Ogo Naohisa 小郷尚久

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OGO Naohisa 小郷尚久

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Researcher Number	20501307
Other IDs
Affiliation (Current)	2025: 静岡県立大学, 薬学研究院, 講師
Affiliation (based on the past Project Information) *help	2016 – 2025: 静岡県立大学, 薬学研究院, 講師 2014 – 2015: 静岡県立大学, 薬学研究科(研究院), 講師 2014: 静岡県立大学, 薬学研究院・創薬探索センター, 講師 2013: 静岡県立大学, 薬学研究院, 講師 2012 – 2013: 静岡県環境衛生科学研究所, その他部局等, その他
Review Section/Research Field	Principal Investigator Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related / Drug development chemistry Except Principal Investigator Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related / Sections That Are Subject to Joint Review: Basic Section47010:Pharmaceutical chemistry and drug development sciences-related , Basic Section47050:Environmental and natural pharmaceutical resources-related / Basic Section 47050:Environmental and natural pharmaceutical resources-related / Plant nutrition/Soil science / Clinical oncology / Biological Sciences
Keywords	Principal Investigator プロドラッグ / KSP / システイン誘導体 / 構造活性相関 / 抗がん / 細胞増殖阻害 / 構造最適化 / ライブラリー / ADC / non-cleavableリンカー … More / cleavableリンカー / 酵素切断リンカー / リンカーペイロード / Trastuzumab / in silico / 抗体薬物複合体 / SMDC / がん微小環境 / デュアル作用 / 次世代抗がん剤 / GGT / がん細胞選択的 / MD解析 / デュアル作用薬 / HCT116 / 代謝安定性 / 溶解度 / 抗腫瘍効果 / 抗がん剤 … More Except Principal Investigator がん免疫療法 / ドラッグデザイン / 免疫チェックポイント / キメラ化合物 / 併用効果 / PD-L1 / ハイブリッド化合物 / ドッキングシミュレーション / スクリーニング / がん免疫 / 腫瘍微小環境 / TDO / IDO / キヌレニン / トリプトファン / 抗がん剤 / 酸ストレス / アルミニウムストレス / ケミカルバイオロジー / 植物栄養学 / シグナル伝達経路 / 化合物ライブラリー / リンゴ酸分泌 / AtALMT1 / 酸性土壌 / ホモロジーモデリング / シグナル伝達 / アルミニウム / kinase阻害化合物ライブラリー / in silicoドッキング / STOP1 / ALMT1 / 酸性土壌耐性 / ケミカルスクリーニング / アルミニウムシグナル / 国際情報交換 / がん幹細胞治療薬 / 生体分子 / 血小板凝集 / がん転移 / 細胞死 / 微小環境 / 血小板 / Merm1 / 転移 / がん微小環境 / 癌 Less

新規経口がん免疫治療薬の開発に向けたIDO1/TDO阻害剤の多面的構造最適化研究Principal Investigator
- Principal Investigator
  
  小郷尚久
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
- Research Institution
  University of Shizuoka
独自のがん免疫療法シーズに基づく二重機能性キメラ化合物の開発
- Principal Investigator
  
  浅井章良
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
  Basic Section 47050:Environmental and natural pharmaceutical resources-related
  Sections That Are Subject to Joint Review: Basic Section47010:Pharmaceutical chemistry and drug development sciences-related , Basic Section47050:Environmental and natural pharmaceutical resources-related
- Research Institution
  University of Shizuoka
Basic drug discovery research aimed at developing new combination cancer immunotherapies
- Principal Investigator
  
  Asai Akira
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
- Research Institution
  University of Shizuoka
Development of novel antibody-drug conjugates utilizing the KSP inhibition of cysteine derivativesPrincipal Investigator
- Principal Investigator
  
  Ogo Naohisa
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
- Research Institution
  University of Shizuoka
Basic research for development of IDO/TDO dual inhibitors as new immuno-oncology drugs
- Principal Investigator
  
  Asai Akira
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
- Research Institution
  University of Shizuoka
Development of novel KSP inhibitors highly selective for cancer cellsPrincipal Investigator
- Principal Investigator
  
  Ogo Naohisa
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  University of Shizuoka
Characterization of low pH and aluminum signal transduction based on chemical genetics
- Principal Investigator
  
  KOBAYASHI Yuriko
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Plant nutrition/Soil science
- Research Institution
  Gifu University
Novel cysteine derivatives for the next generation anticancer agents acting on KSPPrincipal Investigator
- Principal Investigator
  
  Ogo Naohisa
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  University of Shizuoka
Development of a novel small-molecule compounds targeting cancer stem cells derived from malignant glioma
- Principal Investigator
  
