NAGAOKA Yasuo 長岡康夫

Researcher Number	90243039
Other IDs
External Links
Affiliation (Current)	2022: 関西大学, 化学生命工学部, 教授
Affiliation (based on the past Project Information) *help	2009 – 2017: Kansai University, 化学生命工学部, 教授 2011 – 2015: 関西大学, 工学部, 教授 2007 – 2008: Kansai University, 化学生命工学部, 准教授 2001 – 2005: 関西大学, 工学部, 助教授 2000: 京都大学, 薬学研究科, 助手 … More
Review Section/Research Field	Principal Investigator Drug development chemistry / Chemical pharmacy / Bioorganic chemistry / Chemical pharmacy Except Principal Investigator Chemical pharmacy / Bioorganic chemistry / Synthetic chemistry / Synthetic chemistry / Pathological medical chemistry / Neurology / 広領域 / Living organism molecular science / Applied pharmacology
Keywords	Principal Investigator HDAC / ヒストン脱アセチル化酵素阻害剤 / ヒストン脱アセチル化酵素 / ナノ粒子 / プロドラッグ / トリコスポリン / ペプタイボール / イオンチャンネル / 共役付加反応 / 環化反応 … More Except Principal Investigator 共役付加反応 / イミン / リチウムエノラート / conjugate addition / lithium enolate / イオンチャンネル / ペプタイボール / カテコールアミン / 共役付加 / 抗タキソールモノクローナル抗体 / タキソール / モノクローナル抗体 / CREB / 脳虚血 / パーキンソン病 / 低分子化合物 / 植物培養細胞 / ダイベンゾパラダイオキシン / plant cultured cell / 不斉合成 / 触媒 / β-ラクタム / 有機銅 / 立体選択性 / 反応面 / 求核付加反応 / 不斉補助剤 / catalytic reaction / 不斉配位子 / リチウムチオラート / P388 / p21 / WAF1 / neu / SKBR3 / Herceptin / 抗生ペプチド / 両親媒性ペプチド / 副腎髄質細胞 / 人工脂質二分子膜 / トリコデルマ・ビリデ / 情報伝達 / 抗菌性ペプチド / 生体膜 / 人工膜 / アルケニルホスナート / 還化反応 / 不斉ホスフィン配位子 / 不斉アリル化 / アルケニルホスホナート / 炭素求核剤 / 窒素求核剤 / 脱水素反応 / 環化反応 / 共役付加環化反応 / ダブルマイケル反応 / 炭索求核剤 / 抗ビンブラスチンモノクローナル抗体 / ビンブラスチン / 反応場 / 立体選択的合成 / anhydrovinblastine / dihydropyridinium中間体 / ビンドリン / カサランチン / Baccatin III / 立体選択的反応 / 分子認識 / ハプテン / ハイブリドーマ / 抗体反応 / ニュートラルロスキャン / MS / MS法 / ニュートラルロススキャン / ニュートラルスキャン / SIK / 転写 / 神経保護 / フラボノイド / 阻害剤 / CRTC1 / ｃAMPシグナル / 神経 / 化合物 / 活性酸素 / 認知症 / シグナルトランスダクション / ＣＲＥＢ / ＳＩＫ（塩誘導性キナーゼ） / ＨＤＡＣ（ヒストン脱アセチル化酵素） / ＨＤＡＣ阻害剤 / 創薬 / CRTC / SIK（塩誘導性キナーゼ） / HDAC / アポトーシス / エピゲノム / TORC / 神経疾患 / 脳卒中 / 抗発癌促進物質 / アカネ科 / クワ科 / ノウゼンカズラ科 / テルペノイド / ナフトキノン / プレニルカルコン / 抗発癌プロモーション物質 / 芳香族化合物 / イリドイド / 生合成 / anti-tumor-promoting substance / Rubiaceae / Moraceae / Bignoniaceae / Terpenoid / naphthoquinone / prenylchalcone / ハロゲン化ダイベンゾパラダイオキシン / ビスベンジルイソキノリンアルカロイド / 発癌 / 抗発癌促進 / ダイオキシン / チアンスレン / 生物変換 / 抗発癌プロモーション / dibenzo-p-dioxin / hologenated dibenzo-p-dioxin / bisbenzylisoquinoline alkaloid / carcinogenesis / anti-tumar-promotion / dioxin / thianthrene / LUMO係数 / 配位子 / 錯体 / ホスフィン / 配座変換 / enantioselective reaction / imine / LUMO coefficients / ligand / beta-lactam / チオフェノール / 炭素-イオウ結合 / 三成分錯体 / リチウムアミド / 付加反応 / chiral ligand / lithiumthiolate / asymmetric reaction / 2-trimethylsilythiphenol / 人工イオンチャンネル / ペプチドバンドル / トリコデルマポリスポーラム / トリコスポリン / 電位依存性チャンネル / 不完全菌 / バレルステーブモデル / artificial ion channel / peptide bunndle / Trichoderma polysporum / trichosporin / peptaibol / voltage-dependent channel / imperfect fungus / barrel stave / 触媒的不斉合成反応 / キラルエーテル配位子 / キラルアミドホスフィン / ヘミレイバル配位子 / ピーターソン反応 / 3生分錯体 / 不斉エポキシ化 / 不斉反応 / 触媒的不斉反応 / ベータラクタム / 炭素-炭素結合 / 銅アミドホスフィン / 不斉プロトン化 / catalytic asymmetric reactions / chiral ligands / chiral ether ligands / chiral amidophosphine ligands / hemilabile ligands / lithium thiolate / ピストン脱アセチル化酵素 / ヒト正常繊維芽細胞Her2 / o-アミノチオフェノール / ヒストン脱アセチル化酸素阻害剤 / ヒト正常繊維芽細胞 / フッ素原子 / 血漿中安定性試験 / o-アミノチオフェノール誘導体 / Her2高発現型乳癌細胞 / ハーセプチン / ヒストン脱アセチル化酵素阻害剤 / P388担癌マウス実験 / HCT116 / SK-BR-3 / 細胞周期停止 / Her2高発現型乳がん細胞 / 緑茶カテキン / Her / HT-29 / SW620 / (-)-epigallocatechin gallate / (-)-epigallocatechin / 抗がん剤 / histone deacetylase / human normal fibroblast cell / Her2 / o-aminothiophenol / PPI阻害剤 / p53 / MDM2 / MDMX / 神経細胞 / 血管内皮 / 血管内皮細胞 / 血液脳関門 / 蛋白相互作用阻害剤 / 神経保護剤 / 脳神経疾患 / 蛋白質 / 蛋白蛋白相互作用 / 創薬化学 / トランスレーショナルリサーチ Less

Novel therapy for neurological disorders by protein-protein interaction inhibitor
- Principal Investigator
  
  SASAKI Tsutomu
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Applied pharmacology
- Research Institution
  Osaka University
Development of formulation for gene therapy utilizing epigenetic effect of HDAC inhibitorsPrincipal Investigator
- Principal Investigator
  
  Nagaoka Yasuo
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  Kansai University
The role and mechanisms of TORC and HDAC signaling pathway and therapeutic new-class small compounds for neurological disease
- Principal Investigator
  
  sasaki tsutomu
- Project Period (FY)
  2012 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurology
- Research Institution
  Osaka University
Development of PEGylated Histone Deacetylase Inhibitor Having Prolonged Blood Retention and EPR effectPrincipal Investigator
- Principal Investigator
  
