Yoshimoto Keiko 吉本桂子

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YOSHIMOTO Keiko 吉本桂子

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Researcher Number	20383292
Other IDs
Affiliation (Current)	2025: 慶應義塾大学, 医学部(信濃町), 研究員
Affiliation (based on the past Project Information) *help	2018 – 2023: 慶應義塾大学, 医学部(信濃町), 研究員 2017: 慶應義塾大学, 医学部, 研究員 2016: 慶應義塾大学, 医学部(信濃町), 研究員 2010 – 2015: 慶應義塾大学, 医学部, 研究員 2006 – 2007: 埼玉医科大学, 医学部, 研究員
Review Section/Research Field	Principal Investigator Basic Section 54020:Connective tissue disease and allergy-related / Collagenous pathology/Allergology / 膠原病・アレルギー・感染症内科学 Except Principal Investigator Basic Section 54020:Connective tissue disease and allergy-related / 膠原病・アレルギー・感染症内科学
Keywords	Principal Investigator BAFF / B細胞 / BAFF受容体 / 単球 / シェーグレン症候群 / IL-6 / イオンチャンネル / IgG / 膠原病学 / 低分子化合物 … More / B細胞分化 / 全身性エリテマトーデス / 自己免疫疾患 / B細胞活性化因子（BAFF） / 自己抗体 / シェーグレン症候群ｎ / 医薬品リポジショニング / シグナル伝達経路 / リン酸化 / 阻害剤 / JAK3 / シグナル伝達 / 細胞シグナル伝達 / サイトカイン … More Except Principal Investigator CD103 / 単球 / インテグリン / カドヘリン / 上皮障害 / 自己免疫 / TLR / 組織傷害 / BAFF受容体 / Toll様受容体 / シェーグレン症候群 / フローサイトメトリー / ノックアウトマウス / 末梢血 / MS4A4A / 関節リウマチ / integrin / adherin / epithelial injuries / autoimmunity / CDIO3 / シグナル伝達 Less

B細胞機能制御作用を有する低分子化合物を用いたSLE新規治療標的分子の探索Principal Investigator
- Principal Investigator
  
  吉本桂子
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54020:Connective tissue disease and allergy-related
- Research Institution
  Keio University
Elucidation of the regulatory mechanisms of the crosstalk between BAFF signaling and Nav channel in monocytes aiming at development of radical therapy for Sjögrens syndrome.Principal Investigator
- Principal Investigator
  
  Yoshimoto Keiko
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54020:Connective tissue disease and allergy-related
- Research Institution
  Keio University
Elucidation of molecular mechanisms of monocyte activation through TLR signaling in Sjögrens syndrome.
- Principal Investigator
  
  Ikeda Yumi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54020:Connective tissue disease and allergy-related
- Research Institution
  Keio University
Function and clinical application of MS4A4A involved in pathology of rheumatoid arthritis
- Principal Investigator
  
  Yamaoka Kunihiro
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54020:Connective tissue disease and allergy-related
- Research Institution
  Kitasato University
Exploration of therapeutic targets which are involved in the pathogenesis of Sjogren's syndrome aiming at ion channels.Principal Investigator
- Principal Investigator
  
  Yoshimoto Keiko
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Collagenous pathology/Allergology
- Research Institution
  Keio University
Discovery of therapeutic targets for Sjogren's syndromePrincipal Investigator
- Principal Investigator
  
  Yoshimoto Keiko
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Collagenous pathology/Allergology
- Research Institution
  Keio University
Search for BAFF signaling inhibitors as novel drugs for the treatment of Sjogren's syndrome.Principal Investigator
- Principal Investigator
  
  YOSHIMOTO Keiko
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  Keio University
Analysis on signal transduction pathway through CD103 molecule
- Principal Investigator
  
  TAKEUCHI Tsutomu
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  Saitama Medical University
Molecular mechanism and its regulation of heterophilic adhesion between α E 3 7 (CD103) and E-cadherin in autoimmune epithelial injury
- Principal Investigator
  
  TAKEUCHI Tsutomu
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  Saitama Medical University

[Journal Article] Effects of interleukin-6 signal inhibition on Treg subpopulations and association of Tregs with clinical outcomes in rheumatoid arthritis2024
- Author(s)
  Yoshida Hiroto、Magi Mayu、Tamai Hiroya、Kikuchi Jun、Yoshimoto Keiko、Otomo Kotaro、Matsumoto Yoshihiro、Noguchi-Sasaki Mariko、Takeuchi Tsutomu、Kaneko Yuko
- Journal Title
  
  Rheumatology
  
  Volume: 00 Issue: 9 Pages: 1-10
- DOI
  10.1093/rheumatology/keae196
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08527
[Journal Article] Cytotoxic Tph subset with low B-cell helper functions and its involvement in systemic lupus erythematosus2024
- Author(s)
  Seki Noriyasu、Tsujimoto Hideto、Tanemura Shuhei、Kojima Shinji、Miyoshi Fumihiko、Kikuchi Jun、Saito Shuntaro、Akiyama Mitsuhiro、Sugahara Kunio、Yoshimoto Keiko、Kaneko Yuko、Chiba Kenji、Takeuchi Tsutomu
- Journal Title
  
  Communications Biology
  
  Volume: 7 Issue: 1 Pages: 2771-12
- DOI
  10.1038/s42003-024-05989-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08527
[Journal Article] Sodium benzoate attenuates 2,8-dihydroxyadenine nephropathy by inhibiting monocyte/macrophage TNF-α expression2023
- Author(s)
  Yoichi Oshima, Shu Wakino, Takeshi Kanda, Takaya Tajima, Tomoaki Itoh, Kiyotaka Uchiyama, Keiko Yoshimoto, Jumpei Sasabe, Masato Yasui, Hiroshi Itoh
- Journal Title
  
  Sci Rep
  
  Volume: 13 Issue: 1 Pages: 3331-3331
- DOI
  10.1038/s41598-023-30056-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08527, KAKENHI-PROJECT-21K18270, KAKENHI-PROJECT-20H00535
[Journal Article] Significant association of CX3CR1+CD8 T cells with aging and distinct clinical features in Sj?gren's syndrome and IgG4-related disease2023
- Author(s)
  Akiyama Mitsuhiro、Yoshimoto Keiko、Kaneko Yuko
- Journal Title
  
  Clinical and Experimental Rheumatology
  
  Volume: 41(12) Pages: 2409-2417
- DOI
  10.55563/clinexprheumatol/kfsd65
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K08527, KAKENHI-PROJECT-21K16292
[Journal Article] Distinct gene signatures of monocytes and B cells in patients with giant cell arteritis: a longitudinal transcriptome analysis2023
- Author(s)
  Kotaro Matsumoto, Katsuya Suzuki, Hiroto Yoshida, Mayu Magi, Yoshihiro Matsumoto, Mariko Noguchi-Sasaki, Keiko Yoshimoto, Tsutomu Takeuchi, Yuko Kaneko
- Journal Title
  
  Arthritis Res Ther.
  
  Volume: 25 Issue: 1 Pages: 1-1
- DOI
  10.1186/s13075-022-02982-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08527, KAKENHI-PROJECT-20H03720, KAKENHI-PROJECT-21K16306
[Journal Article] T follicular helper cells and T peripheral helper cells in rheumatic and musculoskeletal diseases2023
- Author(s)
  Akiyama Mitsuhiro、Alshehri Waleed、Yoshimoto Keiko、Kaneko Yuko
- Journal Title
  
  Annals of the Rheumatic Diseases
  
  Volume: 82 Issue: 11 Pages: 1371-1381
- DOI
  10.1136/ard-2023-224225
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K08527, KAKENHI-PROJECT-21K16292
[Journal Article] Anti-human-TIGIT agonistic antibody ameliorates autoimmune diseases by inhibiting Tfh and Tph cells and enhancing Treg cells2023
- Author(s)
  Kojima Marenori、Suzuki Katsuya、Takeshita Masaru、Ohyagi Masaki、Iizuka Mana、Yamane Humitsugu、Koga Keiko、Kouro Taku、Kassai Yoshiaki、Yoshihara Tomoki、Adachi Ryutaro、Hashikami Kentarou、Ota Yuichiro、Yoshimoto Keiko、Kaneko Yuko、Morita Rimpei、Yoshimura Akihiko、Takeuchi Tsutomu
- Journal Title
  
  Communications Biology
  
  Volume: 6 Issue: 1 Pages: 500-500
- DOI
  10.1038/s42003-023-04874-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07140, KAKENHI-PROJECT-22K08527
[Journal Article] Clinical and immunological effects of hydroxychloroquine in patients with active rheumatoid arthritis despite antirheumatic treatment2022
- Author(s)
  Takei H, Takanashi S, Otomo K, Hanaoka H, Kikuchi J, Yamaoka K, Yoshimoto K, Abe T, Takeuchi T, Kaneko Y.
- Journal Title
  
  Mod Rheumatol.
  
  Volume: - Issue: 1 Pages: 50-59
- DOI
  10.1093/mr/roac153
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K16350, KAKENHI-PROJECT-22K08527, KAKENHI-PROJECT-21K08446, KAKENHI-PROJECT-21K18227
[Journal Article] Distinct impact of malignancy and allergy on the clinical and immunological features of IgG4-related disease2022
- Author(s)
  Takanashi Satoshi、Akiyama Mitsuhiro、Furuhashi Kazunori、Yoshimoto Keiko、Tanemura Shuhei、Seki Noriyasu、Tsujimoto Hideto、Chiba Kenji、Kaneko Yuko
- Journal Title
  
  Clinical and Experimental Rheumatology
  
  Volume: - Pages: 1754-1761
- DOI
  10.55563/clinexprheumatol/7g2na0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K16292, KAKENHI-PROJECT-22K08527
[Journal Article] Role of interferons (IFNs) in the differentiation of T peripheral helper (Tph) cells: : 2. IFN-α and IFN-λ1 cooperatively contribute to the expansion of Tph cells in systemic lupus erythematosus2022
- Author(s)
  Shuhei Tanemura, Noriyasu Seki, Hideto Tsujimoto, Shuntaro Saito, Jun Kikuchi, Kunio Sugahara, Keiko Yoshimoto, Katsuya Suzuki, Yuko Kaneko, Kenji Chiba, Tsutomu Takeuchi
- Journal Title
  
  Int Immunol
  
  Volume: 34(10) Issue: 10 Pages: 533-544
- DOI
  10.1093/intimm/dxac032
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08527
[Journal Article] Differences in the strength of inhibition of interleukin-6 signalling by subcutaneous sarilumab and tocilizumab in rheumatoid arthritis patients2022
- Author(s)
  Saito Shuntaro、Suzuki Katsuya、Yoshimoto Keiko、Kondo Yasushi、Kikuchi Jun、Hanaoka Hironari、Kaneko Yuko、Takeuchi Tsutomu
- Journal Title
  
  Clinical and Experimental Rheumatology
  
  Volume: ー Pages: 1451-1455
- DOI
  10.55563/clinexprheumatol/k0ctlf
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03720, KAKENHI-PROJECT-22K08527
[Journal Article] Role of interferons (IFNs) in the differentiation of T peripheral helper (Tph) cells: : 1. Type I IFNs promote the differentiation of interleukin-21-producing Tph-like cells2022
- Author(s)
  Shuhei Tanemura, Hideto Tsujimoto, Noriyasu Seki, Shinji Kojima, Fumihiko Miyoshi, Kunio Sugahara, Keiko Yoshimoto, Katsuya Suzuki, Yuko Kaneko, Kenji Chiba, Tsutomu Takeuchi
- Journal Title
  
