OBA Makoto 大庭誠

… Alternative Names

大庭誠オオバマコト

Less

Researcher Number	20396716
Other IDs
External Links
Affiliation (Current)	2025: 京都府立医科大学, 医学(系)研究科(研究院), 教授
Affiliation (based on the past Project Information) *help	2021 – 2022: 京都府立医科大学, 医学(系)研究科(研究院), 教授 2014 – 2017: 長崎大学, 医歯薬学総合研究科(薬学系), 准教授 2013: 長崎大学, 医歯(薬)学総合研究科, 准教授 2010 – 2011: 長崎大学, 大学院・医歯薬学総合研究科, 准教授 2010: The University of Tokyo, 医歯薬学総合研究科, 准教授 … More 2009: The University of Tokyo, 医学部付属病院, 特任助教 2009: 東京大学, 医学部附属病院, 特任助教 2008 – 2009: The University of Tokyo, 医学部・附属病院, 特任助教 2008: The University of Tokyo, 医学部・付属病院, 特任助教 2007: 東京大学, 医学部附属病院, 寄付講座教員 2007: The University of Tokyo, Hospital, Project Assistant Professor 2006: 東京大学, 医学部附属病院, 寄付講座教員(助教) 2005: 東京大学, 医学部附属病院, 寄附講座教員 Less
Review Section/Research Field	Principal Investigator Drug development chemistry / Biomedical engineering/Biomaterial science and engineering / General surgery / Biomedical engineering/Biological material science Except Principal Investigator Medium-sized Section 90:Biomedical engineering and related fields / Drug development chemistry / Radiation science / General surgery / Surgical dentistry
Keywords	Principal Investigator ドラッグデリバリーシステム / バイオテクノロジー / 薬学 / 有機化学 / コンフォメーション / 非天然型アミノ酸 / 遺伝子治療 / 膜透過機能 / ドラッグデリバリー / ヘリックス構造 … More / 細胞膜透過性 / フォルダマー / 膜透過性ペプチド / ペプチド / 刺激応答性材料 / 機能性ペプチド / ドラッグテリバリーシステム / 非ウイルス遺伝子ベクター / 血管外科学 / 血液脳関門 … More Except Principal Investigator ペプチド / 薬学 / 薬物動態 / 炎症性疾患 / ペプチド医薬 / 炎症 / ポリエチレングリコール / ダメージ関連分子パターン / ドラッグデリバリーシステム / 有機化学 / 細胞膜透過性 / ヘリックス構造 / 膜透過性ペプチド / 二次構造解析 / 非天然型アミノ酸 / がん / Survivin / survivin / 癌 / 内用放射線療法 / 放射線 / Circulation, Hypertension / Surgery / Nano-material / 循環器・高血圧 / 外科 / ナノ材料 / 再生骨 / スカフォール / トマテリアル / 塩基性線維芽細胞増殖因子 / スカフォールド / マテリアル / 血管新生 / 口腔外外科一般 Less

In situ PEGylation of extracellular DNA using functional peptides for anti-inflammatory therapy
- Principal Investigator
  
  Uchida Satoshi
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 90:Biomedical engineering and related fields
- Research Institution
  Tokyo Medical and Dental University
  Kyoto Prefectural University of Medicine
Development of cell penetrating peptide utilizing the charactaristic of disubstituted amino acid
- Principal Investigator
  
  Kato Takuma
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Drug development chemistry
- Research Institution
  Osaka University of Pharmaceutical Sciences
Development of fusion peptides of beta-hairpin peptides and survivin binding molecules as cancer-specific internal radiotherapeutic agents
- Principal Investigator
  
  FUCHIGAMI Takeshi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Radiation science
- Research Institution
  Nagasaki University
Development of cell-penetrating peptides and their application to DDS carriers(Fostering Joint International Research)Principal Investigator
- Principal Investigator
  
  OBA Makoto
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research)
- Research Field
  
  Drug development chemistry
- Research Institution
  Nagasaki University
Development of artificial peptides reversibly changing their secondary structures in response to reductive conditionPrincipal Investigator
- Principal Investigator
  
  OBA Makoto
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Biomedical engineering/Biomaterial science and engineering
- Research Institution
  Nagasaki University
Development of cell-penetrating peptides and their application as DDS carriersPrincipal Investigator
- Principal Investigator
  
  OBA Makoto
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Drug development chemistry
- Research Institution
  Nagasaki University
血液脳関門突破を目指したドラッグデリバリーシステムの創製Principal Investigator
- Principal Investigator
  
  大庭誠
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  The University of Tokyo
Development of gene therapy for vascular disease using multi-functional polymeric micellar gene vectorPrincipal Investigator
- Principal Investigator
  
  OBA Makoto
- Project Period (FY)
  2008 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  General surgery
- Research Institution
  Nagasaki University
  The University of Tokyo
Development of novel living material by regulation of angiogenesis
- Principal Investigator
  
  KOYAMA Hiroyuki
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Surgical dentistry
- Research Institution
  The University of Tokyo
Gene delivery using polyion complex micelle for the treatment of aortic aneurysm
- Principal Investigator
  
  MIYATA Tetsuro
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General surgery
- Research Institution
  The University of Tokyo

[Journal Article] An Amphipathic Structure of a Dipropylglycine-Containing Helical Peptide with Sufficient Length Enables Safe and Effective Intracellular siRNA Delivery2023
- Author(s)
  Makoto Oba, Mika Shibuya, Yuto Yamaberi, Hidetomo Yokoo, Satoshi Uchida, Atsushi Ueda, Masakazu Tanaka
- Journal Title
  
  Chemical and Pharmaceutical Bulletin
  
  Volume: 71 Issue: 3 Pages: 250-256
- DOI
  10.1248/cpb.c22-00852
- ISSN
  0009-2363, 1347-5223
- Year and Date
  2023-03-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H04962, KAKENHI-PROJECT-21K19923
[Journal Article] Cell-Penetrating Peptides: Emerging Tools for mRNA Delivery2022
- Author(s)
  H. Yokoo, M. Oba, S. Uchida
- Journal Title
  
  Pharmaceutics
  
  Volume: 14 Issue: 1 Pages: 78-78
- DOI
  10.3390/pharmaceutics14010078
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H04962, KAKENHI-PROJECT-21K19923
[Journal Article] A helix foldamer oligopeptide improves intracellular stability and prolongs protein expression of the delivered mRNA2021
- Author(s)
  S. Uchida, Y. Yamaberi, M. Tanaka, M. Oba
- Journal Title
  
  Nanoscale
  
  Volume: 13 Issue: 45 Pages: 18941-18946
- DOI
  10.1039/d1nr03600a
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H04962, KAKENHI-PROJECT-21K19923
[Journal Article] Secondary structures and cell-penetrating abilities of arginine-rich peptide foldamers2019
- Author(s)
  Oba Makoto、Nagano Yu、Kato Takuma、Tanaka Masakazu
- Journal Title
  
  Scientific Reports
  
  Volume: 9 Issue: 1 Pages: 1349-1349
- DOI
  10.1038/s41598-018-38063-8
- NAID
  120006987810
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H07269, KAKENHI-PROJECT-17H03998
[Journal Article] Left-handed helix of three-membered ring amino acid homopeptide interrupted by an N-H...ethereal O type hydrogen bond2018
- Author(s)
  Y. Koba, A. Ueda, M. Oba, M. Doi, T. Kato, Y. Demizu, M. Tanaka*
- Journal Title
  
  Org. Lett.
  