  NAGAOKA Yasuo
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  Kansai University
Mechanisms and applications of SIK2-regulation for neuro-protection
- Principal Investigator
  
  TAKEMORI Hiroshi
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  独立行政法人医薬基盤研究所
Development of cationic histone deacetylase inhibitors as enhancer of gene transfection and expressionPrincipal Investigator
- Principal Investigator
  
  NAGAOKA Yasuo
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  Kansai University
Attempted synthesis of taxol utilizing anti-taxol monoclonal antibody as a as a chiral mould
- Principal Investigator
  
  UESATO Shinichi
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Synthetic chemistry
- Research Institution
  Kansai University
Synthesis of Histone Deacetylase Inhibitors Toward the Development of DDSPrincipal Investigator
- Principal Investigator
  
  NAGAOKA Yasuo
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  Kansai University
Design of the anti-tumor agents targeting the functional proteins involved in cancer cell growth
- Principal Investigator
  
  UESATO Shinichi
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Living organism molecular science
- Research Institution
  Kansai University
Development of asymmetric syntheses and valuable bioactive compounds based on alkenylphosphonatesPrincipal Investigator
- Principal Investigator
  
  IWAKI Hiroaki, 長岡康夫
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Kansai University
モノクローナル抗体を反応場として用いた天然抗がん剤の新規合成法の開発
- Principal Investigator
  
  UESATO Shinichi
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Synthetic chemistry
- Research Institution
  Kansai University
Development of reactions based on addition of electrophiles to methylenebisphosphonatesPrincipal Investigator
- Principal Investigator
  
  NAGAOKA Yasuo
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Kansai University
  Kyoto University
アルケニルホスホナートを捕捉剤とする炭素及び窒素求核剤の反応開発
- Principal Investigator
  
  TOMIOKA Kiyoshi
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Chemical pharmacy
- Research Institution
  Kyoto University
チオールの触媒的不斉共役付加反応を契機とする連続不斉点構築法の開拓Principal Investigator
- Principal Investigator
  
  長岡康夫
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Kyoto University
Development of Catalytic Enantioselective Reactions Based on the Activation Technology by Chiral Ligands
- Principal Investigator
  
  TOMIOKA Kiyoshi
- Project Period (FY)
  1998 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Chemical pharmacy
- Research Institution
  KYOTO UNIVERSITY
脂質二分子膜中で安定に存在するイオンチャンネルの構築Principal Investigator
- Principal Investigator
  
  長岡康夫
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Kyoto University
Origin of Regio and Stereoselectivity in Conjugate Addition Reactions
- Principal Investigator
  
  TOMIOKA Kiyoshi
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Chemical pharmacy
- Research Institution
  KYOTO UNIVERSITY
  Osaka University
Catalytic Asymmetric Synthesis of Bioactive Molecules
- Principal Investigator
  
  TOMIOKA Kiyoshi
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Chemical pharmacy
- Research Institution
  KYOTO UNIVERSITY
  Osaka University
Design, structures and functions of stabilized artificial ion channels
- Principal Investigator
  
  IIDA Akira
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bioorganic chemistry
- Research Institution
  KYOTO UNIVERSITY
セルラーゼ生産菌より得られた抗菌性ペプチドの情報伝達機構
- Principal Investigator
  
  IIDA Akira
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Bioorganic chemistry
- Research Institution
  Kyoto University
脂質2分子膜及び神経細胞に対するトリコスポリン類のチャンネル形成機構に関する研究Principal Investigator
- Principal Investigator
  
  長岡康夫
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Bioorganic chemistry
- Research Institution
  Kyoto University
チャンネル形成抗生物質ペプタイボール類の生体・人工膜との相互作用
- Principal Investigator
  
  藤多哲朗
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Kyoto University
Biolgical activity of dibenzop-dioxin derivatives and their biological degradation compounds
- Principal Investigator
  
  UEDA Shinichi
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  広領域
- Research Institution
  KYOTO UNIVERSITY
Production of Anti-tumor Compounds and Degradation of Carcinogenic Compounds
- Principal Investigator
  
  UEDA Shinichi
- Project Period (FY)
  1992 – 1994
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  Chemical pharmacy
- Research Institution
  KYOTO UNIVERSITY

[Book] Modern Allene Chemistry, Chiral allene synthesis. (ed. Norbert Krause.)2004
- Author(s)
  H.Ohno, Y.Nagaoka, K.Tomioka
- Total Pages
  710
- Publisher
  Wiley
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590031
[Journal Article] The Importance of 11alpha-OH, 15-oxo, and 16-en Moieties of 11α-Hydroxy-15-oxo-kaur-16-en-19-oic Acid in Its Inhibitory Activity on Melanogenesis2017
- Author(s)
  Kuroi Azusa、Sugimura Koji、Kumagai Ayako、Kohara Arihiro、Nagaoka Yasuo、Kawahara Hidehisa、Yamahara Minori、Kawahara Nobuo、Takemori Hiroshi、Fuchino Hiroyuki
- Journal Title
  
  Skin Pharmacology and Physiology
  
  Volume: 30 Pages: 205-215
- DOI
  10.1159/000475471
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K08035
[Journal Article] Callicarpa longissima extract, carnosol-rich, potently inhibits melanogenesis in B16F10 melanoma cells.2016
- Author(s)
  M. Yamahara, K. Sugimura, A. Kumagai, H. Fuchino, A. Kuroi, M. Kagawa, Y. Itoh, H. Kawahara, Y. Nagaoka, O. Iida, N. Kawahara, H. Takemori, H. Watanabe
- Journal Title
  
  J Nat Med
  
  Volume: 70 Pages: 28-35
- DOI
  10.1007/s11418-015-0933-5
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K08035, KAKENHI-PROJECT-25293096
[Journal Article] Simple chronic colitis model using hypopigmented mice with a Hermansky-Pudlak syndrome 5 gene mutation2016
- Author(s)
  Y. Itoh, Y. Nagaoka, Y. Katakura, H. Kawahara and H. Takemori
- Journal Title
  
  Pigment Cell Melanoma Res.
  
  Volume: 29 Pages: 578-582
- DOI
  10.1111/pcmr.12504
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08035
[Journal Article] Influence of the carbamate fungicide benomyl on the gene expression and activity of aromatase in the human breast carcinoma cell line MCF-72015
- Author(s)
  Yasuyuki Kawaratani , Takeshi Matsuoka , Yoshiyuki Hirata , Naofumi Fukata , Yasuo Nagaoka , Shinichi Uesato
- Journal Title
  
  Environmental Toxicology and Pharmacology
  
  Volume: 39 Pages: 292-299
- DOI
  10.1016/j.etap.2014.11.032
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24590152
[Journal Article] Synergistic Antitumor Effect of a Combination of Paclitaxel and Carboplatin with Nobiletin from Citrus depressa on Non-Small-Cell Lung Cancer Cell Lines2014
- Author(s)
  S. Uesato, H. Yamashita, R. Maeda, Y. Hirata, M. Yamamoto, S. Matsue, Y. Nagaoka, M. Shibano, M. Taniguchi, K. Baba, M. Ju-Ichi
- Journal Title
  
  Planta. Med.
  