  ASHIZAWA Tadashi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Clinical oncology
- Research Institution
  Shizuoka Cancer Center Research Institute
Molecular analysis of metastasis-related tumor microenvironment and development of new anti-metastatic therapy
- Principal Investigator
  
  FUJITA Naoya
- Project Period (FY)
  2010 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Japanese Foundation for Cancer Research

All 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2012 2011 Other

All Journal Article Presentation Patent

[Journal Article] Combined therapeutic effect of YHO-1701 with PD-1 blockade is dependent on natural killer cell activity in syngeneic mouse models2023
- Author(s)
  Takahashi Hiroyuki、Miyoshi Nao、Murakami Hisashi、Okamura Yuta、Ogo Naohisa、Takagi Akimitsu、Muraoka Daisuke、Asai Akira
- Journal Title
  
  Cancer Immunology, Immunotherapy
  
  Volume: 72 Issue: 7 Pages: 2473-2482
- DOI
  10.1007/s00262-023-03440-4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H02609
[Journal Article] Identification of serum and glucocorticoid-regulated kinase 1 as a regulator of signal transducer and activator of transcription 3 signaling2022
- Author(s)
  Araki Toshihiro、Watanabe Yuuki、Okada Yusuke、Murakami Hisashi、Ogo Naohisa、Asai Akira
- Journal Title
  
  Experimental Cell Research
  
  Volume: 413 Issue: 2 Pages: 113079-113079
- DOI
  10.1016/j.yexcr.2022.113079
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H02609
[Journal Article] STAT3 inhibition suppresses adaptive survival of ALK-rearranged lung cancer cells through transcriptional modulation of apoptosis.2022
- Author(s)
  Yanagimura N, Takeuchi S, Fukuda K, Arai S, Tanimoto A, Nishiyama A, Ogo N, Takahashi H, Asai A, Watanabe S, Kikuchi T, Yano S.
- Journal Title
  
  NPJ Precis Oncol
  
  Volume: 6 Issue: 1 Pages: 11-11
- DOI
  10.1038/s41698-022-00254-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18KT0019, KAKENHI-PROJECT-19H03665, KAKENHI-PROJECT-21H02609, KAKENHI-PROJECT-20K08516, KAKENHI-PROJECT-23K20323
[Journal Article] Identification and Characterization of a Novel Dual Inhibitor of Indoleamine 2,3-dioxygenase 1 and Tryptophan 2,3-dioxygenase2022
- Author(s)
  Yoshioka Saeko、Ikeda Tomonori、Fukuchi Sogo、Kawai Yurika、Ohta Katsumi、Murakami Hisashi、Ogo Naohisa、Muraoka Daisuke、Takikawa Osamu、Asai Akira
- Journal Title
  
  International Journal of Tryptophan Research
  
  Volume: 15
- DOI
  10.1177/11786469221138456
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H02609
[Journal Article] Chemical augmentation of mitochondrial electron transport chains tunes T cell activation threshold in tumors2022
- Author(s)
  Dotsu Yosuke、Muraoka Daisuke、Ogo Naohisa、Sonoda Yudai、Yasui Kiyoshi、Yamaguchi Hiroyuki、Yagita Hideo、Mukae Hiroshi、Asai Akira、Ikeda Hiroaki
- Journal Title
  
  Journal for ImmunoTherapy of Cancer
  
  Volume: 10 Issue: 2 Pages: e003958-e003958
- DOI
  10.1136/jitc-2021-003958
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09048, KAKENHI-PROJECT-21H02609, KAKENHI-PROJECT-22K08876, KAKENHI-PROJECT-21H02990
[Journal Article] Design, synthesis, and evaluation of a novel prodrug, a S-trityl--cysteine derivative targeting kinesin spindle protein2021
- Author(s)
  Fukai Ryota、Ogo Naohisa、Ichida Taiki、Yamane Masayoshi、Sawada Jun-ichi、Miyoshi Nao、Murakami Hisashi、Asai Akira
- Journal Title
  
  European Journal of Medicinal Chemistry
  
  Volume: 215 Pages: 113288-113288
- DOI
  10.1016/j.ejmech.2021.113288
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H02609, KAKENHI-PROJECT-20K06969
[Journal Article] Various effects of two types of kinesin-5 inhibitors on mitosis and cell proliferation2021
- Author(s)
  Sawada Jun-ichi、Matsuno Kenji、Ogo Naohisa、Asai Akira
- Journal Title
  
  Biochemical Pharmacology
  
  Volume: 193 Pages: 114789-114789
- DOI
  10.1016/j.bcp.2021.114789
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H02609, KAKENHI-PROJECT-20K06969
[Journal Article] Antitumor activity of a novel oral STAT3 inhibitor YHO-17012020
- Author(s)
  Fukiko Nishisaka, Keisuke Taniguchi, Momomi Tsugane, Genya Hirata, Akimitsu Takagi, Naoyuki Asakawa, Akinobu Kurita, Hiroyuki Takahashi, Naohisa Ogo, Yoshiyuki Shishido, Akira Asai
- Journal Title
  
  Cancer Sci.
  
