Rokudai Susumu 六代範

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ROKUDAI Susumu 六代範

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Researcher Number	20392334
Other IDs
Affiliation (Current)	2025: 群馬大学, 大学院医学系研究科, 講師
Affiliation (based on the past Project Information) *help	2019 – 2021: 群馬大学, 大学院医学系研究科, 講師 2009: 分子腫瘍学部, 研究員 2008 – 2009: 国立がんセンター(研究所及び東病院臨床開発センター), 分子腫瘍学部, 研究員 2007: 国立がんセンター研究所, 分子腫瘍学部, 研究員 2005 – 2006: National Cancer Center Research Institute, Molecular Oncology Division, Researcher, 分子腫瘍学部, 研究員 2004: 国立がんセンター(研究所), 分子腫瘍学部, 研究員
Review Section/Research Field	Principal Investigator Basic Section 50020:Tumor diagnostics and therapeutics-related Except Principal Investigator Basic Section 55040:Respiratory surgery-related / Biological pharmacy / Biological Sciences
Keywords	Principal Investigator Lung cancer / Syntaxin Binding Protein / TP63 / TP53 / Squamous cell carcinoma / Squamous Cell Carcinoma / Lung Cancer / がん遺伝子 / がん抑制遺伝子 / 白血病 … More / がん関連繊維芽細胞 / 扁平上皮癌 / 扁平上皮がん / 肺がん / p63 / p53 … More Except Principal Investigator histone acetyltransferase / MOZ / AML1 / HIPK2 / stem cells / transcription regulation / hematopoiesis / leukemia / PML / chromosome translocation / Leukemia / 白血病 / IGF1R / アジュバント療法 / 血行性転移 / vimentin(VIM) / 次世代シーケンス解析 / Vimentin / 転移 / 肺癌 / cell differeniation / nuclear body / タンパク質リン酸化 / 染色体転座 / hematopoietic stem cells / hematopietic stem cells / hisotone acetyltransferase / neutrophil / cell differentiation / M-CSFR / PU.1 / 幹細胞 / 転写制御 / タンパク質複合体 / 造血 Less

Investigation of the hematogenous metastasis mechanism in human lung cancer and development of new adjuvant therapy.
- Principal Investigator
  
  Ibe Takashi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55040:Respiratory surgery-related
- Research Institution
  独立行政法人国立病院機構高崎総合医療センター(臨床研究部)
  Gunma University
Novel Biomarker for Therapeutic Target in Lung squamous cell carcinomaPrincipal Investigator
- Principal Investigator
  
  Rokudai Susumu
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Gunma University
Functional study of leukemia-associated factor AML1
- Principal Investigator
  
  KITABAYASHI Issay
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East
AML1 complex as a molecular target for leukemia therapy
- Principal Investigator
  
  KITABAYASHI Issay
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  National Cancer Center Research Institute

All 2022 2021 2020 2019 2009 2007

All Journal Article Presentation Book Patent

[Book] High-Throughput RNA Interference Screen Targeting Synthetic-Lethal Gain-of-Function of Oncogenic Mutant TP53 in Triple-Negative Breast Cancer (Reviews).2020
- Author(s)
  Rokudai S.
- Publisher
  Springer Nature
- Data Source
  KAKENHI-PROJECT-19K07706
[Journal Article] KAT6A and ENL Form an Epigenetic Transcriptional Control Module to Drive Critical Leukemogenic Gene-Expression Programs2022
- Author(s)
  Yan F, Li J, Milosevic J, Petroni R, Liu S, Shi Z, Yuan S, Reynaga JM, Qi Y, Rico J, Yu S, Liu Y, Rokudai S, Palmisiano N, Meyer SE, Sung PJ, Wan L, Lan F, Garcia BA, Stanger BZ, Sykes DB, Blanco MA.
- Journal Title
  
  Cancer Discovery
  
  Volume: 12 Issue: 3 Pages: 792-811
- DOI
  10.1158/2159-8290.cd-20-1459
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07706
[Journal Article] KAT6A and ENL form an epigenetic transcriptional control module to drive critical leukemogenic gene-expression programs.2022
- Author(s)
  Yan F, Li J, Milosevic J, Petroni R, Liu S, Shi Z, Yuan S, Reynaga JM, Qi Y, Rico J, Yu S, Liu Y, Rokudai S, Palmisiano N, Meyer SE, Sung PJ, Wan L, Lan F, Garcia BA, Stanger BZ, Sykes DB, Blanco MA.
- Journal Title
  
  Cancer Discov.
  
