UEYAMA Morio 上山盛夫

Researcher Number	20386593
Affiliation (based on the past Project Information) *help	2021 – 2023: 近畿大学, 医学部, 定時職員 2016 – 2019: 大阪大学, 医学系研究科, 特任助教 2015: 国立研究開発法人国立精神・神経医療研究センター, 神経研究所疾病研究第四部, 科研費研究員 2013 – 2014: 独立行政法人国立精神・神経医療研究センター, 神経研究所疾病研究第四部, 科研費研究員
Review Section/Research Field	Principal Investigator Neurology / Basic Section 52020:Neurology-related / Basic Section 51030:Pathophysiologic neuroscience-related Except Principal Investigator Basic Section 52020:Neurology-related
Keywords	Principal Investigator ショウジョウバエ / リピート関連非ATG翻訳 / SCA31 / 染色体欠失 / スクリーニング / C9-ALS/FTD / ノンコーディングリピート病 / RAN翻訳 / 異常伸長リピートRNA / RNAリピート病 … More / 異常伸長リピート / 前頭側頭葉変性症 / 筋萎縮性側索硬化症 / RNA結合蛋白質 / 遺伝子 / RNA / 脳神経疾患 / 脳・神経 … More Except Principal Investigator 液-液相分離 / ショウジョウバエ / 微小管輸送 / 凝集体 / アミロイド / 非膜性オルガネラ / 液－液相分離 / 蛋白質 / 脳神経疾患 Less

リピート関連非AUG翻訳調節によるノンコーディングリピート病の病態制御Principal Investigator
- Principal Investigator
  
  上山盛夫
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Kindai University
Elucidation of regulation mechanisms of LLPS leading to pathological protein aggregation in neurodegenerative diseases
- Principal Investigator
  
  Nagai Yoshitaka
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Kindai University
Elucidation of the mechanism of repeat-associated non-ATG translationPrincipal Investigator
- Principal Investigator
  
  上山盛夫
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Kindai University
  Osaka University
Elucidation of the pathogenic mechanisms of ALS/FTLD by identifying molecules related to repeat-associated non-ATG translationPrincipal Investigator
- Principal Investigator
  
  Ueyama Morio
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Osaka University
  National Center of Neurology and Psychiatry
Establishment of a novel animal model of ALS expressing GGGGCC repeat RNA in Drosophila, and analyses of its pathogenic mechanismsPrincipal Investigator
- Principal Investigator
  
  UEYAMA Morio
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurology
- Research Institution
  National Center of Neurology and Psychiatry

All 2024 2023 2021 2019 2018 2017 2016 2015 2014 Other

All Journal Article Presentation Patent

[Journal Article] Dysregulation of stress granule dynamics by DCTN1 deficiency exacerbates TDP-43 pathology in Drosophila models of ALS/FTD.2024
- Author(s)
  Ueda T, Takeuchi T, Fujikake N, Suzuki M, Minakawa EN, Ueyama M, Fujino Y, Kimura N, Nagano S, Yokoseki A, Onodera O, Mochizuki H, Mizuno T, Wada K, Nagai Y.
- Journal Title
  
  Acta Neuropathol Commun
  
  Volume: 12 Issue: 1 Pages: 20-20
- DOI
  10.1186/s40478-024-01729-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K18265, KAKENHI-PROJECT-22K19762, KAKENHI-PROJECT-21H02841, KAKENHI-PUBLICLY-22H04811, KAKENHI-PROJECT-21H02840
[Journal Article] Reconstitution of C9orf72 GGGGCC repeat-associated non-AUG translation with purified human translation factors.2023
- Author(s)
  Ito H., Machida K., Ueyama M., Nagai Y., Imataka H., Taguchi H.
- Journal Title
  
  Sci. Rep.
  
