, Hasegawa T, Takeda A, Furumoto S, Iwata R, Tashiro M, Yanai K, Aoki M, Arai H, Kudo Y.
    • Organizer
      The 10th Human Amyloid Imaging (HAI) meeting
    • Place of Presentation
      Miami, USA
    • Year and Date
      2016-01-13
    • Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-26117003

  • [Presentation] 膵β細胞におけるヘパラン硫酸の重要性2016
    • Author(s)
      松澤拓郎、吉川雄朗、中村正帆、谷内一彦
    • Organizer
      第89回日本薬理学会年会
    • Place of Presentation
      横浜（パシフィコ横浜）
    • Year and Date
      2016-03-09
    • Data Source
      KAKENHI-PROJECT-26253016

  • [Presentation] マウスにおけるヒスタミン神経系とイソフルラン麻酔の相互作用について2016
    • Author(s)
      中村正帆、吉川雄朗、長沼史登、飯田智光、三浦大和、Aniko Karpati、望月貴年、谷内一彦
    • Organizer
      第89回日本薬理学会年会
    • Place of Presentation
      横浜（パシフィコ横浜）
    • Year and Date
      2016-03-09
    • Data Source
      KAKENHI-PROJECT-26253016

  • [Presentation] Importance of histamine N-methyltransferase in brain functions2016
    • Author(s)
      Takeo Yoshikawa, Fumito Naganuma, Tadaho Nakamura, Takatoshi Mochizuki, Tomomitsu Iida, Aniko Karpati, Takuro Matsuzawa, Kazuhiko Yanai
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      横浜（パシフィコ横浜）
    • Year and Date
      2016-07-20
    • Data Source
      KAKENHI-PROJECT-26253016

  • [Presentation] Metabolite analysis of tau PET tracer [18F]THK-5351.2016
    • Author(s)
      Harada R, Okamura N, Furumoto S, Tago T, Furukawa K, Ishiki A, Iwata R, Tashiro M, Arai H, Yanai K, Kudo Y.
    • Organizer
      The 10th Human Amyloid Imaging (HAI) meeting
    • Place of Presentation
      Miami, USA
    • Year and Date
      2016-01-13
    • Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-26117003

  • [Presentation] Electroencephalogram of H1KO mice under isoflurane anesthesia.2016
    • Author(s)
      Tadaho, Nakamura, Takeo Yoshikawa, Fumito Naganuma, Tomomitsu Iida, Aniko Karpati, Toru Tamii, Nobuyuki Okamura, Kazuiko Yanai
    • Organizer
      European Histamine Research Society 45th annual meeting
    • Place of Presentation
      イタリア　フィレンツェ
    • Year and Date
      2016-05-11
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26253016

  • [Presentation] Longitudinal analysis of [18F]THK5351 tau PET images in patients with Alzheimer’s disease and corticobasal syndrome2016
    • Author(s)
      kamura N, Harada R, Ishiki A, Furukawa K, Kikuchi A, Hasegawa T, Aoki M, Furumoto S, Tashiro M, Yanai K, Arai H, Kudo Y
    • Organizer
      CTAD 2016
    • Place of Presentation
      San Diego, USA
    • Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-26117003

  • [Presentation] [F-18]THK5351 retention is associated with the progression of brain atrophy in patients with Alzheimer’s disease.2016
    • Author(s)
      Okamura N, Ishiki A, Furukawa K, Harada R, Tomita N, Furumoto S, Tashiro M, Yanai K, Arai H, Kudo Y.
    • Organizer
      AAIC2016
    • Place of Presentation
      Toronto, Canada
    • Year and Date
      2016-07-22
    • Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-26117003

  • [Presentation] Role of brain histamine in glutamate release from cultured astrocytes2016
    • Author(s)
      Aniko Karpati、吉川雄朗、中村正帆、長沼史登、飯田智光、三浦大和、谷内一彦
    • Organizer
      第89回日本薬理学会年会
    • Place of Presentation
      横浜（パシフィコ横浜）
    • Year and Date
      2016-03-09
    • Data Source
      KAKENHI-PROJECT-26253016

  • [Presentation] Histamine N-methyltransferase is important for the normal sleep-wake cycles and aggression through the regulation of brain histamine concentration.2016
    • Author(s)
      Fumito Naganuma, Takeo Yoshikawa, Tadaho Nakamura, Kazuhiko Yanai
    • Organizer
      30th CINP world congress of neuropsychopharmacology
    • Place of Presentation
      韓国　ソウル
    • Year and Date
      2016-07-03
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26253016

  • [Presentation] Histamine N-methyltransferaseの欠損はマウスにおいて睡眠覚醒サイクル異常と高い攻撃性を引き起こす2016
    • Author(s)
      長沼史登、吉川雄朗、中村正帆、堀米愛、三浦大和、矢内敦、望月貴年、谷内一彦
    • Organizer
      第89回日本薬理学会年会
    • Place of Presentation
      横浜（パシフィコ横浜）
    • Year and Date
      2016-03-09
    • Data Source
      KAKENHI-PROJECT-26253016

  • [Presentation] Role of histamine neurons in isoflurane anesthesia.2016
    • Author(s)
      Tadaho Nakamura, Takeo Yoshikawa, Fumito Naganuma, Tomomitsu Iida, Aniko Karpati, Toru Tamii, Nobuyuki Okamura, Kazuiko Yanai
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      横浜（パシフィコ横浜）
    • Year and Date
      2016-07-20
    • Data Source
      KAKENHI-PROJECT-26253016

  • [Presentation] Identification of wavelength-dependent compounds for imaging Lewy pathology2016
    • Author(s)
      Harada R, Okamura N, Furumoto S, Iwata R, Arai H, Yanai K, Kudo Y
    • Organizer
      AAIC2016
    • Place of Presentation
      Toronto, Canada
    • Year and Date
      2016-07-22
    • Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-26117003

  • [Presentation] 生体内ミクログリアにおける中枢ヒスタミン系の役割2015
    • Author(s)
      飯田智光、吉川雄朗、松澤拓郎、長沼史登、中村正帆、三浦大和、谷内一彦
    • Organizer
      第66回日本薬理学会北部会
    • Place of Presentation
      富山（富山国際会議場）
    • Year and Date
      2015-09-18
    • Data Source
      KAKENHI-PROJECT-26253016