  Volume: 111 Issue: 5 Pages: 1774-1784
- DOI
  10.1111/cas.14369
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02559
[Journal Article] STX‐0119, a novel STAT3 dimerization inhibitor, prevents fibrotic gene expression in a mouse model of kidney fibrosis by regulating Cxcr4 and Ccr1 expression2020
- Author(s)
  Makitani Kouki、Ogo Naohisa、Asai Akira
- Journal Title
  
  Physiological Reports
  
  Volume: 8 Issue: 20
- DOI
  10.14814/phy2.14627
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02559
[Journal Article] Discovery of a New STAT3 Inhibitor Acting on the Linker Domain2019
- Author(s)
  Tatsuya Koseki, Naoya Suehiro, Yoshiaki Masuda, Nao Miyoshi, Daisuke Muraoka, Naohisa Ogo, Akira Asai
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 42 Issue: 5 Pages: 792-800
- DOI
  10.1248/bpb.b18-00992
- NAID
  130007641492
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2019-05-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02559
[Journal Article] Identification of benzo[d]pyrrolo[2,1-b]thiazole derivatives as CENP-E inhibitors.2019
- Author(s)
  Yamane M, Sawada JI, Ogo N, Ohba M, Ando T, Asai A.Yamane M
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 519 Issue: 3 Pages: 505-511
- DOI
  10.1016/j.bbrc.2019.09.028
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07315, KAKENHI-PROJECT-18H02559
[Journal Article] Modeling of aluminum-induced malate secretion by pharmacological approach in Arabidopsis: involvement of lipid signaling2019
- Author(s)
  Wu Liujie、Sadhukhan Ayan、Kobayashi Yuriko、Ogo Naohisa、Tokizawa Mutsutomo、Agrahari Raj Kishan、Ito Hiroki、Iuchi Satoshi、Kobayashi Masatomo、Asai Akira、Koyama Hiroyuki
- Journal Title
  
  Journal of Experimental Botany
  
  Volume: - Issue: 12 Pages: 3329-3342
- DOI
  10.1093/jxb/erz179
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H02559
[Journal Article] Structural and Thermodynamic Basis of the Enhanced Interaction between Kinesin Spindle Protein Eg5 and STLC-type Inhibitors2018
- Author(s)
  Yokoyama Hideshi、Sawada Jun-ichi、Sato Kohei、Ogo Naohisa、Kamei Nanami、Ishikawa Yoshinobu、Hara Kodai、Asai Akira、Hashimoto Hiroshi
- Journal Title
  
  ACS Omega
  
  Volume: 3 Issue: 9 Pages: 12284-12294
- DOI
  10.1021/acsomega.8b00778
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07314, KAKENHI-PROJECT-17K07316, KAKENHI-PROJECT-17K08366, KAKENHI-PROJECT-18K07315, KAKENHI-PUBLICLY-17H06014, KAKENHI-PROJECT-16H04755, KAKENHI-PROJECT-16H05113, KAKENHI-PROJECT-16H05840, KAKENHI-PROJECT-16K08199
[Journal Article] 共有結合フラグメントライブラリーを用いた生体内標的タンパク質の網羅的な探索2017
- Author(s)
  小郷尚久
- Journal Title
  
  Chemical Biology
  
  Volume: 10 Pages: 15-15
- Data Source
  KAKENHI-PROJECT-17K08366
[Journal Article] 共有結合フラグメントライブラリーを用いた生体内標的タンパク質の網羅的な探索2017
- Author(s)
  小郷尚久
- Journal Title
  
  Chemical Biology
  
  Volume: 10 Pages: 15-15
- Data Source
  KAKENHI-PROJECT-16K14870
[Journal Article] Structural Basis of New Allosteric Inhibition in Kinesin Spindle Protein Eg52015
- Author(s)
  Yokoyama H, Sawada J, Katoh S, Matsuno K, Ogo N, Ishikawa Y, Hashimoto H, Fujii S, Asai A.
- Journal Title
  
  ACS Chem. Biol.
  