  Int Immunol
  
  Volume: 34(10) Issue: 10 Pages: 519-532
- DOI
  10.1093/intimm/dxac026
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08527, KAKENHI-PROJECT-20H03720
[Journal Article] Platelet CXCL4 mediates neutrophil extracellular traps formation in ANCA-associated vasculitis2021
- Author(s)
  Matsumoto Kotaro、Yasuoka Hidekata、Yoshimoto Keiko、Suzuki Katsuya、Takeuchi Tsutomu
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Issue: 1
- DOI
  10.1038/s41598-020-80685-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08890, KAKENHI-PROJECT-20K22911
[Journal Article] Peripheral TIGIT+ T Follicular Helper Cells That Produce High Levels of Interleukin-21 via OX40 Represent Disease Activity in IgG4-Related Disease2021
- Author(s)
  Akiyama Mitsuhiro、Suzuki Katsuya、Yoshimoto Keiko、Yasuoka Hidekata、Kaneko Yuko、Takeuchi Tsutomu
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 12 Pages: 651357-651357
- DOI
  10.3389/fimmu.2021.651357
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08890
[Journal Article] Identification of neutrophil β2-integrin LFA- 1 as a potential mechanistic biomarker in ANCA-associated vasculitis via microarray and validation analyses2021
- Author(s)
  Matsumoto K, Kurasawa T, Yoshimoto K, Suzuki K, Takeuchi T
- Journal Title
  
  Arthritis Research & Therapy
  
  Volume: 23 Issue: 1 Pages: 136-136
- DOI
  10.1186/s13075-021-02510-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K22911, KAKENHI-PROJECT-19K08890
[Journal Article] Interleukin‐1 pathway in active large vessel vasculitis patients with a poor prognosis: a longitudinal transcriptome analysis2021
- Author(s)
  Matsumoto Kotaro、Suzuki Katsuya、Yoshimoto Keiko、Ishigaki Sho、Yoshida Hiroto、Magi Mayu、Matsumoto Yoshihiro、Kaneko Yuko、Takeuchi Tsutomu
- Journal Title
  
  Clinical and Translational Immunology
  
  Volume: 10 Issue: 7
- DOI
  10.1002/cti2.1307
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08890, KAKENHI-PROJECT-21K16306
[Journal Article] Tocilizumab monotherapy uncovered the role of the CCL22/17-CCR4+ Treg axis during remission of crescentic glomerulonephritis2020
- Author(s)
  Sakai R, Ito M, Yoshimoto K, Chikuma S, Kurasawa T, Kondo T, Suzuki K, Takeuchi T, Amano K, Yoshimura A
- Journal Title
  
  Clin Transl Immunology
  
  Volume: 9 Issue: 11
- DOI
  10.1002/cti2.1203
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07488, KAKENHI-PROJECT-19K08890, KAKENHI-PUBLICLY-19H04816, KAKENHI-PUBLICLY-19H04817, KAKENHI-PUBLICLY-19H05431, KAKENHI-PROJECT-17H06175, KAKENHI-PROJECT-20K20384, KAKENHI-PROJECT-19K16618
[Journal Article] Aryl hydrocarbon receptor signals attenuate lung fibrosis in the bleomycin-induced mouse model for pulmonary fibrosis through increase of regulatory T cells2020
- Author(s)
  Takei Hiroshi、Yasuoka Hidekata、Yoshimoto Keiko、Takeuchi Tsutomu
- Journal Title
  
  Arthritis Research & Therapy
  
  Volume: 22 Issue: 1 Pages: 20-20
- DOI
  10.1186/s13075-020-2112-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08890, KAKENHI-PROJECT-19K17893
[Journal Article] Elevated expression of BAFF receptor, BR3, on monocytes correlates with B cell activation and clinical features of patients with primary Sjogren’s syndrome2020
- Author(s)
  Yoshimoto Keiko、Suzuki Katsuya、Takei Eriko、Ikeda Yumi、Takeuchi Tsutomu
- Journal Title
  
  Arthritis Research & Therapy
  
  Volume: 22 Issue: 1
- DOI
  10.1186/s13075-020-02249-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08890, KAKENHI-PROJECT-19K08919, KAKENHI-PROJECT-19K17916
[Journal Article] Longitudinal immune cell monitoring identified CD14++ CD16+ intermediate monocyte as a marker of relapse in patients with ANCA-associated vasculitis2020
- Author(s)
  Matsumoto Kotaro、Suzuki Katsuya、Yoshimoto Keiko、Seki Noriyasu、Tsujimoto Hideto、Chiba Kenji、Takeuchi Tsutomu
- Journal Title
  
  Arthritis Research & Therapy
  
  Volume: 22 Issue: 1
- DOI
  10.1186/s13075-020-02234-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08890
[Journal Article] Significant association between clinical characteristics and changes in peripheral immuno-phenotype in large vessel vasculitis2019
- Author(s)
  Matsumoto Kotaro、Suzuki Katsuya、Yoshimoto Keiko、Seki Noriyasu、Tsujimoto Hideto、Chiba Kenji、Takeuchi Tsutomu
- Journal Title
  
  Arthritis Research & Therapy
  
  Volume: 21 Issue: 1 Pages: 304-304
- DOI
  10.1186/s13075-019-2068-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08890
[Journal Article] Significant association between clinical characteristics and immuno-phenotypes in patients with ANCA-associated vasculitis2019
- Author(s)
  Matsumoto Kotaro、Suzuki Katsuya、Yoshimoto Keiko、Seki Noriyasu、Tsujimoto Hideto、Chiba Kenji、Takeuchi Tsutomu
- Journal Title
  
  Rheumatology
  
  Volume: 59 Pages: 545-553
- DOI
  10.1093/rheumatology/kez327
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08890
[Journal Article] Restoration of Decreased T Helper 1 and CD8+ T Cell Subsets Is Associated With Regression of Lymphoproliferative Disorders Developed During Methotrexate Treatment2018
- Author(s)
  Saito Shuntaro、Suzuki Katsuya、Yoshimoto Keiko、Kaneko Yuko、Yamaoka Kunihiro、Shimizu Takayuki、Mori Takehiko、Okamoto Shinichiro、Kameyama Kaori、Amano Koichi、Tamaru Jun-ichi、Tokuhira Michihide、Takeuchi Tsutomu
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 9 Pages: 621-621
- DOI
  10.3389/fimmu.2018.00621
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09905
[Journal Article] 2)Interleukin-4 contributes to the shift of balance of IgG subclasses toward IgG4 in IgG4-related disease.2018
- Author(s)
  Akiyama M, Yasuoka H, Yoshimoto K, Takeuchi T.
- Journal Title
  
  Cytokine
  
  Volume: 110 Pages: 416-419
- DOI
  10.1016/j.cyto.2018.05.009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09905
[Journal Article] Increased proportion of a CD38highIgD+ B cell subset in peripheral blood is associated with clinical and immunological features in patients with primary Sjögren's syndrome.2018
- Author(s)
  Ishioka-Takei E, Yoshimoto K, Suzuki K, Nishikawa A, Yasuoka H, Yamaoka K, Takeuti T.
- Journal Title
  
  Clinical Immnunology
  
  Volume: 187 Pages: 85-91
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09905
[Journal Article] Multi-omics monitoring of drug response in rheumatoid arthritis in pursuit of molecular remission.2018
- Author(s)
  Tasaki S, Suzuki K, Kassai Y, Takeshita M, Murota A, Kondo Y, Ando T, Nakayama Y, Okuzono Y, Takiguchi M, Kurisu R, Miyazaki T, Yoshimoto K, Yasuoka H, Yamaoka K, Morita R, Yoshimura A, Toyoshiba H, Takeuchi T.
- Journal Title
  
  Nat Commun
  
  Volume: 9(1) Issue: 1 Pages: 2755-2755
- DOI
  10.1038/s41467-018-05044-4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09905, KAKENHI-PROJECT-16H05178
[Journal Article] CC-chemokine ligand 18 is a useful biomarker associated with disease activity in IgG4-related disease.2017
- Author(s)
  Akiyama M, Yasuoka H, Yoshimoto K, Takeuchi T.
- Journal Title
  
  Ann Rheum Dis
  
  Volume: - Issue: 9 Pages: 1386-1387
- DOI
  10.1136/annrheumdis-2017-212110
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09905
[Journal Article] シェーグレン症候群の病態におけるBAFF/BAFF受容体の役割と治療への展開2017
- Author(s)
  吉本桂子　竹内　勤
- Journal Title
  
  臨床免疫・アレルギー科
  
  Volume: 67 Pages: 377-382
- Data Source
  KAKENHI-PROJECT-16K09905
[Journal Article] CD14brightCD16+ intermedicate monocytes are induced by interleukin-10 and positively correlated with disease activity in rheumatoid arthritis.2017
- Author(s)
  Tsukamoto M, Seta N, Yoshimoto K, Suzuki K, Yamaoka K, Takeuchi T
- Journal Title
  
  Arthritis Res Ther
  
  Volume: 19 Issue: 1 Pages: 28-28
- DOI
  10.1186/s13075-016-1216-6
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16K09905, KAKENHI-PROJECT-16K19610
[Journal Article] Multiomic disease signatures converge to cytotoxic CD8 T cells in primary Sjögren's syndrome.2017
- Author(s)
  Tasaki S1,2, Suzuki K3, Nishikawa A3, Kassai Y4, Takiguchi M4, Kurisu R4, Okuzono Y4, Miyazaki T4,5, Takeshita M3, Yoshimoto K3, Yasuoka H3, Yamaoka K3, Ikeura K6, Tsunoda K6, Morita R7, Yoshimura A7, Toyoshiba H1, Takeuchi T3.
- Journal Title
  
  Ann Rheum Dis
  
  Volume: 76 Issue: 8 Pages: 1458-1466
- DOI
  10.1136/annrheumdis-2016-210788
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09905, KAKENHI-PROJECT-17K11853, KAKENHI-PROJECT-16H05178
[Journal Article] Identification of definitive serum biomarkers associated with disease activity in primary Sjogren's syndrome.2016
- Author(s)
  Nishikawa A, Suzuki K, Kassai Y, Gotou Y, Takiguchi M, Miyazaki T, Yoshimoto K, Yasuoka H, Yamaoka K, Morita R, Yoshimura A, Takeuchi T.
- Journal Title
  
  Arthritis Res Ther.
  
  Volume: 18 Issue: 1 Pages: 106-106
- DOI
  10.1186/s13075-016-1006-1
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16H05178, KAKENHI-PROJECT-16K09905
[Journal Article] Fcg receptor 3B polymorphism is associated with hypersensitivity reactions to adalimumab in Japanese patients with rheumatoid arthritis.2016
- Author(s)
  Tsukamoto M, Kameda H, Ohshige T, Kaneko Y, Yoshimoto K, Suzuki K, Takeuchi T
- Journal Title
  
  Mod Rheumatol.
  
  Volume: 18 Pages: 1-4
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16K09905
[Journal Article] Early Prognostic Factors Associated with the Efficacy of Infliximab Treatment for Patients with Rheumatoid Arthritis with Inadequate Response to Methotrexate.2016
- Author(s)
  Hayashi S, Suzuki K, Yoshimoto K, Takeshita M, Kurasawa T, Yamaoka K, Takeuchi T
- Journal Title
  
  Rheumatol Ther.
  
  Volume: 3 Pages: 155-166
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16K09905
[Journal Article] Bendamustine increases interleukin-10 secretion from B cells via p38 MAP kinase activation.2016
- Author(s)
  Lu L, Yoshimoto K, Morita A, Kameda H, Takeuchi T
- Journal Title
  
  Int Immunopharmacol.
  
