MOTOYAMA Hiroaki 本山博章

Researcher Number	20569587
Affiliation (based on the past Project Information) *help	2014 – 2019: 信州大学, 学術研究院医学系(医学部附属病院), 助教 2011 – 2013: 信州大学, 医学部附属病院, 助教 2010: 信州大学, 医学部・附属病院, 助教(特定雇用) 2010: 信州大学, 医学部附属病院, 助教(特定雇用)
Review Section/Research Field	Except Principal Investigator Digestive surgery
Keywords	Except Principal Investigator 再生医療 / 外科 / 分化転換 / 肝再生 / 肝臓外科学 / 臓器特異的幹細胞 / 肝組織内在性幹細胞 / 液性因子 / 組織特異的幹細胞 / NO誘導 … More / NOS / ALPPS / 化学療法 / オートファジー / 薬物療法 / 分子標的治療 / 抗癌剤治療 / 胆管癌 / 膵臓外科 / β細胞 / 糖尿病 / 転写因子 / インスリン産生細胞 / リプログラミング / 細胞間相互作用 / 遺伝子治療 / 組織幹細胞 / 門脈結紮(塞栓) / 再生医学 / 骨髄細胞 / 移植・再生医療 / 骨髄移植 / 移植医療 Less

Analysis of promoting factor of liver regeneration in ALPPS
- Principal Investigator
  
  Shimizu Akira
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Shinshu University
Isolation of hepatic progenitor cells using specific surface molecules
- Principal Investigator
  
  Kobyashi Akira
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Shinshu University
Development of a novel peptide-based therapy for cholangiocarcinoma
- Principal Investigator
  
  MIYAGAWA Shin-ichi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Digestive surgery
- Research Institution
  Shinshu University
New modality for cell-replacement therapy using adult liver-derived progenitor cells for post-pancreatectomy diabetic patients.
- Principal Investigator
  
  KOBAYASHI Akira
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Shinshu University
The analysis of liver-to-pancreas reprogramming based on cellular interaction
- Principal Investigator
  
  KOBAYASHI Akira
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Shinshu University
Isolation and characterization of portal branch ligation-stimulated liver-specific stem cells
- Principal Investigator
  
  MIYAGAWA Shinichi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Digestive surgery
- Research Institution
  Shinshu University
New therapeutic approach with bone marrow cell for hereditary liver diseases
- Principal Investigator
  
  NAKATA Takenari
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Shinshu University

All 2019 2018 2013 2012 2011 2010 2009 Other

All Journal Article Presentation

[Journal Article] Treatment with specific soluble factors promotes the functional maturation of transcription factor-mediated, pancreatic transdifferentiated cells2018
- Author(s)
  Motoyama Hiroaki、Kobayashi Akira、Yokoyama Takahide、Shimizu Akira、Sakai Hiroshi、Notake Tsuyoshi、Fukushima Kentaro、Miyagawa Shin-ichi
- Journal Title
  
  PLOS ONE
  
  Volume: 13 Issue: 5 Pages: e0197175-e0197175
- DOI
  10.1371/journal.pone.0197175
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K10665, KAKENHI-PROJECT-15K10160
[Journal Article] Impaired degradation followed by enhanced recycling of epidermal growth factor receptor caused by hypo-phosphorylation of tyrosine 1045 in RBE cells.2012
- Author(s)
  Gui A, Kobayashi A, Motoyama H, Kitazawa M, Takeoka M, Miyagawa S.
- Journal Title
  
  BMC Cancer
  
  Volume: 12 Issue: 1 Pages: 179-179
- DOI
  10.1186/1471-2407-12-179
- NAID
  120007108250
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591516
[Journal Article] Isolation and characterization of portal branch ligation-stimulated Hmga2-positive bipotent hepatic progenitor cells2010
- Author(s)
  Sakai H, Motoyama H, Miyagaw a S., et al.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 403 Pages: 298-304
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591516
[Journal Article] Isolation and characterization of portal branch ligation-stimulated Hmga2-positive bipotent hepatic progenitor cells2010
- Author(s)
  Sakai H, Tagawa Y, Tamai M, Motoyama H, Ogawa S, Soeda J, Nakata T, Miyagawa S
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 403(3-4) Pages: 298-304
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390375
[Journal Article] Isolation and characterization of portal branch ligation-stimulated Hmga2-positive bipotent hepatic progenitor cells.2010
- Author(s)
  Sakai H, Tagawa Y, Tamai M, Motoyama H, Ogawa S, Soeda J, Nakata T, Miyagawa S.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 403(3-4) Issue: 3-4 Pages: 298-304
- DOI
  10.1016/j.bbrc.2010.11.021
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591516
[Journal Article] Isolation and characterization of portal branch ligation-stimulated Hmga2-positive bipotent hepatic progenitor cells.2010
- Author(s)
  Sakai H, Tagawa Y, Tamai M, Motoyama H, Ogawa S, Soeda J, Nakata T, Miyagawa S.
- Journal Title
  