  Volume: 12 Pages: 792-811
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K09300
[Journal Article] AKT3 is a novel regulator of cancer-associated fibroblasts in head and neck squamous cell carcinoma2021
- Author(s)
  Takahashi H, Rokudai S, Kawabata-Iwakawa R, Sakakura K, Oyama T, Nishiyama M, Chikamatsu K.
- Journal Title
  
  Cancers
  
  Volume: 13(6) Issue: 6 Pages: 1233-1233
- DOI
  10.3390/cancers13061233
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07706, KAKENHI-PROJECT-20K18243, KAKENHI-PROJECT-20H03834
[Journal Article] AKT3 is a key regulator of head and neck squamous cell carcinoma. Takahashi H, Rokudai S, Kawabata-Iwakawa R, Sakakura K, Oyama T, Nishiyama M, Chikamatsu K.2021
- Author(s)
  Takahashi H, Rokudai S, Kawabata-Iwakawa R, Sakakura K, Oyama T, Nishiyama M, Chikamatsu K.
- Journal Title
  
  Cancer Science
  
  Volume: - Issue: 6 Pages: 2325-2334
- DOI
  10.1111/cas.14911
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07706, KAKENHI-PROJECT-20K18243, KAKENHI-PROJECT-20H03834
[Journal Article] The ion channel TRPM7 regulates zinc depletion-induced MDMX degradation.2021
- Author(s)
  Wang H, Li B, Asha K, Pangilinan R, Thuraisamy A, Chopa H, Rokudai S, Prives C, Yu Y, Zhu Y.
- Journal Title
  
  J Biol Chem.
  
  Volume: 297 Pages: 101292-101292
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K09300
[Journal Article] The ion channel TRPM7 regulates zinc-depletion-induced MDMX degradation2021
- Author(s)
  Wang Herui、Li Bin、Asha Kulsum、Pangilinan Ryan L.、Thuraisamy Asha、Chopra Harman、Rokudai Susumu、Yu Yong、Prives Carol L.、Zhu Yan
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 297 Issue: 5 Pages: 101292-101292
- DOI
  10.1016/j.jbc.2021.101292
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07706
[Journal Article] Distinctive roles of syntaxin binding protein 4 and its action target, TP63, in lung squamous cell carcinoma: A theranostic study for the precision medicine2020
- Author(s)
  Bilguun EO, Kaira K, Kawabata-Iwakawa R, Rokudai S, Shimizu K, Yokobori T, Oyama T, Shirabe K, Nishiyama M.
- Journal Title
  
  BMC Cancer
  
  Volume: 20(1) Pages: 1-14
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07706
[Journal Article] Syntaxin binding proten 4 as a novel therapeutic target and an effective biomarker for better treatment selection in lung squamous cell carcinoma.2020
- Author(s)
  Bilguun EO, Kaira K, Kawabata-Iwakawa R, Rokudai S, Shimizu K, Yokobori T, Oyama T, Shirabe K, Nishiyama M.
- Journal Title
  
  Research Square, Review
  
  Volume: -
- DOI
  10.21203/rs.3.rs-39783/v1
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07706
[Journal Article] High-Throughput RNA Interference Screen Targeting Synthetic-Lethal Gain-of-Function of Oncogenic Mutant TP53 in Triple-Negative Breast Cancer.2020
- Author(s)
  Rokudai S.
- Journal Title
  
  Methods Mol Diol.
  