  Volume: 39 Pages: 273-279
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09905
[Journal Article] Infliximab and etanercept have distinct actions but similar effects on cytokine profiles in rheumatoid arthritis.2015
- Author(s)
  Takeshita M, Suzuki K, Kikuchi J, Izumi K, Kurasawa T, Yoshimoto K, Amano K, Takeuchi T.
- Journal Title
  
  Cytokine
  
  Volume: 75(2) Issue: 2 Pages: 222-227
- DOI
  10.1016/j.cyto.2015.04.011
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25461483
[Journal Article] シェーグレン症候群～病態形成機序解明の試み～2015
- Author(s)
  吉本桂子
- Journal Title
  
  Allergology & Immunology
  
  Volume: Vol.22 No.12 Pages: 70-77
- Open Access
- Data Source
  KAKENHI-PROJECT-25461483
[Journal Article] Involvement of αEβ7 (CD103) in the pathogenesis of autoimmune diseases.2014
- Author(s)
  Yoshimoto K, Kurasawa T, Suzuki K, Takeuchi T.
- Journal Title
  
  Nihon Rinsho Meneki Gakkai Kaishi.
  
  Volume: 37(3) Pages: 171-175
- NAID
  130004875930
- Open Access
- Data Source
  KAKENHI-PROJECT-25461483
[Journal Article] Baseline levels of soluble interleukin-62014
- Author(s)
  Naoshi Nishina, Jun Kikuchi, Misato Hashizume, Keiko Yoshimoto, Hideto Kameda, Tsutomu Takeuchi
- Journal Title
  
  Ann Rheum Dis
  
  Volume: 73(5) Issue: 5 Pages: 945-7
- DOI
  10.1136/annrheumdis-2013-204137
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25461483
[Journal Article] CD3 ζ defects in systemic lupus erythematosus2012
- Author(s)
  Takeuchi T
- Journal Title
  
  Ann Rheum Dis (Suppl)
  
  Volume: 71 Pages: i78-i81
- DOI
  10.1136/annrheumdis-2011-200641
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591268, KAKENHI-PROJECT-22591084
[Journal Article] 自己免疫疾患の病態形成におけるmTORの関与について2011
- Author(s)
  吉本桂子
- Journal Title
  
  月刊リウマチ科
  
  Volume: 46(1) Pages: 67-71
- URL
  http://www.kahyo.com/item/R201107-461
- Data Source
  KAKENHI-PROJECT-22591084
[Journal Article] Regulatory mechanisms for the production of BAFF and IL-6 are impaired in monocytes of patients of primary Sjogren's syndrome2011
- Author(s)
  Keiko Yoshimoto, et al
- Journal Title
  
  Arthritis Research and Therapy
  
  Volume: 13(5)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591084
[Journal Article] Regulatory mechanisms for the production of BAFF and IL-6 are impaired in monocytes of patients of primary Sjogren's syndrome2011
- Author(s)
  Yoshimoto K., Tanaka M., et al
- Journal Title
  
  Arthritis Research and Therapy
  
  Volume: 13(5) Issue: 5
- DOI
  10.1186/ar3493
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591084, KAKENHI-PROJECT-23592590
[Journal Article] IgG4-positive multi-organ lymphoproliferative syndrome manifesting as chronic symmetrical sclerosing dacryo-sialo-adenitis with subsequent secondary portal hypertension and remarkable IgG4-linked IL-4 elevation.2010
- Author(s)
  Suzuki K, Tamaru J, Okuyama A, Kameda H, Amano K, Nagasawa H, Nishi, E, Yoshimoto K, Setoyama Y, Kaneko K, Osada H, Honda N, Yasaki Y, Itoyama S, Tsuzaka K, Takeuchi T.
- Journal Title
  
  Rheumatology
  
  Volume: 49 Pages: 1789-1791
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591193
[Journal Article] Reduced expression of TCR zeta is involved in the abnormal production of cytokines by peripheral T cells of patients with systemic lupus erythematosus.2010
- Author(s)
  Yoshimoto K, Setoyama Y, Tsuzaka K, Abe T, Takeuchi T.
- Journal Title
  
  J Biomed Biotechnol
  
  Volume: Article ID 509021 Pages: 1-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591193
[Journal Article] IgG4-positive mufti-organ lymphoproliferative syndrome manife sting as chronic symmetrical sclerosing dacryo-sialo-adenitis with subsequent secondary portal hypertension and remarkable IgG4-linked IL-4 elevation.2010
- Author(s)
  Suzuki K, Tamaru J, Okuyama A, Kameda H, Amano K, Nagasawa H, Nishi, E, Yoshimoto K, Setoyama Y, Kaneko K, Osada H, Honda N, Yasaki Y, Itoyama S, Tsuzaka K, Takeuchi T.
- Journal Title
  
  Rheumatology (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591193
[Journal Article] The conservative sequences in 3'UTR of TCRζ mRNA regulate the production of TCRζ and TCR/CD3 complex in SLE T cells.2008
- Author(s)
  Tsuzaka K, Itami Y, Kumazawa C, Suzuki M, Setoyama Y, Yoshimoto K, Suzuki K, Abe T, Takeuchi T.
- Journal Title
  
  Biochemical Biophysical Research Communications 367
  
  Pages: 311-317
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591193
[Journal Article] Effect of Interleukin 2 on synthesis of B cell activating factor belonging to the tumor necrosis factor family (BAFF) in human peripheral blood mononuclear cells.2008
- Author(s)
  Suzuki K, Setoyama Y, Yoshimoto K, Tsuzaka K, Abe T, Takeuchi T.
- Journal Title
  
  Cytokine 44巻
  
  Pages: 44-48
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591193
[Journal Article] Effect of Interleukin 2 on synthesis of B cell activating factor belonging to the tumor necrosis factor family (BAFF)in human peripheral blood mononuclear cells.2008
- Author(s)
  Suzuki K, Setoyama Y, Yoshimoto K, Tsuzaka K, Abe T, Takeuchi T
- Journal Title
  
  Cytokine 44
  
  Pages: 44-48
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591193
[Journal Article] T The conservative sequences in 3' UTR of TCRtξ mRNA regulate the production of TCRξ and TCR/CD3 complex in SLE T cells.2008
- Author(s)
  Tsuzaka, K, Itami, Y, Kumazawa, C, Suzuki, M, Setoyama, Y, Yoshimoto, K, Suzuki, K, Abe, T, Takeuchi, T
- Journal Title
  
  BBRC 367
  
  Pages: 311-317
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591122
[Journal Article] The conservative sequences in 3'UTR of TCRζ mRNA regulate the production of TCRζ and TCR/CD3 complex in SLE T cells.2008
- Author(s)
  Tsuzaka K, Itami Y, Kumazawa C, Suzuki M, Setoyama Y, Yoshimoto K, Suzuki K, Abe T, Takeuchi T.
- Journal Title
  
  Biochemical Biophysical Research Communications 367巻
  
  Pages: 311-317
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591193
[Journal Article] DNA microarray gene expression profile of T cells with splice variants of TCRz mRNA observed in SLE2006
- Author(s)
  Tsuzaka, K, Nozaki, K, Kumazawa, C, Shiraishi, K, Setoyama, Y, Yoshimoto, K, Suzuki, K, Abe, T, Takeuchi, T
- Journal Title
  
  J Immunol 176
  
  Pages: 949-56
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591122
[Journal Article] TCRz mRNA splice variant forms observed in peripheral blood T cells from systemic lupus erythematosus patients2006
- Author(s)
  Tsuzaka, K, Nozaki, K, Kumazawa, C, Shiraishi, K, Setoyama, Y, Yoshimoto, K, Abe, T, Takeuchi, T
- Journal Title
  
  Springer Seminars in Immunopathology 28
  
  Pages: 185-93
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591122
[Journal Article] Aberrant expression of BAFF in T cells of systemic lupus erythematosus, which is recapitulated by a human T cell line, Loucy Int.2006
- Author(s)
  Yoshimoto Kerko
- Journal Title
  
  J. Immunology 18
  
  Pages: 1189-1196
- Data Source
  KAKENHI-PROJECT-18591122
[Journal Article] Aberrant expression of BAFF in T cells of systemic lupus erythematosus, which is recapitulated by a human T cell line, Loucy2006
- Author(s)
  Yoshimoto, K, Takahashi, Y, Ogasawara, M, Setoyama, Y, Suzuki, K, Tsuzaka, K, Abe, T, Takeuchi, T
- Journal Title
  