  Biochem Biophys Res Commun. 17;403
  
  Pages: 298-304
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591604
[Journal Article] Isolation and characterization of portal branch ligation-stimulated Hmga2-positive bipotent hepatic progenitor cells.2010
- Author(s)
  Sakai H, Tagawa Y, Tamai M, Motoyama H, Ogawa S, Soeda J, Nakata T, Miyagawa S.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 403 Pages: 298-304
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591604
[Journal Article] Isolation and characterization of portal branch ligation-stimulated Hmga2-positive bipotent hepatic progenitor cells2010
- Author(s)
  Sakai H, Motoyama H, Miyagawa S., et al.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 403 Pages: 298-304
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390375
[Journal Article] In vitro reprogramming of adult hepatocytes into insulin-producing cells without viral vectors2009
- Author(s)
  Motoyama H, Ogawa S, Kubo A, Miwa S, Nakayama J, Tagawa Y, Miyagawa S
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 385(1) Pages: 123-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390375
[Journal Article] In vitro reprogramming of adult hepatocytes into insulin-producing cells without viral vectors.2009
- Author(s)
  Motoyama H, Miyagawa S., et al
- Journal Title
  
  Biochem Biophys Res Commun. 385
  
  Pages: 123-128
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390375
[Journal Article] In vitro reprogramming of adult hepatocytes into insulin-producing cells without viral vectors.2009
- Author(s)
  Motoyama H, Ogawa S, Kubo A, Miwa S, Nakayama J, Tagawa Y, Miyagawa S.
- Journal Title
  
  Biochem Biophys Res Commun. 385(1)
  
  Pages: 123-128
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591604
[Presentation] Liver-to-pancreas transdifferentiationに寄与するniche factorの同定2019
- Author(s)
  本山博章
- Organizer
  第119回日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-17K10665
[Presentation] Liver-to-pancreas transdifferentiationに寄与するniche factorの同定2019
- Author(s)
  本山博章
- Organizer
  第119回日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-17K10665
[Presentation] Liver-to-pancreas reprogramming - 膵切除後内分泌機能不全への応用 -2013
- Author(s)
  本山博章
- Organizer
  第113回日本外科学会総会
- Place of Presentation
  福岡
- Year and Date
  2013-04-12
- Data Source
  KAKENHI-PROJECT-22591516
[Presentation] Liver-to-pancreas reprogramming - 膵切除後内分泌機能不全への応用 -2013
- Author(s)
  本山博章
- Organizer
  第113回日本外科学会総会
- Place of Presentation
  福岡市
- Data Source
  KAKENHI-PROJECT-22591516
[Presentation] Induction of pancreatic β-like cells from hepatic cells.2012
- Author(s)
  本山博章
- Organizer
  第35回日本分子生物学会総会
- Place of Presentation
  福岡
- Year and Date
  2012-12-14
- Data Source
  KAKENHI-PROJECT-22591516
[Presentation] Induction of pancreatic β-like cells from hepatic cells2012
- Author(s)
  本山博章
- Organizer
  第35回日本分子生物学会総会
- Place of Presentation
  福岡市
- Data Source
  KAKENHI-PROJECT-22591516
[Presentation] Liver-to-pancreas reprogramming膵切除後内分泌機能不全への応用2011
- Author(s)
  本山博章
- Organizer
  第66回日本消化器外科学会
- Place of Presentation
  名古屋
- Year and Date
  2011-07-15
- Data Source
  KAKENHI-PROJECT-21390375
[Presentation] A Useful Non-viral Procedure to Induce Liver-to-pancreas Reprogramming to Complement Post-operative Pancreatic Endocrine Dysfunction2011
- Author(s)
  本山博章
- Organizer
  第17回日本遺伝子治療学会
- Place of Presentation
  福岡
- Year and Date
  2011-07-17
- Data Source
  KAKENHI-PROJECT-22591516
[Presentation] A Useful Non-viral Procedure to Induce Liver-to-pancreas Reprogramming to Complement Post-operative Pancreatic Endocrine Dysfunction2011
- Author(s)
  本山博章
- Organizer
  第17回日本遺伝子治療学会
- Place of Presentation
  福岡
- Year and Date
  2011-07-17
- Data Source
  KAKENHI-PROJECT-21390375
[Presentation] Liver-to-pancreas reprogramming膵切除後内分泌機能不全への応用2011
- Author(s)
  本山博章
- Organizer
  第66回日本消化器外科学会
- Place of Presentation
  名古屋市
- Year and Date
  2011-07-15
- Data Source
  KAKENHI-PROJECT-22591516
[Presentation] A Useful Non-viral Procedure to Induce Liver-to-pancreas Reprogramming to Complement Post-operative Pancreatic Endocrine Dysfunction2011
- Author(s)
  本山博章
- Organizer
  第17回日本遺伝子治療学会
- Place of Presentation
  福岡市
- Year and Date
  2011-07-17
- Data Source
  KAKENHI-PROJECT-21390375
[Presentation] Liver-to-pancreas reprogramming 膵切除後内分泌機能不全への応用2011
- Author(s)
  本山博章
- Organizer
  第66回日本消化器外科学会
- Place of Presentation
  名古屋
- Year and Date
  2011-07-15
- Data Source
  KAKENHI-PROJECT-22591516
[Presentation] Liver-to-pancreas reprogramming膵切除後内分泌機能不全への応用2011
- Author(s)
  本山博章
- Organizer
  第66回日本消化器外科学会
- Place of Presentation
  名古屋市
- Year and Date
  2011-07-15
- Data Source
  KAKENHI-PROJECT-21390375
[Presentation] An excellent non-viral procedure to induce liver-to-pancreas reprogramming to complement post-operative pancreatic endocrine dysfunction.2010
- Author(s)
  本山博章
- Organizer
  8th Catholic International Stem Cell Symposium
- Place of Presentation
  Seoul, Korea
- Year and Date
  2010-10-02
- Data Source
  KAKENHI-PROJECT-22591516
[Presentation] An excellent non-viral procedure to induce liver-to-pancreas reprogramming to complement post-operative pancreatic endocrine dysfunction.2010
- Author(s)
  Hiroaki Motoyama
- Organizer
  8th Catholic International Stem Cell Symposium
- Place of Presentation
  Catholic University of Korea
- Year and Date
  2010-10-02
- Data Source
  KAKENHI-PROJECT-20591604
[Presentation] An excellent non-viral procedure to induce liver-to-pancreas reprogramming to complement post-operative pancreatic endocrine dysfunction2010
- Author(s)
  本山博章
- Organizer
  8th Catholic International Stem Cell Symposium
- Place of Presentation
  Seoul, Korea
- Year and Date
  2010-10-02
- Data Source
  KAKENHI-PROJECT-21390375
[Presentation] An excellent non-viral procedure to induce liver-to-pancreas reprogramm ing to complement post-operative pancreatic endocrine dysfunction2010
- Author(s)
  本山博章
- Organizer
  8th Catholic International Stem Cell Symposium
- Place of Presentation
  Seoul, Korea
- Year and Date
  2010-10-02
- Data Source
  KAKENHI-PROJECT-22591516
[Presentation] An excellent non-viral procedure to induce liver-to-pancreas reprogramming to complement post-operative pancreatic endocrine dysfunction2010
- Author(s)
  Hiroaki Motoyama
- Organizer
  8th Catholic International Stem Cell Symposium
- Place of Presentation
  Korea
- Year and Date
  2010-10-02
- Data Source
  KAKENHI-PROJECT-20591604
[Presentation] 肝（由来）細胞を用いた膵内分泌細胞分化誘導
- Author(s)
  本山博章
- Organizer
  第114回日本外科学会定期学術集会
- Place of Presentation
  京都国際会議場
- Data Source
  KAKENHI-PROJECT-25462108