  Volume: 10 Issue: 4 Pages: 1128-1136
- DOI
  10.1021/cb500939x
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24590141, KAKENHI-PUBLICLY-25121728, KAKENHI-PROJECT-25291017, KAKENHI-PROJECT-26440034, KAKENHI-PROJECT-26460150
[Journal Article] Structure-Guided Design of Novel L-Cysteine Derivatives as Potent KSP Inhibitors2015
- Author(s)
  Naohisa Ogo, Yoshinobu Ishikawa, Jun-ichi Sawada, Kenji Matsuno, Akihiro Hashimoto, and Akira Asai
- Journal Title
  
  ACS Med. Chem. Lett.
  
  Volume: 6 Issue: 9 Pages: 1004-1009
- DOI
  10.1021/acsmedchemlett.5b00221
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460150
[Journal Article] 新規KSP阻害剤の創製　‐システイン誘導体の合成と構造活性相関‐2015
- Author(s)
  小郷尚久、浅井章良
- Journal Title
  
  MEDCHEM NEWS
  
  Volume: 25 Pages: 88-94
- Data Source
  KAKENHI-PROJECT-26460150
[Journal Article] Identification of novel kynurenine production-inhibiting benzenesulfonamide derivatives in cancer cells2012
- Author(s)
  Nakano S, Takai K, Isaka Y, Takahashi S, Unno Y, Ogo N, Matsuno K, Takikawa O, Asai A.
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 419 Issue: 3 Pages: 556-561
- DOI
  10.1016/j.bbrc.2012.02.059
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590353, KAKENHI-PROJECT-24501362
[Journal Article] Transforming growth factor-β decreases the cancer-initiating cell population within diffuse-type gastric carcinoma cells.2011
- Author(s)
  Shogo Ehata
- Journal Title
  