  Volume: 13(1) Issue: 1 Pages: 22826-22826
- DOI
  10.1038/s41598-023-50188-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H02840, KAKENHI-PROJECT-23K23875
[Journal Article] Therapeutic reduction of GGGGCC repeat RNA levels by hnRNPA3 suppresses neurodegeneration in Drosophila models of C9orf72-linked ALS/FTD2023
- Author(s)
  Taminato Tomoya、Takeuchi Toshihide、Ueyama Morio、Mori Kohji、Ikeda Manabu、Mochizuki Hideki、Nagai Yoshitaka
- Journal Title
  
  Human Molecular Genetics
  
  Volume: 32 Issue: 10 Pages: 1673-1682
- DOI
  10.1093/hmg/ddac298
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K19492, KAKENHI-PROJECT-20H03602, KAKENHI-PLANNED-20H05927, KAKENHI-PROJECT-23K24054, KAKENHI-PROJECT-21H02840
[Journal Article] Arylsulfatase A, a genetic modifier of Parkinson's disease, is an α-synuclein chaperone.2019
- Author(s)
  J. S. Lee, K. Kanai, M. Suzuki, W. S. Kim, H. S. Yoo, Y. Fu, D-K. Kim, B. C. Jung, M. Choi, K. W. Oh, Y. Li, M. Nakatani, T. Nakazato, S. Sekimoto, M. Furuyama, H. Yoshino, S. Kubo, K. Nishioka, R. Sakai, M. Ueyama, H. Mochizuki, H-J. Lee, S. P. Sardi, G. M. Halliday, Y. Nagai, P. H. Lee, N. Hattori, S-J. Lee
- Journal Title
  
  Brain
  
  Volume: 142 Issue: 9 Pages: 2845-59
- DOI
  10.1093/brain/awz205
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07823, KAKENHI-PROJECT-19K07987, KAKENHI-PROJECT-19K08003, KAKENHI-PROJECT-17K09811, KAKENHI-PROJECT-17K19658, KAKENHI-PUBLICLY-17H05699, KAKENHI-PROJECT-16H05325
[Journal Article] 神経変性疾患にかかわるリピート関連非ATG依存性翻訳と低複雑性ドメイン2019
- Author(s)
  上山盛夫、永井義隆
- Journal Title
  
  実験医学
  
  Volume: 37 Pages: 3070-6
- Data Source
  KAKENHI-PROJECT-19K07823
[Journal Article] E46K mutantα-synuclein is more degradation resistant and exhibits greater toxic effects than wild-typeα-synuclein in Drosophila models of Parkinson's disease.2019
- Author(s)
  R. Sakai, M. Suzuki, M. Ueyama, T. Takeuchi, E. N. Minakawa, H. Hayakawa, K. Baba, H. Mochizuki, Y. Nagai
- Journal Title
  
  PLoS ONE
  
  Volume: 14 Issue: 6 Pages: e0218261-e0218261
- DOI
  10.1371/journal.pone.0218261
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07823, KAKENHI-PROJECT-19K07987, KAKENHI-PROJECT-17K19658, KAKENHI-PUBLICLY-17H05699, KAKENHI-PROJECT-16H05325
[Journal Article] Overexpressin of ter94, Drosophila VCP, improves motor neuron degeneration induced by knockdown of TBPH, Drosophila TDP-432018
- Author(s)
  Kushimura Yukie、Tokuda Takahiro、Azuma Yumiko、Yamamoto Itaru、Mizuta Ikuko、Mizuno Toshiki、Nakagawa Masanori、Ueyama Morio、Nagai Yoshitaka、Yoshida Hideki、Yamaguchi Masamitsu
- Journal Title
  
  American Journal of Neurodegenerative Disease
  
  Volume: 7 Pages: 11-31
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09331
[Journal Article] NPM-hMLF1 fusion protein suppresses defects of a Drosophila FTLD model expressing the human FUS gene.2018
- Author(s)
  Yamamoto I, Azuma Y, Kushimura Y, Yoshida H, Mizuta I, Mizuno T, Ueyama M, Nagai Y, Tokuda T, Yamaguchi M.
- Journal Title
  
  Sci. Rep.
  
  Volume: 8 Issue: 1 Pages: 11291-11291
- DOI
  10.1038/s41598-018-29716-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07385, KAKENHI-PROJECT-17K07500, KAKENHI-PROJECT-17K19658, KAKENHI-PROJECT-16K07346, KAKENHI-PROJECT-16K19519, KAKENHI-PUBLICLY-17H05699, KAKENHI-PROJECT-16H05325, KAKENHI-PROJECT-15K09331
[Journal Article] Hippo, Drosophila MST, is a novel modifier of motor neuron degeneration induced by knockdown of Caz, Drosophila FUS.2018
- Author(s)
  Azuma Y, Tokuda T, Kushimura Y, Yamamoto I, Mizuta I, Mizuno T, Nakagawa M, Ueyama M, Nagai Y, Iwasaki Y, Yoshida M, Pan D, Yoshida H, Yamaguchi M.
- Journal Title
  
  Exp Cell Res.
  