  Volume: 80 Pages: 452-457
- DOI
  10.1055/s-0034-1368321
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590152
[Journal Article] Altered actions of memantine and NMDA-induced currents in new Grid2-deleted mouse line2014
- Author(s)
  Ayako Kumagai, Akira Fujita, Tomoki Yokoyama, Yuki Nonobe, Yasuhiro Hasaba, Tsutomu Sasaki, Yumi Itoh, Minako Koura, Osamu Suzuki, Shigeki Adachi, Haruko Ryo, Arihiro Kohara, Lokesh P. Tripathi, Masato Sanosaka, Toshiki Fukushima, Taisei Nomura, Hiroshi Takemori, et al.
- Journal Title
  
  Genes (Basel).
  
  Volume: 5 Pages: 1095-1114
- DOI
  10.3390/genes5041095
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-23241023, KAKENHI-PROJECT-25430186, KAKENHI-PROJECT-25670155, KAKENHI-PROJECT-25740023, KAKENHI-PROJECT-26430012, KAKENHI-PROJECT-26670196, KAKENHI-PROJECT-24390222
[Journal Article] Induction of melanogenesis by 4'-O-methylated flavonoids in B16F10 melanoma cells2013
- Author(s)
  I. Horibe, Y. Satoh, Y. Shiota, A. Kumagai, N. Horike, H. Takemori, S. Uesato, S. Sugie, K. Obata, H. Kawahara, Y. Nagaoka.
- Journal Title
  
  J. Nat. Med.
  
  Volume: 67 Pages: 705-710
- DOI
  10.1007/s11418-012-0727-y
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590152
[Journal Article] Induction of melanogenesis by 4'-O-methylated flavonoids in B16F10 melanoma cells.2013
- Author(s)
  Horibe I., Satoh Y., Shiota Y., Kumagai A., Horike N., Takemori H., Uesato S., Sugie S., Obata K., Kawahara H., Nagaoka Y
- Journal Title
  
  J Nat Med.
  
  Volume: 67 Pages: 705-710
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390082
[Journal Article] Induction of melanogenesis by 4'-O-methylated flavonoids in B16F10 melanoma cells2013
- Author(s)
  Horibe I, Satoh Y, Shiota Y, Kumagai A, Horike N, Takemori H, Uesato S, Sugie S, Obata K, Kawahara H, Nagaoka Y
- Journal Title
  
  J Nat Med
  
  Volume: 67 Pages: 705-10
- Data Source
  KAKENHI-PROJECT-23390082
[Journal Article] Anti-tumor activity of new orally bioavailable 2-amino-5-(thiophen-2-yl) benzamide-series histone deacetylase inhibitors, possessing an aqueous soluble functional group as a surface recognition domain2012
- Author(s)
  Y. Hirata, M. Hirata, Y. Kawaratani, M. Shibano, M. Taniguchi, M. Yasuda, Y. Ohmomo, Y. Nagaoka, K. Baba, S. Uesato
- Journal Title
  
  Bioorg. Med. Chem. Lett
  
  Volume: 22(5) Pages: 1926-1930
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590131
[Journal Article] Anti-tumor activity of new orally bioavailable 2-amino-5-(thiophen-2-yl)benzamide-series histone deacetylase inhibitors, possessing an aqueous soluble functional group as a surface recognition domain2012
- Author(s)
  Y. Hirata, M. Hirata, Y. Kawaratani, M. Shibano, M. Taniguchi, M. Yasuda, Y. Ohmomo, Y. Nagaoka, K. Baba, S. Uesato
- Journal Title
  
  Bioorg. Med. Chem. Lett.
  
  Volume: 22 Pages: 1926-1930
- DOI
  10.1016/j.bmcl.2012.01.053
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590152
[Journal Article] Involvement of SIK3 in glucose and lipid homeostasis in mice2012
- Author(s)
  Uebi T, Itoh Y, Hatano O, Kumagai A, Sanosaka M, Sasaki T, Sasagawa S, Doi J, Tatsumi K, Mitamura K, Morii M, Aozasa K, Kawamura T, Okumura M, Nakae J, Takikawa H, Fukusato T, Koura M, Nish M, Hamsten A, Silveiral A, Bertorellol AM, Kitagawa K, Nagaoka Y, Kawahara H, Tomonaga T, Naka T, Ikegawa S, Tsumaki N, Matsuda J, Takemori H
- Journal Title
  
  PLoS ONE
  
  Volume: e7(in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390082
[Journal Article] Involvement of SIK3 in glucose and lipid homeostasis in mice2012
- Author(s)
  Uebi T, Itoh Y, Hatano O, Kumagai A, Sanosaka M, Sasaki T, Sasagawa S, Doi J, Tatsumi K, Mitamura K, Morii E, Aozasa K, Kawamura T, Okumura M, Nakae J, Takikawa H, Fukusato T, Koura M, Nish M, Hamsten A, Silveira A, Bertorello AM, Kitagawa K, Nagaoka Y, Kawahara H, Tomonaga T, Naka T, Ikegawa S, Tsumaki N, Matsuda J, Takemori H
- Journal Title
  
  PLoS One
  
  Volume: 7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390082
[Journal Article] New microtubule polymerization inhibitors comprising a nitrooxymethylphenyl group. Bioorg2011
- Author(s)
  Y.Kawaratani, T.Harada, Y.Hirata, Y.Nagaoka, S.Uesato, 他5名
- Journal Title
  
  Med. Chem
  
  Volume: 19 Pages: 3995-4003
- DOI
  10.1016/j.bmc.2011.05.031
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590131, KAKENHI-PROJECT-23790090
[Journal Article] A potent inhibitor of SIK2, 3,3',7-trihydroxy-4'-methoxyflavon (4'-O-methylfisetin), promotes melanogenesis in B16F10 melanoma cells2011
- Author(s)
  Kumagai A, Horike N, Satoh Y, Uebi T, Sasaki T, Itoh Y, Hirata Y, Uchio-Yamada K, Kitagawa K, Uesato S, Kawahara H, Takemori H, Nagaoka Y
- Journal Title
  
  PLoS ONE
  
  Volume: 6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390082
[Journal Article] Antitumor effect of liposomal histone deacetylase inhibitor-lipid conjugates in vitro2011
- Author(s)
  Y. Hattori, Y. Nagaoka, M. Kubo, H. Yamasaku, Y. Ishii, S. Uesato, Y. Maitani
- Journal Title
  
  Chem. Pharm. Bull
  
  Volume: 59(11) Pages: 1386-1392
- NAID
  130001274814
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590131
[Journal Article] Antitumor Effect of Liposomal Histone Deacetylase Inhibitor-Lipid Conjugates in Vitro2011
- Author(s)
  Y.Hattori, Y.Nagaoka, Shinichi Uesato, 他4名
- Journal Title
  
  CHEMICAL & PHARMACEUTICAL BULLETIN
  
  Volume: 59 Issue: 11 Pages: 1386-1392
- DOI
  10.1248/cpb.59.1386
- NAID
  130001274814
- ISSN
  0009-2363, 1347-5223
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590131, KAKENHI-PROJECT-23790203
[Journal Article] A potent inhibitor of SIK2, 3, 3', 7-trihydroxy-4'-methoxyflavon (4'-O-methylfisetin), promotes melanogenesis in B16F10 melanoma cells2011
- Author(s)
  Kumagai A, Horike N, Satoh Y, Uebi T, Sasaki T, Itoh Y, Hirata Y, Uchio-Yamada K, Kitagawa K, Uesato S, Kawahara H, Takemori H Nagaoka Y
- Journal Title
  
  PLoS One
  
  Volume: 6
- Data Source
  KAKENHI-PROJECT-23390082
[Journal Article] Therapeutic Effect of Arctiin and Arctigenin in Immunocompetent and Immunocompromised Mice Infected with Influenza A Virus2010
- Author(s)
  K.Hayashi, K.Narutaki, Y.Nagaoka, T.Hayashi, S.Uesato
- Journal Title
  
  Biol.Pharm.Bull.
  
