Takeuchi Kou 竹内恒

… Alternative Names

TAKEUCHI Koh 竹内恒

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Researcher Number	20581284
Other IDs	https://orcid.org/0000-0002-6227-4627
Affiliation (Current)	2025: 東京大学, 大学院薬学系研究科(薬学部), 教授
Affiliation (based on the past Project Information) *help	2021 – 2023: 東京大学, 大学院薬学系研究科(薬学部), 教授 2019 – 2022: 国立研究開発法人産業技術総合研究所, 生命工学領域, 研究グループ長 2017 – 2019: 国立研究開発法人産業技術総合研究所, 生命工学領域, 研究チーム長 2015 – 2016: 国立研究開発法人産業技術総合研究所, 創薬分子プロファイリング研究センター, 主任研究員 2014: 産業技術総合研究所, 創薬分子プロファイリング研究センター, 主任研究員 … More 2012 – 2014: 独立行政法人産業技術総合研究所, 創薬分子プロファイリング研究センター, 主任研究員 2013: 独立行政法人産業技術総合研究所, その他部局等, 研究員 2012: 産業技術総合研究所, 創薬分子プロファイリング研究センター, 研究員 2011: National Institute of Advanced Industrial Science and Technology, 研究員 2010 – 2011: 独立行政法人産業技術総合研究所, バイオメディシナル情報研究センター, 研究員 Less
Review Section/Research Field	Principal Investigator Medium-sized Section 47:Pharmaceutical sciences and related fields / Physical pharmacy / Science and Engineering / Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related / Biological Sciences Except Principal Investigator Structural biochemistry / Basic Section 43030:Functional biochemistry-related / Basic Section 57030:Conservative dentistry-related / Basic Section 43020:Structural biochemistry-related / Biological Sciences
Keywords	Principal Investigator NMR / 構造生物学 / 動的構造 / 創薬基盤技術 / 立体構造解析 / 薬物 / 動的相互作用 / タンパク質 / 創薬 / 多剤耐性 … More / 核磁気共鳴 / 細胞内創薬 / 細胞内移行速度 / in cell / クリプトサイト / 創薬作用点 / 薬剤設計 / 運動性 / 立体構造 / 相互作用 / 薬剤 / 分子夾雑 / 膜透過活性 / モダリティ / 膜透過 / 中分子 / バイオ医薬 / 測定技術開発 / 非侵襲的 / 非破壊的 / 製剤条件 / バイオ医薬品 / 高次構造解析 / 創薬科学 / 高分子バイオ医薬 / 動的立体構造解析 / 溶液NMR法 / X線結晶構造解析 / 複合体 / キナーゼ / タンパク質発現 / 膜タンパク質 / ^<13>C-^<12>C交互標識 / ピルビン酸 / 連鎖帰属 / 安定同立体標識 / 核磁気共鳴法 … More Except Principal Investigator NMR / 膜タンパク質 / 酵母 / 硫黄転移酵素 / 硫黄代謝 / 硫黄修飾塩基 / 無酸素実験 / 活性化硫黄 / 硫黄 / 修飾塩基 / 転写後修飾 / tRNA / 根尖性歯周炎 / 超高齢社会 / テレイン / TNF-alpha / 破骨細胞 / PKC / RANKL / TNF-alph / IL-6 / 歯周病 / terrein / 酵素 / 脂質 / 界面活性剤 / 動的立体構造 / GPCR / 動的構造 / 動的構造平衡 / 多剤耐性トランスポーター / イオンチャネル / Gタンパク質共役型受容体 / 核磁気共鳴法 Less

in cell structure-guided drug development by NMRPrincipal Investigator
- Principal Investigator
  
  竹内恒
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Pioneering)
- Review Section
  
  Medium-sized Section 47:Pharmaceutical sciences and related fields
- Research Institution
  The University of Tokyo
Molecular basis for biosynthetic and degradation systems for tRNA sulfur-modified bases
- Principal Investigator
  
  Shigi Naoki
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 43030:Functional biochemistry-related
- Research Institution
  National Institute of Advanced Industrial Science and Technology
Development of basic strategy to structurally evaluate the membrane permeation activity of middle-size moleculesPrincipal Investigator
- Principal Investigator
  
  Takeuchi Koh
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 47:Pharmaceutical sciences and related fields
- Research Institution
  The University of Tokyo
  National Institute of Advanced Industrial Science and Technology
分子夾雑環境下におけるタンパク質と薬物の動的相互作用解析Principal Investigator
- Principal Investigator
  
  竹内恒
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Science and Engineering
- Research Institution
  The University of Tokyo
  National Institute of Advanced Industrial Science and Technology
Structure and dynamics based drug development to obtain highly active compoundsPrincipal Investigator
- Principal Investigator
  
  Takeuchi Koh
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related
- Research Institution
  The University of Tokyo
  National Institute of Advanced Industrial Science and Technology
Identification and Functional Analysis of the Target Molecule of Terrein, a Small Molecule Compound for Application in the Super-Aging Society
- Principal Investigator
  
  Omori Kazuhiro
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57030:Conservative dentistry-related
- Research Institution
  Okayama University
NMR method to obtain structural fingerprints of an intact monoclonal antibody acquired under formulated storage conditionsPrincipal Investigator
- Principal Investigator
  
  Takeuchi Koh
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 47:Pharmaceutical sciences and related fields
- Research Institution
  National Institute of Advanced Industrial Science and Technology
Analysis of functional dynamics of membrane proteins in different membrane environments
- Principal Investigator
  
  Takahashi Hideo
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 43020:Structural biochemistry-related
- Research Institution
  Yokohama City University
In situ functional analyses of membrane proteins by NMR
- Principal Investigator
  
  Shimada Ichio
- Project Period (FY)
  2017 – 2021
- Research Category
  
  Grant-in-Aid for Specially Promoted Research
- Review Section
  
  Biological Sciences
- Research Institution
  Institute of Physical and Chemical Research
  The University of Tokyo
NMR approach for the functional structural analyses of human membrane proteins
- Principal Investigator
  
  Takahashi Hideo
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Structural biochemistry
- Research Institution
  Yokohama City University
多剤耐性転写制御因子の動的薬剤認識と機能発現のＮＭＲ解析Principal Investigator
- Principal Investigator
  
  竹内恒
- Project Period (FY)
  2014
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Physical pharmacy
- Research Institution
  National Institute of Advanced Industrial Science and Technology
X線結晶構造解析・核磁気共鳴法の融合によるキナーゼ複合体の動的立体構造解析Principal Investigator
- Principal Investigator
  
  竹内恒
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  National Institute of Advanced Industrial Science and Technology
Fundamental research for NMR structural analysis of human membrane proteins
- Principal Investigator
  
  TAKAHASHI Hideo
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Structural biochemistry
- Research Institution
  Yokohama City University
原核生物多剤耐性トランスポーターの構造揺らぎと薬剤排出活性のＮＭＲ解析Principal Investigator
- Principal Investigator
  
  竹内恒
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Science and Engineering
- Research Institution
  National Institute of Advanced Industrial Science and Technology
Structure determination and elucidation of transport mechanism of mitochondrial inner membrane transporterPrincipal Investigator
- Principal Investigator
  
  TAKEUCHI Koh
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  National Institute of Advanced Industrial Science and Technology
新規安定同位体ラベル法を用いた高分子量創薬ターゲット蛋白質の構造機能解析法の開発Principal Investigator
- Principal Investigator
  
  竹内恒
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Physical pharmacy
- Research Institution
  National Institute of Advanced Industrial Science and Technology

[Book] 「揺らぎ・ダイナミクスと生体機能」第19章・第5項~第9項2013
- Author(s)
  竹内恒、徳永裕二、嶋田一夫
- Total Pages
  350
- Publisher
  同人バイオサイエンス
- Data Source
  KAKENHI-PUBLICLY-25121743
[Book] Royal Society of Chemistry,Recent Developments in Biomolecular NMR2012
- Author(s)
  Takeuchi K, Gal M, Shimada I, and Wagner G 他
- Total Pages
  364
- Data Source
  KAKENHI-PROJECT-23790064
[Journal Article] Molecular basis promoting centriole triplet microtubule assembly2024
- Author(s)
  Takeda Yutaka、Chinen Takumi、Honda Shunnosuke、Takatori Sho、Okuda Shotaro、Yamamoto Shohei、Fukuyama Masamitsu、Takeuchi Koh、Tomita Taisuke、Hata Shoji、Kitagawa Daiju
- Journal Title
  
  Nature Communications
  
  Volume: 15 Issue: 1 Pages: 2216-2216
- DOI
  10.1038/s41467-024-46454-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K18374, KAKENHI-PROJECT-22K19305, KAKENHI-PROJECT-22KJ0636, KAKENHI-PROJECT-23K23892, KAKENHI-PROJECT-22H04925, KAKENHI-PROJECT-23H00394
[Journal Article] Nonthermal acceleration of protein hydration by sub-terahertz irradiation2023
- Author(s)
  Sugiyama Jun-ichi、Tokunaga Yuji、Hishida Mafumi、Tanaka Masahito、Takeuchi Koh、Satoh Daisuke、Imashimizu Masahiko
- Journal Title
  