  Int Immunol 18
  
  Pages: 1189-96
- NAID
  10020618413
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591122
[Patent] ピロロピリミジン化合物を有効成分とする炎症性疾患の予防及び／又は治療2019
- Inventor(s)
  竹内　勤、鈴木勝也、吉本桂子
- Industrial Property Rights Holder
  竹内　勤、鈴木勝也、吉本桂子
- Industrial Property Rights Type
  特許
- Filing Date
  2019
- Overseas
- Data Source
  KAKENHI-PROJECT-19K08890
[Patent] ピロロピリミジン化合物を有効成分とする炎症性疾患の予防及び／又は治療剤2018
- Inventor(s)
  吉本桂子、鈴木勝也、竹内　勤
- Industrial Property Rights Holder
  吉本桂子、鈴木勝也、竹内　勤
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2018-092068
- Filing Date
  2018
- Data Source
  KAKENHI-PROJECT-16K09905
[Patent] 炎症性疾患の予防及び/又は治療剤2014
- Inventor(s)
  竹内勤　吉本桂子
- Industrial Property Rights Holder
  竹内勤　吉本桂子
- Industrial Property Rights Type
  特許
- Filing Date
  2014-10-07
- Overseas
- Data Source
  KAKENHI-PROJECT-25461483
[Presentation] Signaling pathways via TLR4 are involved in elevated expression of BAFF receptor, BR3, in peripheral monocytes of patients with primary Sjogren’s syndrome.2024
- Author(s)
  Keiko Yoshimoto, Yumi Ikeda, Katsuya Suzuki, Hiroyuki Fukui, Kotaro Matsumoto, Masaru Takeshita, Tsutomu Takeuchi, Yuko Kaneko
- Organizer
  The 52th Annual Meeting of Japanese Society for Immunology
- Data Source
  KAKENHI-PROJECT-22K08527
[Presentation] BAFFシグナル阻害作用を有する低分子化合物、BIK387のB細胞機能抑制機序の検討2023
- Author(s)
  吉本桂子、鈴木勝也、齋藤俊太郎、菊池　潤、竹内　勤、金子祐子
- Organizer
  第67回日本リウマチ学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-22K08527
[Presentation] Possible involvement of TLR4 in the pathogenesis of primary Sjogren’s syndrome through induction of the expression of BAFF receptor, BR3 in peripheral monocytes.2023
- Author(s)
  Keiko Yoshimoto, Yumi Ikeda, Katsuya Suzuki, Hiroyuki Fukui, Kotaro Matsumoto, Masaru Takeshita, Tsutomu Takeuchi, Yuko Kaneko
- Organizer
  ACR Convergence 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K08527
[Presentation] 末梢血CX3CR1+CD14++CD16+単球とフラクタルカインはSLE病勢に関与する2023
- Author(s)
  吉本桂子、鈴木勝也、関　則靖、平本和音、齋藤俊太郎、菊池　潤、花岡洋成、菅原邦夫、千葉健治、竹内　勤、金子祐子
- Organizer
  第67回日本リウマチ学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-22K08527
[Presentation] 原発性シェーグレン症候群患者末梢血単球でのTLR4を介したシグナルはBAFF受容体発現を誘導し病態に寄与する2023
- Author(s)
  吉本桂子、池田由美、鈴木勝也、福井裕之、松本紘太郎、竹下　勝、竹内　勤、金子祐子
- Organizer
  第31回日本シェーグレン症候群学会学術集会
- Data Source
  KAKENHI-PROJECT-22K08527
[Presentation] シェーグレン症候群患者末梢血単球でのBAFF受容体とNav1.7発現の関連性と細胞機能への寄与に関する検討2022
- Author(s)
  吉本桂子、鈴木勝也、池田由美、松本紘太郎、竹内　勤、金子祐子
- Organizer
  第30回日本シェーグレン症候群学会学術集会
- Data Source
  KAKENHI-PROJECT-22K08527
[Presentation] Reduced expression of CX3CR1 in CD14++CD16+ peripheral monocytes is associated with immunological and clinical features of patients with systemic lupus erythematosus.2022
- Author(s)
  Keiko Yoshimoto, Katsuya Suzuki, Yumi Ikeda, Noriyasu Seki, Kazuoto Hiramoto, Shuntaro Saito, Jun Kikuchi, Hironari Hanaoka, Kunio Sugahara, Kenji Chiba, Tsutomu Takeuchi, Yuko Kaneko
- Organizer
  第51回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-22K08527
[Presentation] 原発性シェーグレン症候群患者末梢血単球でのBAFF受容体発現亢進に寄与するTLR4シグナル経路の詳細解析2022
- Author(s)
  池田由美、吉本桂子、鈴木勝也、福井裕之、竹下　勝、松本紘太郎、竹内　勤、金子祐子
- Organizer
  第66回日本リウマチ学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-22K08527
[Presentation] BAFFシグナル阻害活性作用を有する低分子化合物の自己免疫疾患病態モデルでの経口投与によるB細胞活性化抑制作用の検証2022
- Author(s)
  吉本桂子、鈴木勝也、池田由美、齋藤俊太郎、菊池　潤、竹内　勤、金子祐子
- Organizer
  第66回日本リウマチ学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-22K08527
[Presentation] A novel pyrrolopyrimidine derivative that inhibits BAFF signaling suppresses B cell differentiation and production of autoantibody in autoimmune model mice by oral administration.2022
- Author(s)
  Keiko Yoshimoto, Katsuya Suzuki, Yumi Ikeda, Tsutomu Takeuchi, Yuko Kaneko
- Organizer
  American college of Rheumatology Annual Meeting 2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K08527
[Presentation] SLE患者末梢血CX3CR1陽性CD14++CD16+単球と腎病変との関連2022
- Author(s)
  吉本桂子、鈴木勝也、池田由美、関　則靖、平本和音、齋藤俊太郎、菊池　潤、花岡洋成、菅原邦夫、千葉健治、竹内　勤、金子祐子
- Organizer
  第66回日本リウマチ学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-22K08527
[Presentation] 原発性シェーグレン症候群患者末梢血単球でのBAFF受容体発現亢進にはTLR4シグナル経路が関与する2021
- Author(s)
  池田由美、吉本桂子、鈴木勝也、武井江梨子、竹内　勤
- Organizer
  第29回日本シェーグレン症候群学会学術集会
- Data Source
  KAKENHI-PROJECT-19K08919
[Presentation] Ⅰ型およびIII型インターフェロンはPD-1hi CXCR5- Tph細胞の誘導を促進する。2021
- Author(s)
  種村　修平、関　則靖，齋藤　俊太郎，菊池　潤，菅原　邦夫，吉本　桂子，鈴木　勝也，金子　祐子，千葉　健治，竹内　勤
- Organizer
  第65回日本リウマチ学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-19K08890
[Presentation] 全身エリテマトーデス病態モデルマウスにおけるT細胞機能異常に関する検討2021
- Author(s)
  田中祐樹、峯岸恵美、吉本桂子、池田由美、大友耕太郎、鈴木勝也、竹内　勤
- Organizer
  第65回日本リウマチ学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-19K08890
[Presentation] 原発性シェーグレン症候群患者末梢血単球でのBAFF受容体発現亢進にはTLR4シグナル経路が関与する2021
- Author(s)
  池田由美、吉本桂子、鈴木勝也、武井江梨子、竹内　勤
- Organizer
  第29回日本シェーグレン症候群学会学術集会
- Data Source
  KAKENHI-PROJECT-19K08890
[Presentation] 原発性シェーグレン症候群患者末梢血単球でのBAFF受容体発現亢進におけるTLR4シグナルの関与2021
- Author(s)
  池田由美、吉本桂子、鈴木勝也、武井江梨子、竹内　勤、金子　祐子
- Organizer
  第8回JCRベーシックリサーチカンファレンス
- Data Source
  KAKENHI-PROJECT-19K08890
[Presentation] 原発性シェーグレン症候群患者末梢血単球ではTLR4シグナル経路の活性化がBAFF受容体発現亢進に寄与する2021
- Author(s)
  池田由美、吉本桂子、鈴木勝也、武井江梨子、竹内　勤
- Organizer
  第65回日本リウマチ学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-19K08919
[Presentation] 原発性シェーグレン症候群患者末梢血単球におけるBAFFシグナルとイオンチャンネルのクロストーク機構の解析2021
- Author(s)
  吉本桂子、鈴木勝也、池田由美、武井江梨子、竹内　勤
- Organizer
  第65回日本リウマチ学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-19K08890
[Presentation] 原発性シェーグレン症候群患者末梢血単球におけるBAFFシグナルとイオンチャンネルのクロストーク機構の解析2021
- Author(s)
  吉本桂子、鈴木勝也、池田由美、武井江梨子、竹内　勤
- Organizer
  第65回日本リウマチ学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-19K08919
[Presentation] シェーグレン症候群末梢血単球でのBAFF誘導IL-6産生機構におけるNav1.7チャンネルの関与2021
- Author(s)
  吉本桂子、鈴木勝也、池田由美、武井江梨子、竹内　勤
- Organizer
  第29回日本シェーグレン症候群学会学術集会
- Data Source
  KAKENHI-PROJECT-19K08919
[Presentation] Possible involvement of the voltage-gated sodium channel 1.7 in activation of BAFF signaling in monocytes of patients with primary Sjogren’s syndrome.2021
- Author(s)
  Keiko Yoshimoto, Katsuya Suzuki, Yumi Ikeda, Eriko Takei, Tsutomu Takeuchi
- Organizer
  第50回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-19K08919
[Presentation] 病態モデルマウスを用いた全身性エリテマトーデスにおけるB細胞異常に関する解析2021
- Author(s)
  峯岸恵美、田中祐樹、吉本桂子、池田由美、大友耕太郎、鈴木勝也、竹内　勤
- Organizer
  第65回日本リウマチ学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-19K08919
[Presentation] SLEにおけるTph細胞とI型およびIII型インターフェロンの関連性2021
- Author(s)
  関　則靖、種村　修平，齋藤　俊太郎，菊池　潤，菅原　邦夫，吉本　桂子，鈴木　勝也，金子　祐子，千葉　健治，竹内　勤
- Organizer
  第65回日本リウマチ学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-19K08890
[Presentation] 病態モデルマウスを用いた全身性エリテマトーデスにおけるB細胞異常に関する解析2021
- Author(s)
  峯岸恵美、田中祐樹、吉本桂子、池田由美、大友耕太郎、鈴木勝也、竹内　勤
- Organizer
  第65回日本リウマチ学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-19K08890
[Presentation] 原発性シェーグレン症候群患者末梢血単球ではTLR4シグナル経路の活性化がBAFF受容体発現亢進に寄与する2021
- Author(s)
  池田由美、吉本桂子、鈴木勝也、武井江梨子、竹内　勤
- Organizer
  第65回日本リウマチ学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-19K08890
[Presentation] 全身エリテマトーデス病態モデルマウスにおけるT細胞機能異常に関する検討2021
- Author(s)
  田中祐樹、峯岸恵美、吉本桂子、池田由美、大友耕太郎、鈴木勝也、竹内　勤
- Organizer
  第65回日本リウマチ学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-19K08919
[Presentation] 原発性シェーグレン症候群患者末梢血単球でのBAFF受容体発現亢進におけるTLR4シグナルの関与2021
- Author(s)
  池田由美、吉本桂子、鈴木勝也、武井江梨子、竹内　勤、金子　祐子
- Organizer
  第8回JCRベーシックリサーチカンファレンス
- Data Source
  KAKENHI-PROJECT-19K08919
[Presentation] The proportion of interleukin-21 producing TIGIT+ T follicular helper cells represents disease activity in IgG4-related disease.2021
- Author(s)
  Mitsuhiro Akiyama, Katsuya Suzuki, Keiko Yoshimoto, Hidekata Yasuoka, Yuko Kaneko, Tsutomu Takeuchi
- Organizer
  第65回日本リウマチ学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-19K08890
[Presentation] Signaling pathways via Toll-like receptor 4 are involved in enhanced expression of BAFF receptor in CD14+CD16+ human monocytes.2021
- Author(s)
  Yumi Ikeda, Keiko Yoshimoto, Katsuya Suzuki, Eriko Takei, Tsutomu Takeuchi
- Organizer
  第50回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-19K08919
[Presentation] Activation of signaling pathways of Toll-like receptor 4 promotes expression of BAFF receptor, BR3 in CD14+CD16+ human monocytes.2021
- Author(s)
  Yumi Ikeda, Keiko Yoshimoto, Katsuya Suzuki, Eriko Takei, Tsutomu Takeuchi
- Organizer
  23rd APLAR Asia-Pasific League of Associations of Rheumatology Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08919
[Presentation] 関節リウマチ患者のトシリズマブ治療によるregulatory T細胞分画の挙動解析2021
- Author(s)
  吉田広人、間木麻友、玉井博也、菊池潤、吉本桂子、大友耕太郎、松本義弘、竹内勤
- Organizer
  第65回日本リウマチ学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-19K08890
[Presentation] Activation of signaling pathways of Toll-like receptor 4 promotes expression of BAFF receptor, BR3 in CD14+CD16+ human monocytes.2021
- Author(s)
  Yumi Ikeda, Keiko Yoshimoto, Katsuya Suzuki, Eriko Takei, Tsutomu Takeuchi
- Organizer
  23rd APLAR Asia-Pasific League of Associations of Rheumatology Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08890
[Presentation] シェーグレン症候群末梢血単球でのBAFF誘導IL-6産生機構におけるNav1.7チャンネルの関与2021
- Author(s)
  吉本桂子、鈴木勝也、池田由美、武井江梨子、竹内　勤
- Organizer
  第29回日本シェーグレン症候群学会学術集会
- Data Source
  KAKENHI-PROJECT-19K08890
[Presentation] BAFF-BAFF receptor, BR3, axis is involved in activation of monocytes via NF-kB pathways and assists B cell activation in patients with primary Sjogren’s syndrome.2021
- Author(s)
  Keiko Yoshimoto, Katsuya Suzuki, Yumi Ikeda, Eriko Takei, Tsutomu Takeuchi
- Organizer
  23rd APLAR Asia-Pasific League of Associations of Rheumatology Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08890
[Presentation] Signaling pathways via Toll-like receptor 4 are involved in enhanced expression of BAFF receptor in CD14+CD16+ human monocytes.2021
- Author(s)
  Yumi Ikeda, Keiko Yoshimoto, Katsuya Suzuki, Eriko Takei, Tsutomu Takeuchi
- Organizer
  第50回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-19K08890
[Presentation] BAFF-BAFF receptor, BR3, axis is involved in activation of monocytes via NF-kB pathways and assists B cell activation in patients with primary Sjogren’s syndrome.2021
- Author(s)
  Keiko Yoshimoto, Katsuya Suzuki, Yumi Ikeda, Eriko Takei, Tsutomu Takeuchi
- Organizer
  23rd APLAR Asia-Pasific League of Associations of Rheumatology Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08919
[Presentation] Possible involvement of the voltage-gated sodium channel 1.7 in activation of BAFF signaling in monocytes of patients with primary Sjogren’s syndrome.2021
- Author(s)
  Keiko Yoshimoto, Katsuya Suzuki, Yumi Ikeda, Eriko Takei, Tsutomu Takeuchi
- Organizer
  第50回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-19K08890
[Presentation] Signaling pathways via Toll-like receptor 4 are involved in elevated expression of BAFF receptor in monocytes.2020
- Author(s)
  Yumi Ikeda, Keiko Yoshimoto, Katsuya Suzuki, Eriko Takei, Tsutomu Takeuchi
- Organizer
  22nd Asia-Pacific League of Associations for Rheumatology Congress
- Data Source
  KAKENHI-PROJECT-19K08919