  Volume: 371 Issue: 2 Pages: 311-321
- DOI
  10.1016/j.yexcr.2018.08.001
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07385, KAKENHI-PROJECT-17K07500, KAKENHI-PROJECT-17K19658, KAKENHI-PROJECT-16K07346, KAKENHI-PROJECT-16K19519, KAKENHI-PUBLICLY-17H05699, KAKENHI-PROJECT-16H05325, KAKENHI-PROJECT-15K09331
[Journal Article] C9orf72連鎖性筋萎縮性側索硬化症・前頭側頭型認知症における病態メカニズム2018
- Author(s)
  上山盛夫, 永井義隆
- Journal Title
  
  医学のあゆみ
  
  Volume: 267 Pages: 817-822
- Data Source
  KAKENHI-PROJECT-15K09331
[Journal Article] Parkinson’s disease-linked DNAJC13 mutation aggravates α-synuclein-induced neurotoxicity through perturbation of endosomal trafficking.2018
- Author(s)
  Yoshida S, Hasegawa T, Suzuki M, Sugeno N, Kobayashi J, Ueyama M, Fukuda M, Ido-Fujibayashi A, Sekiguchi K, Ezura M, Kikuchi A, Baba T, Takeda A, Mochizuki H, Nagai Y and Aoki M.
- Journal Title
  
  Hum Mol Genet.
  
  Volume: 27 Issue: 5 Pages: 823-836
- DOI
  10.1093/hmg/ddy003
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09744, KAKENHI-PROJECT-17K09745, KAKENHI-PROJECT-17K19658, KAKENHI-PROJECT-17K16134, KAKENHI-PROJECT-16H05325, KAKENHI-PUBLICLY-17H05682, KAKENHI-PUBLICLY-17H05683, KAKENHI-PROJECT-26461303, KAKENHI-PROJECT-15K19502, KAKENHI-PROJECT-17K09789, KAKENHI-PROJECT-15K09331
[Journal Article] Regulatory Role of RNA Chaperone TDP-43 for RNA Misfolding and Repeat-Associated Translation in SCA312017
- Author(s)
  Taro Ishiguro, Nozomu Sato, Morio Ueyama, Nobuhiro Fujikake, Chantal Sellier, Akemi Kanegami, Eiichi Tokuda, Bita Zamiri, Terence Gall-Duncan, Mila Mirceta, Yoshiaki Furukawa, 他８名
- Journal Title
  
  Neuron
  
  Volume: 94 Issue: 1 Pages: 108-124
- DOI
  10.1016/j.neuron.2017.02.046
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01566, KAKENHI-PROJECT-15H06181, KAKENHI-PROJECT-15H06588, KAKENHI-PROJECT-17K15077, KAKENHI-PROJECT-16H05325, KAKENHI-PROJECT-15K09331
[Journal Article] 神経変性疾患への新しい視点 –プリオン仮説- D.タウ蛋白による前頭側頭葉変性症 (FTLD-Tau) 3.その他のFTLD (異常蛋白の視点から)2015
- Author(s)
  上山盛夫、藤掛伸宏、永井義隆
- Journal Title
  
  Clinical Neurosci.
  
  Volume: 33 Pages: 312-314
- Data Source
  KAKENHI-PROJECT-15K09331
[Journal Article] p62 plays a protective role in the autophagic degradation of polyglutamine protein oligomers in polyglutamine disease model flies.2015
- Author(s)
  Saitoh Y, Fujikake N, Okamoto Y, Popiel HA, Hatanaka Y, Ueyama M, Suzuki M, Gaumer S, Murata M, Wada K, Nagai Y.
- Journal Title
  
  J Biol Chem
  
  Volume: 290 Issue: 3 Pages: 1442-53
- DOI
  10.1074/jbc.m114.590281
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24591286, KAKENHI-PROJECT-24591287, KAKENHI-PUBLICLY-25110741, KAKENHI-PROJECT-25860733, KAKENHI-PROJECT-26670446, KAKENHI-PROJECT-15K09331
[Journal Article] 神経変性疾患への新しい視点 -プリオン仮説- D.タウ蛋白による前頭側頭葉変性症 (FTLD-Tau) 3.その他のFTLD (異常蛋白の視点から)2015
- Author(s)
  上山盛夫、藤掛伸宏、永井義隆
- Journal Title
  
  Clinical Neurosci.
  
