Yajima Toshiki 矢島俊樹

… Alternative Names

YAJIMA Toshiki 矢島俊樹

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Researcher Number	20346852
Other IDs
Affiliation (Current)	2023: 香川大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2022: 香川大学, 医学部, 教授 2019 – 2022: 群馬大学, 大学院医学系研究科, 准教授 2018: 群馬大学, 医学部附属病院, 講師 2016 – 2017: 群馬大学, 大学院医学系研究科, 助教 2005 – 2006: 群馬大学, 医学部, 助手 2003 – 2004: 九州大学, 生体防御医学研究所, 助手
Review Section/Research Field	Principal Investigator Bacteriology (including Mycology) / Immunology / General surgery / Basic Section 50020:Tumor diagnostics and therapeutics-related Except Principal Investigator Basic Section 55040:Respiratory surgery-related / Basic Section 50020:Tumor diagnostics and therapeutics-related / Basic Section 55020:Digestive surgery-related / Biological Sciences / Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields
Keywords	Principal Investigator 免疫学 / インターロイキン-15 / エフェクターCD8T細胞 / 二次免疫応答 / メモリーCD8T細胞 / Listeria monocytogenes / IL-15 / 細胞傷害活性 / IL-15トランスジェニックマウス / IL-15ノックアウトマウス … More / Listeria / 感染症 / 細菌 / Infectious disease / Immunology / Bacteria / 癌免疫アジュバント療法 / 免疫記憶 / 抗原特異的CD8T細胞 / 実験外科学 / 疲弊化CD8T細胞 / 免疫チェックポイント分子 / 腫瘍免疫 … More Except Principal Investigator 肺癌 / 難治癌 / CD30L / メモリーCD8T細胞 / セントラルメモリー / エフェクターメモリー / リステリア / CCR7 / リンパ組織 / 高悪性度肺神経内分泌腫瘍 / Stathmin 1 / PIP化合物 / タキサン系抗がん剤 / 神経内分泌腫瘍 / STMN1 / ピロールイミダゾームポリアミド / 小細胞癌 / スタスミン / 肺がん / 微小管 / パクリタキセル / 肺小細胞癌 / 大細胞性神経内分泌腫瘍 / Stathmin-1 / SCLC / LCNEC / 転移 / Vimentin / 次世代シーケンス解析 / vimentin(VIM) / 血行性転移 / アジュバント療法 / IGF1R / 免疫チェックポイント分子 / 疲弊化CD8T細胞 / 腫瘍免疫 / 免疫チェックポイント阻害剤 / 治療抵抗 / マウスモデル / FOXM1 / Chk1 / 小細胞肺癌 / ATR / MDR-1 / 抗がん剤耐性 / TGFBI / 免疫治療 / galectin 3阻害 / 臓器線維化 / がん免疫療法 / 消化器癌 / アミノ酸トランスポーター / IL-17産生γδ型Ｔ細胞 Less

癌細胞ならびに腫瘍免疫寛容の同時制御を目指した新規治療ツール開発
- Principal Investigator
  
  横堀武彦
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Gunma University
Galectin 3阻害剤創薬による難治疾患の病態解明と治療応用を目指した研究
- Principal Investigator
  
  調憲
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Gunma University
がん細胞特異的アミノ酸トランスポーターを標的とした新規複合的がん免疫療法の開発
- Principal Investigator
  
  酒井真
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Gunma University
Identification of novel immune check point molecules in exhausted CD8+ T cellsPrincipal Investigator
- Principal Investigator
  
  矢島俊樹
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Gunma University
IL-17産生γδ型Ｔ細胞を制御する新規癌免疫療法の創生を目指した基礎的研究
- Principal Investigator
  
  調憲
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields
- Research Institution
  Gunma University
マウスモデルを用いた免疫チェックポイント阻害剤の新たな治療抵抗メカニズムの解明
- Principal Investigator
  
  河谷菜津子
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55040:Respiratory surgery-related
- Research Institution
  Gunma University
Elucidation of anticancer drug resistance mechanism of lung cancer through FOXM1
- Principal Investigator
  
  大瀧容一
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55040:Respiratory surgery-related
- Research Institution
  Gunma University
Development of a new treatment for high-grade neuroendocrine carcinoma of the lung targeting Stathmin1
- Principal Investigator
  
  Shimizu Kimihiro
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Shinshu University
Investigation of the hematogenous metastasis mechanism in human lung cancer and development of new adjuvant therapy.
- Principal Investigator
  