  Nature Communications
  
  Volume: 14 Issue: 1 Pages: 2825-2825
- DOI
  10.1038/s41467-023-38462-0
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K18374, KAKENHI-PLANNED-19H05717, KAKENHI-PUBLICLY-22H04566, KAKENHI-PROJECT-23K27310, KAKENHI-PROJECT-20H03298
[Journal Article] Functional molecular evolution of a <scp>GTP</scp> sensing kinase: <scp>PI5P4Kβ</scp>2023
- Author(s)
  Takeuchi Koh、Senda Miki、Ikeda Yoshiki、Okuwaki Koji、Fukuzawa Kaori、Nakagawa So、Sasaki Mika、Sasaki Atsuo T.、Senda Toshiya
- Journal Title
  
  The FEBS Journal
  
  Volume: 290 Issue: 18 Pages: 4419-4428
- DOI
  10.1111/febs.16763
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03378, KAKENHI-PROJECT-20H03165
[Journal Article] The oxidative folding of nascent polypeptides provides electrons for reductive reactions in the ER2023
- Author(s)
  Uegaki Kaiku、Tokunaga Yuji、Inoue Michio、Takashima Seiji、Inaba Kenji、Takeuchi Koh、Ushioda Ryo、Nagata Kazuhiro
- Journal Title
  
  Cell Reports
  
  Volume: 42 Issue: 7 Pages: 112742-112742
- DOI
  10.1016/j.celrep.2023.112742
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K18374, KAKENHI-PROJECT-21H02914, KAKENHI-PROJECT-23K23885, KAKENHI-PLANNED-21H05253, KAKENHI-PLANNED-21H05268, KAKENHI-PUBLICLY-22H05558, KAKENHI-PROJECT-21H04758, KAKENHI-PROJECT-23K27310
[Journal Article] Multimodal action of KRP203 on phosphoinositide kinases in vitro and in cells2023
- Author(s)
  Ikeda Yoshiki、Davis Mindy I.、Sumita Kazutaka、Zheng Yuxiang、Kofuji Satoshi、Sasaki Mika、Hirota Yoshihisa、Pragani Rajan、Shen Min、Boxer Matthew B.、Takeuchi Koh、Senda Toshiya、Simeonov Anton、Sasaki Atsuo T.
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 679 Pages: 116-121
- DOI
  10.1016/j.bbrc.2023.08.050
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K18374, KAKENHI-PROJECT-21K11709, KAKENHI-PROJECT-20H03165
[Journal Article] Absence of ULK1 decreases AMPK activity in the kidney, leading to chronic kidney disease progression2023
- Author(s)
  Tomoki Yanagi, Hiroaki Kikuchi, Koichiro Susa, Naohiro Takahashi, Naohiro Takahashi, Hiroki Bamba, Takefumi Suzuki, Yuta Nakano, Tamami Fujiki, Yutaro Mori, Fumiaki Ando, Shintaro Mandai, Takayasu Mori, Koh Takeuchi, Shinya Honda, Satoru Torii, Shigeomi Shimizu, Tatemitsu Rai, Shinichi Uchida, Eisei Sohara
- Journal Title
  
  Genes to Cells
  
  Volume: 28 Issue: 1 Pages: 5-14
- DOI
  10.1111/gtc.12989
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08223, KAKENHI-PROJECT-21K08249, KAKENHI-PROJECT-22K07345, KAKENHI-PROJECT-22K19518, KAKENHI-PROJECT-20H00467, KAKENHI-PROJECT-21K20710, KAKENHI-WRAPUP-22H04899, KAKENHI-PROJECT-23K19610, KAKENHI-PUBLICLY-22H04639, KAKENHI-PROJECT-20H03378
[Journal Article] Amide-to-ester substitution as a stable alternative to N-methylation for increasing membrane permeability in cyclic peptides.2023
- Author(s)
  Hosono Y, Uchida S, Shinkai M, Townsend CE, Kelly CN, Naylor MR, Lee HW, Kanamitsu K, Ishii M, Ueki R, Ueda T, Takeuchi K, Sugita M, Akiyama Y, Lokey SR, Morimoto J, Sando S.
- Journal Title
  
  Nat. Commun.
  
  Volume: 14 Issue: 1 Pages: 1416-1416
- DOI
  10.1038/s41467-023-36978-z
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-21H05509, KAKENHI-PROJECT-20H03375, KAKENHI-PROJECT-23K24939, KAKENHI-PROJECT-22K18374
[Journal Article] Residue-based program of a β-peptoid twisted strand shape via a cyclopentane constraint2022
- Author(s)
  Kim J, Kobayashi H, Yokomine M, Shiratori Y, Ueda T, Takeuchi K, Umezawa K, Kuroda D, Tsumoto K, Morimoto J, Sando S.
- Journal Title
  
  Org. Biomol. Chem.
  
  Volume: 20 Issue: 35 Pages: 6994-7000
- DOI
  10.1039/d2ob01300b
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-21H05509, KAKENHI-PROJECT-20H02531, KAKENHI-PROJECT-20H03375, KAKENHI-PROJECT-20H03378
[Journal Article] Oligo(N‐methylalanine) as a Peptide‐Based Molecular Scaffold with a Minimal Structure and High Density of Functionalizable Sites2022
- Author(s)
  Yokomine Marin、Morimoto Jumpei、Fukuda Yasuhiro、Shiratori Yota、Kuroda Daisuke、Ueda Takumi、Takeuchi Koh、Tsumoto Kouhei、Sando Shinsuke
- Journal Title
  
  Angewandte Chemie International Edition
  
  Volume: 61 Issue: 14 Pages: 6994-7000
- DOI
  10.1002/anie.202200119
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K21494, KAKENHI-PROJECT-19H03522, KAKENHI-PUBLICLY-21H05509, KAKENHI-PROJECT-20H03375, KAKENHI-PROJECT-20H03378, KAKENHI-PROJECT-19H04202
[Journal Article] <sup>15</sup>N-Detected TROSY NMR experiments to study large disordered proteins in high-field magnets2022
- Author(s)
  Dubey Abhinav、Viennet Thibault、Chhabra Sandeep、Takeuchi Koh、Seo Hee-Chan、Bermel Wolfgang、Frueh Dominique P.、Arthanari Haribabu
- Journal Title
  
  Chemical Communications
  
  Volume: 58 Issue: 68 Pages: 9512-9515
- DOI
  10.1039/d2cc02005j
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03378
[Journal Article] S. Helix-forming aliphatic homo-δ-peptide foldamers based on the conformational restriction effects of cyclopropane.2022
- Author(s)
  89.Nagata, M.; Watanabe, M.; Doi, R.; Uemura, M.; Ochiai, N.; Ichinose, W.; Fujiwara, K.; Kameda, T.; Sato, Y.; Takeuchi, K.; Shuto,
- Journal Title
  
  Org. Biomol. Chem.
  
  Volume: - Issue: 5 Pages: 970-980
- DOI
  10.1039/d2ob01715f
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H01014, KAKENHI-PROJECT-22K06494, KAKENHI-PROJECT-20H03378
[Journal Article] The GTP responsiveness of PI5P4Kβ evolved from a compromised trade-off between activity and specificity2022
- Author(s)
  Takeuchi Koh、Ikeda Yoshiki、Senda Miki、Harada Ayaka、Okuwaki Koji、Fukuzawa Kaori、Nakagawa So、Yu Hong Yang、Nagase Lisa、Imai Misaki、Sasaki Mika、Lo Yu-Hua、Ito Doshun、Osaka Natsuki、Fujii Yuki、Sasaki Atsuo T.、Senda Toshiya
- Journal Title
  
  Structure
  
  Volume: 30 Issue: 6 Pages: 886-899.e4
- DOI
  10.1016/j.str.2022.04.004
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03165, KAKENHI-PROJECT-20H03378, KAKENHI-PROJECT-22KJ2661
[Journal Article] Role of the orphan transporter SLC35E1 in the nuclear egress of herpes simplex virus 12022
- Author(s)
  Fumio Maeda, Akihisa Kato, Kosuke Takeshima, Misato Shibazaki, Ryota Sato, Takuma Shibata, Kensuke Miyake, Hiroko Kozuka-Hata, Masaaki Oyama, Eigo Shimizu, Seiya Imoto, Satoru Miyano, Shungo Adachi, Tohru Natsume, Koh Takeuchi, Yuhei Maruzuru, Naoto Koyanagi, Jun Arii, Yasushi Kawaguchi
- Journal Title
  
