SHIMIZU AKIRA 清水明

… Alternative Names

Shimizu Akira 清水明

SHIMIZU Akira 清水明

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Researcher Number	00447773
Other IDs
Affiliation (Current)	2025: 信州大学, 学術研究院医学系(医学部附属病院), 准教授
Affiliation (based on the past Project Information) *help	2021 – 2025: 信州大学, 学術研究院医学系(医学部附属病院), 准教授 2015 – 2020: 信州大学, 学術研究院医学系(医学部附属病院), 講師 2014: 信州大学, 学術研究院医学系(医学部附属病院), 助教 2010: 信州大学, 医学部附属病院, 助教 2008: 信州大学, 医学部・附属病院, 助教(特定雇用) 2008: 信州大学, 医学部附属病院, 助教(特定雇用) 2007: 信州大学, 医学部附属病院, 助教
Review Section/Research Field	Principal Investigator Basic Section 55020:Digestive surgery-related / Digestive surgery Except Principal Investigator Digestive surgery / Basic Section 55020:Digestive surgery-related / Basic Section 55010:General surgery and pediatric surgery-related
Keywords	Principal Investigator 肝再生 / 胆汁鬱滞 / メタゲノム解析 / 肝切除 / 胆汁鬱滞モデル / 腸内細菌叢 / 外科 / NO誘導 / NOS / ALPPS … More Except Principal Investigator … More NK細胞受容体 / 消化器癌標的治療 / ペプチド / 肝細胞癌 / バイオパンニング法 / 細胞外DAMPs / がん微小環境 / 抗がん剤耐性 / ミトコンドリア / 膵癌 / 腫瘍免疫 / 臓器移植 / 免疫寛容 / Ly49 / CXCR5 / IRF2 / flowcytometry / CD8 / follicular helper T細胞 / 制御性T細胞 / Kupffer細胞 / 移植免疫 / 外科 / 臓器特異的幹細胞 / 肝組織内在性幹細胞 / 液性因子 / 分化転換 / 組織特異的幹細胞 / 化学療法 / オートファジー / 薬物療法 / 分子標的治療 / 抗癌剤治療 / 胆管癌 / 肝臓外科学 / バイオパニング法 Less

Development of anti-cancer drugs targeting mitochondrial dynamics for pancreatic cancer
- Principal Investigator
  
  窪田晃治
- Project Period (FY)
  2025 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Shinshu University
肝細胞癌局所におけるNK細胞受容体を介した細胞障害性T細胞機能制御機構の解明
- Principal Investigator
  
  野竹剛
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Shinshu University
Development of an innovative cell transplantation therapy using CD8 regulatory T cells to induce immune tolerance after organ transplantation
- Principal Investigator
  
  Notake Tsuyoshi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55010:General surgery and pediatric surgery-related
- Research Institution
  Shinshu University
Development of therapy for improving liver regeneration disorders associated with obstructive jaundice through intestinal microbiota metagenome analysisPrincipal Investigator
- Principal Investigator
  
  Shimizu Akira
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Shinshu University
Analysis of promoting factor of liver regeneration in ALPPSPrincipal Investigator
- Principal Investigator
  
  Shimizu Akira
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Shinshu University
Isolation of hepatic progenitor cells using specific surface molecules
- Principal Investigator
  
  Kobyashi Akira
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Shinshu University
Development of a novel peptide-based therapy for cholangiocarcinoma
- Principal Investigator
  
  MIYAGAWA Shin-ichi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Digestive surgery
- Research Institution
  Shinshu University
Development of anti-cancer drug modified by the peptide binding to cholangiocarcinoma.
- Principal Investigator
  
  ISHIZONE Satoshi
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Shinshu University
Development of anti-cancer drug modified by the peptide binding to Hepatocellular carcinoma
- Principal Investigator
  
  KOBAYASHI Akira
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Shinshu University

