Kashihara Toshihide 柏原俊英

… Alternative Names

KASHIHARA Toshihide 柏原俊英

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Researcher Number	20552334
Other IDs
Affiliation (Current)	2025: 北里大学, 薬学部, 准教授
Affiliation (based on the past Project Information) *help	2021 – 2024: 北里大学, 薬学部, 講師 2014 – 2018: 信州大学, 学術研究院医学系, 助教 2012 – 2013: 信州大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 48020:Physiology-related / General physiology / General pharmacology Except Principal Investigator General physiology
Keywords	Principal Investigator カゼインキナーゼ２ / L型カルシウムチャネル / ミュラー細胞 / YAP / βアレスチン / アンジオテンシンⅡ / 心不全 / タンパク質リン酸化酵素 / 心筋 / 網膜神経変性 … More / 糖代謝 / 糖尿病 / グリア細胞 / 網膜 / YAP/HIPPOシグナリング / メチルグリオキサール / YAPシグナリング / 高血糖 / 糖尿病網膜症 / 循環薬理 / カゼインキナーゼ2 / アンジオテンシン2 / 幼若心筋細胞 / 心臓 / 心機能 / 強心作用 / 陽性変力作用 / 心筋興奮収縮連関 / Ｌ型カルシウムチャネル / プロテインホスファターゼ２A / 興奮収縮連関 / T管 … More Except Principal Investigator 結合膜構造 / リアノジン受容体 / L型カルシウムチャネル / 骨格筋 / ジャンクトフィリン / Ｌ型カルシウムチャネル Less

網膜神経変性疾患におけるミュラー細胞のYAPの役割の解明Principal Investigator
- Principal Investigator
  
  柏原俊英
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48020:Physiology-related
- Research Institution
  Kitasato University
The role of the YAP/HIF-1a complex in the pathogenesis of diabetic retinopathyPrincipal Investigator
- Principal Investigator
  
  Kashihara Toshihide
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48020:Physiology-related
- Research Institution
  Kitasato University
The impact of a beta-arrestin-biased AT1 receptor agonist on positive inotropic effect in the immature heartPrincipal Investigator
- Principal Investigator
  
  Kashihara Toshihide
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Shinshu University
Physiological and pathophysiological roles of casein kinase 2 in the regulation of cardiac L-type Ca channelsPrincipal Investigator
- Principal Investigator
  
  KASHIHARA Toshihide
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General physiology
- Research Institution
  Shinshu University
Localization and function of L-type calcium channels in skeletal muscle is regulated by junctophilins.
- Principal Investigator
  
  NAKADA Tsutomu
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General physiology
- Research Institution
  Shinshu University
Analysis of molecular mechanisms underlying regulation of basal activity of t-tubular L-type Ca channels in ventricular myocytesPrincipal Investigator
- Principal Investigator
  
  KASHIHARA Toshihide
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General physiology
- Research Institution
  Shinshu University

All 2023 2022 2018 2017 2016 2015 2014 2013 2012 Other

All Journal Article Presentation

[Journal Article] PDGF-induced migration of synthetic vascular smooth muscle cells through c-Src-activated L-type Ca2+ channels with full-length CaV1.2 C-terminus2018
- Author(s)
  Xiaoguang Guo, Toshihide Kashihara, Tsutomu Nakada, Toshifumi Aoyama, Mitsuhiko Yamada
- Journal Title
  
  Pflugers Archiv - European Journal of Physiology
  
  Volume: 470 (6) Issue: 6 Pages: 909-921
- DOI
  10.1007/s00424-018-2114-3
- NAID
  130007812887
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08546, KAKENHI-PROJECT-18K06870
[Journal Article] Angiotensin II activates CaV1.2 Ca2+ channels through beta-arrestin2 and casein kinase 2 in mouse immature cardiomyocytes2017
- Author(s)
  Toshihide Kashihara, Tsutomu Nakada, Katsuhiko Kojima, Toshikazu Takeshita, Mitsuhiko Yamada
- Journal Title
  