  Oncogene
  
  Volume: 30 Pages: 1693-1705
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22112008
[Patent] ガン免疫療法においてIDO1阻害剤と併用する薬剤を選択する方法、及びIDO1阻害剤と併用する薬剤とを含むガン免疫療法用組成物2023
- Inventor(s)
  浅井章良、小郷尚久、村上央、三好奈央、中川貴之、加藤大貴
- Industrial Property Rights Holder
  静岡県公立大学法人
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2023-219833
- Filing Date
  2023
- Data Source
  KAKENHI-PROJECT-21H02609
[Patent] リンパ球機能亢進剤、リンパ球介在型がん治療法の治療剤との併用剤、及びリンパ球のミトコンドリア機能亢進剤2021
- Inventor(s)
  浅井章良、小郷尚久、池田裕明、村岡大輔、道津洋介
- Industrial Property Rights Holder
  浅井章良、小郷尚久、池田裕明、村岡大輔、道津洋介
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2021-203972
- Filing Date
  2021
- Data Source
  KAKENHI-PROJECT-21H02609
[Patent] IDO/TDO阻害剤2018
- Inventor(s)
  浅井章良、小郷尚久、村岡大輔、滝川修、河邊拓己、佐藤卓治
- Industrial Property Rights Holder
  浅井章良、小郷尚久、村岡大輔、滝川修、河邊拓己、佐藤卓治
- Industrial Property Rights Type
  特許
- Filing Date
  2018
- Overseas
- Data Source
  KAKENHI-PROJECT-18H02559
[Presentation] 免疫チェックポイント分子を標的とした低分子化合物の探索2024
- Author(s)
  林弘信、永岡菜、楳野幸人、車田千春、渡邉未来、市田泰輝、村上央、小郷尚久、浅井章良
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-21H02609
[Presentation] 腫瘍不均一性の克服へ向けた新規化合物のスクリーニング2023
- Author(s)
  安井潔、江原大輔、岡本幸子、峰野純一、村岡大輔、小郷尚久、浅井章良、室田浩之、池田裕明
- Organizer
  第82回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21H02609
[Presentation] BTLA-HVEM 結合阻害化合物スクリーニング系の構築2023
- Author(s)
  楳野幸人、村上央、小郷尚久、浅井章良
- Organizer
  第69回日本薬学会東海支部大会
- Data Source
  KAKENHI-PROJECT-21H02609
[Presentation] 腫瘍微小環境におけるトリプトファン代謝酵素が引き起こす免疫抑制機構の解析2023
- Author(s)
  村上央、小郷尚久、村岡大輔、浅井章良
- Organizer
  第82回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21H02609
[Presentation] 新規 IDO1/TDO 二重阻害剤の創製－イソチオウレア誘導体の合成と構造活性相関－2023
- Author(s)
  小郷尚久、田島和明、河合佑里香、太田克美、三好奈央、村上央、滝川修、佐藤卓治、河邊拓己、浅井章良
- Organizer
  第40回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-21H02609
[Presentation] キヌレニン経路の亢進による腫瘍微小環境の免疫学的変化と阻害薬による効果2023
- Author(s)
  河合佑里香、村上央、太田克美、三好奈央、小郷尚久、浅井章良
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-21H02609
[Presentation] キヌレニン経路の亢進による腫瘍微小環境の免疫学的変化2023
- Author(s)
  河合佑里香、加藤壮一郎、三好奈央、村上央、小郷尚久、浅井章良
- Organizer
  第69回日本薬学会東海支部大会
- Data Source
  KAKENHI-PROJECT-21H02609
[Presentation] 抗体薬物複合体を指向したS-trityl-L-cysteine誘導体を有する薬物リンカーの構造最適化2023
- Author(s)
  市田泰輝、深井椋太、村瀬啓輔、三好奈央、村上央、小郷尚久、浅井章良
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-20K06969
[Presentation] 新規 IDO1/TDO 二重阻害化合物の発見と構造活性相関研究2023
- Author(s)
  小郷尚久、田島和明、河合佑里香、太田克美、村上央、滝川修、浅井章良
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-21H02609
[Presentation] S -trityl-L-cysteine 誘導体と酵素切断リンカーコンジュゲートの合成と評価2023
- Author(s)
  村瀬啓輔、市田泰輝、小郷尚久、村上央、浅井章良
- Organizer
  第69回日本薬学会東海支部大会
- Data Source
  KAKENHI-PROJECT-21H02609
[Presentation] 腫瘍不均一性の克服へ向けた新規化合物のスクリーニング2023
- Author(s)
  安井潔、江原大輔、岡本幸子、峰野純一、村岡大輔、小郷尚久、浅井章良、室田浩之、池田裕明
- Organizer
  第27回日本がん免疫学会総会
- Data Source
  KAKENHI-PROJECT-21H02609
[Presentation] TIGIT-CD155結合阻害化合物スクリーニング系の構築2022
- Author(s)
  永岡菜、村上央、小郷尚久、浅井章良
- Organizer
  日本病院薬剤師会東海ブロック・日本薬学会東海支部合同学術大会2022
- Data Source
  KAKENHI-PROJECT-21H02609
[Presentation] S-trityl-L-cysteine誘導体を有する新規抗体薬物複合体の合成と薬物リンカーの構造最適化2022
- Author(s)
  市田泰輝、深井椋太、村瀬啓輔、三好奈央、村上央、小郷尚久、浅井章良
- Organizer
  第39回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-20K06969
[Presentation] マウス腫瘍微小環境におけるIDO1の抗腫瘍免疫抑制機能の解析2022
- Author(s)
  河合佑里香、村上央、太田克美、三好奈央、小郷尚久、浅井章良
- Organizer
  日本病院薬剤師会東海ブロック・日本薬学会東海支部合同学術大会2022
- Data Source
  KAKENHI-PROJECT-21H02609
[Presentation] ミトコンドリア電子伝達系を介してT細胞の活性化閾値を改善する新基軸代謝化合物を用いたがん免疫療法の開発2022
- Author(s)
  道津洋介、村岡大輔、園田祐大、小郷尚久、浅井章良、八木田秀雄、迎　寛、池田裕明
- Organizer
  第26回日本がん免疫学会総会
- Data Source
  KAKENHI-PROJECT-21H02609
[Presentation] がん免疫療法を指向した新規 IDO1/TDO 二重阻害化合物の探索2022
- Author(s)
  小郷尚久、田島和明、河合佑里香、吉岡紗衣子、太田克美、村上央、滝川修、浅井章良
- Organizer
  日本トリプトファン研究会第41回学術集会
- Data Source
  KAKENHI-PROJECT-21H02609
[Presentation] 新規IDO1/TDO二重阻害化合物の構造活性相関研究2022
- Author(s)