  • [Presentation] 利益相反マネジメントはなぜ必要か？責任ある研究行為：知っておきたい利益相反＆オーサーシップ2015
    • Author(s)
      谷内一彦
    • Organizer
      第6回JANSセミナー
    • Place of Presentation
      AP東京八重洲通り　（東京都中央区）
    • Year and Date
      2015-06-21
    • Invited
    • Data Source
      KAKENHI-PROJECT-24243017

  • [Presentation] Molecular PET imaging of tau pathology in Alzheimer disease using THK tracers2015
    • Author(s)
      Yanai K, Okamura N
    • Organizer
      1st International Symposium of Brain Protein Aging and Dementia Control
    • Place of Presentation
      野依記念ホール（愛知県・名古屋市）
    • Year and Date
      2015-10-10
    • Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-26117003

  • [Presentation] Validation of the binding specificity of tau PET tracer [18F]THK-5351 on postmortem human brain samples.2015
    • Author(s)
      Harada R, Okamura N, Furumoto S, Ishiki A, Furukawa K, Tomita N, Tago T, Iwata R, Yanai K, Arai H, Kudo Y
    • Organizer
      AAIC 2015
    • Place of Presentation
      Washington D.C., USA
    • Year and Date
      2015-07-22
    • Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-26117003

  • [Presentation] Analysis of histamine N-methyltransferase deficient mice2015
    • Author(s)
      Naganuma F, Yoshikawa T, Nakamura T, Miura Y, Matsuzawa T, Yanai K
    • Organizer
      European Histamine Research Society 44th annual meeting
    • Place of Presentation
      スペイン（マラガ）
    • Year and Date
      2015-05-06
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26253016

  • [Presentation] Role of histamine in gliotransmitter release from astrocytes2015
    • Author(s)
      Aniko Karpati, Takeo Yoshikawa, Tadaho Nakamura, Fumito Naganuma, Tomomitsu Iida, Yamato Miura, Kazuhiko Yanai
    • Organizer
      第38回日本神経科学大会
    • Place of Presentation
      神戸（神戸国際会議場）
    • Year and Date
      2015-07-28
    • Data Source
      KAKENHI-PROJECT-26253016

  • [Presentation] H1-knocked out mouse had high sensitivity to isoflurane anesthesia2015
    • Author(s)
      Nakamura T, Yoshikawa T, Naganuma F, iida T, Miura Y, Yanai K
    • Organizer
      European Histamine Research Society 44th annual meeting
    • Place of Presentation
      スペイン（マラガ）
    • Year and Date
      2015-05-06
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26253016

  • [Presentation] 大学におけるCOIマネジメント：ゼロトレランスにしないための制度設計2015
    • Author(s)
      谷内一彦
    • Organizer
      第88回日本薬理学会年会
    • Place of Presentation
      名古屋国際会議場（愛知県名古屋市）
    • Year and Date
      2015-03-20
    • Data Source
      KAKENHI-PROJECT-24243017

  • [Presentation] Histamine N-methyltransferase deficiency induced the abnormal sleep-awake cycles and aggressive behavior in mice2015
    • Author(s)
      長沼史登、吉川雄朗、矢内敦、堀米愛、三浦大和、中村正帆、望月貴年、谷内一彦
    • Organizer
      第58回日本神経化学大会
    • Place of Presentation
      大宮（大宮ソニックシティ）
    • Year and Date
      2015-09-11
    • Data Source
      KAKENHI-PROJECT-26253016

  • [Presentation] マウス多基質性トランスポーターによるモノアミン輸送能の検討2015
    • Author(s)
      三浦大和、吉川雄朗、長沼史登、中村正帆、飯田智光、谷内一彦
    • Organizer
      第19回活性アミンに関するワークショップ
    • Place of Presentation
      いわき（小名浜オーシャンホテル）
    • Year and Date
      2015-08-20
    • Data Source
      KAKENHI-PROJECT-26253016

  • [Presentation] イソフルランの麻酔作用におけるヒスタミン神経系の役割2015
    • Author(s)
      中村正帆、吉川雄朗、長沼史登、三浦大和、飯田智光、松澤拓郎、堀米愛、Karpati Aniko、谷内一彦
    • Organizer
      第66回日本薬理学会北部会
    • Place of Presentation
      富山（富山国際会議場）
    • Year and Date
      2015-09-18
    • Data Source
      KAKENHI-PROJECT-26253016

  • [Presentation] Role of histaminergic neuronal system in isoflurane anesthesia2015
    • Author(s)
      Tadaho Nakamura, Takeo Yoshikawa, Fumito Naganuma, Osamu Kobayashi, Miho Kaneko, Masanori Yamauchi, Kazuhiko Yanai
    • Organizer
      Anesthesiology 2015
    • Place of Presentation
      アメリカ、サンディエゴ
    • Year and Date
      2015-10-24
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26253016

  • [Presentation] ヒスタミン研究に残された解決されるべき課題：脳内ヒスタミンの分解系を中心に2015
    • Author(s)
      谷内一彦、長沼史登、中村正帆、岡村信行、吉川雄朗
    • Organizer
      第19回活性アミンに関するワークショップ
    • Place of Presentation
      いわき（小名浜オーシャンホテル）
    • Year and Date
      2015-08-20
    • Invited
    • Data Source
      KAKENHI-PROJECT-26253016

  • [Presentation] Histamine N-methyltransferaseノックアウトマウスの行動解析2015
    • Author(s)
      長沼史登、吉川雄朗、中村正帆、三浦大和、堀米愛、谷内一彦
    • Organizer
      第24回神経行動薬理若手研究者の集い
    • Place of Presentation
      名古屋国際会議場（愛知県名古屋市）
    • Year and Date
      2015-03-17
    • Data Source
      KAKENHI-PROJECT-26253016

  • [Presentation] Preclinical characterization of [18F]THK-5117 enantiomers as a PET tau probe for tau pathology in Alzheimer’s disease2015
    • Author(s)
      Tago T., Furumoto S., Okamura N., Harada R., Adachi H., Ishikawa Y., Yanai Y., Iwata R., Kudo Y.
    • Organizer
      21st International Symposium on Radiopharmaceutical Sciences
    • Place of Presentation
      Columbia, USA
    • Year and Date
      2015-05-23
    • Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-26117003

