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MIYOSHI NORIKATSU  三吉 範克

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Miyoshi NorikatNorikatsu  三吉 範克

Miyoshi Norikatsu  三吉 範克

三吉 範克  ミヨシ ノリカツ

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Researcher Number 20528624
Other IDs
Affiliation (Current) 2025: 大阪大学, 大学院医学系研究科, 助教
Affiliation (based on the past Project Information) *help 2022 – 2024: 大阪大学, 大学院医学系研究科, 助教
2021: 大阪大学, 医学系研究科, 助教
2018 – 2019: 地方独立行政法人大阪府立病院機構大阪国際がんセンター(研究所), その他部局等, がん医療創生部プロジェクトリーダー
2017: 地方独立行政法人大阪府立病院機構大阪国際がんセンター(研究所), その他部局等, 特命プロジェクトリーダー
2016: 地方独立行政法人大阪府立病院機構大阪国際がんセンター(研究所), その他部局等, 医長 … More
2016: 地方独立行政法人大阪府立病院機構大阪府立成人病センター(研究所), その他部局等, 医長
2015: 地方独立行政法人大阪府立病院機構大阪府立成人病センター(研究所), その他部局等, その他
2009 – 2010: 大阪大学, 医学部附属病院, 医員
2009: 阪大, 医学部附属病院 Less
Review Section/Research Field
Principal Investigator
Basic Section 55010:General surgery and pediatric surgery-related / Digestive surgery / General surgery
Except Principal Investigator
Basic Section 55020:Digestive surgery-related / Basic Section 50010:Tumor biology-related / Digestive surgery / General surgery
Keywords
Principal Investigator
培養細胞 / 悪性腫瘍 / 初代培養がん細胞 / ex vivo / 間質 / 微小環境 / 腫瘍 / がん / 治療 / 基礎 … More / 臨床 / 癌 / 細胞培養 / 培養 / 癌細胞 / 治療効果予測 / 化学療法 / 癌治療 / 消化器癌 / 間葉系幹細胞 / 脂肪組織 / 幹細胞 / 手術 / 外科 / 脂肪 … More
Except Principal Investigator
大腸癌 / 癌幹細胞 / 癌関連線維芽細胞 / 初代培養 / 時計遺伝子 / アポトーシス / DEC1 / 大腸がん / リキッドバイオプシー / 微小転移 / がん関連線維芽細胞 / オルガノイド / 多様性 / 治療抵抗性 / 免疫抑制 / 癌微小環境 / 免疫 / 幹細胞 / 組織培養 / 5-アミノレブリン酸 / エクソソーム / マクロフアージ / 5-ALA / フローサイトメーター / 予後因子 / 制御性リンパ球 / 微小環境 / フェロトーシス / 癌局所免疫 / 腹膜播種 / 胃癌 / 遺伝子導入 / 創薬 Less
  • Research Projects

    (11 results)
  • Research Products

    (42 results)
  • Co-Researchers

    (35 People)
  •  Early detection of cancer micrometastasis and development of new treatment strategies

    • Principal Investigator
      藤野 志季
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 50010:Tumor biology-related
    • Research Institution
      Osaka University
  •  腫瘍微小環境モデルの構築と治療抵抗性メカニズムの解析Principal Investigator

    • Principal Investigator
      三吉 範克
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55010:General surgery and pediatric surgery-related
    • Research Institution
      Osaka University
  •  Investigating personalized chronotherapy through the regulation of clock genes expression related to cancer.

    • Principal Investigator
      南 壮一郎
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55020:Digestive surgery-related
    • Research Institution
      Osaka University
  •  大腸癌における特異的な新規がん関連線維芽細胞マーカーの同定

    • Principal Investigator
      加藤 伸弥
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55020:Digestive surgery-related
    • Research Institution
      Osaka University
  •  Exploring the Interaction Between Cancer Cells and the Cancer Microenvironment Aimed at Novel Therapies

    • Principal Investigator
      Fujino Shiki
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55020:Digestive surgery-related
    • Research Institution
      Osaka University
  •  Reconstruction and the analysis of tumor stroma using ex vivo tumor modelPrincipal Investigator

    • Principal Investigator
      Miyoshi NorikatNorikatsu
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55010:General surgery and pediatric surgery-related
    • Research Institution
      Osaka University
  •  Molecular mechanism in early establishment of peritoneal metastasis from gastric cancer.