  田島和明、渡部美都、石原桃子、野中智陽、河合佑里香、吉岡紗衣子、太田克美、村上央、小郷尚久、浅井章良
- Organizer
  第39回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-21H02609
[Presentation] Novel STAT3 inhibitor, YHO-1701 enhances the antitumor effect of anti-PD-1 antibody2022
- Author(s)
  Hiroyuki Takahashi, Hisashi Murakami, Naohisa Ogo, Daisuke Muraoka, Akimitsu Takagi, Akira Asai
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21H02609
[Presentation] マウストリプトファン代謝酵素安定発現細胞株の作製と性状解析2021
- Author(s)
  河合佑里香、村上央、小郷尚久、村岡大輔、浅井章良
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-21H02609
[Presentation] The compound activating mitochondrial respiration leads PD-1 blockade efficacy even in a low immunogenic tumor2021
- Author(s)
  Yosuke Dotsu, Daisuke Muraoka, Yudai Sonoda, Naohisa Ogo, Akira Asai, Hideo Yagita, Hiroshi Mukae, Hiroaki Ikeda
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21H02609
[Presentation] STLC 誘導体を有する新規 ADC の設計と合成2021
- Author(s)
  市田泰輝、深井椋太、村上央、三好奈央、小郷尚久、浅井章良
- Organizer
  日本薬学会第141年会（広島）
- Data Source
  KAKENHI-PROJECT-20K06969
[Presentation] Discovery of novel cysteine derivatives to improve selectivity and targeting to cancer cells using in silico modeling2021
- Author(s)
  Naohisa Ogo, Hisashi Murakami, Akira Asai
- Organizer
  第79回日本癌学会学術総会（横浜）
- Data Source
  KAKENHI-PROJECT-20K06969
[Presentation] CTLA-4安定発現細胞の作製と抗体によるCTLA-4阻害作用の解析2021
- Author(s)
  村上央、渡邉未来、小郷尚久、浅井章良
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-21H02609
[Presentation] Discovery of novel cysteine derivatives to improve selectivity and targeting to cancer cells using in silico modeling2021
- Author(s)
  Naohisa Ogo, Hisashi Murakami, Akira Asai
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21H02609
[Presentation] 低分子化合物によるミトコンドリア機能の制御は、不十分な抗原刺激下における T 細胞をも活性化し、抗 PD-1 抗体療法の有効性を導く2021
- Author(s)
  道津洋介、村岡大輔、園田祐大、小郷尚久、浅井章良、八木田秀雄、迎寛、池田裕明
- Organizer
  第25回日本がん免疫学会総会
- Data Source
  KAKENHI-PROJECT-21H02609
[Presentation] STAT3 inhibition suppresses adaptive survival of ALK-rearanged cancer cells via transcriptional modulation of apoptosis2021
- Author(s)
  Naohiro Yanagimura, Shinji Takeuchi, Koji Fukuda, Akihiro Nishiyama, Naohisa Ogo, Akira Asai, Seiji Yano
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21H02609
[Presentation] がん免疫療法を指向した新規IDO1阻害化合物の設計と合成2020
- Author(s)
  小郷尚久、野仲智陽、石原桃子、渡部美都、太田克美、村上央、滝川修、浅井章良
- Organizer
  日本トリプトファン研究会第39回学術集会
- Data Source
  KAKENHI-PROJECT-18H02559
[Presentation] Discovery of novel isothiourea derivatives as potent dual inhibitors of IDO1 and TDO2020
- Author(s)
  Naohisa Ogo, Daisuke Muraoka, Takayuki Ando , Akira Asai
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18H02559
[Presentation] がん免疫療法を指向した新規IDO1阻害化合物の設計、合成と構造活性相関2020
- Author(s)
  小郷尚久、野中智陽、石原桃子、渡部美都、太田克美、村上央、滝川修、浅井章良
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-18H02559
[Presentation] M期キネシンKSP阻害剤と相乗的に細胞死を誘導する阻害剤の探索2020
- Author(s)
  澤田潤一、松野研司、小郷尚久、浅井彰良
- Organizer
  日本薬学会第140年会（京都）
- Data Source
  KAKENHI-PROJECT-17K08366
[Presentation] ADC を指向した STLC 誘導体を有する新規 linker-payload の設計と合成2020
- Author(s)
  市田泰輝、深井椋太、池田有明香、三好奈央、小郷尚久、浅井章良
- Organizer
  日本薬学会第140年会（京都）
- Data Source
  KAKENHI-PROJECT-17K08366
[Presentation] ADC を指向した STLC 誘導体を有する新規 linker-payload の設計と合成2020
- Author(s)
  市田泰輝、深井椋太、池田有明香、三好奈央、小郷尚久、浅井章良
- Organizer
  日本薬学会第140年会（京都）
- Data Source
  KAKENHI-PROJECT-20K06969
[Presentation] Low molecular weight compound enhancing NF-kB signaling augments the T cell activation and anti-tumor immune response2020
- Author(s)
  Daisuke Muraoka, Yosuke Dotsu, Yudai Sonoda, Naohisa Ogo, Akira Asai, Hiroaki Ikeda
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18H02559
[Presentation] がん免疫療法を指向したSBDDによる新規IDO1阻害化合物の探索2019
- Author(s)
  小郷尚久、野仲智陽、石原桃子、渡部美都、太田克美、村上央、滝川修、浅井章良
- Organizer
  第37回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-18H02559