  Volume: 33 Pages: 1199-1205
- NAID
  130000300287
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590131
[Journal Article] Molecular bases of cyclodextrin adapter interactions with engineered protein nanopores2010
- Author(s)
  A.Banerjee, E.Mikhailova, S.Cheley, Li-Qun Gub, M.Montoyac, Y.Nagaoka, E.Gouaux, H.Bayley
- Journal Title
  
  Proc.Natl.Acad.Sci.USA
  
  Volume: 107 Pages: 8165-8170
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590131
[Journal Article] Histone Deacetylase Inhibitor Prodrugs in Nanoparticle Vector Enhanced Gene Expression in Human Cancer Cells Euro2009
- Author(s)
  Y. Ishii, Y. Hattori, T. Yamada, S. Uesato, Y. Maitani, Y. Nagaoka
- Journal Title
  
  J. Med. Chem
  
  Volume: 44(11) Pages: 4603-4610
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590131
[Journal Article] Histone deacetylase inhibitor prodrugs in nanoparticle vector enhancedgene expression in human cancer cells.2009
- Author(s)
  Ishii Y., Hattori Y., Yamada T., Uesato S, Maitani K., Nagaoka Y
- Journal Title
  
  Eur. J. Med. Chem 44
  
  Pages: 4603-4610
- Data Source
  KAKENHI-PROJECT-19550114
[Journal Article] Histone Deacetylase Inhibitor Prodrugs in Nanoparticle Vector Enhanced Gene Expression in Human Cancer Cells2009
- Author(s)
  Y.Ishii, Y.Hattori, T.Yamada, S.Uesato, Y.Maitani, Y.Nagaoka
- Journal Title
  
  Euro.J.Med.Chem. 44
  
  Pages: 4603-4610
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590131
[Journal Article] Histone deacetylase inhibitor prodrugs in nanoparticle vector enhanced gene expression in human cancer cells2009
- Author(s)
  Y.Ishii, Y.Hattori, T.Yamada, S.Uesato, Y.Maitani, Y.Nagaoka
- Journal Title
  
  Eur.J.Med.Chem. 44
  
  Pages: 4603-4610
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19550114
[Journal Article] Attempt to Detect Natural Anticancer Compounds - Protein Binding through Precursor Ion Scan and MS/MS Measurements.2008
- Author(s)
  J. Negishi, T. Shirahama, Y. Nagaoka, Y. Takemoto, S. Uesato.
- Journal Title
  
  J. Pharm. Soc. Japan 128
  
  Pages: 1317-1323
- NAID
  110006873990
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19550114
[Journal Article] Effects of Phosphorylation of Immunomodulatory Agent FTY720 (Fingolimod) on Antiproliferative Activity against Breast and Colon Cancer Cells2008
- Author(s)
  Yasuo Nagaoka, Kota Otsuki, Tetsuro Fujita, Shinichi Uesato
- Journal Title
  
  Biol Pharm. Bull. 31(6)
  
  Pages: 1177-1181
- NAID
  110006684337
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590110
[Journal Article] Effects of Phosphorylation of Immunomodulatory Agent FTY720 (Fingolimod)on Antiproliferative Activity against Breast and Colon Cancer Cells2008
- Author(s)
  Yasuo Nagaoka
- Journal Title
  
  Biol. Pharm. Bull. (印刷中)
- NAID
  110006684337
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590110
[Journal Article] Attempt to Detect Natural Anticancer Compounds-Protein Binding through Precursor Ion Scan and MS/MS Measurements2008
- Author(s)
  Negishi J., Shirahama T., Nagaoka Y., Takemoto Y., Uesato S
- Journal Title
  
  The Pharmaceutical Society of Japan 128
  
  Pages: 1317-1323
- NAID
  110006873990
- Data Source
  KAKENHI-PROJECT-19550114
[Journal Article] Pentide Backbone Mutagenesis of Putative Gating Hinges in a Potassium Ion Channel2008
- Author(s)
  Y. Nagaoka, L. Shang, A. Banerjee, H. Bayley, S. J. Tucker.
- Journal Title
  
  ChemBioChem 9
  
  Pages: 1725-1728
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590110
[Journal Article] Peptide Backbone Mutagenesis of Putative Gating Hinges in a Potassium Ion Channe2008
- Author(s)
  Yasuo Nagaoka, Lijun Shang, Arijit Banerjee, Hagan Bayley, and Stephen J. Tucker
- Journal Title
  
  ChemBioChem 9
  
  Pages: 1725-1728
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590110
[Journal Article] Synthesis and cancer antiproliferative activity of new histone deacetylase inhibitors : hydrophilic hydroxamates and 2-aminobenzamide-containing derivatives2006
- Author(s)
  Y.Nagaoka, et al.
- Journal Title
  
  Eur.J.Med.Chem. (in press)
- Data Source
  KAKENHI-PROJECT-15310154
[Journal Article] Synthesis and cancer antiproliferative activity of new histone deacehtylase inhibitors : hydrophilic hydroxamates and 2-aminobenzamide-contaning derivatives2006
- Author(s)
  Yasuo Nagaoka, et al.
- Journal Title
  
  Eur. J. Med. Chem. (印刷中)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15310154
[Journal Article] Synthesis and cancer antiproliferative activity of new histone deacetylase inhibitors : hydrophilic hydroxamates and 2-aminobenzamide-containing derivatives.2006
- Author(s)
  Yasuo Nagaoka, et al.
- Journal Title
  
  Eur.J.Med.Chem. (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15310154
[Journal Article] Tumor Chemopreventive Effect of Orally Administered (-)-Epigallocatechin and Its 3-O-Acylated Derivatives on the two stage Mouse Skin Carcinogenesis Induced by Peroxynitrate and 12-O-Tetradecanoylphorbol-13-acetate2005
- Author(s)
  Y.Nagaoka
- Journal Title
  
  Natural Medicines 59・1
  
  Pages: 49-51
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590031
[Journal Article] Inhibitory effect of cancer cell proliferation by novel histone deacetylase inhibitors involves p21/WAF1 induction and G2/M arrest.2005
- Author(s)
  T.Maeda, Y.Nagaoka, Y.Kawai, N.Takagaki, C.Yasuda, S.Yogosawa, Y.Sowa, T.Sakai, S.Uesato
- Journal Title
  
