TAWARAYAMA HIROSHI 俵山寛司

… Alternative Names

TAWARAYAMA Hiroshi 俵山寛司

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Researcher Number	20402414
Other IDs	https://orcid.org/0000-0001-8696-6700
Affiliation (Current)	2025: 東北大学, 医学系研究科, 助教
Affiliation (based on the past Project Information) *help	2016 – 2024: 東北大学, 医学系研究科, 助教 2014 – 2015: 東北大学, 生命科学研究科, 教育研究支援者 2013: 熊本大学, 生命科学研究部, 学術研究員
Review Section/Research Field	Principal Investigator Basic Section 56060:Ophthalmology-related / Nerve anatomy/Neuropathology Except Principal Investigator Basic Section 56060:Ophthalmology-related
Keywords	Principal Investigator 抗炎症 / draxin / 抗酸化 / グルタチオン過硫化物 / 加齢性眼疾患 / グルタチオン三硫化物 / 超硫黄 / 活性イオウ分子種 / NMDA傷害モデル / 興奮性網膜神経細胞死 … More / 神経保護 / 網膜神経節細胞 / NMDA / K560 / HDAC阻害剤 / 緑内障 / 酸化ストレス / 網膜神経細胞死 / HDAC1/2阻害剤 / neuronal cell death / hippocampal neurogenesis / 神経分化 / アポトーシス / 海馬神経新生 / DCC / Draxin / 軸索ガイダンス分子 / 神経栄養因子 / 軸索ガイダンス因子 / ドラキシン / 神経新生 / 海馬 … More Except Principal Investigator 酸化ストレス / 線維化 / STING / 加齢黄斑変性 / 難治性眼疾患 / 抗炎症 / 抗酸化 / 活性イオウ分子種 / ゲノムワイド関連解析 / 網膜神経節細胞 / 緑内障 Less

新規眼内炎症緩和剤として期待される活性イオウ分子種によるIL1B発現制御機序の解明Principal Investigator
- Principal Investigator
  
  俵山寛司
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56060:Ophthalmology-related
- Research Institution
  Tohoku University
GWASによる緑内障感受性遺伝子CDKN2B-AS1のメカニズム解明
- Principal Investigator
  
  面高宗子
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56060:Ophthalmology-related
- Research Institution
  Tohoku University
グルタチオン三硫化物GSSSGの抗酸化・抗炎症作用に基づく難治性眼疾患の病態制御
- Principal Investigator
  
  國方彦志
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56060:Ophthalmology-related
- Research Institution
  Tohoku University
STING経路に着目した滲出型加齢黄斑変性の網膜下線維化の病態解明
- Principal Investigator
  
  安田正幸
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56060:Ophthalmology-related
- Research Institution
  Tohoku University
Elucidation of the anti-inflammatory mechanism by active sulfur species aimed at the treatment and alleviation of inflammatory eye diseasesPrincipal Investigator
- Principal Investigator
  
  Tawarayama Hiroshi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56060:Ophthalmology-related
- Research Institution
  Tohoku University
Development of a HDAC1/2 inhibitor K560-mediated treatment for glaucomaPrincipal Investigator
- Principal Investigator
  
  Tawarayama Hiroshi
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56060:Ophthalmology-related
- Research Institution
  Tohoku University
The roles of the chamorepellent draxin in hippocampal neurogenesisPrincipal Investigator
- Principal Investigator
  
  Tawarayama Hiroshi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Tohoku University
Roles of draxin in hippocampal development as a neurotrophic factorPrincipal Investigator
- Principal Investigator
  
  TAWARAYAMA Hiroshi
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Tohoku University
  Kumamoto University

All 2023 2022 2021 2020 2019 2018 2017 2016 2013 Other

All Journal Article Presentation Patent

[Journal Article] Glutathione trisulfide prevents lipopolysaccharide-induced retinal inflammation via inhibition of proinflammatory cytokine production in glial cells2023
- Author(s)
  Tawarayama Hiroshi、Umeki Kota、Inoue-Yanagimachi Maki、Takahashi Naoki、Hasegawa Hirokazu、Himori Noriko、Tsuda Satoru、Kunikata Hiroshi、Akaike Takaaki、Nakazawa Toru
- Journal Title
  