  Journal of Virology
  
  Volume: - Issue: 10 Pages: 10-10
- DOI
  10.1128/jvi.00306-22
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K22524, KAKENHI-PROJECT-20K07511, KAKENHI-PROJECT-21K19370, KAKENHI-PROJECT-21K19498, KAKENHI-PROJECT-22K15468, KAKENHI-PLANNED-21H05280, KAKENHI-PLANNED-22H05184, KAKENHI-PUBLICLY-22H05584, KAKENHI-PROJECT-21H04800, KAKENHI-PROJECT-20H03496, KAKENHI-PROJECT-21K15464, KAKENHI-PROJECT-20H05692, KAKENHI-PROJECT-20H03492, KAKENHI-PUBLICLY-21H00338, KAKENHI-PUBLICLY-21H00417, KAKENHI-WRAPUP-22H04899, KAKENHI-PROJECT-20H03378
[Journal Article] NMR法を用いた中分子環状ペプチドの立体構造解析と細胞内移行活性の理2021
- Author(s)
  竹内恒、嶋田一夫
- Journal Title
  
  Pharm Stage
  
  Volume: 21 Pages: 8-8
- Data Source
  KAKENHI-PROJECT-17H06097
[Journal Article] Conformational Plasticity of Cyclic Ras‐Inhibitor Peptides Defines Cell Permeabilization Activity2021
- Author(s)
  Takeuchi Koh、Misaki Imai、Tokunaga Yuji、Fujisaki Miwa、Kamoshida Hajime、Takizawa Takeshi、Hanzawa Hiroyuki、Shimada Ichio
- Journal Title
  
  Angewandte Chemie International Edition
  
  Volume: 60 Issue: 12 Pages: 6567-6572
- DOI
  10.1002/anie.202016647
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K21494, KAKENHI-PROJECT-17H06097
[Journal Article] Nonthermal excitation effects mediated by subterahertz radiation on hydrogen exchange in ubiquitin2021
- Author(s)
  Tokunaga Yuji、Tanaka Masahito、Iida Hitoshi、Kinoshita Moto、Tojima Yuya、Takeuchi Koh、Imashimizu Masahiko
- Journal Title
  
  Biophysical Journal
  
  Volume: 120 Issue: 12 Pages: 1-8
- DOI
  10.1016/j.bpj.2021.04.013
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K18731, KAKENHI-PROJECT-18H02393, KAKENHI-PROJECT-20H03298
[Journal Article] Function-Related Dynamics in Multi-Spanning Helical Membrane Proteins Revealed by Solution NMR2021
- Author(s)
  Takeuchi Koh、Kofuku Yutaka、Imai Shunsuke、Ueda Takumi、Tokunaga Yuji、Toyama Yuki、Shiraishi Yutaro、Shimada Ichio
- Journal Title
  
  Membranes
  
  Volume: 11 Issue: 8 Pages: 604-604
- DOI
  10.3390/membranes11080604
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K21494, KAKENHI-PUBLICLY-20H04722, KAKENHI-PROJECT-18H02393, KAKENHI-PROJECT-21H02619, KAKENHI-PROJECT-20K21473, KAKENHI-PROJECT-17H06097, KAKENHI-PUBLICLY-21H05509, KAKENHI-PROJECT-20H03375, KAKENHI-PROJECT-20H03378, KAKENHI-PROJECT-23K21289
[Journal Article] Flexibility and cell permeability of cyclic Ras-inhibitor peptides revealed by coupled Nose Hoover equation2021
- Author(s)
  Kei Moritsugu, Koh Takeuchi, Narutoshi Kamiya, Junichi Higo, Isao Yasumatsu, Yoshifumi Fukunishi and Ikuo Fukuda
- Journal Title
  
  Journal of Chemical Information and Modeling
  
  Volume: 61 Issue: 4 Pages: 1921-1930
- DOI
  10.1021/acs.jcim.0c01427
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K03883, KAKENHI-PROJECT-20K11854, KAKENHI-PROJECT-20K21494, KAKENHI-PROJECT-17K05143, KAKENHI-PROJECT-18H02393, KAKENHI-PROJECT-20H03229
[Journal Article] NMRを用いた動的構造解析への取り組みと創薬への展開2021
- Author(s)
  竹内恒
- Journal Title
  
  日本核磁気共鳴学会機関紙
  
  Volume: 11 Pages: 27-34
- Data Source
  KAKENHI-PROJECT-17H06097
[Journal Article] Role of NMR in High Ordered Structure Characterization of Monoclonal Antibodies2020
- Author(s)
  Tokunaga Yuji、Takeuchi Koh
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 22 Issue: 1 Pages: 46-46
- DOI
  10.3390/ijms22010046
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-20H04722, KAKENHI-PROJECT-20H03378
[Journal Article] Targeting the cryptic sites: NMR-based strategy to improve protein druggability by controlling the conformational equilibrium2020
- Author(s)
  Mizukoshi Yumiko、Takeuchi Koh、Tokunaga Yuji、Matsuo Hitomi、Imai Misaki、Fujisaki Miwa、Kamoshida Hajime、Takizawa Takeshi、Hanzawa Hiroyuki、Shimada Ichio
- Journal Title
  
  Science Advances
  
  Volume: 6 Issue: 40
- DOI
  10.1126/sciadv.abd0480
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-20H04722, KAKENHI-PROJECT-18H02393, KAKENHI-PROJECT-20H03378, KAKENHI-PROJECT-17H06097
[Journal Article] The role of NMR in leveraging dynamics and entropy in drug design2020
- Author(s)
  Dubey Abhinav、Takeuchi Koh、Reibarkh Mikhail、Arthanari Haribabu
- Journal Title
  
  Journal of Biomolecular NMR
  
  Volume: 74 Issue: 10-11 Pages: 479-498
- DOI
  10.1007/s10858-020-00335-9
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-20H04722, KAKENHI-PROJECT-20H03378
[Journal Article] Spotlight on the Ballet of Proteins: The Structural Dynamic Properties of Proteins Illuminated by Solution NMR2020
- Author(s)
  Tokunaga Yuji、Viennet Thibault、Arthanari Haribabu、Takeuchi Koh
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 21 Issue: 5 Pages: 1829-1829
- DOI
  10.3390/ijms21051829
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K19415
[Journal Article] Structural Fingerprints of an Intact Monoclonal Antibody Acquired under Formulated Storage Conditions via 15N Direct Detection Nuclear Magnetic Resonance2020
- Author(s)
  Tokunaga Yuji、Takeuchi Koh、Okude Junya、Ori Kazutomo、Torizawa Takuya、Shimada Ichio
- Journal Title
  
  Journal of Medicinal Chemistry
  
  Volume: - Issue: 10 Pages: 5360-5366
- DOI
  10.1021/acs.jmedchem.0c00231
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07040, KAKENHI-PROJECT-18K19415, KAKENHI-PROJECT-18H02393, KAKENHI-PROJECT-17H06097
[Journal Article] Conformational equilibrium defines the variable induction of the multidrug-binding transcriptional repressor QacR2019
- Author(s)
  Koh Takeuchi, Misaki Imai, and Ichio Shimada
- Journal Title
  
  Proc. Natl. Acad. Sci. USA
  
  Volume: 116 Issue: 40 Pages: 19963-19972
- DOI
  10.1073/pnas.1906129116
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H02393, KAKENHI-PROJECT-17H06097
[Journal Article] Emerging solution NMR methods to illuminate the structural and dynamic properties of proteins2019
- Author(s)
  Haribabu Arthanari, KohTakeuchi, Abhinav Dubey, and Gerhard Wagner
- Journal Title
  
  Curr. Opin. Struct. Biol.
  
  Volume: 58 Pages: 294-304
- DOI
  10.1016/j.sbi.2019.06.005
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02393
[Journal Article] Aromatic 19F-13C TROSY: a background-free approach to probe biomolecular structure, function, and dynamics2019
- Author(s)
  Boeszoermenyi A, Chhabra S, Dubey A, Radeva D. L, Burdzhiev N. T, Chanev C. D, Petrov O. I, Gelev V. M, Zhang M, Anklin C, Kovacs H, Wagner G, Kuprov I, Takeuchi K, Arthanari H.
- Journal Title
  
  Nat. Methods
  
  Volume: 16 Issue: 4 Pages: 333-340
- DOI
  10.1038/s41592-019-0334-x
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02393
[Journal Article] 15N detection harnesses the slow relaxation property of nitrogen: Delivering enhanced resolution for intrinsically disordered proteins.2018
- Author(s)
  Chhabra S, Fischer P, Takeuchi K, Dubey A, Ziarek JJ, Boeszoermenyi A, Mathieu D, Bermel W, Davey NE, Wagner G, Arthanari H.
- Journal Title
  
  Proc. Natl. Acad. Sci. USA
  
  Volume: 115 Issue: 8 Pages: 1710-1719
- DOI
  10.1073/pnas.1717560115
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04340
[Journal Article] Application of C-terminal 7-azabicyclo[2.2.1]heptane to stabilize β?strand-like extended conformation of a neighboring α-amino acid2018
- Author(s)
  Luhan Zhai　 et al
- Journal Title
  
  J. Org. Chem.,
  
  Volume: 83 Issue: 21 Pages: 13063-13079
- DOI
  10.1021/acs.joc.8b01756
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H02552, KAKENHI-PROJECT-16K08157, KAKENHI-PROJECT-17H06097
[Journal Article] Mixed pyruvate labeling enables backbone resonance assignment of large proteins using a single experiment.2018
- Author(s)
  Robson S, Takeuchi K, Boeszoermenyi A, Coote P, Dubey A, Hyberts S, Wagner G, and Arthanari H.
- Journal Title
  
  Nat. Commun.
  