  Volume: 20 Issue: 24 Pages: 7830-7834
- DOI
  10.1021/acs.orglett.8b03331
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-18K14870, KAKENHI-PROJECT-17H03998, KAKENHI-PROJECT-17H07269, KAKENHI-PROJECT-16K18847
[Journal Article] Cell-Penetrating Peptides Using Cyclic α,α-Disubstituted α-Amino Acids with Basic Functional Groups2018
- Author(s)
  Kato Takuma、Oba Makoto、Nishida Koyo、Tanaka Masakazu
- Journal Title
  
  ACS Biomaterials Science & Engineering
  
  Volume: 4 Issue: 4 Pages: 1368-1376
- DOI
  10.1021/acsbiomaterials.8b00180
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H03998, KAKENHI-PROJECT-17H07269
[Journal Article] Enhanced and Prolonged Cell-Penetrating Abilities of Arginine-Rich Peptides by Introducing Cyclic α,α-Disubstituted α-Amino Acids with Stapling2017
- Author(s)
  Oba Makoto、Kunitake Masayuki、Kato Takuma、Ueda Atsushi、Tanaka Masakazu
- Journal Title
  
  Bioconjugate Chemistry
  
  Volume: 28 Issue: 7 Pages: 1801-1806
- DOI
  10.1021/acs.bioconjchem.7b00190
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K18847, KAKENHI-PROJECT-17H07269
[Journal Article] Development of radioiodinated acridine derivatives for in vivo imaging of prion deposits in the brain.2017
- Author(s)
  Kawasaki M, Fuchigami T, Kobashi N, Nakagaki T, Sano K, Atarashi R, Yoshida S, Haratake M, Nishida N, Nakayama M
- Journal Title
  
  Bioorganic & Medicinal Chemistry.
  
  Volume: 25 Issue: 3 Pages: 1085-1093
- DOI
  10.1016/j.bmc.2016.12.020
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16H05392, KAKENHI-PROJECT-15K09895, KAKENHI-PROJECT-16K15585, KAKENHI-PROJECT-15KK0348, KAKENHI-PROJECT-15H04269
[Journal Article] A Cell-Penetrating Peptide with a Guanidinylethyl Amine Structure Directed to Gene Delivery2016
- Author(s)
  M. Oba, T. Kato, K. Furukawa, M. Tanaka,
- Journal Title
  
  Scientific Reports
  
  Volume: 6 Issue: 1 Pages: 19913-19913
- DOI
  10.1038/srep19913
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15J05945, KAKENHI-PROJECT-25713008
[Journal Article] Cyclic a,a-disubstituted a-amino acids with menthone in their side chains through an acetal moiety and helical structures of their peptides2016
- Author(s)
  Kaori Furukawa, Makoto Oba, George Ouma Opiyo, Mitsunobu Doi, Masakazu Tanaka
- Journal Title
  
  European Journal of Organic Chemistry
  
  Volume: 16 Issue: 17 Pages: 2988-2998
- DOI
  10.1002/ejoc.201600241
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25713008
[Journal Article] Conformational studies on peptides having dipropylglycine (Dpg) or 1-aminocycloheptanecarboxylic acid (Ac7c) within the sequence of L-leucine (Leu) residues2016
- Author(s)
  M. Oba, H. Nonaka, M. Doi, M. Tanaka
- Journal Title
  
  Biopolymers (Pept.Sci.)
  
  Volume: 106 Issue: 2 Pages: 210-218
- DOI
  10.1002/bip.22810
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PUBLICLY-26105745, KAKENHI-PROJECT-25560226, KAKENHI-PROJECT-25713008
[Journal Article] Development of a Cell-penetrating Peptide that Exhibits Responsive Changes in its Secondary Structure in the Cellular Environment2016
- Author(s)
  H. Yamashita, T. Kato, M. Oba, T. Misawa, T. Hattori, N. Ohoka, M. Tanaka, M. Naito, M. Kurihara, Y. Demizu
- Journal Title
  
  Scientific Reports
  
  Volume: 6 Issue: 1 Pages: 33003-33003
- DOI
  10.1038/srep33003
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15J05945, KAKENHI-PROJECT-25713008, KAKENHI-PROJECT-26460169
[Journal Article] Plasmid DNA delivery by arginine-rich cell-penetrating peptides containing unnatural amino acids2016
- Author(s)
  T. Kato, H. Yamashita, T. Misawa, K. Nishida, M. Kurihara, M. Tanaka, Y. Demizu, M. Oba
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 24 Issue: 12 Pages: 2681-2687
- DOI
  10.1016/j.bmc.2016.04.031
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15J05945, KAKENHI-PROJECT-25713008, KAKENHI-PROJECT-16K08340, KAKENHI-PROJECT-26460169
[Journal Article] Plasmid DNA delivery using fluorescein-labeled arginine-rich peptides2015
- Author(s)
  M. Oba,* Y. Demizu, H. Yamashita, M. Kurihara, M. Tanaka
- Journal Title
  
  Bioorg. Med. Chem.
  
  Volume: 23 Issue: 15 Pages: 4911-4918
- DOI
  10.1016/j.bmc.2015.05.025
- NAID
  120006986986
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26460169, KAKENHI-PROJECT-25713008
[Journal Article] Amphipathic short helix-stabilized peptides with cell-membrane penetrating ability2014
- Author(s)
  Hiroko Yamashita, Yosuke Demizu, Takuji Shoda, Yukiko Sato, Makoto Oba, Masakazu Tanaka, Masaaki Kurihara
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 22 Issue: 8 Pages: 2403-2408
- DOI
  10.1016/j.bmc.2014.03.005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25713008, KAKENHI-PROJECT-26460169, KAKENHI-PROJECT-26860085
[Journal Article] Conformational studies on peptides having chiral five-membered ring amino acid with two azido or triazole functional groups within the sequence of Aib residues2014
- Author(s)
  Makoto Oba, Naomi Kawabe, Hiroomi Takazaki, Yosuke Demizu, Mitsunobu Doi, Masaaki Kurihara, Hiroshi Suemune, Masakazu Tanaka
- Journal Title
  
  Tetrahedron
  
  Volume: 70 Issue: 46 Pages: 8900-8907
- DOI
  10.1016/j.tet.2014.09.086
- NAID
  120006987171
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25410096, KAKENHI-PROJECT-25713008, KAKENHI-PUBLICLY-26105745, KAKENHI-PROJECT-26460169
[Journal Article] Cell-penetrating helical peptides having L-arginines and five-membered ring α,α-disubstituted α-amino acids.2014
- Author(s)
  Takuma Kato, Makoto Oba, Koyo Nishida, Masakazu Tanaka
- Journal Title
  
  Bioconjugate Chemistry
  
  Volume: 25 Issue: 10 Pages: 1761-1768
- DOI
  10.1021/bc5003949
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25713008
[Journal Article] Helical Peptide-Foldamers Having a Chiral Five-Membered Ring Amino Acid with Two Azido Functional Groups2014
- Author(s)
  Makoto Oba, Hiroomi Takazaki, Naomi Kawabe, Mitsunobu Doi, Yosuke Demizu, Masaaki Kurihara, Hiromu Kawakubo, Masanobu Nagano, Hiroshi Suemune, and Masakazu Tanaka
- Journal Title
  
  The Journal of Organic Chemistry
  
  Volume: 79 Issue: 19 Pages: 9125-9140
- DOI
  10.1021/jo501493x
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-13J03534, KAKENHI-PROJECT-25410096, KAKENHI-PROJECT-25713008, KAKENHI-PUBLICLY-26105745, KAKENHI-PROJECT-26460169
[Journal Article] Protein transfection study using multicellular tumor spheroids of human hepatoma Huh-7 cells2013
- Author(s)
  Takuma Kato, Masakazu Tanaka, Makoto Oba
- Journal Title
  
  PLoS ONE
  
  Volume: 8 Issue: 12 Pages: e82876-e82876
- DOI
  10.1371/journal.pone.0082876
- NAID
  120006986750
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25560226, KAKENHI-PROJECT-25713008
[Journal Article] Helical Oligomers with a Changeable Chiral Acetal Moiety2013
- Author(s)
  M. Oba
- Journal Title
  
  Eur. J. Org. Chem.
  