  Biol.Pharm.Bull. 28(5)
  
  Pages: 849-853
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590031
[Journal Article] Tumor chemopreventive effect of orally administered (-)-epigallocatechinand its 3-O-acylated derivatives on the two stage mouse skin carcinogenesis induced by peroxynitrite and 12-O-tetradecanoylphorbol-13-acetate.2005
- Author(s)
  Yasuo Nagaoka, et al.
- Journal Title
  
  Natural Medicine 59(1)
  
  Pages: 49-51
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15310154
[Journal Article] Effect of 3-O-Octanoyl-(+)-catechin on the Responses of GABAA Receptors and Na+/Glucose Cotransporters Expressed in Xenopus Oocytes and on the Oocyte Membrane Potential.2005
- Author(s)
  H.Aoshima, Y.Okita, S.J.Hossain, K.Fukue, M.Mito, Y.Orihara, T.Yokoyama, M.Yamada, A.Kumagai, Y.Nagaoka, S.Uesato, Y.Hara
- Journal Title
  
  Journal of Agricultural Food Chemistry 53
  
  Pages: 1955-1959
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590031
[Journal Article] Tumor chemopreventive effect of orally administered (-)-epigallocatechin and its 3-O-acylated derivatives on the two stage mouse skin carcinogenesis induced by peroxynitrite and 12-O-tetradecanoylphorbol- 13-acetate.2005
- Author(s)
  Yasuo Nagaoka, et al.
- Journal Title
  
  Natural Medicine 59(1)
  
  Pages: 49-51
- NAID
  110008732357
- Data Source
  KAKENHI-PROJECT-15310154
[Journal Article] Tumor chemopreventive effect of orally administered (-)-epigallocatechin and its 3-O-acylated derivatives on the two stage mouse skin carcinogenesis induced by peroxynitrite and 12-O-tetradecanoylphorbol-13-acetate.2005
- Author(s)
  Yasuo Nagaoka, et al.
- Journal Title
  
  Natural Medicine 59(1)
  
  Pages: 49-51
- NAID
  110008732357
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15310154
[Journal Article] Tumor Chemopreventive Effect of Orally Administered (-)-Epigallocatechin and Its 3-O-Acylated Derivatives on the two stage Mouse Skin Carcinogenesis Induced by peroxynitrate and 12-O-Tetradecanoylphorbol-13-acetae2005
- Author(s)
  Y.Nagaoka, A.Kumagai, Y.Tokuda, H.Nishino, S.Uesato
- Journal Title
  
  Natural Medicines 59(1)
  
  Pages: 49-51
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590031
[Journal Article] Potent Histone Deacetylase Inhibitors : N-hydroxybenzamides with Antitumor Activities.2004
- Author(s)
  T.Maeda, Y.Nagaoka, H.Kuwajima, C.Seno, S.Maruyama, M.Kurotani, S.Uesato
- Journal Title
  
  Bioorganic and Medicinal Chemistry 12
  
  Pages: 4351-4360
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590031
[Journal Article] Anti-Staphylococcus aureus activity and oxacillin resistance modulating capacity of 3-O-acyl-catechins.2004
- Author(s)
  P.D.Stapleton, S.Shah, J.M.T.H.-Miller, Y.Hara, Y.Nagaoka, A.Kumagai, S.Uesato, P.W.Taylor
- Journal Title
  
  International Journal of Antimicrobial Agents 22
  
  Pages: 1709-1716
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590031
[Journal Article] Inhibitory Effects of 3-O-acyl-(+)-catechins on Epstein-Barr Virus Activation.2003
- Author(s)
  S.Uesato, K.Taniuchi, A.Kumagai, Y.Nagaoka, R.Seto, Y.Hara
- Journal Title
  
  Chemical and Pharmaceutical Bulletin 51(12)
  
  Pages: 1448-1450
- NAID
  110003615244
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590031
[Journal Article] Peptaibolとその誘導体のイオンチャンネル特性2003
- Author(s)
  長岡康夫
- Journal Title
  
  膜(MEMBRANE). 28・2
  
  Pages: 61-69
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590031
[Journal Article] Antiproliferative Activity of Some Catechins against Her2/neu-Overexpressing Human Breast Carcinoma SKBR3.2003
- Author(s)
  T.Maeda, Y.Nagaoka, S.Kobayashi, Y.Hara, H.Tokuda, H.Nishino, S.Uesato
- Journal Title
  
  Natural Medicines 57(1)
  
  Pages: 31-33
- NAID
  110008732232
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590031
[Journal Article] Ion channels of alamethicin dimer N-terminally linked by disulfide bond.2003
- Author(s)
  T.Okazaki, M.Sakoh, Y.Nagaoka, K.Asami
- Journal Title
  
  Biophysical Journal 85
  
  Pages: 267-273
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590031
[Journal Article] Asymmetric Michael-aldol tandem cyclization of ω-oxo-α,β-unsaturated esters with 10-mercaptoisoborneol methyl ether.2003
- Author(s)
  K.Nishimura, H.Tsubouchi, M.Ono, T.Hayama, Y.Nagaoka, K.Tomioka
- Journal Title
  
  Tetrahedron Letters 44
  
  Pages: 2323-2326
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590031
[Journal Article] N-terminal insertion of alamethicin in channel formation studied using its covalent dimer N-terminally linked by disulfide bond.2003
- Author(s)
  M.Sakoh, T.Okazaki, Y.Nagaoka, K.Asami
- Journal Title
  
  Biochimica.Biophysica.Acta 1612
  
  Pages: 117-121
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590031
[Journal Article] Ion channel properties of Peptaibol and its derivatives.2003
- Author(s)
  Y.Nagaoka
- Journal Title
  
  MEMBRANE 28(2)
  
