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Kumagai Ayako  熊谷 彩子

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KUMAGAI Ayako  熊谷 彩子

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Researcher Number 20455869
Affiliation (Current) 2025: 国立研究開発法人医薬基盤・健康・栄養研究所, 医薬基盤研究所 代謝疾患関連タンパク探索プロジェクト, 協力研究員
Affiliation (based on the past Project Information) *help 2013: 独立行政法人医薬基盤研究所, 創薬基盤研究部, 特任研究員
Review Section/Research Field
Except Principal Investigator
Pathological medical chemistry
Keywords
Except Principal Investigator
認知症 / 活性酸素 / 化合物 / 神経 / cAMPシグナル / CRTC1 / 阻害剤 / フラボノイド / 神経保護 / 転写 / CREB / SIK
  • Research Projects

    (1 results)
  • Research Products

    (19 results)
  • Co-Researchers

    (5 People)
  •  Mechanisms and applications of SIK2-regulation for neuro-protection

    • Principal Investigator
      TAKEMORI Hiroshi
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      独立行政法人医薬基盤研究所

All 2013 2012 2011 Other

All Journal Article Presentation Patent

  • [Journal Article] Induction of melanogenesis by 4'-O-methylated flavonoids in B16F10 melanoma cells2013

    • Author(s)
      Horibe I, Satoh Y, Shiota Y, Kumagai A, Horike N, Takemori H, Uesato S, Sugie S, Obata K, Kawahara H, Nagaoka Y
    • Journal Title

      J Nat Med

      Volume: 67 Pages: 705-10

    • Data Source
      KAKENHI-PROJECT-23390082
  • [Journal Article] Induction of melanogenesis by 4'-O-methylated flavonoids in B16F10 melanoma cells.2013

    • Author(s)
      Horibe I., Satoh Y., Shiota Y., Kumagai A., Horike N., Takemori H., Uesato S., Sugie S., Obata K., Kawahara H., Nagaoka Y
    • Journal Title

      J Nat Med.

      Volume: 67 Pages: 705-710

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390082
  • [Journal Article] Involvement of SIK3 in glucose and lipid homeostasis in mice2012

    • Author(s)
      Uebi T, Itoh Y, Hatano O, Kumagai A, Sanosaka M, Sasaki T, Sasagawa S, Doi J, Tatsumi K, Mitamura K, Morii M, Aozasa K, Kawamura T, Okumura M, Nakae J, Takikawa H, Fukusato T, Koura M, Nish M, Hamsten A, Silveiral A, Bertorellol AM, Kitagawa K, Nagaoka Y, Kawahara H, Tomonaga T, Naka T, Ikegawa S, Tsumaki N, Matsuda J, Takemori H
    • Journal Title

      PLoS ONE

      Volume: e7(in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390082
  • [Journal Article] Involvement of SIK3 in glucose and lipid homeostasis in mice2012

    • Author(s)
      Uebi T, Itoh Y, Hatano O, Kumagai A, Sanosaka M, Sasaki T, Sasagawa S, Doi J, Tatsumi K, Mitamura K, Morii E, Aozasa K, Kawamura T, Okumura M, Nakae J, Takikawa H, Fukusato T, Koura M, Nish M, Hamsten A, Silveira A, Bertorello AM, Kitagawa K, Nagaoka Y, Kawahara H, Tomonaga T, Naka T, Ikegawa S, Tsumaki N, Matsuda J, Takemori H
    • Journal Title

      PLoS One

      Volume: 7

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390082
  • [Journal Article] A potent inhibitor of SIK2, 3,3',7-trihydroxy-4'-methoxyflavon (4'-O-methylfisetin), promotes melanogenesis in B16F10 melanoma cells2011

    • Author(s)
      Kumagai A, Horike N, Satoh Y, Uebi T, Sasaki T, Itoh Y, Hirata Y, Uchio-Yamada K, Kitagawa K, Uesato S, Kawahara H, Takemori H, Nagaoka Y
    • Journal Title

      PLoS ONE

      Volume: 6

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390082
  • [Journal Article] A potent inhibitor of SIK2, 3, 3', 7-trihydroxy-4'-methoxyflavon (4'-O-methylfisetin), promotes melanogenesis in B16F10 melanoma cells2011

    • Author(s)
      Kumagai A, Horike N, Satoh Y, Uebi T, Sasaki T, Itoh Y, Hirata Y, Uchio-Yamada K, Kitagawa K, Uesato S, Kawahara H, Takemori H Nagaoka Y
    • Journal Title

      PLoS One

      Volume: 6

    • Data Source
      KAKENHI-PROJECT-23390082
  • [Patent] チロシナーゼ誘導抑制剤及びメラニン合成抑制剤2012

    • Inventor(s)
      竹森 洋, 熊谷彩子, 森田純子, 渕野裕之, 川原信夫, 飯田 修, 杉村康司, 志賀幸生, 鎌田 文広, 香月茂樹, 河原秀久, 長岡康夫
    • Industrial Property Rights Holder
      株式会社桃谷順天館
    • Industrial Property Rights Type
      特許
    • Filing Date
      2012-11-24
    • Data Source
      KAKENHI-PROJECT-23390082
  • [Patent] チロシナーゼ誘導抑制剤及びメラニン合成抑制剤2012