  • [Presentation] Mechanism of brain histamine clearance2015
    • Author(s)
      吉川雄朗、長沼史登、三浦大和、矢内敦、堀米愛、中村正帆、望月貴年、谷内一彦
    • Organizer
      第38回日本神経科学大会
    • Place of Presentation
      神戸（神戸国際会議場）
    • Year and Date
      2015-07-28
    • Data Source
      KAKENHI-PROJECT-26253016

  • [Presentation] Histamine N-methyltransferseノ欠損はマウスにおいて攻撃性を高め、睡眠サイクル異常を引き起こす2015
    • Author(s)
      長沼史登、吉川雄朗、堀米愛、三浦大和、中村正帆、矢内敦、望月貴年、谷内一彦
    • Organizer
      第37回日本生物学的精神医学会第45回日本精神神経薬理学会
    • Place of Presentation
      東京（タワーホール船橋）
    • Year and Date
      2015-09-24
    • Data Source
      KAKENHI-PROJECT-26253016

  • [Presentation] Distribution of tau pathology in the patients with mild cognitive impairment and Alzheimer’s disease measured with [18F]THK-5351 PET.2015
    • Author(s)
      Okamura N, Furumoto S, Furukawa K, Ishiki A, Tomita N, Harada R, Tashiro M, Yanai K, Arai H, Kudo Y.
    • Organizer
      AAIC2015
    • Place of Presentation
      Washington D.C., USA
    • Year and Date
      2015-07-22
    • Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-26117003

  • [Presentation] HistamineN-methyltransferaseノックアウトマウスの解析2015
    • Author(s)
      長沼史登、吉川雄朗、谷内一彦他
    • Organizer
      第８８回日本薬理学会
    • Place of Presentation
      名古屋国際会議場（名古屋）
    • Year and Date
      2015-03-18
    • Data Source
      KAKENHI-PROJECT-26670117

  • [Presentation] PET imaging of tau pathology in mild cognitive impairment and Alzheimer's disease with [18F]THK-5351.2015
    • Author(s)
      Okamura N, Furumoto S, Furukawa K, Ishiki A, Harada R, Iwata R, Tashiro M, Yanai K, Arai H, Kudo Y.
    • Organizer
      SNMMI 2015 Annual Meeting
    • Place of Presentation
      Baltimore, USA
    • Year and Date
      2015-06-08
    • Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-26117003

  • [Presentation] Characterization of [18F]THK-5351, a novel PET tracer for imaging tau pathology in Alzheimer's disease.2014
    • Author(s)
      Okamura N, Furumoto S, Harada R, Tago T, Iwata R, Tashiro M, Furukawa K, Arai H, Yanai K, Kudo Y.
    • Organizer
      EANM 2014
    • Place of Presentation
      Gothenburg, Sweden
    • Year and Date
      2014-10-21
    • Data Source
      KAKENHI-PLANNED-26117003

  • [Presentation] 脳内ヒスタミン研究におけるマイクロダイアリシスの使用について2014
    • Author(s)
      吉川雄朗、中村正帆、長沼史登、三浦大和、谷内一彦
    • Organizer
      第２５回マイクロダイアリシス研究会
    • Place of Presentation
      お茶の水女子大学（東京都文京区）
    • Year and Date
      2014-12-20
    • Invited
    • Data Source
      KAKENHI-PROJECT-26253016

  • [Presentation] マウスにおける低親和性トランスポーターの輸送能解析2014
    • Author(s)
      三浦大和、吉川雄朗、谷内一彦ほか
    • Organizer
      第18回日本ヒスタミン学会
    • Place of Presentation
      都ホテルニューアルカイック（尼崎）
    • Year and Date
      2014-10-10
    • Data Source
      KAKENHI-PROJECT-26670117

  • [Presentation] Antihistamine Update2013
    • Author(s)
      Kazuhiko Yanai
    • Organizer
      第63回日本アレルギー学会秋季学術大会,日本国内学会
    • Place of Presentation
      東京、日本[基調講演:英語発表]
    • Data Source
      KAKENHI-PROJECT-24659255

  • [Presentation] Villemagne. Molecular imaging of disease-related pathology in neurodegenerative disorders2013
    • Author(s)
      Kazuhiko Yanai
    • Organizer
      The 12^<th> meeting of the Asia Pacific Federation of Pharamacolouists (APFP),海外・国際研究会
    • Place of Presentation
      上海、中国[特別講演・招待講演:英語発表]
    • Invited
    • Data Source
      KAKENHI-PROJECT-24659255

  • [Presentation] タウイメージングプローブ候補化合物F18標識アリールキノリン誘導体の前臨床評価2013
    • Author(s)
      原田龍一、岡村信行、古本祥三、多胡哲郎、吉川雄朗、荒井啓行、岩田錬、谷内一彦、工藤幸司
    • Organizer
      第８６回日本薬理学会
    • Place of Presentation
      福岡
    • Data Source
      KAKENHI-PROJECT-24659255

  • [Presentation] Molecular imaging of disease-related pathology in neurodegerative dementia2012
    • Author(s)
      Kazuhiko Yanai and Nobuyuki Okamura
    • Organizer
      The 21st Korea-Japan Joint Seminar on Pharmacology
    • Place of Presentation
      Jeju, Korea
    • Invited
    • Data Source
      KAKENHI-PROJECT-24659255

  • [Presentation] Molecular imaging of disease-related pathology in neurodegenerative dementia2012
    • Author(s)
      Kazuhiko Yanai
    • Organizer
      The 21st Korea-Japan Joint Seminar on Pharmacology,海外・国際研究会
    • Place of Presentation
      チェジュ島、韓国[特別講演・招待講演:英語発表]
    • Invited
    • Data Source
      KAKENHI-PROJECT-24659255

  • [Presentation] アルツハイマー病の病理画像化を目指したF-18標識PETプローブの開発2012
    • Author(s)
      古本祥三、岡村信行、樋口真人、岩田錬、工藤幸司、谷内一彦
    • Organizer
      第85回日本薬理学会
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-21390171