[Presentation] Signaling pathways via Toll-like receptor 4 are involved in elevated expression of BAFF receptor in monocytes.2020
- Author(s)
  Yumi Ikeda, Keiko Yoshimoto, Katsuya Suzuki, Eriko Takei, Tsutomu Takeuchi
- Organizer
  22nd Asia-Pacific League of Associations for Rheumatology Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08890
[Presentation] 原発性シェーグレン症候群患者末梢血単球でのBAFF受容体発現亢進はB細胞活性化および臨床的特徴に関与する2020
- Author(s)
  吉本桂子、鈴木勝也、武井江梨子、池田由美、竹内　勤
- Organizer
  第64回日本リウマチ学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-19K08919
[Presentation] A pyrrolopryimidine derivative, which targets BAFF binding to its receptor, BR3, suppresses B cell activation in vitro and in vivo.2020
- Author(s)
  Keiko Yoshimoto, Katsuya Suzuki, Noriyasu Seki, Kunio Sugahara, Kenji Chiba and Tsutomu Takeuchi
- Organizer
  22nd Asia-Pacific League of Associations for Rheumatology Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08890
[Presentation] 原発性シェーグレン症候群患者末梢血単球ではTLR4シグナル経路の活性化がBAFF受容体発現亢進に寄与する2020
- Author(s)
  池田由美、吉本桂子、鈴木勝也、武井江梨子、竹内　勤
- Organizer
  第64回日本リウマチ学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-19K08919
[Presentation] Possible involvement of Fractalkine/CX3CR1 axis in peripheral CD14++CD16+ monocytes in disease development of patients with systemic lupus erythematosus.2020
- Author(s)
  Keiko Yoshimoto, Katsuya Suzuki, Noriyasu Seki, Shuntaro Saito, Jun Kikuchi, Tsutomu Takeuchi
- Organizer
  American college of Rheumatology Annual Meeting 2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08890
[Presentation] 原発性シェーグレン症候群患者末梢血単球でのBAFF受容体発現亢進はB細胞活性化および臨床的特徴に関与する2020
- Author(s)
  吉本桂子、鈴木勝也、武井江梨子、池田由美、竹内　勤
- Organizer
  第64回日本リウマチ学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-19K08890
[Presentation] 原発性シェーグレン症候群患者末梢血単球ではTLR4シグナル経路の活性化がBAFF受容体発現亢進に寄与する2020
- Author(s)
  池田由美、吉本桂子、鈴木勝也、武井江梨子、竹内　勤
- Organizer
  第64回日本リウマチ学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-19K08890
[Presentation] 末梢血CD14++CD16+単球におけるフラクタルカイン-CX3CR1経路はSLE の病態と関連する2020
- Author(s)
  吉本桂子、鈴木勝也、関　則靖、齋藤俊太郎、菊池　潤、竹内　勤
- Organizer
  第64回日本リウマチ学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-19K08890
[Presentation] Innovative drug discovery for autoimmune diseases aiming at BAFF signaling pathway2019
- Author(s)
  Keiko Yoshimoto, Katsuya Suzuki, Noriyasu Seki, Kunio Sugahara, Kenji Chiba and Tsutomu Takeuchi
- Organizer
  Immunology 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08890
[Presentation] 活性型血小板は関節リウマチの活動性のバイオマーカーになる2019
- Author(s)
  安岡秀剛、坂田康明、吉本桂子、竹内　勤
- Organizer
  第5回日本骨免疫学会
- Data Source
  KAKENHI-PROJECT-19K08890
[Presentation] 原発性シェーグレン症候群患者末梢血単球でのBAFF受容体発現亢進とB細胞活性化の関与2019
- Author(s)
  吉本桂子、鈴木勝也、武井江梨子、竹内　勤
- Organizer
  第28回日本シェーグレン症候群学会・学術集会
- Data Source
  KAKENHI-PROJECT-19K08890
[Presentation] Elevated expression levels of the voltage-gated sodium channel 1.7 and BAFF receptor in peripheral monocytes contribute to activation of monocytes of patients with primary Sjögren’s syndrome.2019
- Author(s)
  Keiko Yoshimoto, Yumi Ikeda, Katsuya Suzuki and Tsutomu Takeuchi
- Organizer
  Immunology 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08919
[Presentation] ELEVATED EXPRESSION OF BAFF-RECEPTOR IN PERIPHERAL MONOCYTES PROMOTES B CELL ACTIVATION AND CORRELATES WITH CLINICAL MANIFESTATIONS OF PRIMARY SJÖGREN’S SYNDROME.2019
- Author(s)
  Keiko Yoshimoto, Katsuya Suzuki, Yumi Ikeda, Eriko Takei, Tsutomu Takeuchi
- Organizer
  EULAR 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08919
[Presentation] C57BL/6マウスにおけるコラーゲン誘発関節炎の発症プロトコルに関する検討2019
- Author(s)
  太田裕一朗、吉本桂子、山岡邦宏、竹内　勤
- Organizer
  第5回日本骨免疫学会
- Data Source
  KAKENHI-PROJECT-19K08890
[Presentation] Elevated expression levels of the voltage-gated sodium channel 1.7 and BAFF receptor in peripheral monocytes contribute to activation of monocytes of patients with primary Sjogren’s syndrome2019
- Author(s)
  Keiko Yoshimoto, Yumi Ikeda, Katsuya Suzuki and Tsutomu Takeuchi
- Organizer
  Immunology 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08890
[Presentation] SLE病態におけるCX3CR1陽性CD14++CD16+単球の関与2019
- Author(s)
  吉本桂子、鈴木勝也、齋藤俊太郎、菊池　潤、竹内　勤
- Organizer
  第63回日本リウマチ学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-19K08890
[Presentation] 関節リウマチ患者における生物学的製剤使用時の骨マーカー動態2019
- Author(s)
  玉井博也、仁科　直、太田裕一朗、菊池　潤、泉　啓介、金子祐子、吉本桂子、竹内　勤
- Organizer
  第5回日本骨免疫学会
- Data Source
  KAKENHI-PROJECT-19K08890
[Presentation] ＡＮＣＡ関連血管炎における血小板Toll様受容体シグナルを介したNETosis誘導の分子機構解明2019
- Author(s)
  松本紘太朗、安岡秀剛、吉本桂子、鈴木勝也、竹内　勤
- Organizer
  第5回日本骨免疫学会
- Data Source
  KAKENHI-PROJECT-19K08890
[Presentation] ELEVATED EXPRESSION OF BAFF-RECEPTOR IN PERIPHERAL MONOCYTES PROMOTES B CELL ACTIVATION AND CORRELATES WITH CLINICAL MANIFESTATIONS OF PRIMARY SJOGREN’S SYNDROME2019
- Author(s)
  Keiko Yoshimoto, Katsuya Suzuki, Yumi Ikeda, Eriko Takei, Tsutomu Takeuchi
- Organizer
  EULAR 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08890
[Presentation] BAFFシグナルを標的とした低分子化合物を用いたシェーグレン症候群治療薬創製への試み2018
- Author(s)
  吉本桂子、鈴木勝也、関　則靖、菅原邦夫、千葉健治、竹内　勤
- Organizer
  第27回日本シェーグレン症候群学会
- Invited
- Data Source
  KAKENHI-PROJECT-16K09905
[Presentation] 原発性シェーグレン症候群患者末梢血単球活性化におけるBAFFとMMP-9の関与2018
- Author(s)
  吉本桂子、鈴木勝也、竹内　勤
- Organizer
  第27回日本シェーグレン症候群学会
- Data Source
  KAKENHI-PROJECT-16K09905
[Presentation] 原発性シェーグレン症候群患者末梢血単球の活性化におけるBAFFとMMP9の関与2018
- Author(s)
  吉本桂子、鈴木勝也、竹内　勤
- Organizer
  第39回日本炎症・再生医学会
- Data Source
  KAKENHI-PROJECT-16K09905
[Presentation] Reduced expression of CX3CR1 in peripheral CD14++CD16+ monocytes is a novel feature of patients with systemic lupus erythematosus.2018
- Author(s)
  Keiko Yoshimoto, Katsuya Suzuki, Shuntaro Saito, Jun Kikuchi, Tsutomu Takeuchi
- Organizer
  ACR ARP 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09905
[Presentation] A Low molecular weight BAFF receptor antagonist inhibits differentiation of human peripheral B cells into plasma blasts/plasma cells in vitro.2018
- Author(s)
  Keiko Yoshimoto, Noriyasu Seki, Katsuya Suzuki, Kunio Sugahara, Tsutomu Takeuchi
- Organizer
  IMMUNOLOGY 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09905
[Presentation] Localization of the voltage-gated sodium channel 1.7 in peripheral monocytes contributes to activation of BAFF signaling in monocytes of patients with primary Sjogren’s syndrome.2018
- Author(s)
  Keiko Yoshimoto, Yumi Ikeda, Katsuya Suzuki, Tsutomu Takeuchi
- Organizer
  ACR ARP 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09905
[Presentation] Possible involvement of BAFF and matrixmetalloproteinase-9 in the activation of monocytes of patients with primary Sjogren’s syndrome.2018
- Author(s)
  Keiko Yoshimoto, Katsuya Suzuki, Tsutomu Takeuchi
- Organizer
  EULAR 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09905
[Presentation] A low molecular weight BAFF signaling inhibitor reduces production of autoantibody and suppresses infiltration of B cells into the organs in autoimmune model mice.2018
- Author(s)
  Keiko Yoshimoto, Katsuya Suzuki, Noriyasu Seki, Kunio Sugahara, Kenji Chiba, Tsutomu Takeuchi
- Organizer
  第47回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-16K09905
[Presentation] A low molecular weight BAFF signaling inhibitor, BIK-13, ameliorates B cell activation in vitro and in vivo autoimmune models and consequently suppresses production of IgG and cytokines2018
- Author(s)
  Keiko Yoshimoto, Noriyasu Seki, Katsuya Suzuki, Kunio Sugahara, Kenji Chiba, Tsutomu Takeuchi
- Organizer
  EULAR 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09905
[Presentation] Increased expression of BAFF receptor on monocytes is a contributory factor of IgG overproduction in patients with primary Sjögren's syndrome.2017
- Author(s)
  Keiko Yoshimoto, Katsuya Suzuki and Tsutomu Takeuchi
- Organizer
  Cytokines 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09905
[Presentation] B細胞活性化因子（BAFF）およびその受容体を標的とした自己免疫疾患治療薬創製の試み2017
- Author(s)
  吉本桂子、鈴木勝也、関　則靖、菅原邦夫、千葉健治、竹内　勤
- Organizer
  第45回日本臨床免疫学会
- Invited
- Data Source
  KAKENHI-PROJECT-16K09905
[Presentation] BAFF signaling inhibitors ameliorate enhanced production of IL-6 and IL-10 by pSS monocytes and consequently suppress IgG overproduction by affecting differentiation of B cells.2017
- Author(s)
  Keiko Yoshimoto, Noriyasu Seki, Katsuya Suzuki, Kunio Sugahara Tsutomu Takeuchi
- Organizer
  第46回日本免疫学会
- Data Source
  KAKENHI-PROJECT-16K09905
[Presentation] Low molecular weight BAFF signaling inhibitors ameliorate IL-6, IL-10 and IgG production in vitro and in vivo models of autoimmune diseases.2017
- Author(s)
  Keiko Yoshimoto, Katsuya Suzuki, Kunio Sugahara, Tsutomu Takeuchi
- Organizer
  EULAR 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09905
[Presentation] Inhibition of BAFF binding to its receptor, BR3, with low molecular weight compounds results in suppression of activation of monocytes and B cells in vitro and in vivo model of autoimmune diseases.2017
- Author(s)
  Keiko Yoshimoto, Katsuya Suzuki, Kunio Sugahara, Tsutomu Takeuchi
- Organizer
  1.Immunology 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09905
[Presentation] BAFF-BAFF受容体結合阻害作用を有する低分子化合物は形質芽細胞および形質細胞分化を抑制する2017
- Author(s)
  吉本桂子、関　則靖、鈴木勝也、菅原邦夫、竹内　勤
- Organizer
  第26回日本シェーグレン症候群学会
- Data Source
  KAKENHI-PROJECT-16K09905
[Presentation] Low molecular weight BAFF receptor antagonists restrain infiltration of B cells into organs of autoimmune model mice by suppressing B cell activation.2017
- Author(s)
  Keiko Yoshimoto, Noriyasu Seki, Katsuya Suzuki, Kunio Sugahara, Tsutomu Takeuchi
- Organizer
  ACR Annual Meeting 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09905
[Presentation] BAFF receptor antagonisits suppress differentiation of B cells in vitro and are frug candidates for primary Sjogren's syndrome.2016
- Author(s)
  Yoshimoto K, Seki N, Suzuki K, Sugahara K, Takeuchi T
- Organizer
  2016 ACR/ARHP Annual Meeting
- Place of Presentation
  Washington DC convention center　ワシントンDC(アメリカ）
- Year and Date
  2016-11-11
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09905
[Presentation] Low molecular weight-BAFF receptor antagomists are drug candidates for primary Sjogren's syndrome.2016
- Author(s)
  Yoshimoto K, Suzuki K, Sugahara K, Takeuchi T
- Organizer
  Biomarkers and Targeted Therapeutics in Sjogren's
- Place of Presentation
  Oklahoma City Convention Center オクラホマシティー（アメリカ）
- Year and Date
  2016-09-19
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09905
[Presentation] Low molecular weight compounds which inhibit BAFF binding to its receptor, BR3, suppress activation of monocytes.2016
- Author(s)
  Yoshimoto K, Ishioka E, Nishikawa A, Suzuki K, Ito T, Sugano T, Yamada H, Okuda A, Okuda H, Ishikawa H, Doi T, Hirokawa T, Takeuchi T
- Organizer
  IMMUNOLOGY 2016
- Place of Presentation
  Seattle Convention Center 　シアトル（アメリカ）
- Year and Date
  2016-05-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09905