  Scientific Reports
  
  Volume: 13 Issue: 1 Pages: 11513-11513
- DOI
  10.1038/s41598-023-38696-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K19397, KAKENHI-PROJECT-23K20040, KAKENHI-PROJECT-23K09037, KAKENHI-PROJECT-21K09714, KAKENHI-PROJECT-21K09736, KAKENHI-PLANNED-21H05263, KAKENHI-PROJECT-18H05277
[Journal Article] Changes in glial cells and neurotrophic factors due to rotenone-induced oxidative stress in Nrf2 knockout mice.2022
- Author(s)
  Inoue-Yanagimachi M, Himori N, Uchida K, Tawarayama H, Sato K, Yamamoto M, Namekata K, Harada T, Nakazawa T.
- Journal Title
  
  Experimental Eye Research.
  
  Volume: 226 Pages: 109314-109314
- DOI
  10.1016/j.exer.2022.109314
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K09736, KAKENHI-PROJECT-23K06818, KAKENHI-PROJECT-21K09714
[Journal Article] Isozyme-specific histone deacetylase 1/2 inhibitor K560 attenuates oxidative stress-induced retinal cell death.2022
- Author(s)
  Tawarayama H, Hirata Y, Keiko U, Himori N, Uesato S, Nakazawa T.
- Journal Title
  
  Neuroscience Letter
  
  Volume: 793 Pages: 106978-106978
- DOI
  10.1016/j.neulet.2022.136978
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K09736, KAKENHI-PROJECT-21K09714
[Journal Article] Development of an anti-oxidative intraocular irrigating solution based on reactive persulfides2022
- Author(s)
  Kunikata Hiroshi、Tawarayama Hiroshi、Tsuda Satoru、Akaike Takaaki、Nakazawa Toru
- Journal Title
  
  Scientific Reports
  
  Volume: 12 Issue: 1 Pages: 19243-12316
- DOI
  10.1038/s41598-022-21677-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K19397, KAKENHI-PROJECT-21K09714, KAKENHI-PLANNED-21H05263, KAKENHI-PROJECT-18H05277
[Journal Article] Glial cells modulate retinal cell survival in rotenone-induced neural degeneration.2021
- Author(s)
  Tawarayama H, Inoue-Yanagimachi M, Himori N, Nakazawa T.
- Journal Title
  
  Sci Rep.
  
  Volume: 11 Issue: 1 Pages: 11159-11159
- DOI
  10.1038/s41598-021-90604-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K09736, KAKENHI-PROJECT-21K09714
[Journal Article] Glutathione Trisulfide Prevents Lipopolysaccharide-induced Inflammatory Gene Expression in Retinal Pigment Epithelial Cells2020
- Author(s)
  Tawarayama Hiroshi、Suzuki Noriyuki、Inoue-Yanagimachi Maki、Himori Noriko、Tsuda Satoru、Sato Kota、Ida Tomoaki、Akaike Takaaki、Kunikata Hiroshi、Nakazawa Toru
- Journal Title
  
  Ocular Immunology and Inflammation
  
  Volume: in press Issue: 4 Pages: 1-12
- DOI
  10.1080/09273948.2020.1833224
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07306, KAKENHI-PROJECT-18K09434, KAKENHI-PROJECT-17H06170, KAKENHI-PROJECT-18H05277
[Journal Article] Draxin-mediated Regulation of Granule Cell Progenitor Differentiation in the Postnatal Hippocampal Dentate Gyrus.2020
- Author(s)
  Tawarayama H, Yamada H, Amin R, Morita-Fujimura Y, Cooper HM, Shinmyo Y, Tanaka H, Ikawa S.
- Journal Title
  
  Neuroscience
  
  Volume: 431 Pages: 184-192
- DOI
  10.1016/j.neuroscience.2020.02.005
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K19376, KAKENHI-PROJECT-17K07152, KAKENHI-PROJECT-18K09434
[Journal Article] Cyclin-Dependent Kinase Inhibitor 2b Mediates Excitotoxicity-Induced Death of Retinal Ganglion Cells2019
- Author(s)
  Tawarayama Hiroshi、Feng Qiwei、Murayama Namie、Suzuki Noriyuki、Nakazawa Toru
- Journal Title
  
  Investigative Opthalmology & Visual Science
  
  Volume: 60 Issue: 13 Pages: 4479-4479
- DOI
  10.1167/iovs.19-27396
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09434
[Journal Article] Draxin regulates hippocampal neurogenesis in the postnatal dentate gyrus by inhibiting DCC-induced apoptosis.2018
- Author(s)
  Tawarayama H, Yamada H, Amin R, Morita-Fujimura Y, Cooper HM, Shinmyo Y, Kawata M, Ikawa S, Tanaka H.
- Journal Title
  
  Sci Rep.
  