  The Journal of Physiology
  
  Volume: in press Issue: 13 Pages: 4207-4225
- DOI
  10.1113/jp273883
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16K08546
[Journal Article] Transplantation of adipose tissue-derived stem cells improves cardiac contractile function and electrical stability in a rat myocardial infarction model.2015
- Author(s)
  Gautam M., Fujita D., Kimura K., Ichikawa H., Izawa A., Hirose M., Kashihara T., Yamada M., Takahashi M., Ikeda U., Shiba Y.
- Journal Title
  
  Journal of molecular and cellular cardiology
  
  Volume: 81 Pages: 139-149
- DOI
  10.1016/j.yjmcc.2015.02.012
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26860145, KAKENHI-PROJECT-15K09146, KAKENHI-PROJECT-26461062, KAKENHI-PROJECT-26293182
[Journal Article] Cardiac overexpression of constitutively active Gαq causes angiotensin II type1 receptor activation, leading to progressive heart failure and ventricular arrhythmias in transgenic mice2014
- Author(s)
  Matsushita N, Kashihara T, Shimojo H, Suzuki S, Nakada T, Takeishi Y, Mende U, Taira E, Yamada M, Sanbe A, Hirose M
- Journal Title
  
  PLoS One
  
  Volume: 9 Issue: 8 Pages: e106354-e106354
- DOI
  10.1371/journal.pone.0106354
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24591100, KAKENHI-PROJECT-26860145
[Journal Article] TRPM4 channels mediate hypertonicity-induced, Ca2+-impermeable, non-selective cation currents in a cervical cancer cell line, HeLa cells2014
- Author(s)
  Gomi S., Nakada T., Kashihara T., Ikeda U., Yamada M.
- Journal Title
  
  Shinshu Medical Journal
  
  Volume: 62 Pages: 33-44
- NAID
  130004551913
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790210
[Journal Article] β2-Adrenergic and M2-muscarinic receptors decrease basal t-tubular L-type Ca2+ channel activity and suppress ventricular contractility in heart failure.2014
- Author(s)
  Kashihara T, Hongo M, et al.
- Journal Title
  
  European Journal of Pharmacology
  
  Volume: 724 Pages: 122-131
- DOI
  10.1016/j.ejphar.2013.12.037
- NAID
  120007110580
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24500813, KAKENHI-PROJECT-24790210
[Journal Article] Novel regulation pf cardiac metabolism and homeostasis by the adrenomedullin- receptor activity-modifying protein 2 system2013
- Author(s)
  Takahiro Yoshizawa, Takayuki Sakurai, Akiko Kamiyoshi, Yuka Ichikawa-Shindo, Hisaka Kawate, Yasuhiro Iesato, Teruhide Koyama, Ryuichi Uetake, Lei Yang, Akihiro Yamauchi, Megumu Tanaka, Yuichi Toriyama, Kyoko Igarashi, Tsutomu Nakada, Toshihide Kashihara, Mitsuhiko Yamada, Hayato Kawakami, Hiroki Nakanishi, Ryo Taguchi, Tsuyoshi Nakanishi, Hiroshi Akazawa, Takayuki Shindo
- Journal Title
  
  Hypertension
  
  Volume: 61 Issue: 2 Pages: 341-351
- DOI
  10.1161/hypertensionaha.111.00647
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10J07696, KAKENHI-PROJECT-11J10361, KAKENHI-PROJECT-22590193, KAKENHI-PROJECT-23390213, KAKENHI-PROJECT-23590456, KAKENHI-PROJECT-23790074, KAKENHI-PROJECT-23790288, KAKENHI-PROJECT-24659390, KAKENHI-PROJECT-24790210, KAKENHI-PUBLICLY-23116503
[Journal Article] Two mechanistically distinct effects of dihydropyridine nifedipine on CaV1.2 L-type Ca2+ channels revealed by Timothy syndrome mutation2012
- Author(s)
  Sheng X, Nakada T, Kobayashi M, Kashihara T, Shibazaki T, Horiuchi-Hirose M, Gomi S, Hirose M, Aoyama T, Yamada M.
- Journal Title
  