  Volume: - Issue: 34 Pages: 7679-7682
- DOI
  10.1002/ejoc.201301450
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-24105525, KAKENHI-PROJECT-25410096, KAKENHI-PROJECT-25713008
[Journal Article] Antaiangiogenic gene therapy of experimental pancreatic tumor by sFlt-1 plasmid DNA carried by RGD-modified crosslinked polyplex micelles2011
- Author(s)
  Y.Vachutinsky, M.Oba, K.Miyata, S.Hiki, M.R.Kano, N.Nishiyama, H.Koyama, K.Miyazono, K.Kataoka
- Journal Title
  
  Journal of Controlled Release
  
  Volume: 149(1) Pages: 51-57
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20689024
[Journal Article] Polylex micelles prepared from ω-cholesteryl PEG-polycation block copolymers for systemic gene delivery2011
- Author(s)
  M.Oba, K.Miyata, K.Osada, R.J.Christie, M.Sanjoh, W.Li, S.Fukushima, T.Ishii, M.R.Kano, N.Nishiyama, H.Koyama, K.Kataoka
- Journal Title
  
  Biomaterials
  
  Volume: 32(2) Issue: 2 Pages: 652-663
- DOI
  10.1016/j.biomaterials.2010.09.022
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20689024, KAKENHI-PROJECT-21659299, KAKENHI-PROJECT-22390244, KAKENHI-PROJECT-22750098
[Journal Article] Antiangiogenic gene therapy of experimental pancreatic tumor by sFlt-1 plasmid DNA carried by RGD-modified crosslinked polyplex micelles2011
- Author(s)
  Y. Vachutinsky, M. Oba, K. Miyata, S. Hiki, M. R. Kano, N. Nishiyama, H. Koyama, K. Miyazono, K. Kataoka
- Journal Title
  
  J. Control. Release
  
  Volume: 149(1) Pages: 51-57
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20689024
[Journal Article] Effect of integrin targeting and PEG shielding on polyplex micelle internalization studied by live-cell imaging2011
- Author(s)
  F. M. Konig, Y. Vachutinsky, M. Oba, K. Miyata, N. Nishiyama, K. Kataoka, C. Brauchle, N. Ruthardt
- Journal Title
  
  J. Control. Release
  
  Volume: 156(3) Pages: 364-373
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20689024
[Journal Article] Polyplex micelles prepared fromω-cholesteryl PEG-polycation block copolymers for systemic gene delivery2011
- Author(s)
  M. Oba, K. Miyata, K. Osada, R. J. Christie, M. Sanjoh, W. Li, S. Fukushima, T. Ishii, M. R. Kano, N. Nishiyama, H. Koyama, K. Kataoka
- Journal Title
  
  Biomaterials
  
  Volume: 32(2) Pages: 652-663
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20689024
[Journal Article] Effect of integrin targeting and PEG shielding on polyplex micelle internalization studied by live-cell imaging2011
- Author(s)
  F.M.Konig, Y.Vachutinsky, M.Oba, K.Miyata, N.Nishiyama, K.Kataoka, C.Brauchle, N.Ruthardt
- Journal Title
  
  Journal of Controlled Release
  
  Volume: 151(2) Issue: 3 Pages: 104-109
- DOI
  10.1016/j.jconrel.2011.08.003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20689024, KAKENHI-PROJECT-21659299, KAKENHI-PROJECT-23350049, KAKENHI-PROJECT-23390009
[Journal Article] pDNA/ poly(L-lysine) polyplexes functionalized with a pH-sensitive charge-conversional poly(aspartamide) derivative for controlled gene delivery to human umbilical vein endothelial cells2010
- Author(s)
  M. Sanjoh, S. Hiki, Y. Lee, M. Oba, K. Miyata, T. Ishii, K. Kataoka
- Journal Title
  
  Macromol. Rapid Comm
  
  Volume: 31(13) Pages: 1181-1186
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20689024
[Journal Article] Enhanced transfection with silica-coated polyplexes loading plasmid DNA2010
- Author(s)
  Kanjiro Miyata, Noha Gouda, Hiroyasu Takemoto, Makoto Oba, Yan Lee, Hiroyuki Koyama, Yuichi Yamasaki, Keiji Itaka, Nobuhiro Nishiyama, Kazunori Kataoka
- Journal Title
  
  Biomaterials 31(17)
  
  Pages: 4764-4770
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20689024
[Journal Article] Antiangiogenic gene therapy of solid tumor by systemic injection of polyplex micelles loading plasmid DNA encoding soluble Flt-12010
- Author(s)
  Makoto Oba, Yelena Vachutinsky, Kanjiro Miyata, Mitsunobu R.Kano, Sorato Ikeda, Nobuhiro Nishiyama, Keiji Itaka, Kohei Miyazono, Hiroyuki Koyama, Kazunori Kataoka
- Journal Title
  
  Mol.Pharmaceutics 7(2)
  
  Pages: 501-509
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20689024
[Journal Article] Introduction of stearoyl moieties into a biocompatible cationic polyaspartamide derivative, PAsp(DET), with endosomal escaping function for enhanced siRNA-mediated gene knockdown2010
- Author(s)
  H.J.Kim, A.Ishii, K.Miyata, Y.Lee, S.Wu, M.Oba, N.Nishiyama, K.Kataoka
- Journal Title
  
  Journal of Controlled Release
  
  Volume: 145(2) Pages: 141-148
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20689024
[Journal Article] pDNA/poly(L-lysine)polyplexes functionalized with a pH-sensitive charge-conversional poly(aspartamide)derivative for controlled gene delivery to human umbilical vein endothelial cells2010
- Author(s)
  M.Sanjoh, M.Oba, et al
- Journal Title
  
  Macromolecular Rapid Communication (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20650065
[Journal Article] Introduction of stearoyl moieties into a biocompatible cationic polyaspartamide derivative, PAsp(DET), with endosomal escaping function for enhanced siRNA-mediated gene knockdown2010
- Author(s)
  H. J. Kim, A. Ishii, K. Miyata, Y. Lee, S. Wu, M. Oba, N. Nishiyama, K. Kataoka
- Journal Title
  
  J. Control. Release
  
  Volume: 145(2) Pages: 141-148
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20689024
[Journal Article] Anti-angiogenic gene therapy of solid tumor by systemic injection Of polyplex micelles loading plasmid DNA encoding soluble Flt-12010
- Author(s)
  M.Oba, et al
- Journal Title
  
  Molecular Pharmaceutics 7(2)
  
  Pages: 501-509
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20689024
[Journal Article] Polyion complex stability and gene silencing efficiency with a siRNA-grafted polymer delivery system2010
- Author(s)
  H. Takemoto, A. Ishii, K. Miyata, M. Nakanishi, M. Oba, T. Ishii, Y. Yamasaki, N. Nishiyama, K. Kataoka
- Journal Title
  
  Biomaterials
  
  Volume: 31(31) Pages: 8097-8105
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20689024
[Journal Article] siRNA-based therapy of glomerulonephritis2010
- Author(s)
  H.Shimizu, Y.Hori, S.Kaname, K.Yamada, N.Nishiyama, S.Matsumoto, K.Miyata, M.Oba, et al
- Journal Title
  
  Journal of the American Society of Nephrology 21
  
  Pages: 622-633
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20689024
[Journal Article] Antiangiogenic gene therapy of solid tumor by systemic injection of polyplex micelles loading plasmid DNA encoding soluble Flt-12010
- Author(s)
  M. Oba, Y. Vachutinsky, K. Miyata, M. R. Kano, S. Ikeda, N. Nishiyama, K. Itaka, K. Miyazono, H. Koyama, K. Kataoka
- Journal Title
  