  Volume: 8(1) Issue: 1 Pages: 840-840
- DOI
  10.1038/s41598-018-19346-6
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06733, KAKENHI-PROJECT-17K07152
[Journal Article] Ecel1 Knockdown With an AAV2-Mediated CRISPR/Cas9 System Promotes Optic Nerve Damage-Induced RGC Death in the Mouse Retina2018
- Author(s)
  Sato Kota、Shiga Yukihiro、Nakagawa Yurika、Fujita Kosuke、Nishiguchi Koji M.、Tawarayama Hiroshi、Murayama Namie、Maekawa Shigeto、Yabana Takeshi、Omodaka Kazuko、Katayama Shota、Feng Qiwei、Tsuda Satoru、Nakazawa Toru
- Journal Title
  
  Investigative Opthalmology & Visual Science
  
  Volume: 59 Issue: 10 Pages: 3943-3943
- DOI
  10.1167/iovs.18-23784
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09434, KAKENHI-PROJECT-17K16956
[Journal Article] Novel function of the chemorepellent draxin as a regulator for hippocampal neurogenesis2018
- Author(s)
  Tawarayama Hiroshi
- Journal Title
  
  Neural Regeneration Research
  
  Volume: 13 Issue: 5 Pages: 799-799
- DOI
  10.4103/1673-5374.232465
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09434
[Journal Article] The chemorepellent draxin is involved in hippocampal mossy fiber projection.2018
- Author(s)
  Tawarayama H, Yamada H, Shinmyo Y, Tanaka H, Ikawa S.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 500 Issue: 2 Pages: 217-223
- DOI
  10.1016/j.bbrc.2018.04.043
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07152, KAKENHI-PROJECT-18K09434, KAKENHI-PROJECT-18K19376, KAKENHI-PROJECT-16H04654
[Journal Article] The neuroprotective effect of hesperidin in NMDA-induced retinal injury acts by suppressing oxidative stress and excessive calpain activation2017
- Author(s)
  Maekawa Shigeto、Sato Kota、Fujita Kosuke、Daigaku Reiko、Tawarayama Hiroshi、Murayama Namie、Moritoh Satoru、Yabana Takeshi、Shiga Yukihiro、Omodaka Kazuko、Maruyama Kazuichi、Nishiguchi Koji M.、Nakazawa Toru
- Journal Title
  
  Sci Rep
  
  Volume: 7 Issue: 1 Pages: 1-13
- DOI
  10.1038/s41598-017-06969-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K11475, KAKENHI-PROJECT-15K06733
[Journal Article] Metabolomic profiling of reactive persulfides and polysulfides in the aqueous and vitreous humors.2017
- Author(s)
  Kunikata H, Ida T, Sato K, Aizawa N, Sawa T, Tawarayama H, Murayama N, Fujii S, Akaike T, Nakazawa T.
- Journal Title
  
  Sci Rep
  
  Volume: 7 Issue: 1 Pages: 41984-41984
- DOI
  10.1038/srep41984
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-26111008, KAKENHI-PROJECT-25220103, KAKENHI-PROJECT-15H03115, KAKENHI-PROJECT-15K06733, KAKENHI-PROJECT-15K08456, KAKENHI-PROJECT-16K15208, KAKENHI-PROJECT-15K20876
[Journal Article] ΔNp63α induces quiescence and downregulates the BRCA1 pathway in estrogen receptor-positive luminal breast cancer cell line MCF7 but not in other breast cancer cell lines.2016
- Author(s)
  Amin R, Morita-Fujimura Y, Tawarayama H, Semba K, Chiba N, Fukumoto M, Ikawa S
- Journal Title
  