  Volume: 9 Issue: 1 Pages: 356-356
- DOI
  10.1038/s41467-017-02767-8
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04340
[Journal Article] Phosphoinositide binding by the PH domain in ceramide transfer protein (CERT) is inhibited by hyperphosphorylation of an adjacent serine-repeat motif2018
- Author(s)
  Sugiki Toshihiko、Egawa Daichi、Kumagai Keigo、Kojima Chojiro、Fujiwara Toshimichi、Takeuchi Koh、Shimada Ichio、Hanada Kentaro、Takahashi Hideo
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 293 Issue: 28 Pages: 11206-11217
- DOI
  10.1074/jbc.ra118.002465
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06649, KAKENHI-PUBLICLY-17H05836, KAKENHI-PUBLICLY-17H05873, KAKENHI-PLANNED-17H06417, KAKENHI-PUBLICLY-18H04626, KAKENHI-PROJECT-18H02393, KAKENHI-PROJECT-17H06097, KAKENHI-PROJECT-17H03641
[Journal Article] A small-molecule compound inhibits a collagen-specific molecular chaperone and could represent a potential remedy for fibrosis2017
- Author(s)
  S. Ito, K. Ogawa, K. Takeuchi, M. Takagi, M. Yoshida, T. Hirokawa, S. Hirayama, K. Shin-Ya, I. Shimada, T. Doi, N. Goshima, T. Natsume, K. Nagata
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 292 Issue: 49 Pages: 20076-20085
- DOI
  10.1074/jbc.m117.815936
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24227009, KAKENHI-PROJECT-17H06097, KAKENHI-PROJECT-16K20998
[Journal Article] Forbidden Coherence Transfer of 19F Nuclei to Quantitatively Measure the Dynamics of a CF3-Containing Ligand in Receptor-Bound States2017
- Author(s)
  Tokunaga Yuji、Takeuchi Koh、Shimada Ichio
- Journal Title
  
  Molecules
  
  Volume: 22 Issue: 9 Pages: 1492-1492
- DOI
  10.3390/molecules22091492
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K15083, KAKENHI-PROJECT-17H06097
[Journal Article] Revisiting the Field Dependence of TROSY Sensitivity2016
- Author(s)
  K. Takeuchi, H. Arthanari, and G. Wagner
- Journal Title
  
  Journal of Biomolecular NMR
  
  Volume: 66 Issue: 4 Pages: 221-225
- DOI
  10.1007/s10858-016-0075-4
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04340
[Journal Article] Nitrogen-detected TROSY yields comparable sensitivity to proton-detected TROSY for non-deuterated, large proteins under physiological salt conditions2016
- Author(s)
  K. Takeuchi, H. Arthanari, M. Imai, G. Wagner, I. Shimada
- Journal Title
  
  Journal of Biomolecular NMR
  
  Volume: 64 Issue: 2 Pages: 143-151
- DOI
  10.1007/s10858-016-0015-3
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04340
[Journal Article] Structural reverse genetics study of the PI5P4Kβ-nucleotide complexes reveals the presence of the GTP bioenergetic system in mammalian cells2016
- Author(s)
  K. Takeuchi, M. Senda, Y. H. Lo, S. Kofuji, Y. Ikeda, A. T. Sasaki, T. Senda
- Journal Title
  
  FEBS Journal
  
  Volume: 283 Issue: 19 Pages: 3556-3652
- DOI
  10.1111/febs.13739
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H04340
[Journal Article] Nitrogen detected TROSY at high field yields high resolution and sensitivity for protein NMR2015
- Author(s)
  K. Takeuchi, H. Arthanari, I. Shimada, and G. Wagner
- Journal Title
  
  J Biomol NMR
  
  Volume: 63 Pages: 323-331
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04340
[Journal Article] Suppression of problematic compound oligomerization by cosolubilization of nondetergent sulfobetaines2015
- Author(s)
  Y. Mizukoshi, K. Takeuchi, M. Arutaki, T. Takizawa, H. Hanzawa, H. Takahashi, and I. Shimada
- Journal Title
  
  ChemMedChem
  
  Volume: 10 Pages: 736-741
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04340
[Journal Article] Functional dynamics of cell surface membrane proteins.2014
- Author(s)
  Nishida N, Osawa M, Takeuchi K, Imai S, Stampoulis P, Kofuku Y, Ueda T, Shimada I
- Journal Title
  
  J Magn Reson
  
  Volume: 241 Pages: 86-96
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26713003
[Journal Article] NMR法により明らかとなるタンパク質複合体の機能的運動性2014
- Author(s)
  竹内　恒、嶋田　一夫
- Journal Title
  
  BULLETIN OF THE NUCLEAR MAGNETIC RESONANCE SOCIET Y OF JAPAN
  
  Volume: 5 Pages: 80-86
- NAID
  40020568081
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26713003
[Journal Article] Structure-based approach to improve a small-molecule inhibitor by the use of a competitive peptide ligand.2014
- Author(s)
  Ono K, Takeuchi K, Ueda H, Morita Y, Tanimura R, Shimada I, Takahashi H.
- Journal Title
  
  Angew Chem Int Ed Engl
  
  Volume: 53 Issue: 10 Pages: 2597-2597
- DOI
  10.1002/anie.201310749
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-21121001, KAKENHI-PLANNED-21121002, KAKENHI-PROJECT-23570146, KAKENHI-PROJECT-24370048, KAKENHI-PUBLICLY-25121743
[Journal Article] Dynamic multidrug recognition by multidrug transcriptional repressor LmrR2014
- Author(s)
  Takeuchi K, Tokunaga Y, Imai M, Takahashi H, Shimada I.
- Journal Title
  
  Sci Rep
  
  Volume: 4 Issue: 1 Pages: 6922-6922
- DOI
  10.1038/srep06922
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-ORGANIZER-21121001, KAKENHI-PROJECT-24370048, KAKENHI-PUBLICLY-26102735
[Journal Article] Functional dynamics of cell surface membrane proteins2014
- Author(s)
  Nishida N, Osawa M, Takeuchi K, Imai S, Stampoulis P, Kofuku Y, Ueda T, Shimada I
- Journal Title
  
  J Magn Reson
  
  Volume: 241 Pages: 86-96
- DOI
  10.1016/j.jmr.2013.11.007
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-ORGANIZER-21121001, KAKENHI-PLANNED-21121002, KAKENHI-PROJECT-24590048, KAKENHI-PROJECT-24770090, KAKENHI-PUBLICLY-25121707, KAKENHI-PUBLICLY-25121708, KAKENHI-PUBLICLY-25121743, KAKENHI-PROJECT-25460033, KAKENHI-PLANNED-26119005
[Journal Article] Degradation of activated K-Ras orthologue via K-Ras-specific lysine residues is required for cytokinesis.2014
- Author(s)
  Sumita K, Yoshino H, Sasaki M, Majd N, Kahoud ER, Takahashi H, Takeuchi K, Kuroda T, Lee S, Charest PG, Takeda K, Asara JM, Firtel RA, Anastasiou D, Sasaki AT.
- Journal Title
  
  J Biol Chem
  
  Volume: 289 Issue: 7 Pages: 3950-9
- DOI
  10.1074/jbc.m113.531178
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-25121743, KAKENHI-PROJECT-26670026
[Journal Article] Allosteric enhancement of MAP kinase p38α's activity and substrate selectivity by docking interactions2014
- Author(s)
  Tokunaga Y, Takeuchi K, Takahashi H, Shimada I
- Journal Title
  
  Nat Struct Mol Biol
  
  Volume: 21 Issue: 8 Pages: 704-711
- DOI
  10.1038/nsmb.2861
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-ORGANIZER-21121001, KAKENHI-PROJECT-24370048, KAKENHI-PUBLICLY-25121743, KAKENHI-PUBLICLY-26102735
[Journal Article] A homogeneous, high-throughput assay for phosphatidylinositol 5-phosphate 4-kinase with a novel, rapid substrate preparation2013
- Author(s)
  Davis MI, Sasaki AT, Shen M, Emerling BM, Thorne N, Michael S, Pragani R, Boxer M, Sumita K, Takeuchi K, Auld DS, Li Z, Cantley LC, Simenov A
- Journal Title
  
  PLoS One.
  