  • [Presentation] ヒスタミンH3受容体による膵β細胞機能の制御2012
    • Author(s)
      中村正帆、吉川雄朗、野口直哉、長沼史登、原田龍一、アタイエフモーセン、飯田智光、笠島敦子、笹野公伸、谷内一彦
    • Organizer
      第85回日本薬理学会
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-21390171

  • [Presentation] Plasma membrane monoamine transporter (PMAT) is important for monoamine clearance by human astrocytoma-derived cell line, 1321N1 cells2012
    • Author(s)
      Fumito Naganuma, Takeo Yoshikawa, Tomomitsu Iida, and Kazuhiko Yanai
    • Organizer
      The 21st Korea-Japan Joint Seminar on Pharmacology
    • Place of Presentation
      Jeju, Korea
    • Data Source
      KAKENHI-PROJECT-24659255

  • [Presentation] 受容体遮断は睡眠除去した野生型とH1受容体遺伝子ノックアウトマウスで自発運動量を増加させる2012
    • Author(s)
      アタイエフモーセン、長沼史登、渋谷勝彦、中村正帆、吉川雄朗、岡村信行、谷内一彦
    • Organizer
      第85回日本薬理学会
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-21390171

  • [Presentation] H3 receptor blockade increases locomotor activity in mice2012
    • Author(s)
      Attayeb Mohsen, Fumito Naganuma, Tadaho Nakamura, Katsuhiko Shibuya, Takeo Yoshikawa, Kazuhiku Yanai
    • Organizer
      JSPS-NRF Asian Science Seminar
    • Place of Presentation
      ソウル韓国
    • Data Source
      KAKENHI-PROJECT-21390171

  • [Presentation] [18F] THK-523によるin vivoタウイメージング2012
    • Author(s)
      原田龍一、岡村信行、古本祥三、吉川雄朗、荒井啓行、谷内一彦、工藤幸司
    • Organizer
      第85回日本薬理学会
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-21390171

  • [Presentation] Histamine H3 Receptor Regulates the Functions of Pancreatic β-cell2012
    • Author(s)
      adaho Nakamura, Takeo Yoshikawa, Fumito Naganuma, Ryuichi Harada, Attayeb Mohsen, Masashi Saito, and Kazuhiko Yanai
    • Organizer
      JSPS-NRF Asian Science Seminar
    • Place of Presentation
      ソウル韓国
    • Data Source
      KAKENHI-PROJECT-21390171

  • [Presentation] Interaction of histamine and calcitonin gene-related peptide in the formalin-induced pain perception in rats2012
    • Author(s)
      Jalal Izadi Mobarakeh, Kazuhiro Takahashi, Kazuo Nunoki and Kazuhiko Yanai
    • Organizer
      JSPS-NRF Asian Science Seminar
    • Place of Presentation
      ソウル韓国
    • Data Source
      KAKENHI-PROJECT-21390171

  • [Presentation] Neuroimaging evaluation of regional brain responses to alternative therapies : [18F] FDG PET studies2012
    • Author(s)
      Tashiro M, Ogura T, Sugawara A, Duan X, Masud M, Watanuki S, Itoh M, Yanai K
    • Organizer
      European Conference of Radiology(ECR)
    • Place of Presentation
      Vienna, Austria
    • Data Source
      KAKENHI-PROJECT-21590754

  • [Presentation] 小動物用PET/CTを用いた抗ヒスタミン薬レボセチリジンの鎮静性評価2012
    • Author(s)
      飯田智光、古本祥三、船木善仁、石渡喜一、長沼史登、原田龍一、岩田錬、谷内一彦
    • Organizer
      第85回日本薬理学会
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-21390171

  • [Presentation] Cholinergic deficit and response to donepezil therapy in Parkinson's disease with dementia2012
    • Author(s)
      Kotaro Hiraoka, Nobuyuki Okamura, Yoshihito Funaki, Akiko Hayashi, Manabu Tashiro, Kinya Hisanaga, Toshikatsu Fujii, Atsushi Takeda, Kazuhiko Yanai, Ren Iwata, and Etsuro Mori
    • Organizer
      SPS-NRF Asian Science Seminar
    • Place of Presentation
      ソウル韓国
    • Data Source
      KAKENHI-PROJECT-21390171

  • [Presentation] ヒトアストロサイト-マ由来細胞株はPMATを介してドパミンを取り込む2012
    • Author(s)
      長沼史登、吉川雄朗、中村正帆、飯田智光、谷内一彦
    • Organizer
      第85回日本薬理学会
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-21390171

  • [Presentation] 正常ヒトアストロサイトによるヒスタミン取り込みはPMATを介して行われる2012
    • Author(s)
      吉川雄朗、長沼史登、中村正帆、飯田智光、谷内一彦
    • Organizer
      第85回日本薬理学会
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-21390171

  • [Presentation] ヒスタミンH4受容体を介するケモタキシスにおける低分子量Gタンパク質Racの関与2012
    • Author(s)
      倉増敦朗、若林深恵、乾誠、谷内一彦
    • Organizer
      第85回日本薬理学会
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-21390171

  • [Presentation] Histamine H1 receptor occupancy of new generation antidepressant : in vivo positron emission tomography study2012
    • Author(s)
      Hirotoshi Sato, Chihiro Ito, Manabu Tashiro, Katsuhiko Shibuya, Zhang Dongying, Kotaro Hiraoka, Yoshihito Funaki, Ren Iwata, Hiroo Matsuoka and Kazuhiko Yanai
    • Organizer
      JSPS-NRF Asian Science Seminar
    • Place of Presentation
      ソウル韓国
    • Data Source
      KAKENHI-PROJECT-21390171

  • [Presentation] Neuroimaging evaluation of regional brain responses to alternative therapies : [^<18>F]FDG PET studies2012
    • Author(s)
      M.Tashiro, T.Ogura, A.Sugawara, X.Duan, M.M.Masud, S.Watanuki, M.Itoh, K.Yanai
    • Organizer
      European Conference of Radiology (ECR)
    • Place of Presentation
      Vienna, Austria
    • Data Source
      KAKENHI-PROJECT-21590754