1. MIYAGAWA Shinichi (80229806)

# of Collaborated Projects: 7 results

# of Collaborated Products: 0 results
2. KOBAYASHI Akira (90334903)

# of Collaborated Projects: 5 results

# of Collaborated Products: 2 results
3. Shimizu Akira (00447773)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
4. MIWA Siroh (20293516)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
5. NAKATA Takenari (70377638)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
6. 宮川幸昭

# of Collaborated Projects: 0 results

# of Collaborated Products: 10 results

MOTOYAMA Hiroaki 本山 博章

Research Projects

Research Products

Co-Researchers

Analysis of promoting factor of liver regeneration in ALPPS

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Isolation of hepatic progenitor cells using specific surface molecules

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of a novel peptide-based therapy for cholangiocarcinoma

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

New modality for cell-replacement therapy using adult liver-derived progenitor cells for post-pancreatectomy diabetic patients.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The analysis of liver-to-pancreas reprogramming based on cellular interaction

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Isolation and characterization of portal branch ligation-stimulated liver-specific stem cells

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

New therapeutic approach with bone marrow cell for hereditary liver diseases

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Treatment with specific soluble factors promotes the functional maturation of transcription factor-mediated, pancreatic transdifferentiated cells2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Impaired degradation followed by enhanced recycling of epidermal growth factor receptor caused by hypo-phosphorylation of tyrosine 1045 in RBE cells.2012

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Isolation and characterization of portal branch ligation-stimulated Hmga2-positive bipotent hepatic progenitor cells2010

Author(s)

Journal Title

Data Source

[Journal Article] Isolation and characterization of portal branch ligation-stimulated Hmga2-positive bipotent hepatic progenitor cells2010

Author(s)

Journal Title

Data Source

[Journal Article] Isolation and characterization of portal branch ligation-stimulated Hmga2-positive bipotent hepatic progenitor cells.2010

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Isolation and characterization of portal branch ligation-stimulated Hmga2-positive bipotent hepatic progenitor cells.2010

Author(s)

Journal Title

Data Source

[Journal Article] Isolation and characterization of portal branch ligation-stimulated Hmga2-positive bipotent hepatic progenitor cells.2010

Author(s)

Journal Title

Data Source

[Journal Article] Isolation and characterization of portal branch ligation-stimulated Hmga2-positive bipotent hepatic progenitor cells2010

Author(s)

MOTOYAMA Hiroaki 本山博章