  Volume: 8 Issue: 1 Pages: e54127-e54127
- DOI
  10.1371/journal.pone.0054127
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790064, KAKENHI-PUBLICLY-23107735
[Journal Article] Perdeuteration and methyl-selective (1)H, (13)C-labeling by using a Kluyveromyces lactis expression system2013
- Author(s)
  Miyazawa-Onami M, Takeuchi K, Takano T, Sugiki T, Shimada I, Takahashi H.
- Journal Title
  
  J Biomol NMR
  
  Volume: 57 Issue: 3 Pages: 297-304
- DOI
  10.1007/s10858-013-9789-8
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-21121001, KAKENHI-PLANNED-21121002, KAKENHI-PROJECT-23570146, KAKENHI-PUBLICLY-24102524, KAKENHI-PROJECT-24370048, KAKENHI-PUBLICLY-25121743
[Journal Article] Rapid identification of ligand-binding sites by using an assignment-free NMR approach2013
- Author(s)
  Kodama Y, Takeuchi K, Shimba N, Ishikawa K, Suzuki E, Shimada I, Takahashi H.
- Journal Title
  
  J Med Chem
  
  Volume: 56 Issue: 22 Pages: 9342-9350
- DOI
  10.1021/jm4014357
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-21121001, KAKENHI-PLANNED-21121002, KAKENHI-PROJECT-23570146, KAKENHI-PUBLICLY-24102524, KAKENHI-PROJECT-24370048, KAKENHI-PUBLICLY-25121743
[Journal Article] Low g-nuclei detection experiments for bimolecular NMR2012
- Author(s)
  Takeuchi K, Gal M, Shimada I, Wagner G
- Journal Title
  
  Recent Developments in Biomolecular NMR
  
  Volume: (印刷中)
- Data Source
  KAKENHI-PUBLICLY-23107735
[Journal Article] Low g-nuclei detection experiments for bimolecular NMR2012
- Author(s)
  Takeuchi K, Gal M, Shimada I, Wagner G
- Journal Title
  
  Recent Developments in Biomolecular NMR
  
  Volume: 印刷中
- Data Source
  KAKENHI-PROJECT-23790064
[Journal Article] Structural basis for the Golgi association by the pleckstrin homology domain of the ceramide trafficking protein (CERT)2012
- Author(s)
  Sugiki T, Takeuchi K, Yamaji T, Takano T, Tokunaga Y, Kumagai K, Hanada K, Takahashi H, and Shimada I
- Journal Title
  
  J Biol Chem
  
  Volume: 287 Issue: 40 Pages: 33706-33718
- DOI
  10.1074/jbc.m112.367730
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22370054, KAKENHI-PROJECT-23770164, KAKENHI-PROJECT-23790064, KAKENHI-PROJECT-23790118, KAKENHI-PROJECT-24370048, KAKENHI-PROJECT-24890263, KAKENHI-PUBLICLY-23107735, KAKENHI-PUBLICLY-24102524
[Journal Article] Functional equilibrium of the KcsA structure revealed by NMR2012
- Author(s)
  Imai S, Osawa M, Mita K, Toyonaga S, Machiyama A, Ueda T, Takeuchi K, Oiki S, Shimada I.
- Journal Title
  
  J Biol Chem
  
  Volume: 287 Issue: 47 Pages: 39634-39641
- DOI
  10.1074/jbc.m112.401265
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21121002, KAKENHI-PROJECT-23370067, KAKENHI-PROJECT-23790064, KAKENHI-PROJECT-24590048, KAKENHI-PROJECT-24659096, KAKENHI-PROJECT-24659097, KAKENHI-PUBLICLY-23107708, KAKENHI-PUBLICLY-23107735, KAKENHI-ORGANIZER-21121001
[Journal Article] Functional dynamics of proteins revealed by solution NMR2012
- Author(s)
  Osawa M, Takeuchi K, Ueda T, Nishida N, Shimada I.
- Journal Title
  
  Curr Opin Struct Biol
  
  Volume: 22 Issue: 5 Pages: 660-669
- DOI
  10.1016/j.sbi.2012.08.007
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21121002, KAKENHI-PROJECT-23790064, KAKENHI-PROJECT-24590048, KAKENHI-PROJECT-24770090, KAKENHI-PUBLICLY-23107708, KAKENHI-PUBLICLY-23107735, KAKENHI-ORGANIZER-21121001
[Journal Article] Speeding up direct (15) N detection : hCaN 2D NMR experiment2011
- Author(s)
  Gal M, Edmonds KA, Milbradt AG, Takeuchi K, Wagner G
- Journal Title
  
  J Biomol NMR
  
  Volume: 51 Issue: 4 Pages: 497-504
- DOI
  10.1007/s10858-011-9580-7
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-23107735, KAKENHI-PROJECT-23790064
[Journal Article] Structure of the VP16 transactivator target in the Mediator2011
- Author(s)
  Milbradt AG, Kulkarni M, Yi T, Takeuchi K, Sun ZY, Luna RE, Selenko P, Naar AM, Wagner G
- Journal Title
  
  Nat Struct Mol Biol
  
  Volume: 18 Issue: 4 Pages: 410-415
- DOI
  10.1038/nsmb.1999
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-23107735, KAKENHI-PROJECT-23790064
[Journal Article] HNCA-TOCSY CANH experiments with alternate (13)C-(12)C labeling : a set of 3D experiment with unique supra-sequential information for mainchain resonance assignment.2011
- Author(s)
  Takeuchi K, Gal M, Takahashi H, Shimada I, Wagner G.
- Journal Title
  
  J Biomol NMR
  
  Volume: 49 Pages: 17-26
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22890246
[Journal Article] Ubiquitination of k-ras enhances activation and facilitates bin ding to select downstream effectors2011
- Author(s)
  Sasaki AT, Carracedo A, Locasale JW, Anastasiou D, Takeuchi K, Kahoud ER, Haviv S, Asara JM, Pandolfi PP, Cantley LC.
- Journal Title
  
  Sci Signal.
  
  Volume: 4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22890246
[Journal Article] Structure of the VP 16 transactivator target in the Mediator2011
- Author(s)
  Milbradt AG, Kulkarni M, Yi T, Takeuchi K, Sun ZY, Luna RE, Selenko P, Naar AM, Wagner G.
- Journal Title
  
  Nat Struct Mol Biol.
  
  Volume: 18(掲載確定)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22890246
[Journal Article] Protein-ligand docking guided by ligand pharmacophore-mapping experiment by NMR2011
- Author(s)
  Fukunishi Y, Mizukoshi Y, Takeuchi K, Shimada I, Takahashi H, Nakamura H.
- Journal Title
  
  J Mol Graph Model
  
  Volume: 31 Pages: 20-27
- DOI
  10.1016/j.jmgm.2011.08.002
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-23107735, KAKENHI-PROJECT-23790064
[Journal Article] Structural basis underlying the dual gate properties of KcsA2010
- Author(s)
  Imai S, Osawa M, Takeuchi K, Shimada I
- Journal Title
  
  Proc.Natl.Acad.Sci.USA.
  
  Volume: 107 Pages: 6216-6221
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22890246
[Journal Article] Distinctive CD3 Heterodimeric Ectodomain Topologies Maximize Antigen-triggered Activation of αss T Cell Receptors2010
- Author(s)
  Kim ST, Touma M, Takeuchi K, Sun ZY, Dave VP, Kappes DJ, Wagner G, Reinherz EL
- Journal Title
  
  J Immunol
  
  Volume: 185 Pages: 2951-2959
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22890246
[Journal Article] CACA-TOCSY with alternate ^<13>C-^<12>C labeling : a ^<13>C^α direct detection experiment for mainchain resonance assignment, dihedral angle information, and amino acid type identification2010
- Author(s)
  Takeuchi K, Frueh D, Sun ZY, Hiller S, Wagner G
- Journal Title
  
  J Biomol NMR
  
  Volume: 47 Pages: 55-63
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22890246
[Journal Article] Nitrogen-detected CAN and CON experiments as alternative experiments for main chain NMR resonance assignments2010
- Author(s)
  Takeuchi K, Heffron G, Sun ZY, Frueh DP, Wagner G
- Journal Title
  
  J Biomol NMR
  
  Volume: 47 Pages: 271-282
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22890246
[Journal Article] NMR analyses of the G{beta}{gamma} binding and conformational rearrangements of the cytoplasmic pore of G protein-activated inwardly rectifying potassium channel 1 (GIRK1).2010
- Author(s)
  Yokogawa M, Osawa M, Takeuchi K, Mase Y, Shimada I
- Journal Title
  
  J Biol Chem
  
  Volume: 286 Pages: 2215-23
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22890246
[Journal Article] Autoinhibitory Interaction in the Multidomain Adaptor Protein Nck : Possible Roles in Improving Specificity and Functional Diversity2010
- Author(s)
  Takeuchi K, Sun ZY, Park S, Wagner G
- Journal Title
  