  Volume: 33 Pages: 312-314
- Data Source
  KAKENHI-PROJECT-25860733
[Journal Article] Identification of ter94, Drosophila VCP, as a strong modulator of motor neuron degeneration induced by knockdown of Caz, Drosophila FUS2014
- Author(s)
  Azuma Y., Tokuda T., Shimamura M., Kyotani A., Sasayama H., Yoshida T., Mizuta I., Mizuno T., Nakagawa M., Fujikake N., Ueyama M., Nagai Y., Yamaguchi M
- Journal Title
  
  Hum. Mol. Genet
  
  Volume: 23(13) Issue: 13 Pages: 3467-3480
- DOI
  10.1093/hmg/ddu055
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390237, KAKENHI-PROJECT-24570211, KAKENHI-PROJECT-24591286, KAKENHI-PROJECT-24659438, KAKENHI-PUBLICLY-25110741, KAKENHI-PROJECT-25860733, KAKENHI-PROJECT-26670446
[Patent] 脊髄小脳変性症３１型抑制剤2018
- Inventor(s)
  中谷和彦、柴田知範、永井義隆、上山盛夫
- Industrial Property Rights Holder
  中谷和彦、柴田知範、永井義隆、上山盛夫
- Industrial Property Rights Type
  特許
- Filing Date
  2018
- Data Source
  KAKENHI-PROJECT-15K09331
[Patent] 筋萎縮性側索硬化症又は前頭側頭型認知症の予防又は治療剤2017
- Inventor(s)
  永井義隆、上山盛夫
- Industrial Property Rights Holder
  永井義隆、上山盛夫
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2017-096111
- Filing Date
  2017
- Data Source
  KAKENHI-PROJECT-15K09331
[Presentation] FUSはRNAシャペロンとしてRAN翻訳を抑制し、C9orf72関連ALS/FTDの神経変性を改善する2023
- Author(s)
  藤野雄三、上山盛夫、石黒太郎、小澤大作、伊藤隼人、石黒亮、森康治、池田学、水野敏樹、望月秀樹、田口英樹、永井義隆
- Organizer
  第42回日本認知症学会
- Data Source
  KAKENHI-PROJECT-21H02840
[Presentation] Reduction of GGGGCC repeat RNA by hnRNPA3 suppresses neurodegeneration in C9orf72-ALS/FTD flies.2023
- Author(s)
  Taminato T., Takeuchi T., Ueyama M., Mori K., Ikeda M., Mochizuki H., Nagai Y.
- Organizer
  第64回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-21H02840
[Presentation] hnRNPA3によるリピートRNA発現の減少はC9orf72 ALS/FTDモデルバエの神経変性を抑制する2023
- Author(s)
  田港朝也、武内敏秀、上山盛夫、森康治、池田学、望月秀樹、永井義隆
- Organizer
  第42回日本認知症学会
- Data Source
  KAKENHI-PROJECT-21H02840
[Presentation] FUS suppresses RAN translation and neurodegeneration through modulating the G-quadruplex structure of GGGGCC repeat RNA in C9orf72-linked ALS/FTD.2023
- Author(s)
  Fujino Y., Ueyama M., Ishiguro T., Ozawa D., Ito H., Ishiguro A., Gendron T.F., Mori K., Tokuda E., Takeuchi T., Furukawa Y., Mizuno T., Onodera O., Taguchi H., Petrucelli L., Nagai Y.
- Organizer
  11th Gordon Research Conference on CAG Triplet Repeat Disorders
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02840
[Presentation] FUS suppresses RAN translation and neurodegeneration in C9orf72-linked ALS/FTD through modulating the higher-order structures of GGGGCC repeat RNA.2023
- Author(s)
  Fujino Y., Ueyama M., Ozawa D., Ito H., Taguchi H., Mizuno T., Nagai Y.
- Organizer
  第46回日本神経科学会
- Data Source
  KAKENHI-PROJECT-21H02840
[Presentation] FUS suppresses RAN translation and neurodegeneration as an RNA chaperone in C9orf72-linked ALS/FTD.2023
- Author(s)
  Fujino Y. Ueyama M., Ishiguro T., Ozawa D., Ito H., Murata A., Tokuda E., Furukawa Y., Mizuno T., Mochizuki H., Mizusawa H., Wada K., Ishikawa K., Onodera O., Nakatani K., Taguchi H., Nagai Y.
- Organizer
  第64回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-21H02840