  Mol. Pharmaceutics
  
  Volume: 7(2) Pages: 501-509
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20689024
[Journal Article] Anti-angiogenic gene therapy of solid tumor by systemic injection of polyplex micelles loading plasmid DNA encoding soluble Flt-12010
- Author(s)
  M.Oba, et al
- Journal Title
  
  Molecular Pharmaceutics 7(2)
  
  Pages: 501-509
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20650065
[Journal Article] Antiangiogenic gene therapy of solid tumor by systemic injection of polyplex micell es loading plasmid DNA encoding soluble flt-12010
- Author(s)
  Oba M, Koyama H, Kataoka K, et al.
- Journal Title
  
  Mol Pharm. 7 (2)
  
  Pages: 201-509
- Data Source
  KAKENHI-PROJECT-19390510
[Journal Article] Enhanced transfection eith silica-coated polyplexes loading plasmid DNA2010
- Author(s)
  K.Miyata, M.Oba, et al
- Journal Title
  
  Biomaterials 31(17)
  
  Pages: 4764-4770
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20650065
[Journal Article] pDNA/poly(L-lysine) polyplexes functionalized with a pH-sensitive charge-conversional poly(aspartamide) derivative for controlled gene delivery to human umbilical vein endothelial cells2010
- Author(s)
  M.Sanjoh, S.Hiki, Y.Lee, M.Oba, K.Miyata, T.Ishii, K.Kataoka
- Journal Title
  
  Macromolecular Rapid Communications
  
  Volume: 31(13) Pages: 1181-1186
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20689024
[Journal Article] Antiangiogenic gene therapy of solid tumor by systemic injection of polyplex micelles loading plasmid DNA encoding soluble Flt-12010
- Author(s)
  M.Oba, Y.Vachutinsky, K.Miyata, M.R.Kano, S.Ikeda, N.Nishiyama, K.Itaka, K.Miyazono, H.Koyama, K.Kataoka
- Journal Title
  
  Molecular Pharmaceutics
  
  Volume: 7(2) Pages: 501-509
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20689024
[Journal Article] Enhanced transfection with silica-coated polyplexes loading plasmid DNA2010
- Author(s)
  K. Miyata, N. Gouda, H. Takemoto, M. Oba, Y. Lee, H. Koyama, Y. Yamasaki, K. Itaka, N. Nishiyama, K. Kataoka
- Journal Title
  
  Biomaterials
  
  Volume: 31(17) Pages: 4764-4770
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20689024
[Journal Article] Antiangiogenic gene therapy of experimental pancreatic tumor by sFlt-1 plasmid DNA carried by RGD-modified crosslinked micelles2010
- Author(s)
  Y.Vachutinsky, M.Oba, et al
- Journal Title
  
  Journal of Controlled Release (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20689024
[Journal Article] Enhanced percolation and gene expression in tumor hypoxia by PEGylated polyplex micelles2009
- Author(s)
  M. Han, M. Oba, N. Nishiyama, M. R. Kano, S. Kizaka-Kondoh, K. Kataoka
- Journal Title
  
  Mol. Ther
  
  Volume: 17(8) Pages: 1404-1410
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20689024
[Journal Article] Environment-responsive block copolymer micelles with a disul fide cross-linked core for enhanced si RNA delivery2009
- Author(s)
  Matsumoto S, Oba M, Koyama H, et al.
- Journal Title
  
  Biomacromol ecules 10
  
  Pages: 119-127
- Data Source
  KAKENHI-PROJECT-19390510
[Journal Article] Environmental-responsive block copolymer micelles with a disulfide cross-linked core for enhanced siRNA delivery2009
- Author(s)
  S. Matsumoto, R. J. Christie, N. Nishiyama, K. Miyata, A. Ishii, M. Oba, H. Koyama, Y. Yamasaki, K. Kataoka
- Journal Title
  
  Biomacromolecules
  
  Volume: 10(1) Pages: 119-127
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20689024
[Journal Article] Enhanced percolation and gene expression in tumor hypoxia by PEGylated polyplex micelles2009
- Author(s)
  M.Han, M.Oba, et al
- Journal Title
  
  Molecular Therapy 17(8)
  
  Pages: 1404-1410
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20689024
[Journal Article] Environmental-responsive block copolymer micelles with a disulfide cross-linked core for enhanced siRNA delivery2009
- Author(s)
  S.Matsumoto, R.J.Christie, N.Nishiyama, K.Miyata, A.Ishii, M.Oba, et al
- Journal Title
  
  Biomacromolecules 10(1)
  
  Pages: 119-127
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20689024
[Journal Article] Enhanced percolation and gene expression in tumor hypoxia by PEGylated polyplex micelles2009
- Author(s)
  Muri Han, Makoto Oba, Nobuhiro Nishiyama, Mitsunobu R.Kano, Shinae Kizaka-Kondoh, Kazunori Kataoka
- Journal Title
  
  Mol.Ther 17(8)
  
  Pages: 1404-1410
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20689024
[Journal Article] Controlled delivery of bFGF remodeled vascular network in muscle flap and increased perfusion capacity viaminor pedicle2008
- Author(s)
  Yasuda Y., Koyama H., Oba M, et al.
- Journal Title
  
  Journal of Surgical Research 147 (1)
  
  Pages: 132-7
- Data Source
  KAKENHI-PROJECT-19390510
[Journal Article] Controlled delivery of bFGF remodeled vascular network in muscle flap and increased perfusion capacity via minor pedicle.2008
- Author(s)
  Yasuda Y. Koyama H. Oba M. et al
- Journal Title
  
  Journal of Surgical Research 147
  
  Pages: 5163-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390510
[Journal Article] Polyplex micelles with cyclic RGD peptide ligands and disulfide crosslinks directing to the enhanced transfetion via controlled intracellular trafficking2008
- Author(s)
  Makoto Oba, Kazuhiro Aoyagai, Kanjiro Miyata, Yu Matsumoto, Keiji Itaka, Nobuhiro Nishiyama, Yuichi Yamasaki, Hiroyuki Koyama, Kazunori Kataoka
- Journal Title
  
  Mol.Pharmaceutics 5(6)
  
  Pages: 1080-1092
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20689024
[Journal Article] Controlled delivery of bFGF remodeled vascular network in muscle flap and increased perfusion capacity via minor pedicle2008
- Author(s)
  Y. Yasuda, M. Oba, et al
- Journal Title
  
  Journal of Surgical Research 147(1)
  
  Pages: 132-137
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20650065
[Journal Article] Charge-conversion ternary polyplex with endosome disruption moiety: a to chnique for efficient and safe gene delivery.2008
- Author(s)
  Lee Y. Oba M. Koyama H. et at
- Journal Title
  
  Angewandte Chemie. International Ed. In English. 47
  
  Pages: 5163-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390510
[Journal Article] Polyplexes from poly (aspartamide) bearing 1, 2-diaminoet hane si de chains induce pH-selective, endosomal membrane dest abilization with amplified transfection and negligible cytotoxicity2008
- Author(s)
  Miyata K., Oba M., Koyama H, et al.
- Journal Title
  
  Journal of the American Chemical Society 130 (48)
  
  Pages: 16287-94
- Data Source
  KAKENHI-PROJECT-19390510
[Journal Article] Polyplex micelles from triblock copolymers composed of tandemly aligned segments with biocompatible, endosomat escaping, and DNA condensing functions for systemic gene delivery to pancreatic tumor tissue.2008
- Author(s)
  Miyata K. Oba M. Koyama H. et al
- Journal Title
  
  Pharmaceutical Research. 25
  
  Pages: 2924-36
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390510
[Journal Article] Polyplex micelles with cyclec RGD ligands and disulfide crosslinks directing to the enhanced transfection via controlled intracellular trafficking2008
- Author(s)
  M. Oba, et al
- Journal Title
  
  Molecular Pharmaceutics 5(6)
  