    • Principal Investigator
      FUJIWARA Yoshiyuki
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      Tottori University
  •  patient-derived in vitro cancer model for personalized medicinePrincipal Investigator

    • Principal Investigator
      Miyoshi Norikatsu
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General surgery
    • Research Institution
      Osaka International Cancer Institute
  •  Assessment and evaluation of patient-derived adipogenic stem cellsPrincipal Investigator

    • Principal Investigator
      Miyoshi Norikatsu
    • Project Period (FY)
      2015 – 2016
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Digestive surgery
    • Research Institution
      Research Institute, Osaka Medical Center for Cancer and Cardiovascular Disaeses
  •  癌幹細胞の増幅と創薬応用を目指す未来型の探索研究

    • Principal Investigator
      関本 貢嗣
    • Project Period (FY)
      2009 – 2010
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      General surgery
    • Research Institution
      Osaka University
  •  癌細胞の再プログラミングと臨床応用のための開発研究Principal Investigator

    • Principal Investigator
      三吉 範克
    • Project Period (FY)
      2009
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Digestive surgery
    • Research Institution
      Osaka University

All 2024 2023 2022 2021 2019 2018 2017 2010 2009

All Journal Article Presentation

  • [Journal Article] Efficacy of transanal drainage tube in preventing anastomotic leakage after surgery for rectal cancer: A meta-analysis2023

    • Author(s)
      Fujino Shiki、Yasui Masayoshi、Ohue Masayuki、Miyoshi Norikatsu
    • Journal Title

      World Journal of Gastrointestinal Surgery

      Volume: 15 Issue: 6 Pages: 1202-1210

    • DOI

      10.4240/wjgs.v15.i6.1202

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K08709
  • [Journal Article] Cancer Stem Cells Persist Despite Cellular Damage, Emergence of the Refractory Cell Population2023

    • Author(s)
      Nagae Ayumi、Miyoshi Norikatsu、Fujino Shiki、Horie Masafumi、Yachida Shinichi、Sasaki Masaru、Sekido Yuki、Hata Tsuyoshi、Hamabe Atsushi、Ogino Takayuki、Takahashi Hidekazu、Uemura Mamoru、Yamamoto Hirofumi、Doki Yuichiro、Eguchi Hidetoshi
    • Journal Title

      Annals of Surgical Oncology

      Volume: 30 Issue: 11 Pages: 6913-6924

    • DOI

      10.1245/s10434-023-13849-x

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-23K08128, KAKENHI-PROJECT-21K08709
  • [Journal Article] Tumor-infiltrating T cells as a risk factor for lymph node metastasis in patients with submucosal colorectal cancer2023

    • Author(s)
      Kitakaze Masatoshi、Fujino Shiki、Miyoshi Norikatsu、Sekido Yuki、Hata Tsuyoshi、Ogino Takayuki、Takahashi Hidekazu、Uemura Mamoru、Mizushima Tsunekazu、Doki Yuichiro、Eguchi Hidetoshi
    • Journal Title

      Scientific Reports

      Volume: 13 Issue: 1 Pages: 2077-2077

    • DOI

      10.1038/s41598-023-29260-1

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K08709, KAKENHI-PROJECT-23K08128
  • [Journal Article] Metastases and treatment-resistant lineages in patient-derived cancer cells of colorectal cancer2023

    • Author(s)
      Fujino Shiki、Miyoshi Norikatsu、Ito Aya、Hayashi Rie、Yasui Masayoshi、Matsuda Chu、Ohue Masayuki、Horie Masafumi、Yachida Shinichi、Koseki Jun、Shimamura Teppei、Hata Tsuyoshi、Ogino Takayuki、Takahashi Hidekazu、Uemura Mamoru、Mizushima Tsunekazu、Doki Yuichiro、Eguchi Hidetoshi
    • Journal Title

      Communications Biology

      Volume: 6 Issue: 1 Pages: 1191-1191

    • DOI

      10.1038/s42003-023-05562-y

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-23K08128, KAKENHI-PROJECT-21K08709, KAKENHI-PLANNED-23H04938, KAKENHI-PROJECT-23K24941
  • [Journal Article] Fibroblast Activation Protein and Tertiary Lymphoid Structure in Colorectal Cancer Recurrence2022