[Presentation] Regulation of RAN translation by a repeat binding protein that modulates the structure of G4C2 repeat RNA in C9-ALS/FTD2021
- Author(s)
  M. Ueyama, T. Ishiguro, D. Ozawa, T. Sugiki, A. Ishiguro, E. Tokuda, T. Konno, A. Koyama, T. Takeuchi, Y. Furukawa, T. Fujiwara, K. Wada, O. Onodera, Y. Nagai
- Organizer
  PACTALS2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07823
[Presentation] ショウジョウバエモデルによるC9orf72関連ALS/FTDの病態解明2021
- Author(s)
  上山盛夫
- Organizer
  第40回日本認知症学会
- Invited
- Data Source
  KAKENHI-PROJECT-19K07823
[Presentation] ショウジョウバエモデルによるC9orf72関連ALS/FTDの病態解明2021
- Author(s)
  上山盛夫、石黒太郎、小澤大作、杉木俊彦、石黒亮、徳田栄一、今野卓哉、小山哲秀、武内敏秀、古川良明、藤原敏道、和田圭司、小野寺理、永井義隆
- Organizer
  第15回日本臨床ストレス応答学会
- Data Source
  KAKENHI-PROJECT-19K07823
[Presentation] C9-ALS/FTDモデルショウジョウバエにおけるリピート関連非ATG翻訳の制御2019
- Author(s)
  上山盛夫, 石黒太郎, T. F. Gendron, 今野卓哉, 小山哲秀, 和田圭司, 石川欣也, 小野寺理, L. Petrucelli, 永井義隆
- Organizer
  第38回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-19K07823
[Presentation] ショウジョウバエモデルによるC9-ALS/FTDの病態解明2019
- Author(s)
  上山盛夫、石黒太郎、Tania F. Gendron、今野卓哉、小山哲秀、望月秀樹、和田圭司、石川欣也、小野寺理、Leonard Petrucelli、永井義隆
- Organizer
  医学系研究科-産業科学研究所懇話会
- Data Source
  KAKENHI-PROJECT-15K09331
[Presentation] Pathological roles of expanded repeat RNA and dipeptide repeat proteins in C9-ALS/FTD model fly2019
- Author(s)
  M. Ueyama, T. Ishiguro, T. Konno, A. Koyama, K. Ishikawa, K. Wada, O. Onodera, Y. Nagai,
- Organizer
  NEURO2019・第42回日本神経科学大会・第62回神経化学会大会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07823
[Presentation] Dissection of the pathogenic roles of expanded repeat RNA and dipeptide repeat proteins in C9-ALS/FTD model fly2018
- Author(s)
  M. Ueyama, T. Ishiguro, T. F. Gendron, T. Konno, A. Koyama, K. Ishikawa, K. Wada, O. Onodera, L. Petrucelli, Y. Nagai
- Organizer
  5th RNA Metabolism in Neurological Disease Conference
- Data Source
  KAKENHI-PROJECT-15K09331
[Presentation] ショウジョウバエモデルによるC9-ALS/FTDの病態解明2018
- Author(s)
  上山盛夫、石黒太郎、T. F. Gendron、今野卓哉、小山哲秀、望月秀樹、和田圭司、石川欣也、小野寺理、L. Petrucelli、永井義隆
- Organizer
  第37回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-15K09331
[Presentation] C9orf72関連ALS/FTDモデルショウジョウバエにおけるリピート関連非ATG翻訳の制御2018
- Author(s)
  上山盛夫
- Organizer
  第7回大阪大学神経難病フォーラム
- Invited
- Data Source
  KAKENHI-PROJECT-15K09331
[Presentation] C9orf72関連ALS/FTDモデルショウジョウバエの樹立とリピート関連非ATG翻訳の制御2018
- Author(s)
  上山盛夫、石黒太郎、今野卓哉、小山哲秀、和田圭司、石川欣也、小野寺理、永井義隆
- Organizer
  第16回神経科学研究会
- Invited
- Data Source
  KAKENHI-PROJECT-15K09331
[Presentation] Repeat associated non-ATG translation and its regulation in C9orf72-associated amyotrophic lateral sclerosis/frontotemporal dementia model fly2017
- Author(s)
  M. Ueyama, T. Ishiguro, T. Konno, A. Koyama, K. Wada, K. Ishikawa, O. Onodera, Y. Nagai
- Organizer
  第58回日本神経学会学術大会・第23回世界神経学会議
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09331
[Presentation] ショウジョウバエを用いた筋萎縮性側索硬化症/前頭側頭型認知症の病態形成メカニズムの解明2017
- Author(s)
  上山盛夫
- Organizer
  日本遺伝学会第89回大会
- Invited
- Data Source
  KAKENHI-PROJECT-15K09331
[Presentation] Repeat associated non-ATG translation in Drosophila C9ALS/FTD model2017
- Author(s)
  M. Ueyama, T. Ishiguro, T. Konno, A. Koyama, O. Onodera, K. Wada, Y. Nagai
- Organizer