  Molecular Oncology
  
  Volume: 10 Issue: 4 Pages: 575-593
- DOI
  10.1016/j.molonc.2015.11.009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K06733, KAKENHI-PROJECT-16H04690
[Patent] 眼内抗炎症剤2021
- Inventor(s)
  中澤徹、赤池孝章、國方彦志、俵山寛司、津田聡
- Industrial Property Rights Holder
  中澤徹、赤池孝章、國方彦志、俵山寛司、津田聡
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2021-187729
- Filing Date
  2021
- Data Source
  KAKENHI-PROJECT-21K09714
[Presentation] 活性イオウ分子種の抗酸化・抗炎症作用に基づく新規眼内灌流液の開発2021
- Author(s)
  俵山寛司, 鈴木哲章, 津田聡, 國方彦志, 中澤徹
- Organizer
  第3回Translational Research Conference for Neuroprotection
- Data Source
  KAKENHI-PROJECT-21K09714
[Presentation] Draxin regulates hippocampal neurogenesis in the postnatal dentate gyrus by inhibiting DCC-induced apoptosis and Wnt-driven differentiation2016
- Author(s)
  俵山寛司、山田博久、藤村維子、Ruhul Amin、Helen M Cooper、新明洋平、河田雅圭、井川俊太郎、田中英明
- Organizer
  第39回日本神経科学大会
- Place of Presentation
  パシフィコ横浜（横浜）
- Year and Date
  2016-07-20
- Data Source
  KAKENHI-PROJECT-15K06733
[Presentation] Draxin, a repulsive axon guidance molecule, functions as a neural survival-promoting factor in the developing hippocampus2013
- Author(s)
  Hiroshi Tawarayama, Hirohisa Yamada, Yohei Shinmyo, Hideaki Tanaka
- Organizer
  Neurogenesis in Matsushima
- Place of Presentation
  ホテル松島大観荘（宮城）
- Data Source
  KAKENHI-PROJECT-25870538
[Presentation] 軸索ガイダンス因子ドラキシンはWntシグナリングを調節することにより海馬神経新生を制御する
- Author(s)
  俵山寛司, 山田博久, 井川俊太郎, 新明洋平, 田中英明
- Organizer
  第37回日本分子生物学会
- Place of Presentation
  パシフィコ横浜（横浜）
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-25870538

1. 中澤徹 (30361075)

# of Collaborated Projects: 5 results

# of Collaborated Products: 6 results
2. 國方彦志 (40361092)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
3. 面高宗子 (80569583)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 安田正幸 (00569585)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 佐藤孝太 (50732327)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 井田智章

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
7. 檜森紀子

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
8. 丸山和一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 赤池孝章

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
10. 澤智裕

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 新明洋平

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 井川俊太郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

TAWARAYAMA HIROSHI 俵山 寛司

TAWARAYAMA Hiroshi 俵山 寛司

Research Projects

Research Products

Co-Researchers

新規眼内炎症緩和剤として期待される活性イオウ分子種によるIL1B発現制御機序の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

GWASによる緑内障感受性遺伝子CDKN2B-AS1のメカニズム解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

グルタチオン三硫化物GSSSGの抗酸化・抗炎症作用に基づく難治性眼疾患の病態制御

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

STING経路に着目した滲出型加齢黄斑変性の網膜下線維化の病態解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the anti-inflammatory mechanism by active sulfur species aimed at the treatment and alleviation of inflammatory eye diseasesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of a HDAC1/2 inhibitor K560-mediated treatment for glaucomaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The roles of the chamorepellent draxin in hippocampal neurogenesisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Roles of draxin in hippocampal development as a neurotrophic factorPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Glutathione trisulfide prevents lipopolysaccharide-induced retinal inflammation via inhibition of proinflammatory cytokine production in glial cells2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Changes in glial cells and neurotrophic factors due to rotenone-induced oxidative stress in Nrf2 knockout mice.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Isozyme-specific histone deacetylase 1/2 inhibitor K560 attenuates oxidative stress-induced retinal cell death.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Development of an anti-oxidative intraocular irrigating solution based on reactive persulfides2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Glial cells modulate retinal cell survival in rotenone-induced neural degeneration.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Glutathione Trisulfide Prevents Lipopolysaccharide-induced Inflammatory Gene Expression in Retinal Pigment Epithelial Cells2020

Author(s)

TAWARAYAMA HIROSHI 俵山寛司

TAWARAYAMA Hiroshi 俵山寛司