[Presentation] がん細胞選択性向上を指向したS-trityl-L-cysteine (STLC)誘導体のプロドラッグデザイン2019
- Author(s)
  深井椋太、小郷尚久、市田泰輝、山根正敬、三好奈央、浅井章良
- Organizer
  第37回メディシナルケミストリーシンポジウム（八王子）
- Data Source
  KAKENHI-PROJECT-17K08366
[Presentation] SBDDによる新規IDO1阻害化合物の合成と構造活性相関研究2019
- Author(s)
  野仲智陽、小郷尚久、渡部美都、石原桃子、太田克美、浅井章良
- Organizer
  日本ケミカルバイオロジー学会第14回年会
- Data Source
  KAKENHI-PROJECT-18H02559
[Presentation] Design and synthesis of novel linker-payload with S-trityl-L-cysteine derivative for antibody-drug conjugates2019
- Author(s)
  Taiki Ichida, Ryota Fukai, Yumeka Ikeda, Naohisa Ogo, Nao Miyoshi, and Akira Asai
- Organizer
  第24回静岡健康・長寿学術フォーラム（静岡）
- Data Source
  KAKENHI-PROJECT-17K08366
[Presentation] がん細胞選択性を指向したシステイン誘導体プロドラッグのデザインと合成2018
- Author(s)
  深井涼太、小郷尚久、山根正敬、三好奈央、浅井章良
- Organizer
  日本ケミカルバイオロジー学会第13回年会
- Data Source
  KAKENHI-PROJECT-17K08366
[Presentation] Structure-based design and evaluation of cysteine derivative prodrugs targeting cancer cells utilizing g-glutamyltransferase activity2018
- Author(s)
  Ryota Fukai, Naohisa Ogo, Masayoshi Yamane, Nao Miyoshi, and Akira Asai
- Organizer
  The 4th International Conference on Pharma and Food (ICPF2018)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08366
[Presentation] Foxp3阻害化合物の探索及び作用機序解析2018
- Author(s)
  園田祐大、小郷尚久、安藤隆幸、村岡大輔、浅井章良
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18H02559
[Presentation] がん治療を目指した Eg5 阻害剤封入リポソームの開発2017
- Author(s)
  森智哉、清水広介、成田雄大、阿形寿規、大塚和摩、小郷尚久、浅井章良、奥直人
- Organizer
  日本薬学会第137年会（仙台）
- Data Source
  KAKENHI-PROJECT-17K08366
[Presentation] Characterization of Aluminum Signal Transduction Pathway in AtALMT1 Expression Base on Chemical Genetics2017
- Author(s)
  WU LIUJIE，時澤睦朋，小郷尚久，浅井章良，小林佑理子，小山博之
- Organizer
  日本土壌肥料学会2017年度仙台大会
- Data Source
  KAKENHI-PROJECT-16K14870
[Presentation] Synthesis and evaluation of novel cysteine derivatives as next generation antitumor agents2016
- Author(s)
  Ryota Fukai, Naohisa Ogo, Masayoshi Yamane, Jun-ichi Sawada, and Akira Asai
- Organizer
  The 3rd International Conference on Pharma-Food
- Place of Presentation
  Shizuoka
- Year and Date
  2016-11-17
- Data Source
  KAKENHI-PROJECT-26460150
[Presentation] Profiling of Al-responsive signaling pathway regulating AtALMT1 by chemical screening2016
- Author(s)
  LIUJIE WU・河合　翼・小郷尚久・浅井章良・小林佑理子・小山博之
- Organizer
  日本土壌肥料学会2016年度佐賀大会
- Place of Presentation
  佐賀大学　佐賀市
- Year and Date
  2016-09-20
- Data Source
  KAKENHI-PROJECT-16K14870
[Presentation] 新規 KSP 阻害剤の創製－システイン誘導体の合成と構造活性相関－2015
- Author(s)
  小郷尚久、浅井章良
- Organizer
  第33回メディシナルケミストリーシンポジウム
- Place of Presentation
  幕張国際研修センター（千葉）
- Year and Date
  2015-11-25
- Invited
- Data Source
  KAKENHI-PROJECT-26460150
[Presentation] KSP阻害作用を有する新規システイン誘導体の抗がん活性2015
- Author(s)
  小郷尚久、三原寛貴、山根正敬、澤田潤一、浅井章良
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場（名古屋）
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-26460150
[Presentation] 新規システイン誘導体のKSP阻害に基づく次世代抗がん剤探索研究
- Author(s)
  小郷尚久、澤田潤一、石川吉伸、松野研司、橋本章弘、浅井章良
- Organizer
  日本ケミカルバイオロジー学会　第9回年会
- Place of Presentation
  大阪大学（大阪府）
- Year and Date
  2014-06-11 – 2014-06-13
- Data Source
  KAKENHI-PROJECT-26460150
[Presentation] 新規KSP阻害剤の創製 ‐システイン誘導体の合成と構造活性相関‐
- Author(s)
  小郷尚久、石川吉伸、松野研司、澤田潤一、橋本章弘、浅井章良
- Organizer
  第32回メディシナルケミストリーシンポジウム
- Place of Presentation
  神戸国際会議場（兵庫県）
- Year and Date
  2014-11-26 – 2014-11-28
- Data Source
  KAKENHI-PROJECT-26460150
[Presentation] Novel cysteine derivatives for the next generation anticancer agents acting on KSP
- Author(s)
  Naohisa Ogo, Jun-ichi Sawada, Yoshinobu Ishikawa, Kenji Matsuno, Akihiro Hashimoto, Akira Asai
- Organizer
  25th EORTC-NCI-AACR symposium Molecular targets and cancer therapeutics
- Place of Presentation
  Centre de Convencions Internacional Barcelona (Barcelona, Spain)
- Year and Date
  2014-11-18 – 2014-11-21
- Data Source
  KAKENHI-PROJECT-26460150