  • [Presentation] アルツハイマー病患者における脳内アセチルコリンエステラーゼへの[11C] ドネぺジル結合量と塩酸ドネぺジル治療反応性との関連性2012
    • Author(s)
      岡村信行、糟谷昌志、石川博康、田中尚文、船木善仁、岩田錬、目黒謙一、谷内一彦
    • Organizer
      第85回日本薬理学会
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-21390171

  • [Presentation] 遺伝子・組織バンクと医療情報の電子化2012
    • Author(s)
      谷内一彦
    • Organizer
      第33回日本臨床薬理学会,日本国内学会
    • Place of Presentation
      沖縄、日本[基調講演]
    • Data Source
      KAKENHI-PROJECT-24659255

  • [Presentation] Wavelength-dependent detection of senile plaques and neurofibrillary tangles with novel fluorescent probes2012
    • Author(s)
      Ryuichi Harada, Nobuyuki Okamura, Shozo Furumoto, Takeo Yoshikawa, Yukitsuka Kudo, Kazuhiko Yanai
    • Organizer
      JSPS-NRF Asian Science Seminar
    • Place of Presentation
      ソウル韓国
    • Data Source
      KAKENHI-PROJECT-21390171

  • [Presentation] Potential Central Sedative Effects of Antihistamine Eye-drops : Histamine H1 Receptor Occupancy by PET2012
    • Author(s)
      Dongying Zhang, Manabu Tashiro, Nobuyuki Okamura, and Kazuhiko Yanai
    • Organizer
      第32回日本臨床薬理学会
    • Place of Presentation
      浜松
    • Data Source
      KAKENHI-PROJECT-21390171

  • [Presentation] The Distribution Change of Trace Metal in Methamphetamine Treated Mice Brain Slices by In-Air Micro-PIXE JSPS-NRF Asian Science Seminar2012
    • Author(s)
      Eiko Sakurai, Keizo Ishii, Takahiro Satoh, Tomohiro Kamiya, Nobuyuki Okamura, Kazuhiko Yanai
    • Place of Presentation
      ソウル韓国
    • Data Source
      KAKENHI-PROJECT-21390171

  • [Presentation] Histamine H3 receptors antagonists increase anxiogenic-like behaviors and locomotor activity2011
    • Author(s)
      Attayef Mohsen, Fumito Naganuma, Tadaho Nakamura, Katsuhiko Shibuya, Takeo Yoshikawa, Nobuyuki Okamura, and Kazuhiko Yanai
    • Organizer
      第62回日本薬理学会北部会
    • Place of Presentation
      仙台
    • Data Source
      KAKENHI-PROJECT-21390171

  • [Presentation] 正常ヒトアストロサイトによるヒスタミン取り込み機構の解明2011
    • Author(s)
      長沼史登、吉川雄朗、中村正帆、井筒敏恵、谷内一彦
    • Organizer
      第15回日本ヒスタミン学会
    • Place of Presentation
      盛岡
    • Data Source
      KAKENHI-PROJECT-21390171

  • [Presentation] 膵β細胞におけるヒスタミン3型受容体の発現とインスリン分泌での役割2011
    • Author(s)
      中村正帆、大杉真也、吉川雄朗、谷内一彦
    • Organizer
      第62回日本薬理学会北部会
    • Place of Presentation
      仙台
    • Data Source
      KAKENHI-PROJECT-21390171

  • [Presentation] Locomotor activity and anxiolytic-like behaviors are increased by histamine H3 receptor antagonists2011
    • Author(s)
      ttayef Mohsen, Fumito Naganuma, Tadaho Nakamura, Katsuhiko Shibuya, Takeo Yoshikawa, Nobuyuki Okamura, and Kazuhiko Yanai
    • Organizer
      第15回日本ヒスタミン学会
    • Place of Presentation
      盛岡
    • Data Source
      KAKENHI-PROJECT-21390171

  • [Presentation] PETによる新規抗うつ薬(NaSSA・SSRI)のヒト脳内H1受容体占拠率の解析2011
    • Author(s)
      佐藤博俊、伊藤千裕、田代学、渋谷勝彦、張冬頴、平岡宏太良、船木善仁、岩田錬、谷内一彦、松岡洋夫
    • Organizer
      第41回日本神経精神薬理学会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-21390171

  • [Presentation] ヒスタミンH4受容体を介するケモタキシスに図5.脾臓の骨髄由来抑制細胞数の比較おける低分子量Gタンパク質Racの関与2011
    • Author(s)
      倉増敦朗、若林深恵、乾誠、谷内一彦
    • Organizer
      第85回日本薬理学会年会
    • Place of Presentation
      京都国立京都国際会館
    • Year and Date
      2011-03-14
    • Data Source
      KAKENHI-PROJECT-21590268

  • [Presentation] Molecular PET Imaging of Histamine H1 Receptors in Humans : Recent Progress2011
    • Author(s)
      Fumito Naganuma, Kazuhiko Yanai, and Manabu Tashiro
    • Organizer
      Anxiety and Depression, SFN2011
    • Place of Presentation
      DC米国
    • Data Source
      KAKENHI-PROJECT-21390171

  • [Presentation] ヒトアストロサイトによるヒスタミン取り込み機構2011
    • Author(s)
      長沼史登、吉川雄朗、中村正帆、井筒敏恵、谷内一彦
    • Organizer
      第62回日本薬理学会北部会
    • Place of Presentation
      仙台
    • Data Source
      KAKENHI-PROJECT-21390171

  • [Presentation] 用手療法の有用性に関するFDG-PET研究2011
    • Author(s)
      小倉毅, 田代学, メヘディ・マスード, 四月朔日聖一, 平岡宏太良, 渋谷勝彦, 谷内一彦, 山口慶一郎, 伊藤正敏
    • Organizer
      日本核医学会学術総会
    • Place of Presentation
      つくば市
    • Data Source
      KAKENHI-PROJECT-21590754

  • [Presentation] インスリン分泌膵β細胞におけるヒスタミン3型受容体の発現と機能2011
    • Author(s)
      中村正帆、吉川雄朗、野口直哉、大杉真也、笠島敦子、笹野公伸、谷内一彦
    • Organizer
      第15回日本ヒスタミン学会
    • Place of Presentation
      盛岡
    • Data Source
      KAKENHI-PROJECT-21390171