    • Author(s)
      HAYASE SHIMON、MIYOSHI NORIKATSU、FUJINO SHIKI、YASUI MASAYOSHI、OHUE MASAYUKI、MINAMI SOICHIRO、KATO SHINYA、NAGAE AYUMI、SEKIDO YUKI、HATA TSUYOSHI、HAMABE ATSUSHI、OGINO TAKAYUKI、TAKAHASHI HIDEKAZU、UEMURA MAMORU、YAMAMOTO HIROFUMI、DOKI YUICHIRO、EGUCHI HIDETOSHI
    • Journal Title

      Anticancer Research

      Volume: 42 Issue: 12 Pages: 5897-5907

    • DOI

      10.21873/anticanres.16099

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K08709, KAKENHI-PROJECT-20K09056
  • [Journal Article] HNF1A regulates colorectal cancer progression and drug resistance as a downstream of POU5F12021

    • Author(s)
      Fujino Shiki、Miyoshi Norikatsu、Ito Aya、Yasui Masayoshi、Matsuda Chu、Ohue Masayuki、Uemura Mamoru、Mizushima Tsunekazu、Doki Yuichiro、Eguchi Hidetoshi
    • Journal Title

      Scientific Reports

      Volume: 11 Issue: 1 Pages: 10363-10363

    • DOI

      10.1038/s41598-021-89126-2

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20K09056, KAKENHI-PROJECT-21K08709
  • [Journal Article] Crenolanib Regulates ERK and AKT/mTOR Signaling Pathways in RAS/BRAF-Mutated Colorectal Cancer Cells and Organoids2021

    • Author(s)
      Fujino Shiki、Miyoshi Norikatsu、Ito Aya、Yasui Masayoshi、Ohue Masayuki、Ogino Takayuki、Takahashi Hidekazu、Uemura Mamoru、Matsuda Chu、Mizushima Tsunekazu、Doki Yuichiro、Eguchi Hidetoshi
    • Journal Title

      Molecular Cancer Research

      Volume: Feb12 Issue: 5 Pages: 812-822

    • DOI

      10.1158/1541-7786.mcr-20-0600

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K18145, KAKENHI-PROJECT-20K09056, KAKENHI-PROJECT-21K08709
  • [Journal Article] New marking method involving a light-emitting diode and power source device to localize gastrointestinal cancer in laparoscopic surgery2019

    • Author(s)
      Wada Y, Miyoshi N, Fujino S, Ohue M, Yasui M, Takahashi Y, Takahashi H, Nishimura J, Takenaka Y, Saso K, Tomokuni A, Sugimura K, Akita H, Takahashi H, Kobayashi S, Omori T, Miyata H, Yano M.
    • Journal Title

      Sci Rep

      Volume: -

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K10572
  • [Journal Article] Phenotypic heterogeneity of 2D organoid reflects clinical tumor characteristics2019

    • Author(s)
      Fujino S, Ito A, Ohue M, Yasui M, Mizusima T, Doki Y, Mori M, Miyoshi N
    • Journal Title

      Biochem Biophys Res Commun

      Volume: -

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K10572
  • [Journal Article] Oct4 gene expression in primary colorectal cancer promotes liver metastasis2019

    • Author(s)
      Fujino S, Miyoshi N
    • Journal Title

      Stem Cell Int

      Volume: -

    • Data Source
      KAKENHI-PROJECT-17K10572
  • [Journal Article] The POU5F1 gene expression in colorectal cancer: a novel prognostic marker.2018

    • Author(s)
      Miyoshi N, Fujino S, Ohue M, Yasui M, Takahashi Y, Sugimura K, Tomokuni A, Akita H, Kobayashi S, Takahashi H, Omori T, Miyata H, Yano M
    • Journal Title

      Surg Today

      Volume: in press Issue: 7 Pages: 709-715

    • DOI

      10.1007/s00595-018-1644-9

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K10203, KAKENHI-PROJECT-17K16542, KAKENHI-PROJECT-17K10572
  • [Journal Article] Platelet-derived growth factor receptor-beta gene expression relates to recurrence in colorectal cancer2018

    • Author(s)
      Fujino S., Miyoshi N., Ohue M., Takahashi Y., Yasui, M., Hata T., Matsuda C., Mizushima T., Doki Y., Mori M.
    • Journal Title