  Pages: 1080-1092
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20650065
[Journal Article] Polyplex micelles from triblock copolymers composed of tandemly aligned segments with biocompatible, endosomal escaping, and DNA-condensing functions for systemic gene delivery to pancreatic tumor tissue2008
- Author(s)
  K. Miyata, M. Oba, et.al.
- Journal Title
  
  Pharmaceutical Research 25(12)
  
  Pages: 2924-2936
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20689024
[Journal Article] Polyplexes from poly(aspartamide) bearing 1, 2-diaminoethane side chains induce pH-selective, endosomal membrane destabilization with amplified transfection and negligible cytotoxicity2008
- Author(s)
  Kanjiro Miyata, Makoto Oba, Masataka Nakanishi, Shigeto Fukushima, Yuichi Yamasaki, Hiroyuki Koyama, Nobuhiro Nishiyama, Kazunori Kataoka
- Journal Title
  
  J.Am.Chem.Soc 130(48)
  
  Pages: 16287-16294
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20689024
[Journal Article] Polyplex micelles with cyclic RGD peptide ligands and disulfide crosslinks directing to the enhanced transfection via controlled intracellular trafficking2008
- Author(s)
  M. Oba, et.al.
- Journal Title
  
  Molecular Pharmaceutics 5(6)
  
  Pages: 1080-1092
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20689024
[Journal Article] Polyplex micelles from triblock copolymers composed of tandemly aligned segments with biocompatible, endosomal escaping, and DNA-condensing functions for systemic gene delivery to pancreatic tumor tissue2008
- Author(s)
  K. Miyata, M. Oba, M. R. Kano, S. Fukushima, Y. Vachutinsky, M. Han, H. Koyama, K. Miyazono, N. Nishiyama, K. Kataoka
- Journal Title
  
  Pharm. Res
  
  Volume: 25(12) Pages: 2924-2936
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20689024
[Journal Article] Polyplex micelles fromtri block copolymers composed of tandemly aligned segment with biocompatible, endosomal escaping, and DNA condensing functions for systemic gene delivery to pancreatic tumor tissue2008
- Author(s)
  Miyata K., Oba M., Koyama H, et al.
- Journal Title
  
  Pharmaceutical Research 25 (12)
  
  Pages: 2924-36
- Data Source
  KAKENHI-PROJECT-19390510
[Journal Article] PEG-det achable polyplex micelles based on disulfide-linked block catiomers as bior esponsive nonviral gene vectors2008
- Author(s)
  Takae S., Oba M., Koyama H, et al.
- Journal Title
  
  Journal of the American Chemical Society 130 (18)
  
  Pages: 6001-9
- Data Source
  KAKENHI-PROJECT-19390510
[Journal Article] Controlled Delivery of bFGF to Recipient Bed Enhances Vascularization and Viability of Ischemic Skin Flap2008
- Author(s)
  Fujiwara Y, Oba M, Koyama H, et. al.
- Journal Title
  
  Wound Repair and Regeneration (in press)
- NAID
  10031181445
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390510
[Journal Article] Charge-conversional ternary polyplex with endosome disruption moiety: a new paradigm for the efficient and safe gene delivery2008
- Author(s)
  Y. Lee, M. Oba, et al
- Journal Title
  
  Angewandte Chemie International Eddition 47(28)
  
  Pages: 5163-5166
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20650065
[Journal Article] Polyplex micelles with cyclic RGD peptide ligands and disulfide crosslinks directing to the enhanced transfection via controlled intracellular trafficking2008
- Author(s)
  M. Oba, K. Aoyagi, K. Miyata, Y. Matsumoto, K. Itaka, N. Nishiyama, Y. Yamasaki, H. Koyama, K. Kataoka
- Journal Title
  
  Mol. Pharmaceutics
  
  Volume: 5(6) Pages: 1080-1092
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20689024
[Journal Article] Polyplex micelles with cyclic RGD peptide ligands and disulfide cross-links directing to the enhanced transfection via controlled intracellular trafficking2008
- Author(s)
  Oba M., Koyama H., Kataoka K, et al.
- Journal Title
  
  Molecular Pharmaceutics 5 (6)
  
  Pages: 1080-92
- Data Source
  KAKENHI-PROJECT-19390510
[Journal Article] Polyplexes from poly(aspartamide) bearing 1, 2-diaminoethane side chains induce pH-selective, endosomal membrane destabilization with amplified transfection and negligible cytotoxicity2008
- Author(s)
  K. Miyata, M. Oba, M. Nakanishi, S. Fukushima, Y. Yamasaki, H. Koyama, N. Nishiyama, K. Kataoka
- Journal Title
  
  J. Am. Chem. Soc
  
  Volume: 130(8) Pages: 16287-16294
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20689024
[Journal Article] Polyplexes from poly(aspartamide)bearing 1,2-diaminoethane side chains induce pH-sensitive, endosomal membrane destabilization with amplified transfection and neglible cytotoxicity2008
- Author(s)
  K. Miyata, M. Oba, et.al.
- Journal Title
  
  Journal of the American Chemical Society 130(48)
  
  Pages: 16287-16294
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20689024
[Journal Article] Cyclic RGD petide-conjugated polyplex micelles as a target able gene dilivery system directed to cells possessing avb3 and avb5 integrins2007
- Author(s)
  Oba M, Koyama H, et al
- Journal Title
  
  Bioconjugate Chemistry 18
  
  Pages: 1415-1423
- Data Source
  KAKENHI-PROJECT-19390510
[Journal Article] Study of quantitative aminolysis reaction poly(□-benzyl L-aspartate)(PBLA)as a platform polymer for functionality materials2007
- Author(s)
  Oba M, Koyama H, et. al.
- Journal Title
  
  Reactive & Functional Polymers 18
  
  Pages: 1361-1372
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390345
[Journal Article] Study of quantitative aminolysis reaction poly(ロ-benzyl L-aspartate) (PBLA) as a platform polymer for functionality materials2007
- Author(s)
  Oba M, Koyama H, et. al.
- Journal Title
  
  Reactive & Functional Polymers 18
  
  Pages: 1361-1372
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390510
[Journal Article] Cyclic RGD peptide-conjugated polyplex micelles as a targetable gene delivery system directed to cells possessing avb3 and avb5 integrins2007
- Author(s)
  Oba M, Koyama H, et al
- Journal Title
  
  Bioconjugate Chemistry 18
  
  Pages: 1415-1423
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390345
[Journal Article] Biocompatible micellar nanovectors achieve efficient gene transfer to vascular lesions without cytotoxicity and thrombus formation2007
- Author(s)
  Akagi D, Oba M, Koyama H, Miyata T, et al.
- Journal Title
  