  Volume: 2108 Pages: 297-303
- DOI
  10.1007/978-1-0716-0247-8_25
- ISBN
  9781071602461, 9781071602478
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07706
[Journal Article] Carbonic anhydrase 9 expression is associated with poor prognosis, tumor proliferation, and radiosensitivity of thymic carcinomas.2019
- Author(s)
  Ohtaki Y, Shimizu K, Kawabata-Iwakawa R, Gombodorj N, Altan B, Rokudai S, Yamane A, Kaira K, Yokobori T, Nagashima T, Obayashi K, Nakazawa S, Iijima M, Kosaka T, Yajima T, Mogi A, Kuwano H, Shirabe K, Nishiyama M.
- Journal Title
  
  Oncotarget
  
  Volume: 10(13) Issue: 13 Pages: 1306-1319
- DOI
  10.18632/oncotarget.26657
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07706
[Journal Article] MOZ interacts with p53 to induce p21 expression and cell-cycle arrest.2009
- Author(s)
  Rokudai, et al.
- Journal Title
  
  J Biol Chem. 284
  
  Pages: 237-244
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013091
[Journal Article] MOZ interacts with p53 to induce p21 expression and cell-cycle arrest.2009
- Author(s)
  Rokudai S, Aikawa Y, Tagata Y, Tsuchida N, Taya Y, Kitabayashi I.
- Journal Title
  
  J Biol Chem. 284
  
  Pages: 237-244
- Data Source
  KAKENHI-PROJECT-17013091
[Journal Article] Mutations of the HIPK2 gene in acute myeloid leukemia and myelodysplastic syndrome impair AML1- and p53-mediated transcription.2007
- Author(s)
  Li XL, Arai Y, Harada H, Shima Y, Yoshida H, Rokudai S, Aikawa Y, Kimura A, Kitabayashi I
- Journal Title
  
  Oncogene (in press)
- Data Source
  KAKENHI-PROJECT-17013091
[Journal Article] Mutations of the HIPK2 gene in acute myeloid leukemia andmyelodysplastic syndrome impair AMLl-and p53-mediatedtranscription2007
- Author(s)
  Li XL, Arai Y, Haraa H, Shima Y, Yosbida H, Rokudai S, Aikawa Y, Kimura A, Kitabayasbi I.
- Journal Title
  
  Oncogene 26
  
  Pages: 7231-7239
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013091
[Journal Article] Mutations of the HIPK2 gene in acute myeloid leukemia and myelodysplastic syndrome impair AML1- and p53-mediated transcription.2007
- Author(s)
  Li XL, Arai Y, Harada H, Shima Y, Yoshida H, Rokudai S, Aikawa Y, Kimura A, Kitabayashi I.
- Journal Title
  
  Oncogene. 26
  
  Pages: 7231-7239
- Data Source
  KAKENHI-PROJECT-17013091
[Patent] Method for manufacturing peripheral nerve cells2021
- Inventor(s)
  高橋寛之、西山正彦、六代範、吉山伸司
- Industrial Property Rights Holder
  高橋寛之、西山正彦、六代範、吉山伸司
- Industrial Property Rights Type
  特許
- Filing Date
  2021
- Overseas
- Data Source
  KAKENHI-PROJECT-19K07706
[Patent] 抹消神経細胞の製造方法」2021
- Inventor(s)
  高橋寛之、西山正彦、六代範、吉山伸司
- Industrial Property Rights Holder
  高橋寛之、西山正彦、六代範、吉山伸司
- Industrial Property Rights Type
  特許
- Filing Date
  2021
- Acquisition Date
  2021
- Data Source
  KAKENHI-PROJECT-19K07706
[Patent] Method for manufacturing peripheral nerve cells.2020
- Inventor(s)
  西山正彦、六代範、吉山伸司
- Industrial Property Rights Holder
  西山正彦、六代範、吉山伸司
- Industrial Property Rights Type
  特許
- Filing Date
  2020
- Overseas
- Data Source
  KAKENHI-PROJECT-19K07706
[Patent] iPS抹消神経細胞の製造方法2019
- Inventor(s)
  西山正彦、六代範、吉山伸司
- Industrial Property Rights Holder
  西山正彦、六代範、吉山伸司
- Industrial Property Rights Type
  特許
- Filing Date
  2019
- Overseas
- Data Source
  KAKENHI-PROJECT-19K07706
[Presentation] 肺腺癌におけるアロマターゼの意義と細胞増殖能への影響2021
- Author(s)
  大和田竜司、矢澤理麻、調憲、六代範
- Organizer
  日本がん分子標的治療学会
- Data Source
  KAKENHI-PROJECT-19K07706
[Presentation] Novel Biomarker and Development of Squamous Cell Carcinoma for and Development of Therapeutic Target2019
- Author(s)
  Susumu Rokudai, Kyoichi Kaira, Daiki Tanaka, Eisuke Horigome, Michiru Fujieda, Yukihiro Otaka, Misaki Iijima, Yuji Kumakura, Kimihiro Shimizu, Tetsunari Oyama, Jun’ichi Tamura, Ken Shirabe, Carol Prives, Masahiko Nishiyama
- Organizer
  第57回日本癌治療学会学術集会
- Data Source
  KAKENHI-PROJECT-19K07706
[Presentation] 扁平上皮がんにおける新規p63結合分子STXBP4によるがん分子行的薬の探索2019
- Author(s)
  六代　範, 堀込瑛介, 田中大暉, 調憲, 桑野博行, 西山正彦
- Organizer
  第23回　日本がん分子標的治療学会
- Invited
- Data Source
  KAKENHI-PROJECT-19K07706
[Presentation] 扁平上皮がんにおける新規p63結合分子STXBP4による腫瘍悪性化とがん分子行的薬の探索2019
- Author(s)
  六代範, 田中大暉, 杉本明生、堀込瑛介、藤枝みちる、熊倉祐二、清水公裕、調憲, 西山正彦
- Organizer
  第78回　日本癌学会
- Data Source
  KAKENHI-PROJECT-19K07706