[Presentation] Low molecular weight compound BAFF binding inhibitors suppress activation of monocytes through BAFF signaling involved in NF-kB pathways.2016
- Author(s)
  Yoshimoto K, Suzuki K, Sugahara K, Takeuchi T
- Organizer
  第45回日本免疫学会学術集会
- Place of Presentation
  沖縄コンベンションセンター　（沖縄県那覇市）
- Year and Date
  2016-12-05
- Data Source
  KAKENHI-PROJECT-16K09905
[Presentation] シェーグレン症候群治療薬としてのBAFF-BAFF受容体（BR3）結合阻害剤の検討2016
- Author(s)
  吉本桂子、石岡江梨子、西川あゆみ、鈴木勝也、菅原邦夫、竹内　勤
- Organizer
  第60回日本リウマチ学会総会・学術集会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-04-21
- Data Source
  KAKENHI-PROJECT-16K09905
[Presentation] Enhanced expression of BAFF receptor (BR3) on peripheral monocytes contributes production of IgG by B cells through IL-6 signaling in patients with primary Sjogren's syndrome.2016
- Author(s)
  Yoshimoto K, Ishioka E, Nishikawa A, Suzuki K, Takeuchi T
- Organizer
  International Congress of Immunology
- Place of Presentation
  Melbourne COnvention Center メルボルン（オーストラリア）
- Year and Date
  2016-08-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09905
[Presentation] CD103 overexpression induces abnormal activation of CD4+ T cells via BAFF signaling pathways2015
- Author(s)
  Keiko Yoshimoto
- Organizer
  第44回日本免疫学会総会・学術集会
- Place of Presentation
  札幌コンベンションセンター（北海道札幌市）
- Year and Date
  2015-11-18
- Data Source
  KAKENHI-PROJECT-25461483
[Presentation] シェーグレン症候群患者末梢血単球上のBAFF受容体（BR3）発現亢進による単球の機能異常が寄与するB細胞からのIgG産生促進機序の解明2015
- Author(s)
  吉本桂子
- Organizer
  第80回日本インターフェロンサイトカイン学会
- Place of Presentation
  東京工業大学（東京都目黒区）
- Year and Date
  2015-07-18
- Data Source
  KAKENHI-PROJECT-25461483
[Presentation] Pyrrolopyrimidine derivatives that inhibit BAFF binding to its receptor, BR3, decrease IgG production by B cells in vitro and in vivo model of autoimmune diseases2015
- Author(s)
  Keiko Yoshimoto
- Organizer
  ACR/ARHP Annual Meeting 2015
- Place of Presentation
  San Francisco, USA
- Year and Date
  2015-11-06
- Data Source
  KAKENHI-PROJECT-25461483
[Presentation] 単球とB細胞に焦点をあてたシェーグレン症候群根治療法開発への挑戦2015
- Author(s)
  吉本桂子
- Organizer
  第59回日本リウマチ学会総会・学術集会
- Place of Presentation
  名古屋国際会議場（愛知県名古屋市）
- Year and Date
  2015-04-23
- Data Source
  KAKENHI-PROJECT-25461483
[Presentation] BAFF-stimulated monocytes accelerates IgG production by B ｃｅｌｌｓ in patients with primary Sjogren's syndrome2015
- Author(s)
  Keiko Yoshimoto
- Organizer
  13th International Symposium on Sjogren's Syndrome
- Place of Presentation
  Bergen, Norway
- Year and Date
  2015-05-19
- Data Source
  KAKENHI-PROJECT-25461483
[Presentation] 一次性シェーグレン症候群（pSS）患者末梢血単球におけるBAFF受容体（BR3）発現亢進はIL-6を介してB細胞の機能異常を誘導する2015
- Author(s)
  吉本桂子
- Organizer
  第43回日本臨床免疫学会総会・学術集会
- Place of Presentation
  神戸国際会議場（兵庫県神戸市）
- Year and Date
  2015-10-22
- Data Source
  KAKENHI-PROJECT-25461483
[Presentation] BAFF受容体（BR3）を標的としたシェーグレン症候群治療薬の探索2015
- Author(s)
  吉本桂子
- Organizer
  第24回日本シェーグレン症候群学会
- Place of Presentation
  京王プラザホテル（東京都新宿区）
- Year and Date
  2015-09-18
- Data Source
  KAKENHI-PROJECT-25461483
[Presentation] Signal transduction via CD103 and BAFF-receptor cooperatively play a role in the abnormal activation of T cells2015
- Author(s)
  Keiko Yoshimoto
- Organizer
  Immunology 2015
- Place of Presentation
  New Orleans, USA
- Year and Date
  2015-05-08
- Data Source
  KAKENHI-PROJECT-25461483
[Presentation] BAFF induces IL-6 production in human monocytes through signaling pathways that involve NF-kB and PI3 kinase.2013
- Author(s)
  Keiko Yoshimoto,Maiko Tanaka, Masako Kojima, Hideko Ogata, Katsuya Suzuki, Hideto kameda, Tohru Abe, Tsutomu Takeuchi
- Organizer
  International Congress of Immunology 2013
- Place of Presentation
  Milano, Italy
- Data Source
  KAKENHI-PROJECT-25461483
[Presentation] BAFF enhances the production of matrixmetalloproteinase-9 by peripheral monocytes of patients with primary Sjoegren’s syndrome through signaling pathways that involve NF-kB and PI3 kinase.2013
- Author(s)
  Keiko Yoshimoto,Maiko Tanaka, Masako Kojima, Hideko Ogata, Katsuya Suzuki, Hideto kameda, Tohru Abe, Tsutomu Takeuchi
- Organizer
  12th International Symposium on Sjoegren’s syndrome
- Place of Presentation
  Kyoto, Japan
- Data Source
  KAKENHI-PROJECT-25461483
[Presentation] NF-kB is involved in abnormalBAFF signaling inperipheralmonocytes of patients with primary Sjoegren's syndrome.2013
- Author(s)
  Keiko Yoshimoto,Maiko Tanaka, Masako Kojima, Hideko Ogata, Katsuya Suzuki, Hideto kameda, Tohru Abe, Tsutomu Takeuchi
- Organizer
  Immunology 2013
- Place of Presentation
  Honolulu, USA
- Data Source
  KAKENHI-PROJECT-25461483
[Presentation] Increased expression of BAFF receptor on monocytes is a contributory factor of hypergammaglobulinemia in patients with primary Sjoegren's syndrome.2013
- Author(s)
  Keiko Yoshimoto,Maiko Tanaka, Masako Kojima, Hideko Ogata, Katsuya Suzuki, Hideto kameda, Tohru Abe, Tsutomu Takeuchi
- Organizer
  American College of Rheumatology Annual Meeting
- Place of Presentation
  San Diego, USA
- Data Source
  KAKENHI-PROJECT-25461483
[Presentation] BAFF induces production of matrix metalloproteinase-9 by peripheral monocytes in patients with primary Sjoegren’s syndrome through a signaling pathway that involves NF-kB and PI3 kinase.2013
- Author(s)
  Keiko Yoshimoto,Maiko Tanaka, Masako Kojima, Hideko Ogata, Katsuya Suzuki, Hideto kameda, Tohru Abe, Tsutomu Takeuchi
- Organizer
  American College of Rheumatology Annual Meeting
- Place of Presentation
  San Diego, USA
- Data Source
  KAKENHI-PROJECT-25461483
[Presentation] シェーグレン症候群患者末単球における BAFF シグナル異常の解析2012
- Author(s)
  吉本桂子
- Organizer
  第21回日本シェーグレン症候群学会
- Place of Presentation
  京都
- Year and Date
  2012-09-07
- Data Source
  KAKENHI-PROJECT-22591084
[Presentation] BAFF signaling is abnormally regulated through JAK pathways in monocytes with primary Sjogren's syndrome2012
- Author(s)
  Yoshimoto K., et al
- Organizer
  EULAR 2012
- Place of Presentation
  ベルリン、ドイツ
- Year and Date
  2012-06-08
- Data Source
  KAKENHI-PROJECT-22591084
[Presentation] JAK-STAT pathways may be involved in enhanced production of IL-6 by BAFF in human monocytes2012
- Author(s)
  吉本桂子
- Organizer
  第56回日本リウマチ学会
- Place of Presentation
  東京
- Year and Date
  2012-04-21
- Data Source
  KAKENHI-PROJECT-22591084
[Presentation] JAK-STAT pathways are involved in the BAFF signaling of peripheral monocytes of patients with primary Sjögren’s syndrome.2012
- Author(s)
  Keiko Yoshimoto
- Organizer
  American Association of Immunologist Annual Meeting 2012
- Place of Presentation
  Boston　USA
- Data Source
  KAKENHI-PROJECT-22591084
[Presentation] BAFF signaling is abnormally regulated through JAK pathways in2012
- Author(s)
  Keiko Yoshimoto
- Organizer
  EULAR 2012
- Place of Presentation
  Berlin　Germany
- Data Source
  KAKENHI-PROJECT-22591084
[Presentation] Aberrant expression of BAFF receptor (BR3) in peripheral monocytes of patients with primary Sjögren’s syndrome impacts abnormal activation of BAFF signaling through IKK-alpha　and IKK-beta2012
- Author(s)
  Keiko Yoshimoto
- Organizer
  American College of Rheumatology Annual Meeting 2012
- Place of Presentation
  Washington DC USA
- Data Source
  KAKENHI-PROJECT-22591084
[Presentation] JAK-STAT pathways are involved in the BAFF signaling of peripheral monocytes of patients with primary Sjogren's syndrome2012
- Author(s)
  Yoshimoto K., et al
- Organizer
  Immunology 2012
- Place of Presentation
  ボストン、米国
- Year and Date
  2012-05-08
- Data Source
  KAKENHI-PROJECT-22591084
[Presentation] JAK-STAT pathways may be involved in enhanced production of IL-6 by BAFF in human monocytes.2012
- Author(s)
  吉本　桂子
- Organizer
  日本リウマチ学会総会学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22591084
[Presentation] JAK3 is involved in BAFF-mediated abnormal production of IL-6 by peripheral monocytes of patients with primary Sjogren's syndrome2012
- Author(s)
  Yoshimoto K., et al.
- Organizer
  Cytokines 2012
- Place of Presentation
  ジュネーブ、スイス
- Year and Date
  2012-09-12
- Data Source
  KAKENHI-PROJECT-22591084
[Presentation] JAK3 is involved in BAFF-mediated abnormal production of IL-6 by peripheral monocytes of patients with primary Sjögren’s syndrome2012
- Author(s)
  Keiko Yoshimoto
- Organizer
  Cytokines 2012
- Place of Presentation
  Geneva Switzerland
- Data Source
  KAKENHI-PROJECT-22591084
[Presentation] シェーグレン症候群患者末単球におけるBAFFシグナル異常の解析2012
- Author(s)
  吉本　桂子
- Organizer
  第21回日本シェーグレン症候群学会
- Place of Presentation
  京都
- Invited
- Data Source
  KAKENHI-PROJECT-22591084
[Presentation] Aberrant expression of BAFF receptor (BR3) in peripheral monocytes of patients with primary Sjogren's syndrome impacts abnormal activation of BAFF signaling through IKK-alpha and IKK-beta2012
- Author(s)
  Yoshimoto K., et al
- Organizer
  American College of Rheumatology Annual Meeting 2012
- Place of Presentation
  ワシントンDC、米国
- Year and Date
  2012-11-10
- Data Source
  KAKENHI-PROJECT-22591084
[Presentation] A JAK3 pathway may be involved in the production of IL-6 by human monocytes stimulated with BAFF2011
- Author(s)
  Keiko Yoshimoto
- Organizer
  Immunology 2011
- Place of Presentation
  San Francisco (USA) Moscone Center
- Year and Date
  2011-05-14
- Data Source
  KAKENHI-PROJECT-22591084
[Presentation] シェーグレン症候群患者末単球からの IL-6 産生と BAFF シグナルの関与2011
- Author(s)
  吉本桂子
- Organizer
  第20回日本シェーグレン症候群学会
- Place of Presentation
  金沢
- Year and Date
  2011-09-10
- Data Source
  KAKENHI-PROJECT-22591084
[Presentation] Possible involvement of JAK3 pathway in production of IL-6 induced by BAFF in peripheral monocytes of patients with primary Sjogren's syndrome2011
- Author(s)
  Keiko Yoshimoto
- Organizer
  第40回日本免疫学会総会学術集会
- Place of Presentation
  幕張メッセ(千葉)
- Year and Date
  2011-11-29
- Data Source
  KAKENHI-PROJECT-22591084
[Presentation] A JAK3 pathway may be involved in the production of IL-6 by human monocytes stimulated with BAFF.2011
- Author(s)
  Yoshimoto K., et al.
- Organizer
  Immunology 2011
- Place of Presentation
  サンフランシスコ、米国
- Year and Date
  2011-05-15
- Data Source
  KAKENHI-PROJECT-22591084
[Presentation] ヒト単球からのBAFF 誘導型IL-6産生における JAK 経路の関与2011
- Author(s)
  吉本桂子
- Organizer
  第55回日本リウマチ学会総会学術集会
- Place of Presentation
  神戸
- Year and Date
  2011-07-20
- Data Source
  KAKENHI-PROJECT-22591084
[Presentation] Abnormalities in a JAK-STAT pathway are involved in the aberrant production of IL-6 by BAFF-stimulated peripheral monocytes of patients with primary Sjogren's syndrome2011
- Author(s)
  Yoshimoto K., et al.
- Organizer
  American College of Rheumatology
- Place of Presentation
  シカゴ、米国
- Year and Date
  2011-11-08
- Data Source
  KAKENHI-PROJECT-22591084
[Presentation] ヒト単球からのBAFF誘導型IL-6産生におけるJAK経路の関与2011
- Author(s)
  吉本桂子
- Organizer
  第55回日本リウマチ学会総会学術集会
- Place of Presentation
  ポートピアホテル(兵庫)
- Year and Date
  2011-07-18
- Data Source
  KAKENHI-PROJECT-22591084
[Presentation] Possible involvement of JAK3 pathway in production of IL-6 induced by BAFF in human monocytes2011
- Author(s)
  Yoshimoto K., et al
- Organizer