All 2023 2018 2017 2011 2010 2009 2008 2007

All Journal Article Presentation Patent

[Journal Article] 腸内細菌は閉塞性黄疸により影響されるのか2023
- Author(s)
  増尾仁志, 清水明, 生井楓, 副島雄二
- Journal Title
  
  胆と膵
  
  Volume: 44 Pages: 223-227
- Data Source
  KAKENHI-PROJECT-20K09101
[Journal Article] Treatment with specific soluble factors promotes the functional maturation of transcription factor-mediated, pancreatic transdifferentiated cells2018
- Author(s)
  Motoyama Hiroaki、Kobayashi Akira、Yokoyama Takahide、Shimizu Akira、Sakai Hiroshi、Notake Tsuyoshi、Fukushima Kentaro、Miyagawa Shin-ichi
- Journal Title
  
  PLOS ONE
  
  Volume: 13 Issue: 5 Pages: e0197175-e0197175
- DOI
  10.1371/journal.pone.0197175
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K10665, KAKENHI-PROJECT-15K10160
[Journal Article] CoP35, a cholangiocarcinoma-binding oligo-peptide, interacts with the clathrin heavy chain accompanied by GRP78.2011
- Author(s)
  Kitahara H, Masumoto J, Parker AL, Maruta F, Kubo N, Shimizu A, Akita N, Miwa S, Kobayashi N, Nakayama J, Miyagawa S.
- Journal Title
  
  Mol Cancer Res. in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591588
[Journal Article] 【腫瘍占居部位からみた肝切除の手技と工夫】右肝静脈合併肝切除における後区域静脈還流温存のための工夫2009
- Author(s)
  清水明, 小林聡, 内川裕司, 三輪史郎, 宮川眞一
- Journal Title
  
  消化器外科 32巻2号
  
  Pages: 173-181
- Data Source
  KAKENHI-PROJECT-19591581
[Journal Article] 【腫瘍占居部位からみた肝切除の手技と工夫】右肝静脈合併肝切除における後区域静脈還流温存のための工夫2009
- Author(s)
  清水明, 小林聡, 宮川償一, 他
- Journal Title
  
  消化器外科 32
  
  Pages: 173-181
- Data Source
  KAKENHI-PROJECT-19591581
[Journal Article] 【再発肝癌診療におけるコンセンサスと個別化】再発時期の観点からみた再肝切除の成績2008
- Author(s)
  小林聡, 宮川眞一, 三輪史郎, 横山隆秀, 中田岳成, 三原基弘, 宮川雄輔, 大野康成, 清水明, 添田純平, 鈴木史恭, 秋田眞吾, 古澤徳彦, 増田雄一, 荒居琢磨
- Journal Title
  
  消化器科 47巻1号
  
  Pages: 81-84
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591581
[Journal Article] Identification of oligopeptide binding to colon cancer cells separated from patients using laser capture microdissection.2008
- Author(s)
  久保直樹, 清水明, 宮川眞一, 他
- Journal Title
  
  J Drug Target 16
  
  Pages: 396-404
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591581
[Journal Article] Identification of oligopeptide binding to colon cancer cells separated from patients using laser capture microdissection2008
- Author(s)
  Kubo N, Akita N, Shimizu A, Kitahara H, Parker AL, Miyagawa S
- Journal Title
  
  J Drug Target 16(5)
  
  Pages: 396-404
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591581
[Journal Article] 【再発肝癌診療におけるコンセンサスと個別化】再発時期の観点からみた再肝切除の成績2008
- Author(s)
  小林聡, 宮川波一, 清水明, 他
- Journal Title
  
  消化器科 47
  
  Pages: 81-84
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591581
[Journal Article] A clinical study of docetaxel with or without 5'DFUR as a second-line chemotherapy for advanced gastric cancer2007
- Author(s)
  Maruta F, Ishizone S, Hiraguri M, Fujimori Y, Shimizu F, Kumeda S, Miyagawa S
- Journal Title
  
  Med Oncol 24(1)
  
