FUJIWARA Masachika 藤原正親

Researcher Number	20407026
Other IDs
Affiliation (Current)	2025: 杏林大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2020 – 2024: 杏林大学, 医学部, 教授 2016 – 2019: 杏林大学, 医学部, 准教授 2012 – 2015: 杏林大学, 医学部, 講師 2007 – 2008: 杏林大学, 医学部, 助教
Review Section/Research Field	Except Principal Investigator Respiratory surgery / Sections That Are Subject to Joint Review: Basic Section90130:Medical systems-related , Basic Section90140:Medical technology assessment-related / Basic Section 90140:Medical technology assessment-related / Basic Section 90130:Medical systems-related / Human pathology / Experimental pathology
Keywords	Except Principal Investigator 次世代シーケンス / 肺癌 / 人工臓器 / 肺移植 / ECMO / 人工肺 / 長期呼吸補助 / NGSパネル / がん関連遺伝子 / 重複癌 … More / 多発癌 / ゲノム編集 / メダカ / 発がん実験 / in vivo発がん実験 / Germline変異 / 家族性肺がん / 付加変異 / germline変異 / TP53 R248W / EGFR L858R / EGFR V843I / 遺伝性肺癌 / 家族性肺癌 / 先制医療 / 早期発見早期治療 / 予後予測 / TP53変異 / 発がんリスク / EGFR germline変異 / 肺がん / 分子シミュレーション / プロテオミクス / 遺伝子変異導入細胞 / 遺伝子改変マウス / 全ゲノムシーケンス / 遺伝性肺癌症候群 / EGFR V843I germline変異 / 小細胞癌 / 分子病理学 / 人体病理学 / POU / 転写因子 / 分化形質 / カルチノイド腫瘍 / 大細胞神経内分泌癌 / 小細胞肺癌 / 神経内分泌癌 / 生殖細胞 / 病理学 / 核酸 / B1 / hnRNP A2 / テロメア / 癌 Less

Optimizing biocompatibilities of an artificial lung in a setting of a long-term pulmonary artery-left atrium (PA-LA) extracorporeal circulation system
- Principal Investigator
  
  安樂真樹
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 90130:Medical systems-related
  Basic Section 90140:Medical technology assessment-related
  Sections That Are Subject to Joint Review: Basic Section90130:Medical systems-related , Basic Section90140:Medical technology assessment-related
- Research Institution
  Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology
fundamental research for the development of germline mutation diagnosis enabling preemptive medicine for lung cancer
- Principal Investigator
  
  Ohtsuka Kouki
- Project Period (FY)
  2017 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory surgery
- Research Institution
  Kyorin University
Clinical and molecular biological study of hereditary lung cancer caused by EGFR germline mutation
- Principal Investigator
  
  Ohtsuka Kouki
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory surgery
- Research Institution
  Kyorin University
Molecular pathological analyses of proneural/neuroendocrine phenotype-obtaining mechanisms on lung cancer cells
- Principal Investigator
  
  YAZAWA Takuya
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Chiba University
  Kyorin University
Comparative analysis of hnRNP A2/B1 isoform proteins to clarify the telomeric paradox in cancer cells
- Principal Investigator
  
  KAMMA Hiroshi
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Kyorin University

All 2019 2014 2013 2012 2008 2007

All Journal Article Presentation

[Journal Article] Predisposition to lung adenocarcinoma in a family harboring the germline EGFR V843I mutation.2019
- Author(s)
  Ohtsuka K, Ohnishi H, Fujiwara M, Morii T, Matsushima S, Ogura W, Yamasaki S, Kishino T, Tanaka R, Watanabe T
- Journal Title
  
  JCO Precision Oncology
  
  Volume: - Issue: 3 Pages: 1-4
- DOI
  10.1200/po.19.00104
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K01439, KAKENHI-PROJECT-17K10799
[Journal Article] Expression of developing neural transcription factors in lung carcinoid tumors2014
- Author(s)
  Endo T, Yazawa T, Shishido-Hara Y, FUjiwara M, Shimoyamada H, Ishii J, Sato H, Tachibana K, Takei H, Kondo H, Goya T, Endo S, Kamma H
- Journal Title
  