  4^<th>East Asian Group of Rheumatology
- Place of Presentation
  東京
- Year and Date
  2011-10-15
- Data Source
  KAKENHI-PROJECT-22591084
[Presentation] REGULATION OF IL-6 PRODUCTION INDUCED BY SOLUBLE BAFF IN MONOCYTES OF PATIENTS WITH PRIMARY SJOGREN'S SYNDROME2011
- Author(s)
  Keiko Yoshimoto
- Organizer
  11^<th> International Symposium for Sjogren's syndrome
- Place of Presentation
  Athens Athenaeum intercontinental Hotel(ギリミャ)
- Year and Date
  2011-09-30
- Data Source
  KAKENHI-PROJECT-22591084
[Presentation] Abnormalities in a JAK-STAT pathway are involved in the aberrant production of IL-6 by BAFF-stimulated peripheral monocytes of patients with primary Sjogren's syndrome2011
- Author(s)
  Keiko Yoshimoto
- Organizer
  American College of Rheumatology 2011
- Place of Presentation
  Chicago McCormick Place (Convention Center)(USA)
- Year and Date
  2011-11-06
- Data Source
  KAKENHI-PROJECT-22591084
[Presentation] REGULATION OF IL-6 PRODUCTION INDUCED BY SOLUBLE BAFF IN MONOCYTES OF PATIENTS WITH PRIMARY SJoGREN'S SYNDROME2011
- Author(s)
  Yoshimoto K., et al
- Organizer
  11^<th> International Symposium for Sjogren's syndrome
- Place of Presentation
  アテネ、ギリシャ
- Year and Date
  2011-09-29
- Data Source
  KAKENHI-PROJECT-22591084
[Presentation] Possible involvement of JAK3 pathway in production of IL-6 induced by BAFF in human monocytes2011
- Author(s)
  Keiko Yoshimoto
- Organizer
  4^<th> East Asian Group of Rheumatology
- Place of Presentation
  京王プラザホテル(東京)
- Year and Date
  2011-10-15
- Data Source
  KAKENHI-PROJECT-22591084
[Presentation] Possible involvement of JAK3 pathway in production of IL-6 induced by BAFF in peripheral monocytes of patients with primary Sjogren's syndrome2011
- Author(s)
  Yoshimoto K., et al
- Organizer
  第40回日本免疫学会総会学術集会
- Place of Presentation
  千葉
- Year and Date
  2011-11-29
- Data Source
  KAKENHI-PROJECT-22591084
[Presentation] シェーグレン症候群患者末単球からのIL-6産生とBAFFシグナルの関与2011
- Author(s)
  吉本桂子
- Organizer
  第20回日本シェーグレン症候群学会
- Place of Presentation
  ホテル金沢(石川)
- Year and Date
  2011-09-09
- Data Source
  KAKENHI-PROJECT-22591084
[Presentation] Up-regulated signaling pathway triggered by sBAFF may induce aberrant production of IL-6 in monocytes of the patients with Sjogren's Syndrome2010
- Author(s)
  Yoshimoto K., at al.
- Organizer
  Immunology 2010
- Place of Presentation
  ボルチモア, 米国
- Year and Date
  2010-05-08
- Data Source
  KAKENHI-PROJECT-22591084
[Presentation] Up-regulated signaling pathway triggered by sBAFF may induce aberrant production of IL-6 in monocytes of the patients with Sjogren's Syndrome2010
- Author(s)
  吉本桂子
- Organizer
  Immunology 2010
- Place of Presentation
  ボルチモア(米国)
- Year and Date
  2010-05-11
- Data Source
  KAKENHI-PROJECT-22591084
[Presentation] シェーグレン症候群患者の末梢単球およびT細胞における BAFF産生異常機構と病態形成への関与2010
- Author(s)
  吉本桂子
- Organizer
  第19回日本シェーグレン症候群学会
- Place of Presentation
  舞浜市
- Year and Date
  2010-09-10
- Data Source
  KAKENHI-PROJECT-22591084
[Presentation] ヒト単球からのBAFF誘導型IL-6産生機構の解明2010
- Author(s)
  吉本桂子
- Organizer
  第75回日本インターフェロン・サイトカイン学会
- Place of Presentation
  北九州市
- Year and Date
  2010-06-26
- Data Source
  KAKENHI-PROJECT-22591084
[Presentation] シェーグレン症候群患者末梢単球におけるBAFFシグナル異常の解析2010
- Author(s)
  吉本桂子
- Organizer
  シェーグレン症候群セミナー
- Place of Presentation
  東京(招待講演)
- Year and Date
  2010-05-23
- Data Source
  KAKENHI-PROJECT-22591084
[Presentation] ヒト単球からのBAFF 誘導型IL-6産生機構の解明2010
- Author(s)
  吉本桂子
- Organizer
  第75回日本インターフェロン・サイトカイン学会
- Place of Presentation
  北九州市
- Year and Date
  2010-06-26
- Data Source
  KAKENHI-PROJECT-22591084
[Presentation] シェーグレン症候群患者の末梢単球およびT細胞におけるBAFF産生異常機構と病態形成への関与2010
- Author(s)
  吉本桂子
- Organizer
  第19回日本シェーグレン症候群学会
- Place of Presentation
  舞浜市
- Year and Date
  2010-09-10
- Data Source
  KAKENHI-PROJECT-22591084
[Presentation] シェーグレン症候群患者末梢単球における BAFF シグナル異常の解析2010
- Author(s)
  吉本桂子
- Organizer
  シェーグレンセミナー 2010
- Place of Presentation
  東京
- Year and Date
  2010-06-05
- Data Source
  KAKENHI-PROJECT-22591084
[Presentation] The expression of an integrin α Eβ7 may induce abnormal T cell activation.2008
- Author(s)
  K. Yoshimoto, C. Kumazawa, K. Tsuzaka, T. Abe, T. Takeuchi.
- Organizer
  9th annual meeting for European League Aginst Rheumatisam
- Place of Presentation
  フランス(パジ)
- Year and Date
  2008-06-14
- Data Source
  KAKENHI-PROJECT-20591193
[Presentation] The expression of an integrin αEβ7 may induce abnormal T cell activation.2008
- Author(s)
  K. Yoshimoto, C. Kumazawa, K. Tsuzaka, T. Abe, T. Takeuchi
- Organizer
  9th annual meeting for European League Aginst Rheumatisam
- Place of Presentation
  フランス(パリ)
- Year and Date
  2008-06-14
- Data Source
  KAKENHI-PROJECT-20591193
[Presentation] 14-kd protein binds to the conservative region in TCR zeta mRNA 3' UTR and regulates the production of TCR zeta and TCR/CD3 complex2007
- Author(s)
  Tsuzaka, K, Itami, Y, Kumazawa, C, Setoyama, Y, Yoshimoto, K, Suzuki, K, Abe, T, Takeuchi, T
- Organizer
  American College of Rheumatology 71st Annual Meeting
- Place of Presentation
  Boston, U. S. A
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591122
[Presentation] Possible involvement of MMP in the production of soluble BAFF in human T cells.2007
- Author(s)
  Yoshimoto Keiko
- Organizer
  The EULAR annual congress of rheumatology
- Place of Presentation
  Barcelona,Spain
- Data Source
  KAKENHI-PROJECT-18591122
[Presentation] Possible involvement of MMP-9 in the production of BAFF in T cells.2007
- Author(s)
  Yoshimoto Keiko
- Organizer
  American College of Rheumatology, 71st Annual Meeting
- Place of Presentation
  Boston,U.S.A
- Data Source
  KAKENHI-PROJECT-18591122
[Presentation] Possible involvement of MMP in the production of soluble BAFF in human T cells2007
- Author(s)
  Yoshimoto, K, Takahashi, Y, Setoyama, Y, Suzuki, K, Tsuzaka, K, Abe, T, Takeuchi, T
- Organizer
  The EULAR annual congress of rheumatology, Barcelona
- Place of Presentation
  Spain
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591122
[Presentation] Decreased expression of the glycosylated syndecan 4 accompanied with down-regulation of TCR zeta in SLE patient T cells2007
- Author(s)
  Tsuzaka, K, Itami, Y, Kumazawa, C, Setoyama, Y, Yoshimoto, K, Suzuki, K, Abe, T, Takeuchi, T
- Organizer
  American College of Rheumatology 71st Annual Meeting
- Place of Presentation
  Boston, U. S. A
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591122
[Presentation] TCR ξ and TCR/CD3 expression from the TCR C mRNA with deleted form of the conservative sequences in 3' UTR is down-regulated due to its instability2007
- Author(s)
  Tsuzaka, K, Itami, Y, Kumazawa, C, Setoyama, Y, Yoshimoto, K, Suzuki, K, Abe, T, Takeuchi, T
- Organizer
  37th Japanese society for Immunology
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591122
[Presentation] Possible involvement of MMP-9 in the production of BAFF in T cells2007
- Author(s)
  Yoshimoto, K, Setoyama, Y, Tsuzaka, K, Ogawa, Y, Tsubota, K, Abe, T, Takeuchi, T
- Organizer
  American uollege of Nheumatology Ylst Annual Meeting
- Place of Presentation
  Boston, U. S. A
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591122
[Presentation] ヒトT細胞BAFF産生制御機構におけるMMPの関与2006
- Author(s)
  吉本桂子
- Organizer
  第34回日本臨床免疫学会総会
- Place of Presentation
  東京
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18591122
[Presentation] シェーグレン症候群患者末梢T細胞におけるBAFF産生制御機構の検討2006
- Author(s)
  吉本桂子
- Organizer
  第50回日本リウマチ学会総会
- Place of Presentation
  長崎
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18591122
[Presentation] Possible mechanism of production of soluble BAFF in human T cells.第36回日本免疫学会総会、2006年122006
- Author(s)
  Yoshimoto Keiko
- Organizer
  第36回日本免疫学会総会
- Place of Presentation
  大阪
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18591122
[Presentation] Aberrant expression of BAFF in SLE T cells2006
- Author(s)
  Yoshimoto, K, Takahashi, Y, Setoyama, Y, Suzuki. K, Tsuzaka. K, Abe. T, Takeuchi, T
- Organizer
  The EULAR annual congress of rheumatology
- Place of Presentation
  Amsterdam, Holland
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591122
[Presentation] BAFF activates monocytes to produce IL-6 though BAFF receptor(BR3) for IgG production from peripheral B cells in patients with primary Sjｏgren's syndrome.
- Author(s)
  Keiko Yoshimoto, Eriko Ishioka, Ayumi Nishikawa, Katsuya Suzuki, Hideto Kameda, Tohru Abe and Tsutomu Takeuchi
- Organizer
  第58回日本リウマチ学会総会・学術集会
- Place of Presentation
  東京グランドプリンスホテル新高輪
- Year and Date
  2014-04-24 – 2014-04-26
- Data Source
  KAKENHI-PROJECT-25461483
[Presentation] 一次性シェーグレン症候群患者末梢単球機能異常の抗体産生への関与
- Author(s)
  吉本桂子、石岡江梨子、西川あゆみ、鈴木勝也、安倍　達、竹内　勤
- Organizer
  第35回日本再生・炎症医学会
- Place of Presentation
  沖縄県那覇市、万国津梁館
- Year and Date
  2014-07-01 – 2014-07-04
- Data Source
  KAKENHI-PROJECT-25461483
[Presentation] BAFF-induced IL-6 signaling plays a pivotal role in interactions between monocytes and B cells that accelerate IgG overproduction in patients with primary Sjｏgren’s syndrome.
- Author(s)
  Keiko Yoshimoto, Eriko Ishioka, Ayumi Nishikawa, Katsuya Suzuki, Hideto Kameda, Tohru Abe, Tsutomu Takeuchi
- Organizer
  ＥＵＬＡＲ　２０１４
- Place of Presentation
  Paris, France
- Year and Date
  2014-06-11 – 2014-06-14
- Data Source
  KAKENHI-PROJECT-25461483
[Presentation] BAFF induces production of IL-6 and matrix metalloproteinase-9 by peripheral monocytes of patients with primary Sjｏgren’s syndrome through multiple signaling pathways.
- Author(s)
  Keiko Yoshimoto, Eriko Ishioka, Ayumi Nishikawa, Katsuya Suzuki, Hideto Kameda, Tohru Abe, Tsutomu Takeuchi
- Organizer
  第43回日本免疫学会学術集会
- Place of Presentation
  京都府京都市　国立京都国際会館
- Year and Date
  2014-12-10 – 2014-12-12
- Data Source
  KAKENHI-PROJECT-25461483
[Presentation] Pyrrolopyrimidine derivatives that inhibit binding of BAFF to its receptor, BR3, are drug candidates for primary Sjｏgren's syndrome.
- Author(s)
  Keiko Yoshimoto, Eriko Ishioka, Katsuya Suzuki, Takahiro Ito, Tomohiro Sugano, Ayumu Okuda, Hiroyuki Ishiwata, Takeshi Doi, Takatsugu Hirokawa, Tsutomu Takeuchi
- Organizer
  ACR/ARHP Annual Meeting 2014
- Place of Presentation
  Ｂｏｓｔｏｎ, USA
- Year and Date
  2014-11-14 – 2014-11-18
- Data Source
  KAKENHI-PROJECT-25461483
[Presentation] シェーグレン症候群患者末梢単球上のBAFF受容体発現亢進が関与する病態形成機序の検討
- Author(s)
  吉本桂子　竹内　勤
- Organizer
  第23回日本シェーグレン症候群学会
- Place of Presentation
  長崎県長崎市、ホテルニュー長崎
- Year and Date
  2014-09-12 – 2014-09-13
- Invited
- Data Source
  KAKENHI-PROJECT-25461483
[Presentation] BAFF induces IL-6 production by monocytes through a BAFF receptor and promotes IgG production by B cells in patients with primary Sjｏgren's syndrome.
- Author(s)
  Keiko Yoshimoto, Masako Kojima, Hideko Ogata, Eriko Ishioka, Ayumi Nishikawa, Katsuya Suzuki, Hideto Kameda, Tohru Abe, Tsutomu Takeuchi
- Organizer
  Immunology 2014
- Place of Presentation
  Pittsburgh, USA
- Year and Date
  2014-05-02 – 2014-05-06
- Data Source
  KAKENHI-PROJECT-25461483