  Ibe Takashi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55040:Respiratory surgery-related
- Research Institution
  独立行政法人国立病院機構高崎総合医療センター(臨床研究部)
  Gunma University
adjuvant therapyPrincipal Investigator
- Principal Investigator
  
  Yajima Toshiki
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  Gunma University
Role of Interleukin in CD8^+T Cell contraction during Primary InfectionPrincipal Investigator
- Principal Investigator
  
  YAJIMA Toshiki
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  Gunma University
抗原特異的メモリーT細胞サブセットの形成維持機構に関する研究
- Principal Investigator
  
  西村仁志
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kyushu University
自然免疫におけるMHCクラスIb拘束性CD8T細胞の役割Principal Investigator
- Principal Investigator
  
  矢島俊樹
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Kyushu University

All 2022 2021 2019 2007 2006 2005 2004 Other

All Journal Article Presentation

[Journal Article] Comprehensive expressional analysis of chemosensitivity‐related markers in large cell neuroendocrine carcinoma of the lung2021
- Author(s)
  Ohtaki Yoichi、Kaira Kyoichi、Yajima Toshiki、Erkhem‐Ochir Bilguun、Kawashima Osamu、Kamiyoshihara Mitsuhiro、Igai Hitoshi、Onozato Ryoichi、Ibe Takashi、Kosaka Takayuki、Nakazawa Seshiru、Nagashima Toshiteru、Oyama Tetsunari、Shirabe Ken
- Journal Title
  
  Thoracic Cancer
  
  Volume: 12 Pages: 2666-2679
- DOI
  10.1111/1759-7714.14102
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K09175
[Journal Article] Fas/FasL signaling is critical for the survival of exhausted antigen-specific CD8+ T cells during tumor immune response2019
- Author(s)
  Yajima T, Hoshino K, Muranushi R, Mogi A, Onozato R, Yamaki E, Kosaka T, Tanaka S, Shirabe K, Yoshikai Y and Kuwano H.
- Journal Title
  
  Molecular Immunology
  
  Volume: 107 Pages: 97-105
- DOI
  10.1016/j.molimm.2019.01.014
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-16H06496, KAKENHI-PROJECT-16K10450
[Journal Article] Enforced expression of Bcl-2 partially restores cell numbers but not functions of TCRgammadelta intestinal intraepithelial T lymphocytes in IL-15-deficient mice.2007
- Author(s)
  Nakazato K, Yamada H, Yajima T, et al.
- Journal Title
  
  J Immunol 178
  
  Pages: 757-764
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590438
[Journal Article] Enforced expression of Bcl-2 partially restores cell numbers but not functions of TCRgammadelta intestinal intraepithelial T lymphocytes in IL-15-deficient mice.2007
- Author(s)
  Nakazato K, Yamada H, Yajima T, Kagimoto Y, Kuwano H, Yoshikai Y.
- Journal Title
  
  J Immunol 178
  
  Pages: 757-764
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590438
[Journal Article] Role of interleukin 15 in colitis induced by dextran sulphate sodium in mice.2006
- Author(s)
  Yoshihara K, Yajima T, Kubo C, Yoshikai Y.
- Journal Title
  
  Gut 55
  
  Pages: 334-341
- Data Source
  KAKENHI-PROJECT-17590438
[Journal Article] Toll-Like receptors 2 and 4 are differentially involved in Fas dependent apoptosis in Peyer's patch and the liver at an early stage after bile duct ligation in mice.2006
- Author(s)
  Ogawa A, Tagawa T, Nishimura H, Yajima T, Abe T, Arai T, Taniguchi M, Takeda K, Akira S, Nimura Y, Yosikai Y.
- Journal Title
  
  Gut 55
  
  Pages: 105-113
- Data Source
  KAKENHI-PROJECT-17590438
[Journal Article] IL-15 regulates CD8+ T cell contraction during primary infection2006
- Author(s)
  Yajima T, et al.
- Journal Title
  
  J Immunol 176(1)
  
  Pages: 507-515
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590438
[Journal Article] Role of interleukin 15 in colitis induced by dextran sulphate sodium in mice.2006
- Author(s)
  Yoshihara K, Yajima T, Kubo C, Yoshikai Y.
- Journal Title
  
  Gut 55(3)
  
  Pages: 334-341
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590438
[Journal Article] Role of interleukin 15 in colitis induced by dextran sulphate sodium in mice2006
- Author(s)
  Yoshihara K, Yajima T, et al.
- Journal Title
  
  Gut 55(3)
  