  Pathology International
  
  Volume: 64 Issue: 8 Pages: 365-374
- DOI
  10.1111/pin.12183
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24590428
[Journal Article] POU domain transcription factor BRN2 is crucial for expression of ASCL1, ND1 and neuroendocrine marker molecules and cell growth in small cell lung cancer2013
- Author(s)
  Ishii J, Sato H, et al.
- Journal Title
  
  Pathology International
  
  Volume: 63 Issue: 3 Pages: 158-168
- DOI
  10.1111/pin.12042
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790361, KAKENHI-PROJECT-24500421, KAKENHI-PROJECT-24590428
[Journal Article] Neural lineage-specific homeoprotein BRN2 is directly involved in TTF1 expression in small-cell lung cancer2013
- Author(s)
  Sakaeda M, Sato H, et al.
- Journal Title
  
  Laboratory Investigation
  
  Volume: 93 Issue: 4 Pages: 408-421
- DOI
  10.1038/labinvest.2013.2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790361, KAKENHI-PROJECT-24500421, KAKENHI-PROJECT-24590428
[Journal Article] Decreased expression of the thyroid-stimulating hormone receptor in poorly-differentiated carcinoma of the thyroid2008
- Author(s)
  Matsumoto H, Sakamoto A, Fujiwara M, Yano Y, Shishido-Hara Y, Fujioka Y & Kamma H
- Journal Title
  
  Oncol Rep. 19
  
  Pages: 1405-1411
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590403
[Journal Article] Cyclic AMP-mediated growth suppression and MAPK phosphorylation in thyroid papillary carcinoma cells2008
- Author(s)
  Matsumoto M, Sakamoto A, Fujiwara M, Yano Y, Shishido-Hara Y, Fujioka Y, Kamma H
- Journal Title
  
  Molr Med Rep. 1
  
  Pages: 245-249
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590403
[Journal Article] WHO乳癌組織分類とわが国の乳癌取扱い規約分類の相違点2007
- Author(s)
  菅間博, 寺戸雄一, 藤原正親
- Journal Title
  
  臨床検査 51(1)
  
  Pages: 23-29
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590403
[Journal Article] Growth suppression of thyroid cancer cells by adenylcyclase activator2007
- Author(s)
  Yano Y, Kamma H, Matsumoto H, Fujiwara M, Bando H, Hara H, Yashiro T, Ueno E, Ito K, Uchida K
- Journal Title
  
  Oncol Rep. 18(2)
  
  Pages: 441-445
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590403
[Presentation] 肺の神経内分泌系悪性腫瘍とIII/IV型POU遺伝子2014
- Author(s)
  石井　順、矢澤卓也、佐藤華子、宍戸-原由紀子、平松千恵、下山田博明、藤原正親、菅間　博
- Organizer
  第103回日本病理学会総会
- Place of Presentation
  広島国際会議場（広島県・広島市）
- Year and Date
  2014-04-24
- Data Source
  KAKENHI-PROJECT-24590428
[Presentation] POU型転写因子BRN2は肺小細胞癌細胞の神経/神経内分泌形質発現および増殖活性に関与する2013
- Author(s)
  石井順、佐藤華子、榮田昌史、原由紀子、平松千恵、菅間博、下山田博明、藤原正親、遠藤哲哉、青木一郎、矢澤卓也
- Organizer
  第102回日本病理学会総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-24590428
[Presentation] 肺神経内分泌腫瘍におけるBRN2、ASCL1、TTF1の発現性の検討2013
- Author(s)
  遠藤哲哉、石井順、榮田昌史、藤原正親、宍戸-原由紀子、下山田博明、平野和彦、寺戸雄一、菅間博、矢澤卓也
- Organizer
  第102回日本病理学会総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-24590428
[Presentation] 肺小細胞癌におけるTTF-1発現はPOUドメイン転写因子BRN2により直接的に制御されている2013
- Author(s)
  榮田昌史、佐藤華子、石井順、菅間博、原由紀子、平松千恵、下山田博明、藤原正親、遠藤哲哉、矢澤卓也
- Organizer
  第102回日本病理学会総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-24590428
[Presentation] 肺癌の神経／神経内分泌形質にASCL1およびRESTが与える影響の解析2012
- Author(s)
  石井順、有益優、榮田昌史、柏木維人、下山田博明、佐藤華子、宮田千恵、藤原正親、菅間博、青木一郎、矢澤卓也
- Organizer
  第101日本病理学会総会
- Place of Presentation
  新宿、東京都
- Data Source
  KAKENHI-PROJECT-24590428
[Presentation] 腎盂癌に合併した微小パラガングリオーマの一例2007
- Author(s)
  菅間博、藤原正親、原由紀子、坂本穆彦、木村伯子
- Organizer
  第11回日本内分泌病理学会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-19590403