  Pages: 61-69
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590031
[Patent] 遺伝子発現増強剤2012
- Inventor(s)
  長岡康夫、上里新一
- Industrial Property Rights Holder
  学校法人関西大学
- Industrial Property Number
  2012-052395
- Filing Date
  2012-03-09
- Data Source
  KAKENHI-PROJECT-21590131
[Patent] 遺伝子導入剤2012
- Inventor(s)
  長岡康夫, 上里新一
- Industrial Property Rights Holder
  関西大学
- Industrial Property Number
  2012-052395
- Filing Date
  2012-03-09
- Data Source
  KAKENHI-PROJECT-21590131
[Patent] メイラード反応阻害剤2012
- Inventor(s)
  長岡康夫、河原秀久、山本秀樹、芝田隼次、小幡斉、上里新一
- Industrial Property Rights Holder
  学校法人関西大学
- Acquisition Date
  2012-01-06
- Data Source
  KAKENHI-PROJECT-21590131
[Patent] チロシナーゼ誘導抑制剤及びメラニン合成抑制剤2012
- Inventor(s)
  竹森洋, 熊谷彩子, 森田純子, 渕野裕之, 川原信夫, 飯田修, 杉村康司, 志賀幸生, 鎌田文広, 香月茂樹, 河原秀久, 長岡康夫
- Industrial Property Rights Holder
  株式会社桃谷順天館
- Industrial Property Rights Type
  特許
- Filing Date
  2012-11-24
- Data Source
  KAKENHI-PROJECT-23390082
[Patent] PPARd 活性化剤および PPARd 活性化剤の製造方法2011
- Inventor(s)
  河原秀久, 長岡康夫, 竹森洋, 小出芳栄
- Industrial Property Rights Holder
  学校法人関西大学,独立行政法人医薬基盤研究所,有限会社一栄
- Industrial Property Rights Type
  特許
- Filing Date
  2011-11-16
- Data Source
  KAKENHI-PROJECT-23390082
[Patent] PPARd活性化剤およびPPARd活性化剤の製造方法2011
- Inventor(s)
  河原秀久、長岡康夫、竹森洋、小出芳栄
- Industrial Property Rights Holder
  学校法人関西大学、独立行政法人医薬基盤研究所、有限会社一栄
- Industrial Property Number
  2011-250865
- Filing Date
  2011-11-26
- Data Source
  KAKENHI-PROJECT-23390082
[Patent] 遺伝子発現増強剤およびそれを用いた遺伝子発現増強方法2008
- Inventor(s)
  長岡康夫、服部喜之、上里新一、米谷芳江
- Industrial Property Rights Holder
  学校法人関西大学
- Industrial Property Number
  2008-189946
- Filing Date
  2008-07-23
- Data Source
  KAKENHI-PROJECT-19590110
[Patent] 特許2008
- Inventor(s)
  長岡康夫, 服部喜之, 上里新一, 米谷芳枝
- Industrial Property Rights Holder
  学校法人関西大学
- Industrial Property Number
  2008-189946
- Filing Date
  2008-08-23
- Data Source
  KAKENHI-PROJECT-19590110
[Patent] カルボキサミド誘導体2005
- Inventor(s)
  上里新一, 長岡康夫, 前田泰司
- Industrial Property Rights Holder
  学校法人関西大学
- Industrial Property Number
  2005-181043
- Filing Date
  2005-06-21
- Data Source
  KAKENHI-PROJECT-15310154
[Patent] 有機化合物の製造方法およびそれに用いる抗体2005
- Inventor(s)
  上里新一, 長岡康夫, 河野武幸
- Industrial Property Rights Holder
  大阪TLO
- Filing Date
  2005-02-09
- Data Source
  KAKENHI-PROJECT-14655343
[Presentation] Effect of histone deacetylase inhibitors on transfection of IFN-beta anti-cancer therapeutic gene into human breast cancer cells2017
- Author(s)
  R. Sueyoshi, R. Nishimura, T. Sumiyoshi, Y. Nagaoka
- Organizer
  The 12th International Symposium in Science and Technology 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08035
[Presentation] Identification of aldehydes as lipid peroxidation end-product in hair and scalp formed under the hair bleaching or UV irradiation conditions2017
- Author(s)
  D. Fukuzaki, Y. Kokuwano, S. Kitayama, T. Sumiyoshi, Y. Nagaoka
- Organizer
  The 12th International Symposium in Science and Technology 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08035
[Presentation] Design and synthesis of PEGylated peptide micellar formulation for cancer gene therapy2017
- Author(s)
  T. Inada, M. Katsuragi, G. Kimura, T. Sumiyoshi, Y. Nagaoka
- Organizer
  The 12th International Symposium in Science and Technology 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08035
[Presentation] Histone Deacetylase Inhibitors as Lipofection Enhancer2016
- Author(s)
  S. Mashi, T. Sumiyoshi, Y. Nagaoka
- Organizer
  The 11th International Symposium in Science and Technology 2016
- Place of Presentation
  関西大学（大阪府）
- Year and Date
  2016-07-26
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08035
[Presentation] Design and Synthesis of PEGylated Hydroxamic Acid-Type Histone Deacetylase Inhibitor Prodrugs Having Targeting Ability to Cancer Tissue2016
- Author(s)
  G. Kimura, H. Aihara, H. Kamijo, M. Katsuragi, T. Inada,　S. Uesato, T. Sumiyoshi, Y. Nagaoka
- Organizer
  Design and Synthesis of PEGylated Hydroxamic Acid-Type Histone Deacetylase Inhibitor Prodrugs Having Targeting Ability to Cancer Tissue, The 11th International Symposium in Science and Technology 2016
- Place of Presentation
  関西大学（大阪府）
- Year and Date
  2016-07-26
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08035
[Presentation] Enhanced Effect of Histone Deacetylase Inhibitors on Expression of Therapeutic shRNA Gene Targeting Proto-Oncogenic Factor, Cdc62016
- Author(s)
  M. Noor, H. Aihara, R. Nishimura, M. Katsuragi, Y. Nagaoka
- Organizer
  The 11th International Symposium in Science and Technology 2016
- Place of Presentation
  関西大学（大阪府）
- Year and Date
  2016-07-26
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08035
[Presentation] Epigenetic Control of Therapeutic Gene Expression in Breast Cancer Cells with Histone Deacetylase Inhibitors2016
- Author(s)
  R. Nishimura, H. Aihara, M. Katsuragi, Y. Fukushima, S. Uesato, T. Sumiyoshi, Y. Nagaoka
- Organizer
  The 11th International Symposium in Science and Technology 2016
- Place of Presentation
  関西大学（大阪府）
- Year and Date
  2016-07-26
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08035
[Presentation] IFN-β発現遺伝子を用いたがん遺伝子治療に対するヒストン脱アセチル化酵素阻害剤の併用効果2016
- Author(s)
  相原浩人、西村伶、木村元気、住吉孝明、長岡康夫
- Organizer
  日本薬学会第136年会
- Place of Presentation
  横浜
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-15K08035
[Presentation] ヒストン脱アセチル化酵素阻害剤の遺伝子増強作用を利用したがん遺伝子治療の効率化2016
- Author(s)
  西村伶、末吉燎平、上里新一、住吉孝明、長岡康夫
- Organizer
  第66回日本薬学会近畿支部総会・大会
- Place of Presentation
  大阪薬科大学（大阪府）
- Data Source
  KAKENHI-PROJECT-15K08035
[Presentation] Design and Synthesis of PEGylated Hydroxamic Acid-Type Histone Deacetylase Inhibitor Prodrugs Having Targeting Ability to Cancer Tissues2015
- Author(s)
  Genki Kimura, Hiroto Aihara, Hiroto Kamijo, Mizuki Katsuragi, Yuya Fukushima, Shinichi Uesato, Takaaki Sumiyoshi, Yasuo Nagaoka
- Organizer
  The 2015 International Chemical Congress of Pacific Basin Societies
- Place of Presentation
  米国（ホノルル）
- Year and Date
  2015-12-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08035
[Presentation] Neuroprotective Effect of Biflavones Isolated from Leaves of Sciadopitys verticillata2015
- Author(s)
  Yasuaki Tanaka, Yoshihisa Hirata, Daiki Iibata, Shintaro Kitayama, Mako Tamano, Yukihiro Yoshimoto, Naofumi Fukata, Takaaki Sumiyoshi, Yasuo Nagaoka,
- Organizer
  The 2015 International Chemical Congress of Pacific Basin Societies
- Place of Presentation
  米国（ホノルル）
- Year and Date
  2015-12-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08035
[Presentation] Combination of Histone Deacetylase Inhibitors and Lipofection-Mediated INF-β Gene Therapy2015
- Author(s)
  Rei Nishimura, Hiroto Aihara, Mizuki Katsuragi, Yuya Fukushima, Shinichi Uesato, Takaaki Sumiyoshi, Yasuo Nagaoka
- Organizer
  The 2015 International Chemical Congress of Pacific Basin Societies
- Place of Presentation
  米国（ホノルル）
- Year and Date
  2015-12-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08035
[Presentation] ANTITUMOR EFFECT OF PEGYLATED HISTONE DEACETYLASE INHIBITOR2013
- Author(s)