  European journal of pharmacology
  
  Volume: 685 Issue: 1-3 Pages: 15-23
- DOI
  10.1016/j.ejphar.2012.04.029
- NAID
  120007110525
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790210
[Journal Article] Nicorandil prevents Gαq-induced progressive heart failure and ventricular arrhythmias in transgenic mice2012
- Author(s)
  Hirose M, Takeishi Y, Nakada T, Shimojo H, Kashihara T, Nishio A, Suzuki S, Mende U, Matsumoto K, Matsushita N, Taira E, Sato F, Yamada M
- Journal Title
  
  PLoS One
  
  Volume: 7 Issue: 12 Pages: e52667-e52667
- DOI
  10.1371/journal.pone.0052667
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591100, KAKENHI-PROJECT-24790210
[Journal Article] The proximal C-terminus of α1C subunits is necessary for junctional membrane targeting of cardiac L-type calcium channels.2012
- Author(s)
  Nakada T., Flucher E. B., Kashihara T., Sheng X., Shibazaki T., Horiuchi-Hirose M., Gomi S., Hirose M., Yamada M.
- Journal Title
  
  The Biochemical journal
  
  Volume: 448 Issue: 2 Pages: 221-231
- DOI
  10.1042/bj20120773
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790210
[Presentation] Methylglyoxal誘発ラット網膜傷害におけるミュラー細胞のYAPの発現変化2023
- Author(s)
  奥山祐未、柏原俊英、矢崎真由子、萩原歩美、井上紗栄、中原努
- Organizer
  第148回日本薬理学会関東部会
- Data Source
  KAKENHI-PROJECT-21K06787
[Presentation] ラットNMDA誘発網膜神経傷害モデルにおけるYAPの発現変化2022
- Author(s)
  柏原俊英、森田祐生、平島枝里、森田茜、中原努
- Organizer
  第42回日本眼薬理学会
- Data Source
  KAKENHI-PROJECT-21K06787
[Presentation] c-Srcによる平滑筋型CaV1.2 L型Ca2+チャネル活性化の分子機構の解析2018
- Author(s)
  柏原俊英、郭暁光、中田勉、山田充彦
- Organizer
  第135回日本薬理学会関東部会
- Data Source
  KAKENHI-PROJECT-16K08546
[Presentation] Angiotensin II increases Ca2+ transients by activating CaV1.2 Ca2+ channels through casein kinase 2 in immature cardiomyocytes2018
- Author(s)
  Toshihide Kashihara, Tsutomu Nakada, Mitsuhiko Yamada
- Organizer
  第95回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-16K08546
[Presentation] PDGF induces migration of synthetic vascular smooth muscle cells through c-Src-dependent activation of full-length CaV1.2 L-type Ca2+ channels2018
- Author(s)
  Toshihide Kashihara, Xiaoguang Guo, Tsutomu Nakada, Mitsuhiko Yamada
- Organizer
  18th WORLD CONGRESS OF BASICAL PHARMACOLOGY
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08546
[Presentation] PDGFはc-Src依存性に全長型CaV1.2L型Ca2+チャネルを活性化して血管平滑筋細胞を遊走させる2018
- Author(s)
  柏原俊英、郭暁光、中田勉、山田充彦
- Organizer
  第138回日本薬理学会関東部会
- Data Source
  KAKENHI-PROJECT-16K08546
[Presentation] Stimulation of AT1 angiotensin receptors activates CaV1.2 L-type Ca2+ channels through beta-arrestin2 and casein kinase 2 in immature cardiomyocytes.2017
- Author(s)
  Toshihide Kashihara, Tsutomu Nakada, Mitsuhiko Yamada
- Organizer
  Biophysical Society 61st Annual Meeting
- Place of Presentation
  New Orleans, LA, USA
- Year and Date
  2017-02-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08546