  • [Presentation] ヒスタミン研究の最近の進歩2011
    • Author(s)
      谷内一彦
    • Organizer
      第15回日本ヒスタミン学会
    • Place of Presentation
      盛岡
    • Data Source
      KAKENHI-PROJECT-21390171

  • [Presentation] 用手療法の有用性に関するFDG-PET研究2011
    • Author(s)
      小倉毅, 田代学, メヘディ・マスード, 四月朔日聖一, 平岡宏太良, 渋谷勝彦, 谷内一彦, 山口慶一郎, 伊藤正敏
    • Organizer
      日本核医学会学術総会
    • Place of Presentation
      茨城県つくば市
    • Data Source
      KAKENHI-PROJECT-21590754

  • [Presentation] ヒトアストロサイトによるヒスタミン取り込み機構について2011
    • Author(s)
      長沼史登、吉川雄朗、中村正帆、井筒敏恵、谷内一彦
    • Organizer
      第54回日本神経化学大会
    • Place of Presentation
      仙台
    • Data Source
      KAKENHI-PROJECT-21390171

  • [Presentation] Measurement of histamine release change in living human brain associated with stress and circadian rhythm2010
    • Author(s)
      Shibuya K, Tashiro M, Watanuki S, Masud M, Miyake M, Kumagai K, Ishikawa Y, Iwata R, Yanai K
    • Organizer
      6th World Congress of Biomechanics and 14th International Conference on Biomedical Engineering
    • Place of Presentation
      Singapore
    • Data Source
      KAKENHI-PROJECT-21590754

  • [Presentation] Functional and molecular imaging using positron emission tomography at Tohoku University : application to for health sciences.2010
    • Author(s)
      Tashiro M, Miyake M, Masud MM, Watanuki S, Okamura N, Yanai K, Fukuda H.
    • Organizer
      SMART-Tohoku GCOE joint Workshop on Micro & Nano Bioengineering
    • Place of Presentation
      Singapore, Singapore
    • Data Source
      KAKENHI-PROJECT-21590754

  • [Presentation] Pharmacokinetics of a new 18F-labeled amyloid imaging agent, [18F]FACT, in Alzheimer's disease patients2010
    • Author(s)
      Tashiro M, Okamura N, Watanuki S, Furumoto S, Furukawa K, Funaki Y, Iwata R, Kudo Y, Arai H, Yanai K
    • Organizer
      World Molecular Imaging Conference 2010
    • Place of Presentation
      Kyoto, Japan
    • Data Source
      KAKENHI-PROJECT-21590754

  • [Presentation] PETイメージングと創薬2010
    • Author(s)
      谷内一彦
    • Organizer
      日本学術会議シンポジウム:創薬の促進を目指したトランスレーショナルリサーチの推進における医療系薬学研究者の役割
    • Place of Presentation
      日本学術会議講堂
    • Year and Date
      2010-06-11
    • Data Source
      KAKENHI-PROJECT-21650088

  • [Presentation] Scientific Evaluation on Effects of Chiropractic Treatment, a Type of Manual Therapy, using Magnetic Resonance Imaging(MRI)and Positron Emission Tomography(PET)2010
    • Author(s)
      Ogura T, Tashiro M, Masud M, Watanuki S, Shibuya K, Itoh M, Fukuda H, Yanai K
    • Organizer
      6th World Congress of Biomechanics and 14th International Conference on Biomedical Engineering
    • Place of Presentation
      Singapore
    • Data Source
      KAKENHI-PROJECT-21590754

  • [Presentation] CONGAコンセンサスに準じた抗ヒスタミン薬の薬理学的評価2010
    • Author(s)
      谷内一彦
    • Organizer
      第60回日本アレルギー学会秋季学術大会
    • Place of Presentation
      東京
    • Year and Date
      2010-11-25
    • Data Source
      KAKENHI-PROJECT-21390171

  • [Presentation] Quantitative Analysis of amyloid b deposition in the brain of Alzheimer's disease patients using PET with [11C]BF-227 and [18F]FACT2010
    • Author(s)
      Tashiro M, Okamura N, Furumoto S, Watanuki S, Kumagai K, Furukawa K, Funaki Y, Kimura Y, Iwata R, Kudo Y, Arai H, Watabe H, Yanai K
    • Organizer
      World Congress on Biomechanics
    • Place of Presentation
      Singapore, Singapore
    • Data Source
      KAKENHI-PROJECT-21590754

  • [Presentation] Pharmacokinetics of [18F]FACT, a new 18F-labeled amyloid imaging agent, in the brain Alzheimer's disease patients. Annual Meeting of EANM2010
    • Author(s)
      Tashiro M, Okamura N, Watanuki S, Furumoto S, Furukawa K, Funaki Y, Iwata R, Kudo Y, Arai H, Yanai K
    • Organizer
      Annual Meeting of EANM
    • Place of Presentation
      Vienna, Austria
    • Data Source
      KAKENHI-PROJECT-21590754

  • [Presentation] Quantitative Analysis of amyloid beta deposition in the brain of Alzheimer's disease patients using PET and [11C]BF-2272010
    • Author(s)
      Tashiro M, Okamura N, Watanuki S, Furumoto S, Furukawa K, Funaki Y, Iwata R, Kudo Y, Arai H, Yanai K
    • Organizer
      Annual Meeting of EANM
    • Place of Presentation
      Vienna, Austria
    • Data Source
      KAKENHI-PROJECT-21590754

  • [Presentation] [^<11>C]BF-227 PET Study in Protein Conformational Diseases2009
    • Author(s)
      N.Okamura, S.Furumoto, M.Tashiro, Y.Funaki, A.Kikuchi, Y Shiga, K.Furukawa, H.Arai, K.Doh-Ura, R.Iwata, K.Yanai, Y.Kudo
    • Organizer
      Ann.Congress Eur.Assoc.Nucl.Med.
    • Place of Presentation
      Barcelona, Spain
    • Data Source
      KAKENHI-PROJECT-19390311

  • [Presentation] Molecular Imaging of acetylcholine esterase and amyloid deposits in Alzheimer disease2009
    • Author(s)
      Yanai K, Okamura N.
    • Organizer
      22th International Society of Neurochemistry (ISN/APSN2009)
    • Place of Presentation
      プサン、韓国
    • Data Source
      KAKENHI-PROJECT-21390171