  Pages: 71-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591581
[Patent] クリアランス結合性ペプチド誘導体2009
- Inventor(s)
  宮川眞一、清水明、北原弘恵、増本純也
- Industrial Property Rights Holder
  信州大学
- Industrial Property Number
  2009-250552
- Filing Date
  2009-10-30
- Data Source
  KAKENHI-PROJECT-20591588
[Presentation] ラットALPPSモデルの肝再生過程における虚血肝領域と炎症性サイトカインの影響2017
- Author(s)
  清水明
- Organizer
  第117回日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-17K10664
[Presentation] ラットALPPSモデルの肝再生過程における再生促進因子の検討2017
- Author(s)
  清水明
- Organizer
  第72回日本消化器外科学会総会
- Data Source
  KAKENHI-PROJECT-17K10664
[Presentation] バイオパンニング法による胆管癌特異的ペプチドの同定2010
- Author(s)
  北原弘恵、増本純也、清水明、久保直樹、秋田倫幸、三輪史郎、中山淳、宮川眞一
- Organizer
  第52回日本消化器病学会総会
- Place of Presentation
  横浜市
- Year and Date
  2010-10-13
- Data Source
  KAKENHI-PROJECT-20591588
[Presentation] バイオパンニング法による胆管癌特異的ペプチドの同定2010
- Author(s)
  北原弘恵、増本純也、久保直樹、清水明、秋田倫幸、三輪史郎、中山淳、宮川眞一
- Organizer
  第110回日本外科学会総会
- Place of Presentation
  名古屋市
- Year and Date
  2010-04-08
- Data Source
  KAKENHI-PROJECT-20591588
[Presentation] バイオパンニング法による胆管癌特異的ペプチドの同定2009
- Author(s)
  北原弘恵、久保直樹、清水明、秋田倫幸、三輪史郎、宮川眞一
- Organizer
  第108回日本外科学会総会
- Place of Presentation
  長崎市
- Year and Date
  2009-05-15
- Data Source
  KAKENHI-PROJECT-20591588
[Presentation] バイオパンニング法による胆管癌特異的結合ペプチドの同定2008
- Author(s)
  北原弘恵, 丸田福門, 久保直樹, 清水明, 秋田倫幸, 三輪史郎, 宮川眞一
- Organizer
  第67回日本癌学会学術総会
- Place of Presentation
  名古屋・名古屋国際会議場
- Data Source
  KAKENHI-PROJECT-19591581
[Presentation] 肝門部胆管癌治癒切除後の再発部位と再発危険因子に関する検討2008
- Author(s)
  小林聡, 宮川屏一, 清水明, 他
- Organizer
  第20回日本肝胆膠外科学会・学術集会
- Place of Presentation
  山形・山形国際ホテル
- Year and Date
  2008-05-29
- Data Source
  KAKENHI-PROJECT-19591581
[Presentation] 再発肝細胞癌に対する再肝切除の適応に関する検討2008
- Author(s)
  小林聡, 宮川眞一, 三輪史郎, 横山隆秀, 中田岳成, 三原基弘, 大野康成, 清水明, 鈴木史恭, 古澤徳彦
- Organizer
  第63回日本消化器外科学会総会
- Place of Presentation
  札幌・ロイトン札幌
- Year and Date
  2008-07-18
- Data Source
  KAKENHI-PROJECT-19591581
[Presentation] 肝腫瘍占拠部位別の肝切除術の工夫と理論. 右肝静脈合併肝切除における後区域静脈還流温存のための工夫2008
- Author(s)
  清水明, 小林聡, 古澤徳彦, 鈴木史恭, 大野康成, 中田岳成, 三原基弘, 横山隆秀, 三輪史郎, 宮川眞一
- Organizer
  第63回日本消化器外科学会総会
- Place of Presentation
  札幌・北海道厚生年金会館
- Year and Date
  2008-07-18
- Data Source
  KAKENHI-PROJECT-19591581
[Presentation] 肝硬変合併肝細胞癌に対する系統的亜区域切除術の実際2008
- Author(s)
  小林聡, 宮川眞一, 三輪史郎, 横山隆秀, 中田岳成, 三原基弘, 大野康成, 清水明, 添田純平, 鈴木史恭, 古沢徳彦,北川敬之, 野竹剛, 横井謙太
- Organizer
  第108回日本外科学会定期学術集会
- Place of Presentation
  長崎・NCC&スタジオ
- Year and Date
  2008-05-17
- Data Source