1. TAKEUCHI Tsutomu (50179610)

# of Collaborated Projects: 4 results

# of Collaborated Products: 20 results
2. KAMEDA Hideto (00265795)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
3. TSUZAKA Kensei (00245490)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. Yamaoka Kunihiro (20425317)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. Ikeda Yumi (70826156)

# of Collaborated Projects: 1 results

# of Collaborated Products: 16 results
6. 白石清之 (10383291)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. SUZUKI Katsuya

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 津坂憲政

# of Collaborated Projects: 0 results

# of Collaborated Products: 10 results
9. 高梨敏史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 森田林平

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
11. 竹馬俊介

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 秋山光浩

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 近藤泰

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 金子祐子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 松本紘太郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Yoshimoto Keiko 吉本 桂子

YOSHIMOTO Keiko 吉本 桂子

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B細胞機能制御作用を有する低分子化合物を用いたSLE新規治療標的分子の探索Principal Investigator

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Elucidation of the regulatory mechanisms of the crosstalk between BAFF signaling and Nav channel in monocytes aiming at development of radical therapy for Sj&ouml;grens syndrome.Principal Investigator

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Elucidation of molecular mechanisms of monocyte activation through TLR signaling in Sj&ouml;grens syndrome.

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Function and clinical application of MS4A4A involved in pathology of rheumatoid arthritis

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Exploration of therapeutic targets which are involved in the pathogenesis of Sjogren's syndrome aiming at ion channels.Principal Investigator

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Discovery of therapeutic targets for Sjogren's syndromePrincipal Investigator

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Search for BAFF signaling inhibitors as novel drugs for the treatment of Sjogren's syndrome.Principal Investigator

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Analysis on signal transduction pathway through CD103 molecule

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Molecular mechanism and its regulation of heterophilic adhesion between α E 3 7 (CD103) and E-cadherin in autoimmune epithelial injury

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[Journal Article] Effects of interleukin-6 signal inhibition on Treg subpopulations and association of Tregs with clinical outcomes in rheumatoid arthritis2024

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[Journal Article] Cytotoxic Tph subset with low B-cell helper functions and its involvement in systemic lupus erythematosus2024

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[Journal Article] Sodium benzoate attenuates 2,8-dihydroxyadenine nephropathy by inhibiting monocyte/macrophage TNF-α expression2023

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[Journal Article] Significant association of CX3CR1+CD8 T cells with aging and distinct clinical features in Sj?gren's syndrome and IgG4-related disease2023

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[Journal Article] Distinct gene signatures of monocytes and B cells in patients with giant cell arteritis: a longitudinal transcriptome analysis2023

Yoshimoto Keiko 吉本桂子

YOSHIMOTO Keiko 吉本桂子

Elucidation of the regulatory mechanisms of the crosstalk between BAFF signaling and Nav channel in monocytes aiming at development of radical therapy for Sjögrens syndrome.Principal Investigator

Elucidation of molecular mechanisms of monocyte activation through TLR signaling in Sjögrens syndrome.