  Pages: 334-341
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590438
[Journal Article] Impaired protection against Mycobacterium bovis bacillus Calmette-Guerin infection in IL-15-deficient mice.2006
- Author(s)
  Saito K, Yajima T, et al.
- Journal Title
  
  J Immunol 176(4):
  
  Pages: 2496-504
- Data Source
  KAKENHI-PROJECT-17590438
[Journal Article] Impaired protection against Mycobacterium bovis bacillus Calmette-Guerin infection in IL-15-deficient mice.2006
- Author(s)
  Saito K, Yajima T, Kumabe S, Doi T, Yamada H, Sad S, Shen H, Yoshikai Y.
- Journal Title
  
  J Immunol 176(4)
  
  Pages: 2496-2504
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590438
[Journal Article] Impaired protection against Mycobacterium bovis bacillus Calmette-Guerin infection in IL-15-deficient mice2006
- Author(s)
  Saito K, Yajima T, Kumabe S, Doi T, Yamada H, Sad S, Shen H, Yoshikai Y.
- Journal Title
  
  J Immunol 176
  
  Pages: 2496-2504
- Data Source
  KAKENHI-PROJECT-17590438
[Journal Article] Impaired protection against Mycobacterium bovis bacillus Calmette-Guerin infection in IL-15-deficient mice.2006
- Author(s)
  Saito K, Yajima T, et al.
- Journal Title
  
  J Immunol 176(4)
  
  Pages: 2496-2504
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590438
[Journal Article] A novel role of CD30/CD30L signaling in the generation of long-lived memory CD8^+T cell2005
- Author(s)
  Nishimura H, Yajima T, Muta H, Podack ER, Tani K, Yoshikai Y.
- Journal Title
  
  J Immunol 175
  
  Pages: 4627-4634
- Data Source
  KAKENHI-PROJECT-17590438
[Journal Article] A novel autoregulatory mechanism for transcriptional activation of the IL-15 gene by a nonsecretable isoform of IL-15 generated by alternative splicing.2005
- Author(s)
  Nishimura H, Fujimoto A, Tamura N, Yajima T, Wajjwaku W, Yoshikai Y.
- Journal Title
  
  FASEB J 19
  
  Pages: 19-28
- Data Source
  KAKENHI-PROJECT-17590438
[Journal Article] IL-15regulates CD8^+T cell contraction during primary infection2005
- Author(s)
  Yajima T., Yoshihara K., Nakazato K., Kumabe S., Koyasu S., Sad, S., Shen H., Kuwano H., Yoshikai Y.
- Journal Title
  
  J Immunol 174
  
  Pages: 3590-3597
- Data Source
  KAKENHI-PROJECT-17590438
[Journal Article] A Novel Role of IL-15 in Early Activation of Memory CD8+ CTL after Reinfection.2005
- Author(s)
  Yajima T., et al.
- Journal Title
  
  J.Immunol. 174(6)
  
  Pages: 3590-3597
- Data Source
  KAKENHI-PROJECT-15790224
[Journal Article] A novel role of IL-15 in early activation of memory CD8^+ CTL after reinfection.2005
- Author(s)
  Yajima T, Nishimura H, Sad S, Shen H, Kuwano H, Yoshikai Y.
- Journal Title
  
  J. Immunol 174(6)
  
  Pages: 3590-3597
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590438
[Journal Article] A novel role of CD30/CD30 ligand signaling in the generation of long-lived memory CD8^+T cells.2005
- Author(s)
  Nishimura H, Yajima T, Muta H, Podack ER, Tani K, Yoshikai Y.
- Journal Title
  
  J Immunol 175(7)
  
  Pages: 4627-4634
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590438
[Journal Article] Critical role of IL-15 in early activation of memory CD8^+ CTL after re-infection.2005
- Author(s)
  Yajima T., Nishimura H., Yoshikai Y.
- Journal Title
  
  J.Immunol (In press)
- Data Source
  KAKENHI-PROJECT-16043241
[Journal Article] Overexpression of Interleukin-15 increases susceptibility to lipopolysaccharide-induced liver injury in mice primed with Mycobacterium bovis bacillus Calmette-Guerin.2004
- Author(s)
  Yajima T., et al.
- Journal Title
  
  Infect Immun. 72(7)
  
  Pages: 3855-3862
- Data Source
  KAKENHI-PROJECT-15790224
[Journal Article] Overexpression of IL-15 increases susceptibility to lethal endotoxic shock in mice primed with Mycobacterium bovis BCG2004
- Author(s)
  Yajima T., Nishimura H., Yoshikai Y.
- Journal Title
  