  Biochemistry
  
  Volume: 49 Pages: 5634-5641
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22890246
[Presentation] Affinity-driven H+-coupled transport of a MATE transporter2023
- Author(s)
  Koh Takeuchi
- Organizer
  2023 Asia-Pacific Nuclear Magnetic Resonance (APNMR) Symposium
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K18374
[Presentation] NMR analysis of target recognition mechanism of anti-VEGF RNA aptamer2023
- Author(s)
  Koh Takeuchi, Ichio Shimada
- Organizer
  第62回NMR討論会
- Data Source
  KAKENHI-PROJECT-22K18374
[Presentation] Affinity-directed substrate/H+ antiport of a MATE transporter2023
- Author(s)
  Koh Takeuchi
- Organizer
  International Society of Magnetic Resonance 2023
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K18374
[Presentation] NMR-based strategy to improve protein druggability2023
- Author(s)
  Koh Takeuchi
- Organizer
  Medicinal Chemistry Section of the Israel Chemical Society (MCS-ICS)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K18374
[Presentation] 大腸菌由来tRNA硫黄修飾関連タンパク質TusEによる硫黄運搬の構造機構の溶液NMR解析2023
- Author(s)
  徳永裕二、鴫直樹、竹内恒
- Organizer
  第96回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-21H02436
[Presentation] Affinity-driven H+-coupled transport of a MATE transporter2022
- Author(s)
  Koh Takeuchi
- Organizer
  The 61st Annual Meeting of the NMR Society of Japan
- Data Source
  KAKENHI-PROJECT-20H03378
[Presentation] How does a molecule drive life?2022
- Author(s)
  竹内恒
- Organizer
  第22回日本蛋白質科学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-20H03378
[Presentation] Utilization of NMR dynamics information to improve protein druggability2022
- Author(s)
  Koh Takeuchi
- Organizer
  The 7th International Symposium on Drug Discovery and Design by NMR
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03378
[Presentation] 大腸菌由来tRNA硫黄修飾関連タンパク質TusEによる硫黄運搬の構造機構の溶液NMR解析2022
- Author(s)
  徳永裕二、鴫直樹、嶋田一夫、竹内恒
- Organizer
  第95回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-21H02436
[Presentation] Conformational plasticity defines cell permeabilization activity of cyclic Ras-inhibitor peptides2022
- Author(s)
  Koh Takeuchi
- Organizer
  ICMRBS 2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03378
[Presentation] Development of inhibitors for the GTP energy system2022
- Author(s)
  Koh Takeuchi
- Organizer
  分子生物学会年会2022
- Invited
- Data Source
  KAKENHI-PROJECT-20H03378
[Presentation] Ras阻害環状ペプチドの構造的柔軟性が決める細胞内移行性2021
- Author(s)
  竹内　恒
- Organizer
  59回生物物理学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-20K21494
[Presentation] 動的生命現象のNMRを用いた理解と創薬への応用2021
- Author(s)
  竹内　恒
- Organizer
  日本薬学会東海支部
- Invited
- Data Source
  KAKENHI-PROJECT-20H03378
[Presentation] 動的生命現象のNMRを用いた理解と創薬への応用2021
- Author(s)
  竹内　恒
- Organizer
  日本薬学会東海支部
- Invited
- Data Source
  KAKENHI-PUBLICLY-20H04722
[Presentation] NMRを用いた動的生命現象の理解と創薬への応用2021
- Author(s)
  竹内　恒
- Organizer
  第65回日本薬学会関東支部大会
- Invited
- Data Source
  KAKENHI-PROJECT-20K21494
[Presentation] Ras阻害環状ペプチドの構造的柔軟性が決める細胞内移行性2021
- Author(s)
  竹内恒
- Organizer
  第59回生物物理学会
- Invited
- Data Source
  KAKENHI-PROJECT-17H06097
[Presentation] NMRを用いた動的生命現象の理解と創薬への応用2021
- Author(s)
  竹内　恒
- Organizer
  第65回日本薬学会関東支部大会
- Invited
- Data Source
  KAKENHI-PUBLICLY-20H04722
[Presentation] 神経栄養因子NGF高親和性受容体TrkAドメイン5と新規結合ペプチドの相互作用解析2021
- Author(s)
  鈴木里佳、登坂綺水、浴本亨、髙橋真帆、山根努、坂倉正義、水越弓子、竹内恒、嶋田一夫、池口満徳、高橋栄夫
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-18H02393
[Presentation] Targeting cryptic sites: NMR-based strategy to improve protein druggability by controlling conformational equilibrium2021
- Author(s)
  Koh Takeuchi
- Organizer
  ISMAR-APNMR-NMRSJ2021
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06097
[Presentation] 動的生命現象のNMRを用いた理解と創薬への応用2021
- Author(s)
  竹内　恒
- Organizer
  日本薬学会東海支部
- Invited
- Data Source
  KAKENHI-PROJECT-20K21494
[Presentation] 溶液 NMR による多様な創薬モダリティに対する動的構造創薬2021
- Author(s)
  竹内恒
- Organizer
  第21回日本蛋白質科学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-17H06097
[Presentation] NMRを用いた動的生命現象の理解と創薬への応用2021
- Author(s)
  竹内恒
- Organizer
  第65回日本薬学会関東支部大会
- Invited
- Data Source
  KAKENHI-PROJECT-18H02393
[Presentation] Ras阻害環状ペプチドの構造的柔軟性が決める細胞内移行性2021
- Author(s)
  竹内　恒
- Organizer
  59回生物物理学会年会
- Invited
- Data Source
  KAKENHI-PUBLICLY-20H04722
[Presentation] NMRを用いた動的生命現象の理解と創薬への応用2021
- Author(s)
  竹内　恒
- Organizer
  第65回日本薬学会関東支部大会
- Invited
- Data Source
  KAKENHI-PROJECT-20H03378
[Presentation] NMRを用いた動的構造解析への取り組みと創薬への展開2020
- Author(s)
  竹内恒
- Organizer
  第59回 NMR 討論会
- Invited
- Data Source
  KAKENHI-PROJECT-17H06097
[Presentation] 細胞透過性を決めるRas阻害環状ペプチドの構造的柔軟性2020
- Author(s)
  竹内恒，今井美咲, 徳永裕二,藤崎美和, 鴨志田一, 滝沢剛, 半沢宏之,嶋田一夫
- Organizer
  第59回 NMR 討論会
- Data Source
  KAKENHI-PROJECT-20K21494
[Presentation] 溶液NMRを用いた動的構造創薬2020
- Author(s)
  竹内恒
- Organizer
  第93回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-18H02393
[Presentation] NMRを用いた動的構造解析による多剤耐性機構の理解2020
- Author(s)
  竹内恒
- Organizer
  第5回トランスポーター研究会関東部会（JTRAK2020）
- Invited
- Data Source
  KAKENHI-PROJECT-17H06097
[Presentation] 溶液NMRを用いた動的構造創薬2020
- Author(s)
  竹内　恒
- Organizer
  第93回日本生化学会大会
- Invited
- Data Source
  KAKENHI-PUBLICLY-20H04722
[Presentation] 溶液NMRを用いた動的構造創薬2020
- Author(s)
  竹内恒
- Organizer
  2020年度日本分光学会ＮＭＲ分光部会
- Data Source
  KAKENHI-PROJECT-18H02393
[Presentation] 溶液NMRを用いた動的構造創薬2020
- Author(s)
  竹内　恒
- Organizer
  第93回日本生化学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-20H03378
[Presentation] Conformational equilibrium defines variable transcriptional repression of a multidrug binding transcriptional repressor, QacR2019
- Author(s)
  Koh Takeuchi, Imai Misaki, and Ichio Shimada
- Organizer
  The 8th Asia-Pacific NMR symposium
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06097
[Presentation] バイオ計測とバイオITの融合による創薬プラットフォーム技術の構築とその展開2019
- Author(s)
  竹内恒
- Organizer
  平成30年度産技連　関東甲信越静地域部会　食品・バイオ分科会
- Invited
- Data Source
  KAKENHI-PROJECT-17H06097
[Presentation] Conformational equilibrium defines transcriptional repression of multidrug binding transcriptional repressors2019
- Author(s)
  竹内恒,水越弓子,德永裕二,滝沢剛,半沢宏之、嶋田一夫
- Organizer
  日本分子生物学会年会 2019
- Invited
- Data Source
  KAKENHI-PROJECT-17H06097
[Presentation] Conformational equilibrium defines variable transcriptional repression of a multidrug binding transcriptional repressor, QacR2019
- Author(s)
  Koh Takeuchi
- Organizer
  8th Asia-Pacific NMR Symposium 2019
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02393
[Presentation] Targeting the cryptic sites: NMR-based strategy to improve the draggability of proteins by controlling the conformational equilibrium2019
- Author(s)
  Koh Takeuchi, Yumiko Mizukoshi, Yuji Tokunaga, Hitomi Matsuo, Takeshi Takizawa, Hiroyuki Hanzawa, and Ichio Shimada.
- Organizer
  第57 回日本生物物理学会年会
- Data Source
  KAKENHI-PROJECT-17H06097
[Presentation] Targeting the cryptic sites: NMR-based strategy to improve the draggability of proteins by controlling the conformational equilibrium.2019
- Author(s)
  Ko Takeuchi
- Organizer
  第57回生物物理学会年会
- Data Source
  KAKENHI-PROJECT-18H02393
[Presentation] 構造平衡制御によるタンパク質のドラッガビリティの改善2019
- Author(s)
  竹内恒,水越弓子,德永裕二,滝沢剛,半沢宏之、嶋田一夫
- Organizer
  第58回NMR討論会
- Data Source
  KAKENHI-PROJECT-17H06097
[Presentation] 多剤耐性転写制御の動的構造機能解析2018
- Author(s)
  竹内恒嶋田一夫
- Organizer
  第18回蛋白質科学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-17H06097
[Presentation] 15N 直接検出NMR法による高分子量バイオ医薬の非侵襲的観測2018
- Author(s)
  徳永裕二，竹内恒，鳥澤拓也，奥出順也，嶋田一夫
- Organizer
  第57回NMR討論会
- Data Source
  KAKENHI-PROJECT-18K19415
[Presentation] 構造平衡により規定される多剤結合転写因子QacRの可変的転写制御2018
- Author(s)
  竹内恒嶋田一夫
- Organizer
  第56回生物物理学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-17H06097
[Presentation] Mechanism of multidrug resistance transcriptional regulation revealed by dynamic analysis using NMR2018
- Author(s)
  Koh Takeuchi
- Organizer
  The Protein Society 32nd Annual symposium
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06097
[Presentation] Dynamic structure-guided optimization of ligand2018
- Author(s)
  Koh Takeuchi
- Organizer
  The Israeli 2018 Magnetic Resonance Meeting
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06097
[Presentation] Dynamic structure-guided optimization of ligand using FCT method2018
- Author(s)
  Koh Takeuchi, Yuji Tokunaga, Yumiko Mizukoshi, Ichio Shimada
- Organizer
  International Conference on Magnetic Resonance in Biological Systems 2018
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06097
[Presentation] 禁制コヒーレント遷移を用いたリガンドの動的構造最適化2018