    • Inventor(s)
      竹森洋、熊谷彩子、森田純子
    • Industrial Property Rights Holder
      株式会社桃谷順天館
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2012-249917
    • Filing Date
      2012-11-14
    • Data Source
      KAKENHI-PROJECT-23390082
  • [Presentation] Effects of Pterosin B from Pteridium Aquilinum on the blood glucose level in db/db mice.2013

    • Author(s)
      Ito Y., Sanosaka M., Kumagai A., Takemori H., Fuchino H., Kawahara N., Doi J., Ota M.
    • Organizer
      The EMBO meeting
    • Place of Presentation
      Amsterdam
    • Data Source
      KAKENHI-PROJECT-23390082
  • [Presentation] Effects of Pterosin B from Pteridium Aquilinum on the blood glucose level in db/db mice2013

    • Author(s)
      Ito Y, Sanosaka M, Kumagai A, Takemori H, Fuchino H, Kawahara N, Doi J, Ota M
    • Organizer
      The EMBO meeting
    • Place of Presentation
      AMSETDAM
    • Year and Date
      2013-09-22
    • Data Source
      KAKENHI-PROJECT-23390082
  • [Presentation] SIK3 regulates pro-inflammatroy cytokine expression in mouse macrophage.2013

    • Author(s)
      Sanosaka M., Fujimoto M., Ohkawara T., Ito Y., Kumagai A., Naka T., Takemori H.
    • Organizer
      2013 ASCB Annual Meeting
    • Place of Presentation
      New Orleans
    • Data Source
      KAKENHI-PROJECT-23390082
  • [Presentation] 塩誘導性キナーセ SIK3 はコレステロール,胆汁酸代謝に重要である2012

    • Author(s)
      伊東祐美,上尾達也,熊谷彩子,竹森 洋,土居純子
    • Organizer
      第66回日本栄養食料学会
    • Place of Presentation
      仙台
    • Year and Date
      2012-05-19
    • Data Source
      KAKENHI-PROJECT-23390082
  • [Presentation] 塩誘導性キナーゼ 2 (SIK2)の新規メラニン合成調節機構について2012

    • Author(s)
      熊谷彩子,堀家なな緒,伊東祐美,長岡康夫,竹森 洋
    • Organizer
      第85回日本生化学会
    • Place of Presentation
      福岡
    • Year and Date
      2012-12-16
    • Data Source
      KAKENHI-PROJECT-23390082
  • [Presentation] SIK3 によるクラスII-HDAC 制御がコレステロール-胆汁酸代謝へ与える影響2012

    • Author(s)
      伊東祐美,佐野坂真人,熊谷彩子,竹森洋
    • Organizer
      第85回日本生化学会
    • Place of Presentation
      福岡
    • Year and Date
      2012-12-16
    • Data Source
      KAKENHI-PROJECT-23390082
  • [Presentation] 塩誘導性キナーゼSIK3はコレステロールのクリアランスを制御する2011

    • Author(s)
      伊東祐美、上尾達也、熊谷彩子、竹森洋
    • Organizer
      第84回日本生化学会
    • Place of Presentation
      国立京都国際会館(京都)
    • Year and Date
      2011-09-23
    • Data Source
      KAKENHI-PROJECT-23390082
  • [Presentation] 塩誘導性キナーゼSIK3-KOマウスに観察される胆汁うっ滞2011

    • Author(s)
      竹森洋、上尾達也、伊東祐美、熊谷彩子、佐野坂真人
    • Organizer
      第33回胆汁酸研究会
    • Place of Presentation
      大阪ガーデンパレス(大阪)
    • Year and Date
      2011-11-19
    • Data Source
      KAKENHI-PROJECT-23390082
  • [Presentation] 塩誘導性キナーゼSIK3はコレステロールのクリアランスを制御する2011

    • Author(s)
      伊東祐美、上尾達也、熊谷彩子、竹森洋、土居純子
    • Organizer
      第50回日本栄養食糧学会・近畿支部大会
    • Place of Presentation
      近畿大学(奈良)
    • Year and Date
      2011-10-15
    • Data Source
      KAKENHI-PROJECT-23390082
  • [Presentation] SIK3はコレステロール-胆汁酸代謝の制御因子である-2011

    • Author(s)
      上尾達也, 伊東裕美, 熊谷彩子, 竹森洋
    • Organizer
      第34回日本分子生物学会
    • Place of Presentation
      パシフィコ横浜(神奈川)
    • Year and Date
      2011-12-16
    • Data Source
      KAKENHI-PROJECT-23390082
  • [Presentation] 塩誘導性キナーゼ 2 (SIK2)の新規メラニン合成調節機構について

    • Author(s)
      熊谷彩子
    • Organizer
      第85回日本生化学会
    • Place of Presentation
      福岡
    • Data Source
      KAKENHI-PROJECT-23390082
  • 1.  TAKEMORI Hiroshi (90273672)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 16 results
  • 2.  HATANO Osamu (40164850)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 3.  KITAGAWA Kazuo (70301257)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 4 results
  • 4.  NAGAOKA Yasuo (90243039)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 7 results
  • 5.  田端 俊英 (80303270)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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