  KAKENHI-PROJECT-19591581
[Presentation] 肝門部胆管癌治癒切除後の再発部位と再発危険因子に関する検討2008
- Author(s)
  小林聡, 宮川眞一, 三輪史郎, 横山隆秀, 中田岳成, 三原基弘, 大野康成, 清水明, 添田純平, 鈴木史恭, 秋田眞吾, 古沢徳彦, 増田雄一, 北川敬之, 野竹剛, 横井謙太
- Organizer
  第20回日本肝胆膵外科学会・学術集会
- Place of Presentation
  山形・山形国際ホテル
- Year and Date
  2008-05-29
- Data Source
  KAKENHI-PROJECT-19591581
[Presentation] 肝腫瘍占拠部位別の肝切除術の工夫と理論右肝静脈合併肝切除における後区域静脈還流温存のための工夫2008
- Author(s)
  清水明, 小林聡, 宮川眞一, 他
- Organizer
  第63回日本消化器外科学会総会
- Place of Presentation
  札幌・北海道厚生年金会館
- Year and Date
  2008-07-18
- Data Source
  KAKENHI-PROJECT-19591581
[Presentation] バイオパンニング法による月旦管癌特異的ペプチドの同定2008
- Author(s)
  北原弘恵、丸田福門、久保直樹、清水明、秋田倫幸、三輪史郎、宮川眞一
- Organizer
  第46回日本癌治療学会総会
- Place of Presentation
  名古屋市
- Year and Date
  2008-10-30
- Data Source
  KAKENHI-PROJECT-20591588
[Presentation] 進行胆嚢癌に対する至適術式の検討2008
- Author(s)
  清水明, 小林聡, 中田岳成, 竹内大輔, 野竹剛, 北川敬之, 横井謙太, 古澤徳彦, 秋田眞吾, 鈴木史恭, 添田純平, 大野康成, 三原基弘, 横山隆秀, 三輪史郎, 宮川眞一
- Organizer
  第108回日本外科学会定期学術集会
- Place of Presentation
  長崎・長崎新聞文化ホール
- Year and Date
  2008-05-15
- Data Source
  KAKENHI-PROJECT-19591581
[Presentation] 進行胆嚢癌における予後因子と合併切除に関する検討2008
- Author(s)
  清水明, 小林聡, 中田岳成, 横井謙太, 野竹剛, 北川敬之, 秋田眞吾, 古澤徳彦, 鈴木史恭, 添田純平, 大野康成, 三原基弘, 横山隆秀, 三輪史郎, 宮川眞一
- Organizer
  第20回日本肝胆膵外科学会・学術集会
- Place of Presentation
  山形・山形国際ホテル
- Year and Date
  2008-05-29
- Data Source
  KAKENHI-PROJECT-19591581
[Presentation] バイオパンニング法を用いた肝細胞癌特異的結合ペプチドの同定2007
- Author(s)
  清水明, 丸田福門, 秋田倫幸, 三輪史郎, 宮川眞一
- Organizer
  第107回日本外科学会定期学術集会
- Place of Presentation
  日大阪・大阪国際会議場
- Data Source
  KAKENHI-PROJECT-19591581
[Presentation] 消化器癌の発生機序から見た治療戦略肝胆膵癌. 肝細胞癌標的治療へのバイオパンニング法の応用2007
- Author(s)
  清水明, 丸田福門, 秋田倫幸, 添田純平, 小川真一郎, 三原基弘, 三輪史郎, 宮川眞一
- Organizer
  第62回日本消化器外科学会定期学術総会
- Place of Presentation
  新宿・京王プラザホテル
- Year and Date
  2007-07-19
- Data Source
  KAKENHI-PROJECT-19591581
[Presentation] 肝細胞癌標的治療へのバイオパンニング法の応用2007
- Author(s)
  清水明
- Organizer
  第62回日本消化器外科学会定期学術総会
- Place of Presentation
  東京京王プラザ
- Year and Date
  2007-07-19
- Data Source
  KAKENHI-PROJECT-19591581
[Presentation] 肝異時性多発癌に対する治療戦略2007
- Author(s)
  小林聡, 宮川眞一, 三輪史郎, 中田岳成, 三原基弘, 宮川雄輔, 小川真一郎, 清水明, 添田純平, 名取恵子
- Organizer
  第62回日本消化器外科学会定期学術総会
- Place of Presentation
  新宿・京王プラザホテル
- Year and Date
  2007-07-18
- Data Source
  KAKENHI-PROJECT-19591581
[Presentation] バイオパンニング法を用いた肝細胞癌特異的結合ペプチドの同定2007
- Author(s)
  清水明
- Organizer
  第107回日本外科学会定期学術集会
- Place of Presentation
  大阪大阪国際会議場リーガロイヤルホテル
- Year and Date
  2007-04-11
- Data Source
  KAKENHI-PROJECT-19591581