1. Asai Akira (60381737)

# of Collaborated Projects: 3 results

# of Collaborated Products: 37 results
2. 村岡大輔 (20608955)

# of Collaborated Projects: 3 results

# of Collaborated Products: 13 results
3. FUJITA Naoya (20280951)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. ASHIZAWA Tadashi (10443441)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. AKIYAMA Yasuto (70222552)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. ANDO Takayuki (40402226)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. KOBAYASHI Yuriko (40610952)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
8. SATO Shigeo

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. NAKAZAWA Youya

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. MISAWA Aya

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. TAKEMOTO Ai

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. OH-HARA Tomoko

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. TAKAMI Miho

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. MIYATA Kenichi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. OKITAKA Mina

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. SEKIGUCHI Takaya

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. TAKATORI Kazuki

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. FUSE Miho Jane

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. YOKOYAMA Hideshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. IKEDA Hiroaki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 滝川修

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. 菊地利明

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. 阿部貴志

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. 石川吉伸

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
25. 安井潔

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
26. 橋本博

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
27. 原幸大

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Ogo Naohisa 小郷 尚久

OGO Naohisa 小郷 尚久

Research Projects

Research Products

Co-Researchers

新規経口がん免疫治療薬の開発に向けたIDO1/TDO阻害剤の多面的構造最適化研究Principal Investigator

Principal Investigator

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独自のがん免疫療法シーズに基づく二重機能性キメラ化合物の開発

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Basic drug discovery research aimed at developing new combination cancer immunotherapies

Principal Investigator

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Development of novel antibody-drug conjugates utilizing the KSP inhibition of cysteine derivativesPrincipal Investigator

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Basic research for development of IDO/TDO dual inhibitors as new immuno-oncology drugs

Principal Investigator

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Development of novel KSP inhibitors highly selective for cancer cellsPrincipal Investigator

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Characterization of low pH and aluminum signal transduction based on chemical genetics

Principal Investigator

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Novel cysteine derivatives for the next generation anticancer agents acting on KSPPrincipal Investigator

Principal Investigator

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Development of a novel small-molecule compounds targeting cancer stem cells derived from malignant glioma

Principal Investigator

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Molecular analysis of metastasis-related tumor microenvironment and development of new anti-metastatic therapy

Principal Investigator

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Research Institution

[Journal Article] Combined therapeutic effect of YHO-1701 with PD-1 blockade is dependent on natural killer cell activity in syngeneic mouse models2023

Author(s)

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[Journal Article] Identification of serum and glucocorticoid-regulated kinase 1 as a regulator of signal transducer and activator of transcription 3 signaling2022

Author(s)

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[Journal Article] STAT3 inhibition suppresses adaptive survival of ALK-rearranged lung cancer cells through transcriptional modulation of apoptosis.2022

Author(s)

Journal Title

DOI

Data Source

Ogo Naohisa 小郷尚久

OGO Naohisa 小郷尚久