  Infect.Immun. 72
  
  Pages: 3855-3862
- Data Source
  KAKENHI-PROJECT-16043241
[Journal Article] IL-15 regulates CD8^+T cell contraction during primary infection.
- Author(s)
  Yajima T, Yoshihara K, Nakazato K, Kumabe S, Koyasu S, Sad S, Shen H, Kuwano H, Yoshikai Y.
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590438
[Presentation] 抗 PD-1 抗体耐性メカニズムにおける疲弊化 CD8T 細胞での各免疫チェックポイント分子の役割2022
- Author(s)
  矢島　俊樹、村主遼、星野弘毅、吉川良平、大瀧容一、尾林海、中澤世識、河谷菜津子、矢澤友弘、塚越真梨子、調憲
- Organizer
  第122回日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-21K19518
[Presentation] 抗原特異的 CD8T 細胞の疲弊化誘導における各免疫チェックポイント分子の役割2022
- Author(s)
  村主　遼、矢島俊樹、星野弘毅、山中崇弘、萩原慶、塚越真梨子、石井範洋、渡辺亮、新木健一郎、播本憲史、調　憲
- Organizer
  第122回日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-21K19518
[Presentation] 腫瘍局所への放射線照射により活性化される、全身での抗腫瘍免疫応答に関する検討2021
- Author(s)
  栗山　健吾、矢島俊樹、山口亜梨紗、吉川良平、村主遼、須賀邦彦、星野弘毅、酒井真、佐野彰彦、小川博臣、宗田真、調憲、佐伯浩司
- Organizer
  第59回日本癌治療学会学術集会
- Data Source
  KAKENHI-PROJECT-21K19518
[Presentation] 抗原特異的CD8陽性T細胞の疲弊化誘導における各免疫チェックポイント分子の役割2021
- Author(s)
  村主　遼、矢島俊樹、星野弘毅、栗山健吾、塚越真梨子、山中崇弘、萩原慶、石井範洋、渡辺亮、新木健一郎、播本憲史、調　憲
- Organizer
  第59回日本癌治療学会学術集会
- Data Source
  KAKENHI-PROJECT-21K19518
[Presentation] 抗原特異的CD8Ｔ細胞誘導マウス腫瘍モデルを用いた動態解析2021
- Author(s)
  星野　弘毅、矢島俊樹、播本憲史、村主遼、萩原慶、山中崇弘、石井範洋、塚越真梨子、渡辺亮、新木健一郎、調　憲
- Organizer
  第59回日本癌治療学会学術集会
- Data Source
  KAKENHI-PROJECT-21K19518

1. 横堀武彦 (60420098)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
2. 調憲 (70264025)

# of Collaborated Projects: 5 results

# of Collaborated Products: 5 results
3. Shimizu Kimihiro (90375535)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. 中澤世識 (60791978)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
5. 大瀧容一 (00625402)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
6. 佐伯浩司 (80325448)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
7. YOSHIKAI Yasunobu (90158402)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. Ibe Takashi (80826264)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. 河谷菜津子 (80805557)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. 塚越真梨子 (60781317)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
11. 西村仁志 (00283440)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
12. 茂木晃 (10323362)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
13. 久保憲生 (10464744)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 堤荘一 (30323356)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 高坂貴行 (00507329)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
16. 東陽子 (30770002)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 宮崎達也 (70372349)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 尾林海 (70726249)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 永瀬浩喜 (90322073)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 渡部隆義 (60526060)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 六代範 (20392334)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 川端麗香 (90721928)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 解良恭一 (40400783)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 佐藤賢 (40396619)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. 高橋昭久 (60275336)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. 市川聡 (60333621)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. 酒井真 (70420099)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. 宗田真 (70507326)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. 吉開康信

# of Collaborated Projects: 0 results

# of Collaborated Products: 15 results

Yajima Toshiki 矢島 俊樹

YAJIMA Toshiki 矢島 俊樹

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Identification of novel immune check point molecules in exhausted CD8+ T cellsPrincipal Investigator

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adjuvant therapyPrincipal Investigator

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Role of Interleukin in CD8^+T Cell contraction during Primary InfectionPrincipal Investigator

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自然免疫におけるMHCクラスIb拘束性CD8T細胞の役割Principal Investigator

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[Journal Article] Comprehensive expressional analysis of chemosensitivity‐related markers in large cell neuroendocrine carcinoma of the lung2021

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[Journal Article] Fas/FasL signaling is critical for the survival of exhausted antigen-specific CD8+ T cells during tumor immune response2019

Yajima Toshiki 矢島俊樹

YAJIMA Toshiki 矢島俊樹