[Presentation] Angiotensin II activates CaV1.2 L-type Ca2+ channels in immature cardiomyocytes2017
- Author(s)
  Toshihide Kashihara, Tsutomu Nakada, Mitsuhiko Yamada
- Organizer
  第94回日本生理学会大会
- Place of Presentation
  静岡県浜松市浜松アクトシティコングレスセンター
- Year and Date
  2017-03-28
- Data Source
  KAKENHI-PROJECT-16K08546
[Presentation] The molecular mechanism by which angiotensin II activates CaV1.2 L-type Ca2+ channels in immature cardiomyocytes2017
- Author(s)
  Toshihide Kashihara, Tsutomu Nakada, Mitsuhiko Yamada
- Organizer
  20th International Symposium on Calcium Binding Proteins and Calcium Function in Health and Disease
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08546
[Presentation] Angiotensin II increases twitch Ca2+ transients by activating L-type CaV1.2 Ca2+ channels in immature cardiomyocytes2017
- Author(s)
  Toshihide Kashihara
- Organizer
  心血管代謝週間2017
- Data Source
  KAKENHI-PROJECT-16K08546
[Presentation] Platelet-derived growth factor activates CaV1.2 L-type Ca2+ channels through c-Src in vascular smooth muscle cells2017
- Author(s)
  Toshihide Kashihara, Xiaoguang Guo, Tsutomu Nakada, Mitsuhiko Yamada
- Organizer
  第90回日本薬理学会年会
- Place of Presentation
  長崎県長崎市長崎ブリックホール
- Year and Date
  2017-03-15
- Data Source
  KAKENHI-PROJECT-16K08546
[Presentation] 心室筋活動電位中のL型Ca2+チャネル電流波形を決める分子機構の解析2017
- Author(s)
  柏原俊英、郭暁光、中田勉、山田充彦
- Organizer
  第27回日本循環薬理学会
- Data Source
  KAKENHI-PROJECT-16K08546
[Presentation] 幼若心筋細胞でアンジオテンシンⅡがカゼインキナーゼ２α’βを活性化させる分子機構の解明2016
- Author(s)
  柏原俊英、中田勉、山田充彦
- Organizer
  第26回日本循環薬理学会
- Place of Presentation
  長野県松本市信州大学医学部付属病院
- Data Source
  KAKENHI-PROJECT-16K08546
[Presentation] Angiotensin II activates L-type Ca2+ channels through removing inhibition of casein kinase 2α’β by p27KIP1 in immature cardiac myocytes2016
- Author(s)
  Toshihide Kashihara, Tsutomu Nakada, Mitsuhiko Yamada
- Organizer
  第89回日本薬理学会年会
- Place of Presentation
  神奈川県横浜市西区　パシフィコ横浜会議センター
- Year and Date
  2016-03-09
- Data Source
  KAKENHI-PROJECT-26860145
[Presentation] カゼインキナーゼ2による幼若心筋細のL型Ca2+チャネル活性化の分子機構2015
- Author(s)
  柏原俊英、中田勉、山田充彦
- Organizer
  第25回日本循環薬理学会
- Place of Presentation
  奈良県奈良市水門町　東大寺総合文化センター金鐘ホール
- Year and Date
  2015-12-04
- Data Source
  KAKENHI-PROJECT-26860145
[Presentation] Regulation of the basal activity of Ca_V1.2 cardiac L-type Ca^<2+> channels by casein kinase 2α'β2014
- Author(s)
  Toshihide Kashihara, Tsutomu Nakada, Mitsuhiko Yamada
- Organizer
  第87回日本薬理学会年会
- Place of Presentation
  仙台国際センター
- Year and Date
  2014-03-19
- Data Source
  KAKENHI-PROJECT-24790210
[Presentation] Regulation of the basal activity of CaV1.2 cardiac L-type Ca2+ channels by casein kinase 2 α’β2014
- Author(s)
  Toshihide Kashihara, Tsutomu Nakada, Mitsuhiko Yamada
- Organizer
  第87回日本薬理学会年会
- Place of Presentation
  東北大学百周年記念会館（宮城県仙台市）
- Data Source
  KAKENHI-PROJECT-24790210
[Presentation] Casein Kinase 2α’β Determines the Basal Activity of CaV1.2 Cardiac L-type Ca2+ Channels2014