  Hiroto Kamijo, Mariko Kobayashi, Mako Tamano, Yukihiro Yoshimoto, Shinichi Uesato, and Yasuo Nagaoka
- Organizer
  49th International Conference on Medicinal Chemistry
- Place of Presentation
  Nice, France
- Data Source
  KAKENHI-PROJECT-24590152
[Presentation] ヒストン脱アセチル化酵素阻害剤とその誘導体のリポフェクションに及ぼす影響2012
- Author(s)
  長岡康夫, 吉野宏美, 小林真理子, 置田裕子, 中野宏樹, 上里新一
- Organizer
  日本薬学会第132年会
- Place of Presentation
  北海道大学
- Data Source
  KAKENHI-PROJECT-21590131
[Presentation] ENHANCED EFFECT OF HISTONE DEACETYLASE INHIBITORS ON THE EXPRESSION OF LIPOFECTED GENES2012
- Author(s)
  M. Kobayashi, H. Yoshino, H. Kamijo, K. Mizushima, S. Matsue, S. Uesato, Y. Nagaoka
- Organizer
  48th International Conference on Medicinal Chemistry (RICT 2012)
- Place of Presentation
  Poitiers, France
- Data Source
  KAKENHI-PROJECT-24590152
[Presentation] 塩誘導性キナーゼ 2 (SIK2)の新規メラニン合成調節機構について2012
- Author(s)
  熊谷彩子,堀家なな緒,伊東祐美,長岡康夫,竹森洋
- Organizer
  第85回日本生化学会
- Place of Presentation
  福岡
- Year and Date
  2012-12-16
- Data Source
  KAKENHI-PROJECT-23390082
[Presentation] リポフェクション効率向上効果を有するプロドラッグ化ヒストン脱アセチル化酵素阻害剤2011
- Author(s)
  置田裕子、中野宏樹、吉田耕平、吉野宏美、上里新一、服部喜之、米谷芳枝、長岡康夫
- Organizer
  日本薬学会131年会
- Place of Presentation
  グランシップツインメッセ静岡
- Data Source
  KAKENHI-PROJECT-21590131
[Presentation] Histone Deacetylase Inhibitors as Lipofection Enhancer2011
- Author(s)
  H. Yoshino, M. Kobayashi, H. Okita, H. Nakano, S. Uesato, Y. Nagaoka
- Organizer
  8th AFMC International Medicinal Chemistry Symposium
- Place of Presentation
  京王プラザホテル
- Data Source
  KAKENHI-PROJECT-21590131
[Presentation] 類型の異なるヒストン脱アセチル化酵素阻害剤がリポフェクション効率におよぼす影響2011
- Author(s)
  吉野宏美、置田裕子、中野宏樹、服部喜之、米谷芳枝、上里新一、長岡康夫
- Organizer
  日本薬学会131年会
- Place of Presentation
  グランシップツインメッセ静岡
- Data Source
  KAKENHI-PROJECT-21590131
[Presentation] トキワムシゴケのアセトン抽出物によるメラニン生成抑制機構の解明2011
- Author(s)
  下野優子、竹森洋、長岡康夫、河原秀久、山原年
- Organizer
  第10回日本地衣学会
- Place of Presentation
  神戸薬科大学(兵庫)
- Year and Date
  2011-07-09
- Data Source
  KAKENHI-PROJECT-23390082
[Presentation] Histone Deacetylase Inhibitors as Lipofection Enhancer2011
- Author(s)
  H.Yoshino, M.Kobayashi, H.Okita, H.Nakano, S.Uesato, Y.Nagaoka
- Organizer
  8th AFMC International Medicinal Chemistry Symposium
- Place of Presentation
  京王プラザホテル(東京)
- Year and Date
  2011-11-29
- Data Source
  KAKENHI-PROJECT-21590131
[Presentation] Prodrugs of Histone Deacetylase Inhibitor K-182 Enhanced Expression of Genes Transfected with Cationic Cholesterol-Based Nanoparticle Vector2010
- Author(s)
  H. Okita, Y. Ishii, S. Uesato, Y. Hattori, Y. Maitani, Y. Nagaoka
- Organizer
  11th Tetrahedron Symposium
- Place of Presentation
  北京大学
- Data Source
  KAKENHI-PROJECT-21590131
[Presentation] Acyl Suberoylanilide Hydroxamic Acid as Lipofection Enhancer2010
- Author(s)
  H. Nakano, S. Uesato, Y. Nagaoka
- Organizer
  11th Tetrahedron Symposium
- Place of Presentation
  北京大学
- Data Source
  KAKENHI-PROJECT-21590131
[Presentation] 新規遺伝子発現増強剤DDTS-K-1822010
- Author(s)
  中野宏樹、置田裕子、石井佑太、長岡康夫、上里新一、服部喜之、米谷芳枝
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山大学
- Data Source
  KAKENHI-PROJECT-21590131
[Presentation] Prodrugs of Histone Deacetylase Inhibitor K-182 Enhanced Expression of Genes Transfected with Cationic Cholesterol-Based Nanoparticle Vector2010
- Author(s)
  H.Okita, Y.Ishii, S.Uesato, Y.Hattori, Y.Maitani, Y.Nagaoka
- Organizer
  11th Tetrahedron Symposium
- Place of Presentation
  北京大学(中国)
- Year and Date
  2010-06-22
- Data Source
  KAKENHI-PROJECT-21590131
[Presentation] 硫黄原子を有する新規ヒストン脱アセチル化酵素阻害剤の創生2009
- Author(s)
  清川真吾、長岡康夫、上里新一
- Organizer
  日本薬学会第129年会要旨集2 P.151
- Place of Presentation
  国立京都国際会館
- Data Source
  KAKENHI-PROJECT-19590110
[Presentation] 新規経口ヒストン脱アセチル化酵素阻害剤K-197の抗腫瘍効果について2009
- Author(s)
  上里新一、清川真吾、平田佳之、長岡康夫、芝野真喜雄、谷口雅彦、安田正秀、馬場きみ江
- Organizer
  日本薬学会第129年会要旨集2 P.151
- Place of Presentation
  国立京都国際会館
- Data Source
  KAKENHI-PROJECT-19590110
[Presentation] ニュートラルロスキャン法およびMS/MS法を用いたタキソールータンパク質複合体形成の確認について2009
- Author(s)
  白浜辰弥, 武本佳樹, 山本智加, 根岸淳, 長岡康夫, 上里新一
- Organizer
  日本薬学会129年会
- Place of Presentation
  京都国際会議場
- Year and Date
  2009-03-26
- Data Source
  KAKENHI-PROJECT-19550114
[Presentation] 非ウイルスベクターによる外部導入遺伝子の発現を増強するヒストン脱アセチル化酵素阻害剤プロドラッグの開発2009
- Author(s)
  石井佑太、山田敏晴、濱本和隆、田中菜津子、上里新一、長岡康夫、服部喜之、米谷芳枝
- Organizer
  日本薬学会第129年会要旨集4 P.215
- Place of Presentation
  国立京都国際会館
- Data Source
  KAKENHI-PROJECT-19590110
[Presentation] ニュートラルロススキャン法およびMS/MS法を用いたタキソール-タンパク質複合体形成の確認について2009
- Author(s)
  白浜辰弥, 武本佳樹, 山本智加, 根岸淳, 長岡康夫, 上里新一
- Organizer
  日本薬学会第129年会
- URL
  http://pharm.life-bio.kansai-u.ac.jp
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-19550114
[Presentation] モノクローナル抗体を反応場としたタキソール合成の試み-抗クキソールモノクローナル抗体の作製2009
- Author(s)
  武本佳樹, 白浜辰弥, 河野武幸, 辻琢己, 盛實祐希, 長岡康夫, 上里新一
- Organizer
  日本薬学会129年会
- Place of Presentation
  京都国際会議場
- Year and Date
  2009-03-27
- Data Source
  KAKENHI-PROJECT-19550114
[Presentation] モノクローナル抗体を反応場としたタキソール合成の試み-抗タキソールモノクローナル抗体の作製2009
- Author(s)
  武本佳樹, 白浜辰弥, 河野武幸, 辻琢己, 盛實祐希, 長岡康夫, 上里新一
- Organizer
  日本薬学会第129年会
- Place of Presentation
  京都
- Year and Date
  2009-03-27
- Data Source
  KAKENHI-PROJECT-19550114
[Presentation] 新規細胞周期M期制御化合物の抗がん活性と関連化合物の構造活性相関について2009
- Author(s)
  瓦谷泰之, 平田佳之, 長岡康夫, 原田知彦, 上里新一, 芝野真喜雄, 谷口雅彦, 安田正秀, 馬場きみ江
- Organizer
  第28回メディシナルケミストリーシンポジウム
- Place of Presentation
  東大本郷
- Year and Date
  2009-11-25
- Data Source
  KAKENHI-PROJECT-19550114
[Presentation] Novel M-phase regulating compounds comprising a nitrooxymethyl group in the molecule2009
- Author(s)
  Uesato S., Kawaratani Y., Nagaoka Y
- Organizer
  第68回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2009-10-03
- Data Source
  KAKENHI-PROJECT-19550114
[Presentation] 正電荷ナノ粒子ベクターによる外部導入遺伝子の発現を増強するヒストン脱アセチル化酵素阻害剤プロドラツグの開発2008
- Author(s)
  長岡康夫, 山田敏晴, 石井佑太, 濱本和隆, 田中菜津子, 上里新一, 服部喜之, 米谷芳枝
- Organizer
  第27回メディシナルケミストリーシンポジウム
- Place of Presentation
  大阪(メルパルク大阪)
- Year and Date
  2008-11-26
- Data Source
  KAKENHI-PROJECT-19590110
[Presentation] 経口性ヒストン脱アセチル化酵素阻害剤K-197の開発2008
- Author(s)
  清川真吾、前田泰司、平田佳之、長岡康夫、上里新一(大阪薬大)芝野真喜雄、谷口雅彦、安田正秀、馬場きみ江
- Organizer
  第27回メディシナルケミストリーシンポジウム要旨集p.142-143
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-19590110
[Presentation] 正電荷ナノ粒子ベクターによる外部導入遺伝子の発現を増強するヒストン脱アセチル化酵素阻害剤プロドラッグの開発2008
- Author(s)
  長岡康夫、山田敏晴、石井佑太、濱本和隆、田中菜津子、上里新一、服部喜之、米谷芳枝
- Organizer
  第27回メディシナルケミストリーシンポジウム要旨集p.330-332
- Place of Presentation
  メルパルク大阪
- Data Source
  KAKENHI-PROJECT-19590110
[Presentation] PEG化ヒストン脱アセチル化酵素阻害剤の抗がん活性
- Author(s)
  上條洋士、木村元気、服部善之、住吉孝明、上里新一、長岡康夫
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸学院大学他（神戸）
- Year and Date
  2015-03-25 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-24590152
[Presentation] Enhanced Effect of Histone Deacetylase Inhibitors on Expression of Therapeutic shRNA Gene Targeting Proto-Oncogenic Factor, CDC6
- Author(s)
  Hiroto Aihara, Mariko Kobayashi, Hiromi Yoshino, Yoshihisa Hirata, Shinichi Uesato, Takaaki Sumiyoshi, Yasuo Nagaoka
- Organizer
  50th International Conference on Medicinal Chemistry
- Place of Presentation
  フランス（ルーアン）
- Year and Date
  2014-07-02 – 2014-07-04
- Data Source
  KAKENHI-PROJECT-24590152