1. MIYAGAWA Shinichi (80229806)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
2. KOBAYASHI Akira (90334903)

# of Collaborated Projects: 4 results

# of Collaborated Products: 14 results
3. Notake Tsuyoshi (40645511)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
4. 副島雄二 (30325526)

# of Collaborated Projects: 4 results

# of Collaborated Products: 1 results
5. 本山博章 (20569587)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
6. 窪田晃治 (10598220)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
7. ISHIZONE Satoshi (90419341)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. KOMATSU Daisuke (50507481)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. MURANAKA Futoshi (80507492)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. KITAHARA Hiroe (20569321)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
11. 安川紘矢 (30868071)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 増田雄一 (60467149)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 山条秀樹 (50391967)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 北川敬之 (70507491)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 吉澤隆裕 (90935983)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 宮川幸昭

# of Collaborated Projects: 0 results

# of Collaborated Products: 25 results

SHIMIZU AKIRA 清水 明

Shimizu Akira 清水 明

SHIMIZU Akira 清水 明

Research Projects

Research Products

Co-Researchers

Development of anti-cancer drugs targeting mitochondrial dynamics for pancreatic cancer

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

肝細胞癌局所におけるNK細胞受容体を介した細胞障害性T細胞機能制御機構の解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of an innovative cell transplantation therapy using CD8 regulatory T cells to induce immune tolerance after organ transplantation

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Development of therapy for improving liver regeneration disorders associated with obstructive jaundice through intestinal microbiota metagenome analysisPrincipal Investigator

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Analysis of promoting factor of liver regeneration in ALPPSPrincipal Investigator

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Isolation of hepatic progenitor cells using specific surface molecules

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Development of a novel peptide-based therapy for cholangiocarcinoma

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Development of anti-cancer drug modified by the peptide binding to cholangiocarcinoma.

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Development of anti-cancer drug modified by the peptide binding to Hepatocellular carcinoma

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[Journal Article] 腸内細菌は閉塞性黄疸により影響されるのか2023

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[Journal Article] Treatment with specific soluble factors promotes the functional maturation of transcription factor-mediated, pancreatic transdifferentiated cells2018

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[Journal Article] CoP35, a cholangiocarcinoma-binding oligo-peptide, interacts with the clathrin heavy chain accompanied by GRP78.2011

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[Journal Article] 【腫瘍占居部位からみた肝切除の手技と工夫】右肝静脈合併肝切除における後区域静脈還流温存のための工夫2009

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[Journal Article] 【腫瘍占居部位からみた肝切除の手技と工夫】右肝静脈合併肝切除における後区域静脈還流温存のための工夫2009

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SHIMIZU AKIRA 清水明

Shimizu Akira 清水明

SHIMIZU Akira 清水明