      Oncology Reports

      Volume: 39 Pages: 2178-2184

    • DOI

      10.3892/or.2018.6290

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K10572
  • [Journal Article] The POU5F1 gene expression in colorectal cancer: a novel prognostic marker2018

    • Author(s)
      Miyoshi N, Fujino S, Ohue M, Yasui M, Takahashi Y, Sugimura K, Tomokuni A, Akita H, Kobayashi S, Takahashi H, Omori T, Miyata H, Yano M.
    • Journal Title

      Surg Today

      Volume: 48 Pages: 709-715

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K10572
  • [Journal Article] Defined factors induced reprogramming of gastrointestinal cancer cells2010

    • Author(s)
      Miyoshi N., et al
    • Journal Title

      Proc Natl Acad Sci

      Volume: 107(1) Pages: 40-45

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21659303
  • [Journal Article] TGM2 is a novel marker for prognosis and therapeutic target in colorectal cancer2010

    • Author(s)
      Miyoshi N, et al
    • Journal Title

      Ann Surg Oncol

      Volume: 17 Pages: 967-972

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21659303
  • [Journal Article] J Surg Oncol2010

    • Author(s)
      Miyoshi N., et al
    • Journal Title

      SCRN1 is a novel maeker for prognosis in colorectal cancer.

      Volume: 101 Pages: 156-159

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21659303
  • [Journal Article] ATP11A is a novel predictive marker for metachronous metastasis of colorectal cancer2009

    • Author(s)
      Miyoshi N., et al
    • Journal Title

      Oncol Rep (In press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21659303
  • [Journal Article] TGM2 is a novel marker for prognosis in colorectal cancer2009

    • Author(s)
      Miyoshi N., et al
    • Journal Title

      Ann Surg Oncol (In press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21659303
  • [Journal Article] Notch pathway as candidate therapeutic target in Her2/Neu/ErdB2 receptor-negative breast tumors2009

    • Author(s)
      Miyoshi N., et al
    • Journal Title

      Oncol Rep 23

      Pages: 35-43

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21659303
  • [Journal Article] Abnormal expression of TRIB3 in colorectal cancer : a novel marker for prognosis2009

    • Author(s)
      Miyoshi N., et al
    • Journal Title

      Br J Cancer (In press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21659303
  • [Journal Article] Minute liver metastases from rectal carcinoid : a case report and review of the literature2009

    • Author(s)
      Miyoshi N., et al
    • Journal Title

      World Journal of Gastrointestinal Surgery (In press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21659303
  • [Journal Article] RGS16 is a marker for prognosis in colorectal cancer2009

    • Author(s)
      Miyoshi N., et al
    • Journal Title

      Ann Surg Oncol (In press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21659303
  • [Journal Article] SCRN1 is a novel maeker for prognosis in colorectal cancer2009

    • Author(s)
      Miyoshi N., et al
    • Journal Title

      J Surg Oncol (In press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21659303
  • [Journal Article] TDGF1 is a novel predictive marker for metachronous metastasis of colorectal cancer2009

    • Author(s)
      Miyoshi N., et al
    • Journal Title

      Int J Oncol (In press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21659303
  • [Journal Article] Defined factors induced reprogramming of gastrointestinal cancer cells2009

    • Author(s)
      Miyoshi N., et al
    • Journal Title

      PNAS (In press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21659303
  • [Journal Article] The properties and identification of cancer stem cells2009

    • Author(s)
      Miyoshi N., et al
    • Journal Title

      Surgery Today (In press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21659303
  • [Journal Article] Epithelial-mesenchymal transition with expression of SNAI1-induced chemoresistance in colorectal cancer2009

    • Author(s)
      Miyoshi N., et al
    • Journal Title

      Biochem Biophys Res Commun 390(3)

      Pages: 1061-1065

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21659303
  • [Presentation] 患者由来オルガノイドの異種移植モデルによる癌微小環境の解析2024

    • Author(s)
      加藤伸弥、三吉範克、藤野志季、竹田充伸、関戸悠紀、波多豪、浜部敦史、荻野崇之、植村守、山本浩文、土岐祐一郎、江口英利
    • Organizer
      第124回日本外科学会総会
    • Data Source
      KAKENHI-PROJECT-22K08824
  • [Presentation] 患者由来オルガノイドを用いた大腸癌がん関連線維芽細胞の解析2023