  Gene Therapy (In press)
- Data Source
  KAKENHI-PROJECT-17390345
[Patent] 新規膜透過性ペプチド2015
- Inventor(s)
  大庭　誠、田中正一
- Industrial Property Rights Holder
  大庭　誠、田中正一
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2015-072030
- Filing Date
  2015-03-31
- Data Source
  KAKENHI-PROJECT-25713008
[Patent] 電荷変換型三元系ポリプレックス2009
- Inventor(s)
  片岡一則, 宮田完二郎, Lee Yan, 大庭誠, 西山伸宏, 比木茂寛, 三條舞, Kim Hyn Jin
- Industrial Property Rights Holder
  片岡一則, 宮田完二郎, Lee Yan, 大庭誠, 西山伸宏, 比木茂寛, 三條舞, Kim Hyn Jin
- Filing Date
  2009-04-30
- Data Source
  KAKENHI-PROJECT-20689024
[Patent] エンドソーム脱出機能を有する電荷変換型三元系ポリプレックス2008
- Inventor(s)
  片岡一則、Yan Lee、宮田完二郎、大庭誠
- Industrial Property Rights Holder
  東京大学
- Filing Date
  2008-04-30
- Overseas
- Data Source
  KAKENHI-PROJECT-20650065
[Patent] エンドソーム脱出機能を有する電荷変換型二元系ポリプレックス2008
- Inventor(s)
  片岡一則、YanLee、宮田完二郎、大庭誠
- Industrial Property Rights Holder
  東京大学
- Filing Date
  2008-04-30
- Overseas
- Data Source
  KAKENHI-PROJECT-20689024
[Presentation] Aib含有ペプチドフォルダマーを用いたプラスミドDNAデリバリー2019
- Author(s)
  大庭誠, 伊藤有理香, 加藤巧馬, 田中正一
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-17H07269
[Presentation] 膜透過性ペプチドへの応用のための環状ジ置換アミノ酸の合成2018
- Author(s)
  加藤巧馬、大庭　誠、田中正一、土井光暢
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-17H07269
[Presentation] Design and Synthesis of Cyclic Disubstituted Amino Acids for Development of Cell Penetrating Peptide2018
- Author(s)
  Takuma Kato, Akiko Asano, Makoto Oba, Masakazu Tanaka, Mitsunobu Doi
- Organizer
  10th International Peptide Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H07269
[Presentation] Synthesis of a Chiral Three-Membered Ring α,α-Disubstituted α-Amino Acid Having Two Methyl Groups and Conformational Analysis of its Peptides2018
- Author(s)
  Hikaru Ikeda, Atsushi Ueda, Makoto Oba, Takuma Kato, Mitsunobu Doi, Masakazu Tanaka
- Organizer
  10th International Peptide Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H07269
[Presentation] 非天然型アミノ酸を含有するペプチドフォルダマーの二次構造と膜透過機能2018
- Author(s)
  大庭　誠, 永野優, 加藤巧馬, 田中正一
- Organizer
  日本ケミカルバイオロジー学会第13回年会
- Data Source
  KAKENHI-PROJECT-17H07269
[Presentation] Development and evaluation of cell-penetrating pe ptides having cyclic disubstituted amino acids2017
- Author(s)
  加藤巧馬、大庭　誠、田中正一
- Organizer
  第54回ペプチド討論会
- Data Source
  KAKENHI-PROJECT-17H07269
[Presentation] α,α-ジ置換アミノ酸を含有するペプチドの二次構造と膜透過機能の評価2017
- Author(s)
  大庭　誠、山澤翔太、國武正幸、江藤　諒、永野　優、伊藤有理香、加藤巧馬、田中正一
- Organizer
  日本ケミカルバイオロジー学会第12回年会
- Data Source
  KAKENHI-PROJECT-17H07269
[Presentation] EVALUATION OF CATIONIC AMPHIPHILIC PEPTIDES AS POTENTIAL PROBES FOR CANCER IMAGING2016
- Author(s)
  Yu Fukushima, Takeshi Fuchigami, Hiromi Inoue, Natsumi Ishikawa, Sakura Yoshida, Makoto Oba, and Morio Nakayama
- Organizer
  第53回ペプチド討論会
- Place of Presentation
  京都テルサ（京都府・京都市）
- Year and Date
  2016-10-26
- Data Source
  KAKENHI-PROJECT-15K09895
[Presentation] Cell-penetrating peptide foldamers containing a,a-disubstituted a-amino acids directed to plasmid DNA delivery2016
- Author(s)
  Makoto Oba, Takuma Kato, Masakazu Tanaka
- Organizer
  Symposium on Foldamers 2016
- Place of Presentation
  Bordeaux-Pessac, France
- Year and Date
  2016-09-26
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25713008
[Presentation] Gene delivery using a cell-penetrating peptide with a guanidinylethyl amine structure2016
- Author(s)
  Makoto Oba, Kaori Furukawa, Takuma Kato, Masakazu Tanaka
- Organizer
  The 8th Takeda Science Foundation Symposium on PharmaSciences, Biomolecule-Based Medicinal Science: Featuring Mid-Size Drugs
- Place of Presentation
  武田薬品研修所（大阪府・吹田市）
- Year and Date
  2016-01-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25713008
[Presentation] Synthesis of peptides having an a,a-disubstituted amino acid with a variable side chain structure responsive to reduction2015
- Author(s)
  Hikaru Nonaka, Makoto Oba, Mitsunobu Doi, Masakazu Tanaka
- Organizer
  第52回ペプチド討論会
- Place of Presentation
  平塚中央公民館（神奈川県・平塚市）
- Year and Date
  2015-11-16
- Data Source
  KAKENHI-PROJECT-25560226
[Presentation] 環境変化に応答して側鎖構造を変化させるジ置換アミノ酸とその含有ペプチドの合成および構造解析2015
- Author(s)
  農中ひかる、土井光暢、大庭　誠、田中正一
- Organizer
  日本ケミカルバイオロジー学会第10回年会
- Place of Presentation
  東北大学（宮城県・仙台市）
- Year and Date
  2015-06-10
- Data Source
  KAKENHI-PROJECT-25560226
[Presentation] 還元反応に応答して側鎖構造を変化させるジ置換アミノ酸の合成とその含有ペプチドの二次構造解析2015
- Author(s)
  農中ひかる、土井光暢、大庭　誠、田中正一
- Organizer
  第32回日本薬学会九州支部大会
- Place of Presentation
  九州保健福祉大学（宮崎県・延岡市）
- Year and Date
  2015-11-28
- Data Source
  KAKENHI-PROJECT-25560226
[Presentation] アルギニン含有ペプチドの細胞膜透過性とpDNAデリバリーに関する研究2015
- Author(s)
  大庭　誠、古川かほり、加藤巧馬、山下博子、出水庸介、栗原正明、田中正一
- Organizer
  第31回日本DDS学会学術集会
- Place of Presentation
  京王プラザホテル（東京都・新宿区）
- Year and Date
  2015-07-02
- Data Source
  KAKENHI-PROJECT-25713008
[Presentation] ドラッグデリバリーペプチドの開発2015
- Author(s)
  大庭　誠
- Organizer
  BioJapan 2015
- Place of Presentation
  パシフィコ横浜（神奈川県・横浜市）
- Year and Date
  2015-10-14
- Data Source
  KAKENHI-PROJECT-25713008
[Presentation] 酸化・還元反応に応答して側鎖構造を変化させるジ置換アミノ酸の合成2015
- Author(s)
  農中ひかる、土井光暢、大庭　誠、田中正一
- Organizer
  第39回有機電子移動化学討論会
- Place of Presentation
  長崎大学（長崎県・長崎市）
- Year and Date
  2015-06-25
- Data Source
  KAKENHI-PROJECT-25560226
[Presentation] Cell-penetrating ability and plasmid DNA delivery using fluorescein-labeled arginine-rich peptides2015
- Author(s)
  Makoto Oba, Kaori Furukawa, Takuma Kato, Yosuke Demizu, Hiroko Yamashita, Masaaki Kurihara, Masakazu Tanaka
- Organizer
  11th Australian Peptide Conference
- Place of Presentation
  Kingscliff (Australia)
- Year and Date
  2015-10-25
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25713008
[Presentation] グアニジニルエチルアミン構造を側鎖に有する非天然型アミノ酸を利用した膜透過性ペプチドの開発2015
- Author(s)
  大庭　誠、古川かほり、加藤巧馬、田中正一
- Organizer
  日本ケミカルバイオロジー学会第10回年会
- Place of Presentation
  東北大学（宮城県・仙台市）
- Year and Date
  2015-06-10
- Data Source
  KAKENHI-PROJECT-25713008
[Presentation] Environmentally-responsive cyclic a,a-disubstituted a-amino acids for controlling peptide secondary structures2015
- Author(s)
  Makoto Oba, Hikaru Nounaka, Kaori Furukawa, Kotomi Toyama, Masakazu Tanaka
- Organizer
  Pacifichem 2015
- Place of Presentation
  Honolulu, Hawaii, USA
- Year and Date
  2015-12-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25560226
[Presentation] 細胞膜透過性ヘリカルペプチドの創製2014
- Author(s)
  山下博子、出水庸介、佐藤由紀子、大庭　誠、田中正一、栗原正明
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本県熊本市熊本大学
- Data Source
  KAKENHI-PROJECT-25713008
[Presentation] アキラルな五員環状アミノ酸を含有する細胞膜透過性ヘリカルペプチドの評価2014
- Author(s)
  加藤巧馬、大庭　誠、田中正一
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本県熊本市熊本大学
- Data Source
  KAKENHI-PROJECT-25713008
[Presentation] 細胞膜透過性ヘリカルペプチドの開発2013
- Author(s)
  大庭　誠、加藤巧馬、田中正一
- Organizer
  第29回日本DDS学会学術集会
- Place of Presentation
  京都府京都市京都テルサ
- Data Source
  KAKENHI-PROJECT-25713008
[Presentation] 五員環状アミノ酸を含有するヘリカルペプチドの細胞膜透過性の評価2013
- Author(s)
  加藤巧馬、大庭　誠、田中正一
- Organizer
  第30回日本薬学会九州支部大会
- Place of Presentation
  長崎県佐世保市長崎国際大学
- Data Source
  KAKENHI-PROJECT-25713008
[Presentation] PEG-detachable polyaspartamide derivative block copolymer bearing stearoyl moieties for in vivo siRNA delivery2011
- Author(s)
  H. J. Kim, M. Oba, F. Pittella, T. Nomoto, H. Cabral, Y. Matsumoto, K. Miyata, N. Nishiyama, K. Kataoka
- Organizer
  第60回高分子討論会
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-20689024
[Presentation] Enhanced transfection by binary polyion complex from block- and homo-polycations towards systemic gene therapy2011
- Author(s)
  Qixian Chen, Makoto Oba, Takehiko Ishii, Kensuke Osada, Kazunori Kataoka
- Organizer
  第60回高分子年次大会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-20689024
[Presentation] DDS素材としての可能性を秘めた非天然型アミノ酸含有ペプチドに関する基礎的研究2011
- Author(s)
  大庭誠, 平田陽子, 加藤和也, 田中正一
- Organizer
  第27回日本DDS学会学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-20689024
[Presentation] Enhanced transfection by binary polyion complex from block-and homo-polycations towards systemic gene therapy2011