  新学術・PACTALSジョイントミーティング
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09331
[Presentation] Regulation of repeat associated non-ATG translation in C9orf72-linked amyotrophic lateral sclerosis/frontotemporal dementia model flies2017
- Author(s)
  M. Ueyama, T. Ishiguro, N. Fujikake, T. Konno, A. Koyama, O. Onodera, K. Ishikawa, K. Wada, Y. Nagai
- Organizer
  第40回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-15K09331
[Presentation] C9ALS/FTDモデルショウジョウバエにおけるジペプチドリピートタンパク質の毒性2016
- Author(s)
  上山盛夫、石黒太郎、T. F. Gendron、藤掛伸宏、今野卓哉、小山哲秀、小野寺理、和田圭司、L. Petrucelli、永井義隆
- Organizer
  日本遺伝学会第88回大会
- Place of Presentation
  日本大学国際関係学部北口校舎(静岡県三島市)
- Year and Date
  2016-09-07
- Data Source
  KAKENHI-PROJECT-15K09331
[Presentation] Repeat associated non-ATG translation in Drosophila C9ALS/FTD model2016
- Author(s)
  M. Ueyama, T. Ishiguro, N. Fujikake, T. Konno, A. Koyama, O. Onodera, K. Wada, Y. Nagai
- Organizer
  第57回日本神経学会学術大会
- Place of Presentation
  神戸コンベンションセンター・神戸ポートピアホテル(兵庫県神戸市)
- Year and Date
  2016-05-18
- Data Source
  KAKENHI-PROJECT-15K09331
[Presentation] Toxicity of dipeptide repeat proteins in C9 ALS/FTD model fly2016
- Author(s)
  M. Ueyama, T. Ishiguro, T. F. Gendron, N. Fujikake, T. Konno, A. Koyama, O. Onodera, K. Ishikawa, K. Wada, L. Petrucelli, Y. Nagai
- Organizer
  11th Brain Research Conference
- Place of Presentation
  Paradise Point, San Diego (U.S.A.)
- Year and Date
  2016-11-10
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09331
[Presentation] Repeat associated non-ATG translation in Drosophila C9ALS/FTD model2016
- Author(s)
  M. Ueyama, T. Ishiguro, N. Fujikake, T. Konno, A. Koyama, O. Onodera, K. Wada, Y. Nagai
- Organizer
  第57回日本神経学会
- Place of Presentation
  神戸神戸コンベンションセンター・神戸ポートピアホテル
- Year and Date
  2016-05-18
- Data Source
  KAKENHI-PROJECT-15K09331
[Presentation] Establishment of a novel animal model of ALS/FTD expressing GGGGCC repeat RNA in Drosophila2015
- Author(s)
  M. Ueyama, T. Ishiguro, N. Fujikake, T. Konno, A. Koyama, O. Onodera, K. Ishikawa, K. Wada, Y. Nagai
- Organizer
  10th Brain Research Conference
- Place of Presentation
  Chicago (IL, U.S.A.) The Westin Chicago River North
- Year and Date
  2015-10-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09331
[Presentation] Establishment of a novel animal model of ALS and FTD expressing GGGGCC repeat RNA in Drosophila2015
- Author(s)
  M. Ueyama, T. Ishiguro, N. Fujikake, T. Konno, A. Koyama, O. Onodera, K. Ishikawa, K. Wada, Y. Nagai
- Organizer
  第38回日本神経科学大会
- Place of Presentation
  神戸神戸国際会議場・神戸国際展示場
- Year and Date
  2015-07-28
- Data Source
  KAKENHI-PROJECT-15K09331
[Presentation] G4C2リピートRNAを発現する新規ALS/FTDモデルショウジョウバエの樹立2015
- Author(s)
  上山盛夫、石黒太郎、藤掛伸宏、今野卓哉、小山哲秀、小野寺理、石川欽也、和田圭司、永井義隆
- Organizer
  日本遺伝学会第87回大会
- Place of Presentation
  仙台東北大学川内北キャンパス
- Year and Date
  2015-09-24
- Invited
- Data Source
  KAKENHI-PROJECT-15K09331
[Presentation] GGGGCCリピートRNAを発現する新規ALSモデルショウジョウバエの樹立と病態解析
- Author(s)
  上山盛夫、石黒太郎、藤掛伸宏、今野卓哉、小山哲秀、小野寺理、和田圭司、永井義隆
- Organizer
  日本遺伝学会第86回大会
- Place of Presentation
  長浜
- Year and Date
  2014-09-17 – 2014-09-19
- Data Source
  KAKENHI-PROJECT-25860733