- Author(s)
  竹内恒水越弓子德永裕二滝沢剛半沢宏之嶋田一夫
- Organizer
  第57回NMR討論会（誌上開催）
- Invited
- Data Source
  KAKENHI-PROJECT-17H06097
[Presentation] Mechanism of multidrug resistance transcriptional regulation revealed by quantitative dynamic analysis using site-specific isotope labeling2017
- Author(s)
  竹内　恒、嶋田　一夫
- Organizer
  第56回日本核磁気共鳴学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-17H06097
[Presentation] 動的構造解析による多剤耐性転写制御因子の非特異的かつ高親和性な結合メカニズムの解明2017
- Author(s)
  竹内　恒、今井　美咲、德永　裕二、嶋田　一夫
- Organizer
  第55回生物物理学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-17H06097
[Presentation] セラミド輸送蛋白質CERTのPHドメイン－Golgi体間結合がCERTのリン酸化によって抑制される構造基盤：溶液NMR法による解析2016
- Author(s)
  杉木俊彦、熊谷圭吾、江川大地、児嶋長次郎、藤原敏道、竹内恒、嶋田一夫、花田賢太郎、高橋栄夫
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Data Source
  KAKENHI-PROJECT-15H04340
[Presentation] Structural Basis for the Optimum Signal Transduction via MAPK p38a under the Stress-associated ATP-depleted, Low pH Condition Elucidated by Solution NMR2016
- Author(s)
  Y. Tokunaga, K. Takeuchi, H. Takahashi and I. Shimada
- Organizer
  XXVIIth International Conference on Magnetic Resonance in Biological Systems
- Place of Presentation
  京都国際会館（京都府京都市）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04340
[Presentation] Dynamic Multidrug Recognition and Transcriptional Regulation by a Multidrug Transcriptional Repressor LmrR2016
- Author(s)
  K. Takeuchi, Y. Tokunaga, M. Imai, H. Takahashi, and I. Shimada
- Organizer
  XXVIIth International Conference on Magnetic Resonance in Biological Systems
- Place of Presentation
  京都国際会館（京都府京都市）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04340
[Presentation] 高分解能、高感度な15N窒素核観測を可能にする高磁場TROSY測定2015
- Author(s)
  竹内恒
- Organizer
  第54回NMR討論会
- Place of Presentation
  千葉・千葉工業大学津田沼キャンパス
- Year and Date
  2015-11-06
- Data Source
  KAKENHI-PROJECT-15H04340
[Presentation] 多剤耐性転写制御因子の運動性と薬剤認識機構のNMR解析2013
- Author(s)
  竹内　恒、高橋　栄夫、嶋田　一夫
- Organizer
  日本核磁気共鳴学会
- Place of Presentation
  石川県立音楽堂（金沢市）
- Data Source
  KAKENHI-PUBLICLY-25121743
[Presentation] NMR Analysis of Functional Fluctuation in Large Molecular Weight Protein2012
- Author(s)
  竹内恒、徳永裕二、高橋栄夫、嶋田一夫
- Organizer
  新学術領域「揺らぎが機能を決める生命分子の科学」国際シンポジウム
- Place of Presentation
  奈良県・東大寺(招待講演)
- Data Source
  KAKENHI-PUBLICLY-23107735
[Presentation] NMR Analysis of Functional Fluctuation in Large Molecular Weight Protein2012
- Author(s)
  竹内　恒、徳永　裕二、高橋　栄夫、嶋田　一夫
- Organizer
  新学術領域「揺らぎが機能を決める生命分子の科学」国際シンポジウム(招待講演)
- Place of Presentation
  奈良県・東大寺
- Data Source
  KAKENHI-PROJECT-23790064
[Presentation] 酵母K.Lactis発現系を用いた高分子量蛋白質の重水素化およびメチル選択標識2012
- Author(s)
  宮沢-大浪　真由美,竹内　恒, 杉木　俊彦, 高野　等覚, 嶋田　一夫, 高橋　栄夫
- Organizer
  第51回NMR討論会
- Place of Presentation
  愛知県名古屋市・ウインクあいち
- Data Source
  KAKENHI-PROJECT-23790064
[Presentation] NMR approach to study and interfere with blood coagulation responses2012
- Author(s)
  竹内　恒
- Organizer
  難治性疾患統合創薬プロジェクト講演会(招待講演)
- Place of Presentation
  滋賀県・立命館大学
- Data Source
  KAKENHI-PROJECT-23790064
[Presentation] 多剤耐性転写制御因子の揺らぎによる薬剤認識機構2012
- Author(s)
  竹内　恒、嶋田　一夫
- Organizer
  新学術領域「揺らぎと生体機構」「水和とATP」合同公開シンポジウム「ゆらぎと水－生命のエネルギーと機能の分子機構を探る」
- Place of Presentation
  大阪府大阪市・大阪ガーデンパレス
- Data Source
  KAKENHI-PUBLICLY-23107735
[Presentation] 多剤耐性転写制御因子の揺らぎによる薬剤認識機構2012
- Author(s)
  竹内　恒、嶋田　一夫
- Organizer
  新学術領域「揺らぎと生体機構」「水和とATP」合同公開シンポジウム「ゆらぎと水－生命のエネルギーと機能の分子機構を探る」
- Place of Presentation
  大阪府大阪市・大阪ガーデンパレス
- Data Source
  KAKENHI-PROJECT-23790064
[Presentation] NMR approach to study and interfere with blood coagulation responses2012
- Author(s)
  竹内恒
- Organizer
  難治性疾患統合創薬プロジェクト講演会
- Place of Presentation
  滋賀県・立命館大学(招待講演)
- Year and Date
  2012-01-30
- Data Source
  KAKENHI-PUBLICLY-23107735
[Presentation] 多剤耐性転写制御因子の揺らぎによる薬剤認識機構2012
- Author(s)
  竹内恒、嶋田一夫
- Organizer
  新学術領域「揺らぎと生体機構」「水和と ATP」合同公開シンポジウム「ゆらぎと水-生命のエネルギーと機能の分子機構を探る」
- Place of Presentation
  大阪ガーデンパレス(大阪府)
- Year and Date
  2012-09-14
- Data Source
  KAKENHI-PROJECT-23790064
[Presentation] 酵母K.Lactis発現系を用いた高分子量蛋白質の重水素化およびメチル選択標識2012
- Author(s)
  宮沢-大浪　真由美,竹内　恒, 杉木　俊彦, 高野　等覚, 嶋田　一夫, 高橋　栄夫
- Organizer
  第51回NMR討論会
- Place of Presentation
  愛知県名古屋市・ウインクあいち
- Data Source
  KAKENHI-PUBLICLY-23107735
[Presentation] NMR approach to study and interfere with blood coagulation responses2012
- Author(s)
  竹内恒
- Organizer
  難治性疾患統合創薬プロジェクト講演会
- Place of Presentation
  立命館大学(滋賀県)
- Year and Date
  2012-01-30
- Data Source
  KAKENHI-PROJECT-23790064
[Presentation] 酵母K.lactis発現系を用いた高分子量蛋白質の重水素化およびメチル選択標識2012
- Author(s)
  竹内怛
- Organizer
  第51回NMR討論会
- Place of Presentation
  ウインクあいち(名古屋)
- Data Source
  KAKENHI-PROJECT-24370048
[Presentation] HNCA-TOCSY-CANH experiments with alternate 13C-12C labeling: a set of 3D experiment with unique supra-sequential information for mainchain resonance assignment2011
- Author(s)
  Koh Takeuchi, Maayan Gal, Hideo Takahashi, Gerhard Wagner, and Ichio Shimada
- Organizer
  ISNMR2011
- Place of Presentation
  大桟橋ホール(神奈川県)
- Data Source
  KAKENHI-PROJECT-23790064
[Presentation] T細胞活性化のしくみTCRはナノマシーンか？-NMRおよび光ピンセット法による解析-2011
- Author(s)
  竹内　恒、嶋田　一夫
- Organizer
  第６回構造生物学に関する先端技術講演会(招待講演)
- Place of Presentation
  福岡県・九州大学
- Data Source
  KAKENHI-PROJECT-23790064
[Presentation] T 細胞レセプターはダイナミックかつ協同的な 4 次元構造変化により活性化する-NMR および光ピンセット法による解析-2011
- Author(s)
  竹内恒、嶋田一夫
- Organizer
  第49回日本生物物理学会年会
- Place of Presentation
  姫路工大(兵庫県)
- Data Source
  KAKENHI-PROJECT-23790064
[Presentation] T細胞レセプターはダイナミックかつ協同的な4次元構造変化により活性化する-NMRおよび光ピンセット法による解析-2011
- Author(s)
  竹内恒、嶋田一夫
- Organizer
  第49回日本生物物理学会年会
- Place of Presentation
  兵庫県・姫路工大(招待講演)
- Year and Date
  2011-09-16
- Data Source
  KAKENHI-PUBLICLY-23107735
[Presentation] T細胞レセプターはダイナミックかつ協同的な4次元構造変化により活性化する－NMRおよび光ピンセット法による解析－2011
- Author(s)
  竹内　恒、嶋田　一夫
- Organizer
  第49回日本生物物理学会年会(招待講演)
- Place of Presentation
  兵庫県・姫路工大
- Data Source
  KAKENHI-PROJECT-23790064
[Presentation] HNCA-TOCSY-CANH experiments with alternate 13C-12C labeling: a set of 3D experiment with unique supra-sequential information for mainchain resonance assignment2011
- Author(s)
  Koh Takeuchi1, Maayan Gal, Hideo Takahashi, Gerhard Wagner, and Ichio Shimada
- Organizer
  ISNMR2011
- Place of Presentation
  神奈川県・大桟橋ホール
- Data Source
  KAKENHI-PROJECT-23790064
[Presentation] 高分子量蛋白質のNMR解析に適した13C標識法および測定法の開発2011
- Author(s)
  竹内恒
- Organizer
  よこはまNMR構造生物学研究会
- Place of Presentation
  理化学研究所横浜研究所交流ホール(神奈川県)
- Year and Date
  2011-03-02
- Data Source
  KAKENHI-PROJECT-22890246
[Presentation] HNCA-TOCSY-CANH experiments with alternate 13C-12C labeling : a set of 3D experiment with unique supra-sequential information for mainchain resonance assignment2011
- Author(s)
  Koh Takeuchi, Maayan Gal, Hideo Takahashi, Gerhard Wagner, Ichio Shimada
- Organizer
  ISNMR2011
- Place of Presentation
  神奈川県・大桟橋ホール
- Year and Date
  2011-11-16
- Data Source
  KAKENHI-PUBLICLY-23107735
[Presentation] T細胞活性化のしくみTCRはナノマシーンか?-NMRおよび光ピンセット法による解析-2011
- Author(s)
  竹内恒、嶋田一夫
- Organizer
  第6回構造生物学に関する先端技術講演会
- Place of Presentation
  福岡県・九州大学(招待講演)
- Year and Date
  2011-09-02
- Data Source
  KAKENHI-PUBLICLY-23107735
[Presentation] 細胞レセプターはダイナミックかつ協同的な4次元構造変化により活性化する2010
- Author(s)
  竹内恒
- Organizer
  BMB2010
- Place of Presentation
  神戸ポートアイランド(兵庫県)
- Year and Date
  2010-12-08
- Data Source
  KAKENHI-PROJECT-22890246
[Presentation] 高分子量蛋白質のNMR解析に適した安定同位体標識法および測定法の開発2010
- Author(s)
  竹内恒
- Organizer
  日本分光学会年会
- Place of Presentation
  京都大学(京都府)
- Year and Date
  2010-11-20
- Data Source
  KAKENHI-PROJECT-22890246
[Presentation] 高分子量蛋白質の構造解析に適した安定同位体ラベル法および測定法の開発2010
- Author(s)
  竹内恒
- Organizer
  NMR討論会
- Place of Presentation
  タワーホール船堀(東京都)
- Year and Date
  2010-11-17
- Data Source
  KAKENHI-PROJECT-22890246
[Presentation] Dynamic multidrug recognition by multidrug transcriptional repressor LmrR from Lactococcus lactis
- Author(s)
  Koh Takeuchi and Ichio Shimada.
- Organizer
  ICMRBS 2014
- Place of Presentation
  Hyatt Regency Dallas、Dallas, USA
- Year and Date
  2014-08-24 – 2014-08-29
- Data Source
  KAKENHI-PROJECT-26713003
[Presentation] 多剤耐性転写制御因子LmrRの運動性と多剤薬剤認識機構のNMR解析
- Author(s)
  竹内　恒、嶋田　一夫
- Organizer
  第14回日本蛋白質科学会年会
- Place of Presentation
  ワークピア横浜、横浜
- Year and Date
  2014-06-25 – 2014-06-27
- Data Source
  KAKENHI-PROJECT-26713003
[Presentation] 高難度タンパク質のNMR解析に向けた酵母発現系の活用
- Author(s)
  高橋栄夫、大浪真由美、杉木俊彦、坂倉正義、竹内恒、嶋田一夫
- Organizer
  第53回NMR討論会
- Place of Presentation
  大阪
- Year and Date
  2014-11-04 – 2014-11-06
- Data Source
  KAKENHI-PROJECT-24370048
[]