1. KAMMA Hiroshi (10195191)

# of Collaborated Projects: 2 results

# of Collaborated Products: 11 results
2. Ohtsuka Kouki (70439165)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. 渡邊卓 (00191768)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. 松島早月 (80231596)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. 大西宏明 (80291326)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. YAZAWA Takuya (50251054)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
7. SATO Hanako (60438132)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
8. HARA Yukiko (40313267)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
9. SHIMOYAMADA Hiroaki (60381472)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
10. 横山琢磨 (50439197)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 田中良太 (40415063)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 安樂真樹 (70598557)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 磯山隆 (20302789)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 小野稔 (40270871)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 豊田雅士 (50392486)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. ISHII Jun

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
17. SAKAEDA Masashi

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
18. MORI Hideaki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 岸野智則

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

FUJIWARA Masachika 藤原 正親

Research Projects

Research Products

Co-Researchers

Optimizing biocompatibilities of an artificial lung in a setting of a long-term pulmonary artery-left atrium (PA-LA) extracorporeal circulation system

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

fundamental research for the development of germline mutation diagnosis enabling preemptive medicine for lung cancer

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Clinical and molecular biological study of hereditary lung cancer caused by EGFR germline mutation

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular pathological analyses of proneural/neuroendocrine phenotype-obtaining mechanisms on lung cancer cells

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Comparative analysis of hnRNP A2/B1 isoform proteins to clarify the telomeric paradox in cancer cells

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Predisposition to lung adenocarcinoma in a family harboring the germline EGFR V843I mutation.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Expression of developing neural transcription factors in lung carcinoid tumors2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] POU domain transcription factor BRN2 is crucial for expression of ASCL1, ND1 and neuroendocrine marker molecules and cell growth in small cell lung cancer2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Neural lineage-specific homeoprotein BRN2 is directly involved in TTF1 expression in small-cell lung cancer2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Decreased expression of the thyroid-stimulating hormone receptor in poorly-differentiated carcinoma of the thyroid2008

Author(s)

Journal Title

Data Source

[Journal Article] Cyclic AMP-mediated growth suppression and MAPK phosphorylation in thyroid papillary carcinoma cells2008

Author(s)

Journal Title

Data Source

[Journal Article] WHO乳癌組織分類とわが国の乳癌取扱い規約分類の相違点2007

Author(s)

Journal Title

Data Source

[Journal Article] Growth suppression of thyroid cancer cells by adenylcyclase activator2007

Author(s)

Journal Title

Data Source

[Presentation] 肺の神経内分泌系悪性腫瘍とIII/IV型POU遺伝子2014

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] POU型転写因子BRN2は肺小細胞癌細胞の神経/神経内分泌形質発現および増殖活性に関与する2013

Author(s)

Organizer

Place of Presentation

FUJIWARA Masachika 藤原正親