  • [Presentation] ヒト脳内ヒスタミンH1受容体の男女差 : PET研究2009
    • Author(s)
      加藤元久、田代学、吉沢正彦, 張冬頴, 岡村信行, 福土審, 谷内一彦
    • Organizer
      第82回日本薬理学会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-19390061

  • [Presentation] Molecular Imaging of acetylcholine esterase and amyloid deposits in Alzheimer disease.2009
    • Author(s)
      Yanai K, Okamura N.
    • Organizer
      22th International Society of Neurochemistry (ISN/APSN2009)
    • Place of Presentation
      プサン、韓国
    • Data Source
      KAKENHI-PROJECT-21650088

  • [Presentation] [^<18>F]FACT PET is Useful for Noninvasive Detection of Amyloid Plaques in Alzheimer's Disease2009
    • Author(s)
      K. Sugi, N. Okamura, S. Furumoto, M. Tashiro, K. Furukawa, Y. Funaki, H. Arai, Y. Kudo, R. Iwata, K. Yanai
    • Organizer
      欧州核医学会
    • Place of Presentation
      バルセロナ
    • Data Source
      KAKENHI-PROJECT-19390311

  • [Presentation] 抗ヒスタミン薬の最新科学 : インペアード・パフォーマンスを中心に2009
    • Author(s)
      谷内一彦
    • Organizer
      日本薬理学会
    • Place of Presentation
      日本薬理学会・横浜
    • Year and Date
      2009-03-16
    • Data Source
      KAKENHI-PROJECT-19390061

  • [Presentation] 脳スライスからの内因性モノアミン同時遊離測定法の開発 : ヒスタミン受容体遺伝子ノックアウトマウスへの応用2009
    • Author(s)
      張冬頴, 櫻井映子, 瀧野奈緒子, 谷内一彦
    • Organizer
      第82回日本薬理学会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-19390061

  • [Presentation] Human functional imaging of skeletal muscles and brain during sports activity using positron emission tomography.2009
    • Author(s)
      Tashiro M, Masud MM, Jeong M, Fujimoto T, Miyake M, Watanuki S, Itoh M, Yanai K.
    • Organizer
      Global COE Session, Annual Meeting of Asia-Pacific Association of Biomechanics.
    • Place of Presentation
      Christchurch, Newzealand
    • Data Source
      KAKENHI-PROJECT-21590754

  • [Presentation] ヒスタミンH3受容体の細胞表面発現調節2009
    • Author(s)
      助川淳, 木下和樹, 高柳詩織, 佐藤岳哉, 前田恵, 原口満也, 谷内一彦, 福永浩司, 柳澤輝行
    • Organizer
      第82回日本薬理学会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-19390061

  • [Presentation] I-125標識ヒト化二重特異性低分子抗体Ex3の動態評価2009
    • Author(s)
      古本祥三, 浅野竜太郎, 窪田和雄, 谷内一彦, 岩田錬, 熊谷泉
    • Organizer
      第49回日本核医学会学術総会
    • Place of Presentation
      旭川
    • Year and Date
      2009-10-02
    • Data Source
      KAKENHI-PROJECT-19390311

  • [Presentation] ヒスタミンH4受容体を介するケモタキシスにおける低分子量Gタンパク質Racの関与2009
    • Author(s)
      倉増敦朗、若林深恵、谷内一彦
    • Organizer
      第64回日本薬理学会西南部会
    • Place of Presentation
      福岡KKRホテル博多
    • Year and Date
      2009-11-20
    • Data Source
      KAKENHI-PROJECT-21590268

  • [Presentation] Human functional and molecular imaging using positron emission tomography(PET)for health promotion sciences2009
    • Author(s)
      Tashiro M, Masud MM, Jeong M, Fujimoto T, Miyake M, Watanuki S, Itoh M, Yanai K
    • Organizer
      3rd International Symposium of Nanomedicine(ISNM2009)
    • Place of Presentation
      Okazaki, Aichi
    • Data Source
      KAKENHI-PROJECT-21590754

  • [Presentation] Human functional and molecular imaging using positron emission tomography(PET)for health promotion sciences.2009
    • Author(s)
      Tashiro M, Masud MM, Jeong M, Fujimoto T, Miyake M, Watanuki S, Itoh M, Yanai K.
    • Organizer
      3rd International Symposium of Nanomedicine (ISNM2009).
    • Place of Presentation
      Okazaki
    • Data Source
      KAKENHI-PROJECT-21590754

  • [Presentation] Measurement of brain histamine H_1 receptor occupancy following treatment with various antihistamines using PET with ^<11>C-doxepin : dose dependency of cetirizine hydrochloride2009
    • Author(s)
      M. Tashiro, M. Miyake, S. Watanuki, Y. Funaki, Y. Ishikawa, R. Iwata, K. Yanai
    • Organizer
      2009年世界分子イメージング学会
    • Place of Presentation
      モントリオール
    • Data Source
      KAKENHI-PROJECT-19390311

  • [Presentation] [^<18>F]FACT PET is Useful for Noninvasive Detection of Amyloid Plaques in Alzheimer's Disease2009
    • Author(s)
      K.Sugi, N.Okamura, S.Furumoto, M.Tashiro, K.Furukawa, Y.Funaki, H.Arai, Y.Kudo, R.Iwata, K.Yanai
    • Organizer
      Ann.Congress Eur.Assoc.Nucl.Med.
    • Place of Presentation
      Barcelona (Spain)
    • Data Source
      KAKENHI-PROJECT-19390311

  • [Presentation] 臨床応用を目指した^<11>C-ガランタミンの実用的標識合成法2009
    • Author(s)
      佐藤眞梨, 古本祥三, 石川洋一, 森雅憲, 青野嘉隆, 谷内一彦, 岩田錬
    • Organizer
      第49回日本核医学会学術総会
    • Place of Presentation
      旭川
    • Year and Date
      2009-10-01
    • Data Source
      KAKENHI-PROJECT-19390311