1. IIDA Akira (40202816)

# of Collaborated Projects: 8 results

# of Collaborated Products: 0 results
2. UESATO Shinichi (50111969)

# of Collaborated Projects: 7 results

# of Collaborated Products: 33 results
3. TOMIOKA Kiyoshi (50114575)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
4. UEDA Shinichi (20025688)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
5. KOUNO Takeyuki (50178224)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
6. HATTORI Yoshiyuki (90350222)

# of Collaborated Projects: 3 results

# of Collaborated Products: 13 results
7. 藤多哲朗 (40027024)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
8. YAMADA Ken-ichi (00335184)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. TAKEMORI Hiroshi (90273672)

# of Collaborated Projects: 2 results

# of Collaborated Products: 9 results
10. KITAGAWA Kazuo (70301257)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
11. sasaki tsutomu (20534879)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
12. IWAKI Hiroaki (00368200)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
13. 市原潤子 (60110772)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
14. 金井求 (20243264)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
15. HATANO Osamu (40164850)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
16. KUMAGAI Ayako (20455869)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
17. mochiduki hideki (90230044)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. TOKUDA Harukuni (60111960)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 浅見耕司 (90127936)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 田端俊英 (80303270)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
21. 平田佳之 (00745854)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. INOUE Isao

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. ADACHI Shigeki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. NOMURA Taisei

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
25. YOKOYAMA Tomoki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
26. FUKUSHIMA Toshiki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
27. 渡辺秀人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
28. 谷村進

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
29. 梁治子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
30. 水口賢司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

NAGAOKA Yasuo 長岡 康夫

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Development of formulation for gene therapy utilizing epigenetic effect of HDAC inhibitorsPrincipal Investigator

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Development of PEGylated Histone Deacetylase Inhibitor Having Prolonged Blood Retention and EPR effectPrincipal Investigator

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Development of cationic histone deacetylase inhibitors as enhancer of gene transfection and expressionPrincipal Investigator

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Synthesis of Histone Deacetylase Inhibitors Toward the Development of DDSPrincipal Investigator

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Development of asymmetric syntheses and valuable bioactive compounds based on alkenylphosphonatesPrincipal Investigator

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Development of reactions based on addition of electrophiles to methylenebisphosphonatesPrincipal Investigator

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チオールの触媒的不斉共役付加反応を契機とする連続不斉点構築法の開拓Principal Investigator

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NAGAOKA Yasuo 長岡康夫