- Author(s)
  Q. Chen, M. Oba, T. Ishii, K. Osada, K. Kataoka
- Organizer
  第60回高分子年次大会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-20689024
[Presentation] Antiangiogenic gene therapy of subcutaneous pancreatic tumor by systemic injection of polyplex micelles loading sFlt-1 plasmid DNA2010
- Author(s)
  Makoto Oba, Yelena Vachutinsky, Kanjiro Miyata, Nobuhiro Nishiyama, Hiroyuki Koyama, Kazunori Kataoka
- Organizer
  PACIFICHEM 2010
- Place of Presentation
  Honolulu
- Data Source
  KAKENHI-PROJECT-20689024
[Presentation] 化学量論的な電荷比を超えて会合する高分子ミセル型遺伝子ベクターの設計とその機能評価2010
- Author(s)
  大庭誠, 宮田完二郎, 長田健介, 福島重人, 西山伸宏, 小山博之, 片岡一則
- Organizer
  遺伝子・デリバリー研究会第10回シンポジウム
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-20689024
[Presentation] 化学両論的な電化比を超えて会合する高分子ミセル型遺伝子ベクターの設計とその機能評価2010
- Author(s)
  大庭誠, 宮田完二郎, 長田健介, 福島重人, 西山伸宏, 小山博之, 片岡一則
- Organizer
  遺伝子・デリバリー研究会第10回シンポジウム
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-20689024
[Presentation] Polyplex micelles with cyclic RGD peptide ligands and disulfide crosslinks directed to the enhanced transfection by controlling intracellular trafficking2010
- Author(s)
  M.Oba, et al
- Organizer
  Biomaterials Asia 2009
- Place of Presentation
  Hong Kong, 中国
- Data Source
  KAKENHI-PROJECT-20650065
[Presentation] Antiangiogenic gene therapy of subcutaneous pancreatic tumor by systemic injection of polyplex micelles loading sFlt-1 plasmid DNA2010
- Author(s)
  M.Oba, Y.Vachutinsky, K.Miyata, N.Nishiyama, H.Koyama, K.Kataoka
- Organizer
  PACIFICHEM 2010
- Place of Presentation
  Honolulu, USA
- Data Source
  KAKENHI-PROJECT-20689024
[Presentation] Antiangiogenic gene therapy of subcutaneous pancreatic tumor by systemic injection of polyplex micelles loading sFlt-1 plasmid DNA2010
- Author(s)
  M. Oba, Y. Vachutinsky, K. Miyata, N. Nishiyama, H. Koyama, K. Kataoka
- Organizer
  PACIFICHEM 2010
- Place of Presentation
  Honolulu, Hawaii, USA
- Data Source
  KAKENHI-PROJECT-20689024
[Presentation] 膵臓がんの遺伝子治療を目指した高分子ミセル型遺伝子ベクターの開発2009
- Author(s)
  大庭誠, Y. Vachutinsky, 宮田完二郎, 狩野光伸, 宮園浩平, 西山伸宏, 位高啓史, 小山博之, 片岡一則
- Organizer
  遺伝子・デリバリー研究会第9回シンポジウム
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-20689024
[Presentation] 高分子ミセル型遺伝子ベクターを用いた膵臓がんの遺伝子治療法の開発2009
- Author(s)
  大庭誠, Vachutinsky Yelena, 宮田完二郎, 狩野光伸, 宮園浩平, 西山伸宏, 小山博之, 片岡一則
- Organizer
  第31回日本バイオマテリアル学会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-20689024
[Presentation] 高分子ミセル型遺伝子ベクターを用いた膵臓がんの遺伝子治療法の開発2009
- Author(s)
  大庭誠, Y. Vachutinsky, 宮田完二郎, 狩野光伸, 宮園浩平, 西山伸宏, 小山博之, 片岡一則
- Organizer
  第31回日本バイオマテリアル学会大会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-20689024
[Presentation] Anti-angiogenic gene therapy of pancreatic adenocarcinoma using ppolyplex micelles with plasmid DNA encoding soluble form of Flt-12009
- Author(s)
  Makoto Oba, Yelena Vachutinsky, Kanjiro Miyata, Sorato Ikeda, Nobuhiro Nishiyama, Hiroyuki Koyama, Kazunori Kataoka
- Organizer
  The 10th US-Japan Symposium on Drug Delivery System
- Place of Presentation
  Maui
- Data Source
  KAKENHI-PROJECT-20689024
[Presentation] Anti-angiogenic gene therapy of pancreatic adenocarcinoma using polyplex micelles with plasmid DNA encoding soluble form of Flt-12009
- Author(s)
  M. Oba, Y. Vachutinsky, K. Miyata, S. Ikeda, N. Nishiyama, H. Koyama, K. Kataoka
- Organizer
  The 10th US-Japan Symposium on Drug Delivery System
- Place of Presentation
  Maui
- Data Source
  KAKENHI-PROJECT-20689024
[Presentation] Anti-angiogenic gene therapy of pancreatic adenocarcinoma using polyplex micelles with plasmid DNA encoding soluble form of Flt-12009
- Author(s)
  大庭誠, et al
- Organizer
  The 10^<th> US-Japan Symposium on Drug Delivery System
- Place of Presentation
  Maui, USA
- Data Source
  KAKENHI-PROJECT-20689024
[Presentation] Anti-angiogenic gene therapy for pancreatic cancer by systemic administration of polyplex micelles2008
- Author(s)
  M. Oba
- Organizer
  CMSI-GCOE Students Workshop : Frontiers in Nanomedicine
- Place of Presentation
  Tokyo
- Year and Date
  2008-11-19
- Data Source
  KAKENHI-PROJECT-20689024
[Presentation] Functional assessment of polyplex micelles with cyclic RGD peptide ligands and disulfide crosslinked core2008
- Author(s)
  M. Oba, K. Aoyagi, K. Miyata, N. Nishiyama, H. Koyama, K. Kataoka
- Organizer
  35^<th> Annual Meeting & Exposition of the Controlled Release Society
- Place of Presentation
  New York
- Data Source
  KAKENHI-PROJECT-20689024
[Presentation] Functional assessment of polyplex micelles with cyclic RGD peptide ligands and disulfide crosslinked core2008
- Author(s)
  Makoto Oba, Kazuhiro Aoyagai, Kanjiro Miyata, Nobuhiro Nishiyama, Hiroyuki Koyama, Kazunori Kataoka
- Organizer
  35th Annual Meeting & Exposition of the Controlled Release Society
- Place of Presentation
  New York
- Data Source
  KAKENHI-PROJECT-20689024
[Presentation] 疎水性相互作用により安定化されたポリプレックスミセル型遺伝子ベクター2008
- Author(s)
  大庭誠, 宮田完二郎, 福島重人, 長田健介, 位高啓史, 西山伸宏, 小山博之, 片岡一則
- Organizer
  遺伝子・デリバリー研究会第8回シンポジウム
- Place of Presentation
  大阪
- Year and Date
  2008-05-09
- Data Source
  KAKENHI-PROJECT-20689024
[Presentation] 疎水性相互作用を利用した高分子ミセル型遺伝子ベクターの開発2008
- Author(s)
  大庭誠, 宮田完二郎, 福島重人, 長田健介, 位高啓史, 西山伸宏, 小山博之, 片岡一則
- Organizer
  第24回日本DDS学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-20689024
[Presentation] Polyplex micelles from plasmid DNA and PEG-based block copolymer with environmental-responsive crosslinks and targetable ligands2008
- Author(s)
  Makoto Oba, , et al
- Organizer
  第14回日本遺伝子治療学会総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-20650065
[Presentation] 疎水性相互作用を利用した高分子ミセル型遺伝子キャリアの開発2008
- Author(s)
  大庭誠, 宮田完二郎, 福島重人, 位高啓史, 西山伸宏, 小山博之, 片岡一則
- Organizer
  第37回医用高分子シンポジウム
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-20689024
[Presentation] Functional assessment of polyplex micelles with cyclic RGD peptide ligands and disulfide crosslinked core2008
- Author(s)
  M. Oba, et al
- Organizer
  35^<th> Annual Meeting & Exposition of the Controlled Release Society
- Place of Presentation
  New York, USA
- Data Source
  KAKENHI-PROJECT-20689024
[Presentation] Polyplex micelles from plasmid DNA and PEG-based block copolymer with environmental-responsive crosslinks and targetable ligands2008
- Author(s)
  M. Oba, K. Aoyagi, K. Miyata, K. Itaka, N. Nishiyama, H. Koyama, K. Kataoka
- Organizer
  第14回日本遺伝子治療学会総会
- Place of Presentation
  Sapporo
- Data Source
  KAKENHI-PROJECT-20689024
[Presentation] ジ置換アミノ酸を含有する細胞膜透過性ヘリカルペプチドの開発
- Author(s)
  加藤巧馬、楠富伊織、大庭　誠、田中正一
- Organizer
  第50回化学関連支部合同九州大会
- Place of Presentation
  福岡県北九州市北九州国際会議場
- Data Source
  KAKENHI-PROJECT-25713008
[Presentation] 五員環状アミノ酸を利用した細胞膜透過性ヘリカルペプチドの開発
- Author(s)
  加藤巧馬、大庭　誠、田中正一
- Organizer
  第30回日本DDS学会学術集会
- Place of Presentation
  東京　慶応大学
- Year and Date
  2014-07-30 – 2014-07-31
- Data Source
  KAKENHI-PROJECT-25713008
[Presentation] 環境変化に応答して側鎖構造を変化させるジ置換アミノ酸とその含有ペプチドの合成
- Author(s)
  農中ひかる、土井光暢、大庭　誠、田中正一
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸　神戸学院大学等
- Year and Date
  2015-03-25 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-25560226
[Presentation] 五員環状ジ置換アミノ酸を利用した新規膜透過性ペプチドの開発
- Author(s)
  加藤巧馬、大庭　誠、西田孝洋、田中正一
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸　神戸学院大学、他
- Year and Date
  2015-03-25 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-25713008
[Presentation] 五員環状アミノ酸を含有する膜透過性ヘリカルペプチドの開発
- Author(s)
  大庭　誠、加藤巧馬、田中正一
- Organizer
  第32回メディシナルケミストリーシンポジウム
- Place of Presentation
  神戸　神戸国際会議場
- Year and Date
  2014-11-26 – 2014-11-28
- Data Source
  KAKENHI-PROJECT-25713008
[Presentation] Evaluation of cell-penetrating ability of helical peptides having achiral five-membered α,α-disubstituted amino acids
- Author(s)
  Takuma Kato, Makoto Oba, Masakazu Tanaka
- Organizer
  33rd European Peptide Symposium
- Place of Presentation
  ブルガリア　ソフィア
- Year and Date
  2014-08-31 – 2014-09-05
- Data Source
  KAKENHI-PROJECT-25713008