1. SHIMIZU Kimiko (00161414)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. KITABAYASHI Issay (20261175)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
3. YOSHIDA Hitoshi (30303548)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
4. Ibe Takashi (80826264)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 清水公裕 (90375535)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 河谷菜津子 (80805557)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 矢島俊樹 (20346852)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Rokudai Susumu 六代 範

ROKUDAI Susumu 六代 範

Research Projects

Research Products

Co-Researchers

Investigation of the hematogenous metastasis mechanism in human lung cancer and development of new adjuvant therapy.

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Novel Biomarker for Therapeutic Target in Lung squamous cell carcinomaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Functional study of leukemia-associated factor AML1

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

AML1 complex as a molecular target for leukemia therapy

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] High-Throughput RNA Interference Screen Targeting Synthetic-Lethal Gain-of-Function of Oncogenic Mutant TP53 in Triple-Negative Breast Cancer (Reviews).2020

Author(s)

Publisher

Data Source

[Journal Article] KAT6A and ENL Form an Epigenetic Transcriptional Control Module to Drive Critical Leukemogenic Gene-Expression Programs2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] KAT6A and ENL form an epigenetic transcriptional control module to drive critical leukemogenic gene-expression programs.2022

Author(s)

Journal Title

Data Source

[Journal Article] AKT3 is a novel regulator of cancer-associated fibroblasts in head and neck squamous cell carcinoma2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] AKT3 is a key regulator of head and neck squamous cell carcinoma. Takahashi H, Rokudai S, Kawabata-Iwakawa R, Sakakura K, Oyama T, Nishiyama M, Chikamatsu K.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The ion channel TRPM7 regulates zinc depletion-induced MDMX degradation.2021

Author(s)

Journal Title

Data Source

[Journal Article] The ion channel TRPM7 regulates zinc-depletion-induced MDMX degradation2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Distinctive roles of syntaxin binding protein 4 and its action target, TP63, in lung squamous cell carcinoma: A theranostic study for the precision medicine2020

Author(s)

Journal Title

Data Source

[Journal Article] Syntaxin binding proten 4 as a novel therapeutic target and an effective biomarker for better treatment selection in lung squamous cell carcinoma.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] High-Throughput RNA Interference Screen Targeting Synthetic-Lethal Gain-of-Function of Oncogenic Mutant TP53 in Triple-Negative Breast Cancer.2020

Author(s)

Journal Title

DOI

ISBN

Data Source

[Journal Article] Carbonic anhydrase 9 expression is associated with poor prognosis, tumor proliferation, and radiosensitivity of thymic carcinomas.2019

Author(s)

Journal Title

DOI

Rokudai Susumu 六代範

ROKUDAI Susumu 六代範