  • [Presentation] ヒスタミンH3受容体のヘリックス8はGタンパク質との共役に重要である2009
    • Author(s)
      倉増敦朗、助川淳、櫻井映子、渡邉建彦、柳澤輝行、谷内一彦
    • Organizer
      第62回日本薬理学会西南部会
    • Place of Presentation
      愛媛リジェール松山
    • Year and Date
      2009-11-27
    • Data Source
      KAKENHI-PROJECT-21590268

  • [Presentation] アルツハイマー病診断における[^<18>F]FACT-PETの有用性の検討2009
    • Author(s)
      岡村信行, 古本祥三, 田代学, 古川勝敏, 杉健太郎, 船木善仁, 岩田錬, 荒井啓行, 工藤幸司, 谷内一彦
    • Organizer
      第49回日本核医学会学術総会
    • Place of Presentation
      旭川
    • Year and Date
      2009-10-02
    • Data Source
      KAKENHI-PROJECT-19390311

  • [Presentation] [^<11>C]BF-227 PET Study in Protein Conformational Diseases2009
    • Author(s)
      N. Okamura, S. Furumoto, M. Tashiro, Y. Funaki, A. Kikuchi, Y Shiga, K. Furukawa, H. Arai, K. Doh-Ura, R. Iwata, K. Yanai, Y. Kudo
    • Organizer
      欧州核医学会
    • Place of Presentation
      バルセロナ
    • Data Source
      KAKENHI-PROJECT-19390311

  • [Presentation] Molecular PET imaging in Alzheimer disease: From basic development to clinical application2009
    • Author(s)
      Yanai K, Okamura N
    • Organizer
      4th Japan-China Joint Meeting of Basic and Clinical Pharmacology
    • Place of Presentation
      横浜
    • Year and Date
      2009-03-18
    • Data Source
      KAKENHI-PROJECT-19390061

  • [Presentation] ヒスタミンH3受容体に結合し発現量を制御するタンパク質の新たな同定2009
    • Author(s)
      高柳詩織、木下和樹、佐藤岳哉、前田恵、原口満也、谷内一彦、福永浩司、柳澤輝行、助川淳
    • Organizer
      第82回日本薬理学会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-19390061

  • [Presentation] 高速液体クロマトグラフィーを用いた簡便なヒスタミンと1-メチルヒスタミンの同時定量2009
    • Author(s)
      井筒敏恵, 櫻井映子, 及川綾子, 瀧野奈緒子, 谷内一彦
    • Organizer
      第82回日本薬理学会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-19390061

  • [Presentation] 2-フロロピリジン誘導体化による代謝安定性の向上を目指した^<18>F標識MMP-2画像化プローブの開発2009
    • Author(s)
      古本祥三, 酒井英太, 石川洋一, 谷内一彦, 福田寛, 岩田錬
    • Organizer
      第49回日本核医学会学術総会
    • Place of Presentation
      旭川
    • Year and Date
      2009-10-01
    • Data Source
      KAKENHI-PROJECT-19390311

  • [Presentation] 規制薬物誘発の異常行動とヒスタミン神経2009
    • Author(s)
      瀧野奈緒子, 櫻井映子, 岩村樹憲, 谷内一彦
    • Organizer
      第82回日本薬理学会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-19390061

  • [Presentation] 抗ヒスタミン薬の最新科学 : インペアード・パフォーマンスを中心に2009
    • Author(s)
      谷内一彦
    • Organizer
      第82回日本薬理学会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-19390061

  • [Presentation] ヒスタミンH3受容体の細胞表面発現に対する細胞内クロライドチャネルの影響2008
    • Author(s)
      原口満也, 前田恵, 倉増敦朗, 佐藤岳哉, 谷内一彦, 福永浩司, 柳澤輝行, 助川淳
    • Organizer
      第81回日本薬理学会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-19390061

  • [Presentation] 中枢ヒスタミン受容体の規制薬物誘発行動異常への関与2008
    • Author(s)
      瀧野奈緒子, 櫻井映子, 奥田友宏, 岩村樹憲, 谷内一彦
    • Organizer
      第38回日本精神神経薬理学会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-19390061

  • [Presentation] フッ素18標識アミロイドイメージング剤の開発2008
    • Author(s)
      古本祥三、岡村信行、加藤元久、石川洋一、丸山将浩、岩田錬、谷内一彦、樋口真人、須原哲也、工藤幸司
    • Organizer
      第48回日本核医学会総会
    • Place of Presentation
      千葉市幕張
    • Year and Date
      2008-10-25
    • Data Source
      KAKENHI-PROJECT-19390311

  • [Presentation] Effects of methamphetamine on locomotor sensitization and conditioned place preference in histamine receptor deficient mice2008
    • Author(s)
      Takino N, Sakurai E, Iwamura T, Yanai K
    • Organizer
      XI Workshop on apoptosis in biology and medicine
    • Place of Presentation
      仙台
    • Data Source
      KAKENHI-PROJECT-19390061

  • [Presentation] Sedation and impaired performance by antihistamines: PET measurements of H1 receptor occupancy2008
    • Author(s)
      K. Yanai
    • Organizer
      International Investigative Dermatology 2008
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-19390061

  • [Presentation] アルツハイマー病の分子イメージング研究2008
    • Author(s)
      谷内一彦
    • Organizer
      第81回日本薬学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2008-03-17
    • Data Source
      KAKENHI-PROJECT-18613001

  • [Presentation] Molecular PET imaging of acetylcholine esterase, histamine H1 receptor and amyloid deposits in Alzheimer disease2008
    • Author(s)
      Okamura N, Yanai K
    • Organizer
      13th International Conference on Biomedical Engineering(ICBME2008)
    • Place of Presentation
      シンガポール
    • Data Source
      KAKENHI-PROJECT-19390061

  • [Presentation] 低分子量G蛋白質RacはヒスタミンH4受容体C末端に結合する2008
    • Author(s)
      若林深恵, 倉増敦朗, 谷内一彦
    • Organizer
      第81回日本薬理学会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-19390061

  • [Presentation] ヒスタミンH3受容体カルボキシ末端はGi蛋白質を介するシグナリングに必要である2008
    • Author(s)
      倉増敦朗、助川淳、佐藤岳哉、櫻井映子、渡邉建彦、柳澤輝行、谷内一彦
    • Organizer
      第81回日本薬理学会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-19390061

  • [Presentation] フッ素18標識アミロイドイメージング剤の開発2008