- Author(s)
  Toshihide Kashihara, Gomi Shimmon, Mitsuhiko Yamada
- Organizer
  第78回日本循環器学会学術集会
- Place of Presentation
  東京国際フォーラム（東京都千代田区）
- Data Source
  KAKENHI-PROJECT-24790210
[Presentation] ジャンクトフィリンはCaV1.1サブユニットのC末端と結合し，骨格筋L型カルシウムチャネルの局在を制御する2014
- Author(s)
  中田勉，Bernhard E Flucher，柏原俊英，小松雅俊，山田充彦
- Organizer
  第91回日本生理学会大会
- Place of Presentation
  鹿児島大学（鹿児島県鹿児島市）
- Data Source
  KAKENHI-PROJECT-24590271
[Presentation] 横紋筋L型カルシウムチャネルの結合膜局在化機構2014
- Author(s)
  中田勉，Bernhard E Flucher，柏原俊英，小松雅俊，山田充彦
- Organizer
  第87回日本薬理学会年会
- Place of Presentation
  仙台国際センター（宮城県仙台市）
- Data Source
  KAKENHI-PROJECT-24590271
[Presentation] Casein Kinase 2α'βDetermines the Basal Activity of Ca_V1.2 Cardiac L-type Ca^<2+> Channels2014
- Author(s)
  Toshihide Kashihara, Gomi Shimmon, Mitsuhiko Yamada
- Organizer
  第78回日本循環器学会学術集会
- Place of Presentation
  日東京国際会議場
- Year and Date
  2014-03-23
- Data Source
  KAKENHI-PROJECT-24790210
[Presentation] AT1アンジオテンシンⅡ受容体／βアレスチン2バイアスシグナルはα’β型カゼインキナーゼ2の活性化を介して幼弱心筋細胞のL型Ca2+チャネルを活性化させる2014
- Author(s)
  柏原俊英、中田勉、郭暁光、山田充彦
- Organizer
  第24回日本循環薬理学会
- Place of Presentation
  山形市双葉町　山形テルサ
- Year and Date
  2014-12-05
- Data Source
  KAKENHI-PROJECT-26860145
[Presentation] 慢性的で過剰なβ_1アドレナリン受容体刺激が心室筋の興奮収縮連関を修飾する分子機序について2013
- Author(s)
  柏原俊英、中田勉、五味志文、弘瀬雅教、山田充彦
- Organizer
  第90回日本生理学会大会
- Place of Presentation
  タワーホール船堀
- Year and Date
  2013-03-29
- Data Source
  KAKENHI-PROJECT-24790210
[Presentation] カゼインキナーゼ2による心筋CaV1.2L型Ca2+チャネルの基礎活性制御の分子機構の解析2013
- Author(s)
  柏原俊英、中田勉、山田充彦
- Organizer
  第23回日本循環薬理学会
- Place of Presentation
  福岡大学メディカルホール（福岡県福岡市）
- Data Source
  KAKENHI-PROJECT-24790210
[Presentation] カゼインキナーゼ2による心筋Ca_V1.2L型Ca^<2+>チャネルの基礎活性制御の分子機構の解析2013
- Author(s)
  柏原俊英、中田勉、山田充彦
- Organizer
  第23回日本循環薬理学会
- Place of Presentation
  福岡大学
- Year and Date
  2013-12-06
- Data Source
  KAKENHI-PROJECT-24790210
[Presentation] Junctophilin knockdown alters the localization and function of L-type calcium channels and ryanodine receptors in C2C12 myotubes.2013
- Author(s)
  Tsutomu Nakada, Bernhard Flucher, Toshihide Kashihara, Gomi Simmon, Mitsuhiko Yamada
- Organizer
  第86回日本薬理学会年会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-24590271
[Presentation] カゼインキナーゼ2による心筋型L型Ca2+チャネルの基礎活性制御の分子機構2013
- Author(s)
  柏原俊英、中田勉、五味志文、山田充彦
- Organizer
  第30回日本心電学会学術集会
- Place of Presentation
  リンクステーション青森（青森県弘前市）
- Data Source
  KAKENHI-PROJECT-24790210
[Presentation] CaチャネルアゴニストFPL64176の作用機序の検討2013
- Author(s)
  五味志文、柏原俊英、中田勉、池田宇一、山田充彦
- Organizer
  第129回日本薬理学会関東部会
- Place of Presentation
  順天堂大学本郷キャンパス（東京都文京区）
- Data Source
  KAKENHI-PROJECT-24790210
[Presentation] カゼインキナーゼ2による心筋型L型Ca^<2+>チャネルの基礎活性制御の分子機構2013
- Author(s)
  柏原俊英、中田勉、五味志文、山田充彦
- Organizer
  第30回日本心電学会学術集会
- Place of Presentation
  リンクステーションホール青森
- Year and Date
  2013-10-11
- Data Source
  KAKENHI-PROJECT-24790210