    • Author(s)
      加藤伸弥、三吉範克、藤野志季、浜部敦史、荻野崇之、高橋秀和、植村守、山本浩文、土岐祐一郎、江口英利
    • Organizer
      第78回日本消化器外科学会総会
    • Data Source
      KAKENHI-PROJECT-22K08824
  • [Presentation] Single-cell RNA sequencing of patient-derived organoid reveals treatment-induced tumor resistance through cancer stem cells2022

    • Author(s)
      Shiki Fujino; Aya Ito; Masayoshi Yasui; Chu Matsuda; Masayuki Ohue; Masafumi Horie; Shinichi Yachida; Yuichiro Doki; Hidetoshi Eguchi; Norikatsu Miyoshi
    • Organizer
      AACR Annual Meeting 2022
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K08709
  • [Presentation] Precision medicine using patient-derived organoid and genomic profiling in gastroenterological surgery2022

    • Author(s)
      三吉 範克,藤野 志季,関戸 悠紀,波多 豪,浜部 敦史,荻野 祟之,高橋 秀和,植村 守,山本 浩文,土岐 祐一郎,江口 英利
    • Organizer
      第81回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-21K08709
  • [Presentation] Cancer stem cell reproduce treatment-resistant cells2022

    • Author(s)
      藤野 志季,武田 和,團野 克樹,山本 慧,東口 公哉,野口 幸藏,豊田 泰弘,平尾 隆文,岡 義雄,堀江 真史,谷内田 真一,大植 雅之,土岐 祐一郎,江口 英利,三吉 範克
    • Organizer
      第81回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-21K08709
  • [Presentation] Heterogeneity inducible tumor stem cells relate distant metastasis and the treatment resistance2022

    • Author(s)
      Norikatsu Miyoshi; Shiki Fujino; Yuki Sekido; Tsuyoshi Hata; Takayuki Ogino; Hidekazu Takahashi; Mamoru Uemura; HIrofumi Yamamoto; Yuichiro Doki; Hidetoshi Eguchi
    • Organizer
      AACR Annual Meeting 2022
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K08709
  • [Presentation] 2次元培養オルガノイドを利用したシングルセル解析による癌多様性の解明2021

    • Author(s)
      藤野志季、武田和、團野克樹、山本慧、野口幸臧、豊田泰弘、徳永俊照、平尾隆文、杉本圭司、岡義雄、堀江真史、谷内田真一、大植雅之、土岐祐一郎、江口英利、三吉範克
    • Organizer
      第80回日本癌学会学術集会
    • Data Source
      KAKENHI-PROJECT-21K08709
  • [Presentation] 癌幹細胞の生み出す腫瘍不均一性と臨床的治療抵抗性の獲得2021

    • Author(s)
      三吉範克、藤野志季、荻野崇之、高橋秀和、植村守、山本浩文、水島恒和、土岐祐一郎、江口英利
    • Organizer
      第80回日本癌学会学術集会
    • Data Source
      KAKENHI-PROJECT-21K08709
  • [Presentation] Colorectal cancer stem cell expressing POU5F1 promotes liver metastasis2019

    • Author(s)
      Norikatsu Miyoshi
    • Organizer
      AACR
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K10572
  • [Presentation] Precision medicineを目指した初代培養法による治療効果予測2019

    • Author(s)
      三吉範克、藤野志季、高橋秀和、原口直紹、畑泰司、松田宙、水島恒和、森正樹、土岐祐一郎
    • Organizer
      第74回日本大腸肛門病学会学術集会
    • Data Source
      KAKENHI-PROJECT-17K10572
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      三吉範克
    • Organizer
      第77回日本癌学会
    • Data Source
      KAKENHI-PROJECT-17K10572
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      三吉範克
    • Organizer
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    • Data Source
      KAKENHI-PROJECT-17K10572
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    • Author(s)
      三吉範克
    • Organizer
      日本再生医療学会
    • Data Source
      KAKENHI-PROJECT-17K10572
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    • Author(s)
      三吉範克
    • Organizer
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    • Data Source
      KAKENHI-PROJECT-17K10572
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    • Author(s)
      Norikatsu Miyoshi
    • Organizer
      ESMO Asia
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K10572
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