1. TAKAHASHI Hideo (60265717)

# of Collaborated Projects: 3 results

# of Collaborated Products: 6 results
2. 徳永裕二 (80713354)

# of Collaborated Projects: 3 results

# of Collaborated Products: 7 results
3. SAKAKURA Masayoshi (20334336)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
4. Shimada Ichio (70196476)

# of Collaborated Projects: 1 results

# of Collaborated Products: 19 results
5. Omori Kazuhiro (20549860)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. Shigi Naoki (20392623)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
7. 上田卓見 (20451859)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
8. 西田紀貴 (50456183)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. 中山真彰 (10579105)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 高柴正悟 (50226768)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 萬代大樹 (60534427)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 堀谷正樹 (80532134)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. KUMAGAI Keigo

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
14. YAMAJI Toshiyuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. ITO Shinya

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 花田賢太郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 今清水正彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 永田和宏

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 渡邉瑞貴

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. 周東智

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 藤原広一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. 佐々木敦朗

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. 須佐紘一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. 森次圭

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
25. 川口寧

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
26. 大澤匡範

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
27. 神田大輔

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Takeuchi Kou 竹内 恒

TAKEUCHI Koh 竹内 恒

Research Projects

Research Products

Co-Researchers

in cell structure-guided drug development by NMRPrincipal Investigator

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Molecular basis for biosynthetic and degradation systems for tRNA sulfur-modified bases

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Development of basic strategy to structurally evaluate the membrane permeation activity of middle-size moleculesPrincipal Investigator

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分子夾雑環境下におけるタンパク質と薬物の動的相互作用解析Principal Investigator

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Structure and dynamics based drug development to obtain highly active compoundsPrincipal Investigator

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Identification and Functional Analysis of the Target Molecule of Terrein, a Small Molecule Compound for Application in the Super-Aging Society

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NMR method to obtain structural fingerprints of an intact monoclonal antibody acquired under formulated storage conditionsPrincipal Investigator

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Analysis of functional dynamics of membrane proteins in different membrane environments

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In situ functional analyses of membrane proteins by NMR

Principal Investigator

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NMR approach for the functional structural analyses of human membrane proteins

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多剤耐性転写制御因子の動的薬剤認識と機能発現のＮＭＲ解析Principal Investigator

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X線結晶構造解析・核磁気共鳴法の融合によるキナーゼ複合体の動的立体構造解析Principal Investigator

Principal Investigator

Project Period (FY)

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Research Institution

Fundamental research for NMR structural analysis of human membrane proteins

Principal Investigator

Project Period (FY)

Takeuchi Kou 竹内恒

TAKEUCHI Koh 竹内恒