1. Nagai Yoshitaka (60335354)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
2. 小澤大作 (60554524)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
3. YOSHIDA Hideki

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
4. 古川良明

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 藤掛伸宏

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 長野清一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 森康治

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 長谷川隆文

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

UEYAMA Morio 上山 盛夫

Research Projects

Research Products

Co-Researchers

リピート関連非AUG翻訳調節によるノンコーディングリピート病の病態制御Principal Investigator

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Elucidation of regulation mechanisms of LLPS leading to pathological protein aggregation in neurodegenerative diseases

Principal Investigator

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Elucidation of the mechanism of repeat-associated non-ATG translationPrincipal Investigator

Principal Investigator

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Elucidation of the pathogenic mechanisms of ALS/FTLD by identifying molecules related to repeat-associated non-ATG translationPrincipal Investigator

Principal Investigator

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Establishment of a novel animal model of ALS expressing GGGGCC repeat RNA in Drosophila, and analyses of its pathogenic mechanismsPrincipal Investigator

Principal Investigator

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Research Institution

[Journal Article] Dysregulation of stress granule dynamics by DCTN1 deficiency exacerbates TDP-43 pathology in Drosophila models of ALS/FTD.2024

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[Journal Article] Reconstitution of C9orf72 GGGGCC repeat-associated non-AUG translation with purified human translation factors.2023

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[Journal Article] Therapeutic reduction of GGGGCC repeat RNA levels by hnRNPA3 suppresses neurodegeneration in Drosophila models of C9orf72-linked ALS/FTD2023

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[Journal Article] Arylsulfatase A, a genetic modifier of Parkinson's disease, is an α-synuclein chaperone.2019

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[Journal Article] 神経変性疾患にかかわるリピート関連非ATG依存性翻訳と低複雑性ドメイン2019

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[Journal Article] E46K mutantα-synuclein is more degradation resistant and exhibits greater toxic effects than wild-typeα-synuclein in Drosophila models of Parkinson's disease.2019

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[Journal Article] Overexpressin of ter94, Drosophila VCP, improves motor neuron degeneration induced by knockdown of TBPH, Drosophila TDP-432018

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[Journal Article] NPM-hMLF1 fusion protein suppresses defects of a Drosophila FTLD model expressing the human FUS gene.2018

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[Journal Article] Hippo, Drosophila MST, is a novel modifier of motor neuron degeneration induced by knockdown of Caz, Drosophila FUS.2018

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[Journal Article] C9orf72連鎖性筋萎縮性側索硬化症・前頭側頭型認知症における病態メカニズム2018

Author(s)

Journal Title

UEYAMA Morio 上山盛夫

[Journal Article] 神経変性疾患への新しい視点 –プリオン仮説- D.タウ蛋白による前頭側頭葉変性症 (FTLD-Tau) 3.その他のFTLD (異常蛋白の視点から)2015