[Presentation] Effect of junctophilin knockdown on the localization and function of L-type calcium channels and ryanodine receptors in skeletal myotubes.2013
- Author(s)
  Tsutomu Nakada, Bernhard Flucher, Toshihide Kashihara, Gomi Simmon, Mitsuhiko Yamada
- Organizer
  第90回日本生理学会大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24590271
[Presentation] カゼインキナーゼ2によるCa_V1.2心筋型L型Ca^<2+>チャネルの基礎活性の制御2013
- Author(s)
  柏原俊英、中田勉、五味志文、山田充彦
- Organizer
  第86回日本薬理学会年会
- Place of Presentation
  福岡国際会議場
- Year and Date
  2013-03-21
- Data Source
  KAKENHI-PROJECT-24790210
[Presentation] スタウロスポリン感受性キナーゼとカゼインキナーゼ2による心室筋L型Caチャネルの基礎活性の制御2012
- Author(s)
  柏原俊英、中田勉、五味志文、山田充彦
- Organizer
  第29回日本心電学会学術集会
- Place of Presentation
  幕張メッセ国際会議場
- Year and Date
  2012-10-12
- Data Source
  KAKENHI-PROJECT-24790210
[Presentation] Regulation of L-type Ca2+ channels by angiotensin II type 1 receptor/beta-arrestin-2 biased signaling through casein kinase 2 in immature cardiomyocytes
- Author(s)
  Toshihide Kashihara, Tsutomu Nakada, Xiaoguang Guo, Mitsuhiko Yamada
- Organizer
  第92回日本生理学会大会
- Place of Presentation
  神戸市中央区　神戸国際会議場
- Year and Date
  2015-03-21 – 2015-03-23
- Data Source
  KAKENHI-PROJECT-26860145
[Presentation] Angiotensin II type 1 receptor/betaarrestin2 biased signaling activates L-type Ca2+ channels in immature cardiac myocytes
- Author(s)
  Toshihide Kashihara, Tsutomu Nakada, Xiaoguang Guo, Mitsuhiko Yamada
- Organizer
  第88回日本薬理学会年会
- Place of Presentation
  名古屋市熱田区　名古屋国際会議場
- Year and Date
  2015-03-18 – 2015-03-20
- Data Source
  KAKENHI-PROJECT-26860145
[Presentation] カゼインキナーゼ2によるCaV1.2心筋型L型Ca2+チャネルの基礎活性の制御
- Author(s)
  柏原俊英、中田勉、五味志文、山田充彦
- Organizer
  第86回日本薬理学会年会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-24790210
[Presentation] L型カルシウムチャネルおよびリアノジン受容体の骨格筋細胞内局在と機能に対するジャンクトフィリンの発現抑制の影響
- Author(s)
  中田勉、ブルナルド　フルハー、柏原俊英、五味志文、山田充彦
- Organizer
  第86回日本薬理学会年会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24790210
[Presentation] 慢性的で過剰なβ1アドレナリン受容体刺激が心室筋の興奮収縮連関を修飾する分子機序について
- Author(s)
  柏原俊英、中田勉、五味志文、弘瀬雅教、山田充彦
- Organizer
  第90回日本生理学会大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24790210
[Presentation] 骨格筋のL型カルシウムチャネルとリアノジン受容体の局在・機能に対するジャンクトフィリンの発現抑制の影響
- Author(s)
  中田勉、ブルナルド　フルハー、柏原俊英、五味志文、山田充彦
- Organizer
  第90回日本生理学会大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24790210
[Presentation] スタウロスポリン感受性キナーゼとカゼインキナーゼ２による心室筋Ｌ型Ｃａチャネルの基礎活性の制御
- Author(s)
  柏原俊英、中田勉、五味志文、山田充彦
- Organizer
  第29回日本心電学会学術集会
- Place of Presentation
  千葉
- Data Source
  KAKENHI-PROJECT-24790210
[Presentation] Failure to deactivate ventricular L-type Ca2+ channels in the phase 3 hyperpolarization is the direct cause of early afterdepolarization and torsade de pointes
- Author(s)
  Toshihide Kashihara, Mitsuhiko Yamada
- Organizer
  第29回日本不整脈学会学術大会／第31回日本心電学会学術集会合同学術大会
- Place of Presentation
  東京都港区　ザ・プリンスパークタワー東京
- Year and Date
  2014-07-22 – 2014-07-25
- Data Source
  KAKENHI-PROJECT-26860145