1. KOYAMA Hiroyuki (10241994)

# of Collaborated Projects: 2 results

# of Collaborated Products: 16 results
2. CHIKAZU Daichi (30343122)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. MORI Yoshiyuki (70251296)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. YONEHARA Hiroyuki (00251299)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. MIYATA Tetsuro (70190791)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. SHIGEMATSU Kunihuri (20215966)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. KIMURA Hideo (60327070)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. FUCHIGAMI Takeshi (30432206)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
9. Kato Takuma (20805296)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
10. Tanaka Masakazu (00227175)

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
11. Doi Mitsunobu (10183500)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
12. Uchida Satoshi (20710726)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
13. 片岡一則 (00130245)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 岡本宏之 (60348266)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 吉田さくら (40736419)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
16. 中山守雄 (60164373)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
17. Huc Ivan

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. KAWASAKI Masao

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 出水庸介

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
20. 末宗洋

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 上田篤志

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. 阿部洋

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. 西弘大

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

OBA Makoto 大庭 誠

大庭 誠 オオバ マコト

Research Projects

Research Products

Co-Researchers

In situ PEGylation of extracellular DNA using functional peptides for anti-inflammatory therapy

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of cell penetrating peptide utilizing the charactaristic of disubstituted amino acid

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of fusion peptides of beta-hairpin peptides and survivin binding molecules as cancer-specific internal radiotherapeutic agents

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of cell-penetrating peptides and their application to DDS carriers(Fostering Joint International Research)Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of artificial peptides reversibly changing their secondary structures in response to reductive conditionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of cell-penetrating peptides and their application as DDS carriersPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

血液脳関門突破を目指したドラッグデリバリーシステムの創製Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of gene therapy for vascular disease using multi-functional polymeric micellar gene vectorPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of novel living material by regulation of angiogenesis

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Gene delivery using polyion complex micelle for the treatment of aortic aneurysm

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] An Amphipathic Structure of a Dipropylglycine-Containing Helical Peptide with Sufficient Length Enables Safe and Effective Intracellular siRNA Delivery2023

Author(s)

Journal Title

DOI

ISSN

Year and Date

Language

Data Source

[Journal Article] Cell-Penetrating Peptides: Emerging Tools for mRNA Delivery2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A helix foldamer oligopeptide improves intracellular stability and prolongs protein expression of the delivered mRNA2021

Author(s)

OBA Makoto 大庭誠

大庭誠オオバマコト