1. NAKADA Tsutomu (70452141)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
2. YAMADA Mitsuhiko (10263237)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
3. SUZUKI Suechika (10082174)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 竹石恭知

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
5. 鈴木聡

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
6. 本郷実

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kashihara Toshihide 柏原 俊英

KASHIHARA Toshihide 柏原 俊英

Research Projects

Research Products

Co-Researchers

網膜神経変性疾患におけるミュラー細胞のYAPの役割の解明Principal Investigator

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The role of the YAP/HIF-1a complex in the pathogenesis of diabetic retinopathyPrincipal Investigator

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The impact of a beta-arrestin-biased AT1 receptor agonist on positive inotropic effect in the immature heartPrincipal Investigator

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Physiological and pathophysiological roles of casein kinase 2 in the regulation of cardiac L-type Ca channelsPrincipal Investigator

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Localization and function of L-type calcium channels in skeletal muscle is regulated by junctophilins.

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Analysis of molecular mechanisms underlying regulation of basal activity of t-tubular L-type Ca channels in ventricular myocytesPrincipal Investigator

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[Journal Article] PDGF-induced migration of synthetic vascular smooth muscle cells through c-Src-activated L-type Ca2+ channels with full-length CaV1.2 C-terminus2018

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NAID

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[Journal Article] Angiotensin II activates CaV1.2 Ca2+ channels through beta-arrestin2 and casein kinase 2 in mouse immature cardiomyocytes2017

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[Journal Article] Transplantation of adipose tissue-derived stem cells improves cardiac contractile function and electrical stability in a rat myocardial infarction model.2015

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[Journal Article] Cardiac overexpression of constitutively active Gαq causes angiotensin II type1 receptor activation, leading to progressive heart failure and ventricular arrhythmias in transgenic mice2014

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[Journal Article] TRPM4 channels mediate hypertonicity-induced, Ca2+-impermeable, non-selective cation currents in a cervical cancer cell line, HeLa cells2014

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NAID

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[Journal Article] β2-Adrenergic and M2-muscarinic receptors decrease basal t-tubular L-type Ca2+ channel activity and suppress ventricular contractility in heart failure.2014

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NAID

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[Journal Article] Novel regulation pf cardiac metabolism and homeostasis by the adrenomedullin- receptor activity-modifying protein 2 system2013

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[Journal Article] Two mechanistically distinct effects of dihydropyridine nifedipine on CaV1.2 L-type Ca2+ channels revealed by Timothy syndrome mutation2012

Author(s)

Kashihara Toshihide 柏原俊英

KASHIHARA Toshihide 柏原俊英